Annual Meeting of the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS 2016)

The Great SCIentific eXchange SCIX2016

And the National Meeting of the Society for Applied Spectroscopy (SAS)

Minneapolis, Minnesota, USA 18 - 23 September 2016

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Curran Associates, Inc. 57 Morehouse Lane Red Hook, NY 12571 USA Phone: 845-758-0400 Fax: 845-758-2633 Email: [email protected] Web: www.proceedings.com TABLE OF CONTENTS

SUNDAY EVENING KEYNOTE LECTURE

DEMOCRATIZATION OF NEXT-GENERATION MICROSCOPY, SENSING AND DIAGNOSTICS TOOLS THROUGH COMPUTATIONAL PHOTONICS ...... 1 Aydogan Ozcan

SPECTROSCOPY MAGAZINE'S EMERGING LEADER IN MOLECULAR SPECTROSCOPY AWARD PLENARY

SERUM SPECTROSCOPIC DIAGNOSTICS: THE FUTURE FOR CLINICAL DIAGNOSTICS?...... 2 Matthew Baker

ITP PLENARY LECTURE

CAPILLARY ELECTROPHORESIS FOR BOTTOM-UP PROTEOMIC ANALYSIS OF COMPLEX MIXTURES...... 2 Norman Dovichi, Liangliang Sun, Guijie Zhu

FUNDAMENTALS AND NOVEL APPLICATIONS OF GLOW DISCHARGE SPECTROSCOPY

COMPRESSED SENSING SPECTRAL IMAGING COUPLED TO GLOW DISCHARGE OPTICAL EMISSION ELEMENTAL MAPPING ...... 3 Gerardo Gamez, John Usala, Adrian Maag, Thomas Nelis

PULSED RADIOFREQUENCY GLOW DISCHARGE TIME-OF-FLIGHT MASS SPECTROMETRY: A VERSATILE ANALYTICAL TECHNIQUE FOR FAST DIRECT SOLID AND GAS ANALYSIS...... 3 Jorge Pisonero, Jonatan Fandiño, David Blanco, Alfredo Sanz-Medel, Nerea Bordel

THE REALIZATION OF A NEW SOLID-STATE SPECTROMETER FOR GLOW DISCHARGE OPTICAL EMISSION ...... 4 Kim Marshall, Greg Schilling

USE OF DIFFERENTIAL INTERFEROMETRY FOR DIRECT MEASUREMENT OF DEPTH WITH GD-OES, A MAJOR STEP FOR THE TECHNIQUE...... 5 Matthieu Chausseau, Patrick Chapon, Sofia Gaiaschi, Simon Richard, Kayvon Savadkouei, Philippe Hunault

TRACE DETECTION IN FORENSICS

HOMEMADE EXPLOSIVES DETECTION ...... 5 Hacene Boudries, Edita Botonjic-Sehic, Vinh Lam

THE USE OF FTIR FOR THE DETECTION OF CHEMICAL WARFARE AGENTS AND TOXIC INDUSTRIAL CHEMICALS ...... 6 Larry McDermott, Mario Tongol, Norm Smith

SOLVENT EFFECTS IN API MASS SPECTROMETRY ...... 6 Jimmie Oxley

COMMERCIAL RODENTICIDE REPOSITORY AND ATTRIBUTION SIGNATURES...... 7 Evan Durnal, Krista Brady

MOLECULAR SPECTROSCOPY – SELECTED CONTRIBUTED PAPERS

RE-INVENTION OF ROTATIONAL SPECTROSCOPY - FT-MRR FOR DIRECT COMPOSITION ANALYSIS OF COMPLEX MIXTURES ...... 7 Brent J. Harris, Shelby S. Fields, Robin L. Pulliam, Justin L. Neill, Matthew T. Muckle, Linda H. Kidder

MICROSCOPIC IMAGING OF STRUCTURAL HETEROGENEITY IN COLLAGENOUS TISSUE BY NONLINEAR OPTICAL STOKES ELLIPSOMETRY...... 8 Garth Simpson, Ximeng Y. Dow, Emma L. Kerian, Shane Z. Sullivan, James R. W. Ulcickas

PHOTOACOUSTIC FTIR SPECTROSCOPY OF WEATHERED THERMOPLASTICS...... 8 Michael Hall, Nancy Jestel, Pooja Bajaj, Eric Jiang

A NEW INSIGHT TO UNDERSTAND THE DISEASE PATHOLOGY OF BREAST CANCER BY MULTIMODAL SPECTROSCOPIC MODALITIES...... 9 Saroj Kumar, Xia Liu, Erik Goormaghtigh, Fredrik Nikolajeff

QUANTITATIVE ANALYSIS OF SEPARATED PAGE PROTEINS BY NEAR INFRARED SPECTRAL IMAGING ...... 10 Arash Hanifi, Nancy Pleshko

ELECTROPHORESIS – INSTRUMENTATION AND DETECTION

SEARCHING FOR SIGNS OF LIFE WITH ELECTROPHORESIS...... 11 Peter Willis, Maria Mora, Jessica Creamer, Florian Kehl, Eric Tavares Da Costa

OPTICAL/ELECTROCHEMICAL BIOSENSING USING MICROMOTORS AS NOVEL ANALYTICAL TOOLS...... 11 Beatriz Jurado-Sánchez, Alberto Escarpa

LOCALIZED SURFACE PLASMON RESONANCE - A NOVEL TECHNIQUE FOR STUDYING INTERACTIONS BETWEEN IONIC LIQUIDS AND LIPID VESICLES...... 12 Susanne Wiedmer, Joanna Witos, Suvi-Katriina Ruokonen

SIMPLE AND LOW-COST POINT-OF-NEED DETECTION BY AC ELECTROKINETICS-BASED CAPACITIVE BIOSENSOR ...... 13 Jayne Wu, Jiangang Chen, Shigetoshi Eda, Cheng Cheng, Rania Oueslati

DIELECTROPHORESIS I - FUNDAMENTALS

ENGINEERING NONLINEAR ELECTROKINETIC FLOWS AT POLARIZABLE INTERFACES...... 14 Zachary Gagnon

DIELECTROPHORESIS: AN ALTERNATIVE TO CHROMATOGRAPHIC TECHNIQUES ...... 14 Sagnik Basuray

ENHANCEMENT OF DIELECTROPHORESIS USING ROUGH ELECTRODES ...... 15 Ali Beskok

ENABLING CELL CO-CULTURE AND CELL MIGRATION STUDIES IN MICROFLUIDIC SYSTEMS ...... 16 Darwin R. Reyes

LIBS IMAGING

LATERALLY RESOLVED ANALYSIS OF STEELS USING LIBS: REVEALING THE DISTRIBUTION OF METALLIC AND NON-METALLIC ADDITIONS ...... 17 Maximilian Bonta, Raquel De Oro Calderon, Christian Gierl-Mayr, Herbert Danninger, Andreas Limbeck

LASER INDUCED BREAKDOWN SPELASER INDUCED BREAKDOWN SPECTROSCOPY FOR HIGH RESOLUTION MAPPING OF CORE SAMPLES...... 17 Francisco Lopez-Linares, C. Derrick Quarles Jr., Toni Miao, Laura Poirier, Jhanis J. Gonzalez

ROLE OF INTERFACIAL PLASMA SEPARATION AND MIXING PROCESSES IN THREE-DIMENSIONAL CHEMICAL IMAGING WITH FEMTOSECOND LIBS ...... 18 Vassilia Zorba, Ran Hai, Xianglei Mao, Richard Russo

THE TORTUOUS ISSUES OF DATA ANALYSIS IN LIBS IMAGING...... 18 Vincent Motto-Ros, Florian Trichard, Jörg Hermann, Bruno Bousquet, Frédéric Pélascini

LASER INDUCED BREAKDOWN SPECTROSCOPY OF SIMULATED USED NUCLEAR FUEL ...... 19 Keri Campbell, Elizabeth Judge, James Barefield II, James Colgan, David Kilcrease

SEMICONDUCTING NANOMATERIALS FOR SOLAR ENERGY APPLICATIONS

ULTRAFAST LASER SPECTROSCOPY OF TWO-DIMENSIONAL MATERIALS AND THEIR HETEROSTRUCTURES...... 20 Hui Zhao, Yongsheng Wang, Dawei He

SPECTROSCOPY OF QUANTUM DOT SOLAR ENERGY CONVERSION SYSTEMS ...... 20 Matthew Beard, Daniel Kroupa, Yong Yan, Boris Chernomorkik, Jao Van De Lagemaat, Jianbing Zhang, Ashley Marshall, Joseph Luther

ELECTRONIC AND EXCITONIC PROPERTIES OF MONOLAYER MOLYBDENUM DISULFIDE / TUNGSTEN DISULFIDE INTERFACES ...... 21 James Johns, Youngdong Yoo, Zachary Degregorio, Aaron Schulzetenberg

INVESTIGATION OF TRANSITION METAL DICHALCOGENIDE EXCITON DYNAMICS USING STATE- SELECTIVE MULTIDIMENSIONAL SPECTROSCOPY ...... 22 Kyle Czech, Blaise Thompson, Song Jin, John Wright

CARRIER DECAY PROCESS IN ALLOYED [HC(NH2)2]1-X[CH3NH3]XPBI3 NANOSTRUCTURES...... 22 Jun Jun Dai

RAMAN AND NIR SCREENING OF SMALL MOLECULES AND BIOLOGICS BASED COUNTERFEITS

RAMAN SCREENING OF FINISHED MEDICINES USING SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS)-BASED APPROACHES ...... 23 Latevi Lawson, Chelliah Navin, Jason Rodriguez

PAST, PRESENT AND FUTURE ANALYTICAL TECHNIQUES TO SCREEN COUNTERFEIT DRUGS...... 23 Ravi Kalyanaraman

OPTIMIZING DETECTION OF MILK PROTEIN ADULTERANTS UTILIZING A CUSTOM SERS SUBSTRATE ...... 24 Milo Overbay, Anita Rogacs, Viktor Shkolnikov, Michael Delos-Reyes

FLUORESCENCE SUPPRESSED TIME RESOLVED RAMAN SPECTROSCOPY OF ADULTERATED HERBAL PRODUCTS ...... 25 Clare Strachan, Sara Miller, Friederike Folttmann, Keith Gordon, Mari Tenhunen

AN APPLICATION OF RAPID DETECTION TECHNOLOGIES IN A NATIONAL REGULATORY LABORATORY SETTING: DIFFERENTIATING IMPORTED AND DOMESTIC DRUG PRODUCTS OF OXCABAZEPINE USING HANDHELD RAMAN, NEAR INFRARED, AND PORTABLE FTIR ANALYZERS...... 26 Bei Ma, Lingbo Wang

EMERGING RAMAN I

A MULTIFOCAL APPROACH FOR PARALLEL HYPERSPECTRAL DETECTION IN CONFOCAL RAMAN MICROSCOPY ...... 26 James Chan, Maria Navas-Moreno, Lingbo Kong

COHERENT RAMAN IMAGING OF PHEOMELANIN ...... 27 Conor Evans, Tracy Wang, Sam Osseiran, Vivien Ingras, Alexander Nichols, Elizabth Roider, Joachim Prussner, Hensin Tsao, David Fisher

EXTREME RED-SHIFTED SERS ...... 27 Duncan Graham, Hayleigh Kearns, Matthew Bedics, Neil Shand, Michael Detty, Karen Faulds

SLIPSERS: WHEN A PITCHER PLANT MEETS WITH SERS ...... 28 Tak-Sing Wong, Shikuan Yang, Xianming Dai, Birgitt Boschitsch Stogin

STANDOFF SPATIAL HETERODYNE RAMAN SPECTROMETER FOR MINERALOGICAL ANALYSIS ...... 28 Miles Egan, Stanley Angel, Shiv Sharma

RAMAN MICROSCOPY

LIVE CELL IMAGING OF NANOPARTICLE TRAFFICKING: A SURFACE-ENHANCED RAMAN SCATTERING PERSPECTIVE ...... 29 Maria Navas-Moreno, Majid Mehrpouyen, Tatyana Chernenko, Demet Candas, Jian Jian Li, James W. Chan

HYPERSPECTRAL RAMAN MICROSCOPY ENABLES ROBUST AND FLEXIBLE MOLECULAR SENSING AND IMAGING ON NANOPOROUS GOLD NANOPARTICLES...... 29 Wei-Chuan Shih

HIGH-SPEED MULTICOLOR CHEMICAL IMAGING WITH STIMULATED RAMAN SCATTERING...... 30 Yasuyuki Ozeki

SURFACE-ENHANCED HYPER-RAMAN SCATTERING FROM OPTICALLY TRAPPED SILVER NANOPARTICLES ON YEAST...... 31 Yasutaka Kitahama, Hiroaki Hayashi, Tamitake Itoh, Yukihiro Ozaki

3D RAMAN IMAGING OF TRANSPARENT AND OPAQUE SAMPLES – APPLICATIONS IN PHARMACEUTICS -...... 31 Wei Liu, Andrea Richter, Thomas Dieing, Joachim Koenen, Ute Schmidt

TOPICS IN MICROSCOPY

NANOPARTICLE DIFFUSION ON SUB-MICROMETER OIL DROPLET-WATER INTERFACE STUDIED WITH THREE DIMENSIONAL SINGLE PARTICLE TRACKING...... 32 Gufeng Wang, Yaning Zhong

SCANNING ANGLE RAMAN SPECTROSCOPY MEASUREMENTS OF THIN POLYMER FILM THICKNESS, DOMAIN SIZE AND INDEX OF REFRACTION...... 33 Emily A Smith, Jonathan Bobbitt, Deyny Mendivelso

IN SITU RAMAN MAPPING OF MATERIALS UNDER MECHANICAL LOADING: SPATIAL VARIATION OF STRAIN EVOLUTION AND PHASE TRANSFORMATION ...... 34 Chris Michaels, Yvonne Gerbig, Robert Cook

QUANTITATIVE ANALYSIS OF POWDERED SOLIDS BY SECOND HARMONIC GENERATION MICROSCOPY ...... 34 Azhad Chowdhury, Shijie Zhang, Garth Simpson

PROBING THE MORPHOLOGY, NANOMECHANICS AND TRIBOLOGY OF BIOMEDICAL GELS WITH AFM ...... 35 Greg Haugstad, Joram Slager, Maggie Zeng, Alon McCormick, Bob Tranquillo, Anne Ellis

TOPICS IN SPECTROSCOPY

A SEARCH FOR THE (MOST) PERFECT SPECIATION METHOD OF ARSENIC IN RICE ...... 36 Patrick Gray

COMPUTATIONAL MODELING OF GC-VUV SPECTRA ...... 37 Jeremy Reyes, Bill Winniford, Eldad Herceg, Kefu Sun, Anna Sandlin, James Griffith, Chris Siegler, Phillip Walsh, Dale Harrison

TUNABLE LASER ABSORPTION SPECTROSCOPY IN FEMTOSECOND LASER ABLATION...... 38 Mark Phillips, Jeremy Yeak, Sivanandan Harilal

SPATIAL CHARACTERIZATIONS OF ALUMINUM LASER-INDUCED PLASMA ...... 38 David Surmick, Christian Parigger

SENSITIVITY OF IN VIVO RAMAN MEASUREMENTS TO PHYSIOLOGICAL VARIABILITY...... 39 Xiaohong Bi, Andrew W. Dupont, Shashideep Singhal, Larry D. Scott, Sushovan Guha, Mamoun Younes, Yuanqing Ye, Hao Ding

NEW DIRECTIONS IN NANOPLASMONICS

PLASMON-IN-A-BOX...... 40 Prashant Jain

MONITORING PLASMON RESONANCE SHIFTS UPON PLASMON EXCITATION WITH ULTRAFAST SURFACE-ENHANCED RAMAN SPECTROSCOPY...... 40 Emily Keller, Renee Frontiera

ACTIVE CONTROL OF NEAR-FIELD DISTRIBUTION IN PLASMONIC NANORODS ...... 41 Emilie Ringe, Sadegh Yazdi, Josee R. Daniel, Nicolas Large, George C. Schatz, Denis Boudreau

DETECTING NANOSCALE STRUCTURAL CHANGES WITH PLASMONICS: FROM SELF-ASSEMBLED PLASMON RULERS TO TUNABLE CIRCULAR DICHROISM ...... 41 Vivian Ferry

MOLECULAR STRUCTURE AND SOLVENT FACTORS INFLUENCING SERS ON PLANAR GOLD SUBSTRATES ...... 42 Ashish Tripathi, Erik D. Emmons, Jason A. Guicheteau, Augustus W. Fountain III, Steven D. Christesen

MONDAY POSTERS – ART & ARCHAEOLOGY

HANDHELD X-RAY FLUORESCENCE SPECTROMETRY FOR CHARACTERIZATION OF ARCHAEOLOGICAL MATERIALS FROM AN ETRUSCAN/ROMAN ARCHAEOLOGICAL SITE NEAR ORVIETO, ITALY...... 43 Kaliopi Konomi, Mary Kate Donais, David George

MICROCHEMICAL AND MICROSTRUCTURAL INVESTIGATION OF ISLAMIC GREEN AND MANGANESE GLAZED POTTERY FROM MERTOLA (PORTUGAL): PRELIMINARY RESULTS...... 44 Jose Mirao, Massimo Beltrame, Susana Gómez Martínez , Antonio Candeias

HERCULES LABORATORY: AN PORTUGUESE ANALYTICAL FACILITY FULLY COMMITTED TO THE MATERIAL STUDY OF CULTURAL HERITAGE ...... 44 Jose Mirao, Antonio Candeias, Cristina Dias, Ana Teresa Caldeira

MONDAY POSTERS – BIOMEDICAL AND BIOANALYTICA SCIENCES – SESSION I

SEPSIS: SERUM SPECTROSCOPIC SENSING...... 45 Matthew Baker, Lila Lovergne, Ganesh Sockalingum, Valerie Untereiner, Roman Lukaszewski

TUNABLE LUMINESCENT CARBON NANOSPHERES WITH WELL-DEFINED NANOSCALE CHEMISTRY FOR SYNCHRONIZED IMAGING AND THERAPY ...... 46 Prabuddha Mukherjee, Santosh Misra, William Wilson, John Scott, Dipanjan Pan, Rohit Bhargava

SYNERGY OF COLD ATMOSPHERIC PLASMA AND ELECTROPORATION FOR TREATMENT OF CANCER CELLS...... 46 Arianna Avellan, Rohil Jain, Prasoon Diwakar, Cagri Savran, Ahmed Hassanein

EARLY PREDICTION OF RENAL GRAFT OUTCOMES BY INTERROGATION OF FIBROTIC REGIONS...... 47 Vishal Varma, Andre Kajdacsy-Balla , Sanjeev Akkina, Suman Setty, Michael Walsh

KIDNEY STONE ANALYSIS UTILIZING FOURIER TRANSFORM INFRARED SPECTROSCOPY...... 48 Olivia Maleki

COMPARISON OF MULTIVARIATE ANALYSIS TECHNIQUES FOR INVESTIGATING PARAFFIN- EMBEDDED CANCER TISSUE SECTION USING RAMAN IMAGING SYSTEM ...... 49 Phiranuphon Meksiarun, Ishigaki Mika, Verena A. C. Huck-Pezzei, Christian W. Huck, Hidetoshi Sato, Yukihiro Ozaki

MONDAY POSTERS – FORENSICS & SECURITY

SUBLIMATION DYNAMICS OF EXPLOSIVES PARTICLES UNDER VARIOUS ENVIRONMENTAL CONDITIONS ...... 49 Michael Papantonakis, Robert Furstenberg, Viet Nguyen, Thomas Fischer, Christopher Kendziora, Andrew McGill

MECHANISTIC STUDIES OF PARTICLE DEPOSITIONS IN A FINGERPRINT...... 50 Michael Papantonakis, Viet Nguyen, Robert Furstenberg, Thomas Fischer, Lily Zehfus, Christine Mahoney, Andrew McGill

DHS CHEMICAL FORENSICS PROGRAM – REACTS...... 51 Evan Durnal, Krista Brady, Keith Broekhuizen, Peter Deardorff

IDENTIFICATION OF INDIVIDUAL RED BLOOD CELLS BY RAMAN MICROSPECTROSCOPY FOR FORENSIC PURPOSES ...... 51 Claire Muro, Igor Lednev

USE OF FIB/SEM FOR SPATIALLY RESOLVED MASS SPECTROMETRY MEASUREMENTS ...... 52 Dallas Reilly, Edgar Buck

IDENTIFICATION OF PEN INKS USING GRATING-BASED SPECTRAL IMAGING MICROSCOPY AND ELECTROSPRAY IONIZATION MASS SPECTROMETRY...... 52 Emily Horton, Michael R. Webb

DART-MS IMAGING OF ADULTERATED BREAD TO SUGGEST ROUTE OF CONTAMINATION...... 53 Travis Falconer

DETECTION OF EXPLOSIVES FROM SURFACE SWABS USING THERMAL DESORPTION DART-MS AND REVERSE LIBRARY SEARCH ...... 53 Frederick Li, Joseph Tice, Steve Shrader, Paul Liang, Brian Musselman

ANALYSIS OF IED WIRES BY ISOTOPE RATIO MASS SPECTROMETRY ...... 54 Jane Vezina, Douglas Beussman

ISOTOPE RATIO MASS SPECTROMETRY ANALYSIS OF NATURAL AND SYNTHETIC FIBERS AND EFFECTS OF CHEMICAL AND ENVIRONMENTAL FACTORS FOR FORENSIC APPLICATIONS ...... 54 Hannah Brown, Dat Le, Douglas Beussman

MONDAY POSTERS – MOLECULAR/IR

CONFORMATIONAL STABILITY AND ENTHALPY DIFFERENCE OF SOME SILANE AND CYCLOPENTANE COMPOUNDS ...... 55 Dattatray Sawant

INFRARED ANALYSIS OF OIL IN WATER: TRADITIONAL LIQUID CELLS VERSUS UNIQUELY DESIGNED MORE USER FRIENDLY DIALPATH TRANSMISSION CELLS ...... 56 Dipak Mainali, Frank Higgins

HIGH RESOLUTION, HIGH SENSITIVITY FT-IR FOR INDUSTRIAL ANALYSIS OF GAS PHASE SAMPLES ...... 56 Steve Lowry, Jay Roberts, Frank Wasacz, Karnel Walker

THE POTENTIAL OF FTIR SPECTROSCOPY AND COMPUTATIONAL ANALYSIS IN CHARACTERIZING THE MECHANISM OF ACTION OF BLUE-LIGHT AGAINST METHICILLIN- RESISTANT STAPHYLOCOCCUS AUREUS...... 57 Ebrahim Aboualizadeh, Violet Bumah, Daniela Masson-Meyers, Janis Eells, Chukuka Enwemeka, Carol Hirschmugl

ACCURATE DIAGNOSIS OF THYROID CARCINOMA SUBTYPES: ADDRESSING TISSUE HETEROGENEITY IN INFRARED SPECTROSCOPIC IMAGING ...... 58 David Martinez Marin, Hari Sreedhar, Vishal Varma, Catarina Eloy, Manuel Sobrinho-Simões, André Kajdacsy-Ballaa, Michael Walsh

STUDY ON THE MOLECULAR INTERACTION OF HYDRATION WATER WITH THE SULFONIC ACID GROUP INVOLVED IN NAFION...... 59 Takafumi Shimoaka, Chihiro Wakai, Takeshi Hasegawa

STRATEGY FOR CREATING 3-AMINOPROPYLTRIETHOXYSILANE-DERIVED MICROARRAYS ON POROUS SILICON...... 60 Sidney Coombs, Frank Bright

DIGITAL CONFOCAL FTIR MICROSCOPY ...... 60 Alex Schofield, Carol Hirschmugl

INVESTIGATING THE HEAVY ATOM EFFECT IN TRIPHENYL METAL HYDRIDES VIA IR PUMP- PROBE AND 2D-IR SPECTROSCOPIES...... 61 Cynthia Pyles, Courtney Olson, Ivan Spector, Aaron Massari

MID-IR SPECTRAL HISTOPATHOLOGY: CLASSIFICATION OF BIOMEDICAL IMAGES WITH SPECTRAL MARKERS SELECTED BY GA-FDA ...... 61 Rupali Mankar, Vishal Varma, Michael Walsh, Carlos Bueso-Ramos, David Mayerich

MONDAY POSTERS – ITP – ELECTROSEPARATION METHODS

DIRECT ANALYSIS OF IONOGENIC SUBSTANCES IN THERMOREVERSIBLE GEL SAMPLES BY CAPILLARY ISOTACHOPHORESIS ...... 62 Róbert Bodor, Marian Koval, Marián Masár

MEASURING EXTRACELLULAR AMINO ACID DYNAMICS FROM 3T3-L1 ADIPOCYTES USING ONLINE MICRODIALYSIS-CAPILLARY ELECTROPHORESIS ...... 63 Rachel Harstad, Michael Bowser

CAPILLARY ELECTROPHORESIS COUPLED WITH MICRO FREE FLOW ELECTROPHORESIS FOR HIGH SPEED COMPREHENSIVE TWO DIMENSIONAL ANALYSIS OF PEPTIDES ...... 64 Alexander Johnson, Michael Bowser

ELECTROEXTRACTION COUPLED ON-LINE TO CAPILLARY ELECTROPHORESIS – MASS SPECTROMETRY: AN INNOVATIVE TOOL FOR METABOLOMIC PROFILING OF BIOMASS-LIMITED SAMPLES ...... 64 Amar Oedit, Thomas Hankemeier, Peter Lindenburg

MECHANISM OF SEQUENCE-BASED SEPARATION OF SINGLE-STRANDED DNA IN CAPILLARY ZONE ELECTROPHORESIS ...... 65 Jia Zhao, Steven Cramer, Linda McGown

INCREASING THE SEPARATION CAPABILITY OF INSULATOR-BASED DIELECTROPHORESIS ...... 66 Claire Crowther, Mark Hayes

DIELECTROPHORETIC DIFFERENTIATION AND SEPARATION BASED ON ANTIBIOTIC RESISTANCE ...... 67 Shannon Huey Hilton, Mark A. Hayes

DESIGN OF EXPERIMENTS FOR AMINO ACID EXTRACTION FROM NICOTIANA TABACUM AND THEIR SUBSEQUENT DETERMINATION BY CAPILLARY ZONE ELECTROPHORESIS ...... 67 Ondrej Hodek, Tomáš Krížek

AN INFLUENCE OF VARIOUS OPERATIONAL CONDITIONS ON OFFGEL ISOELECTRIC FOCUSING ...... 68 Magda Ördögová

GLYCOFORM ANALYSIS OF ALPHA1-ACID GLYCOPROTEIN BY CAPILLARY ELECTROPHORESIS WITH ELECTROOSMOTIC FLOW ABSENT FIELD ENHANCED SAMPLE INJECTION ...... 69 Chenhua Zhang, Cong Bi, William Clarke, David Hage

INTERACTIONS OF HELQUATS WITH CHIRAL ACIDIC AROMATIC ANALYTES STUDIED BY PARTIAL-FILLING AFFINITY CAPILLARY ELECTROPHORESIS ...... 70 Vaclav Kasicka, Martin Ruzicka, Dusan Koval, Jan Vavra, Paul Reyes-Gutierrez, Filip Teply

DEVELOPMENT OF CAPILLARY SEPARATION SYSTEM FOR COMPLEX CHARACTERIZATION OF GLYCOMIC SAMPLES ...... 71 Jana Vanova, Petr Cesla, Vaclav Simanek, Jana Krenkova, Jan Fischer

SOLVING COMPLEX-FORMING EQUILIBRIA IN CAPILLARY ELECTROMIGRATION THEORY...... 71 Michal Malý, Magda Ördögová, Pavel Dubský

PARTICLE-PARTICLE INTERACTIONS IN INSULATOR BASED DIELECTROPHORESIS ...... 72 Mario Saucedo-Espinosa, Blanca Lapizco-Encinas

CAPILLARY ELECTROPHORETIC DETERMINATION OF CEFTAZIDIME IN HUMAN BLOOD AND MICRODIALYSATES FROM DIABETIC FOOT AFTER ACETONITRILE-BASED SAMPLE STACKING ...... 73 Petr Tuma, Martin Jacek, Vladimira Fejfarova, Jan Polak

HEADSPACE IN-TUBE MICROEXTRACTION COUPLED WITH MICELLAR ELECTROKINETIC CHROMATOGRAPHY OF NEUTRAL AROMATIC COMPOUNDS ...... 73 Yoon Jeong Choi, Sung Min Cho, Bum Su Park, Woo Sung Jung, Sang Won Lee, Yunhwan Jung

ASSESSMENT OF COMPLEX BIOLOGICAL SAMPLES WITH INSULATOR-BASED DIELECTROPHORESIS...... 74 Maria F. Romero-Creel, Alexandra Lalonde, Blanca H. Lapizco-Encinas

JOULE HEATING EFFECTS IN DIELECTROPHORETIC DEVICES OF OPTIMIZED POSTS GEOMETRY ...... 74 Laura M. Arciniegas, Victor H. Pérez-González, Roberto C. Gallo-Villanueva, Blanca H. Lapizco-Encinas

A NOVEL IMAGE ANALYSIS BASED CAPILLARY ELECTROPHORESIS DETECTION SYSTEM...... 75 Andras Guttman, Marton Szigeti, Mate Szarka

MONDAY POSTERS – MASS SPECTROMETRY

SIMULATION OF A HELIUM DC GLOW DISCHARGE USED AS AN AMBIENT DESORPTION/IONIZATION SOURCE FOR MASS SPECTROMETRY...... 76 Wade C Ellis, Ross L Spencer, Paul B Farnsworth

MODELING GAS-SKIMMER CONE INTERACTIONS IN THE ICP-MS USING DSMC...... 76 Ross Spencer, Michael Carlson

STABILITY AND PRECISION OF A LIQUID SAMPLING - ATMOSPHERIC PRESSURE GLOW DISCHARGE ION SOURCE INTERFACED WITH A ORBITRAP MASS ANALYZER ...... 77 Edward Hoegg, Garret Hart, George Hager, David Koppenaal, Kenneth Marcus

DETERMINATION OF SEMET BY HPLC- MP-AES WITH POST-COLUMN HYDRIDE GENERATION...... 77 Eunice Yañez Barrientos, Kazimierz Wrobel, Alma Rosa Corrales Escobosa, Francisco Acevedo Aguilar, Katarzyna Wrobel

