VII. MEDICATIONS to AVOID (Do Not Take These Medications)
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United States Patent (19) (11) 4,232,002 Nogrady 45) Nov
United States Patent (19) (11) 4,232,002 Nogrady 45) Nov. 4, 1980 (54) PROCEDURES AND PHARMACEUTICAL (56) References Cited PRODUCTS FOR USE IN THE PUBLICATIONS ADMINISTRATION OF ANTHISTAMINES American Hospital Formulary Service, 1966, 4:00 Anti (75. Inventor: Stephen G. Nogrady, Sully, near histamine Drugs, Penarth, Great Britain Primary Examiner-Stanley J. Friedman Attorney, Agent, or Firm-Young & Thompson 73) Assignee: The Welsh National School of Medicine, Penarth, Great Britain 57 ABSTRACT An antihistamine of the benzhydrylether, alkylamine, or (21) Appl. No.: 965,171 benzocyloheptatiophene class is suitable for use in the therapeutic treatment or prophylaxis of reversible air (22 Filed: Nov.30, 1978 ways obstruction by inhalation. The antihistamine may be clemastine, chlorpheniramine or ketotifen and may (30) Foreign Application Priority Data be in the form of a composition in admixture with a diluent. The antihistamine can be administered from a Dec. 1, 1977 GB) United Kingdom ..................... 5.0020 pharmaceutical inhalation device which is designed to 51 Int. Cl. ......................... A61L 9/04; A61 K9/04; administer a dosage unit of the antihistamine. The inha A61K 31/44 lation device can be in the form of a pressurized aerosol 52 U.S. C. ........................................ 424/45; 424/46; inhaler or a dry powder insufflator. 424/263 58) Field of Search ............................ 424/263, 46, 45 5 Claims, No Drawings 4,232,002 1. 2 inhalation provides the equivalent of 0.1 to 5 mg. of PROCEDURES AND PHARMACEUTICAL clemastine, or 0.05 to 2.5 mg. of chlorpheniramine. The PRODUCTS FOR USE IN THE ADMINISTRATION drug may be inhaled in the form of a mist or nebulized OF ANTHISTAMINES spray, or as a cloud of fine solid particles, and may be inhaled from a variety of inhaler devices. -
Antihistamine Therapy in Allergic Rhinitis
CLINICAL REVIEW Antihistamine Therapy in Allergic Rhinitis Paul R. Tarnasky, MD, and Paul P. Van Arsdel, Jr, MD Seattle, Washington Allergic rhinitis is a common disorder that is associated with a high incidence of mor bidity and considerable costs. The symptoms of allergic rhinitis are primarily depen dent upon the tissue effects of histamine. Antihistamines are the mainstay of therapy for allergic rhinitis. Recently, a second generation of antihistamines has become available. These agents lack the adverse effect of sedation, which is commonly associated with older antihistamines. Current practice of antihistamine therapy in allergic rhinitis often involves random selection among the various agents. Based upon the available clinical trials, chlorpheniramine appears to be the most reasonable initial antihistaminic agent. A nonsedating antihis tamine should be used initially if a patient is involved in activities where drowsiness is dangerous. In this comprehensive review of allergic rhinitis and its treatment, the cur rent as well as future options in antihistamine pharmacotherapy are emphasized. J Fam Pract 1990; 30:71-80. llergic rhinitis is a common condition afflicting some defined by the period of exposure to those agents to which A where between 15 and 30 million people in the United a patient is sensitive. Allergens in seasonal allergic rhinitis States.1-3 The prevalence of disease among adolescents is consist of pollens from nonflowering plants such as trees, estimated to be 20% to 30%. Two thirds of the adult grasses, and weeds. These pollens generally create symp allergic rhinitis patients are under 30 years of age.4-6 Con toms in early spring, late spring through early summer, sequently, considerable costs are incurred in days lost and fall, respectively. -
San Juan County Adult Drug Court Participant Handbook
