DOCSLIB.ORG

Human GPCR Expression List

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Human GPCR Expression List Human GPCR Expression List (n= 85) 2014/8/1 - No Official Symbol Official Full Name Aliases Gene ID A 1 ACRBP acrosin binding protein CT23, OY-TES-1, SP32 84519 2 ADORA2A adenosine A2a receptor A2aR, ADORA2, RDC8 135 3 ADORA2B adenosine A2b receptor ADORA2 136 4 AGTR1 angiotensin II receptor, type 1 AG2SB, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R, AGTR1 185 5 AGTR2 angiotensin II receptor, type 2 AT2, ATGR2, MRX88 186 C 6 C3AR1 complement component 3a receptor 1 AZ3B, C3AR, HNFAG09 719 7 C5AR2 complement component 5a receptor 2 C5L2, GPF77, GPR77 27202 8 C5R1 complement component 5a receptor 1 C5A, C5AR, C5R1, CD88 728 9 CALCR calcitonin receptor CRT, CT-R, CTR, CTR1 799 10 CCKAR cholecystokinin A receptor CCK-A, CCK1-R, CCK1R, CCKRA 886 11 CCR1 chemokine (C-C motif) receptor 1 CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1 1230 CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, 12 CCR5 chemokine (C-C motif) receptor 5 1234 IDDM22 13 CCR9 chemokine (C-C motif) receptor 9 CC-CKR-9, CDw199, GPR-9-6, GPR28 10803 14 CD97 CD97 molecule TM7LN1 976 15 CHRM1 cholinergic receptor, muscarinic 1 HM1, M1, M1R 1128 16 CX3CR1 chemokine (C-X3-C motif) receptor 1 CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28 1524 C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, 17 CXCR1 chemokine (C-X-C motif) receptor 1 3577 IL8RA, IL8RBA 18 CXCR2 chemokine (C-X-C motif) receptor 2 CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB 3579 19 CXCR6 chemokine (C-X-C motif) receptor 6 BONZO, CD186, STRL33, TYMSTR 10663 20 CYSLTR1 cysteinyl leukotriene receptor 1 CYSLT1, CYSLT1R, CYSLTR, HMTMF81 10800 D 21 DRD1 dopamine receptor D1 DADRA, DRD1 1812 E 22 EDNRA endothelin receptor type A ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR 1909 RP11-318G21.1, ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, 23 EDNRB endothelin receptor type B 1910 HSCR2, WS4A coagulation factor II (thrombin) F 24 F2RL2 PAR-3, PAR3 2151 receptor-like 2 25 FFAR3 free fatty acid receptor 3 FFA3R, GPR41 2865 26 FGFR1OP FGFR1 oncogene partner FOP 11116 27 FPR1 formyl peptide receptor 1 FMLP, FPR 2357 ALXR, FMLP-R-II, FMLPXA, FPRH1, FPRH2, FPRL1, HM63, LXA4R, 28 FPR2 formyl peptide receptor 2 2358 FPR2 1 PRO3GPCR-201408（Ⅰ） Human GPCR Expression List (n= 85) 2014/8/1 - No Official Symbol Official Full Name Aliases Gene ID 29 FZD4 frizzled class receptor 4 CD344, EVR1, FEVRS, Fz-4, Fz4, FzE4, GPCR, hFz4, FZD4 8322 30 FZD6 frizzled class receptor 6 FZ-6, FZ6, HFZ6, NDNC10 8323 31 FZD7 frizzled class receptor 7 FzE3 8324 G 32 GLP2R glucagon-like peptide 2 receptor 9340 33 GPBAR1 G protein-coupled bile acid receptor 1 BG37, GPCR19, GPR131, M-BAR, TGR5 151306 CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, 34 GPER1 G protein-coupled estrogen receptor 1 2852 LERGU2, LyGPR, mER 35 GPR12 G protein-coupled receptor 12 GPCR12, GPCR21, PPP1R84 2835 36 GPR137B G protein-coupled receptor 137B RP5-985L19.1, TM7SF1 7107 37 GPR146 G protein-coupled receptor 146 PGR8 115330 38 GPR15 G protein-coupled receptor 15 BOB 2838 39 GPR155 G protein-coupled receptor 155 DEP.7, DEPDC3, PGR22 151556 40 GPR17 G protein-coupled receptor 17 2840 41 GPR171 G protein-coupled receptor 171 H963 29909 42 GPR173 G protein-coupled receptor 173 RP1-290F12.1, SREB3 54328 43 GPR18 G protein-coupled receptor 18 RP11-461N23.8 2841 44 GPR182 G protein-coupled receptor 