Dr. Christian E. BUTZKE Professor of Enology Department of Food Science

Total Page:16

File Type:pdf, Size:1020Kb

Dr. Christian E. BUTZKE Professor of Enology Department of Food Science Dr. Christian E. BUTZKE Professor of Enology Department of Food Science Windows of the World, the largest wine-selling restaurant in the world used to occupy the 106th and 107th floors of One World Trade Center. All 73 of the Windows of the World staff on duty that morning died. CEB 1989 Wine & Health Dysentery BERLIN The Roman Empire Wine & Health Wine vs. Food Poisoning ? Escherichia coli O157:H7 (O-one-five-seven-H-seven) Salmonella enteritidis Listeria monocytogenes Campylobacter jejuni Wine & Health Wine vs. Food Poisoning ! The French Paradox • French diet: high in cream, eggs, cheese, and other foods loaded with low-density “bad” cholesterol • French have much lower rate of heart disease (1/3 of US) The French Paradox CBS "60 Minutes" broadcast November, 1991 http://www.cbsnews.com/video/watch/?id=4750380 n Wine & Media The French Paradox Oxidized “bad” LDL cholesterol builds-up on walls of arteries => heart attack, stroke Wine phenolics from grape skins & seeds are anti-oxidants which may block oxidation IF they make it into the blood stream Alcohol uptake can increase “good” HDL cholesterol protecting against plaque build-up Works only on a daily wine ration basis Binge drinking of wine is ineffective The French Paradox Oxidized LDL Cholesterol Plaque Heart Arteries The French Paradox Wine Consumption (gallons/capita) 2014 - France 11.5 - USA 2.6 - Saudi-Arabia “0” http://www.wineinstitute.org/communications/statistics/keyfacts_worldpercapitaconsumption02.htm The French Paradox Life expectancy - France 82 - USA 80 - Saudi-Arabia 75 The French Paradox Life (years) Annual Wine Consumption (liters) Mediterranean Diet Pyramid Wine & Health 1 Glass of Dry Wine (5 oz) Calories: 105 Carbs: 0 Chemically, alcohol is NOT considered a carbohydrate. Wine & Health Caloric values of wine by style (per 5 oz glass) Alc (%) Alc Cal RS (g/L) Carb Cal Total Cal Red (Zin) 14.5 120 0.2 0 121 Rosé (White Zin) 12 100 34 21 120 White ("dry" Char) 12 100 6 4 103 White ("dry" Riesling) 11 91 14 9 100 No Carb (Slender™) 12 100 0 0 100 De-alcoholized Rosé 0.5 4 58 35 39 Ice Wine 10.5 87 180 110 197 Port Wine-Style 19 158 130 79 237 Wine & Health The Upside Protection against: Heart disease, high blood pressure Reduced platelet aggregation Improved vascular dilation/tone Certain cancers, e.g. prostate, colon, lung Diabetes (NIIDM) Glaucoma / cataract / macular degeneration http://www.webmd.com/search Alcohol & Cancer Excessive Drinking Cancers • Mouth • Larynx • Esophagus • Liver • Colon • Breast • Pancreas • Lung Wine & Health “To alcohol! The cause of, and solution to, all of life's problems.” H. Simpson, 1997 Alcohol & Health Did you know that 33% of Purdue students report having missed a class because of drinking? www.purdue.edu/alcohol Alcohol & Health Uti, non abuti The Downside • Alcoholism and abuse • Accidents • Crime • Medical treatments • Lost productivity • Uncollected taxes • Unpaid health/SS contributions • Preventative measures cost 02/08/2009 Sexual Assault and Alcohol http://www.purdue.edu/sexual_assault Sexual Assault and Alcohol Sexual Assault and Alcohol http://www.purdue.edu/sexual_assault Wednesday, 9/19 Loeb Theater Alcohol & Health Statistic I: Alcohol Consumers (12+ years old) 1: 2 Binge Drinkers (past 30 days) 1: 5 Alcoholics 1: 17 http://www.samhsa.gov http://commons.wikimedia.org/wiki/File:Ethanol_CPK_ani.gif