HPLC-QTOF ANALYSIS FOR SCREENING AND QUANTIFICATION OF DRUGS OF ABUSE USING DIAGNOSTIC IONS FOR ANALYTES AND INTERNAL STANDARDS ...... 78 McCauley Reardon, Aditya Kulkarni, Matt Willetts, Howard Taylor, Shannon Johnson, Stephanie Whitson

CORRECTING SATURATION IN MASS SPECTROMETRY DATA USING PRINCIPAL COMPONENTS ANALYSIS...... 79 Stephanie Dejong, James Hochrein, Lance Miller, Mark Van Benthem

INVESTIGATING THE POTENTIAL OF TRANSITION METAL CATIONS TO PROBE THE GAS PHASE STRUCTURES OF ISOMERIC CARBOHYDRATES...... 79 Yuting Huang, Lauren M. Petrosh, Katherine N. Schumacher, Eric D. Dodds

SPECTRAL COMPARISON OF DIELECTRIC BARRIER DISCHARGE IONIZATION SOURCES ...... 80 Daniel F. Thurston, David Klute, Joachim Franzke, Paul B. Farnsworth

IMPROVED INSTRUMENT ROBUSTNESS VIA A HOT SOURCE INDUCED DESOLVATION (HSID) INTERFACE FOR TANDEM MASS SPECTROMETRY INSTRUMENTATION ...... 81 Frank Kero

DESORPTION/IONIZATION SYSTEM FOR SKIN-SURFACE COMPOUNDS MAPPING USING LOW POWER LASER AND NON-THERMAL PLASMA...... 81 Mari Aida, Yuya Yamashita, Ken Kakegawa, Hidekazu Miyahara, Akitoshi Okino

MWCNT FUNCTIONALIZED APCI CORONA PIN FOR PAH SAMPLING ...... 82 Keaton Nahan, Vesselin Shanov, Anne Vonderheide

MONDAY POSTERS – RAMAN SERS

DIVERSE SERS SUBSTRATES NANOFABRICATED ON-DEMAND BY ELECTROLESS PLATING ...... 83 Jason Dwyer

A STABLE, DISPOSABLE, HOMOGENEOUS NANOSTRUCTURED SUBSTRATE FOR SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) DETECTION OF VARIOUS ANALYTE MOLECULES ...... 83 Honey Madupalli, Mary Tecklenburg

LONG TERM STABILITY OF GOLD AND SILVER NANOPARTICLE ACTIVITY IN POLYMER FILMS FOR SERS APPLICATIONS ...... 84 Mary Tecklenburg, Honey Madupalli, Md. Shah Alam

QUANTITATIVE ONLINE SHEATH-FLOW SURFACE ENHANCED RAMAN SPECTROSCOPY DETECTION FOR LIQUID CHROMATOGRAPHY...... 85 Anh Nguyen, Zachary D. Schultz

EXPLORING THE EFFECT OF INTERMOLECULAR H-BOND AND THE APPLICATION IN ENATIOSELECTIVE DISCRIMINATION BY SERS...... 85 Bing Zhao, Yue Wang, Yukihiro Ozaki

APPLICATION OF THE SUPERHYDROPHOBIC BIOMIMETIC CHIP IN SERS ANALYSIS ...... 86 Qian Cong, Zhi Yu, Young Mee Jung

LABEL-FREE PROTEIN DETECTION ON SILVER NANODOMES USING SURFACE-ENHANCED RAMAN SCATTERING...... 86 Aysun Korkmaz, Handan Yuksel, Ramazan Solmaz, Adile Gürkan, Mehmet Kahraman

MULTIPLEX DNA ANALYSIS USING SURFACE-ENHANCED RAMAN SCATTERING ...... 87 Tugce Yigit, Ebru Akdogan, Isik Didem Karagoz, Mehmet Kahraman

DETECTION OF BACTERIA USING SERS-BASED IMMUNOASSAY...... 87 Gamze Yaman, Okkes Celik, Nese Erdogan, Ibrahim Halil Kilic, Dilek Buyukbese, Mehmet Kahraman

ENHANCING RAMAN SIGNALING UNDER HIGH PRESSURE ...... 88 Abdullah Al Balushi, Kirsten Gracie, Duncan Graham, Alexander Mullen, Iain Oswald

REPRODUCIBILITY AND STABILITY OF SERS SIGNAL OF ANALYTES ON A PEI POLYMER MATRIX EMBEDDED WITH GOLD NANOPARTICLES...... 88 Md Shah Alam, Mary M. J. Tecklenburg

FILTER BASED SURFACE-ENHANCED RAMAN SCATTERING (SERS) SUBSTRATES FOR AQUEOUS ENVIRONMENTAL ANALYTE DETECTION...... 89 Kyle Bantz, Garrett Briggs, Michael Parsons

3-DIMENSIONAL SERS IMAGING USING HIGHLY SYMMETRIC SILVER MICROPARTICLES WITH NANOPORES AS A SUBSTRATE...... 90 Sanpon Vantasin, Wei Ji, Yoshito Tanaka, Yasutaka Kitahama, Kanet Wongravee, Harnchana Gatemala, Sanong Ekgasit, Yukihiro Ozaki

A GOLD NANOHOLE ARRAY BASED BIOSENSOR FOR MERCURY DETECTION IN HUMAN SALIVA...... 91 Peng Zheng, Nianqiang Wu

MONDAY POSTERS – DEEP AND FAR UV SPECTROSCOPY

FIRST ELECTRONIC TRANSITION OF INTERFACIAL WATER ADSORBED ON ALUMINA SURFACE STUDIED BY FAR-ULTRAVIOLET SPECTROSCOPY...... 91 Takeyoshi Goto, Yukihiro Ozaki

CATION SIZE EFFECTS ON A?X TRANSITION OF PROTON-WATER CLUSTER: ELECTRONIC DELOCALIZATION OF HYDRATED PROTON IN LIQUID WATER ...... 92 Takeyoshi Goto, Krzysztof Bec, Yukihiro Ozaki

ELECTRONIC STATES OF COMPOSITE POLYMER ELECTROLYTE COMPOSED OF PEG AND LITHIUM-SALTS...... 93 Nami Ueno, Tomonari Wakabayashi, Yusuke Morisawa

THE ELECTORONIC STATES OF COMPOSITE POLYMER ELRCTROLYTES COMPOSED OF POLY(ETHYLENE GLYCOL) AND LITHIUM SALT...... 94 Nami Ueno, Tomonari Wakabayashi, Yusuke Moriswa

MONDAY POSTERS – XRAY FLUORESCENCE

USE OF SYNCHROTRON X-RAY FLUORESCENCE MICROPROBE TO THE STUDY OF INKS AND THEIR SEPARATION USING PAPER CHROMATOGRAPHY ...... 94 Dale L Perry, Tom J Wilkinson, Albert C Thompson

X-RAY BASED ANALYTICAL METHODS AND THE COLOR OF MARBLES AND LIMESTONES USED IN ARCHITECTURE ...... 95 Jose Mirao, Luis Dias, Pedro Barrulas, Luis Lopes, Patricia Moita, Ana Teresa Caldeira, Antonio Candeias

NOVEL APPLICATIONS OF LASER ABLATION – ICPMS AND RELATED TECHNIQUES

DETECTION OF ENGINEERED NANOPARTICLES IN WATER, SOIL AND SEDIMENTS: FROM BULK ANALYSIS TO SINGLE PARTICLE ICP-TOF-MS...... 96 Frank Von Der Kammer, Antonia Praetorius, Andreas Gondikas, Jana Navratilova, Olga Borovinskaya, Alexander Gundlach- Graham, Detlev Gunther, Thilo Hofmann

NOVEL “FILTER PELLET” SAMPLE PREPARATION STRATEGY FOR ANALYSIS OF FILTER-BOUND SEDIMENT SAMPLES BY LASER ABLATION ICP-MS- APPLICATION TO SEDIMENT FINGERPRINTING...... 96 Ruthmara Corzo, Sarah Jantzi, Christopher Dutton, Amartya Saha, Jose Almirall

BIOIMAGING OF METALS AND BIOMOLECULES IN BREAST TISSUES BY LA-MS ...... 97 Raquel Gonzalez De Vega, Maria Luisa Fernández Sánchez, Jorge Pisonero, Noemí Eiró, Francisco J. Vizoso, Uwe Karst, Alfredo Sanz-Medel

CLIMATE VARIABILITY IN THE NORTHWEST IBERIAN PENINSULA DURING THE LAST MILLENNIUM BASED ON LA-ICP-MS ANALYSIS OF SPELEOTHEMS RECORDS...... 98 Miguel Iglesias, Jorge Pisonero, Wolfgang Muller, Hai Cheng, R. Lawrence Edwards, Heather Stoll

BIO-IMAGING BY LA-ICP-MS: QUANTIFICATION AND UNCERTAINTY ESTIMATION...... 99 David Douglas, Jennifer O’Reilly, Heidi Goenaga-Infante

RSC AWARDS SYMPOSIUM

QUANTIFICATION OF THE COMPOSITION, VOLATILITY, AND SOURCES OF PARTICULATE MATTER BY FIELD-DEPLOYABLE MASS SPECTROMETRY: IMPLICATIONS FOR AIR QUALITY AND HEALTH ...... 100 Patrick Hayes

SINGLE PARTICLE MASS SPECTROMETRIC STUDIES OF CARBONACEOUS AEROSOL ...... 101 Jonathan Abbatt

LIFE, DEATH AND SERS...... 101 Colin Campbell, Lauren Jamieson, Victoria Camus, Hannah Johnston, William Nailon, Duncan McLaren, David Harrison

BIOSENSING USING SERS ...... 101 Karen Faulds

YET ANOTHER SERS TALK!...... 102 Duncan Graham

CLIRSPEC: BIOLOGICAL FLUIDS IN HEALTH AND DISEASE

TOWARDS NON-INVASIVE SPECTROSCOPY OF RED BLOOD CELLS STORED IN TRANSFUSION BAGS...... 102 Michael Blades, Kevin Buckley, Robin F. B. Turner , H. G. Schulze, Deborah Chen, Dana Devine

LIPIDS OR BASIC CALCIUM PHOSPHATES: A NOVEL FAMILY OF SYNOVIAL FLUID CRYSTALS IDENTIFIED BY RAMAN SPECTROSCOPY...... 103 Ozan Akkus, Bolan Li, Nora Singer

DEVELOPMENT AND ANALYSIS OF LIQUID, LIQUID SERUM BIOPSIES ...... 104 Katie Spalding, Ruth Board, Benjamin Bird, Caryn Hughes, Matthew James Baker

SERS-BASED IN VITRO ASSAYS FOR THE SENSITIVE DETECTION OF CARDIOVASCULAR DISEASE BIOMARKERS IN CLINICAL SAMPLES...... 105 Lee Barrett, Naveed Sattar, Karen Faulds, Duncan Graham

QUANTITATIVE RAMAN SPECTROSCOPY FOR PROTEIN THERAPEUTICS...... 105 William Herrington, Gajendra Singh, Di Wu, Paul Barone, William Hancock, Rajeev Ram

NEW FRONTIERS IN CHEMOMETRICS

DATA PREPROCESSING- THE MAIN BOTTLENECK IN DATA ANALYSIS...... 106 Beata Walczak

SINGLE BACTERIA IDENTIFICATION BY RAMAN SPECTROSCOPY AND TOPOLOGICAL DATA ANALYSIS...... 106 Ludovic Duponchel

ILS TO CLS: SYNERGISTIC REGRESSION MODELING FOR IMPROVED CONTROL AND INTERPRETABILITY...... 107 Neal Gallagher

WHOLE SPECTRUM UNMIXING FOR RAMAN AND FTIR APPLICATIONS ...... 107 Cj Carey, M. Darby Dyar

PARAMETER-FREE SUPPORT VECTOR MACHINES FOR CALIBRATION WITH HYBRID PENALTY FUNCTION...... 108 Peter Harrington

NANOSCALE IR SPECTROSCOPY

APPLICATIONS OF NANOSCALE CHEMICAL IMAGING TO POLYMERIC SYSTEMS ...... 109 Mark Rickard, Gregory Meyers, Carl Reinhardt, Jamie Stanley

NANOSCALE CHARACTERIZATION OF ENGINEERED THERMOPLASTIC MATERIALS BY ATOMIC FORCE MICROSCOPY – INFRARED SPECTROSCOPY (AFM-IR) IN COMBINATION WITH TRADITIONAL MICROSCOPY AND SPECTROSCOPY METHODS ...... 110 Anne Lemon, Liang Gong, Lanti Yang, Pooja Bajaj, John Rabolt, Bruce Chase

AFM-IR STUDIES OF COLLAGEN MICROSTRUCTURE AND CHEMICAL COMPOSITION FOR ESTROGEN DEPLETED AND DRUG TREATED CORTICAL BONE AND LUMBAR VERTEBRAE...... 110 Mark Banaszak Holl, Meagan Cauble, Matthew Muckley, Taeyong Ahn, Sriram Vaidyanathan, Rachel Merzel, Jeffrey Fessler, Bradford Orr, Le Duong

AFM-IR OF A NANOSTRUCTURED BIOADHESIVE PRODUCED BY ACORN BARNACLES ...... 111 Daniel Barlow, Kenan Fears, Christopher So, Jenifer Scancella, Kedar Manandhar, Boris Feygelson, Beatriz Orihuela, Daniel Rittschof, Kathryn Wahl

NANOSCALE INVESTIGATION OF NANOSCALE STRUCTURE TRANSITIONS IN SILK PROTEINS USING NEAR-FIELD OPTICS ...... 112 Shaoqing Zhang, Woonsoo Lee

FUNDAMENTALS OF ELECTROPHORESIS

CAPILLARY ELECTROPHORESIS AND DENSITY FUNCTIONAL THEORY EMPLOYED FOR CHARACTERIZATION OF BIOPEPTIDE COMPLEXES WITH AMMONIUM AND ALKALI METAL IONS...... 113 Vaclav Kasicka, Sachinkumar Pangavhane, Stanislav Boehm, Emanuel Makrlik, Paolo Ruzza

THE RELATIONSHIP BETWEEN ELECTROPHORETIC MOBILITY AND POLYION CHARGE...... 114 Nancy Stellwagen

THE DYNAMICS OF COMIGRATION: AN INSIGHT INTO A CLUSTER OF TWO SEMI-SEPARATED PEAKS...... 114 Pavel Dubský, Martin Dvorák

EXPLORING THE PROMISE OF MICROGRADIENT ELECTROPHORETIC SEPARATIONS...... 115 Mark Hayes, Fanyi Zhu, Michael Keebaugh

SIZE AND CHARGE CHARACTERIZATION OF NANOMOLECULAR ENTITIES BY TAYLOR DISPERSION ANALYSIS AND CAPILLARY ELECTROPHORESIS ...... 116 Hervé Cottet, Joseph Chamieh, Laurent Leclercq, Michel Martin, Luca Cipelletti

BIOMEDICAL AND BIOANALYSIS

STUDY ON THE PROTEIN–PROTEIN INTERACTION IN SINGLE LIVING CELLS BY MICROFLUIDIC CHIP WITH SINGLE MOLECULE FLUORESCENCE CORRELATION SPECTROSCOPY ...... 116 Jicun Ren, Chaoqing Dong

QUANTITATIVE METHOD DEVELOPMENT FOR THE SIMULTANEOUS DETERMINATION OF TOCOPHEROLS AND TOCOTRIENOLS IN HUMAN ADIPOSE TISSUE AND SERUM...... 117 Danuta Siluk, Ewa Bartosinska, Magdalena Buszewska-Forajta, Wiktoria Struck-Lewicka , Julia Jacyna, Agnieszka Borsuk, Pawel Wiczling , Roman Kaliszan

INSIGHTS INTO PROTEIN TYROSINE NITRATION IN BRAIN CANCERS...... 118 Xianquan Zhan

ELECTROPHYSIOLOGICAL RHYTHMS IN BLOOD ...... 119 Fatima Labeed, Erin Henslee, Malcolm Von Schantz, Rita Jabr, Akhilesh Reddy, John O’Neill, Daan Van Der Veen, Rula Abdallat

LOW-COPY NUMBER BIOMOLECULAR ANALYSIS WITH DIELECTROPHORETIC ENRICHMENT /TRAPPING VIA MOLECULAR DAM AND PLASMONIC ELECTRODE NANOGAPS...... 120 Chia-Fu Chou

TUNING SOFT IONIZATION STRENGTH FOR ORGANIC MASS SPECTROMETRY...... 120 Alexander Schütz, Sebastian Brandt Brandt, Felix David Klute, Joachim Franzke

3D PRINTING: INTERMEDIATE FAST PROTOTYPING AND ENLARGING POSSIBILITIES FOR ANALYTICAL SCIENCES ...... 121 Sebastian Brandt, Alexander Schütz, Felix David Klute, Joachim Franzke

HIGH-RESOLUTION ATMOSPHERIC PRESSURE DRIFT TUBE ION MOBILITY SPECTROMETRY COUPLED WITH ULTRA-ACCURATE MASS ORBITRAP MASS SPECTROMETRY...... 122 Stephen Zambrzycki, Anyin Li, Joel Keelor, Brian Clowers, Facundo Fernandez

A NOVEL GAS CHROMATOGRAPHY MASS SPECTROMETRY APPROACH FOR THE DETERMINATION OF INORGANIC ANIONS ...... 123 Enea Pagliano, Beatrice Campanella, Massimo Onor, Emilia Bramanti, Alessandro D, Zoltan Mester

SINGLE PARTICLE INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY FOR NANOPARTICLE CHARACTERIZATION: CALIBRATION TECHNIQUES AND FUNDAMENTAL PROCESSES THAT GENERATE SIGNALS FROM SOLUTIONS VS. NANOPARTICLES...... 123 John Olesik, Austin Wilson

NANO-FACILITATED SENSING

CHANGING PLASMONIC NANOPARTICLE SHAPE AND RESONANCE FREQUENCY VIA MECHANICAL DEFORMATION ...... 124 Jeffrey Anker

SINGLE NANOPARTICLE PLASMONIC SPECTROSCOPY FOR SINGLE-MOLECULE SENSING AND SUPER-RESOLUTION IMAGING OF SINGLE LIVE CELLS...... 124 X. Nancy Xu, Pavan K. Cherukuri, Kerry J. Lee, Tao Huang, Feng Ding

ULTRASENSITIVE DETECTION WITH SEHRS: FROM SINGLE MOLECULES TO NIR IMAGING...... 125 Jon Camden

PLASMON-DRIVEN PHOTOCATALYTIC MOLECULAR TRANSFORMATIONS: A PLASMON- ENHANCED SPECTROSCOPIC STUDY ...... 125 Hui Wang

WETTING EFFECTS ON SURFACE ENHANCED SIGNALS FROM GOLD COATED NANOPILLAR SUBSTRATES ...... 126 David E. Thompson, Manpinder Kaur, Alam Nure, Alyssa Noonan, Xinmei Dong

COUNTERFEIT CHALLENGES IN BIOPHARMACEUTICALS

PHARMACEUTICAL EVALUATION OF ATORVASTATIN CALCIUM TABLETS AVAILABLE ON THE INTERNET ...... 127 Toshiro Fukami, Motoki Inoue, Hiroshi Hisada, Tatsuo Koide

COMBATING COUNTERFEIT MEDICINES: THE USE OF NMR AND MS TECHNIQUES...... 127 Ian Jones

ASSESSMENT OF THE EFFECTIVENESS OF THE CD3+ TOOL TO DETECT COUNTERFEIT AND SUBSTANDARD ANTI-MALARIALS...... 128 Mustapha Hajjou

COMPLEMENTARITY OF PDA AND MS DETECTION FOR CHROMATOGRAPHIC FINGERPRINTING OF GENUINE AND COUNTERFEIT VIAGRA® ...... 128 Deborah Custers, Barbara Krakowska, Patricia Courselle, Michal Daszykowski, Sandra Apers, Eric Deconinck

BIOANALYTICAL SERS I

MHRA SAMPLING PROGRAMME AND CHOICE OF TARGET PRODUCTS...... 129 Stephen Young

DEVELOPMENT OF ALUMINUM SUBSTRATES FOR UV SURFACE-ENHANCED RESONANCE RAMAN SPECTROSCOPY...... 129 Bhavya Sharma

OPTIMISATION OF SURFACE ENHANCED RAMAN SCATTERING AND ISOTOPIC LABELLING FOR UNAMBIGUOUS BACTERIAL IDENTIFICATION...... 130 Howbeer Muhamadali, Abdu Subaihi, Yun Xu, David Ellis, Royston Goodacre

RAPID DETECTION AND IDENTIFICATION OF BACTERIAL MENINGITIS PATHOGENS IN EX VIVO CLINICAL SAMPLES BY SERS METHOD AND PRINCIPAL COMPONENT ANALYSIS...... 131 Agnieszka Kaminska

SINGLE-BACTERIA ANALYSIS BY SURFACE ENHANCED RAMAN SPECTROSCOPY SERS...... 131 Christoph Haisch, Haibo Zhou, Nicoleta Mircescu, Natalie Ivleva, Reinhard Niessner, Andreas Wieser

IMPROVED LATERAL FLOW SERS IMMUNOASSAY PERFORMANCE USING A NEW APPROACH TO ANTIBODY CONJUGATION OF GOLD NANOPARTICLES...... 132 Pietro Gancitano, Stephen Carmichael, Karen Faulds, Duncan Graham

PORTABLE RAMAN

PORTABLE RAMAN: THEN, NOW, AND BEYOND...... 133 Keith Carron

APPLICATIONS OF PORTABLE AND HANDHELD RAMAN SYSTEMS TO MILITARY DETECTION SCENARIOS...... 133 Jason Guicheteau, Steven Christesen, Ashish Tripathi, Erik Emmons, Phillip Wilcox, Augustus W. Fountain III

IMPLEMENTATION OF A CELL PHONE CAMERA AS A DETECTOR FOR A MINIATURE SPATIAL HETERODYNE RAMAN SPECTROMETER ...... 134 Patrick D. Barnett, S. Michael Angel

COMPLEX MIXTURE ANALYSIS USING HAND-HELD RAMAN CHEMICAL DETECTORS AND NOVEL SPECTRAL DECONVOLUTION ALGORITHMS...... 134 Rhea Clewes, Mehrdad Yaghoobi, Di Wu, Mike Davies

TIME-GATED RAMAN SPECTROSCOPY USING SPAD MATRIX DETECTORS: TOWARDS HAND-HELD SCALE...... 135 Lauri Kurki, Jouni Takalo, Mari Tenhunen, Jussi Tenhunen

NEW DIRECTIONS IN PLASMNIC APPLICATIONS AND INSTRUMENTATION

APPLICATIONS OF SERS PH NANOPROBES PRODUCED BY CO-SOLVENT CONTROLLED AUNP AGGREGATION ...... 135 Peter Vikesland, Haoran Wei, Marjorie Willner, Linsey Marr

SINGLE NANOPARTICLE SPR IMAGING MICROSCOPY OF BIOAFFINITY, UPTAKE AND SURFACE ENZYMATIC REACTIONS ...... 136 Adam Maley, Robert M. Corn

CELL IMAGING WITH METAL CLAD WAVEGUIDE (MCWG) MICROSCOPY ...... 137 Paul G. Charette, Thomas Söllradl, Frédéric A. Banville, Ulrike Fröhlich, Vincent Chabot, Pierre-Jean Zermatten, Michael T. Canva, Michel Grandbois

CHARACTERIZATION AND APPLICATIONS OF NANOPOROUS GOLD NANOPARTICLES IN THE NEAR-INFRARED ...... 137 Wei-Chuan Shih

INSIGHT INTO PLASMON-DRIVEN PHOTOCHEMISTRY VIA SURFACE-ENHANCED RAMAN SPECTROSCOPY...... 138 James Brooks, Renee Frontiera

RSC-ACS SYMPOSIUM – SOLVING GLOBAL HEALTH CHALLENGES: ELEMENTAL TECHNIQUES TOWARDS CHARACTERIZATION, DIAGNOSTICS, AND DETECTION

ARSENIC-RELATED HEALTH CHALLENGES: MAKING STUDENTS AWARE AND GETTING THEM INVOLVED...... 138 Julian Tyson, Ray Kronquist

LAB ON PAPER FOR QUANTIFICATION OF ANALYTES AT PPM AND PPB LEVELS ...... 139 Marya Lieberman, Nicholas Myers

ELECTROCHEMICALLY MODULATED SEPARATION FOR IODINE AND CESIUM FOR DETECTION AND DIAGNOSIS...... 140 Sandra Pratt, Douglas Duckworth, Shane Peper, Kate Magee, Katy Fordyce, Janet Cloutier

IMAGING IRON: THE KEY TO UNDERSTANDING AGING AND NEURODEGENERATION? ...... 141 Dominic Hare, Philip Doble

ELEMENTAL SPECIATION OF ENVIRONMENTAL AND BIOLOGICAL MATERIALS USING ULTRA- HIGH RESOLUTION MASS SPECTROMETRY ...... 141 David Koppenaal, Walker Larry, Tfaily Malak, Jared Shaw, Nancy Hess, Pasa-Tolic Lilijana

INNOVATIONS AND APPLICATIONS IN X-RAY FLUORESCENCE SPECTROMETRY

MICRO-XRF AND XRF MICROANALYSIS TRADE-OFFS BETWEEN LARGE FACILITY (SYNCHROTRON) AND LABORATORY APPROACHES ...... 142 Ursula Fittschen

TOTAL ELEMENT DETERMINATION AND SPECIATION OF ARSENIC IN AIRBORNE PARTICULATE MATTER BY COMBINING ED/WDXRF, HPLC-ICP-MS AND XANES ANALYSES ...... 142 Christine Vanhoof, Kristof Tirez, Jan Peters, Patrick Berghmans, Elke Adriaensens, Edward Roekens, Florian Meirer, Christina Streli

ON THE USE OF X-RAY FLUORESCENCE IN CULTURAL HERITAGE STUDIES: A PORTUGUESE TESTIMONY...... 143 Jose Mirao, Antonio Candeias

GEOGRAPHICAL PROFILING OF SAND USING MICRO-XRF AND TRACE ELEMENT ANALYSIS...... 144 Sergey Mamedov

SPECTROSCOPY EMERGING LEADER IN MOLECULAR SPECTROSCOPY AWARD SYMPOSIUM HONORING MATTHEW BAKER

DISCRETE FREQUENCY VIBRATIONAL SPECTROSCOPIC IMAGING: DEVELOPMENT AND PROSPECTS...... 144 Rohit Bhargava

RECENT APPLICATIONS OF ATR-FTIR SPECTROSCOPIC IMAGING ...... 145 Sergei Kazarian, Andrew Ewing

SESORS FOR SUBSURFACE TISSUE MONITORING ...... 145 Nick Stone, Ben Gardner, Pavel Matousek

CLINICAL APPLICATIONS FOR FAR-FIELD AND NEAR-FIELD FTIR IMAGING ...... 145 Kathleen Gough

TAKE MY BREATH AWAY: NON-INVASIVE BREATHOMICS FOR BACTERIAL DETECTION ...... 146 Roy Goodacre

VIBRATIONAL SPECTROSCOPY AND ADVANCED STATISTICS FOR MEDICAL DIAGNOSTICS

LABEL-FREE DIAGNOSTICS BY FTIR SPECTROSCOPY ...... 147 Klaus Gerwert

A NOVEL RAMAN SPECTROSCOPIC METHOD FOR EARLY DIAGNOSIS OF OSTEOARTHRITIS ...... 148 Mustafa Unal, Ozan Akkus

OPTIMIZATION OF THE ANALYSIS ROUTINES FOR RAMAN SPECTRA...... 149 Thomas Bocklitz, Shuxia Guo, Oleg Ryabchykov, Ralf Heinke, Thomas Doerfer, Stephan Stoeckel, Jürgen Popp

RAMAN MICROSCOPY OF BLADDER CANCER CELLS EXPRESSING GREEN FLUORESCENT PROTEIN...... 149 Gurjit S. Mandair, Amy Han, Evan T. Keller, Michael D. Morris

DDR2 DETECTION LEADING TO CANCER DIAGNOSTICS ...... 150 Alexandre Girard, Corinna Wetherill, Karen Faulds, Duncan Graham

CURRENT APPLICATIONS OF DIFFUSE REFLECTANCE SPECTROSCOPY

THE INTERFACING OF DIFFUSE RELECTANCE PROBES TO MONITOR AND CONTROL CONTINUOUS SOLID DOSE MANUFACTURING...... 150 Ke Hong, Angela Liu, Stephen Hammond

PENALTY BASED METHODS FOR CALIBRATION MAINTENANCE ...... 151 John Kalivas

INFRARED REFLECTANCE SPECTROSCOPY FOR DETECTION AND CLASSIFICATION OF MINERAL COMPONENTS ...... 151 Neal Gallagher, Toya Beiswengerjames Szecsody, Timothy Johnson

CHEMOMETRICS FOR NIR IN THE REAL WORLD: WHAT WE’VE LEARNED OVER 20 YEARS...... 152 Wendy Flory, Mary Beth Seasholtz

NEAR INFRARED SPECTROSCOPIC REMOTE SENSING OF PULSES FROM EXTRASOLAR PLANETS...... 152 Robert Lodder, Anne Brooks

CAPILLARY ELECTROPHORESIS APPLICATIONS

SEQUENCE-DEPENDENT ELECTROPHORETIC MIGRATION OF DNA AT HIGH SALT CONCENTRATION IN CZE ...... 153 Linda McGown, Jia Zhao, Steven Cramer

RECENT DEVELOPMENT IN COMPLEX GLYCAN ANALYSIS BY CE-MS ...... 153 David Chen

TETRABUTYLAMMONIUM, A DNA DENATURANT ...... 154 Earle Stellwagen, Nancy Stellwagen

MULTIPLE MODES APPLICATION OF CAPILLARY ELECTROPHORESIS IN APTAMERS SELECTION ...... 154 Qu Feng

CHARACTERIZATION OF NOVEL CHIRAL HELICAL MOLECULES BY CAPILLARY ELECTROPHORESIS ...... 155 Dusan Koval, Harish Talele, Lukas Severa, Jan Vavra, Paul E. Reyes-Gutierrez, Filip Teply, Vaclav Kasicka

MICROFLUIDICS AND MINATURIZATION

THIOLENE-BASED MICROFLUIDIC DEVICES FOR APPLICATIONS IN DRUG METABOLISM STUDIES...... 156 Jörg Kutter, Cornelia Zapp, Unai Ortiz De Orruno Cuesta, Josiane Lafleur