182 7TMR, ADMR, AM-R, AMR, G10D, gamrh, hrhAMR 11318 45 GPR3 G protein-coupled receptor 3 ACCA 2827 46 GPR39 G protein-coupled receptor 39 2863 47 GPR55 G protein-coupled receptor 155 LPIR1 9290 48 GPR63 G protein-coupled receptor 63 PSP24(beta), PSP24B 81491 49 GPR82 G protein-coupled receptor 82 RP11-204C16.5 27197 50 GPR84 G protein-coupled receptor 84 EX33, GPCR4 53831 51 GPR85 G protein-coupled receptor 85 SREB, SREB2 54329 52 GRPR gastrin-releasing peptide receptor BB2 2925 H 53 HCAR1 hydroxycarboxylic acid receptor 1 FKSG80, GPR104, GPR81, HCA1, LACR1, TA-GPCR, TAGPCR 27198 54 HCAR2 hydroxycarboxylic acid receptor 2 GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g 338442 55 HCAR3 hydroxycarboxylic acid receptor 3 GPR109B, HCA3, HM74, PUMAG, Puma-g 8843 56 HCRTR2 hypocretin (orexin) receptor 2 OX2R 3062 5-hydroxytryptamine (serotonin) 57 HTR1D 5-HT1D, HT1DAA, HTRL, RDC4, HTR1D 3352 receptor 1D, G protein-coupled 5-hydroxytryptamine (serotonin) 58 HTR2A RP11-147L20.2, 5-HT2A, HTR2 3356 receptor 2A, G protein-coupled 2 PRO3GPCR-201408（Ⅰ） Human GPCR Expression List (n= 85) 2014/8/1 - No Official Symbol Official Full Name Aliases Gene ID 5-hydroxytryptamine (serotonin) 59 HTR2B 5-HT(2B), 5-HT2B 3357 receptor 2B leucine-rich repeat containing G L 60 LGR6 RP11-572A16.3, GPCR, VTS20631 59352 protein-coupled receptor 6 61 LPAR4 lysophosphatidic acid receptor 4 GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9 2846 M 62 MC4R melanocortin 4 receptor 4160 melanin-concentrating hormone 63 MCHR1 CTA-229A8.4, GPR24, MCH-1R, MCH1R, SLC-1, SLC1 2847 receptor 1 N 64 NMUR2 neuromedin U receptor 2 FM-4, FM4, NMU-R2, NMU2R, TGR-1, TGR1 56923 65 NPY1R neuropeptide Y receptor Y1 NPY1-R, NPYR 4886 O 66 OPRK1 opioid receptor, kappa 1 K-OR-1, KOR, KOR-1, OPRK 4986 olfactory receptor, family 51, 67 OR51E2 hCG_2044604, OR51E3P, OR52A2, PSGR 81285 subfamily E, member 2 olfactory receptor, family 7, subfamily 68 OR7A5 HTPCR2 26659 A, member 5 oxoglutarate (alpha-ketoglutarate) 69 OXGR1 GPR80, GPR99, P2RY15, P2Y15, aKGR 27199 receptor 1 purinergic receptor P2Y, G-protein P 70 P2RY1 P2Y1 5028 coupled, 1 purinergic receptor P2Y, G-protein 71 P2RY10 RP3-333E23.1, LYPSR2, P2Y10 27334 coupled, 10 purinergic receptor P2Y, G-protein 72 P2RY11 P2Y11 5032 coupled, 11 purinergic receptor P2Y, G-protein 73 P2RY14 BPR105, GPR105, P2Y14 9934 coupled, 14 pyrimidinergic receptor P2Y, G- 74 P2RY6 PP2891, P2Y6 5031 protein coupled, 6 75 PTAFR Platelet-activating factor receptor PAFR 5724 76 PTGDR prostaglandin D2 receptor (DP) AS1, ASRT1, DP, DP11, PTGDR 5729 R 77 RGR retinal G protein coupled receptor RP44 5995 S 78 S1PR1 sphingosine-1-phosphate receptor 1 CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1 1901 79 S1PR3 sphingosine-1-phosphate receptor 3 EDG-3, EDG3, LPB3, S1P3 1903 80 S1PR4 sphingosine-1-phosphate receptor 4 EDG6, LPC1, S1P4, SLP4 8698 3 PRO3GPCR-201408（Ⅰ） Human GPCR Expression List (n= 85) 2014/8/1 - No Official Symbol Official Full Name Aliases Gene ID 81 SSTR1 somatostatin receptor 1 SRIF-2, SS-1-R, SS1-R, SS1R 6751 T 82 TMEM11 transmembrane protein 11 PM1, PMI, C17orf35 8834 vasoactive intestinal peptide receptor HVR1, II, PACAP-R-2, PACAP-R2, RDC1, V1RG, VAPC1, VIP-R-1, V 83 VIPR1 7433 1 VIPR, VIRG, VPAC1, VPAC1R, VPCAP1R vasoactive intestinal peptide receptor tcag7.561, C16DUPq36.3, DUP7q36.3, PACAP-R-3, PACAP-R3, VIP-R- 84 VIPR2 7434 2 2, VPAC2, VPAC2R, VPCAP2R X 85 XCR1 chemokine (C motif) receptor 1 CCXCR1, GPR5 2829 4 PRO3GPCR-201408（Ⅰ）.