http://www.purdue.edu/hr/pdf/drugAlcoholInformation.pdf Alcohol & Health Statistic II: • Alcohol consumption (by volume): 87% as beer, 8% as wine, 5% as spirits • 11% of US population consumes 88% of all wine J.T. Lapsley, UC Davis Drinking & Driving BloodAlcoholConcentration Legal Limit: 0.08% Your Body Weight / 100 = X Glasses of Wine (5 oz) http://en.wikipedia.org/wiki/Blood_alcohol_content Moderate Drinking Example: 100 lb woman : 1 glass (5 oz) 200 lb dude : 2 glasses (10 oz) NB: 750 mL wine bottle = 25 oz Wine & Pregnancy GOVERNMENT WARNING: (1) According to the Surgeon General, women should not drink alcoholic beverages during pregnancy because of the risk of birth defects. “The campaign against drinking during pregnancy started in 1973 when several studies showed that heavy drinking during pregnancy can cause the condition known as the Fetal Alcohol Syndrome. "What the government conveniently chose to ignore is that this syndrome is extremely rare, occurring only 3 times in 100,000 births, and then only when the mother drinks abusively throughout her pregnancy." Whitten & Lipp, UCSF Odds of Dying Heart Disease 1: 3 Breast Cancer 1: 28 AIDS 1: 213 Drunk Driving (IN) 1: 264 Terrorist Attack 1: 12,802 Lightning 1: 56,439 Who regulates Wine? Dept. of HEALTH & Human Services? FOOD and DRUG Administration? NO! Dept. of the TREASURY? Tax & Trade Bureau? YES! Who regulates Wine? Dept. of the TREASURY? Tax & Trade Bureau (TTB)? YES! Wine Excise Tax (<14% EtOH): $0.21/bottle Alcohol Excise Tax Revenues (2003) : $4,398,717,000 Who regulates Wine? Dept. of the TREASURY? YES! 1927 government ruling: “Illegal profits are taxable” ! Al Capone indicted for income tax evasion Who regulates Wine? Dept. of the TREASURY? YES! December 5, 1933: 21st Amendment “Repeal of Prohibition” Wine Warning Label Required on every bottle 1. GOVERNMENT WARNING: (1) According to the Surgeon General, women should not drink alcoholic beverages during pregnancy because of the risk of birth defects. 2. (2) Consumption of alcoholic beverages impairs your ability to drive a car or operate machinery and may cause health problems. 3. CONTAINS SULFITES Alcohol Labeling 27 CFR §4.36 - Alcoholic content. “Alcohol __ % by volume” A tolerance of 1%, in the case of wines containing more than 14% of alc by vol, and of 1.5%, in the case of wines ("table wines") containing 14% or less of alc by vol, will be permitted either above or below the stated percentage. Organic Wine Labeling 1. “100 % Organic Wine” cannot include any non-organic substances. No added sulfites. 2. “Organic Wine” can include up to 5 % non- organic agricultural ingredients that are not commercially available in organic form and other substances, including yeast, allowed by 7 CFR 205.605. No added sulfites. => organic? 3. “Wine made with Organic Ingredients” can include up to 30 % non-organic ingredients. Up to 100 mg/L sulfur dioxide. => organic??? Wine Warning In FRANCE Editorial story on wine = Advertising => http://www.winesandvines.com/template.cfm?section=news&content=52385 “Contains Sulfites” 1. Microbial Stability 2. Inhibition of Browning Enzymes 3. Binding of Acetaldehyde 4. Antioxidant Activity “Contains Sulfites” 5% of asthmatics have severe adverse reaction Affects possibly 1 in 600 people No evidence to cause headaches European don’t contain less than US wines Legal limit is 350 mg/L for wine (US) Wine contains on average 74 mg/L SO2 Wine Headache? Drink 1 glass of water with every glass of wine! + Wine Headache? © Mauricio Alejo.
Recommended publications
  • Can American Medicine Learn from Past Mistakes?
