DOCSLIB.ORG

Bibliography of Hookworm Disease (Ancylostomiasis)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

BIBLIOGRAPHY OF HOOKWORM DISEASE (ANCYLOSTOMIASIS) BIBLIOGRAPHIE DE L'ANKYLOSTOMIASE World Health• Organization Organisation mondiale de la Sante Geneve Il)65 BIBLIOGRAPHY OF HOOKWORM DISEASE BIBLIOGRAPHIE DE L' ANKYLOSTOMIASE BIBLIOGRAPHY OF HOOKWORM DISEASE (ANCYLOSTOMIASIS) 1920-1962 BIBLIOGRAPHIE DE L'ANKYLOSTOMIASE 1920-1962 WORLD HEALTH ORGANIZATION •tt ORGANISATION MONDIALE DE LA SANTE GENEVE 1965 © World Health Organization 1965 Publications of the World Health Organization enjoy copyright protection in accord­ ance with the provisions of Protocol 2 of the Universal Copyright Convention. Never­ theless governmental agencies or learned and professional societies may reproduce data or excerpts or illustrations from them without requesting an authorization from the World Health Organization. For rights of reproduction or translation of WHO publications in toto, application should be made to the Division of Editorial and Reference Services, World Health Organization, Geneva, Switzerland. The World Health Organization welcomes such applications. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Director-General of the World Health Organization concerning the legal status of any country or territory or of its authorities, or concerning the delimitation of its frontiers. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. PRINTED IN SWITZERLAND © Organisation mondiale de la Sante 1965 Les publications de !'Organisation mondiale de la Sante beneficient de la protection prevue par les dispositions du Protocole N° 2 de la Convention universelle pour la Protection du Droit d'Auteur. Les institutions gouvernementales et les societes savantes ou professionnelles peuvent, toutefois, reproduire des donnees, des extraits ou des illustrations provenant de ces publications, sans en demander l'autorisation a !'Organi­ sation mondiale de la Sante. Pour toute reproduction ou traduction integrale, une autorisation doit etre demandee a la Division des Services d'Edition et de Documentation, Organisation mondiale de la Sante, Geneve, Suisse. L'Organisation mondiale de la Sante sera toujours tres heureuse de recevoir des demandes a cet effet Les designations utilisees dans cette publication et la presentation des donnees qui y figurent n'impliquent de la part du Directeur general de !'Organisation mondiale de la Sante aucune prise de position quant au statut juridique de tel ou tel pays ou terri­ toire, ou de ses autorites, ni quant au trace de ses frontieres. Sauf erreur ou omission, une majuscule initiale indique qu'il s'agit d'un nom depose. IMPRIME EN SUISSE CONTENTS Introduction . 7 Principal sources consulted . 10 List of references . 11 Index ......... 223 TABLE DES MATIERES Introduction . 9 Sources principales consul tees. 10 Liste de references. 11 Index .......... 239 INTRODUCTION The compilation of this bibliography of the world literature on hook­ worm disease (ancylostomiasis) was made possible through the financial assistance of the Rockefeller Foundation. It covers material published between 1920 and 1962 and thus brings up to date the bibliography published over forty years ago by the Rockefeller Foundation: ROCKEFELLER FOUNDATION Bibliography on hookworm disease. New York, 1922. 417 p. (Rockefeller Foundation. International Health Board Publication No. 11) In order to make the present bibliography as comprehensive as possible and to ensure a wide geographical coverage, a systematic search was made of important medical works of reference. A list of the principal sources consulted in addition to the indexes and catalogues of the World Health Organization Library will be found on page 10. Whenever possible, references cited have been verified from the original material, and for the textbooks only the latest known edition has been cited. Serial publications, such as reports issued at regular intervals by govern­ ments or private bodies, have not, in general, been included. As a general rule, titles of articles and books have been given in the original language, Cyrillic characters being transliterated in accordance with the system recommended by the International Organization for Standardization. In the case of material published in Chinese or Japanese, the title of the article in square brackets is as given in the source from which the reference was obtained. The references are arranged alphabetically by author, each item being numbered. A combined subject and geographical index in English and in French, referring to the item numbers, will be found at the end of the bibliography. The headings for this subject index were prepared by an international group of experts on helminthiases. So far as possible, pharmaceutical preparations have been entered in the index under the name appearing in the Cumulative list of proposed international non-proprietary names for pharmaceutical preparations, Geneva, World Health Organiza­ tion, 1962. -7- INTRODUCTION La presente bibliographie de l'ankylostomiase a ete etablie grace a l'aide financiere de la Fondation Rockefeller. Elle mentionne les ouvrages et les articles parus entre 1920 et 1962, et constitue ainsi une mise a jour de la bibliographie publiee il y a plus de quarante ans par la Fondation Rockefeller: ROCKEFELLER FOUNDATION Bibliography on hookworm disease. New York, 1922. 