Load more

Recommended publications
  • Functional and Molecular Heterogeneity Of
    ARTICLE https://doi.org/10.1038/s41467-020-15716-9 OPEN Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum ✉ Emma Puighermanal1,2 , Laia Castell1, Anna Esteve-Codina 3, Su Melser4,5, Konstantin Kaganovsky 6, Charleine Zussy1, Jihane Boubaker-Vitre1, Marta Gut3,7, Stephanie Rialle1, Christoph Kellendonk8,9, Elisenda Sanz2, Albert Quintana 2, Giovanni Marsicano4,5, Miquel Martin1, Marcelo Rubinstein10,11,12, ✉ Jean-Antoine Girault 13,14,15, Jun B. Ding6 & Emmanuel Valjent 1 1234567890():,; Action control is a key brain function determining the survival of animals in their environ- ment. In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal striatum (DS) and the nucleus accumbens (Acb) jointly but differentially contribute to the fine reg- ulation of movement. However, their region-specific molecular features are presently unknown. By combining RNAseq of striatal D2R neurons and histological analyses, we identified hundreds of novel region-specific molecular markers, which may serve as tools to target selective subpopulations. As a proof of concept, we characterized the molecular identity of a subcircuit defined by WFS1 neurons and evaluated multiple behavioral tasks after its temporally-controlled deletion of D2R. Consequently, conditional D2R knockout mice displayed a significant reduction in digging behavior and an exacerbated hyperlocomotor response to amphetamine. Thus, targeted molecular analyses reveal an unforeseen hetero- geneity in D2R-expressing striatal neuronal populations, underlying specific D2R’s functional features in the control of specific motor behaviors. 1 IGF, CNRS, INSERM, Université Montpellier, Montpellier, France. 2 Neuroscience Institute, Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona, Bellaterra, Spain.
    [Show full text]
  • A Computational Approach for Defining a Signature of Β-Cell Golgi Stress in Diabetes Mellitus
    Page 1 of 781 Diabetes A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes Mellitus Robert N. Bone1,6,7, Olufunmilola Oyebamiji2, Sayali Talware2, Sharmila Selvaraj2, Preethi Krishnan3,6, Farooq Syed1,6,7, Huanmei Wu2, Carmella Evans-Molina 1,3,4,5,6,7,8* Departments of 1Pediatrics, 3Medicine, 4Anatomy, Cell Biology & Physiology, 5Biochemistry & Molecular Biology, the 6Center for Diabetes & Metabolic Diseases, and the 7Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202; 2Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202; 8Roudebush VA Medical Center, Indianapolis, IN 46202. *Corresponding Author(s): Carmella Evans-Molina, MD, PhD ([email protected]) Indiana University School of Medicine, 635 Barnhill Drive, MS 2031A, Indianapolis, IN 46202, Telephone: (317) 274-4145, Fax (317) 274-4107 Running Title: Golgi Stress Response in Diabetes Word Count: 4358 Number of Figures: 6 Keywords: Golgi apparatus stress, Islets, β cell, Type 1 diabetes, Type 2 diabetes 1 Diabetes Publish Ahead of Print, published online August 20, 2020 Diabetes Page 2 of 781 ABSTRACT The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We utilized an informatics-based approach to develop a transcriptional signature of β-cell GA stress using existing RNA sequencing and microarray datasets generated using human islets from donors with diabetes and islets where type 1(T1D) and type 2 diabetes (T2D) had been modeled ex vivo. To narrow our results to GA-specific genes, we applied a filter set of 1,030 genes accepted as GA associated.