    COMMENTARY To Err is Human: Can American Medicine Learn from Past Mistakes? Jeffrey B Ritterman, MD Perm J 2017;21:16-181 E-pub: 06/14/2017 https://doi.org/10.7812/TPP/16-181 ABSTRACT seasoned researchers in overcoming a “set infants would be put to bed and found The history of medicine includes of well entrenched beliefs that conflicted dead in the morning. In 1830, patholo- many errors. Some persisted for decades with the new ideas.”3 gists noted that SIDS-affected infants had and caused great harm. Several are It took a generation for Marshall and enlarged thymus glands compared with highlighted in this article, including the Warren’s pioneering work to be recognized “normal” autopsy specimens.7 It seemed mythical thymic diseases: thymic asthma and acknowledged. They first published logical to conclude that these “enlarged” and status thymicolymphaticus. Some their findings onH pylori in 1984. More glands were in some way responsible for medical mistakes, such as the diet-heart than a decade later, in 1995, only 5% of the deaths. hypothesis of Ancel Keys, continue to American physicians were prescribing anti- In 1830, Kopp introduced the term cause harm. To avoid future errors and biotics for treatment of peptic ulcer disease.3 thymic asthma, suggesting that the “en- their associated harm, I suggest a cultural In 2005, Marshall and Warren received the larged” thymus occluded the trachea.8 The shift encouraging professional humil- Nobel Prize in Medicine for their discovery, existence of this fictitious disease became ity and greater questioning of medical 26 years after Warren discovered H pylori.2 widely and quickly accepted, and persisted dogma.
    [Show full text]
  • Cardiovascular Risk Is More Related to Drinking Pattern Than to the Type of Alcoholic Drinks
    rEViEW Cardiovascular risk is more related to drinking pattern than to the type of alcoholic drinks A. van de Wiel1*, D.W. de Lange2 1Department of Internal Medicine, Meander Medical Centre, Amersfoort, the Netherlands, 2Department of Clinical Toxicology, University Medical Centre and National Poisons Information Centre of the National Institute for Public Health and the Environment, Utrecht, the Netherlands, *corresponding author: e-mail: [email protected] ABsTract IntroductioN Many observational studies have shown an association Health aspects of alcohol have been debated for centuries. between moderate alcohol consumption and a lower Alcoholic drinks have been used as restoratives, stimulants, risk for cardiovascular morbidity and mortality. some appetizers, and even as analgesics for many of the body’s of these studies, whether or not inspired by the french aches. But alcohol consumption has also proven to be paradox, suggest a more favourable effect of wine than associated with liver disease, cardiomyopathy, trauma and of other alcoholic drinks. Certain polyphenols including injuries, the Wernicke-Korsakov syndrome and some forms the flavonoids, more abundant in red than in white wine, of cancer. are held responsible for this ‘bonus’ effect. However, this In ancient and medieval times, wine and beer were part of conclusion seems premature, since no significant bioactive everyday diet, because many places on earth lacked reliable effect of wine polyphenols has been shown in humans so sources of drinking water. Nowadays, they are mostly far. furthermore, wine drinking proves to be associated regarded as regular staples of modern day living and their with a healthier lifestyle profile than consumption of beer consumption parallels the increase in welfare.
    [Show full text]
  • Drunk People – They Are out to Get to You
    Drunk people – They are out to get to you Abe Markin Dec 2014 TBL Outline • Physiology • They’re out to get you • Management of intoxication in ED – ABCs etc. – Do you have to check BAC? – Alcoholic Ketoacidosis • Wernicke’s • Korsakoff’s • 4 Phases of withdrawal • Holiday Heart Physiology • Absorbed primarily in stomach (70%) and duodenum (25%) • Distributed evenly throughout all organ systems • Traditionally thought to be zero order kinetics • First order kinetics for high levels, especially in heavy drinkers – 10% in gastric mucosa (first pass) – Remaining 90% in liver – Inducible CYP-450 enzymes in microsomal ethanol oxidizing system (MEOS; 8–10%) – Catalase (0–2%) • Respiratory depression, decreased airway responsiveness cause death Rosen’s 7th Edition; Vonghia et al. (Eur J Intern Med, 2008) How Drunks Might Get You • Other causes of AMS – Other toxins (toxic alcohols, benzos) – Head bleed – Infection (meningitis, sepsis), – Metabolic disturbances (AKA, DKA, hypoglycemia, hyponatremia, hepatic encephalopathy, uremia, hypoxia/CO2 narcosis) – Seizures (post-ictal / status) – Withdrawal syndromes • Missed injuries – Orthopedic, – C-spine – Intra-abdominal • Vomiting while supine in 4 points All drunks deserve… • ABC, fluids, nutrition, consider withdrawal • Benzos if needed • Volume depletion – Give IVF (D5 0.9 NS) • Nutrition – D5/food (No glycogen stores) – Thiamine (100mg) – Electrolytes: replace magnesium (1-2g/0-60min), potassium – MVI Slovis. (AAEM, 2007); Li et al. (Am J Emerg Med, 2008) Should we get a BAC? • Rosen: “Discharge (after excluding significant abnormal laboratory values or suspected head injury) can be considered when a patient is clinically sober and able to dress, walk, and function independently.” • Tintinalli: “Patients with no other medical reason for admission may be discharged when their clinical intoxication has resolved to the extent that they do not constitute a danger to themselves or others.