COUPLING FREQUENCY-SELECTIVE DIELECTROPHORETIC BIOMARKER ENRICHMENT WITHIN PHYSIOLOGICAL MEDIA TO ELECTROCHEMICAL DETECTION ...... 156 Nathan Swami, Ali Rohani, Walter Varhue, Kuo-Tang Liao, Chia-Fu Chou

ASSEMBLED MICROFLUIDIC PLATFORMS AND MOONSHINE ...... 157 Carlos Garcia, Mauro S. Ferreira Santos, Eric Da Costa, Ivano Gutz

NANOGELS: NEW MATERIALS TO PROGRAM, ERASE, AND REDESIGN LIQUID PHASE SEPARATIONS...... 158 Lisa Holland, Srikanth Gattu, Cassandra Crihfield, Brandon Durney, Grace Weisenmiller

BIOANALYTICAL APPLICATIONS OF MICROCHIP ELECTROPHORESIS WITH COUPLED CHANNELS ...... 158 Marián Masár, Peter Troška, Marína Rudašová, Jasna Hradski, Róbert Bodor

INTEGRATION OF LIBS IN THE ANALYTICAL LABORATORY

TOWARDS THE INTEGRATION OF LIBS IN THE CRITT MATÉRIAUX ALSACE ANALYTICAL LABORATORY ...... 159 Frederic Pelascini, Vincent Motto-Ros

THE CRITICAL ASPECTS OF DATA ANALYSIS FOR QUANTIFICATION IN LIBS ...... 160 Bruno Bousquet

LASER INDUCED BREAKDOWN SPECTROSCOPY, AN EXAMPLE OF ITS USE AS A COMPLETE ANALYTICAL SOLUTION...... 161 Jhanis Gonzalez, Robb Hunt, Charles Sisson, Alexande Bolshakov, C. Derrick Quarles, Chunyi Liu, Jong Yoo, Richard E. Russo

LIBS FOR MONITORING THE FABRICATION OF OPTICAL CERAMICS...... 161 Mauro Martinez, Matthieu Baudelet, Romain Gaume, Sudeep Jung Pandey, Jan Hostasa, Laura Esposito

CERTIFIED ANALYSES WITH CALIBRATION-FREE LASER-INDUCED BREAKDOWN SPECTROSCOPY: A DREAM? ...... 161 Jörg Hermann

ION MOBILITY: ADDING NEW DIMENSIONS

RECENT DEVELOPMENTS IN STRUCTURES FOR LOSSLESS ION MANIPULATIONS (SLIM) FOR ENHANCED ION MOBILITY SEPARATION ...... 162 Yehia Ibrahim, Liulin Deng, Ahmed Hamid, Sandilya Garimella, Ian Webb, Xueyun Zheng, Erin Baker, Spencer Prost, Randolph Norheim, Richard Smith

GAS-PHASE ADSORPTION TO IMPROVE ION MOBILITY-MASS SPECTROMETRY ORTHOGONALITY: LINKING OBSERVED MOBILITY SHIFTS TO COLLISION CROSS SECTION AND BINDING MODELS ...... 163 Chris Hogan, Vivek Rawat, Carlos Larriba-Andaluz, Derek Oberreit, Hui Ouyang, Jikku Thomas

ION MODIFICATION - A NEW TECHNOLOGY TO ENHANCE THE SELECTIVITY OF TOF-IMS DETECTORS...... 163 Jonathan Atkinson, Alastair Clark, Bruce Grant, Steve Taylor

DRIFT GAS MODIFIERS TO ELUCIDATE CHEMICAL CLASS...... 164 Brian Clowers, Pearl Kwantwi-Barima, Kelsey Morrison, Zhihao Yu

RECENT ADVANCEMENT IN FAIMS AND FUTURE DIRECTION...... 165 Satendra Prasad, Mike Belford, Jean-Jacques Dunyach

SAS PAT TECHNICAL SECTION: PROCESS ANALYTICAL TECHNOLOGY IN THE PHARMACEUTICAL INDUSTRIES SESSION I

RESIDENCE TIME DISTRIBUTION ANALYSIS FOR A HOT MELT GRANULATION PROCESS USING POSITRON EMISSION PARTICLE TRACKING AND NIR SPECTROSCOPIC PROBES ...... 165 Patrick Wray, John Jones, Martin Vernon, Gary McGeorge

APPLICATIONS OF PAT-BASED FEEDBACK CONTROL APPROACHES PHARMACEUTICAL CRYSTALLIZATION DEVELOPMENT ...... 166 Zoltan Nagy

PROCESS DEVELOPMENT AND DESIGN SPACE DEFINITION OF A PHARMACEUTICAL INTERMEDIATE AZEOTROPIC DRYING SYSTEM VIA IN SITU FT-IR & RAMAN SPECTROSCOPIES AND FBRM...... 166 Zachary Dance, Morgan Crawford, Aaron Moment, Busolo Wabuyele

COMBINING FLUID BED PROCESS DATA WITH SPECTRAL DATA TO IMPROVE MODEL PREDICTION OF PRODUCT PERFORMANCE...... 167 Stephen W. Hoag, Ahmed Ibrahim

MANAGING UNCERTAINTY IN DESIGN SPACE...... 168 Mark Anderson, Patrick Whitcomb

BIOANALYTICAL SERS II

TARGETED MOLECULAR DETECTION IN HUMAN BIOFLUIDS ...... 168 Zachary Schultz

IN SITU REDOX ASSESSMENTS USING SERS...... 169 Colin Campbell, Victoria Camus, Kate Fisher, Lauren Jamieson, Bill Nailon, Duncan McLaren

SERS-BASED LATERAL FLOW ASSAY FOR THE RAPID AND SENSITIVE DETECTION OF SPECIFIC BIOMARKERS ...... 169 Jaebum Choo

CHALLENGES IN APPLYING SERS TO QUANTITATIVE BIOANALYTICAL MEASUREMENTS...... 169 Marc Porter, Alexis Crawford, Aleksander Skuratovsky, Colin Young

HIGHLY CONTROLLED ASSEMBLY OF MOLECULES FOR OPTIMISATION OF SERS DETECTION METHODS...... 170 Stacey Laing, Karen Faulds

INDUSTRIAL RAMAN

SOME INSIGHTS INTO PRINCIPAL COMPONENT ANALYSIS OF INDUSTRIAL RAMAN SPECTRA...... 171 Douglas Elmore

RAMAN SPECTROSCOPY STUDY OF FRYING OIL QUALITY...... 171 Jinping Dong

FLYING WITH MOLECULAR SPECTROSCOPY INSTRUMENTS ...... 171 Xiaoyun Chen

BASIC ASPECTS OF EXPERIMENTAL DESIGN IN RAMAN MICROSCOPY...... 172 Alexander Rzhevskii

ENHANCED GAS PHASE RAMAN SCATTERING USING SUBSTRATE-INTEGRATED HOLLOW WAVEGUIDES (IHWG) COUPLED TO OPTICAL FIBER PROBES ...... 173 J. Chance Carter, S. Michael Angel, Boris Mizaikoff, William E. Hunt, Anastacia M. Manuel, Josh Huntington

INNOVATIVE APPROACHES TO TEACHING ANALYTICAL CHEMISTRY

AN ACTIVE LEARNING AND REDUCED SEAT TIME APPROACH TO GENERAL CHEMISTRY ...... 173 Michelle Driessen

THE EVOLVING USE OF ELECTRONIC TOOLS IN UNDERGRADUATE ANALYTICAL TEACHING AND RESEARCH...... 174 Dwight Stoll

TEACHING CHEMICAL INSTRUMENTATION THROUGH TEAM-BASED RESEARCH PROJECTS ...... 174 Deanna O’Donnell

IN-CLASS MEASUREMENTS OF ACADEMIC PROGRESS AND CLASS MORALE...... 175 Allen R. White

CREATING A COURSE REDESIGN STRATEGY: EXAMINING AN INSTRUMENTAL ANALYSIS LABORATORY COURSE...... 175 Anna Donnell

CHARLES MANN AWARD FOR RAMAN SPECTROSCOPY PLENARY

PROCESS RAMAN: REPRODUCIBILITY DROVE CAPABILITY ...... 176 Brian Marquardt

COBLENTZ SOCIETY CRAVER AWARD PLENARY

MULTIPLEXED AND QUANTITATIVE BIOANALYSIS USING SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS)...... 177 Karen Faulds

ATMOSPHERIC-PRESSURE PLASMAS AS TOOLS FOR ATOMIC ANALYSES, MOLECULAR MASS SPECTROMETRY, AND CHEMICAL SYNTHESIS

ALTERNATIVE IONIZATION CHEMISTRIES WITH MIXED-GAS FLOWING ATMOSPHERIC-PRESSURE AFTERGLOW (FAPA) AMBIENT DESORPTION/IONIZATION (ADI) SOURCE...... 177 Sunil Badal, Shawn Michalak, Yi You, Jacob Shelley

ATMOSPHERIC-PRESSURE PLASMAS AS ELECTROCHEMICAL ELECTRODES FOR NANOMATERIAL SYNTHESIS...... 178 R. Mohan Sankaran

UNDERSTANDING AND ADVANCING SOLUTION-CATHODE GLOW DISCHARGE - OPTICAL EMISSION SPECTROMETRY ...... 179 Michael Webb, Denise Moon, Wade Maresh, Christian Decker

ATMOSPHERIC-PRESSURE IONIZATION AND TUNABLE FRAGMENTATION OF PEPTIDES BY SOLUTION-CATHODE GLOW DISCHARGE...... 179 Andrew Schwartz, Jacob Shelley, Kelsey Williams, Courtney Walton, Gary Hieftje

NEGATIVE ION CHEMISTRY IN THE FAPA-APGD SOURCE...... 180 Jaime Orejas, Jorge Pisonero, Nerea Bordel, Alfredo Sanz-Medel, Steven J. Ray

CHARLES MANN AWARD SYMPOSIUM HONORING BRIAN MARQUART

UV RAMAN SPECTROSCOPY USING A SPATIAL HETERODYNE RAMAN SPECTROMETER: PLANETARY EXPLORATION AND ON-LINE APPLICATIONS...... 180 S. Michael Angel, Nirmal Lamsal, K. Alicia Strange, Patrick Barnett

QUANTITATIVE CHARACTERIZATION OF HETEROGENEOUS PROCESSES BY RAMAN SPECTROSCOPY...... 181 Sergey Mozharov, Brian Marquardt

RAMAN SPECTROSCOPY - NO LONGER THE TECHNIQUE OF LAST RESORT IN PAC/PAT ...... 181 Ian R. Lewis, David J. Strachan, Maryann Cuellar, Sean Gilliam, Karen Esmonde-White, Carsten Uerpmann, Herve Lucas, Alex Pitters, Bruno Lenain

SIMULTANEOUS MEASUREMENTS OF THE PHYSICAL AND CHEMICAL PROPERTIES OF PROTEINS BY THE COMBINATION OF RAMAN SPECTROSCOPY AND DYNAMIC LIGHT SCATTERING ...... 182 E. Neil Lewis, John F. Carpenter, Matthew Brown

TRANSFORMING RAMAN SPECTROSCOPY FROM ACADEMIC THEORY TO A WORKHORSE TOOL FOR INDUSTRY...... 183 Andrew Whitley

MULTIMODAL IMAGING FOR BIOMEDICAL DIAGNOSIS AND THERAPY MONITORING

A FIBER-DELIVERED OPTOACOUSTIC GUIDE FOR PRECISE BREAST-CONSERVING SURGERY ...... 183 Ji-Xin Cheng

FLUORESCENCE LIFETIME-BASED AUGMENTED REALITY MULTIMODAL IMAGING: APPLICATIONS FOR INTRAOPERATIVE DELINEATION OF SURGICAL MARGINS AND BIOPSY GUIDANCE ...... 184 Laura Marcu

MULTIMODAL MORPHO-FUNCTIONAL OPTICAL DIAGNOSIS OF TISSUE TUMOR ...... 184 Francesco Pavone

NON-LINEAR MULTIMODAL IMAGING A POSSIBLE SOLUTION TOWARDS INTRAOPERATIVE DIAGNOSIS...... 185 Michael Schmitt, Sandro Heuke, Fisseha Bekele Legesse, Tobias Meyer, Olga Chernavskaia, Thomas Bocklitz, Juergen Popp

DIFFERENTIATING RESPONSES OF LUNG CANCER CELL LINES TO DOXORUBICIN EXPOSURE: IN VITRO RAMAN MICRO SPECTROSCOPY, OXIDATIVE STRESS AND BCL-2 PROTEIN EXPRESSION ...... 186 Zeineb Farhane, Franck Bonnier, Marcus Alexander Maher, Jane Bryant, Alan Casey, Hugh James Byrne

NUCLEAR FORENSICS

MONITORING CHRONOMETER FRACTIONATION IN ACTINIDE METALS...... 186 Dallas Reilly, Jordan Corbey, Matthew Athon, Jon Schwantes, Kellen Springer

SPECTROSCOPIC CHARACTERIZATION OF URANYL-NITRIC ACID EXTRACTION BY TRIBUTYLPHOSPHATE IN HYDROCARBON SOLVENT ...... 187 Gregory Klunder, Paul Spackman, Patrick Grant

ELEMENTAL ANALYSIS OF IMPURITY CONTENT IN GLASSES BY EXTREME ULTRAVIOLET MASS SPECTROMETRY ...... 188 Carmen Menoni, Tyler Green, Ilya Kuznetsov, Weilun Chao, Jorge Rocca, Andrew Duffin

RAPID DEBRIS ANALYSIS VIA FEMTOSECOND LASER ABLATION SAMPLING ...... 188 Jesse Ward, Andrew Duffin, Gregory Eiden

APPLICATIONS OF ABSORPTION SPECTROSCOPY AND CHEMOMETRICS FOR PLUTONIUM MONITORING IN NUCLEAR MATERIALS PROCESSING FACILITIES...... 189 Robert Lascola, Patrick O’Rourke, Edward Kyser, Michael Phillips

NANO-IR/NANO-RAMAN - I

THE IMAGING ADVANTAGE IN MOLECULAR SPECTROSCOPY...... 189 John Reffner

RAMAN MICROSCOPY – FROM THE DIFFRACTION LIMITATIONS OF OPTICS TO NANOSPECTROSCOPY...... 190 Fran Adar, Maruda Shanmugasundaram

IMPROVED SENSITIVITY OF NON-RESONANTLY EXCITED PTIR PROBES ENABLES MONOLAYER DETECTION FROM THE VISIBLE THROUGH MID-IR...... 191 Andrea Centrone, Jungseok Chae, Sangmin An, Yohan Yoon, Vladimir Aksyuk

TIP-ENHANCED PHOTO-THERMAL EXPANSION WITH TERS...... 191 Raul D. Rodriguez, Teresa Madeira, Harsha Shah, Eugene Bortchagovsky, Zoheb Khan, Dietrich R. T. Zahn

STUDIES OF POLYMER ULTRATHIN FILMS, NANOFIBERS AND SINGLE CRYSTALS BY AFM-IR AND SELECTED AREA ELECTRON DIFFRACTION ...... 192 John Rabolt

PROTEOMICS / GLYCOPROTEOMICS

THE ROLES OF GLYCAN AND GLYCOPEPTIDE ISOMERS IN THE DEVELOPMENT AND PROGRESSION OF DISEASES...... 192 Yehia Mechref, Rui Zhu, Shiyue Zhou, Yifan Huang

DECIPHERING THE PROTEOME OF LYMPHOBLASTOID CELLS FROM NASU-HAKOLA PATIENTS THROUGH A COMPLEMENTARY 2-DE AND LC-MS APPROACH...... 193 Paolo Iadarola, Roberta Salvini, Anna Maria Agresta, Antonella De Palma, Pier Luigi Mauri, Simona Viglio, Laura Fossati, Anna Bardoni

NANO-LC-ORBITRAP MS/MS-BASED QUANTITATIVE PROTEOMICS AND TRANSPCRIPTOMICS FOR UNCOVERING THE MECHANISMS OF ACTION OF ROSEMARY BIOACTIVES IN COLON CANCER: A NEW FOODOMICS APPROACH...... 194 Alberto Valdés, Virginia Garcia-Cañas, Konstantin Artemenko, Jonas Bergquist , Alejandro Cifuentes

NEW ENRICHMENT AND SEPARATION METHODS FOR PHOSPHOPROTEOMICS ANALYSIS ...... 195 Mingliang Ye, Hanfa Zou

SAMPLE PREPARATION / CONCENTRATION

LIQUID PHASE MICROEXTRACTION TECHNIQUES FOR CAPILLARY ELECTROPHORESIS/MASS SPECTROMETRY ...... 196 Doo Soo Chung, Joon Yub Kwon, Hye Ryeo Lee, Jihye Kim

EXTRACTION, CONCENTRATION AND SEPARATION OF DSDNAS USING AN OPEN CAPILLARY WITHOUT AN APPLIED ELECTRIC FIELD...... 196 Cornelius Ivory, Jeffrey Burke, Sarah Friedrich, Tza-Huei Wang, Kelvin Liu

MICRO-ELECTROMEMBRANE EXTRACTION ACROSS MULTIPLE ORGANIC AND AQUEOUS PHASES. A NEW TOOL FOR SELECTIVE PRETREATMENT OF BIOLOGICAL FLUIDS...... 197 Pavel Kubán, Petr Bocek, Knut Fredrik Seip, Astrid Gjelstad, Stig Pedersen-Bjergaard

CHALLENGES ENCOUNTERED USING CE-LEDIF/ HIGH THROUGHPUT DNA SEQUENCING FOR APTAMER SELECTION...... 198 Francois Couderc, Audrey Ric, Vincent Ecochard, Audrey Boutonnet, Frederic Ginot, Varravaddheay Ong-Meang

AUTOMATED LIBS FOR PROCESS CONTROL

AUTOMATED LIBS FOR PROCESS CONTROL...... 199 Reinhard Noll, C. Fricke-Begemann, S. Connemann, C. Meinhardt, V. Sturm

AUTOMATED PROCESS ANALYSIS – LIBS TAKES ROOT...... 200 Tino Seger, Dominik Schiller, Christoph Scholz

CEREAL ANALYSIS WITH LASER INDUCED BREAKDOWN SPECTROSCOPY ...... 201 Gonca Bilge, Banu Sezer, Ismail Hakki Boyaci, Kemal Efe Eseller, Halil Berberoglu, Hamit Koksel

HIGH THROUGHPUT ONLINE LIBS MONITORING ...... 201 Francois Doucet, Lutfu Ozcan

SOLVING INDUSTRIAL PROBLEMS WITH SPECTROSCOPIC IMAGING

SOLVING PROBLEMS IN TABLET DISSOLUTION USING FTIR SPECTROSCOPIC IMAGING ...... 202 Sergei Kazarian, Andrew Ewing

THE INFLUENCE OF INTERMOLECULAR FORCES ON AMORPHOUS STABILITY PROBED BY TERAHERTZ AND LOW-FREQUENCY RAMAN SPECTROSCOPY ...... 202 Michael Ruggiero, J. Axel Zeitler

STUDYING THE EFFECT OF HUMIDITY ON NIFEDIPINE/PVP SOLID DISPERSION STABILITY USING FT-IR SPECTROSCOPY...... 203 Abdulrahman Aloumi, Ka Lung Andrew Chan

RAPID DISCRIMINATION OF POLYMORPHIC CRYSTAL FORMS BY NONLINEAR OPTICAL STOKES ELLIPSOMETRIC MICROSCOPY ...... 204 Garth Simpson, Paul D. Schmitt, Emma L. Kerian, Ximeng Y. Dow

A SYSTEMATIC EVALUATION OF SPECTROSCOPIC PROCESS ANALYTICAL TECHNOLOGIES TO INFORM IMPLEMENTATION INTO A CONTINUOUS PROCESS...... 205 David Myers, Lukas Barnes, Bryan Castle, Tony Cooper, Jimmy Engle, Aaron Garrett, Evan Hetrick, Michael Miller, Zhenqi Shi, Robert Glenn Rupard

EMERGING RAMAN II

RAMAN MICROSCOPY BEYOND THE RESOLUTION LIMIT...... 205 Katsumasa Fujita

SEEING THINGS IN A NEW LIGHT: BRILLOUIN/RAMAN MICROSCOPE FOR PHYSICO-CHEMICAL MICROSCOPIC ANALYSIS ...... 206 Vladislav Yakovlev

RAMAN SIGNAL ENHANCEMENT VIA QUANTUM COHERENCE ...... 206 Dmitri Voronine, Marlan Scully

LOW CONTENT AND MULTIPLE ANALYTE QUANTIFICATION IN THE SOLID-STATE BY RAMAN SPECTROSCOPY: AN ALTERNATIVE TO HPLC?...... 207 Alan Ryder, Boyan Li, Amandine Calvet, Yannick Casamayou-Boucau, Cheryl Morris

ANTI-REFLECTION COATING FOR BOOSTING TIP-ENHANCED RAMAN SPECTROSCOPY PERFORMANCE...... 208 Evgeniya Sheremet, Raul D. Rodriguez, Ashutosh Mukherjee, Michael Hietschold, Dietrich R. T. Zahn

BIOANALYTICAL SERS III

DEVELOPMENT AND DEPLOYMENT OF ROBUST SERS FOR MULTIPLEXED MICROBIAL QUANTIFICATION ...... 208 Karen Faulds, Kirsten Gracie, Duncan Graham, Samuel Mabbott, Hayleigh Kearns, Roy Goodacre

SERS AS A NOVEL APPROACH FOR ULTRA-SENSITIVE MAGNETIC IMMUNOASSAYS ...... 209 Jianlin Yao

ELECTROCHEMICAL SURFACE-ENHANCED RAMAN SPECTROSCOPY (EC-SERS) – A TOOL FOR EXPLORING PROTEIN-BIOMEMBRANE INTERACTIONS AT THE MOLECULAR LEVEL ...... 210 Christa Brosseau, Reem Karaballi, Soraya Merchant, Sasha Power

SERS FOR THE DETECTION OF LOW MOLECULAR WEIGHT BIOTHIOLS IN UMBILICAL CORD WHOLE BLOOD ...... 210 Bernhard Lendl, Julia Kuligowski, Marwa R. El-Zahry, Ángel Sánchez-Illana, Guillermo Quintás, Máximo Vento

SURFACE ENHANCED RAMAN SPECTROSCOPY-BASED NANOSENSORS FOR IN VIVO IN SITU OXIDATION-REDUCTION-POTENTIAL SENSING IN LUNG INJURY ...... 210 Samuel Stanfield, Sarah McAughtrie, Mark Bradley, Colin Campbell

BOTTOM-UP PLASMONIC NANOPARTICLES: SPECTROSCOPIC APPLICATIONS

CONTROLLING THE PLASMON EXCITATION OF TRIANGULAR GOLD NANOPRISMS ENABLES DETECTION OF YOCTOMOLE MICRORNAS ...... 211 Rajesh Sardar, Thakshila Liyanage

COLLOIDAL LITHOGRAPHY ON FLEXIBLE PLASTIC SUBSTRATES...... 212 Laura Sagle, Jie He, Sarah Unser

HOW TO MAKE SURFACE CHEMISTRY ON GOLD NANOSTARS PROMOTE REPRODUCIBLE SMALL MOLECULE DETECTION...... 212 Amanda Haes, Wenjing Xi

PLASMONIC MOLECULES FOR PROBING CONDUCTIVITY WITH LIGHT...... 213 Bjoern Reinhard

FLEXIBLE SERS SUBSTRATES FOR THE DETECTION OF SMALL MOLECULES ...... 213 Li-Lin Tay, John Hulse, Jeff Fraser, Sarah Milliken, Shawn Poirier

IR, RAMAN AND NONLINEAR SPECTROSCOPIES OF SURFACES AND BOUNDARIES

IR PMAIRS: A CUTTING-EDGE TOOL TO REVEAL THE MOLECULAR ORIENTATION IN AN ULTRATHIN FILM ...... 214 Takeshi Hasegawa

MOLECULAR ORIENTATION AND CONFORMATION OF FLUORINATED POLYMERS AT INTERFACE STUDIED BY VIBRATIONAL SUM FREQUENCY GENERATION SPECTROSCOPY...... 214 Masanari Okuno, Taka-Aki Ishibashi

MOLECULAR STRUCTURES OF PEPTIDES AND PROTEINS AT INTERFACES STUDIED BY LINEAR AND NONLINEAR VIBRATIONAL SPECTROSCOPIC TECHNIQUES...... 215 Zhan Chen

INFRARED SPECTROSCOPY AS A TOOL FOR STUDYING INTERSTELLAR DUST CHEMISTRY ...... 215 Tetsuya Hama, Akira Kouchi, Naoki Watanabe

TOTAL INTERNAL REFLECTION (TIR) RAMAN SPECTROSCOPY...... 216 Colin Bain

TUESDAY POSTERS – ITP – LIQUID PHASE SEPARATION METHODS

HPLC ANALYSIS OF FLUORESCENTLY LABELLED FATTY ACIDS IN FOOD SAMPLES USING AN ORGANIC MONOLITHIC COLUMN AND A BUTYL SILICA COLUMN...... 217 Murthy Jonnada, Ziad El Rassi, Guadalupe Davila El Rassi

HOW TO SELECT RELEVANT VARIABLES IN NON-TARGETED METABOLOMICS DATA? DIFFERENT STATISTICAL APPROACHES ...... 217 Renata Bujak, Emilia Daghir - Wojtkowiak, Roman Kaliszan, Michal Jan Markuszewski

STRATIFIED POLAR SILICA BONDED STATIONARY PHASES FOR HILIC AND AFFINITY CHROMATOGRAPHY AT REDUCED NONSPECIFIC INTERACTIONS...... 218 Renuka Rathnasekara, Ziad El Rassi

DESIGNING HIGHLY-SENSITIVE ELECTRICAL IMPEDANCE BASED MICROFLUIDIC FLOW SENSORS ...... 219 Pengfei Niu, Brian J. Nablo, Darwin R. Reyes

SIMULTANEOUS DETERMINATION OF HUMAN BIOGENIC AMINES AND THEIR METABOLITES WITH THE USE OF HYDROPHILIC INTERACTION CHROMATOGRAPHY PRECEDED BY MICROEXTRACTION AS THE PRECONCENTRATION TOOL...... 220 Tomasz Baczek, Lucyna Konieczna, Anna Roszkowska

TUNABLE SHORT-PASS FILTER FOR RECOVERING LONG DNA USING AN ENTROPIC TRAP ...... 221 Pranav Agrawal, Kevin D. Dorfman

NON-TARGETED HIGH RESOLUTION TANDEM MASS SPECTROMETRY (HR-MS/MS) SCREENING AND MUTAGENICITY EVALUATION OF PHOTO-DEGRADATION PRODUCTS OF TARTRAZINE (E102) IN A COMMERCIAL SOFT DRINK...... 221 Karthik Yamjala, Meyyanathan Subramania Nainar

THE EFFECT OF PH ON THE PARTITIONING OF POLYCHLORINATED BIPHENYLS (PCBS) BETWEEN SEDIMENT GRAIN SIZES AND WATER...... 222 Gbadebo Adeyinka, Brenda Moodley

MONOLITHIC STATIONARY PHASES WITH INCORPORATED NANOPARTICLES AS CHROMATOGRAPHIC SEPARATION MEDIA FOR HIGH PERFORMANCE LIQUID CHROMATOGRAPHY AND CAPILLARY ELECTROCHROMATOGRAPHY ...... 222 Nisansala Ganewatta, Ziad El Rassi

COMPARISON OF LIPOSOME- AND OCTANOL-WATER DISTRIBUTION CONSTANTS OF ANTIOXIDANTS...... 223 Susanne Wiedmer, Jana Vanova, Petr Cesla

DISTRIBUTION CONSTANTS OF LOCAL ANESTHETICS BETWEEN AQUEOUS AND LIPOSOME PHASES...... 224 Susanne Wiedmer, Suvi-Katriina Ruokonen, Filip Dusa, Paula Holma, Alexandra Robciuc, Antti Rantamäki, Juha Holopainen

PREDICTION OF GRADIENT RETENTION DATA OF OLIGOMERIC SERIES IN HILIC ...... 225 Nikola Vankova, Petr Cesla

DEVELOPMENT AND VALIDATION OF HPLC-MS/MS METHOD FOR THE SIMULTANEOUS DETERMINATION OF SEVENTEEN METABOLITES IN HUMAN URINE...... 226 Michal Jan Markuszewski, Arlette Yumba Mpanga, Danuta Siluk, Julia Jacyna, Oliwia Szerkus, Renata Bujak, Marcin Markuszewski, Marcin Matuszewski, Roman Kaliszan

A NEW APPROACH TO INVESTIGATE MICROFLUIDIC SUBSTRATES: EXAMINATION OF AIR PLASMA TREATED PDMS SAMPLES BY INVERSE GAS CHROMATOGRAPHY ...... 227 András Guttman, Gábor Járvás, Márton Szigeti, László Hajba, András Dallos, Brigitta Mészáros

µLAS, A DISRUPTIVE TECHNOLOGY FOR SIZE ANALYSIS OF DNA WITH UNRIVALLED SENSITIVITY : APPLICATION FOR CIRCULATING CELL FREE DNA ANALYSIS ...... 227 Audrey Boutonnet, Comtet Louis Andriamanampisoa, Aurélien Bancaud, Jacques Favre, Frédéric Ginot, Arnaud Morin, Vincent Picot, Laure Saias

DEVELOPMENT OF A SCANNING MICROFLUIDIC CHROMATOGRAPHY SYSTEM FOR BINDING ASSAYS WITH NEAR INFRARED FLUORESCENCE DETECTION ...... 228 Elliott Rodriguez, John Vargas, Benjamin Hage, Michael Stoller, Stephen Morrin, David Hage

1H-NMR SPECTROSCOPY TO ANALYZE THE METABOLOME OF EXHALED BREATH CONDENSATE FROM ALPHA1-ANTITRYPSIN DEFICIENT (AATD) PATIENTS AND HEALTHY CONTROLS ...... 229 Marco Fumagalli, Jan Stolk, Carlotta Ciaramelli, Rita Bussei, Valeria Mazzoni, Simona Viglio, Paolo Iadarola, Cristina Airoldi