    [Show full text]
  • See Also Figure 1
    Figure S1. Box-and-whisker plots depicting the range of expression values per developmental stage, with DESeq normalization (A) or quantile normalization (B). See also Figure 1. Figure S2. Lv-Setmar expression has low variation over developmental time. A. A plot of Lv-setmar versus Lv-ubiquitin expression over time demonstrates that Lv-setmar exhibits less temporal variation than Lv-ubiquitin. B. A representative gel showing Lv-setmar qPCR products amplified from cDNAs representing each sequenced stage in this study, demonstrating comparable product levels and an absence of spurious amplification products. See also Figure 1E. Figure S3. LvEDGE database. Screen shots showing the home page (A), the search window (B), an example search with a temporal expression plot (C), and the numerical data reflected in the plot (D) for the LvEDGE public database, which hosts the data described herein. stage 1 2 3 4 5 6 7 8 9 10 11 Category Subcategory 2-cell 60-cell EB HB TVP MB EG MG LG EP LP meiotic Cell Division Cytokinesis Mitosis checkpoint cell division recombination cell cycle stem cell left-right cell left-right Development maintenance asymmetry morphogenesis asymmetry regulation of multicellular organismal process cell soma cell soma Gene Expression chromatin SWI/SNF Control Chromatin modification chromatin binding complex methylated histone Binding negative sequence- sequence- sequence- regulation of sequence- specific DNA specific DNA specific DNA transcription specific DNA sequence-specific DNA binding binding binding binding factor activity
    [Show full text]
  • Supplementary Table S5. Differentially Expressed Gene Lists of PD-1High CD39+ CD8 Tils According to 4-1BB Expression Compared to PD-1+ CD39- CD8 Tils
    BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) J Immunother Cancer Supplementary Table S5. Differentially expressed gene lists of PD-1high CD39+ CD8 TILs according to 4-1BB expression compared to PD-1+ CD39- CD8 TILs Up- or down- regulated genes in Up- or down- regulated genes Up- or down- regulated genes only PD-1high CD39+ CD8 TILs only in 4-1BBneg PD-1high CD39+ in 4-1BBpos PD-1high CD39+ CD8 compared to PD-1+ CD39- CD8 CD8 TILs compared to PD-1+ TILs compared to PD-1+ CD39- TILs CD39- CD8 TILs CD8 TILs IL7R KLRG1 TNFSF4 ENTPD1 DHRS3 LEF1 ITGA5 MKI67 PZP KLF3 RYR2 SIK1B ANK3 LYST PPP1R3B ETV1 ADAM28 H2AC13 CCR7 GFOD1 RASGRP2 ITGAX MAST4 RAD51AP1 MYO1E CLCF1 NEBL S1PR5 VCL MPP7 MS4A6A PHLDB1 GFPT2 TNF RPL3 SPRY4 VCAM1 B4GALT5 TIPARP TNS3 PDCD1 POLQ AKAP5 IL6ST LY9 PLXND1 PLEKHA1 NEU1 DGKH SPRY2 PLEKHG3 IKZF4 MTX3 PARK7 ATP8B4 SYT11 PTGER4 SORL1 RAB11FIP5 BRCA1 MAP4K3 NCR1 CCR4 S1PR1 PDE8A IFIT2 EPHA4 ARHGEF12 PAICS PELI2 LAT2 GPRASP1 TTN RPLP0 IL4I1 AUTS2 RPS3 CDCA3 NHS LONRF2 CDC42EP3 SLCO3A1 RRM2 ADAMTSL4 INPP5F ARHGAP31 ESCO2 ADRB2 CSF1 WDHD1 GOLIM4 CDK5RAP1 CD69 GLUL HJURP SHC4 GNLY TTC9 HELLS DPP4 IL23A PITPNC1 TOX ARHGEF9 EXO1 SLC4A4 CKAP4 CARMIL3 NHSL2 DZIP3 GINS1 FUT8 UBASH3B CDCA5 PDE7B SOGA1 CDC45 NR3C2 TRIB1 KIF14 TRAF5 LIMS1 PPP1R2C TNFRSF9 KLRC2 POLA1 CD80 ATP10D CDCA8 SETD7 IER2 PATL2 CCDC141 CD84 HSPA6 CYB561 MPHOSPH9 CLSPN KLRC1 PTMS SCML4 ZBTB10 CCL3 CA5B PIP5K1B WNT9A CCNH GEM IL18RAP GGH SARDH B3GNT7 C13orf46 SBF2 IKZF3 ZMAT1 TCF7 NECTIN1 H3C7 FOS PAG1 HECA SLC4A10 SLC35G2 PER1 P2RY1 NFKBIA WDR76 PLAUR KDM1A H1-5 TSHZ2 FAM102B HMMR GPR132 CCRL2 PARP8 A2M ST8SIA1 NUF2 IL5RA RBPMS UBE2T USP53 EEF1A1 PLAC8 LGR6 TMEM123 NEK2 SNAP47 PTGIS SH2B3 P2RY8 S100PBP PLEKHA7 CLNK CRIM1 MGAT5 YBX3 TP53INP1 DTL CFH FEZ1 MYB FRMD4B TSPAN5 STIL ITGA2 GOLGA6L10 MYBL2 AHI1 CAND2 GZMB RBPJ PELI1 HSPA1B KCNK5 GOLGA6L9 TICRR TPRG1 UBE2C AURKA Leem G, et al.