    [Show full text]
  • THE FRENCH PARADOX: LESSONS for Heart: First Published As 10.1136/Heart.90.1.107 on 15 December 2003
    Coronary disease THE FRENCH PARADOX: LESSONS FOR Heart: first published as 10.1136/heart.90.1.107 on 15 December 2003. Downloaded from OTHER COUNTRIES Jean Ferrie`res 107 Heart 2004;90:107–111 ‘‘Life is the art of drawing sufficient conclusions from insufficient premises’’ —Samuel Butler he French paradox is the observation of low coronary heart disease (CHD) death rates despite high intake of dietary cholesterol and saturated fat.12 The French paradox concept was Tformulated by French epidemiologists3 in the 1980s. France is actually a country with low CHD incidence and mortality (table 1). The mean energy supplied by fat was 38% in Belfast and 36% in Toulouse in 1985–86.4 More recently, in 1995–97, the percentage of energy from fat was 39% in Toulouse according to a representative population survey. c THE FRENCH PARADOX AND CAUSES OF DEATH The first source of error could come from an underestimated CHD mortality. According to this hypothesis, French physicians may not declare all the CHD deaths as CHD. If standardised data— for example those provided by the MONICA (monitoring of trends and determinants in cardiovascular disease) project—are used, the results concerning CHD attack and mortality rates show that France is at a low risk for CHD (table 1). Under certification of CHD deaths in France is a possible bias, but after correction, it remains a low bias. Thus, validated data on CHD mortality and incidence show that France is characterised by CHD risk, corroborating the first part of the French paradox definition. http://heart.bmj.com/ THE FRENCH PARADOX AND SATURATED FAT In correlation studies, measures that represent characteristics of an entire population (consumption of animal fat, daily milk, and alcohol) are used to describe disease (CHD mortality).
    [Show full text]
  • Beyond the French Paradox: the Impact of Moderate Beverage Alcohol and Wine Consumption in the Prevention of Cardiovascular Disease Tedd M
    Cardiol Clin 21 (2003) 449–457 Beyond the French paradox: the impact of moderate beverage alcohol and wine consumption in the prevention of cardiovascular disease Tedd M. Goldfinger, DO, FACCa,b,c,* aDesert Cardiology of Tucson Heart Center, 6080 N. La Cholla Boulevard, Tucson, AZ 85741, USA bDivision of Cardiology, University of Arizona School of Medicine, Tucson, AZ 85719, USA cWine & Heart Health Research Initiative Desert Heart Foundation, Tucson, AZ 85741, USA Cardiovascular disease (CVD) is the leading associated with moderate alcohol consumption. cause of death and disability in the United States Plausible biologic mechanisms for vascular pro- and is responsible for 53% of deaths in women and tection from beverage alcohol is discussed in this 46% of deaths in men. [1] CVD is a primary or article. The medical community has been cau- contributing cause in 60% of all deaths, and claims tioned not to expound the health benefits of as many lives as the next leading causes of death alcohol, and particularly wine. In a letter, Ellison including cancers, accidents, infections, and pul- countered that, ‘‘telling people to avoid any alco- monary disease. Coronary heart disease (CHD) hol consumption, because of the potential dan- affects 12 million people in the United States of gers of heavy use may not be in the best health which 1.1 million have a myocardial infarction interest of the public’’ [7]. Most agree that in the annually and about one third die. Worldwide, absence of a well-executed, randomized, double- CVD is the foremost cause of death, accounting blinded, intervention trial, controlled for con- for 57% of deaths among developing nations, and founding variables, the debate as to the health the second most cause of disability [2].