DEVELOPMENT OF A NMR-BASED APPROACH TO EVALUATE THE METABOLOME OF BALF FOR BIOMARKER IDENTIFICATION OF BRONCHIOLITIS OBLITERANS SYNDROME (BOS) ...... 230 Cristina Airoldi, Carlotta Ciaramelli, Marco Fumagalli, Sara Magni, Simona Viglio, Davide Piloni, Annamaria Bardoni, Maddalena Cagnone, Federica Meloni, Paolo Iadarola

OPTIMIZATION OF ON-COLUMN ENTRAPMENT CONTAINING HUMAN SERUM ALBUMIN FOR THE STUDY OF DRUG-PROTEIN BINDING BY HIGH PERFORMANCE AFFINITY CHROMATOGRAPHY ...... 230 Shiden Azaria, John Vargas, David Hage

ANALYSIS OF DRUG BINDING WITH SOLUBLE PROTEINS BY USING ULTRAFAST AFFINITY EXTRACTION AND ALPHA1-ACID GLYCOPROTEIN MICROCOLUMNS ...... 231 Sandya Rani Beeram, Xiwei Zheng, David Hage

LC-MS, CE-MS AND GC-MS URINE METABOLIC FINGERPRINTING IN RENAL CELL CARCINOMA ...... 232 Michal J. Markuszewski, Marta Kordalewska, Renata Bujak, Joanna Godzien, Arlette Yumba Mpanga, Ángeles López Gonzálves, Marcin Markuszewski, Marcin Matuszewski, Roman Kaliszan, Coral Barbas

AFFINITY PURIFICATION OF MONOCLONAL ANTIBODY USING A LAB-ON-A-CHIP DEVICE ...... 233 Mehnaz Mursalat, Mengxin He, Natalija Tasovac, Sagnik Basuray

TUESDAY POSTERS – LIBS II

RADIAL DISTRIBUTION OF ELECTRON DENSITY AND TEMPERATURE IN LASER-INDUCED PLASMA...... 233 Ghaneshwar Gautam, Christian Parigger

IN-SITU MEASUREMENTS OF CALCIUM CARBONATE DISSOLUTION UNDER RISING PCO2 USING UNDERWATER LASER INDUCED BREAKDOWN SPECTROSCOPY ...... 234 Jinesh Jain, Christian Goueguel, Dustin McIntyre, Cantwell Carson, Harry Edenborn

IN-SITU APPLICATIONS OF FIELD-PORTABLE HANDHELD LIBS ANALYZERS WITH EXPANDED SPECTRAL RANGE ...... 235 Brendan Connors, David Day, Morgan Jennings

LASER INDUCED FLUORESCENCE FOR ARSENIC DETECTION IN LASER INDUCED PLASMAS...... 235 Jonathan Merten, Christopher Jones

SUBSTRATE-ENHANCED LIBS FOR ANALYZING LIQUID SAMPLES...... 236 Qun Li, Sean Wang

LASER-INDUCED BREAKDOWN SPECTROSCOPY FOR ELEMENTAL CHARACTERIZATION OF CALCITIC ALTERATIONS ON CAVE WALLS...... 236 Bruno Bousquet, Lena Bassel, Vincent Motto-Ros, Florian Trichard, Frederic Pelascini, Faten Ammari, Remy Chapoulie, Catherine Ferrier, Delphine Lacanette

MULTI-BLOCK ANALYSIS COUPLED TO LASER-INDUCED BREAKDOWN SPECTROSCOPY FOR ELEMENTAL CHARACTERIZATION OF GEOLOGICAL MATERIALS FROM CAVES...... 237 Bruno Bousquet, Faten Ammari, Lena Bassel, Catherine Ferrier, Delphine Lacanette, Remy Chapoulie

INVESTIGATING ANALYTE TRANSPORT IN SOLUTION-CATHODE GLOW DISCHARGE USING WAVELENGTH-RESOLVED IMAGING...... 237 Denise Moon, Michael R. Webb

A DEPTH PROFILING METHOD FOR MEASURING HELIUM RETENTION IN TUNGSTEN USING LASER BASED CHARACTERIZATION TECHNIQUES...... 238 Guinevere Shaw

FACILITATING DIATOMIC METAL OXIDE FORMATION IN FEMTOSECOND-LASER-INDUCED PLASMAS ...... 239 Yonghoon Lee, Xianglei Mao, George C.-Y. Chan, Jhanis J. Gonzalez, Richard E. Russo, Vassilia Zorba

ACCURATE ANALYSIS OF SULFUR IN EDIBLE SALTS BY USING LASER-ABLATION SAMPLING ...... 239 Yonghoon Lee, Jose Chirinos, Jhanis Gonzalez, Dayana Oropeza, Vassilia Zorba, Xianglei Mao, Jonghyun Yoo, Richard E. Russo

TUESDAY POSTERS - RAMAN

PROBING THE MECHANISM OF CHARGE TRANSFER IN ORGANIC CRYSTALS USING FEMTOSECOND STIMULATED RAMAN SPECTROSCOPY ...... 240 Alyssa Cassabaum, Renee Frontiera

ELUCIDATING MOLECULAR STRUCTURE IN NEW ZEALAND NATIVE CHITON AND FEATHERS USING RAMAN SPECTROSCOPY AND DENSITY FUNCTIONAL THEORY...... 240 Keith Gordon

HUMAN AND ANIMAL BLOOD DIFFERENTIATION USING RAMAN SPECTROSCOPY AND CHEMOMETRICS...... 241 Kyle C. Doty, Gregory McLaughlin, Igor K. Lednev

VIBRATIONAL ASSIGNMENTS AND CONFORMER STABILITY DETERMINATION OF CYCLOBUTYLDICHLOROSILANE BY VARIABLE TEMPERATURE RAMAN SPECTRA IN KRYPTON SOLUTION ...... 242 Reid Brenner, Bhushan Deodhar, Dattatray Sawant, Gamil Guirgis, Yannick Geboes, Wouter Herrebout, James Durig

INNOVATIVE APPLICATIONS OF RAMAN MICROSCOPY ...... 242 Sergey Shilov, Peng Wang, Juergen Sawatzki, Thomas Tague

MICROCAVITY RAMAN SENSING: IMPROVED SYSTEM STABILITY FOR QUANTITATIVE ANALYSIS...... 243 Adam J. Hopkins, Benjamin Petrak, Andreas Muller

STUDY THE INTERACTION BETWEEN MONOCLONAL ANTIBODY (MAB) PHARMACEUTICALS AND SDS BY USING DEEP-UV RESONANCE RAMAN (DUVRR) SPECTROSCOPY WITH TWO-DIMENSIONAL (2D) CORRELATION ANALYSIS...... 243 Chen Qiu, Sergey Arzhantsev, John Kauffman

ADVANCED CHEMICAL IMAGING OF HAIR FIBER: THE COMBINATION OF CONFOCAL RAMAN MICROSCOPY AND BAND TARGET ENTROPY MINIMIZATION ...... 244 Shuying Cheng, Liangfeng Guo, Nuan Qin Ong, Marc Garland

TEMPERATURE- AND ULTRAVIOLET IRRADIATION -INDUCED STRUCTURAL CHANGES OF POLYLACTIDE AND POLY(L-LACTIDE)/POLY(D-LACTIDE) STEREOCOMPLEX STUDIED BY RAMAN AND TERAHERTZ SPECTROSCOPIES...... 245 Moe Nakamura, Harumi Sato, Hiromichi Hoshina, Yukihiro Ozaki

PIEZORESISTANCE STRAIN SENSING IN SINGLE CARBON FIBERS EPOXY COMPOSITES USING RAMAN SPECTROSCOPY ...... 246 Nataliya Kalashnyk, Eric Faulques, Jan Schjødt-Thomsen, Lars R Jensen, Jens Chr M Rauhe, Ryszard Pyrz, Dale L Perry

PROBING THE MECHANISM OF PHOTOINDUCED ELECTRON TRANSFER IN BETAINE-30 IN SOLUTION AND SOLID PHASES ...... 246 Ruchira Silva, Alyssa Cassabaum, Renee Frontiera

INVESTIGATION OF ß-CAROTENE AND LYCOPENE AGGREGATION STRUCTURE IN TOMATO USING UV-VIS AND RAMAN SPECTROSCOPY ...... 247 Phiranuphon Meksiarun, Ishigaki Mika, Hideki Hashimoto, Toshihiko Kakitsubo, Takuma Genkawa, Yukihiro Ozaki

RAMAN SPECTROSCOPIC SCREENING METHODS FOR LUNG CANCER DETECTION ...... 248 Jeongho Kim, Wansun Kim Kim, Seungho Lee, Yongjin An An, Eunjung Kim, Hyung Woo Choi, Jae Hyung Kim, Boksoon Chang, Samjin Choi, Hun-Kuk Park

DEVELOPMENT OF AN EFFICIENT ROBUST CALIBRATION MODEL OF SPECTROSCOPIC SYSTEMS BY INCORPORATING VARIATIONS OF PURE COMPONENTS: A PHARMACEUTICAL TABLET ASSAY EXAMPLE ...... 248 Md Nayeem Hossain, Carl Anderson, James Drennen

GATED RAMAN TO SUPPORT MINING OPERATIONS ...... 249 Paul Bartholomew, Jouni Takalo, Mari Tenhunen

REPRESENTATIVE SAMPLING IN SOLIDS AND TURBID MEDIA FOR PROCESS RAMAN MEASUREMENTS DURING CONTINUOUS OR BATCH MANUFACTURING OPERATIONS...... 250 Karen Esmonde-White, Carsten Uerpmann, Sean Gilliam, Lisa Ganster, Ian Lewis

RAMAN SPECTROSCOPY IN POLYMER PROCESSING APPLICATIONS ...... 251 Lisa Ganster, Karen Esmonde-White, Ian Lewis

FUNDAMENTALS AND APPLICATIONS OF LASER ABLATION

FEMTOSECOND LASER ABLATION-ICPMS: BEAM HOMOGENIZATION AND DELIVERY BY TWO- STAGE FOURIER OPTICAL PROCESSING ...... 251 Joachim Koch, Debora Käser, Detlef Günther

LASER IONIZATION MASS SPECTROMETRY IS NOT THE POOR MAN...... 252 Jose Vadillo, Samara Medina, J. Javier Laserna

SOLID SAMPLE ANALYSIS BY A TANDEM LIBS AND LA-ICP-MS SYSTEM: USE OF CHEMOMETRICS TOOLS FOR DATA REDUCTION AND INTERPRETATION ...... 252 Jhanis Gonzalez

MAPPING THE ELEMENTAL DISTRIBUTION IN DIFFERENT TYPES OF RICE GRAINS USING LASER ABLATION ICP-MS ...... 253 Todor Todorov, Patrick Gray

MATRIX-FREE AMBIENT PRESSURE UV-LAESI MASS SPECTROMETRY FOR PLANT METABOLITE IMAGING ...... 253 Patrick McVey, Katherine-Jo Galayda, Liza Alexander, Basil Nikolau, R. S. Houk

COBLENTZ CRAVER AWARD SYMPOSIUM HONORING KAREN FAULDS

DETECTION OF DRUGS AND DRUG METABOLITES USING SERS...... 254 Roy Goodacre, Abdu Subaihi, Omar Alharbi, Yun Xu

DETECTION OF MYCOPLASMA WITH SERS. PROGRESS TOWARDS CLINICAL APPLICATIONS...... 254 Richard Dluhy

DEVELOPMENT OF MICRO-SCALE SPATIALLY OFFSET RAMAN SPECTROSCOPY (MICRO-SORS) FOR ANALYSIS OF THIN TURBID LAYERS ...... 255 Pavel Matousek, Claudia Conti, Chiara Colombo, Marco Realini

WHAT FACTORS REALLY MATTER IN QUANTITATIVE SERS? ...... 255 Steven Bell

SHE – SERS, HATS AND ENZYMES ...... 256 Duncan Graham, Karen Faulds, Ewen Smith

SERS AND SESORS FOR BIOMEDICAL APPLICATIONS

SERS AS POWERFUL TOOL IN FOOD AND DRUG MONITORING ...... 257 Dana Cialla-May, Karina Weber, Juergen Popp

SURFACE-ENHANCED SPATIALLY-OFFSET RAMAN SPECTROSCOPY (SESORS) IN TISSUES ...... 258 Steven Asiala, Jonathan Noonan, Gianluca Grassia, Neil Macritchie, Neil Shand, Pasquale Maffia, Paul Garside, Iain McInnes, Karen Faulds, Duncan Graham

SESORS FOR NEUROSCIENCE...... 258 Amber Moody, Bhavya Sharma

DYNAMIC SERS OPTOPHYSIOLOGY: PLASMONIC NANOSENSING FOR MONITORING CELL SECRETION EVENTS ...... 259 Jean-Francois Masson, Felix Lussier, Thibault Brule

DEVELOPMENT OF NANOSENSORS FOR THE DETECTION OF CARDIOVASCULAR DISEASE BIOMARKERS USING SERS ...... 259 Kirsten Gracie, Steven Asiala, Jonathan Noonan, Neil Macritchie, Gianluca Grassia, Pasquale Maffia, Karen Faulds, Duncan Graham

NANO-IR/NANO-RAMAN - II

ETALON TIP-ENHANCED RAMAN SPECTROSCOPY...... 260 Evgeniya Sheremet, Raul D. Rodriguez, Ashutosh Mukherjee, Michael Hietschold, Dietrich R. T. Zahn

HOW TO INVESTIGATE PARCHMENT ALTERATION BY AFM-IR...... 260 Ariane Deniset-Besseau, Alexandre Dazzi, Laurianne Robinet, Gael Latour, Marie-Claire Schanne-Klein

TERS: PER ASPERA AD ASTRA...... 261 Andrey Krayev

NANOSCALE CHEMICAL IMAGING BY PHOTO-INDUCED FORCE MICROSCOPY...... 262 Ryan Murdick, Will Morrison, Katie Park, Derek Nowak, Tom Albrecht, Sung Park

TIP ENHANCED RAMAN SPECTROSCOPY IMAGING OF OPAQUE SAMPLES IN ORGANIC LIQUID ...... 262 Emmanuel Maisonhaute, Thomas Touzalin, Alice Dauphin, Suzanne Joiret, Ivan Lucas

HPLC AND LC-MS

MICROSCALE SPECIFIC SEPARATIONS USING FULLERENES ...... 262 Koji Otsuka, Madoka Tsuzuki, Eisuke Kanao, Toyohiro Naito, Takuya Kubo

UPTAKE AND METABOLIZATION OF PHARMACEUTICALS IN PLANTS...... 263 Christian Klampfl, Lisa Emhofer, Markus Himmelsbach

DEEP PROTEOMIC PROFILING OF LIMITED SAMPLES USING ULTRA-LOW FLOW LIQUID PHASE SEPARATION TECHNIQUES COUPLED TO ADVANCED MASS SPECTROMETRY...... 264 Alexander Ivanov

HYBRID TECHNOLOGY FOR CE-MS INTERFACING...... 265 Frantisek Foret, Jana Krenkova, Karel Kleparnik, Anna Tycova

TWO-DIMENSIONAL LIQUID PHASE SEPARATIONS COUPLED WITH MASS SPECTROMETRY ...... 265 Petr Cesla, Nikola Vankova, Jana Vanova, Zuzana Novakova

DIELECTROPHORESIS II – APPLICATIONS AND METHODOLOGIES

ELECTRIC FIELD INDUCED PARTICLE ROTATION IN MICROCHANNEL ...... 266 Prashanta Dutta, Walid Rezanoor

DIELECTROPHRESIS FORCE SPECTROSCOPY FOR MICRO AND NANO PARTICLES ...... 267 H. Daniel Ou-Yang, S. Min-Tzo Wei, Jingyu Wang, Hyunjoo Park, Hao Huang

CONTACTLESS DIELECTROPHORETIC ENRICHMENT OF TUMOR INITIATING CELLS WITH ENHANCED VIABILITY VIA CELL-SCALE MICROSTRUCTURES...... 268 Rafael V Davalos, Jaka Cemazar, Temple Douglas, Eva Schmelz

SAMPLE PREPARATION: STRENGTHENING THE WEAK LINK IN MICROFLUIDICS USING CARBON- ELECTRODE DIELECTROPHORESIS ...... 268 Rodrigo Martinez-Duarte

ENHANCING DIELECTROPHORETIC PARTICLE MANIPULATION ...... 269 Blanca H. Lapizco-Encinas

FUSION OF LIBS WITH OTHER TECHNIQUES

LASER INDUCED BREAKDOWN SPECTROSCOPY FOR FOOD ANALYSIS ...... 270 Ismail Hakki Boyaci, Gonca Bilge, Banu Sezer, Kemal Efe Eseller, Halil Berberoglu

USE OF SIMULTANEOUS VACUUM UV PLASMA SPECTROSCOPY FOR LIBS IMPROVEMENT...... 271 Pavel Veis, Jaroslav Kristof

NOVEL ANALYTICAL APPLICATION OF LIBS USING EXTERNAL ELECTRIC AND MAGNETIC FIELDS ...... 272 Prasoon Diwakar, Payson Dieffenbach, Ahmed Hassanein

UTILIZATION OF COMPUTED TOMOGRAPHY AND LASER SPECTROSCOPY FOR 3D HIGH RESOLUTION MAPPING ...... 273 Pavel Porízka, Tomáš Zikmund, Markéta Tesarová, David Prochazka, Jan Novotný, Jozef Kaiser

LIBS FOR RECOGNITION OF NATURAL HEALTH PRODUCTS AND PROCESS CONTROL ...... 273 Josette El Haddad, Aissa Harhira , Mohamad Sabsabi, Alain Blouin, Camilo Martinez-Farina, Fabrice Berrué, Bob Chapman

ION MOBILITY: NEW INSIGHTS INTO ASSEMBLY, INTERACTIONS, AND STRUCTURES

DIFFERENTIAL METAL ION ADDUCTION, GAS-PHASE ION CHEMISTRY, AND THEIR COMBINED POTENTIAL FOR DISTINCTION OF ISOMERIC CARBOHYDRATES BY ION MOBILITY SPECTROMETRY ...... 274 Eric D. Dodds, Yuting Huang, Katherine N. Schumacher, Abby S. Gelb, Lauren M. Petrosh

NATIVE IM-MS OF PARTIALLY UNFOLDED PROTEINS ...... 274 James Prell, Micah Donor, Jesse Wilson

CHARACTERIZING TRAPPED ION MOBILITY SPECTROMETRY (TIMS) FOR TRANSMISSION AND PRESERVATION OF NATIVE ANALYTE STRUCTURES AND THEIR COMPLEXES...... 275 Christian Bleiholder, Samuel R. Kirk, F. Caroline Liu

ANALYSIS OF NATIVE-LIKE IONS USING STRUCTURES FOR LOSSLESS ION MANIPULATION ...... 275 Matthew Bush, Samuel Allen, Rachel Eaton

SECONDARY STRUCTURE HETEROGENEITY PRESERVED INTO THE GAS PHASE...... 276 Stephen Valentine, Mahdiar Khakinejad, Samaneh Ghassabi Kondalaji

PROCESS ANALYTICAL TECHNOLOGY IN THE BIOPHARMACEUTICAL INDUSTRIES SESSION II

PROTEIN SECONDARY STRUCTURE PREDICTION USING DROP COAT DEPOSITION CONFOCAL RAMAN (DCDCR) SPECTROSCOPY...... 277 Ravi Kalyanaraman, Jeremy Peters, Anna Luczak, Varsha Ganesh, Eugene Park

UPSTREAM BIOPROCESS CHARACTERIZATION BY RAMAN SPECTROSCOPY: TRENDING, QUANTIFICATION AND CONTROL ASPECTS...... 277 John Bobiak, Dimuthu Jayawickrama, Boyong Wan, Nobel Vale

HOLISTIC MAMMALIAN CELL CULTURE INPUT RAW MATERIAL CHARACTERIZATION STRATEGY AND ITS APPLICATION...... 277 Jason Dickens

PAT APPLIED TO BIOLOGICAL MANUFACTURING: THE NEXT STEP(S) TOWARDS INFINITY AND BEYOND ...... 278 Steven Short, John Higgins, Douglas Richardson, David Pollard

BEST PRACTICES FOR THE DEVELOPMENT OF QUANTITATIVE CHEMOMETRIC MODELS FOR UPSTREAM BIOPROCESS PAT APPLICATIONS ...... 279 Saly Romero-Torres, Maryann E. Cuellar, Sean J. Gilliam

SPATIALLY OFFSET RAMAN SPECTROSCOPY (SORS)

DMD-BASED SOFTWARE-CONFIGURABLE SPATIALLY-OFFSET RAMAN SPECTROSCOPY FOR SPECTRAL DEPTH-PROFILING OF OPTICALLY TURBID SAMPLES ...... 279 Ioan Notingher, Zhiyu Liao, Faris Sinjab, Graham Gibson, Miles Padgett

AXIALLY PERPENDICULAR OFFSET RAMAN MEASUREMENT FOR DIRECT QUANTITATIVE ANALYSIS OF CONTAINED SAMPLES...... 279 Hoeil Chung

LINE-ILLUMINATION SPATIALLY OFFSET RAMAN SPECTROSCOPY(SORS) COUPLED WITH VARIOUS CURVE RESOLUTION METHOD ...... 280 Hyung Min Kim

PHOTON MIGRATION ASSESSMENT INSIDE BONES OF DIFFERING MINERAL LEVELS USING SPATIALLY OFFSET RAMAN SPECTROSCOPY ...... 280 Kay Sowoidnich, John H. Churchwell, Kevin Buckley, Allen E. Goodship, Anthony W. Parker, Pavel Matousek

SPATIALLY OFFSET RAMAN SPECTROSCOPIC PROBE FOR THROUGH BARRIER IDENTIFICATION...... 281 Phillip Wilcox, Jason Guicheteau, Ashish Tripathi, Steven Christesen

RAMAN CONTRIBUTED SESSION

QUANTITATIVE INVESTIGATION ON PKA-SERS RELATIONSHIP BY "HOT SPOT" NORMALIZATION ...... 281 Haoran Wei, Weinan Leng, Peter Vikesland

EX VIVO PH SENSING VIA FIBRE OPTIC BASED SURFACE-ENHANCED RAMAN SCATTERING (SERS) ...... 282 Sarah McAughtrie, Michael G. Tanner, Debaditya Choudhury, Yu Fei, Tushar Choudhary, Thomas Craven, Bethany Mills, Colin J. Campbell, Kevin Dhaliwal, Mark Bradley

MACROSCALE SERS UNIFORMITY AND REPRODUCIBILITY USING DENSELY CLUSTERED NANOPILLARS ...... 283 Kaiyu Wu, Michael Schmidt, Tomas Rindzevicius, Anil Thilsted, Anja Boisen

DETECTING SPECIFIC ANTIGENS USING THE CATALYTIC PROPERTIES OF SILVER NANOPARTICLES COMBINED WITH SER(R)S DETECTION ...... 283 Sian Sloan-Dennison, Neil C Shand, Duncan Graham, Karen Faulds

BIOCOMPATIBLE, LIPOSOME-BASED SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) SUBSTRATES ...... 284 Laura Sagle, William Lum, Ian Bruzas, Sarah Unser

BOTTOM-UP PLASMONIC NANOPARTICLES: SYNTHETIC STRATEGIES

A TAXONOMY OF THE MAGNETO-OPTICAL RESPONSES OF CYCLIC PLASMON-SUPPORTING METAL OLIGOMERS ...... 285 David Masiello

XPS STUDY OF THE STABILITY OF AU-NANOPARTICLE INCORPORATED OXIDES FOR OPTICAL SENSING OF H2 AT HIGH TEMPERATURES...... 286 John Baltrus, Paul Ohodnicki, Gordon Holcomb, Joseph Tylczak

SELF-ASSEMBLED, FREE-STANDING PLASMONIC NANOPARTICLE FILMS AS FLEXIBLE SERS PLATFORMS ...... 286 Jennifer S. Shumaker-Parry

LOCALIZED SURFACE PLASMON RESONANCE OF SINGLE AU-CU ALLOY NANOPARTICLES DURING GALVANIC REPLACEMENT REACTION ...... 287 Jing Zhao

METASURFACE ENHANCED RAMAN SPECTROSCOPY...... 287 Andrea Tao

FRONTIERS OF FAR-AND DEEP- ULTRAVIOLET SPECTROSCOPY I

ALUMINUM FILM-OVER-NANOSPHERE SUBSTRATES FOR DEEP-UV SURFACE-ENHANCED RESONANCE RAMAN SPECTROSCOPY...... 287 Prof. Richard P. Van Duyne

DEEP UV RESONANCE RAMAN INCISIVE PROBING OF PROTEIN AND PEPTIDE STRUCTURE AND DYNAMICS ...... 288 David Punihaole, Sanford Asher, Elizabeth M. Dahlburg, Ryan S. Jakubek, Zhenmin Hong

DUV RAMAN SPECTROSCOPY IS A VERSATILE TOOL FOR PROBING PROTEIN AGGREGATION...... 288 Igor Lednev, Tatiana Quin~ones-Ruiz, Manuel Rosario-Alomar, Juan Lopez-Garriga

DEEP UV RAMAN MICROSCOPY: SUPPRESSION OF PHOTO-DEGRADATION...... 289 Satoshi Kawata, Yasuaki Kumamoto

IMPROVEMENT OF DEEP-UV PHOTOCATALYTIC EFFECT BY SPECTROSCOPIC ANALYSIS...... 290 Yuika Saito, Mitsuhiro Honda, Yasuaki Kumamoto, Atsushi Taguchi, Satoshi Kawata

CELEBRATING THE LIFE AND LEGACY OF PROFESSOR JOE CARUSO

THE LIQUID SAMPLING-ATMOSPHERIC PRESSURE GLOW DISCHARGE (LS-APGD) MICROPLASMA: AN EXAMPLE OF WHAT I LEARNED FROM JOE CARUSO - ITS MORE FUN LIVING (A LITTLE) OUTSIDE OF THE BOX ...... 291 R. Kenneth Marcus

ANALYSIS OF SINGLE MUSCLE CELLS BY ICP-MS-MS TO EVALUATE CHANGES IN THE ION TRANSPORT RATE OF POTASSIUM...... 291 Julio Landero, Cory Stiner, Tatiana Radzyukevich, Judith Heiny

IMPROVING SENSOR SELECTIVITY WITH SPECTROELECTROCHEMISTRY...... 292 William Heineman, Samuel Bryan

DEVELOPMENT OF CELL LYSIS METHODS FOR METALLOPROTEOMICS ANALYSIS, A STUDY OF HISTOPLASMA CAPSULATUM ...... 293 Anna Donnell, Stephanie Lewis, Julio Landero, George Deepe, Anne Vonderheide

DR. JOE CARUSO: THE SCIENTIST, GRADUATE ADVISOR, PROMOTOR, MENTOR, CAREER COACH AND YES, EVEN MATCHMAKER...... 293 Peter Brown

LIPIDS AND LIPODOMICS IN HEALTH AND DISEASE

TRACKING LIPID DYNAMICS FOLLOWING CRYOLIPOLYSIS WITH COHERENT RAMAN IMAGING IN SKIN AND NERVES ...... 294 Conor Evans, Tracy Wang, Yookyung Jung, Joshua Tam, Emilia Javorsky, Lilit Garibyan, Ray Jalian, Rox Anderson

USING SPECTRAL CARS TO INTERROGATE WHITE MATTER IN HEALTH AND DISEASE ...... 294 Peter K. Stys, Craig Brideau, Geert J. Schenk, Roel Klaver, Jeroen J. G. Geurts, Kelvin W. Poon

THE APPLICATION OF LIPID-BASED STIMULATED RAMAN SCATTERING MICROSCOPY IN BRAIN TUMOR SURGERY ...... 295 Daniel Orringer

TIME-DEPENDENT DEPTH PROFILES OF SKIN HYDRATION FOLLOWING TREATMENT WITH TOPICAL PRODUCTS...... 295 Fran Adar, Catalina David, Vinent Larat

CONFOCAL RAMAN MICROSCOPY OF LECTIN PROTEIN BINDING TO MANNOSE-FUNCTIONALIZED SUPPORTED LIPID BILAYERS ...... 296 David A. Bryce, Jay P. Kitt, Joel M. Harris

CHEMOMETRICS IN CHEMICAL AND BIOLOGICAL IMAGING: FROM MACRO- TO NANO-

MULTISET ANALYSIS FOR HYPERSPECTRAL IMAGES ...... 296 Anna De Juan

COMBINING MALDI SPECTROMETRIC IMAGING AND RAMAN SPECTROSCOPIC IMAGING: A FRUITFUL MARRIAGE?!...... 297 Thomas Bocklitz, Katharina Bräutigam, Günther Ernst, Ferdinand Von Eggeling, Orlando Guntinas-Lichius, Jürgen Popp

MULTIVARIATE ANALYSIS STRATEGIES FOR MACROSCOPIC FLUORESCENCE HYPERSPECTRAL IMAGING ...... 297 Howland Jones, David Haaland, Gina Stuessy, Scott McElroy, Gabor Kemeny

ANALYSIS OF SINGLE-MOLECULE FLUORESCENCE 2D+T LIVE-CELL IMAGES ...... 298 Cyril Ruckebusch, Siewert Hugelier, Michel Sliwa, Peter Dedecker, Paul Eilers, Johan De Rooi

QUANTUM CASCADE LASER MID-INFRARED IMAGING AND RANDOM FOREST CLASSIFICATION OF PROSTATE CANCER ...... 299 Tomasz Wrobel, Virgilia Macias, Andre Kadjacsy-Balla, Rohit Bhargava

QUANTUM CASCADE LASERS - I

NONINVASIVE GLUCOSE MONITORING WITH MID-INFRARED QUANTUM CASCADE LASER SPECTROSCOPY...... 299 Alexandra Werth, Sabbir Liakat, Yezhezi Zhang, Anqi Dong

MYCOSPEC: HARNESSING QUANTUM CASCADE LASER SPECTROSCOPY FOR ON-SITE MYCOTOXIN ANALYSIS...... 300 Boris Mizaikoff, Markus Sieger, Tuba Öner, Gregor Kos, Rudolf Krska, Matthias Godejohann

QCL BASED LIQUID SENSING 2.0: A SINGLE CHIP SOLUTION...... 300 Benedikt Schwarz, Daniela Ristanic, Peter Reininger, Werner Schrenk, Hermann Detz, Tobias Zederbauer, Aaron Maxwell Andrews, Donald Craig Macfarland, Gottfried Strasser

RAPID AND PRECISE MEASUREMENTS OF CHEMICAL MIXTURES AND ISOTOPE RATIOS USING SWEPT EXTERNAL CAVITY QUANTUM CASCADE LASERS ...... 301 Mark Phillips, Matthew Taubman, Brian Brumfield