Participant Manual SEVENTH DISTRICT ADULT DRUG COURT MONTICELLO, UTAH Updated January 2018 Subject to Change 1 2 Welcome to the San Juan County Adult Drug Court This Handbook is designed to introduce you to the San Juan County Drug Court program, answer your questions and provide overall information about the Drug Court Program. As a participant, you will be expected to follow the instructions given in Drug Court by the Judge and comply with the treatment plan developed for you by the treatment team. If you are reading this Handbook it means that we are confident that Drug Court will help you to learn how to make successful choices free of the influence of drugs or alcohol. 3 Table of Contents Welcome to the San Juan County Adult Drug Court ...................................................................... 3 Overview ....................................................................................................................................... 6 Drug Court Team ........................................................................................................................... 7 Judge’s Role ........................................................................................................................... 7 San Juan County Attorney’s Role (Prosecutor) ....................................................................... 8 Defense Attorney Role (Your Attorney) ................................................................................... 8 Probation Officer’s Role ......................................................................................................... -
Medicines Classification Committee
Medicines Classification Committee Meeting date 1 May 2017 58th Meeting Title Reclassification of Sedating Antihistamines Medsafe Pharmacovigilance Submitted by Paper type For decision Team Proposal for The Medicines Adverse Reactions Committee (MARC) recommended that the reclassification to committee consider reclassifying sedating antihistamines to prescription prescription medicines when used in children under 6 years of age for the treatment of medicine for some nausea and vomiting and travel sickness [exact wording to be determined by indications the committee]. Reason for The purpose of this document is to provide the committee with an overview submission of the information provided to the MARC about safety concerns associated with sedating antihistamines and reasons for recommendations. Associated March 2013 Children and Sedating Antihistamines Prescriber Update articles February 2010 Cough and cold medicines clarification – antihistamines Medsafe website Safety information: Use of cough and cold medicines in children – new advice Medicines for Alimemazine Diphenhydramine consideration Brompheniramine Doxylamine Chlorpheniramine Meclozine Cyclizine Promethazine Dexchlorpheniramine New Zealand Some oral sedating antihistamines available without exposure to a prescription (pharmacist-only and pharmacy only), sedating therefore usage data is not easily available. antihistamines Table of Contents 1.0 PURPOSE ...................................................................................................................................... -
The Impact of NMR and MRI
WELLCOME WITNESSES TO TWENTIETH CENTURY MEDICINE _____________________________________________________________________________ MAKING THE HUMAN BODY TRANSPARENT: THE IMPACT OF NUCLEAR MAGNETIC RESONANCE AND MAGNETIC RESONANCE IMAGING _________________________________________________ RESEARCH IN GENERAL PRACTICE __________________________________ DRUGS IN PSYCHIATRIC PRACTICE ______________________ THE MRC COMMON COLD UNIT ____________________________________ WITNESS SEMINAR TRANSCRIPTS EDITED BY: E M TANSEY D A CHRISTIE L A REYNOLDS Volume Two – September 1998 ©The Trustee of the Wellcome Trust, London, 1998 First published by the Wellcome Trust, 1998 Occasional Publication no. 6, 1998 