    [Show full text]
  • Investigation of the Underlying Hub Genes and Molexular Pathogensis in Gastric Cancer by Integrated Bioinformatic Analyses
    bioRxiv preprint doi: https://doi.org/10.1101/2020.12.20.423656; this version posted December 22, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Investigation of the underlying hub genes and molexular pathogensis in gastric cancer by integrated bioinformatic analyses Basavaraj Vastrad1, Chanabasayya Vastrad*2 1. Department of Biochemistry, Basaveshwar College of Pharmacy, Gadag, Karnataka 582103, India. 2. Biostatistics and Bioinformatics, Chanabasava Nilaya, Bharthinagar, Dharwad 580001, Karanataka, India. * Chanabasayya Vastrad [email protected] Ph: +919480073398 Chanabasava Nilaya, Bharthinagar, Dharwad 580001 , Karanataka, India bioRxiv preprint doi: https://doi.org/10.1101/2020.12.20.423656; this version posted December 22, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Abstract The high mortality rate of gastric cancer (GC) is in part due to the absence of initial disclosure of its biomarkers. The recognition of important genes associated in GC is therefore recommended to advance clinical prognosis, diagnosis and and treatment outcomes. The current investigation used the microarray dataset GSE113255 RNA seq data from the Gene Expression Omnibus database to diagnose differentially expressed genes (DEGs). Pathway and gene ontology enrichment analyses were performed, and a proteinprotein interaction network, modules, target genes - miRNA regulatory network and target genes - TF regulatory network were constructed and analyzed. Finally, validation of hub genes was performed. The 1008 DEGs identified consisted of 505 up regulated genes and 503 down regulated genes.
    [Show full text]
  • Associations Among Dietary Non-Fiber Carbohydrate, Ruminal Microbiota
    Shen et al. Microbiome (2017) 5:123 DOI 10.1186/s40168-017-0341-z RESEARCH Open Access Associations among dietary non-fiber carbohydrate, ruminal microbiota and epithelium G-protein-coupled receptor, and histone deacetylase regulations in goats Hong Shen1,2†, Zhongyan Lu3*†, Zhihui Xu1,2, Zhan Chen1,2 and Zanming Shen3 Abstract Background: Diet-derived short-chain fatty acids (SCFAs) in the rumen have broad effects on the health and growth of ruminants. The microbe-G-protein-coupled receptor (GPR) and microbe-histone deacetylase (HDAC) axes might be the major pathway mediating these effects. Here, an integrated approach of transcriptome sequencing and 16S rRNA gene sequencing was applied to investigate the synergetic responses of rumen epithelium and rumen microbiota to the increased intake of dietary non-fiber carbohydrate (NFC) from 15 to 30% in the goat model. In addition to the analysis of the microbial composition and identification of the genes and signaling pathways related to the differentially expressed GPRs and HDACs, the combined data including the expression of HDACs and GPRs, the relative abundance of the bacteria, and the molar proportions of the individual SCFAs were used to identify the significant co-variation of the SCFAs, clades, and transcripts. Results: The major bacterial clades promoted by the 30% NFC diet were related to lactate metabolism and cellulose degradation in the rumen. The predominant functions of the GPR and HDAC regulation network, under the 30% NFC diet, were related to the maintenance of epithelium integrity and the promotion of animal growth. In addition, the molar proportion of butyrate was inversely correlated with the expression of HDAC1, and the relative abundance of the bacteria belonging to Clostridum_IV was positively correlated with the expression of GPR1.