DETECTION OF EXPLOSIVES WITH DIFFERENTIAL EXCITATION SPECTROSCOPY ...... 301 Jason Cox, Boyd Hunter, Michael Miller, Paul Harrison

YOUNGS SCIENTISTS

MICROCHIP ISOTACHOPHORESIS IN THE ANALYSIS OF THE MAIN PHARMACEUTICAL COMPONENTS ...... 302 Jasna Hradski, Marína Rudašová, Róbert Bodor, Marián Masár

NANOPARTICLE CAPILLARY ELECTROKINETIC CHROMATOGRAPHY – EVALUATION OF THE RETENTION ENERGETICS OF FUNCTIONALIZED CARBON NANOTUBES AND THEIR APPLICATIONS TO THE ANALYSIS OF A WIDE RANGE OF NEUTRAL AND CHARGED SPECIES...... 303 Sarah Alharthi, Ziad El Rassi

PROTEOMIC APPROACHES TO INVESTIGATE THE SALIVARY GLANDS AND OVARY OF THE TICK IXODES RICINUS AND THE RELATIONSHIP WITH THE SYMBIONT MIDICHLORIA MITOCHONDRII ...... 304 Monica Di Venere, Maddalena Cagnone, Marco Fumagalli, Anna Maria Floriano, Alessandra Cafiso, Valentina Serra, Stuart Armstrong, Benjamin Makepeace, Davide Sassera

THE OPTIMIZATION OF PRESSURE CYCLING TECHNOLOGY (PCT) FOR DIFFERENTIAL EXTRACTION OF SEXUAL ASSAULT CASEWORK ...... 305 Vanessa Martinez, Deepthi Nori, Bruce McCord

IN VIVO MONITORING OF BRANCHED CHAIN AMINO ACID DYNAMICS USING ONLINE MICRODIALYSIS-CAPILLARY ELECTROPHORESIS ...... 305 Megan Weisenberger, Michael T. Bowser

COMBINATION OF INSULATING AND CONDUCTING POSTS TO CREATE A HYBRID DIELECTROPHORETIC DEVICE...... 306 Mario A. Saucedo-Espinosa, Blanca H. Lapizco-Encinas

SEQUENCE BASED SEPARATION OF DNA USING GEL ELECTROPHORESIS ...... 307 Wyatt Stevens, Jia Zhao, Linda McGown

COMPLEXATION OF BUFFER CONSTITUENTS WITH CHARGED COMPLEXATION AGENTS ...... 307 Milan Boublík, Martina Riesová, Pavel Dubský

DETERMINATION OF STABILITY CONSTANT OF POTASSIUM-DIBENZO-18-CROWN-6 COMPLEX IN HYDRO-ORGANIC SOLVENTS BY ACE: EVALUATION OF THE EFFECT OF MODEL FUNCTION SIMPLIFICATION...... 308 Renata Konasova, Jana Jaklova Dytrtova, Vaclav Kasicka

TRACKING BIOCHEMICAL CHANGES UNDERLYING ULTRA-WEAK PHOTON EMISSION USING CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY BASED METABOLOMICS...... 309 Rosilene Cristina Rossetto Burgos, Rawi Ramautar, Eduard P. A. Van Wijk, Thomas Hankemeier, Jan Van Der Greef

CLINICAL AND FORENSIC APPLICATIONS OF AMBIENT IONIZATION MASS SPECTROMETRY

DEVELOPMENT OF A PAPER SPRAY CARTRIDGE WITH INTEGRATED SPE TO IMPROVE SENSITIVITY FOR DRUG DETECTION...... 310 Chengsen Zhang, Nicholas Manicke

RAPID FINGERPRINTING OF FALSIFIED ANTI-MALARIAL MEDICINES USING AMBIENT PLASMA IONIZATION AND PORTABLE MASS SPECTROMETRY INSTRUMENTATION...... 311 Facundo M. Fernandez, Matthew C. Bernier, Joel D. Keelor, Stephen C. Zambrzycki, Paul N. Newton

TUNABLE IONIZATION AND FRAGMENTATION WITH PLASMA-BASED AMBIENT IONIZATION SOURCES TO EXPAND THEIR UTILITY IN FORENSIC APPLICATIONS...... 312 Jacob Shelley, Sunil Badal, Andrew Schwartz, Garett Maclean, Courtney Walton, Kelsey Williams, Gary Hieftje

IR-MALDESI: AN INNOVATIVE APPROACH TO MOLECULAR IMAGING...... 312 Milad Nazari, Mark Bokhart, David Muddiman

A NEW MATRIX-ASSISTED IONIZATION (MAI) ATMOSPHERIC PRESSURE SAMPLING METHOD POTENTIALLY APPLICABLE FOR CLINICAL AND FORENSIC SAMPLES ...... 313 I-Chung Lu, Milan Pophristic, Charles N. McEwen, Sarah Trimpin

SUSTAINABLE NANOTECHNOLOGY

METHODS FOR VALID SIZING AND QUANTIFICATION OF ENGINEERED NANOPARTICLES IN ENVIRONMENTALLY-RELEVANT WATER MATRICES ...... 314 Brian Mader, Mark Ellefson, Charlie Chan, Christine Loza, Susan Wolf

INSIGHTS INTO NANOPARTICLE INTERACTION WITH CELL SURFACES FROM MODEL SYSTEMS ...... 315 Joel Pedersen, Eric Melby, Thomas Kuech, Arielle Mensch, Julianne Troiano, Arianne Vartanian, Catherine Murphy, Christy Haynes, Franz Geiger, Robert Hamers

USING CROSS-SPECIES COMPARISONS TO CREATE SUSTAINABLE NANOMATERIALS ...... 315 Rebecca Klaper

MICROBIAL ASSAYS FOR FAST, BROAD SCREENING OF ENGINEERED NANOPARTICLE TOXICITY TO BACTERIA ...... 316 Tian Qiu, Joseph Buchman, Thu Nguyen, Hilena Frew, Ariane Vartanian, Lisa Jacob, Xi Zhang, Catherine Murphy, Z. Vivian Feng, Christy Haynes

INVESTIGATION OF BACTERIAL CELL WALL COMPONENTS RESPONSIBLE FOR INTERACTIONS WITH NANOPARTICLES USING B. SUBTILIS MUTANTS...... 317 Vivian Feng

INDUSTRIAL APPLICATIONS OF VIBRATIONAL SPECTROSCOPY

PRODUCT DEVELOPMENT CHALLENGES IN SPECIALTY CHEMICALS ...... 317 Steven Scheifers

MONITOR POLYMERIZATION REACTIONS IN SITU WITH RAMAN SPECTROSCOPY ...... 317 Xiaoyun Chen

QUANTITATIVE NEAR INFRARED CHEMICAL IMAGING OF SOLID MIXTURES ENABLES UNIT PROCESS MASS BALANCE FOR FLOUR MILLING...... 318 Mark Boatwright, David Wetzel

VIBRATIONAL SPECTROSCOPY FOR SILICONE CHEMISTRY ...... 318 Xianghuai Wang, Elmer Lipp

BEST PRACTICES FOR MAINTAINING CALIBRATION MODELS ACROSS MULTIPLE INSTRUMENTS ...... 319 Michael Roberto, Randy Pell, Scott Ramos

LOW FREQUENCY RAMAN, A PHARMACEUTICAL APPROACH

LOW FREQUENCY RAMAN: CONTROLLING THE CRYSTALLIZATION PROCESS...... 319 John Wasylyk, Ming Huang, Robert Wethman

QUANTITATIVE SOLID-STATE ANALYSIS OF AMORPHOUS AND CRYSTALLINE FORMS OF SULFAMERAZINE USING THZ RAMAN SPECTROMETRY...... 320 Joanna Lothian, Alison Nordon, Pol Macfhionnghaile, Keddon Powell, Paul Dallin, John Andrews, James Carriere

APPLYING VIBRATIONAL SPECTROSCOPIES FOR QUANTITATIVE STUDIES OF DRUG RECRYSTALLIZATION IN PHARMACEUTICAL FILMS ...... 320 Yi Li, James K. Drennen III, Carl A. Anderson

REAL-TIME MONITORING OF CRYSTALLINE COMPOUNDS USING IN SITU LOW FREQUENCY RAMAN PROBE ...... 321 Motoki Inoue, Hiroshi Hisada, Tatsuo Koide, Toshiro Fukami

RAMAN SPECTROSCOPY OF LOW ENERGY PHONONS AS A PROBE OF SOLID STATE STRUCTURE OF TRANSITION METAL DICHALCOGENIDE 2D CRYSTALS...... 322 David Tuschel

NANO-IR/NANO-RAMAN-III

TIP-ENHANCED RAMAN IMAGING OF 2D MATERIALS...... 322 Dmitri Voronine

NANOSCALE STUDIES LINK AMYLOID MATURITY WITH POLYGLUTAMINE DISEASES ONSET...... 323 Francesco Simone Ruggeri, Giovanni Dietler, Tuomas Knowles

TERS RESOLUTION POTENTIAL - “CHEMICAL” AND ELECTRO-MAGNETIC CONTRIBUTIONS ...... 324 Volker Deckert, Daniel Kinzel, Stephan Kupfer, Stefanie Gräfe

CHEMISTRY AT THE NANOSCALE: RECENT ADVANCES IN NANOSCALE INFRARED SPECTROSCOPY...... 324 Miriam Unger, Eoghan Dillon, Kevin Kjoller, Anirban Roy, Qichi Hu, Curtis Marcott

ROUND TABLE DISCUSSION ...... 325 Curtis Marcott, Andrew Whitley

RAMAN SPECTROSCOPY FOR SECURITY AND FORENSICS PURPOSES

VIBRATIONAL SPECTROSCOPIC BIOSENSING...... 325 Juergen Popp

A NEW CAPABILITY FOR EXPLOSIVES, NARCOTICS AND HAZARDOUS MATERIALS DETECTION WITHIN SEALED CONTAINERS USING SPATIALLY OFFSET RAMAN SPECTROSCOPY (SORS) ...... 326 Robert Stokes

DEVELOPING DEEP UV RAMAN STANDOFF SPECTROMETERS FOR TRACE EXPLOSIVES...... 327 Sanford Asher, Sergei Bykov, Katie Gares, Kyle Hufziger

AUTOMATIC BODY FLUID DIFFERENTIATION BY RAMAN SPECTROSCOPY AND CHEMOMETRICS ...... 327 Claire Muro, Kyle Doty, Luciana Fernandes, Igor Lednev

SERS SENSING OF PROTEIN TARGETS ENABLED BY POLYMERIC CAPTURE AGENTS...... 328 Victoria Szlag, Matthew Styles, Lindsey Madison, Antonio Campos, Bharat Wagh, Dustin Sprouse, George Shatz, Theresa Reineke, Christy Haynes

FRONTIERS OF FAR-AND DEEP- ULTRAVIOLET SPECTROSCOPY II

GENERATION OF COHERENT VUV PULSES AND ITS APPLICATION TO LASER COOLING OF HYDROGEN ATOMS...... 329 Takamasa Momose

TWO-DIMENSIONAL DEEP-UV STUDIES OF (BIO)CHEMICAL DYNAMICS...... 329 Majed Chergui

ATTENUATED TOTAL REFLECTION FAR-AND DEEP-ULTRAVIOLET SPECTROSCOPY FOR CONDENSED PHASE...... 329 Yukihiro Ozaki

STUDY OF ELECTRONIC STATES OF MOLECULES IN THE CONDENSED PHASE BY USING ATTENUATED TOTAL REFLECTANCE FAR-UV SPECTROSCOPY ...... 330 Yusuke Morisawa

DEEP-UV SURFACE PLASMON FOR BIO-IMAGING...... 330 Yoshimasa Kawata, Masakazu Kikawada, Atsushi Ono, Wataru Ina

ANACHEM AWARD PLENARY

METALLOMEMBRANES: EXPLORING THE INTERACTIONS OF TRANSITION METAL IONS WITH LIPID BILAYERS...... 331 Paul Cremer

APPLIED SPECTROSCOPY WILLIAM F. MEGGERS AWARD PLENARY

PROBING REACTIONS USING TIME-RESOLVED INFRARED SPECTROSCOPY IN SOLUTION AND IN THE SOLID STATE USING QUANTUM CASCADE LASERS...... 331 Mike George, James Calladine, Raphael Horvath, Andrew Davies, Alisdair Wriglesworth, Xue-Zhong Sun

BIOELECTROKINETICS: BIOMOLECULES AND PARTICLES

BIOELECTROKINETICS FOR ADVANCED MANUFACTURING...... 332 Rodrigo Martinez-Duarte

CONTACTLESS DIELECTROPHORESIS FOR THE SEPARATION OF CANCER CELLS AT DIFFERENT STAGES OF PROGRESSION ...... 332 Rafael V Davalos, Temple Douglas, Jaka Cemazar, Eva Schmelz

SINGLE-MICROBIAL MONITORING BY AC ELECTROKINETICS FOR TRACKING THE EMERGENCE OF SUBPOPULATIONS...... 333 Nathan Swami, Yi-Hsuan Su, Ali Rohani, Cirle Warren

MICROFLUIDIC MULTISTAGE INTEGRATION OF IMMUNOASSAY FOR CANCER DIAGNOSIS...... 334 Mei He, Zheng Zhao, Kimberly Plevniak

MATHEMATICAL MODELLING OF THE ELECTROKINETIC BEHAVIOR OF PEGYLATED PROTEINS INSIDE AN INSULATOR-BASED DIELECTROPHORETIC MICRODEVICE...... 334 Roberto C. Gallo-Villanueva, Marco A. Mata-Gomez, Victor H. Perez-Gonzalez, Jose Gonzalez-Valdez, Marco Rito-Palomares, Sergio O. Martinez-Chapa

GLOW DISCHARGE SPECTROSCOPY AND RELATED TECHNIQUES

GUIDING THE DEVELOPMENT OF EFFICIENT AND DURABLE ELECTRODES FOR ELECTROCHEMICAL ENERGY CONVERSION APPLICATIONS THROUGH ADVANCED ION BEAM ANALYSIS...... 335 Jose Miguel Vadillo, John Druce, Tatsumi Ishihara, John Kilner, Helena Tellez

2D MAPPING IN GLOW DISCHARGE MASS SPECTROMETRY...... 336 Piotr Konarski, Maciej Misnik, Aleksander Zawada

INVESTIGATION OF EXCITATION AND IONISATION TEMPERATURES DURING PLASMA START-UP IN GD-OES ...... 336 Arne Bengtson

ELEMENTAL ANALYSIS BY AMBIENT IONIZATION MASS SPECTROMETRY...... 337 Paul Farnsworth, Wade Ellis

CROSS-CORRELATION APPROACH FOR AUTOMATED, HIGH-THROUGHPUT ANALYTE-ION RECOGNITION, CATEGORIZATION AND BACKGROUND REMOVAL FOR DIRECT MASS-SPECTRAL DATA ANALYSIS...... 337 Yi You, Sunil Badal, Jacob Shelley

ANACHEM AWARD SYMPOSIUM HONORING PAUL CREMER

MOBILE, ORIENTED PROTEINACEOUS SUPPORTED BILAYERS MADE DIRECTLY FROM CELL PLASMA MEMBRANES FOR BIOANALYTICAL ASSAYS ...... 338 Susan Daniel

TOWARDS SENSITIVE, SELECTIVE POINT-OF -CARE PLASMONIC DIAGNOSTIC DEVICES...... 339 Laura Sagle, Debrina Jana, Jie He, Ian Bruzas, Sarah Unser

LIPID-PEG-COATED POLYMERIC NANOPARTICLES FOR SYSTEMIC RNAI DELIVERY TO TUMORS...... 340 Jinjun Shi

MECHANO-ANALYTICAL CHEMISTRY ...... 340 Hanbin Mao

PHOSPHATIDYLSERINE-CONTAINING SUPPORTED LIPID BILAYERS AS COPPER-BINDING PROTEIN FILTERS ...... 340 Christopher Monson, Christopher Reynolds

CHEMOMETRIC OPPORTUNITIES IN FORENSIC CHEMISTRY

MULTIVARIATE ANALYSIS OF RAMAN SPECTRAL DATA FOR THE IDENTIFICATION OF BODY FLUID TRACES ...... 341 Igor Lednev, Lenka Halamkova, Kyle Doty, Claire Muro

ANALYSIS AND CHARACTERIZATION OF SMOKELESS POWDERS USING MULTIPLEXED COLLISION-INDUCED DISSOCIATION MASS SPECTROMETRY AND CHEMOMETRIC PROCEDURES ...... 341 Ruth Smith, Kristen L. Reese, A. Daniel Jones

CHEMOMETRIC TOOLS FOR THE INTERPRETATION OF FIRE DEBRIS DATA ...... 342 James Harynuk, Lawrence Adutwum, Robin Abel

FISHER-RATIO ANALYSIS OF GC×GC–TOFMS DATA FOR RELEVANT ANALYTE DISCOVERY ...... 343 Robert Synovec

TO BAYES, OR NOT TO BAYES?...... 343 Stephen L. Morgan

QUANTUM CASCADE LASERS - II

MONOLITHIC QCL SOLUTIONS ENABLING HANDHELD IR SPECTROMETERS...... 344 Christian Pfluegl

CONTACTLESS REAL-TIME IDENTIFICATION OF CHEMICAL SUBSTANCES USING EXTERNAL CAVITY QCLS ...... 344 Marko Haertelt, Jan-Philip Jarvis, Lorenz Butschek, Andre Dreyhaupt, Jan Grahmann, Stefan Hugger, Frank Fuchs, Marcel Rattunde, Ralf Ostendorf, Joachim Wagner

MATCHBOX QCL BASED ANALYZER FOR MULTI-GAS TRACE DETECTION...... 345 Mathieu Carras, Mickael Brun, Fahem Boulila Boulila, Jean Guillaume Coutard, Gregory Maisons

ADVANCES IN LASERDIRECT IR IMAGING...... 345 Charles Hoke, Yuri Beregovski, Andrew Ghetler, Yang Han, Christopher Moon, Richard Tella, Zhen Zhang

RECENT ADVANCES IN RESONANCE ENHANCED AFM-IR SPECTROSCOPY AND IMAGING USING QUANTUM CASCADE LASERS (QCL) ...... 346 Anirban Roy, Eoghan Dillon, Qichi Hu, Kevin Kjoller, Roshan Shetty, Craig Prater

METABOLOMICS

ARE WE DRAWING THE RIGHT CONCLUSIONS FROM METABOLOMICS DATA?...... 346 Coral Barbas, Danuta Dudzick, Joanna Godzien, Emily Hooper, Alma Villaseñor

SHEATHLESS CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY FOR ANIONIC METABOLIC PROFILING...... 347 Rawi Ramautar

METABOLOMIC PROFILING IN PROSTATE CANCER BY HYPHENATED SEPARATION TECHNIQUES AND MASS SPECTROMETRY ...... 348 Michal Markuszewski, Marta Kordalewska, Renata Bujak, Tomáš Kovalczuk, Agnieszka Ulanowska

ELECTROEXTRACTION STRATEGIES FOR ENRICHMENT OF LOW-ABUNDANT METABOLITES...... 349 Peter Lindenburg, Amar Oedit, Thomas Hankemeier

DNA SEQUENCING AND ELECTROPHORESIS

POLYMER-BASED NANOSENSORS USING NANOSCALE ELECTROPHORESIS OF MONONUCLEOTIDES FOR SINGLE-MOLECULE SEQUENCING ...... 350 Steven Soper

UNFOLDING OF NANOCHANNEL CONFINED DNA FOR GENOMIC MAPPING...... 350 Kevin Dorfman, Jeffery Reifenberger, Han Cao

MONITORING CELLULAR RELEASE OF CHEMICAL MESSENGERS USING IN VITRO MICRODIALYSIS COUPLED WITH HIGH-SPEED CAPILLARY ELECTROPHORESIS ...... 351 Michael Bowser, Amy Stading, Rachel Harstad

µLAS, A TECHNOLOGICAL BREAKTHROUGH TO PERFORM QUANTIFICATION AND SIZE ANALYSIS OF PLASMATIC CIRCULATING DNA WITHOUT PRIOR PURIFICATION ...... 352 Audrey Boutonnet, Comtet-Louis Andriamanampisoa, Aurélien Bancaud, Jacques Favre, Frédéric Ginot, Arnaud Morin, Vincent Picot, Laure Saias

HIGH-SENSITIVITY MASS SPECTROMETRY FOR BASIC AND TRANSLATIONAL RESEARCH

EXPLORING THE PROTEOME OF COLORECTAL CANCER BY MASS SPECTROMETRY ...... 353 Amanda Hummon

MASS SPECTROMETRY-BASED ANALYSIS IN GENETIC DISORDERS RELATED TO CHOLESTEROL HOMEOSTASIS...... 353 Stephanie M. Cologna

CELL-BY-CELL ANALYSIS OF PROTEIN EXPRESSION IN THE FROG (XENOPUS LAEVIS) EMBRYO BY CE-µESI-HRMS ...... 354 Camille Lombard-Banek, Sally A. Moody, Peter Nemes

SENSITIVITY VS. MOLECULAR COVERAGE IN NON-TARGETED ANALYSIS OF COMPLEX SAMPLES...... 355 Akos Vertes

MASS SPECTROMETRY PROFILING OF LIVE 3D ARTIFICIAL TUMORS USING THE SINGLE-PROBE DEVICE...... 356 Wei Rao, Ning Pan, Xiang Tian, Zhibo Yang

BIOTEMPLATE-BASED NANOMATERIALS FOR ENERGY APPLICATIONS

NEW PHOTONIC MATERIALS TEMPLATED WITH CELLULOSE NANOCRYSTALS ...... 356 Mark Maclachlan

STIMULI RESPONSIVE AND RECONFIGURABLE NOBLE METAL NANOPARTICLE BIOINTERFACES ...... 357 Marc Knecht

BIOTEMPLATED PZT NANOWIRES AND 3D PRINTING FUNCTIONAL DEVICES ...... 357 Michael McAlpine

VERTICALLY ALIGNED PIEZOELECTRIC DIPHENYLALANINE PEPTIDE MICRORODS FOR ENERGY HARVESTING ...... 358 Rusen Yang, Vu Nguyen, Ren Zhu, Kory Jenkins

ONLINE ANLAYSIS OF INDUSTRIAL PROCESSES AND REACTIONS

ONLINE ANALYSIS USING VACUUM ULTRAVIOLET ABSORPTION SPECTROSCOPY ...... 358 Dale Harrison, Phillip Walsh, Jonathan Smuts, James Diekmann

APPLICATION OF ON-LINE PROCESS MASS SPECTROMETRY IN R&D ...... 359 Eric Schmidt, Derrick Flick, Liwei Li, Yujun Liu

RUGGED IN-PROCESS FTIR USING AN ENHANCED SAGNAC INTERFEROMETER...... 359 Dan Wood

HARD, SOFT, AND CIRCUMSTANTIAL CORRELATIONS: THINKING CHEMICALLY ABOUT MOTOR FUEL PROPERTY PREDICTIONS BY MULTIVARIATE SPECTROMETRY ...... 360 Marcus Trygstad, Bradford Behr, Jeremy Linoski

ANALYSIS OF SULFUR AND OXYGENATE SPECIES IN HYDROCARBON PROCESS STREAMS USING A NOVEL BALLISTIC GC-HPMS...... 361 Graham Shelver

STANDOFF RAMAN SPECTROSCOPY: INSTRUMENTATION AND APPLICATIONS

ADVANCEMENTS IN RAMAN SPECTROSCOPY FOR MILITARY APPLICATIONS & FORENSIC ATTRIBUTION...... 361 Augustus Fountain

SCANNING STANDOFF RAMAN INSTRUMENTS FOR LARGE AREA HAZARDOUS CHEMICAL DETECTION ...... 362 Shiv Sharma, Anupam Misra, Tayro Acosta-Maeda, John Porter

STANDOFF HYPERSPECTRAL RAMAN SENSORS FOR THE DETECTION OF EXPLOSIVES ...... 362 Nathaniel Gomer, Charles Gardner, Matthew Nelson

ADVANCES IN DEEP-ULTRAVIOLET (DUV) RAMAN SPECTROSCOPY FOR THE STANDOFF DETECTION OF THREAT MATERIALS...... 363 Luisa T. M. Profeta, Adam J. Hopkins, Kenneth R. Pohl, Kenneth R. Pohl

RAMAN SPECTROSCOPY OF VAPOR AND AEROSOL CHEMICAL WARFARE AGENTS ...... 364 Erik Emmons, Francis D’Amico, Gary Kilper, Steven Christesen, Aime Goad, David Sickenberger

THE POWER OF MANY: SUPPORTING DIVERSITY IN ANALYTICAL CHEMISTRY

ADVANCING DIVERSITY IN STEM FIELDS: STRATEGIES AND REFLECTIONS ...... 364 Colin Ingram

GENDER DISPARITY IN SCHOLARLY PUBLISHING ...... 365 Kristin Selinder Macdonald

PREPARING STUDENTS WITH DISABILITIES FOR GRADUATE SCHOOL: THOUGHTS AND EXPERIENCES...... 365 Karl Booksh, Sharon Rozovsky, Joseph Smith

DIVERSITY AND INCLUSION IN ACADEMIA ...... 366 Atcha Totachawattana

NAVIGATING LGBT DISPARITIES IN AN INDUSTRIAL WORKPLACE...... 366 Blake Bailes

SURFACE ANALYSIS OF BIOMATERIALS AND BIOLOGICAL MATERIALS

WHAT IT IS AND WHERE IT IS– SUPER-RESOLUTION MASS SPECTROMETRY IMAGING OF BIOMATERIALS WITH THE NEW 3D NANOSIMS ...... 366 Ian Gilmore

SINGLE CELL RAMAN SPECTROSCOPY FOR UNDERSTANDING FREEZING DAMAGE ...... 367 Allison Hubel, Guanglin Yu

CHARACTERIZATION OF SURFACES AND INTERFACES IN THE MEDICAL DEVICE INDUSTRY...... 368 Bill Theilacker, Anna Belu, Tony Anderson

IN SITU CHEMICAL IMAGING OF BIOINTERFACES USING MICROFLUIDICS ...... 368 Xiao-Ying Yu

WEDNESDAY POSTERS - CHEMOMETRICS

PENALIZED EIGENDECOMPOSITIONS: MOTIVATIONS FROM DOMAIN ADAPTATION FOR CALIBRATION TRANSFER AND MAINTENANCE...... 369 Erik Andries

AUTOMATED CHEMICAL IMAGING ANALYSIS FOR THE IDENTIFICATION OF DRUGS AT CORRECTIONAL FACILITIES...... 370 Robert Schweitzer, Patrick Treado, Nate Gomer, Oksana Olkhovyk

MODELING AND PERFORMANCE EVALUATION OF CONFORMAL FILTER (CF) REAL-TIME STANDOFF HAZARDOUS MATERIALS DETECTION ...... 370 Arjun Bangalore, Mathew Nelson, George Ventouris, Patrick Treado

A CASE STUDY ON NIR ONLINE MONITORING OF BLEND UNIFORMITY IN SOLID DOSAGE FORM...... 371 Jin Zhang, Dimuthu Jayawickrama, Tim Stevens, Jay Poorna Reddy, Judy Lin, Robert Garmise

REDUCING SPECTRAL ANALYTE PREDICTION ERROR WITH PENALTIES ON INTERFERENTS...... 371 William Spence, John Kalivas

AN ENSEMBLE OF MULTIPLE LINEAR REGRESSION MODELS FOR EASY WAVELENGTH SELECTION...... 372 Tony Lemos, John Kalivas

REGULARIZATION ADAPTION PROCESSES WITH LABELED AND UNLABELED DATA FOR MULTIVARIATE CALIBRATION MAINTENANCE ...... 372 Anit Gurung, John H. Kalivas, Erik Andries

EFFECT OF EXPERIMENTAL DESIGN AND CALIBRATION STRUCTURE ON THE PREDICTION PERFORMANCE OF A NEAR INFRARED CALIBRATION MODEL...... 373 Md Anik Alam, Md Nayeem Hossain, Douglas Steinbach, James Drennen III, Carl Anderson

ROBUST LATENT VARIABLE SELECTION FOR MULTIPLE INSTRUMENT CALIBRATION APPLICATIONS...... 373 Douglas Steinbach, Anik Alam, Nayeem Hossain, Carl Anderson, James K Drennen

WEDNESDAY POSTERS – MOLECULAR SPECTROMETRY – IR, NEAR IR, 2D CORRELATION, IMAGING

IMPROVEMENT OF SIGNAL-TO-NOISE LEVEL IN 2D ASYNCHRONOUS SPECTRA BY USING WAVELET TRANSFORMATION APPROACHES...... 374 Yizhuang Xu, Anqi He, Xiaoyan Kang, Jing Chen, Yanjun Zhai, Isao Noda, Jinguang Wu

INVESTIGATION ON INTERMOLECULAR INTERACTION BETWEEN BERBERINE HYDROCHLORIDE AND ?-CYCLODEXTRIN BY USING 2D ASYNCHRONOUS SPECTRA ...... 375 Yizhuang Xu, Xiaoyan Kang, Anqi He, Jing Chen, Yanjun Zhai, Isao Noda, Jinguang Wu

APPLICATION OF NEAR-INFRARED SPECTROSCOPY FOR IN-PROCESS MONITORING IN PHARMACEUTICAL DEVELOPMENT ...... 375 Ming Huang, Robert Wethman, John Wasylyk

GAS AND VAPOR DETECTION BY FIBER-COUPLED TUNABLE LASER DIODE ABSORPTION SPECTROSCOPY...... 376 Allan Chang, Eric Avalos, Michael Pocha, William Benett, Mihail Bora, Michael Emmons, Tiziana Bond

FOCAL PLANE ARRAY CHEMICAL IMAGING OF HETEROGENEOUS ORGANIC MIXTURES ENABLES DIRECT QUANTITATIVE ANALYSIS...... 376 Mark Boatwright, David Wetzel

REAL TIME MONITORING IN CATHODE MATERIAL OF LI-ION BATTERY DURING ELECTROCHEMICAL PERFORMANCE USING RAMAN SPECTROSCOPY ...... 377 Yeonju Park, Yeseul Kim, Yujing Chen, Young Mee Jung

STUDIES OF FERTILIZED FISH EGGS DEVELOPMENT BY USING NEAR-INFRARED SPECTROSCOPY AND IMAGING...... 378 Paralee Puangchit, Mika Ishigaki, Yasui Yui, Yukihiro Ozaki