    [Show full text]
  • The Oxygen Paradox, the French Paradox, and Age-Related Diseases
    GeroScience (2017) 39:499–550 https://doi.org/10.1007/s11357-017-0002-y REVIEW ARTICLE The Oxygen Paradox, the French Paradox, and age-related diseases Joanna M. S. Davies & Josiane Cillard & Bertrand Friguet & Enrique Cadenas & Jean Cadet & Rachael Cayce & Andrew Fishmann & David Liao & Anne-Laure Bulteau & Frédéric Derbré & Amélie Rébillard & Steven Burstein & Etienne Hirsch & Robert A. Kloner & Michael Jakowec & Giselle Petzinger & Delphine Sauce & Florian Sennlaub & Isabelle Limon & Fulvio Ursini & Matilde Maiorino & Christina Economides & Christian J. Pike & Pinchas Cohen & Anne Negre Salvayre & Matthew R. Halliday & Adam J. Lundquist & Nicolaus A. Jakowec & Fatima Mechta-Grigoriou & Mathias Mericskay & Jean Mariani & Zhenlin Li & David Huang & Ellsworth Grant & Henry J. Forman & Caleb E. Finch & Patrick Y. Sun & Laura C. D. Pomatto & Onnik Agbulut & David Warburton & Christian Neri & Mustapha Rouis & Pierre Cillard & Jacqueline Capeau & Jean Rosenbaum & Kelvin J. A. Davies Received: 7 November 2017 /Accepted: 9 November 2017 /Published online: 21 December 2017 # The Author(s) 2017. This article is an open access publication Abstract A paradox is a seemingly absurd or impossi- 1997)?: the so-called Oxygen Paradox (Davies and ble concept, proposition, or theory that is often difficult Ursini 1995; Davies Biochem Soc Symp 61:1–31, to understand or explain, sometimes apparently self- 1995). How can French people apparently disregard contradictory, and yet ultimately correct or true. How the rule that high dietary intakes of cholesterol and is it possible, for example, that oxygen Ba toxic envi- saturated fats (e.g., cheese and paté) will result in an ronmental poison^ could be also indispensable for life early death from cardiovascular diseases (Renaud and (Beckman and Ames Physiol Rev 78(2):547–81, 1998; de Lorgeril Lancet 339(8808):1523–6, 1992; Catalgol Stadtman and Berlett Chem Res Toxicol 10(5):485–94, et al.
    [Show full text]
  • Bar Le French Paradox
    Bar Le French Paradox Le French Paradox : constat américain de l’allongement de l’espérance de vie chez les Français qui consomment du vin rouge de façon raisonnable. A votre santé ! The French Paradox: Statistics and reports by American cardiologists showed the positive effects of red wine consumption with regard to fighting cardiovascular disease. Cheers! Prix Nets – Service compris – Net Prices - Service included Nos vins au verre Wines by the glass Champagne (15 cl) Deutz Brut Classique 15 € Deutz Brut Rosé 19 € Krug Grande Cuvée 45 € Vins blancs (15 cl) White wines Les Hauts de Smith, Pessac-Léognan 2017 13 € Château Olivier, Pessac-Léognan 2017 16 € Château Smith Haut Lafitte, Pessac-Léognan 2014 39 € Vins rouges (15 cl) Red wines Les Hauts de Smith, Pessac-Léognan 2016 13 € Château Carbonnieux, Pessac-Léognan 2014 18 € Château Smith Haut Lafitte, Pessac-Léognan 2012 37 € Vin Liquoreux Sweet wines Château Cyprès de Climens, Sauternes 2009 16 € Prix Nets – Service compris – Net Prices - Service included Apéritifs Aperitives (6 cl) Lillet blanc ou rouge / Lillet White or Red 10 € Pineau des Charentes Beaulon rouge / red 5 ans 10 € Pineau des Charentes Beaulon blanc / white 5 ans 10 € Pineau des Charentes Beaulon rouge / red 1981 15 € Pineau des Charentes Beaulon blanc /white 1982 15 € Pineau des Charentes Bourgoin blanc / white 15 € Pineau des Charentes Bourgoin 1979 50 € Apérol, Bitter Q, Campari (6 cl) 10 € Byrrh Grand Quinquina (6 cl) 10 € Kir (15 cl) 10 € Kir Royal (15 cl) 18 € Martini blanc ou rouge / white or red (4 cl) 10 €
    [Show full text]
  • 13 Years' Observations on Male British Doctors
    25 Medical Research Council. Tobacco smoking and cancer of the lung. BMJ 37 Doll R, Peto R, Hall E, Wheatley K, Gray R. Mortality in relation to 1957;i:1523. comsumption of alcohol: 13 years' observations on male British doctors. 26 Doll R, Forman D, La Vecchia C, Woutersen R. Alcoholic beverages and BM 1994;309:91 1-8. cancers of the digestive tract and larynx. In: Verschuren PM, ed. Health 38 Peto R, Lopez A, Boreham J, Thun M, Heath C. Mortality from tobacco in issues related to akoholconsumption. Washington, DC: ILSI Press, 1993. developed countries: indirect estimation from national vital statistics. Lancet 27 Key T. Diet and smoking related disease: lung cancer and coronary heart 1992;339: 1268-78. disease. journal ofTobacco-related Disease (in press). 