417 p. (Rockefeller Foundation. International Health Board Publication No. 11) Afin de rendre ce travail aussi complet que possible du point de vue technique et geographique, on a methodiquement consulte les ouvrages importants de references medicales. On trouvera a la page 10 la liste des principales sources dont on s'est servi en plus des index et catalogues de la Bibliotheque de !'Organisation mondiale de la Sante. Les references ont ete verifiees, dans la mesure du possible, sur le travail original meme; dans le cas des manueis; seule la derniere edition connue est mentionnee. Les publications periodiques, telles que les rapports publies a intervalles reguliers par des organismes publics ou prives, ont ete exclues. En regie generale, les titres des articles et des ouvrages sont donnes dans la langue originale; les caracteres cyrilliques ont ete translitteres conforme­ ment au systeme recommande par !'Organisation internationale de Norma­ lisation. Pour les publications parues en chinois ou en japonais, on a repro­ duit entre crochets le titre de }'article indique dans la source d'ou la refe­ rence est tiree. Les references sont numerotees dans l'ordre alphabetique des noms d'auteurs. La liste est suivie d'un index par matieres et par pays, etabli en anglais et en franc;:ais. Les rubriques de l'index ont ete choisies par un groupe international d'experts en helminthiases. Les preparations pharma­ ceutiques sont designees le plus souvent dans l'index sous le nom qu'elles portent dans la Lisle recapitulative des denominations communes internatio­ nales proposees pour les preparations pharmaceutiques, Geneve, Organisa­ tion mondiale de la Sante, 1962. -9- PRINCIPAL SOURCES CONSULTED SOURCES PRINCIPALES CONSULTEES Armed Forces Medical Library Catalog (Washington) Bibliografia Brasileira de Medicina (Rio de Janeiro) Bibliografia Medica Venezolana (Caracas) Bibliography of Agriculture (Washington) Bibliography of Scientific Publications of South and South East Asia (New Delhi) Boletin del Centro de Documentaci6n Cientifica y Tecnica de Mexico. Secci6n 4 (Mexico) Bulletin de l'Institut Pasteur (Paris) Chinese Medical Journal. Current Chinese Medical Literature (Peking) Current List of Medical Literature (Washington) Documentation Bulletin of the National Research Centre. Abstracts of Scientific and Technical Papers Published in U.A.R. and Papers Received from Mghanistan, Cyprus, Iran, Iraq, Jordan, Lebanon, Pakistan, Saudi Arabia and Sudan (Cairo) Excerpta Medica. Section 17 (Amsterdam) Helminthological Abstracts (Famham Royal) Index-Catalogue of the Library of the Surgeon-General's Office (Washington) Index-Catalogue of Medical and Veterinary Zoology (Washington) Index Medicus (New York) Index Medicus (Washington) Index Veterinarius (Famham Royal) Japan Science Review. Medical Sciences (Tokyo) Japanese Periodicals Index. Natural Sciences (Tokyo) Medicinskaja Parazitologija i Parazitamye Bolezni (Moskva) National Library of Medicine Catalog (Washington) Quarterly Cumulative Index Medicus (Chicago) Tropical Diseases Bulletin (London) Veterinary Bulletin (Farnham Royal) Zentralblatt fUr Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. I. Abteilung. Referate (Stuttgart) Zoological Record (London) -10- 1. AABERG, M. E. 10. ABULADZE, T. E. Ancylostomiasis and hypoproteinemia com­ Sostojanie nekotoryh funkcij pt:Ceni pri anki­ plicated by pregnancy. Amer. J. Obstet. Gynec. lostomidoze [Na Gruzinskom jazyke]. In: 1946, 52, 854-857 Plan rabot i tezisy dokladov XV naucnoj sessii i ABADIE, S. H. V. 3705 Instituta medicinskoj parazitologii tropiceskoj medicini imeni S. S. Virsaladze, (Tbilisi), ABATE, J. DE V. 2121 1961, 27-28 ABBADIE, A. U. V. URRIBARI ABBADIE, A. 11. ACHARYA, S. K. 2. ABBOIT, 0. D. Incidence of helminth parasites in pariah The effect of improved diet on children with dogs. Indian vet. J. 1933, 9, 210 a moderate degree of hookworm infection. 12. ACHARYA, S. K. J. Home Economics, 1934, 26, 577-580 Incidence of helminth parasites in indigenous 3. ABDALLA, A. dogs and jackals with special reference to Avitaminosis B 1 in ancylostoma
Recommended publications
  • Human Ascariasis and Trichuriasis in Mazandaran Province, Northern Iran