NEAR INFRARED SPECTROSCOPY FOR MEASURING MOISTURE LEVELS IN SOLVENTS AND MONOMERS...... 379 Caleb Brian

REAL-TIME COMPOSITION OF LIQUID AND GAS PHASE HYDROCARBONS WITH A MEMS WIDELY TUNABLE LASER BASED NEAR INFRARED SPECTROMETER ...... 379 Steven Minehhan, Paul Little

IN VIVO MONITORING FOR GROWTH AND ABNORMALITY OF FISH EGG BY NEAR-INFRARED SPECTROSCOPY AND IMAGING...... 380 Yui Yasui, Mika Ishigaki, Paralee Puangchit, Yukihiro Ozaki

WEDNESDAY POSTERS – MASS SPECTROMETRY

NEAR-FIELD LASER ABLATION SAMPLING FOR PROTEOMICS AND GENOMICS ...... 380 Kermit Murray, Fan Cao, Fabrizio Donnarumma

MALDI-TOFMS DETERMINATION OF COPPER AND MERCURY IN FOOD RELATED MATRICES USING BI(III) AS INTERNAL STANDARD AND SODIUM DIETHYLDITHIOCARBAMATE FOR COMPLEXATION...... 381 Manuel Méndez García, Kazimierz Wrobel, Armando Alcázar Magaña, Alma Rosa Corrales Escobosa, Francisco Javier Acevedo Aguilar, Katarzyna Wrobel

METABOLITE PROFILING IN HELIANTHUS ANNUUS HYDROPONICALLY GROWN UNDER EXPOSURE TO CR(VI)...... 382 Alan Alexander González Ibarra, Katarzyna Wrobel, Alma Rosa Corrales Escobosa, Félix Gutiérrez Corona, Víctor Manuel Mondragón Olguín, Kazimierz Wrobel

METABOLOMICS OF HEPATOCYTES AND HUMAN SERUM BY LASER DESORPTION IONIZATION MASS SPECTROMETRY FROM SILICON NANOPOST ARRAYS ...... 383 Andrew Korte, Akos Vertes

TRANSPORTABLE LINEAR ION TRAP MASS SPECTROMETER WITH CONTINUOUS ATMOSPHERIC PRESSURE INLET...... 384 Yang Cui, Michael Volny, Lynn Chandler, William Yang

ANALYTICAL-TOOL FOR THE AUTOMATIC DETERMINATION OF TRACE METALS CONTAINED IN ORGANIC MEDIA: COUPLING OF IN-SYRINGE MAGNETIC STIRRING-ASSISTED LIQUID-LIQUID MICROEXTRACTION TO ICP-OES TOTAL SAMPLE CONSUMPTION...... 385 José Luis Todolí, Raquel Sánchez, Burkhard Horstkotte, Salvador Maestre, Manuel Miró

COMPARISON OF HIGH RESOLUTION QUADRUPOLE-TIME-OF-FLIGHT AND ORBITRAP MASS SPECTROMETERS FOR THE ANALYSIS OF SMALL HYDROPHOBIC MOLECULES...... 385 Marzieh Ramezani, Lee Parsons, Edgar Arriaga

COMPARISON OF DISSOCIATION CHARACTERISTICS OF OLIGOSACCHARIDES AND GLYCOCONJUGATES VIA COLLISION-INDUCED DISSOCIATION AND SURFACE-INDUCED DISSOCIATION...... 386 Forouzan Aboufazeli, Eric D. Dodds

SINGLE CELL ELEMENTAL ANALYSIS OF HUMAN CELLS USING DROPLET INJECTION ICP-AES/MS ...... 388 Shunsuke Hosoda, Satoshi Kohno, Aida Mari, Ken Kakegawa, Tomoko Miyake, Takahiro Iwai, Hidekazu Miyahara, Mikio Shimada, Yoshihisa Matsumoto, Akitoshi Okino

WEDNESDAY POSTERS - NANOTECHNOLOGY

OLIGONUCLEOTIDE MODIFIED NANOPARTICLES FOR HARMFUL ALGAL BLOOM DETECTION...... 388 Claire Lenehan, Karen Bruce, Amanda Ellis, Sophie Leterme

ENHANCED FERROMAGNETISM IN NANOSCALE TRANSITION METAL-DOPED TIO2 ...... 389 Swati Naik

ONE-POT GROWTH OF 3D REDUCED GRAPHENE OXIDE FOAMS EMBEDDED WITH NIFE OXIDE NANOCATALYSTS FOR OXYGEN EVOLUTION REACTION...... 389 Daoyuan Wang, Wei Zhao

LASER INDUCED FLUORESCENCE SYSTEM WITH ERROR COMPENSATOR FOR SANDWICH-TYPE IMMUNOASSAY USING NANOPARTICLES ...... 390 Heung Bin Lim, Yeunghyun Kim

ENVIRONMENTAL TOXICITY ASSESSMENT OF INDUSTRIALLY RELEVANT NANOMATERIALS USING BACTERIA MODEL ...... 390 Sunipa Pramanik, Jeslin Wu, Shreyashi Ganguly, Bryce Williams, Eray Aydil, Uwe Kortshagen, Christy Haynes

NOVEL TRIS(2-AMINOETHYL)AMINE FUNCTIONALIZED MAGNETIC IRON OXIDE NANOPARTICLES FOR CURCUMIN DELIVERY...... 391 Emily Czapiewski, Anselm Omoike

WEDNESDAY POSTERS – RAMAN – SERS/TERS

NEW DIRECTIONS IN ULTRAHIGH VACUUM TIP-ENHANCED RAMAN SPECTROSCOPY WITH MOLECULAR-RESOLUTION SCANNING TUNNELING MICROSCOPY ...... 392 Philip Whiteman, Zachary Porach, Nan Jiang

EFFECT OF SUBSTITUENTS ON SURFACE EQUILIBRIA OF THIOPHENOLS AND ISOQUINOLINES ON GOLD SUBSTRATES STUDIED USING SURFACE-ENHANCED RAMAN SPECTROSCOPY...... 392 Erik Emmons, Ashish Tripathi, Augustus Fountain III, Steven Christesen, Jason Guicheteau

VIBRATIONAL NANOSCOPY WITH ULTRAHIGH VACUUM TIP-ENHANCED RAMAN SPECTROSCOPY (UHV-TERS)...... 393 Naihao Chiang, Guillaume Goubert, Eric A. Pozzi, Nan Jiang, Tamar Seideman, Mark C. Hersam, Richard P. Van Duyne

DEVELOPMENT OF PLASMONIC PLATFORMS FOR MULTISPECTRAL SURFACE-ENHANCED SPECTROSCOPIES...... 393 Gregory Wallace, Mohammadali Tabatabaei, Renjie Hou, Matthew Coady, Peter Norton, Todd Simpson, Scott Rosendahl, Alexandre Merlen, François Lagugné-Labarthet

USING STARK SHIFTS TO UNDERSTAND THE DRIVING FORCES IN PLASMONIC CATALYSIS ...... 394 Darby Nelson, Zachary Schultz

SINGLE MOLECULE SURFACE-ENHANCED RAMAN SPECTROSCOPY: TOWARDS RELIABLE PROOF METHODOLOGY AND NONRESONANT DETECTION...... 394 Nolan Wong, Alyssa Zrimsek, Richard Van Duyne

GRAPHENE-PLASMONIC HYBRID NANOCOMPOSITE FOR SURFACE ENHANCED RAMAN SCATTERING (SERS) APTASENSING ...... 395 Ahmed Mahmoud, Mark McDermott

TIP-ENHANCED RAMAN SPECTROSCOPY FOR STUDYING SINGLE-MOLECULE ELECTROCHEMISTRY...... 396 Michael Mattei, Xu Chen, Gyeongwon Kang, Guillaume Goubert, Richard P. Van Duyne

INVESTIGATING SINGLE, HETEROGENEOUS ONE-ELECTRON TRANSFER REACTIONS WITH EC- SERS ...... 396 M. Fernanda Cardinal, Zaleski Stephanie, Chulhai Dhabih, Jordan M. Klingsporn, Lasse Jensen, Richard P. Van Duyne

PLASMON-DRIVEN HOT ELECTRON CHEMISTRY IN ISOTOPICALLY EDITED 4,4’-BIPYRIDINE GOLD NANOANTENNAS ...... 397 Emily Sprague-Klein, Michael McAnally, Dmitry Zhdanov, Alyssa Zrimsek, Vartkess Apkarian, George Schatz, Tamar Seideman, Richard Van Duyne

WEDNESDAY POSTERS – SURFACE PLASMON RESONANCE AND SURFACE SCIENCE

NANOPARTICLE ENHANCED SPRI AS A DIAGNOSTIC PLATFORM FOR THE EARLY DETECTION OF ACUTE KIDNEY INJURY...... 397 Kristy S. McKeating, Samuel S. Hinman, Siqi Li, Zhiguo Zhou, Quan Cheng

INVESTIGATION OF FAR-AND DEEP-ULTRAVIOLET SURFACE PLASMON RESONANCE DEPENDING ON REFRACTIVE INDIES AND ABSORBANCE ON AL FILM...... 398 Koji Watari, Ichiro Tanabe, Yoshito Tanaka, Takeyoshi Goto, Wataru Inami, Yoshimasa Kawata, Yukihiro Ozaki

BIOCONJUGATION STRATEGY TO INCREASE STABILITY OF PROTEIN MODIFIED GOLD NANOPARTICLES FOR USE IN LIGHT SCATTERING IMMUNOASSAYS...... 399 Seth Filbrun, Alex Mandl, Kirk Eichenberg, Francis Lovato, Jeremy Driskell

STORING MATTER TECHNIQUE IN SECONDARY ION MASS SPECTROMETRY: APPLICATION FOR DEPTH PROFILING...... 400 Maciej Misnik, Aleksander Zawada, Piotr Konarski

PLASMONIC GRADED GRATINGS FOR HYPERSPECTRAL - INFRARED SENSING AND IMAGING ...... 401 Arthur Montazeri, Hoi-Ying Holman

RSC-ACS SYMPOSIUM – SOLVING GLOBAL HEALTH CHALLENGES: MOLECULAR TECHNIQUES TOWARDS DIAGNOSTICS AND DETECTION

ELECTROCHEMICAL INSIGHTS INTO NEURODEGENERATIVE DISEASES: USING DROSOPHILA MODELS TO UNDERSTAND PARKINSON DISEASE ...... 402 B. Jill Venton, Eve Privman, Ryan Borman, Poojan Pyakurel, Danielle Wolin, Leah Ostendorf, Subrahata Sanyal, Nathan Dolenson

MULTIPLEXED, PHOTONIC SENSOR ARRAYS FOR INFORMATIVE DISEASE DIAGNOSIS ...... 402 Ryan Bailey

DOES RAMAN SPECTROSCOPY OFFERS A SOLUTION TO CURRENTLY UNMET MEDICAL NEEDS!? ...... 403 Juergen Popp

DETECTION AND DIAGNOSIS OF MALIGNANCIES USING RAMAN SPECTROSCOPIC TECHNIQUES...... 404 Nick Stone

LABEL-FREE DIAGNOSIS AND DETECTION USING MOLECULAR VIBRATIONAL FINGERPRINTS...... 404 Ji-Xin Cheng

MICRO- AND NANOFLUIDICS FOR PREPARATION, SEPARATION AND DETECTION OF BIOMOLECULES AND CELLS

MICROSCALE ANALYSIS OF HETEROGENEOUS CIRCULATING TUMOR CELLS...... 405 Reza Mohamadi, Shana Kelley

LABEL-FREE ELECTRICAL DETECTION OF ENZYMATIC REACTIONS IN 2-D NANOCHANNELS...... 405 Chuanhua Duan

SINGLE CELL AND SINGLE MOLECULE ANALYTICAL DEVICES UTILIZING NANOFLUIDIC TECHNOLOGY ...... 406 Kazuma Mawatari, Takehiko Kitamori

MICROFLUIDIC PLATFORM FOR BILAYER EXPERIMENTATION ...... 406 Séverine Le Gac

ELECTRICAL DETECTION AND DISCRIMINATION OF BACTERIA AND CELLS IN MICROFLUIDIC DEVICES ...... 407 Noritada Kaji, Hirotoshi Yasaki, Mamiko Sano, Takao Yasui, Yoshinobu Baba

ICPMS: FUNDAMENTALS AND APPLICATIONS

HIGH-PRECISION ISOTOPIC ANALYSIS OF ESSENTIAL TRANSITION METALS IN HUMAN BODY FLUIDS FOR MEDICAL DIAGNOSIS, PROGNOSIS & MONITORING...... 408 Frank Vanhaecke, Yulia Anoshkina, Marta Costas-Rodriguez, Maria Del Rosario Florez, Sara Lauwens, Hans Van Vlierberghe, Marijn Speeckaert, Joris Delanghe

ASYMMETRICAL FLOW FIELD-FLOW FRACTIONATION COUPLED TO INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY FOR ASSESSMENT OF THE QUALITY OF FUNCTIONALIZED QUANTUM DOTS ...... 409 Jose Manuel Costa-Fernandez, Diego Bouzas Ramos, Mario Menendez Miranda, Jorge Ruiz Encinar, Alfredo Sanz-Medel

ANALYSIS OF WHOLE BLOOD THROUGH ICP-MS EQUIPPED WITH A HIGH TEMPERATURE TOTAL SAMPLE CONSUMPTION SYSTEM ...... 410 José-Luis Todolí, Águeda Cañabate, Esperanza García-Ruiz, Martín Resano

MONITORING OF MOLECULAR SPECIES FOR ELEMENTAL AND ISOTOPIC ANALYSIS...... 411 Martin Resano, Esperanza García-Ruiz, Maite Aramendía, Ananda Guarda, Diego Leite

NANOPARTICLE DETECTION IN ENVIRONMENTALLY RELEVANT MATRICES USING DIFFERENTIAL MOBILITY ANALYSIS-INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY ...... 412 Qilin Chan, Mark Ellefson, Christine Loza, Brian Mader, Susan Wolf

MEGGERS AWARD SYMPOSIUM HONORING MIKE GEORGE

TRANSIENT RAMAN SPECTROSCOPY OF RUTHENIUM(II) COMPLEXES WITH ELECTRON DONOR LIGANDS...... 412 Keith Gordon, Georgina Shillito

TIME-RESOLVED VIBRATIONAL SPECTROSCOPY OF PHOTOEXCITED STATES ...... 413 Terry Gustafson

WHAT WE SEE BY TIME-RESOLVING IN NEAR-IR ...... 413 Koichi Iwata

MECHANISTIC STUDIES INTO THE LIGHT DRIVEN PRODUCTION OF H2 FROM A BIOMIMETIC OF THE ACTIVE SITE OF [NIFE] HYDROGENASE ...... 414 Peter Summers, James Calladine, Fabio Ghiotto, Jonathan McMaster, Martin Schröder, Michael George

SLOW TIME-RESOLVED MEASUREMENTS RAMAN MEASUREMENTS IN INDUSTRY...... 414 Paul Pudney

CLIRSPEC BIOMEDICAL APPLICATIONS OF NEAR-FIELD INFRARED SPECTROSCOPY

PLASMON-ASSISTED INFRARED-STRUCTURED ILLUMINATION MICROSCOPY OF LIVING CELLS...... 415 Liang Chen, Hoi-Ying Holman, Arthur Montazeri, Giuseppe Calafiore, Giovanni Birarda, Alexksandr Polyakov, Nazir Kherani, Stefano Cabrini

AFM-IR TECHNIQUE: A NEW OUTLOOK FOR BIOMEDICAL STUDIES...... 416 Alexandre Dazzi, Jérémie Mathurin, Ariane Deniset-Besseau

SYNCHROTRON IR NANOSPECTROSCOPY AT DIAMOND LIGHT SOURCE ...... 416 Chris Kelley, Paul Donaldson, Jacob Filik, Mark Frogley, Ann Fitzpatrick, Katia Wehbe, Gianfelice Cinque

CONTACT RESONANCE DRIFTS IN PTIR? SOLVED...... 417 Georg Ramer, Florian Reisenbauer, Anna Balbekova, Andreas Schwaighofer, Bernhard Lendl

NANOSCALE INFRARED SPECTROSCOPY AND IMAGING OF CONTROL AND OVERLOAD-DAMAGED TENDON ...... 418 Kathleen Gough, Richard Wiens, Catherine Findlay, Daisy Ma, Samuel Baldwin, Laurent Kreplak

CLIRSPEC: CLINICAL APPLICATIONS OF IR SPECTROSCOPY AND IMAGING

EXPLORING BREAST CANCER PROGNOSIS SPECIFIC TISSUE MICROENVIRONMENT CHANGES THROUGH INFRARED SPECTROSCOPY ...... 419 Saumya Tiwari, Sarah Holton, Tiziana Triulzi, Elda Tagliabue

FOURIER TRANSFORM INFRARED (FTIR) SPECTROSCOPIC IMAGING DRIVEN HISTOPATHOLOGICAL ASSESSMENT OF EPITHELIAL MISPLACEMENT VERSUS POLYP CANCER IN THE COLON ...... 420 Jayakrupakar Nallala, Rebecca Griggs, Gavin Lloyd, Timothy Cook, Catherine Kendall, Hugh Barr, Neil Shepherd, Nick Stone

VIBRATIONAL SPECTROSCOPY IN THE MANAGEMENT OF CANCER. AREN’T WE THERE YET? ...... 421 Abigail Rutter, Josep Sulé-Suso

CHEMICAL IMAGING OF AMYLOID-ß PLAQUES ...... 421 Francesca Palombo, Francesco Tamagnini

DETECTING BIOCHEMICAL CHANGES IN LIVER FIBROSIS USING QUANTUM CASCADE LASER INFRARED SPECTROSCOPIC IMAGING...... 422 Michael Walsh, Vishal Varma, Hari Sreedhar, Grace Guzman

ITP CLOSING KEYNOTE LECTURES I

ANALYSIS OF DRUG-PROTEIN INTERACTIONS USING HIGH-PERFORMANCE AFFINITY MICROCOLUMNS: RECENT DEVELOPMENTS FOR CLINICAL SAMPLES AND PERSONALIZED MEDICINE ...... 422 David Hage

PARTIALLY FILLING AFFINITY CAPILLARY ELECTROPHORESIS - COMPLEMENTARY OR ALTERNATIVE TECHNIQUE FOR BIOSENSORS IN BIOMOLECULAR INTERACTION STUDIES?...... 423 Marja-Liisa Riekkola, Joanna Witos, Katriina Lipponen, Jörgen Samuelsson, Torgny Fornstedt, Katariina Öörni, Matti Jauhiainen

AFFINITY CAPILLARY ELECTROPHORESIS: A VALUABLE CONTRIBUTION TO LIGAND BINDING ASSAY PLATFORMS...... 424 Hermann Wätzig, Imke Oltmann-Norden, Mona Mozafari, Hassan Alhazmi, Markus Nachbar, Deia Abd El-Hady, Sami El Deeb

GLYCOHISTOPATHOLOGY OF FORMALIN FIXED – PARAFFIN EMBEDDED (FFPE) SAMPLES...... 424 Andras Guttman, Boglarka Donczo , Marton Szigeti , Bryan Fonslow

ITP CLOSING KEYNOTES LECTURES II

MONOLITHIC COLUMNS WITH INCORPORATED BARE AND SURFACE BONDED SILICA NANOPARTICLES FOR HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY ...... 425 Ziad El Rassi, Nisansala Ganewatta

NANOBIODEVICE-BASED SEPARATIONS OF SINGLE BIOMOLECULE, EXOSOME, AND CELL FOR MEDICAL INNOVATIONS...... 426 Yoshinobu Baba

OUR RECENT STUDIES ON ENANTIOMER SEPARATION MECHANISMS IN CAPILLARY ELECTROPHORESIS ...... 427 Bezhan Chankvetadze

HILIC-MS OF INTACT GLYCOPROTEINS ...... 427 Govert W. Somsen, Elena Dominguez Vega, Jordy Van Angeren, Klara Petru, Sara Tengattini, Rob Haselberg

ITP CLOSING PLENARY AND CLOSING REMARKS

PRACTICE AND RAMIFICATIONS OF ULTRA FAST CHIRAL AND CHIRAL SEPARATIONS...... 428 Daniel Armstrong

FUNDAMENTALS OF LIBS FOR ENHANCED ANALYTICAL PERFORMANCE

FEMTOSECOND FILAMENTS IN REMOTE ISOTOPE ANALYSIS...... 428 Vassilia Zorba, George C.-Y. Chan, Huaming Hou, Xianglei Mao, Richard Russo

REAL TIME ISOMER FINGERPRINTING WITH LIBS ...... 429 Ishan Barman

ELEMENTAL IMAGING BY LIBS: PRESENT AND POTENTIAL FUTURE...... 429 Vincent Motto-Ros, Frédéric Pelascini

NANOPARTICLE ENHANCED LASER INDUCED BREAKDOWN SPECTROSCOPY APPLICATIONS ...... 430 Alessandro De Giacomo, Marcella Dell, Rosalba Gaudiuso, Can Koral, Gabriele Valenza

MODELING AND DIAGNOSTICS OF MOLECULES IN LASER INDUCED PLASMA ...... 430 Igor Gornushkin, Sergei Shabanov, Reto Glaus, Ulrich Panne

ADVANCES IN ON-LINE PROCESS ANALYSIS

TOWARDS HYPERPOLARISED BENCHTOP NMR SPECTROSCOPY FOR INDUSTRIAL PROCESS MONITORING AND CONTROL ...... 431 Meghan Halse, Simon Duckett, Alison Nordon, Andrew Parrott, Peter Richardson, Olga Semenova

X-RAY IMAGING FOR DESIGN OF GAS NOZZLES IN LARGE SCALE FLUIDISED BED REACTORS ...... 432 Massimiliano Materazzi, Paola Lettieri, Jonathan Dodds, Andrew Milliken

THE MONITORING OF SECONDARY PROCESSES USING PROCESS ANALYTICAL TECHNOLOGIES...... 432 Joanna Lothian, Alison Nordon, Peter Hamilton, Richard Elkes

ONLINE LC/MS MONITORING OF A CONTINUOUS PROCESS WITH A PORTABLE SINGLE- QUADRUPOLE MASS SPECTROMETER: LOW LEVEL IMPURITY MONITORING AND IMPURITY IDENTIFICATION...... 433 Bradley Campbell, Mindy Forst, Todd Maloney

LIFECYCLE MANAGEMENT OF RAMAN SPECTROSCOPY OF THE ACTIVE CONTENT OF AN ORAL DOSAGE FORM ...... 433 Md Nayeem Hossain, Benoît Igne, Md Anik Alam, Carl Anderson, James Drennen

NOVEL APPROACHES TO BIOPHARMACEUTICAL ANALYSIS

PROBING HIGHER-ORDER STRUCTURE IN BIOPHARMACEUTICALS USING RAMAN AND RAMAN OPTICAL ACTIVITY...... 434 Laurence Nafie, Rina Dukor, Carolina Carballo, Juanita Sanchez

SPECTROSCOPIC CHARACTERIZATION OF PROTEIN-BASED PHARMACEUTICALS...... 435 John Wasylyk, Rose Soskind, Michaella Raglione, Mary Krause, Daniel Faschana

CHEMICALLY MODIFIED OLIGONUCLEOTIDES TARGET THE SERCA/PLN COMPLEX...... 435 Kailey J. Soller, Jing Yang, Raffaello Verardi, Gianluigi Veglia, Michael Bowser

A MULTISCALE ANALYSIS OF THE MECHANICAL PROPERTIES OF THE FIBROUS PROTEINS OF THE EXTRACELLULAR MATRIX USING BRILLOUIN LIGHT SCATTERING SPECTROSCOPY...... 436 Ryan Edginton, Francesca Palombo, Ellen Green, C. Peter Winlove

MOLECULAR STRUCTURE AND THERMAL BEHAVIOR OF BIODEGRADABLE POLY(3- HYDROXYBUTYRATE- CO-3-HYDROXYHEXANOATE) /POLYETHYLENE GLYCOL BLENDS ...... 437 Yujing Chen, Yeonju Park, Isao Noda, Young Mee Jung

RAMAN SPECTROSCOPIC SENSING

ULTRASOUND ENHANCED IN-LINE RAMAN SENSING OF PARTICLES IN SUSPENSIONS ...... 438 Bernhard Lendl, Stefan Radel, Stefan Tauber

BIO-SENSING WITH SURFACE ENHANCED RAMAN AND HYPER-RAMAN SCATTERING ...... 438 Janina Kneipp, Daniela Drescher, Zsuzsanna Heiner, Tina Büchner, Marina Gühlke, Fani Madzharova

RAMAN SPECTROSCOPY WITH BROADBAND LIGHT SOURCES ...... 439 Johannes Kiefer

RAMAN SPECTROSCOPY OF CELLULAR DEFENCE RESPONSES ...... 439 Alison J. Hobro, Nicholas I. Smith

FIBER AND CAVITY BASED RAMAN SENSING...... 440 Torsten Frosch, Di Yan, Tobias Jochum, Jürgen Popp

RAMAN CONTRIBUTED SESSION

EVALUATION OF SPECIALIZED VIBRATIONAL SPECTROSCOPIC TECHNIQUES FOR CHIRAL PURITY ANALYSIS ...... 440 Sergey Arzhantsev

APPLICATION OF BACK-SCATTER RAMAN SPECTROSCOPY TO FLUIDIZED BED COATING PROCESS...... 441 Hanzhou Feng, James Drennen, Carl Anderson

A COMPARATIVE STUDY BETWEEN NEAR-INFRARED AND RAMAN CALIBRATION METHODS FOR QUANTIATIVE ANALYSIS OF TABLETS CONTAINING MULTIPLE APIS ...... 441 Md Anik Alam, Md Nayeem Hossain, Douglas Steinbach, James Drennen, Carl Anderson

TOWARDS A UNIVERSAL MODEL FOR BIOPROCESS MONITORING ...... 442 Joana Murtinheira Faustino, Adrian Stacey, Linda Harvey, Brian McNeil

IMPACT OF CHEMICAL AND THERMAL STRESSES ON MONOCLONAL ANTIBODY SECONDARY STRUCTURE BY DEEP UV RESONANCE RAMAN SPECTROSCOPY...... 443 Sergey Arzhantsev, Chen Qiu

MAKING THE LEAP: PATHWAYS FROM GRADUATE SCHOOL TO A PERMANENT POSITION

MAKING THE LEAP: PATHWAYS FROM GRADUATE SCHOOL TO A PERMANENT POSITION...... 443 Anthony Stender, Carrie Lendon, Lisa Brown, Deanna O’Donnell, Jared Anderson, Matt Meyer, Sam Alvarado

NANOSCOPIC POROUS SENSORS

CLUSTER-ENHANCED SINGLE MOLECULE NANOPORE SPECTROMETRY (SMNS): TOWARDS OPTIMAL DETECTION OF PEPTIDES ...... 444 Joseph Reiner, Nuwan Kothalawala, Amy Chavis

POLYMERS AND PEPTIDES CHARACTERIZATION IN CONFINED SPACE ...... 444 Abdelghani Oukhaled

A NEW METHODOLOGY FOR MONITORING PHASE BEHAVIOUR INSIDE NANO-CHANNELS...... 445 Mike George

THIN-FILM NANOFLUIDIC DEVICES FOR SINGLE-MOLECULE SCIENCE...... 446 Jason Dwyer

DEMOCRATIZING NANOPORE-BASED SINGLE-MOLECULE RESEARCH...... 446 Vincent Tabard-Cossa

ATOMIC SPECTROMETRY WITH GLOW DISCHARGES AT ATMOSPHERIC PRESSURE

INVESTIGATIONS OF SAMPLE INTRODUCTION FOR A GLOW DISCHARGE AT ATMOSPHERIC PRESSUREF...... 447 José Broekaert

FROM SOFT IONIZATION TO ELEMENT EXCITATION WITH A DIELECTRIC BARRIER DISCHARGE ...... 448 Joachim Franzke, Sebastian Bandt, Alexander Schütz, David Klute, Antje Michels, Vlasta Horvatic, Cedo Vadla

MICROWAVE-SUSTAINED, INDUCTIVELY COUPLED, ATMOSPHERIC-PRESSURE PLASMA (MICAP): AN ATTRACTIVE ALTERNATIVE TO THE INDUCTIVELY COUPLED PLASMA (ICP) ...... 448 Cera Cissna, Andrew Schwartz, Gary Hieftje

COMPREHENSIVE ELEMENTAL/ISOTOPIC ANALYSIS WITH LS-APGD-MS/OES ...... 449 R. Kenneth Marcus, Edward Hoegg, Htoo Paing

HOW CAN BATTERY-OPERATED MICROPLASMAS ON-CHIPS BE USED FOR ELEMENTAL ANALYSIS OF SOLID MICROSAMPLES?...... 450 Vassili Karanassios

CLINICAL BIOMEDICAL IMAGING

LABEL-FREE BIOLOGICAL IMAGING BELOW THE DIFFRACTION LIMIT USING STIMULATED RAMAN SPECTROSCOPY ...... 450 Christian Graefe, W. Ruchira Silva, Renee Frontiera

HISTOPATHOLOGICAL ANALYSIS OF MELANOCYTIC LESIONS USING PUMP-PROBE MICROSCOPY CAN IMPROVE MELANOMA DIAGNOSIS AND STAGING ...... 451 Francisco Robles

QUANTITATIVE, COMPARABLE BROADBAND COHERENT ANTI-STOKES RAMAN SCATTERING MICROSPECTROSCOPY FOR HIGH-SPEED CELL AND TISSUE IMAGING ...... 452 Charles Camp Jr, Young Jong Lee, Marcus Cicerone

QUANTUM CASCADE LASER INFRARED SPECTROSCOPIC IMAGING: PREDICTING TRANSPLANT OUTCOME ...... 453 Michael Walsh, Vishal Varma, Hari Sreedhar, Imran Uraizee, Aliya Husain, Suman Setty

IN VIVO IMAGING OF ENDOCRINE TISSUE FOR INTRA-OPERATIVE GUIDANCE...... 453 Anita Mahadevan-Jansen, Melanie McWade, Giju Thomas, Melinda Sanders, Carmen Solarzano

RETHINKING CALIBRATION

DEEP SEMI-SUPERVISED GENERATIVE MODELS FOR SPECTROSCOPIC DATA ...... 454 Ian Gemp, Darby Dyar, Mario Parente, Arun Saranath