39 Baron JA, Sandler RS. Cigarette smoking and cancer of the large bowel. In: 28 Stamler J, Wentworth D, Vaccaro 0, Neaton JD. Diabetes, other risk factors, Wald N, Baron J, eds. Smoking and hornone related disorders. Oxford: and 12-year cardiovascular mortality for men screened in the multiple risk Oxford University Press, 1990:167-80. factor intervention trial. Diabetes Care 1993;16:434-44. 40 Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Aschero A, Keamey J, 29 National Research Council. Health risks of radon and other internally deposited et al. A prospective study of cigarette smoking and risk of colorectal alpha-emitters. BEIR IV. Washington, DC: National Academy Press, 1988. adenoma and colorectal cancer in US men. J Nad Cancer Inst 1994;86: 30 Bosch FX, Mufloz N, De Sanjose S, Izarzugaza I, Gili M, Viladiu P, et al.
    [Show full text]
  • Chemical Dependency CD440
    Drugs in American Society CHD 601 “Legal Drugs” Alcohol Unit 2 Last updated – April 12, 2017 Edward Pierce, LCSW Overview • From the last class – Counseling videos – Quiz 1 Process – Other items • Alcohol – Biochemical effects – Psychological effects – Assesment – Alcohol Use & Age, Gender, Ethnicity – Family effects – Social effects Effects of drug use • The effects of drug use are quite variable from one person to another. • Some people have fairly significant effects at low amounts, others seem to have little effect. • We have limited understanding of which people will have significant impacts and why. “Legal” Drugs • Alcohol and tobacco are legal, can be a physically destructive “drug” • 10 million Americans drink heavily Alcohol • Actually Ethanol is what is commonly consumed • 200 Proof is 100% ethanol • Beer is 4% ethanol • Wine 10 to 13% • 1 Mixed drink = glass of wine • Distilled spirits can be 50% ethanol or more Blood Alcohol Levels • .08 Legally Drunk in California and U.S. • .35 Death for half of all individuals – Also called (LD50) LD=lethal dose • .8 Death for all individuals (LD100) • Absorption faster for women • Healthy limits are two standard drinks for men, and one for women, in one hour • You can find the a Blood Alcohol Level chart at http://www.brad21.org/bac_charts.html Alcoholic Depression • Alcohol is a depressant, particularly with heavy or severe use. • One can be diagnosed as “Alcoholic Depression” which is a possible result of alcohol use. • Abstinence may relieve the symptoms and the person may not need anti-depressants
    [Show full text]
  • To Drink Or Not to Drink? That Is the Question
    To Drink or Not to Drink? That Is the Question Samer Kanaan, M.D. Goals Review Briefly my credentials and background Heart Disease – The Problem The French Paradox Review Heart-Health Benefits of Red Wine Biology Recommendations on Red Wine Consumption Heart Disease Estimated 80 million Americans have one or more type of Cardiovascular Disease 1 in 3 American Adults Cardiovascular Disease accounts for 35.3% of all deaths in 2005, or one of every 2.8 deaths in the United States. 2,400 Americans die of CVD each day one death every 37 seconds In every year since 1900 except 1918, CVD accounted for more deaths than any other cause. Cardiovascular Disease claims more lives each year than Cancer, Chronic Lower Respiratory Diseases, Accidents, and Diabetes Mellitus COMBINED! The French Paradox History of Alcohol and Health Hippocrates Illustrated the value of wine as a medicine and vital to a healthy diet. Paracelsus (German physician 16th century) “Whether wine is nourishment, medicine, or poison is a matter of dosage.” Thomas Jefferson “wine of long habit has become indispensable to my health” “I think it a great error to consider a heavy tax on wine as a tax on luxury. On the contrary, it is a tax on the health of our citizens.” Louis Pasteur “wine to be the most healthful and hygienic of beverages.” William Heberden – 1786 described angina pectoris “wines and spirituous liquors afford considerable relief” Renaud and DeLongeril Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992. Mortality rate for coronary heart disease in France was paradoxical and unexpectedly lower than other industrialized countries, such as the United States and the United Kingdom, despite similarly high dietary intake of saturated fat and the prevalence of other risk factors, such as smoking.