The Wellcome Trust is a registered charity, no. 210183. ISBN 978 186983 539 1 All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/ Please cite as : Tansey E M, Christie D A, Reynolds L A. (eds) (1998) Wellcome Witnesses to Twentieth Century Medicine, vol. 2. London: Wellcome Trust. Key Front cover photographs, L to R from the top: Professor Sir Godfrey Hounsfield, speaking (NMR) Professor Robert Steiner, Professor Sir Martin Wood, Professor Sir Rex Richards (NMR) Dr Alan Broadhurst, Dr David Healy (Psy) Dr James Lovelock, Mrs Betty Porterfield (CCU) Professor Alec Jenner (Psy) Professor David Hannay (GPs) Dr Donna Chaproniere (CCU) Professor Merton Sandler (Psy) Professor George Radda (NMR) Mr Keith (Tom) Thompson (CCU) Back cover photographs, L to R, from the top: Professor Hannah Steinberg, Professor -
LITERATURE REVIEW Drug Review
LITERATURE REVIEW Drug Review Document ID: N04-023 Author: Julie Qidwai Date: December 2004 National Advanced Driving Simulator 2401 Oakdale Blvd. Iowa City, IA 52242-5003 Fax (319) 335-4658 TABLE OF CONTENTS 1 Introduction ............................................................................................................................ 1 2 Alprazolam.............................................................................................................................. 1 3 Amitriptyline........................................................................................................................... 2 4 Biperiden................................................................................................................................. 2 5 Brompheniramine .................................................................................................................. 2 6 Butorphanol ............................................................................................................................ 2 7 Cetirizine................................................................................................................................. 3 8 Chloroquine ............................................................................................................................ 3 9 Chlorpheniramine .................................................................................................................. 4 10 Clemastine.............................................................................................................................. -
Identification of SARS-Cov-2 Entry Inhibitors Among Already Approved
www.nature.com/aps ARTICLE Identification of SARS-CoV-2 entry inhibitors among already approved drugs Li Yang1, Rong-juan Pei2, Heng Li1,3, Xin-na Ma4, Yu Zhou1, Feng-hua Zhu1, Pei-lan He1, Wei Tang1, Ye-cheng Zhang2, Jin Xiong2, Shu-qi Xiao2, Xian-kun Tong1, Bo Zhang2 and Jian-ping Zuo1,3,4 To discover effective drugs for COVID-19 treatment amongst already clinically approved drugs, we developed a high throughput screening assay for SARS-CoV-2 virus entry inhibitors using SARS2-S pseudotyped virus. An approved drug library of 1800 small molecular drugs was screened for SARS2 entry inhibitors and 15 active drugs were identified as specific SARS2-S pseudovirus entry inhibitors. Antiviral tests using native SARS-CoV-2 virus in Vero E6 cells confirmed that 7 of these drugs (clemastine, amiodarone, trimeprazine, bosutinib, toremifene, flupenthixol, and azelastine) significantly inhibited SARS2 replication, reducing supernatant viral RNA load with a promising level of activity. Three of the drugs were classified as histamine receptor antagonists with clemastine showing the strongest anti-SARS2 activity (EC50 = 0.95 ± 0.83 µM). Our work suggests that these 7 drugs could enter into further in vivo studies and clinical investigations for COVID-19 treatment. Keywords: COVID-19; SARS-CoV-2; virus entry inhibitors; high throughput screening assay; approved drug library; histamine receptor antagonists; clemastine 1234567890();,: Acta Pharmacologica Sinica (2021) 42:1347–1353; https://doi.org/10.1038/s41401-020-00556-6 INTRODUCTION drugs with high activity and specificity that will be of critical Since the outbreak of COVID-19, there have been ~15 million benefit for our long-term control of this emerging disease. -