JOINT MODELING OF CALIBRATION AND INFERENCE IN THE STATISTICAL ANALYSIS OF SPECTROSCOPY DATA ...... 455 Timothy Randolph, Jaroslaw Harezlak

BIG DATA FOR EXTRATERRESTRIAL SPECTROSCOPY ...... 455 Thomas Boucher, Darby Dyar

RETHINKING LOCAL CALIBRATION USING LOCAL ADAPTIVE FUSION REGRESSION ...... 456 Rachel Emerson, John Kalivas

INTEGRATION OF CHEMOMETRIC METHODS WITH TOTAL SYNCHRONOUS FLUORESCENCE SPECTROSCOPY...... 457 Keshav Kumar

FORENSIC ANALYSIS: FROM THE LAB TO THE CRIME SCENE

FORENSIC SCIENCE R&D FUNDING PROGRAM AT THE NATIONAL INSTITUTE OF JUSTICE: OPPORTUNITIES IN ANALYTICAL CHEMISTRY, APPLIED SPECTROSCOPY AND BIOANALYSIS ...... 458 Minh Nguyen, Gregory Dutton

FROM THE LAB TO THE FIELD: TAKING MASS SPECTROMETRY OUT OF ITS ELEMENT AND INTO THE HARSH ENVIRONMENT ...... 459 Guido Verbeck, Kenneth Wright

PIONEERING USES OF HEADSPACE ANALYSIS FOR THE RAPID IDENTIFICATION OF OBJECTS OF FORENSIC INTEREST IN THE FIELD...... 459 Howard Holness, Lauren Colon-Crespo, Adhly Huertas, Vanquilla Shellman, Rodolfo Mesa, Abuzar Kabir, Kenneth G. Furton

A RAMAN ‘SPECTROSCOPIC CLOCK’ FOR BLOODSTAIN AGE DETERMINATION ...... 460 Kyle C. Doty, Gregory McLaughlin, Igor K. Lednev

IDENTIFICATION OF SURFACE DEPOSITED BACTERIA USING VIBRATIONAL SPECTROSCOPY...... 460 Claire Pickering, Elaine Perkins, William Sellors, Roy Goodacre, Matthew Baker

DECODING CIRCULATING BIOMARKERS WITH SPECTROSCOPY: NEXT GENERATION ASSAYS

ILLUMINATING MEMBRANE RECEPTOR RECOGNITION USING PLASMONIC ENHANCEMENTS ...... 461 Zachary Schultz

IMPLANTABLE MATERIALS THAT ENABLE NONINVASIVE METABOLIC MONITORING ...... 462 Mike McShane

DEVELOPMENT OF A MICROFLUIDIC DEVICE FOR DRUG DETECTION ...... 462 Neal Kline, Ashish Tripathi, Rustin Mirsafavi, Chrysafis Andreou, Martin Moskovits, Carl D. Meinhart, Jason Guicheteau, Steven D. Christesen, Augustus W. Fountain III

TOWARDS A RAPID AND SELECTIVE SOLUTION ASSAY FOR BIOPHARMACEUTICAL GLYCOSYLATION ANALYSIS USING LECTIN-COATED NANOPARTICLES AND SERS ...... 463 Craig Ward, Daniel Bracewell, Karen Faulds, Duncan Graham

DEVELOPMENT OF A 3D CELL CULTURE MODEL FOR DRUG DISCOVERY STUDIES USING SURFACE ENHANCE RAMAN SPECTROSCOPY...... 464 Mustafa Culha, Mine Altunbek

RECENT ADVANCES IN SPRAY IONIZATION MASS SPECTROMETRY

ELECTROSPRAY CHARACTERIZATION BY PULSED FIELD ION MOBILITY MASS SPECTROMETRY...... 465 Kaveh Jorabchi, William McMahon, Carina Minardi, Arjuna Subramanian

QUANTITATIVE ANALYSIS OF LIVE SINGLE CELLS USING SINGLE-PROBE MASS SPECTROMETRY TECHNIQUES ...... 465 Zhibo Yang, Ning Pan, Haiqing Yu, Wei Rao

DESORPTION ELECTRO-FLOW FOCUSING IONIZATION AND IN-SOURCE COLLISION INDUCED DISSOCIATION FOR TRACE DETECTION AND CHEMICAL IMAGING OF MILITARY-GRADE AND HOMEMADE EXPLOSIVES...... 466 Thomas Forbes, Edward Sisco, Greg Gillen

ENHANCEMENT FROM VACUUM-ASSISTED PLASMA IONIZATION ON SURFACE ACOUSTIC WAVE NEBULIZATION...... 467 Matthew C. Bernier, Stephen C. Zambrzycki, Joel D. Keelor, Facundo M. Fernandez

DELAYED DESORPTION TO IMPROVE PROTEIN ANALYSIS BY DESORPION ELECTROSPRAY IONIZATION MASS SPECTROMETRY...... 468 Andre Venter, Wisam Alisai, Elahe Honarvar

INFRARED AND RAMAN SPECTROSCOPY GROUP

NANOPARTICLE AGGREGATES PROTECTED IN SWELLABLE POLYMERS AS “SMART” MATERIALS FOR SERS...... 468 Steven Bell, Wendy Lee, Yen Cheng Ho, Ryan Donnelly, Colin McCoy, Louise Jones, Victoria Silverson

BRILLIANT BRILLOUIN AND WAVES. NEW APPROACHES IN BIOMEDICINE ...... 469 Francesca Palombo, Ryan S. Edginton, C. Peter Winlove, Nick Stone, Daniele Fioretto

IN-FIELD DETECTION AND IDENTIFICATION OF THREAT MATERIALS ...... 470 Neil Shand, Clare Nixon, Terry Clark

RAMAN SPECTROSCOPY FOR CYTOPATHOLOGY: LABEL FREE IDENTIFICATION OF CERVICAL PRE-CANCER...... 470 Fiona Lyng

TOWARDS A STANDARDIZED CHARACTERIZATION OF SOLUTION PHASE PROTEIN STRUCTURE USING RAMAN OPTICAL ACTIVITY...... 471 Carl Mensch, Christian Johannessen

NANO-RAMAN

SINGLE MOLECULE SENSITIVITY IN AMBIENT AFM-BASED GAP-MODE TERS...... 472 Marc Chaigneau, Dmitry Evplov, Vasily Gavrilyuk, Andrey Krayev, Ophélie Lancry, Vladimir Zhizhimontov, Sergey Saunin

NEGATIVE IMAGE CONTRAST IN TIP-ENHANCED RAMAN SPECTROSCOPY ...... 472 Andreas Ruediger, Julien Plathier, Chahinez Dab, Jiawei Zhang, Gitanjali Kolhatkar

TWO MECHANISMS OF TIP ENHANCEMENT OF RAMAN SCATTERING BY PROTEIN AGGREGATES ...... 473 Igor Lednev, Valentin Sereda

TERS OF AMYLOID BETA AT NEURONAL SPINES ...... 473 François Lagugné-Labarthet, Mohammadali Tabatabaei

TERS INVESTIGATION OF EXPLOSIVE MIXTURES ...... 474 Volker Deckert, Tanja Deckert-Gaudig, Vincent Pichot, Denis Spitzer

CHEMISTRY IN ART AND ARCHAEOLOGY

MODERN IMAGING TECHNOLOGIES IN HISTORICAL STUDIES ...... 474 Roger Easton, Gregory Heyworth, Keith Knox, Kenneth Boydston, Brent Seales

CHEMICAL MAPPING OF PIGMENTS BY VISIBLE AND NEAR-INFRARED MULTISPECTRAL IMAGING...... 475 Jana Striova

CHARACTERIZATION OF LATE 17TH CENTURY ARTISTS' PIGMENT FROM THE CHILDHOOD HOME OF HENRI TOULOUSE-LAUTREC...... 475 Aaron Shugar

MOBILE RAMAN SPECTROSCOPY IN ARCHAEOMETRY ...... 476 Peter Vandenabeele

IDENTIFICATION OF PIGMENTS IN ART PAINTINGS USING MID IR TO THZ SPECTROSCOPY ...... 476 Sergey Shilov

RECENT DEVELOPMENTS ON MASS CYTOMETRIC ANALYSIS

UNDERSTANDING BIOLOGICAL HETEROGENEITY THROUGH MASS CYTOMETRY ...... 477 Jennifer Frahm, Olga Ornatsky, Dmitry Bandura, Vladimir Baranov, Scott Tanner, Gary Impey, Ashton Breitkreutz

ORGANOTELLURIUM PROBES FOR MASS CYTOMETRY – CHEMICAL BIOLOGY AT THE BOTTOM OF THE PERIODIC TABLE ...... 477 Mark Nitz, Landon Edgar, Ravi Vellanki, Brad Wouters, David Headly

REPRODUCIBILITY AND ROBUSTNESS IN MASS CYTOMETRY ASSAYS ...... 478 Michael Leipold, Holden Maecker

MASS CYTOMETRY FOR THE QUANTIFICATION OF AUTOPHAGY IN INDIVIDUAL CELLS ...... 479 Heather Grundhofer, Edgar Arriaga, Michelle Kuhns

SINGLE-CELL ANALYSIS REVEALS MOLECULAR MECHANISMS OF LEUKEMIA STEM CELL SELF- RENEWAL IN A MURINE MODEL OF AML...... 479 Zohar Sachs, Rebecca Larue, Klara Noble, Conner Hansen, Ngoc Ha, David Largaespada

BIOANALYTICAL APPLICATIONS OF PLASMONICS

MORPHOLOGY-BASED PLASMONIC SENSORS...... 480 Jennifer Chen

SIGNAL ENHANCEMENT AT LIPID BILAYER INTERFACE FOR SPR IMAGING ...... 481 Quan Cheng, Samuel Hinman

CHALLENGES AND SUCCESSES OF PLASMONIC SENSING IN CLINICAL SAMPLES...... 481 Jean-Francois Masson, Alexandra Aubé, Julien Breault-Turcot, David Charbonneau, Joelle Pelletier

NOVEL BIMODAL SPRI/SERS BIOCHIP READER INSTRUMENT AND OPTIMIZATION OF ASSOCIATED PLASMONIC SUBSTRATE STRUCTURES...... 482 Michael Canva

INTEGRATION OF QUANTUM DOTS WITH SPRI FOR ENHANCED SENSITIVITY...... 482 Marinella Sandros

LESTER W. STROCK AWARD PLENARY

SPECTROSCOPY AS AN IMPORTANT KEY FOR UNDERSTANDING MARTIAN PALEOCLIMATES ...... 483 Raymond Arvidson

AES MID CAREER AWARD PLENARY

ELECTROPHORETIC CYTOMETRY: TARGETED PROTEOMICS IN SINGLE CELLS...... 483 Amy Herr

CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY FOR ULTRASENSITIVE BIOANALYSIS

CAPILLARY ZONE ELECTROPHORESIS-MASS SPECTROMETRY FOR ULTRASENSITIVE PROTEOMIC ANALYSIS...... 484 Norman Dovichi, Liangliang Sun, Emily Amenson

CAPILLARY ELCAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY FOR THE CHARACTERIZATION OF INTACT PROTEOFORMS...... 485 Govert Somsen, Elena Dominguez Vega, Jordy Van Angeren, Klara Petru, Sara Tengattini, Rob Haselberg

LIMIT OF DETECTION FOR CAPILLARY ELECTROPHORESIS MASS SPECTROMETRY ...... 485 David Chen

CAPABILITIES AND CHALLENGES USING CAPILLARY ELECTROPHORESIS-ICP-MS TO CHARACTERIZE ENGINEERED NANOPARTICLES ...... 485 Shi Jiao, John Olesik

DIELECTROPHORETIC SORTING OF PLASMID AND GENOMIC DNA ...... 486 Paul Jones, Gabe Salmon, Alexandra Ros

DEVELOPMENT AND APPLICATIONS OF ATMOSPHERIC PRESSURE GLOW DISCHARGES

SCGD – A TECHNIQUE FOR ONLINE ANALYSIS OF LIQUIDS...... 487 David Malmström, Peter Lundin, Arne Bengtson

THE SOLUTION CATHODE GLOW DISCHARGE: A SOURCE FOR ANTITHETICAL APPLICATIONS?...... 488 Steven Ray, Jaime Ibanez-Orejas

METHOD FOR FLAGGING MATRIX EFFECTS IN SOLUTION-CATHODE GLOW DISCHARGE EMISSION SPECTROMETRY ...... 488 Gina Roesch, Andrew Schwartz, Gary Hieftje

OPTIMIZATION OF A DIELECTRIC BARRIER DISCHARGE FOR SOFT IONIZATION OR EXCITATION OF DISSOCIATED MOLECULES ...... 489 Felix David Klute, Antje Michels, Sebastian Brandt, Alexander Schütz, Joachim Franzke

LESTER STROCK AWARD SYMPOSIUM HONORING RAYMOND ARVIDSON

MERCURY: REFLECTANCE SPECTROSCOPY OF A REDUCED, VOLATILE-RICH PLANET...... 490 Scott Murchie

EUROPA: EXPLORING AN OCEAN WORLD USING REFLECTANCE SPECTROSCOPY ...... 490 Diana Blaney

MAPPING MINERALOGY AT GALE CRATER WITH REFLECTANCE SPECTROSCOPY ...... 491 Abigail Fraeman

MARTIAN SURFACE MINERALOGY FROM ROVERS WITH SPIRIT, OPPORTUNITY, AND CURIOSITY ...... 491 Richard Morris

MARS: EARLY AQUEOUS ALTERATION FROM ORBITAL INFRARED AND IN SITU SPECTROSCOPIES ...... 492 Bethany Ehlmann

NOVEL BIOMEDICAL TECHNOLOGIES

RAMAN SPECTROSCOPY FOR BONE QUALITY ASSESSMENT: FROM BENCH TO BEDSIDE...... 492 Xiaohong Bi, Hao Ding

SENSING THE BODY THROUGH GARMENT-INTEGRATED TECHNOLOGIES...... 493 Lucy Dunne

MULTIPLEX MEASUREMENTS OF GLUCOSE, LACTATE AND ANTIBODY THROUGH SINGLE-USE BIOCONTAINER FILMS USING RAMAN SPECTROSCOPY ...... 493 Mekhala Spencer, Yun Xu, Katherine. A. Hollywood, Lorna Ashton, John Welsh, Peter Levison, Alan Dickson, Royston Goodacre

MOLECULAR IMAGING OF CHEMICALLY COMMUNICATING BACTERIAL COMMUNITIES OF THE OPPORTUNISTIC HUMAN PATHOGEN PSEUDOMONAS AERUGINOSA ...... 494 Nameera Baig, Sage Dunham, Sneha Polisetti, Nydia Morales-Soto, Joshua Shrout, Jonathan Sweedler, Paul Bohn

THE ROLE OF LIPOPOLYSACCHARIDES IN THE TOXICITY OF NANOPARTICLES TO GRAM- NEGATIVE BACTERIA...... 495 Joseph Buchman, Emily Caudill, Ariane Vartanian, Lisa Jacob, Xi Zhang, Catherine Murphy, Joel Pedersen, Christy Haynes

METABOLITE PATTERN RECOGITION: THE KEY TO AUTHENTICATION

VALIDATING MULTIVARIATE METHODS FOR PATTERN RECOGNITION...... 495 Richard Brereton

FLOW-INJECTION MASS SPECTROMETRIC FINGERPRINTING - A POWERFUL TOOL FOR AUTHENTICATION PLANT MATERIALS...... 496 Pei Chen, Jianghao Sun, James M. Harnly

INSTANTANEOUS DETERMINATION OF FOOD AUTHENTICITY BY RAPID EVAPORATIVE IONISATION MASS SPECTROMETRY ...... 496 Sara Stead, Emrys Jones, Mike Wilson, Julia Balog, Zoltan Takats, Lorraine Kay

A GENERIC TOOL FOR FLOW INJECTION MASS SPECTROMETRIC FINGERPRINTING...... 497 Mengliang Zhang, Jianghao Sun, Pei Chen

TWO-DIMENSIONAL CORRELATION ANALYSIS - I

EVOLUTION OF TWO-DIMENSIONAL CORRELATION SPECTROSCOPY TECHNIQUES ...... 498 Isao Noda

COMPARABILITY IS ASSESSED FOR MONOCLONAL ANTIBODY FRAGMENTS USING 2D IR AND CO- DISTRIBUTION CORRELATION SPECTROSCOPY...... 499 Belinda Pastrana

A METHOD TO ESTIMATE THE STRENGTH OF INTERMOLECULAR INTERACTION BETWEEN TWO SOLUTES DISSOLVED IN THE SAME SOLUTIONS BASED ON THE DAOSD APPROACH...... 499 Yizhuang Xu, Ran Guo, Anqi He, Jing Chen, Zhanlan Yang, Isao Noda, Jinguang Wu

2D CHEMILUMINESCENCE CORRELATION SPECTROSCOPY FOR POLYMERS...... 500 Hideyuki Shinzawa, Junji Mizukado

ANALYSIS OF THIN FILMS ON SILICON BY P-POLARIZED MULTIPLE ANGLE INCIDENCE RESOLUTION SPECTROMETRY (PMAIRS)...... 500 David Drapcho, Richard Murdey, Nobutaka Shioya, Takeshi Hasegawa

MASS SPECTROMETRY-BASED METABOLOMICS

A GLOBAL VIEW OF STREPTOMYCES COELICOLOR: TRANSCRIPTOMIC, PROTEOMIC, AND METABOLOMIC ANALYSIS OF THE LIFE CYCLE OF A MODEL ANTIBIOTIC-PRODUCING ORGANISM...... 501 Andrew Johnson, Erin Carlson

MAPPING SPECIALIZED BACTERIAL METABOLITE PATHWAYS VIA PATHWAY-TARGETED MOLECULAR NETWORKING...... 502 Jason Crawford, Hyun Bong Park, Corey Perez

METABOLOMICS AND MARINE BACTERIA: TOOLS TO STIMULATE ANTIBIOTIC DISCOVERY...... 502 Tim Bugni, Fan Zhang, Navid Adnani, Doug Braun, Chris Thomas, Yan Zhang

EXPLORING THE MASTER REGULATORS OF MICROBIAL BEHAVIOR...... 502 Erin Carlson

METABOLOMIC TRACKING OF CELL DIFFERENTIATION IN THE CLEAVAGE-STAGE XENOPUS EMBRYO ...... 503 Peter Nemes, Erika P. Portero, Rosemary M. Onjiko, Sally A. Moody

TOPICS IN NANOTECHNOLOGY

RAMAN SPECTROSCOPY OF OPTICAL PHONONS CONFINED IN TIO2 NANOPOWDERS ...... 504 Sergey Mamedov

SYNTHESIS AND CHARACTERIZATION OF STRAINED GEXSN1-X ALLOY NANOCRYSTALS AND IV/II- VI CORE-SHELL NANOCRYSTALS SHOWING ENHANCED PHOTOLUMINESCENCE ...... 505 Brett W. Boote, Long Men, Ujjal Bhattacharjee, Jacob W. Petrich, Javier Vela, Emily A. Smith

MESOPOROUS SILICA-COATED NANOPARTICLES AS A SERS SENSING PLATFORM ...... 505 Zhe Gao, Nathan Burrows, Nicholas A. Valley, George C. Schatz, Catherine J. Murphy, Christy L. Haynes

HIGHLY FLUORESCENT CARBON NITRIDE NANOPARTICLES FOR OPTOSENSING OF MERCURY IONS AND BISPHENOL A ...... 506 Yong-Ill Lee, Bui The Huy , Nguyen Thi Thu Thuy

MECHANISMS OF REDUCTION OF SILVER METAL ION TO SILVER NAOPARTICLES BY ATMOSPHERIC PRESSURE PLASMA JETS ...... 506 Urvashi Gangal, V. S. Santosh K Kondeti, Peter Bruggeman

PAT: FLOW CHEMISTRY AND CONTINUOUS MANUFACTURING MONITORING

DEVELOPING PROCESS CONTROL FOR FLOW CHEMICAL REACTIONS: APPLICATIONS OF SAMPLING, SENSING AND DATA HANDLING ...... 507 Brian Marquardt, Mark Weller, Natasha Hippler, Dave Veltkamp, Michael Roberto

STREAMLINING PHARMACEUTICAL PROCESSES INTO CONTINUOUS OPERATIONS...... 508 Frank Gupton

IN SITU ANALYTICS: A TECHNOLOGICAL SHIFT IN CONTINUOUS PROCESSING ...... 508 Dominique Hebrault

DEVELOPING CHEMOMETRIC MODELS TO SUPPORT CONTINUOUS DRUG PRODUCT MANUFACTURING ...... N/A John-David McElderry, Chunsheng Cai, Justin Pritchard, Kelly Swinney

MODELING AND MONITORING OF BATCH PROCESSES IN RELATIVE TIME...... 509 Heather Brooke

CHIRALITY IN PHARMA

AUTOMATING WORKFLOW TO DETERMINE ABSOLUTE CONFIGURATION BY INTEGRATING VCD, OR, CD SPECTROSCOPY WITH QM CALCULATIONS...... 509 Oliver McConnell, Jano Jusuf, Viral Vyas, Atsu Apedo, Yan He, Daniel Cheney, Malcolm Davis

CHIRAL SEPARATION MECHANISM ON MACROCYCLIC ANTIBIOTICS STATIONARY PHASES: A SPECTROSCOPIC AND CHROMATOGRAPHIC STUDY...... 510 Nelu Grinberg, Ling Wu, Shengli Ma, Heewon Lee, Sherry Shen, Frank Roschangar, Chris Senanayake, David Bell

APPLICATION OF FOURIER TRANSFORM MOLECULAR ROTATIONAL RESONANCE SPECTROSCOPY FOR CHIRAL PURITY CHARACTERIZATION...... 510 Linda H. Kidder, Justin L. Neill, Matthew T. Muckle, Brent J. Harris, Brooks H. Pate

CHARACTERIZATION OF CIPROFLOXACIN TABLETS USING NEAR-INFRARED SPECTROSCOPY AND CHEMOMETRIC MODELING ...... 511 Nathan Fuenffinger, Connie Gryniewicz-Ruzicka

ANALYTICAL APPLICATIONS OF COPOLYMERIZED SILICA NANOPARTICLES...... 512 Gabor Patonay, Maged Henary, Walid Abdelwahab, Gala Chapman

BIOMEDICAL RAMAN SPECTROSCOPY (CLIRSPEC)

INTEGRATED MULTIMODAL SPECTRAL IMAGING FOR MARGIN ASSESSMENT DURING BREAST CONSERVING SURGERY ...... 513 Ioan Notingher

TRACKING PREGNANCY AND LABOR IN VIVO WITH RAMAN SPECTROSCOPY ...... 513 Anita Mahadevan-Jansen, Christine O’Brien, Katherine Cochran, Kelly Bennett, J Michael Newton

DEVELOPMENT OF SERS ACTIVE PHOTOTHERMAL AND MAGNETOTHERMAL NANOPARTICLES FOR THE DIAGNOSIS AND THERAPEUTIC TREATMENT OF ATHEROSCLEROTIC PLAQUES ...... 514 Samuel Mabbott, Karen Faulds, Duncan Graham

KEEPING YOUR HAIR UP: UNDERSTANDING THE BEHAVIOUR OF A COMPLEX KERATIN BASED BIOMATERIAL USING RAMAN SPECTROSCOPY...... 514 Paul Pudney, David David Tiemessen, Christopher Marsh

SPECIES OF INTEREST RECOVERY IN RAMAN SPECTRA OF HETEROTOPIC OSSIFICATION ...... 515 Katherin Cilwa, Ammar Qureshi

RAMAN CONTRIBUTED SESSION

IN VITRO MONITORING OF ADVERSE OUTCOMES PATHWAYS IN AMINATED NANOPARTICLE EXPOSED CELLS BY USING RAMAN SPECTROSCOPY ...... 516 Esen Efeoglu, Alan Casey, Hugh J. Byrne

MONITORING ISOXAZOLE INDUCED DIFFERENTIATION IN PANCREATIC CELL LINES USING RAMAN SPECTROSCOPY ...... 516 Katherine Hollywood, Saba Khan, Karen Cosgrove, Mark Dunne, Nicholas Lockyer, Alex Henderson, Alan Dickson, Roy Goodacre

CONFOCAL RAMAN MICROSCOPY FOR CHARACTERIZING INTERACTIONS OF CYTOCHROME C WITH CARDIOLIPIN-CONTAINING MEMBRANES OF INDIVIDUAL, OPTICALLY-TRAPPED PHOSPHOLIPID VESICLES ...... 517 Jay Kitt, David Bryce, Joel Harris

THE DEVELOPMENT AND APPLICATIONS OF SURFACE ENHANCED SPATIALLY OFFSET RAMAN SPECTROSCOPY...... 518 Fay Nicolson , Neil Shand , Duncan Graham, Karen Faulds

ENCAPSULATED SERS NANOSENSORS – FIBRE-BASED PH SENSING ...... 519 Holly Fleming, Sarah McAughtrie, Mike Tanner, Debaditya Choudhury, Colin Campbell, Mark Bradley

APPLICATIONS OF PHOTOELECTRON SPECTROSCOPY TECHNIQUES TO ANALYSIS OF NANOMATERIALS AND DEVICES

MEMBRANE BASED APPROACH IN AMBIENT PRESSURE PHOTOELECTRON SPECTROMICROSCOPY ...... 519 Andrei Kolmakov

OPERANDO XPS STUDIES OF ELECTROCATALYSIS...... 520 Hirohito Ogasawara

BRIDGING THE GAP – IN SITU STUDY OF SURFACE CHEMISTRY USING AMBIENT PRESSURE X-RAY PHOTOELECTRON SPECTROSCOPY ...... 520 Iradwikanari Waluyo

CHEMICALLY MODIFIED ANTIBODIES TO FORM STABLE GOLD NANOPARTICLE CONJUGATES FOR USE IN LIGHT SCATTERING IMMUNOASSAYS...... 521 Jeremy Driskell, Seth Filbrun, Francis Lovato, Alexandra Mandl

THURSDAY POSTERS – ELECTROKINETIKS-AES

FREE SOLUTION PROTEIN SEPARATION VIA MICROCHIP ELECTROPHORETIC EXCLUSION ...... 521 Fanyi Zhu, Mark Hayes

THE EVALUATION OF CATIONIC LATEX NANOPARTICLES AS PSEUDOSTATIONARY PHASES FOR ELECTROKINETIC CHROMATOGRAPHY...... 522 Julie McGettrick, Chris Palmer, Adam Sutton, Emily Hilder

EXPLORING THE ROLE AND IMPACT OF FARADAIC REACTIONS ON HEMOLYSIS IN NON-UNIFORM AC ELECTRIC FIELDS...... 523 Sanaz Habibi, Hector Moncada-Hernandez, Adrienne Minerick

QUANTITATIVE COMPARISON OF A LASER AND LIGHT-EMITTING DIODE FOR FLUORESCENCE DETECTION WITH CAPILLARY ELECTROPHORESIS ...... 524 Thu Nguyen, S. Douglass Gilman

FLUORIDE TREATMENT OF SILICA CAPILLARY SURFACES ...... 524 Christopher Harrison, Charles Lumba

SEPARATION OF COMPLEX BIOLOGICAL MIXTURES USING ASYMMETRIC POSTS AND ELECTRIC FIELDS...... 525 Mario Saucedo-Espinosa, Blanca Lapizco-Encinas

A PROPOSED CDEP DEVICE DESIGN FOR IMPROVED DEVICE REUSABILITY AND RANGE OF APPLIED VOLTAGE ...... 525 Cynthia Hanson, Elizabeth Vargis

THURSDAY POSTERS – ATOMIC SPECTROSCOPY

PHARMACEUTICAL ATOMIC SPECTROSCOPY: NOT JUST THE METALS LAB ...... 526 Lydia Breckenridge

COMPREHENSIVE LASER PLASMA CHARACTERIZATION THROUGH THE COMBINATION OF EMISSION AND ABSORPTION SPECTROSCOPY...... 527 Nicole Lahaye, Sivanandan Harilal, Mark Phillips

ANALYSIS OF CEDAR FROM WESTERN NORTH CAROLINA FOR ALUMINUM, CALCIUM, AND MAGNESIUM ...... 527 David Butcher

DETERMINATION OF INORGANIC ARSENIC BY OFF-LINE SOLID PHASE EXTRACTION - HYDRIDE GENERATION - MICROWAVE PLASMA ATOMIC EMISSION SPECTROMETRY (HG-MP-AES) ...... 528 Moisés Guerrero Esperanza, Katarzyna Wrobel, Eunice Yáñez Barrientos, Alma Rosa Corrales Escobosa, Francisco Javier Acevedo Aguilar, Kazimierz Wrobel

BIOAVAILABILITY AND QUANTIFICATION OF HEAVY METALS IN CONSUMABLE FISH OF LAKES AND LOCAL SUPERMARKETS BY INDUCTIVELY COUPLED PLASMA-OPTICAL EMISSION SPECTROMETRY (ICP-OES) ...... 529 M Abdul Mottaleb, Daniel R. Johnson, Musavvir Arafat Mottaleb, Kurt Nagel

PERFORMANCE ANALYSIS OF REGULARIZED MLM HYPERSPECTRAL IMAGING FOR MARS RECONNAISSANCE ORBITER CRISM ALONG-TRACK OVERSAMPLED DATA...... 529 Linyun He, Daniel Politte, Joseph O, Raymond Arvidson

DEVELOPMENT OF AN INNOVATIVE INTERFACE FOR THE ANALYSIS OF GASEOUS COMPOUNDS USING PULSED RADIOFREQUENCY GLOW DISCHARGE TIME OF FLIGHT MASS SPECTROMETRY...... 530 Jorge Pisonero, Jonatan Fandiño, Marcos Bouzas, Alfredo Sanz-Medel, Nerea Bordel

SPECTROSCOPY OF LASER-PRODUCED PLASMAS FOR NUCLEAR FORENSICS AND VERIFICATION ...... 531 Kyle Hartig, Nicole Lahaye, Sivanandan Harilal, Mark Phillips, Igor Jovanovic

HIGH-RESOLUTION CONTINUUM SOURCE GRAPHITE FURNACE ATOMIC ABSORPTION SPECTROMETRY FOR THE MONITORING OF AU NANOPARTICLES...... 531 Esperanza Garcia-Ruiz, Raul Garde, Martin Resano