    [Show full text]
  • Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's
    International Journal of Molecular Sciences Review Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis Bin Peng 1, Qiang Yang 2, Rachna B Joshi 1,3, Yuancai Liu 2, Mohammed Akbar 4, Byoung-Joon Song 5 , Shuanhu Zhou 6,* and Xin Wang 1,* 1 Departments of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA; [email protected] (B.P.); [email protected] (R.B.J.) 2 Hubei Provincial Key Lab for Quality and Safety of Traditional Chinese Medicine Health Food, Jing Brand Research Institute, Daye 435100, China; [email protected] (Q.Y.); [email protected] (Y.L.) 3 Internal Medicine, Stafford Medical, PA. 1364 NJ-72, Manahawkin, NJ 08050, USA 4 Division of Neuroscience & Behavior, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA; [email protected] 5 Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20892, USA; [email protected] 6 Departments of Orthopedic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA * Correspondence: [email protected] (S.Z.); [email protected] (X.W.); Tel.: 1-617-732-5398 (S.Z.); 1-617-732-4186 (X.W.) Received: 25 February 2020; Accepted: 24 March 2020; Published: 27 March 2020 Abstract: Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), increase as the population ages around the world.
    [Show full text]
  • Moderate Alcohol Intake in Non-Alcoholic Fatty Liver Disease: to Drink Or Not to Drink?
    nutrients Review Moderate Alcohol Intake in Non-Alcoholic Fatty Liver Disease: To Drink or Not to Drink? Maria L. Petroni * , Lucia Brodosi, Francesca Marchignoli, Alessandra Musio and Giulio Marchesini * Department of Medical and Surgical Sciences, “Alma Mater” University, Sant’Orsola-Malpighi Hospital, Via Massarenti 9, 1-40135 Bologna, Italy; [email protected] (L.B.); [email protected] (F.M.); [email protected] (A.M.) * Correspondence: [email protected] (M.L.P.); [email protected] (G.M.) Received: 31 October 2019; Accepted: 10 December 2019; Published: 13 December 2019 Abstract: Nonalcoholic fatty liver disease (NAFLD) is defined by hepatic steatosis in the presence of alcohol intake within safe limits, defined by guidelines of scientific associations (usually 20 g or 2 units/day in women, 30 g or 3 units in men). The diagnosis is usually followed by medical counseling of total abstinence, in order to prevent disease progression. This policy has been challenged by epidemiological studies, suggesting that the risk of liver disease and disease progression is lower in modest drinkers than in total abstainers. We revised the literature on the effects of modest alcohol intake on disease burden. Epidemiological data may suffer from several potential biases (recall bias for retrospective analyses, difficulties in the calculation of g/day), limiting their validity. Prospective data suggest that NAFLD patients with regular alcohol intake, although within the safe thresholds, are at higher risk of liver disease progression, including hepatocellular carcinoma; a detrimental effect of modest alcohol drinking is similarly observed in liver disease of viral etiology. Alcohol intake is also a risk factor for extrahepatic cancers, particularly breast, oral, and pharyngeal cancers, with gender difference and no floor effect, which outweigh the possible beneficial effects on cardiovascular system, also derived from retrospective studies.
    [Show full text]