Clemastine San Francisco, CA 94158 Tel: (415) 353-2069 Fax: (415) 353-2633 Steven Merrill, Pharmd, MSCS Patient Information
Center for Multiple Sclerosis & Neuroinflammation 1500 Owens Street, Suite 320 Clemastine San Francisco, CA 94158 Tel: (415) 353-2069 Fax: (415) 353-2633 Steven Merrill, PharmD, MSCS Patient Information Updated: 10.2019 USED FOR Relapsing and progressive forms of multiple sclerosis (MS). It is hoped that this medicine helps to repair some of the injury to myelin and nerve fibers seen in MS. HOW IT WORKS Clemastine is typically used as an allergy medicine to help relieve symptoms such as sneezing, watery eyes, runny nose, and itching. For MS, clemastine has been shown to help damaged nerve cells re-grow myelin, which helps nerve cells work faster and better. HOW IT IS SUPPLIED Clemastine 1.34 mg tablet or 2.68 mg tablet. May be purchased without a prescription, over-the-counter (OTC) at most drug stores. May be compounded at certain compounding pharmacies at an additional cost. HOW IT IS GIVEN Clemastine tablets may be taken with or without food. It may be taken safely with other disease-modifying therapies for MS. DOSE 2 tablets (5.36 mg) taken by mouth twice daily STORAGE Clemastine may be kept at room temperature, away from direct sunlight, extreme heat, or cold. This information is for educational purposes only and is not intended to replace the advice of your doctor or health care provider. We encourage you to discuss with your doctor any questions or concerns you may have. Center for Multiple Sclerosis & Neuroinflammation COMMON SIDE Drowsiness, Fatigue EFFECTS Dry mouth Urinary retention, constipation Dizziness Headache Some people with MS who are older may be more sensitive to these side effects than others. -
(12) United States Patent (10) Patent No.: US 8.497,369 B2 Himmelsbach Et Al
US008497369B2 (12) United States Patent (10) Patent No.: US 8.497,369 B2 Himmelsbach et al. (45) Date of Patent: Jul. 30, 2013 (54) SPIROCYCLIC HETEROCYCLES 5,929,080 A 7, 1999 Frost MEDCAMENTS CONTAINING SAD 5,938,706 A 8, 1999 Feldman 5,962,458 A 10, 1999 Lohmann et al. COMPOUNDS, USE THEREOF AND METHOD 6,004,967 A 12/1999 McMahon et al. FOR THEIR PRODUCTION 6,046,206 A 4/2000 Pamukcu et al. 6,117,433 A 9, 2000 Edens et al. 6,126,917 A 10/2000 Mishani et al. (75) Inventors: Frank Himmelsbach, Mittelbiberach 6,177,433 B1 1/2001 Uckun et al. (DE); Birgit Jung, Laupheim (DE); Ralf 6,225,318 B1 5/2001 Sobolov-Jaynes et al. Lotz, Schemmerhofen (DE) 6,270,747 B1 8, 2001 Nadel et al. 6,297.258 B1 10/2001 Wissner et al. (73) Assignee: Boehringer Ingelheim International 6,313,130 B1 1 1/2001 Uckun et al. 6,326,373 B1 12/2001 Uckun et al. GmbH, Ingelheim am Rhein (DE) 6,362,336 B1 3/2002 Lohmann et al. 6,384.223 B1 5, 2002 GletSos (*) Notice: Subject to any disclaimer, the term of this 6,399,602 B1 6/2002 Barker et al. patent is extended or adjusted under 35 6,403,580 B1 6/2002 Himmelsbach et al. 6,414,148 B1 7/2002 Thomas et al. U.S.C. 154(b) by 331 days. 6,551,989 B2 4/2003 Nadel et al. 6,562,319 B2 5/2003 Mishani et al. -
PHARMACEUTICAL APPENDIX to the HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2008) (Rev