    [Show full text]
  • Table 1A SIRT1 Differential Binding Gene List Down
    Rp1 Rb1cc1 Pcmtd1 Mybl1 Sgk3 Cspp1 Arfgef1 Cpa6 Kcnb2 Stau2 Jph1 Paqr8 Kcnq5 Rims1 Smap1 Bai3 Prim2 Bag2 Zfp451 Dst Uggt1 4632411B12Rik Fam178b Tmem131 Inpp4a 2010300C02Rik Rev1 Aff3 Map4k4 Il1r1 Il1rl2 Tgfbrap1 Col3a1 Wdr75 Tmeff2 Hecw2 Boll Plcl1 Satb2 Aox4 Mpp4 Gm973 Carf Nbeal1 Pard3b Ino80d Adam23 Dytn Pikfyve Atic Fn1 Smarcal1 Tns1 Arpc2 Pnkd Ctdsp1 Usp37 Acsl3 Cul3 Dock10 Col4a4 Col4a3 Mff Wdr69 Pid1 Sp110 Sp140 Itm2c 2810459M11Rik Dis3l2 Chrng Gigyf2 Ugt1a7c Ugt1a6b Hjurp A730008H23Rik Trpm8 Kif1a D1Ertd622e Pam Cntnap5b Rnf152 Phlpp1 Clasp1 Gli2 Dpp10 Tmem163 Zranb3 Pfkfb2 Pigr Rbbp5 Sox13 Ppfia4 Rabif Kdm5b Ppp1r12b Lgr6 Pkp1 Kif21b Nr5a2 Dennd1b Trove2 Pdc Hmcn1 Ncf2 Nmnat2 Lamc2 Cacna1e Xpr1 Tdrd5 Fam20b Ralgps2 Sec16b Astn1 Pappa2 Tnr Klhl20 Dnm3 Bat2l2 4921528O07Rik Scyl3 Dpt Mpzl1 Creg1 Cd247 Gm4846 Lmx1a Pbx1 Ddr2 Cd244 Cadm3 Fmn2 Grem2 Rgs7 Fh1 Wdr64 Pld5 Cep170 Akt3 Pppde1 Smyd3 Parp1 Enah Capn8 Susd4 Mosc1 Rrp15 Gpatch2 Esrrg Ptpn14 Smyd2 Tmem206 Nek2 Traf5 Hhat Cdnf Fam107b Camk1d Cugbp2 Gata3 Itih5 Sfmbt2 Itga8 Pter Rsu1 Ptpla Slc39a12 Cacnb2 Nebl Pip4k2a Abi1 Tbpl2 Pnpla7 Kcnt1 Camsap1 Nacc2 Gpsm1 Sec16a Fam163b Vav2 Olfm1 Tsc1 Med27 Rapgef1 Pkn3 Zer1 Prrx2 Gpr107 Ass1 Nup214 Bat2l Dnm1 Ralgps1 Fam125b Mapkap1 Hc Ttll11 Dennd1a Olfml2a Scai Arhgap15 Gtdc1 Mbd5 Kif5c Lypd6b Lypd6 Fmnl2 Arl6ip6 Galnt13 Acvr1 Ccdc148 Dapl1 Tanc1 Ly75 Gcg Kcnh7 Cobll1 Scn3a Scn9a Scn7a Gm1322 Stk39 Abcb11 Slc25a12 Metapl1 Pdk1 Rapgef4 B230120H23Rik Gpr155 Wipf1 Pde11a Prkra Gm14461 Pde1a Calcrl Olfr1033 Mybpc3 F2 Arhgap1 Ambra1 Dgkz Creb3l1
    [Show full text]
  • Supp Table 6.Pdf
    Supplementary Table 6. Processes associated to the 2037 SCL candidate target genes ID Symbol Entrez Gene Name Process NM_178114 AMIGO2 adhesion molecule with Ig-like domain 2 adhesion NM_033474 ARVCF armadillo repeat gene deletes in velocardiofacial syndrome adhesion NM_027060 BTBD9 BTB (POZ) domain containing 9 adhesion NM_001039149 CD226 CD226 molecule adhesion NM_010581 CD47 CD47 molecule adhesion NM_023370 CDH23 cadherin-like 23 adhesion NM_207298 CERCAM cerebral endothelial cell adhesion molecule adhesion NM_021719 CLDN15 claudin 15 adhesion NM_009902 CLDN3 claudin 3 adhesion NM_008779 CNTN3 contactin 3 (plasmacytoma associated) adhesion NM_015734 COL5A1 collagen, type V, alpha 1 adhesion NM_007803 CTTN cortactin adhesion NM_009142 CX3CL1 chemokine (C-X3-C motif) ligand 1 adhesion NM_031174 DSCAM Down syndrome cell adhesion molecule adhesion NM_145158 EMILIN2 elastin microfibril interfacer 2 adhesion NM_001081286 FAT1 FAT tumor suppressor homolog 1 (Drosophila) adhesion NM_001080814 FAT3 FAT tumor suppressor homolog 3 (Drosophila) adhesion NM_153795 FERMT3 fermitin family homolog 3 (Drosophila) adhesion NM_010494 ICAM2 intercellular adhesion molecule 2 adhesion NM_023892 ICAM4 (includes EG:3386) intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)adhesion NM_001001979 MEGF10 multiple EGF-like-domains 10 adhesion NM_172522 MEGF11 multiple EGF-like-domains 11 adhesion NM_010739 MUC13 mucin 13, cell surface associated adhesion NM_013610 NINJ1 ninjurin 1 adhesion NM_016718 NINJ2 ninjurin 2 adhesion NM_172932 NLGN3 neuroligin
    [Show full text]
  • Download (750Kb)