INVESTIGATION OF AMBIENT GAS HEATING AND HYDRODYNAMICS OF LASER-INDUCED SPARKS...... 532 Patrick J Skrodzki, Alex Miloshevsky, Brian E Brumfield, Mark C Phillips, Sivanandan S Harilal

USE OF CAF MOLECULAR EMISSION BANDS FOR IMPROVING THE F QUANTIFICATION CAPABILITIES IN ATMOSPHERIC AIR LIBS...... 532 Jorge Pisonero, Cesar Alvarez-Llamas, Nerea Bordel

DEVELOPMENT OF A XRF DETECTION UNIT FOR CAPILLARY ELECTROPHORESIS...... 534 Inger Marie Tyssebotn, Ursula Fittschen

THURSDAY POSTERS – BIOMEDICAL AND BIOANALYTICAL SCIENCES

DISCOVERY OF G-QUADRUPLEX APTAMERS USING A GENOME-INSPIRED REVERSE SELECTION APPROACH...... 535 Kathleen Morrissey, Christina Albanese, Linda B. McGown

LONGITUDINAL DETERMINATION OF VITAMIN CONCENTRATIONS IN TEARS AND BLOOD SERUM OF INFANTS AND PARENTS ...... 535 Maryam Khaksari, Lynn Mazzoleni, Adrienne Minerick

A NOVEL GROWTH-BASED BACTERIAL VIABILITY ASSAY FOR HIGH-THROUGHPUT NANOPARTICLE TOXICITY SCREENING ...... 536 Tian Qiu, Thu Nguyen, Hilena Frew, Ariane Vartanian, Lisa Jacob, Catherine Murphy, Z. Vivian Feng, Christy Haynes

ELECTROCHEMICAL SENSORS FOR THE RAPID DETECTION OF PSEUDOMONAS AERUGINOSA IN HUMAN WOUND EXUDATE ...... 537 Edgar Goluch, Hunter Sismaet, Anirban Banerjee, Sean McNish, Yongwook Choi, Manolito Torralba, Sarah Lucas, Agnes Chan, Victoria Shanmugam

DUAL FUNCTIONING REPORTER+PROBE BIOSENSORS TO VISUALIZE ABSENCE OR PRESENCE OF MICRORNA ...... 538 Nicholas E. Larkey, Sean M. Burrows

INFLUENCE OF EXPERIMENTAL CONDITIONS ON EQUILIBRIUM CONSTANT DETERMINATION FOR THE THROMBIN-BINDING DNA APTAMERS: BENCHMARKING THE MODEL SYSTEM...... 538 Rebecca Whelan, Kepler Mears, Daniel Markus

TOXICITY OF CHROMIUM IN ZEBRAFISH EMBRYOS...... 539 Jacqueline Arroyo, Rodney Dale, Mark Malham, Martina Schmeline

IDENTIFICATION OF PROTEINS IN TETRAHYMENA THERMOPHILA USING LC-MS/MS ...... 540 Mary Beth Dahl, Zach Turner, Douglas Beussman

ENHANCING THE SPATIAL RESOLUTION OF FAR-FIELD FTIR SPECTROMICROSCOPY VIA LATERALLY STRUCTURED ILLUMINATION ...... 540 Liang Chen, Giovanni Birada, Antoine Masson, Hans Bechtel, Hoi-Ying Holman

CO-LOCALIZED EXCITATION-EMISSION RESOLUTION (CLEER) OF MULTIPLE FLUOROPHORES ...... 541 C. Kyle Almlie, Sean M. Burrows

A METHOD TO AUTOMATE ABCDE LAW APPLIED IN MELANOCYTIC NEVI...... 542 Jorge Castro-Ramos, Adriana May-Salazar, Diana Antonieta Sen-Salinas, Francisco Gutiérrez-Delgado, Reimer Romero- Hernández

USING COPPER OXIDE AS AN INTERFACE FOR HPLC-FTIR ANALYSIS...... 542 Yizhuang Xu, Yan Li, Ran Guo, Yaping Huang, Jing Chen, Isao Noda, Jinguang Wu

THURSDAY POSTERS - CHROMATOGRAPHY

ADVANTAGES AND CHALLENGES ASSOCIATED WITH AUTOMATED SAMPLE PREPARATION FOR ARSENIC SPECIATION ANALYTICAL METHOD...... 542 Rebecca Hunt, Nolan Hilliard, Cynthia Ward, Kathleen Caldwell, Robert Jones

DETERMINATION OF DIMETHYL TRISULFIDE IN RABBIT BLOOD USING STIR BAR SORPTIVE EXTRACTION GAS CHROMATOGRAPHY-MASS SPECTROMETRY...... 543 Erica Manandhar, Ilona Petrikovics, Gary Rockwood, Brian Logue

ANALYSIS OF CHEMICAL MARKERS IN ADULTERATED FUELS USING A TRANSPORTABLE ULTRAFAST MICRO GAS CHROMATOGRAPH...... 544 Jeremy Reyes, Winniford Bill, Jazdzewski Brian, Smith Warren, Asif Zahid, Crandall John, Roques Ned, Parker Spencer, Perron Joe, Holliday Matt

THURSDAY POSTERS – ENVIRONMENTAL AND OCEANOGRAPHIC SCIENCES

ARDUINO CONTROLLED SYNCHRONOUS LIGHT SCATTERING BY PHYTOPLANKTON FOR USE IN A MULTIVARIATE OPTICAL COMPUTING INSTRUMENT...... 544 Stefan Faulkner, Camron Rekully, Shawna Tazik, Tim Shaw, Tammi Richardson, Michael Myrick

TAXONOMIC CLASSIFICATION OF PHYTOPLANKTON WITH MULTIVARIATE OPTICAL COMPUTING: INSTRUMENT IMPROVEMENTS AND COMMUNITY CHARACTERIZATION STRATEGIES...... 545 Cameron Rekully, Stefan Faulkner, Shawna Tazik, Tammi Richardson, Timothy Shaw, Michael Myrick

VERIFYING SUB-SAMPLING AND PREPARATION OF LABORATORY SAMPLES FOR THE ELEMENTAL ANALYSIS OF GRAINS...... 545 Anja Richter

PH QUANTIFICATION CAPABILITY OF SOLUTION-PHASE TETRAKIS(4- CARBOXYPHENYL)PORPHYRIN ...... 546 Matthew Clark, Anselm Omoike

DEGRADATION OF DIMETHYL TRISULFIDE USING SLOW RELEASING MANGANESE OXIDE COATED POTASSIUM PERMANGANATE PARTICLES...... 546 Dustin Harmon, Anselm Omoike

TRACE AQUEOUS LEAD SENSING USING SILICON-ON-INSULATOR RING RESONATORS ...... 547 Xiaowei Wu, Hao Chen, Sogol Borjian, John Saunders, Cathleen M. Crudden, Hans-Peter Loock, Dan-Xia Xu

STUDY OF BPA REMOVAL FROM WATER IN THE PRESENCE OF NORMAL ORGANIC MATTER USING MAGNETIC NANOPARTICLES COATED WITH MANGANESE OXIDE...... 548 James Blume, Anselm Omoike

NOVEL MATERIALS FROM CLAY AND FUNCTIONALIZED CLAY NANOPARTICLES: APPLICATION IN REMEDIATION OF LEAD, CADMIUM AND PENTACHLOROPHENOL FROM WATER...... 548 Wanyika Harrison, David Mutegi Marikah, Erastus Gatebe

THURSDAY POSTERS - LIBS

QUANTITATIVE ANALYSIS OF LASER INDUCED BREAKDOWN SPECTROSCOPY OF ROCK POWDERS DOPED WITH CR, MN, NI, ZN AND CO ...... 549 Kate Lepore, Caleb Fassett, Elly Breves, Stephen Giguere, Thomas Boucher, J. Michael Rhodes, Michael Vollinger, Chloe Anderson, Richard Murray, M. Darby Dyar

BASELINE REMOVAL VERSUS FEATURE SELECTION IN LIBS ...... 550 Darby Dyar, Stephen Giguere, Cj Carey, Thomas Boucher, Ian Gemp

SELF-ABSORPTION STUDY OF COPPER RESONANT LINES IN LASER-INDUCED PLASMAS USING A PHOTOMULTIPLIER TUBE...... 551 Yangting Fu, Richard Warren, Tobias Guenther, Willis Jones, Benjamin Smith, Nicolo Omenetto

DETECTION OF CHLORINE IN CONCRETE USING LASER ABLATION AND CACL EMISSION IN AMBIENT AIR AND HE ENVIRONMENTS...... 551 Will Jones, Tobias Guenther, Yangting Fu, Benjamin Smith, Nicolo Omenetto

PSEUDOCONTINUUM SOURCE ATOMIC ABSORPTION SPECTROSCOPY IN TRANSIENT PLASMAS ...... 552 Jonathan Merten, Alex Goff

LIBS ANALYSIS OF SOILS FROM NEW CALEDONIA TO EVALUATE THE ENVIRONMENTAL IMPACT OF THE EXTRACTION OF NICKEL ORE...... 553 Bruno Bousquet, Julian Guezenoc, Camille Pasquet, Peggy Gunkel-Grillon, Lena Bassel

EFFECTS OF LASER WAVELENGTH ON ALUMINUM PLASMA IN TRANSVERSE MAGNETIC FIELDS...... 553 Payson Dieffenbach, Carolyn Borkowski, Michael Marino, Prasoon Diwakar, Ahmed Hassanein

SPOT SIZE EFFECTS ON PLUME HYDRODYNAMICS OF LASER-PRODUCED PLASMAS IN TRANSVERSE MAGNETIC FIELDS...... 554 Payson Dieffenbach, Carolyn Borkowski, Michael Marino, Prasoon Diwakar, Ahmed Hassanein

ION EMISSION MECHANISMS DURING ULTRASHORT LASER ABLATION OF SOLID TARGETS ...... 555 Ahmed Elsied, Nicholas Termini, Prasoon Diwakar, Ahmed Hassanein

OPTIMIZING SPARK- AND LASER-INDUCED BREAKDOWN SPECTROSCOPY IN AMBIENT GAS CONDITIONS ...... 555 Carolyn Borkowski, Payson Dieffenbach, Arianna Avellan, Prasoon Diwakar, Ahmed Hassanein

PLUME PROPAGATION AND EMISSION DYNAMICS OF TWO COLLIDING PLASMAS...... 556 John Oliver, Tatyana Sizyuk, Prasoon Diwakar, Ahmed Hassanein

DETERMINATION OF THE LOD USING PLSR OF 10B &11B BORIC ACID MIXTURES VIA LASER ABLATION MOLECULAR ISOTOPIC SPECTROSCOPY (LAMIS)...... 556 Candace Harris, Codjo A. Akpovo, Lewis Johnson, Luisa Profeta

THURSDAY POSTERS – MICROSCOPY AND MATERIALS CHARACTERIZATION

MONITORING THE CATALYZED REDUCTION OF NITRITE WITH FLUORESCENCE TECHNIQUES...... 557 Anthony Stender, Emilie Ringe

INTERACTIVE SIMULATION OF BROADBAND IMAGING USING MIE THEORY ON SYMMETRIC SAMPLES ...... 558 Sebastian Berisha, P. Scott Carney, David Mayerich

MULTIRESONANT COHERENT MULTIDIMENSIONAL SPECTROSCOPY IN SEMICONDUCTOR SYSTEMS...... 558 Blaise Thompson, Daniel Kohler, Kyle Czech, John Wright

LINEAR PHOTOTHERMAL IMAGING IN THE MID-INFRARED WITH SUB-DIFFRACTION LIMITED RESOLUTION ...... 559 Atcha Totachawattana, Casey A. Biederman, Karl Muench, Mi K. Hong, Shyamsunder Erramilli, Michelle Y. Sander

THURSDAY POSTERS – PROCESS ANALYTICAL TECHNOLOGY

HIGH THROUGHPUT VIRTUAL SLIT (HTVS) TECHNOLOGY’S PERFORMANCE IMPACT ON RAMAN LIMIT OF DETECTION APPLICATIONS...... 560 Jeremy Linoski, Art Hamfeldt, Bradford Behr, Sharon Deram

USING PLS-DA TO EVALUTATE THE QUALITY OF SPORE INOCULUM TO OPTIMIZE BIOTECHNOLOGICAL PROCESS CONTROL ...... 560 Karin Wieland, Cosima Koch, Julia Kuligowski, Johannes Ofner, Daniela Ehgartner, Christoph Herwig, Bernhard Lendl

ULTRASOUND-ENHANCED IN-LINE RAMAN SENSING OF SOLID SAMPLES IN LIQUID MATRICES ...... 561 Karin Wieland, Stefan Tauber, Stefan Radel, Bernhard Lendl

THURSDAY POSTERS – PHARMACEUTICAL ANALYSIS

SCREENING OF KRATOM PRODUCTS FOR MITRAGYNINE USING ION MOBILITY SPECTROMETRY...... 561 Connie Gryniewicz-Ruzicka, Nathan Fuenffinger, Melissa Ritchie, Ashley Gucinski-Ruth

EFFICIENT NEAR-INFRARED CALIBRATION SET DEVELOPMENT FOR QUANTIATIVE ANALYSIS OF TABLETS CONTAINING MULTIPLE APIS ...... 562 Md Anik Alam, James Drennen, Carl Anderson

MELAMINE DETECTION USING SURFACED ENHANCED RAMAN SPECTROSCOPY (SERS) & 1064 NM HANDHELD RAMAN SPECTROPHOTOMETER ...... 563 Joseph Stoltz, Jonas Sacros

DEVELOP AN EFFECITVE QUALITY CONTROL APPROACH TO DETERMINE POLYMORPH CONTENT IN A PHARMACEUTICAL FORMULATION USING RAMAN SPECTROSCOPY ...... 563 Hanzhou Feng, Yi Li, James Drennen, Carl Anderson

AES MID-CAREER AWARD SYMPOSIUM HONORING AMY HERR

QUANTITATIVE BIOLOGY WITH SINGLE CELLS AND SINGLE ANIMALS ...... 564 Hang Lu

DROPLET MICROFLUIDIC PLATFORM FOR HIGH THROUGHPUT ENZYME SCREENING AND SYNTHETIC BIOLOGY APPLICATIONS...... 564 Anup Singh

MAINSTREAMING MICROFLUIDICS: KEYS TO NAVIGATING COMMERCIALIZATION...... 565 Josh Molho

GENETIC AND FUNCTIONAL ANALYSIS OF CTCS AND TUMOR MICROVESICLES ...... 566 Brian Kirby

MICRO-ASSAYS FOR THE SINGLE CELL...... 566 Nancy Allbritton

CLINICAL VIBRATIONAL SPECTROSCOPY

APPLICATIONS OF RAMAN SPECTROSCOPY IN MONITORING HUMAN MESENCHYMAL STEM CELL DEVELOPMENT INTO BONE...... 567 Ryan Kane, Katherine Lau, Duncan Graham, Karen Faulds, Matthew Dalby, Carol-Anne Smith

MONITORING COMBAT WOUND HEALING BY IR HYPERSPECTRAL IMAGING ...... 567 Ehsan Gazi, Chris Howle, Abigail Spear, Nicole Crane

ENDOSCOPIC RAMAN SPECTROSCOPY FOR CHARACTERIZATION OF INFLAMMATORY BOWEL DISEASE ...... 568 Isaac Pence, Dawn Borromeo Beaulieu, Sarah Horst, David Schwartz, M. Kay Washington, Alan Herline, Anita Mahadevan- Jansen

COMPREHENSIVE BREAST TISSUE CHARACTERIZATION AND MODEL COMPARISONS USING HIGH DEFINITION (HD) INFRARED SPECTROSCOPIC IMAGING ...... 569 Shachi Mittal, Tomasz P. Wrobel, L. Suzanne Leslie, Andre Kadjacsy Balla, Rohit Bhargava

DEVELOPMENT OF A LABEL-FREE RAMAN IMAGING TECHNIQUE FOR DIFFERENTIATION OF INFECTED & NON-INFECTED MALARIA TISSUE...... 569 Laura Frame, James Brewer, Paul Garside, Gianluca Grassia, Karen Faulds, Duncan Graham

THE GOOD, THE BAD AND THE UGLY: FINDING THE HELPFUL VARIABLES AND REMOVING THE HARMFUL VARIABLES IN DATA

AN "ELASTIC" VARIABLE SELECTION APPROACH FOR CALIBRATION ...... 570 Steven Brown, Cannon Giglio

A FEW VARIABLES MORE: FEATURE SELECTION IN SPECTRAL LIBRARY MATCHING ...... 571 Barry Lavine, Collin White, Matthew Allen, Tao Ding

ADAPTIVE REGRESSION VIA SUBSPACE ELIMINATION: NOVEL ALGORITHM FOR PREDICTING IN THE PRESENCE OF UNCALIBRATED CHEMICAL CONSTITUENTS...... 571 Karl Booksh, Joshua Ottaway

MULTIWAY PLS METHOD FOR ESTIMATING THE STRAIN HARDENING MODULUS IN POLYETHYLENE RESINS ...... 571 Paul Deslauriers, Nathan Cole, Collin White, Barry Lavine

CBRNE DETECTION

IMPROVING SENSITIVITY AND SOURCE ATTRIBUTION OF HOMEMADE EXPLOSIVES WITH LOW FREQUENCY/THZ-RAMAN® SPECTROSCOPY...... 572 James Carriere, Anjan Roy, Randy Heyler

CHALLENGING REAL WORLD SAMPLES FOR HANDHELD RAMAN ...... 573 Katherine Bakeev, Kristen Frano, Thomas Padlo, Philip Zhou, Jun Zhao, Dawn Yang

ADVANCING BASIC SCIENCE FOR COUNTERING WEAPONS OF MASS DESTRUCTION...... 573 Cathie Condron

THROUGH-BARRIER EXPLOSIVES AND HAZARDOUS MATERIAL DETECTION USING A HANDHELD SPATIALLY OFFSET RAMAN SPECTROMETER ...... 574 Matthew Bloomfield

DRIVING MEDICINE QUALITY ASSURANCE THROUGH EFFECTIVE AND APPROPRIATE UTILIZATION OF SURVEILLANCE AND SCREENING TECHNOLOGIES ...... 574 Lukas Roth

TWO-DIMENSIONAL CORRELATION ANALYSIS - II

2D CORRELATION STUDY OF CATHODE MATERIALS OF LITHIUM ION BATTERY ...... 575 Young Mee Jung, Yeonju Park, Yeseul Kim, Isao Noda

2D CORRELATION ANALYSIS OF TIME/TEMPERATURE-RESOLVED INFRARED SPECTRA TO PROBE STRUCTURE DEVELOPMENT OF A BIO-BASED, BIODEGRADABLE POLYMER AND ITS THERMALLY REVERSIBLE GEL...... 576 Brian Sobieski, Isao Noda, Liang Gong, John Rabolt, Bruce Chase

RAMAN ANALYSIS OF PHASE TRANSITIONS OF ALKANES AND POLYETHYLENE BY MOVING- WINDOW 2DCOS...... 576 Young Jong Lee, Ying Jin, Anthony P. Kotula, Angela R. Hight Walker, Kalman B. Migler

STRUCTURAL CHANGES OF BREAD UNDER EXTERNAL PERTURBATIONS: A 2DCOS ANALYSIS OF NIR-SPECTROSCOPIC DATA...... 577 Heinz Siesler, Tine Ringsted, Soren Engelsen, Frank Pfeifer

BASELINE REMOVAL USING MANIFOLD OPTIMIZATION ...... 577 Stephen Giguere, Darby Dyar, Sridhar Mahadevan, Cj Carey, Thomas Boucher

LIBS FOR FORENSIC ANALYSIS

LIBS FOR FORENSIC ANTHROPOLOGY...... 578 Matthieu Baudelet

TRACE ANALYSIS OF URANIUM AND ITS ISOTOPIC RATIO DETERMINATION WITH LASER PLASMA SPECTROCHEMISTRY ...... 578 George Chan, Xianglei Mao, Inhee Choi, Vassilia Zorba, Richard Russo

LASER-INDUCED BREAKDOWN SPECTROSCOPY FOR THE RAPID DETECTION OF LEAD-FREE GUNSHOT RESIDUES...... 579 Lashaundra Fambro, Deidre Vandenbos, Matthew Rosenberg, Ethan Miller, Christopher Dockery

STUDY OF MATRIX EFFECTS FOR REPRODUCIBLE LIBS ANALYSIS OF POWDERS ...... 579 Sudeep Jung Pandey, Richard Locke, Mauro Martinez, Romain Gaume, Matthieu Baudelet

SIMULTANEOUS LASER ABSORPTION-EMISSION SPECTROSCOPY OF LASER ABLATION PLUMES...... 580 Sivanandan Harilal, Nicole Lahaye, Mark Phillips

RAPID TESTING USING FIELD-DEPLOYABLE SPECTROMETERS

ASYMPTOTICALLY APPROACHING USABILITY FOR STACKED, MUTUALLY ROTATED GRATINGS AND SHALLOW WELL CMOS CAMERA VISIBLE SPECTROMETRY...... 581 Alexander Scheeline

A NOVEL SPECTRAL IDENTIFICATION METHOD BY MEANS OF VARIABLE REDUCTION AND MULTIVARIATE STATISTICS ...... 581 Jun Zhao

PORTABLE RAMAN WITH VISIBLE EXCITATION: BREAKING ANALYSIS SPEED AND ACCURACY LIMITATIONS...... 582 Aleksandr Mikhonin, Rina Dukor, Laurence Nafie

RAPID TESTING USING FIELD-DEPLOYABLE RAMAN SPECTROMETERS...... 582 Latevi Lawson, Chelliah Navin, Jason Rodriguez

QUANTITATIVE ANALYSIS OF INJECTABLE DRUG PRODUCTS USING NON-INVASIVE WIDEBAND RAMAN TECHNOLOGY...... 583 Bei Ma, Roman Galeev, Anatolyi Saveliev, Arislanov Ilshat

PHARMACEUTICAL APPLICATIONS OF TRANSMISSION RAMAN SPECTROSCOPY

FAST NONDESTRUCTIVE DETECTION OF LOW LEVEL CRYSTALLINE FORMS IN AMORPHOUS SPRAY DRIED DISPERSION USING TRANSMISSION RAMAN SPECTROSCOPY AND COMPARISON TO EXISTING TECHNOLOGIES...... 583 Archana Kumar, Joseph Lubach, Julia Griffen, Matthew Bloomfield, Pavel Matousek, Larry Wigman

ANALYSIS OF POLYETHYLENE OXIDE IN SINTERED PHARMACEUTICAL TABLETS BY TRANSMISSION RAMAN...... 584 Heather Boyce, Stephen W. Hoag

QUANTIFYING PHASE CHANGES IN HIGH THROUGHPUT EXCIPIENT COMPATIBILITY STUDIES USING TRANSMISSION RAMAN SPECTROSCOPY ...... 585 Nicole Canfield, Timothy Rhodes, Matthew Lamm

COMPARISON OF TRANSMISSION RAMAN AND NIR SPECTROSCOPIES FOR THE EFFECTS OF TABLET PHYSICAL PROPERTIES ...... 585 Bruce Thompson, Brandye Smith-Goettler, Gregory Troup, Colleen Neu, Manoharan Ramasamy, Cindy Starbuck

RHEO-RAMAN MICROSCOPY: GAINING INSIGHT TO CHEMICAL, CONFORMATIONAL, MECHANICAL, AND MICROSTRUCTURAL PROPERTIES OF SOFT MATERIALS ...... 586 Matthew Meyer, Anthony Kotula, Jan Plog, Kalman Migler, Angela Hight Walker

ANALYTICAL CHEMISTS EASING WORLD POVERTY

FRUGAL SCIENCE: BUILDING LOW-COST SCIENTIFIC TOOLS FOR GLOBAL EXPLORATIONS IN CHEMISTRY, ECOLOGY AND HEALTH-CARE ...... 586 Saad Bhamla, James Cybulski, George Korir, Manu Prakash

MERGING BUSINESS, SCIENCE, AND CULTURE IN EAST AFRICA ...... 587 Merlin Bicking

THE ROLE OF A WOMAN IN SCIENCE IN POVERTY REDUCTION – “AN AFRICAN PERSPECTIVE”...... 588 Simiso Dube

HANDHELD AND PORTABLE SPECTROSCOPY APPLICATIONS

HAND-HELD LIBS FOR PROVENANCE OF AMMUNITION CARTRIDGES...... 588 Amy Bauer, Robert Robinsky, Kellen Sorauf, Greg Petersen, Markus Gaelli

FROM MULTISPECTRAL FIBER SYSTEMS TO SPECTRAL SENSORS...... 589 Viacheslav Artyushenko, Igor Nazarov

LIBS ANALYSIS OF AGRICULTURAL SOILS : ACCURATE CONTROL OF A PORTABLE LIBS INSTRUMENT TO ASSESS THE ANALYTICAL ABILITY OF THE METHOD...... 590 Bruno Bousquet, Julian Guezenoc, Clement Melkebeke, Lena Bassel, Anne Gallet-Budynek

EVOLUTION OF HANDHELD LIBS: RECENT DEVELOPMENTS IN 2ND GENERATION ANALYZERS...... 590 David Day, Brendan Connors

TOPICS IN MICROFLUIDICS

FREQUENCY DEPENDENT DIELECTROPHORETIC SIGNATURES OF ABO-RH RED BLOOD CELLS...... 591 Hector Moncada-Hernandez, Min Wang, Rob Minerick, Adrienne Minerick

3D PRINTED MICRO FREE-FLOW ELECTROPHORESIS DEVICE...... 591 Sarah Anciaux, Michael Bowser

CHALLENGES TO USING DIELECTROPHORETIC DIAGNOSTIC DEVICES IN LOW-RESOURCE SETTINGS ...... 592 Shannon Huey Hilton, Mark A. Hayes

ELECTRICALLY DRIVEN, PH-MEDIATED SOLID-PHASE EXTRACTION AND PRECONCENTRATION ON MONOLITHS IN MICROFLUIDIC DEVICES ...... 593 Adam Woolley, Mukul Sonker, Radim Knob, Vishal Sahore

DIELECTROPHORETIC RESPONSE OF CONDENSED DNA CLUSTERS IN AC FIELDS ...... 593 Paul Jones, Seunghyun Lee, Gabe Salmon, Alexandra Ros

TOPICS IN CHROMATOGRAPHY

EFFECT OF TEMPERATURE ON THE SHELF-LIFE OF AITC IN HORSERADISH USING HEADSPACE- SOLID-PHASE MICROEXTRACTION-GAS CHROMATOGRAPHY-MASS SPECTROMETRY (HS-SPME- GC-MS)...... 594 Sonali Pandey

CHARACTERIZING VOLATILE POLYMER DEGRADATION COMPONENTS USING FRONTIER PYROLYSIS AND THERMOGRAVIMETRIC ANALYSIS...... 595 Renee Cline, Joan Schroeder

GC-FTIR FOR SOURCE EMISSION MEASUREMENTS OF BTEX...... 595 Allan Bohlke, Martin Spartz, Peter Behnke

MASS SPECTROMETRY FOR COMPREHENSIVE ASSESSMENT OF TOXIC AND NUTRITIONAL ELEMENTS IN DIETARY SUPPLEMENT KELP ...... 596 Lee Yu, Rolf Zeisler, Rabia Oflaz, Rick Paul, Karen Murphy, George Caceres, Brittany Kassim, Stephen Long, Clay Davis, Michael Ellisor

SCANNING PROBE METHODS FOR SURFACE SCIENCE PROBLEMS

CHALLENGES AND SOLUTIONS TO ACHIEVING ROBUST, HIGH-RESOLUTION MULTI-PROPERTY IMAGING ...... 597 Eric Altman, Omur Dagdeviren, Mehmet Baykara, Udo Schwarz

ONE DIMENSIONAL METALLIC GRAIN BOUNDARIES IN TWO DIMENSIONAL SEMICONDUCTORS...... 598 Matthias Batzill

IMAGING WATER REACTIONS WITH REDUCED, STOICHIOMETRIC, AND OXIDIZED RUO2(110) SURFACES ...... 598 Zdenek Dohnalek

ANALYSIS OF REDOX-ACTIVE METAL-ORGANIC CHEMISTRY AT SURFACES BY COMBINATIONS OF SCANNING PROBE MICROSCOPIES AND SURFACE-SENSITIVE SPECTROSCOPIES...... 599 Steven Tait

STM REVEALS THE SPONTANEOUS FORMATION OF SELF-ASSEMBLED MONOLAYERS ON TIO2 IN AIR AND SOLUTION...... 600 Melissa Hines, Erik Skibinski, Anqi Song, William Debenedetti, Amnon Ortoll-Bloch

FACSS INNOVATION AWARD

NANOWELL SAMPLE PREPARATION COMBINED WITH ULTRASENSITIVE LC- AND CE-MS TOWARDS SINGLE CELL OMICS...... 601 Ryan Kelly, Ying Zhu, Yongzheng Cong, Richard Smith

AN INEXPENSIVE MEDICAL DEVICE FOR BARRETT’S ESOPHAGUS SCREENING ...... 601 Rohith Reddy, Michalina Gora, Jing Dong, Matthew Beatty, Wolfgang Trasischker, Kanwarpal Singh, Amna Soomro, Catriona Grant, Mireille Rosenberg, Guillermo Tearney

INNOVATIVE ENVIRONMENTAL MONITORING OF INORGANIC COMPOUNDS BY MEANS OF ‘MICROALGAE SENSORS’...... 602 Frank Vogt, Zachary Ogburn

COMBINING FUNCTIONALISED NANOPARTICLES AND SERS FOR THE DETECTION OF MIRNA BIOMARKERS RELATED TO TYPE 2 DIABETES...... 603 Laila Al Maqbali, Karen Faulds, Duncan Graham

SCIENCE BEYOND BORDERS

MEETING HEALTHCARE NEEDS ACROSS THE GLOBE THROUGH NON-INVASIVE MOLECULAR DIAGNOSTICS ...... 604 Barbara S. Smith

SCIENCE WITH PURPOSE ...... 604 Maureen Tholen

OPPORTUNITIES AND CHALLENGES FOR WOMEN SCIENTISTS AS PRACTITIONERS IN IMPROVING THE QUALITY OF LIFE IN AFRICA...... 605 Simiso Dube

THINGS SCIENTISTS CAN LEARN FROM SCIENCE JOURNALISTS: A TALK ABOUT HOW TO TALK ABOUT YOUR WORK...... 605 Maggie Koerth-Baker

Author Index