Harmonized Tariff Schedule of the United States (2008) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2008) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM GADOCOLETICUM 280776-87-6 ABAFUNGIN 129639-79-8 ACIDUM LIDADRONICUM 63132-38-7 ABAMECTIN 65195-55-3 ACIDUM SALCAPROZICUM 183990-46-7 ABANOQUIL 90402-40-7 ACIDUM SALCLOBUZICUM 387825-03-8 ABAPERIDONUM 183849-43-6 ACIFRAN 72420-38-3 ABARELIX 183552-38-7 ACIPIMOX 51037-30-0 ABATACEPTUM 332348-12-6 ACITAZANOLAST 114607-46-4 ABCIXIMAB 143653-53-6 ACITEMATE 101197-99-3 ABECARNIL 111841-85-1 ACITRETIN 55079-83-9 ABETIMUSUM 167362-48-3 ACIVICIN 42228-92-2 ABIRATERONE 154229-19-3 ACLANTATE 39633-62-0 ABITESARTAN 137882-98-5 ACLARUBICIN 57576-44-0 ABLUKAST 96566-25-5 ACLATONIUM NAPADISILATE 55077-30-0 ABRINEURINUM 178535-93-8 ACODAZOLE 79152-85-5 ABUNIDAZOLE 91017-58-2 ACOLBIFENUM 182167-02-8 ACADESINE 2627-69-2 ACONIAZIDE 13410-86-1 ACAMPROSATE -
Medications to Avoid Before Skin Testing
PLEASE STOP ANTIHISTAMINES 5 DAYS PRIOR TO NEW PATIENT APPOINTMENTS OR ALLERGY SKIN TESTING *Do not stop asthma medications or any other medications that do not contain antihistamine! **If you have major hives or swelling, do not stop your antihistamines. ***Please call us if you have questions about any of your medications interfering with skin testing. ****Do not use oil, cream or lotion on the back or arms for 24 hours prior to skin testing. COMMON MEDICATIONS CONTAINING ANTIHISTAMINES • Actifed (chlorpheniramine) • Elavil (amitriptyline) • Advil PM, Advil Allergy • Excedrin PM • Alavert/Claritin (loratadine) • Fexofenadine (Allegra) • Allegra (fexofenadine) • Hydroxyzine (Atarax, Vistaril) • Alka Seltzer P.M. • Imipramine (Tofranil) • Amitriptyline (Elavil) • Levocetirizine (Xyzal) • Antivert (Meclizine) • Loratadine (Claritin) • Astelin Nasal Spray (azelastine) • Meclizine (Antivert, Bonine) • Astepro Nasal Spray (azelastine) • Norpramine (desipramine) • Atarax (hydroxyzine) • Nortriptyline (Pamelor) • Azelastine nose spray (Astepro, Astelin) • Nyquil • Benadryl (diphenhydramine) • Nytol • Bonine (meclizine) • Olopatadine (Patanase nasal spray) • Cetirizine (Zyrtec) • Pamelor (nortriptyline) • Chlorpheniramine (Chlor-Trimeton, Actifed, • Patanase Nasal Spray (olopatadine) Tussionex) • PBZ (pyribenzamine) • Chlor-Trimeton (chlorpheniramine) • Pediacare • Clarinex (desloratadine) • Periactin (Cyproheptadine) • Claritin (loratadine) • Phenergan (promethazine) • Clemastine (Tavist) • Promethazine (Phenergan) • Cogentin (for Parkinson's -
The Relation Between Antihistamine Medication During Early Pregnancy & Birth Defects
The Egyptian Journal of Medical Human Genetics (2015) 16, 287–290 HOSTED BY Ain Shams University The Egyptian Journal of Medical Human Genetics www.ejmhg.eg.net www.sciencedirect.com REVIEW The relation between antihistamine medication during early pregnancy & birth defects Rabah M. Shawky a,*, Neveen S. Seifeldin b a Genetics Unit, Pediatric Department, Ain Shams University, Egypt b Dermatology, Venereology and Andrology Department, Ain Shams University, Egypt Received 6 April 2015; accepted 16 April 2015 Available online 11 May 2015 KEYWORDS Abstract Antihistamines are a group of medications which can inhibit various histaminic actions Antihistamine; at one of two histamine receptors (H1 or H2). H1 receptor antagonists are used for the relief of Birth defects; allergic dermatological and nondermatological conditions. We will review classes of antihistamines Congenital malformation; (H1 antagonists) and the relationship between specific antihistamines and specific birth defects. H1 antagonist; Although many findings provide reassurance about the relative safety of many antihistamine drugs Early pregnancy; and that any malformation reported is most probably caused by chance, studies are still required to Dermatological conditions assure fetal safety. As pruritus is sometimes troublesome for pregnant women topical medications like emollients should be tried first in the first trimester of pregnancy. Also pregnant women should be advised to consult their health care provider before taking any medication. Ó 2015 Production and hosting by Elsevier B.V. on behalf of Ain Shams University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Contents 1. Introduction . 287 2. Classification of H1 antihistamines .