    The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa. Artur Pałasz a, Małgorzata Janas-Kozik b, Amanda Borrow c, Oscar Arias-Carrión d , John J. Worthington e a Department of Histology, School of Medicine in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland b Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, Medical University of Silesia, ul. Ziolowa 45/47 Katowice, 40-635, Poland c Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523- 161, US d Unidad de Trastornos del Movimiento y Sueño, Hospital General Dr Manuel Gea Gonzalez, Mexico City, Mexico e Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, LA1 4YQ, UK Abstract Due to the dynamic development of molecular neurobiology and bioinformatic methods several novel brain neuropeptides have been identified and characterized in recent years. Contemporary techniques of selective molecular detection e.g. in situ Real-Time PCR, microdiffusion and some bioinformatics strategies that base on searching for single structural features common to diverse neuropeptides such as hidden Markov model (HMM) have been successfully introduced. A convincing majority of neuropeptides have unique properties as well as a broad spectrum of physiological activity in numerous neuronal pathways including the hypothalamus and limbic system. The newly discovered but uncharacterized regulatory factors nesfatin-1, phoenixin, spexin and kisspeptin have the potential to be unique modulators of stress responses and eating behaviour. Accumulating basic studies revelaed an intriguing role of these neuropeptides in the brain pathways involved in the pathogenesis of anxiety behaviour.
    [Show full text]
  • G-Protein-Coupled Receptors in CNS: a Potential Therapeutic Target for Intervention in Neurodegenerative Disorders and Associated Cognitive Deficits
    cells Review G-Protein-Coupled Receptors in CNS: A Potential Therapeutic Target for Intervention in Neurodegenerative Disorders and Associated Cognitive Deficits Shofiul Azam 1 , Md. Ezazul Haque 1, Md. Jakaria 1,2 , Song-Hee Jo 1, In-Su Kim 3,* and Dong-Kug Choi 1,3,* 1 Department of Applied Life Science & Integrated Bioscience, Graduate School, Konkuk University, Chungju 27478, Korea; shofi[email protected] (S.A.); [email protected] (M.E.H.); md.jakaria@florey.edu.au (M.J.); [email protected] (S.-H.J.) 2 The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia 3 Department of Integrated Bioscience & Biotechnology, College of Biomedical and Health Science, and Research Institute of Inflammatory Disease (RID), Konkuk University, Chungju 27478, Korea * Correspondence: [email protected] (I.-S.K.); [email protected] (D.-K.C.); Tel.: +82-010-3876-4773 (I.-S.K.); +82-43-840-3610 (D.-K.C.); Fax: +82-43-840-3872 (D.-K.C.) Received: 16 January 2020; Accepted: 18 February 2020; Published: 23 February 2020 Abstract: Neurodegenerative diseases are a large group of neurological disorders with diverse etiological and pathological phenomena. However, current therapeutics rely mostly on symptomatic relief while failing to target the underlying disease pathobiology. G-protein-coupled receptors (GPCRs) are one of the most frequently targeted receptors for developing novel therapeutics for central nervous system (CNS) disorders. Many currently available antipsychotic therapeutics also act as either antagonists or agonists of different GPCRs. Therefore, GPCR-based drug development is spreading widely to regulate neurodegeneration and associated cognitive deficits through the modulation of canonical and noncanonical signals.
    [Show full text]
  • Molecular Programming of Tumor-Infiltrating CD8 T Cells and IL15 Resistance
    Published OnlineFirst August 2, 2016; DOI: 10.1158/2326-6066.CIR-15-0178 Research Article Cancer Immunology Research Molecular Programming of Tumor-Infiltrating CD8þ T Cells and IL15 Resistance Andrew L. Doedens1, Mark P. Rubinstein1,2, Emilie T. Gross3, J. Adam Best1, David H. Craig2, Megan K. Baker2, David J. Cole2, Jack D. Bui3, and Ananda W. Goldrath1 Abstract Despite clinical potential and recent advances, durable immu- in the lung and spleen were activated and dramatically expanded. þ notherapeutic ablation of solid tumors is not routinely achieved. Tumor-infiltrating CD8 T cells exhibited cell-extrinsic and cell- IL15expandsnaturalkillercell(NK),naturalkillerTcell(NKT)and intrinsic resistance to IL15. Our data showed that in the case of þ CD8 T-cell numbers and engages the cytotoxic program, and thus persistent viral or tumor antigen, single-agent systemic IL15cx is under evaluation for potentiation of cancer immunotherapy. We treatment primarily expanded antigen-irrelevant or extratumoral þ found that short-term therapy with IL15 bound to soluble IL15 CD8 Tcells.Weidentified exhaustion, tissue-resident memory, þ receptor a–Fc (IL15cx; a form of IL15 with increased half-life and and tumor-specific molecules expressed in tumor-infiltrating CD8 activity) was ineffective in the treatment of autochthonous PyMT T cells, which may allow therapeutic targeting or programming þ murine mammary tumors, despite abundant CD8 T-cell infiltra- of specific subsets to evade loss of function and cytokine resist- tion. Probing of this poor responsiveness revealed that IL15cx ance, and, in turn, increase the efficacy of IL2/15 adjuvant cytokine þ only weakly activated intratumoral CD8 T cells, even though cells therapy.
    [Show full text]
  • Activation of the Orphan G Protein–Coupled Receptor GPR27 by Surrogate Ligands Promotes B-Arrestin 2 Recruitment S
    Supplemental material to this article can be found at: http://molpharm.aspetjournals.org/content/suppl/2017/03/17/mol.116.107714.DC1 1521-0111/91/6/595–608$25.00 https://doi.org/10.1124/mol.116.107714 MOLECULAR PHARMACOLOGY Mol Pharmacol 91:595–608, June 2017 Copyright ª 2017 by The American Society for Pharmacology and Experimental Therapeutics Activation of the Orphan G Protein–Coupled Receptor GPR27 by Surrogate Ligands Promotes b-Arrestin 2 Recruitment s Nadine Dupuis, Céline Laschet, Delphine Franssen, Martyna Szpakowska, Julie Gilissen, Pierre Geubelle, Arvind Soni, Anne-Simone Parent, Bernard Pirotte, Andy Chevigné, Jean- Claude Twizere, and Julien Hanson Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases (N.D., C.L., J.G., P.G., A.S., J.H.), Laboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (N.D., B.P., J.H.), Neuroendocrinology Unit, GIGA- Neurosciences (D.F., A.-S.P.), Laboratory of Protein Signaling and Interactions, GIGA-Molecular Biology of Diseases (J.-C.T.), Downloaded from University of Liège, Liège, Belgium; and Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur- Alzette, Luxembourg (M.S., A.C.) Received December 6, 2016; accepted March 16, 2017 ABSTRACT molpharm.aspetjournals.org Gprotein–coupled receptors are the most important drug targets the presence of membrane-anchored G protein-coupled receptor for human diseases. An important number of them remain devoid kinase-2. Therefore, we optimized a firefly luciferase complemen- of confirmed ligands. GPR27 is one of these orphan receptors, tation assay to screen against this chimeric receptor. We identified characterized by a high level of conservation among vertebrates two compounds [N-[4-(anilinocarbonyl)phenyl]-2,4-dichloroben- and a predominant expression in the central nervous system.
    [Show full text]