    Human Ascariasis and Trichuriasis in Mazandaran Province, Northern Iran

    Environmental Health Engineering and Management Journal 2017, 4(1), 1–6 doi 10.15171/EHEM.2017.01 http://ehemj.com Environmental Health H E M J Engineering and Management Journal Review Article Open Access Publish Free Geohelminthic: human ascariasis and trichuriasis in Mazandaran province, northern Iran Hajar Ziaei1, Fatemeh Sayyahi2, Mahboobeh Hoseiny3, Mohammad Vahedi4, Shirzad Gholami5* 1Associate Professor, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran 2Medical Student, Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran 3MSC Statistic, GIS Research Center, Mazandaran University of Medical Sciences, Sari, Iran 4MSC Microbiology, Faculty Member, Department of Microbiology, Mazandaran University of Medical Sciences, Sari, Iran 5Associate Professor, Molecular and Cell Biology Research Center, Department of Parasitology and Mycology, Mazandaran University of Medical Sciences, Sari, Iran Abstract Article History: Background: Ascariasis and trichuriasis are the most common intestinal geohelminthic diseases, and Received: 21 October 2015 as such they are significant in terms of clinical and public health. This study was done to determine Accepted: 8 January 2016 prevalence, status and geographic distribution patterns for Ascariasis and Trichuriasis. The study was ePublished: 5 February 2016 done in the period 1991-2014 in northern Iran using Aregis 9.2 software. Methods: This was a review study, using description and analysis, of geographical distribution of Ascaris and Trichuris relating to townships in Mazandran province, northern Iran, covering a 23-year period. Data were collected from a review of the relevant literature, summarized and classified using Arc GIS, 9.2 to design maps and tables. Results: Based on results presented in tables and maps, means for prevalence of Ascaris and Trichuris were divided into five groups.
  • Hookworm (Ancylostomiasis)

    Hookworm (Ancylostomiasis)

    Hookworm (ancylostomiasis) Hookworm (ancylostomiasis) rev Jan 2018 BASIC EPIDEMIOLOGY Infectious Agent Hookworm is a soil transmitted helminth. Human infections are caused by the nematode parasites Necator americanus and Ancylostoma duodenale. Transmission Transmission primarily occurs via direct contact with fecal contaminated soil. Soil becomes contaminated with eggs shed in the feces of an individual infected with hookworm. The eggs must incubate in the soil for several days before they become infectious and are able to be transmitted to another person. Oral transmission can sometimes occur from consuming improperly washed food grown or exposed to fecal contaminated soil. Transmission can also occur (rarely) between a mother and her fetus/infant via infected placental or mammary tissue. Incubation Period Eggs must incubate in the soil for 5-10 days before they mature into infectious filariform larvae that can penetrate the skin. Within the first 10 days following penetration of the skin filariform larvae will migrate to the lungs and occasionally cause respiratory symptoms. Three to five weeks after skin penetration the larvae will migrate to the intestinal tract where they will mature into an adult worm. Adult worms may live in the intestine for 1-5 years depending on the species. Communicability Human to human transmission of hookworm does NOT occur because part of the worm’s life cycle must be completed in soil before becoming infectious. However, vertical transmission of dormant filariform larvae can occur between a mother and neonate via contaminated breast milk. These dormant filariform larvae can remain within in a host for months to years. Soil contamination is perpetuated by fecal contamination from infected individuals who can shed eggs in feces for several years after infection.
  • Lecture 5: Emerging Parasitic Helminths Part 2: Tissue Nematodes

    Lecture 5: Emerging Parasitic Helminths Part 2: Tissue Nematodes

    Readings-Nematodes • Ch. 11 (pp. 290, 291-93, 295 [box 11.1], 304 [box 11.2]) • Lecture 5: Emerging Parasitic Ch.14 (p. 375, 367 [table 14.1]) Helminths part 2: Tissue Nematodes Matt Tucker, M.S., MSPH [email protected] HSC4933 Emerging Infectious Diseases HSC4933. Emerging Infectious Diseases 2 Monsters Inside Me Learning Objectives • Toxocariasis, larva migrans (Toxocara canis, dog hookworm): • Understand how visceral larval migrans, cutaneous larval migrans, and ocular larval migrans can occur Background: • Know basic attributes of tissue nematodes and be able to distinguish http://animal.discovery.com/invertebrates/monsters-inside- these nematodes from each other and also from other types of me/toxocariasis-toxocara-roundworm/ nematodes • Understand life cycles of tissue nematodes, noting similarities and Videos: http://animal.discovery.com/videos/monsters-inside- significant difference me-toxocariasis.html • Know infective stages, various hosts involved in a particular cycle • Be familiar with diagnostic criteria, epidemiology, pathogenicity, http://animal.discovery.com/videos/monsters-inside-me- &treatment toxocara-parasite.html • Identify locations in world where certain parasites exist • Note drugs (always available) that are used to treat parasites • Describe factors of tissue nematodes that can make them emerging infectious diseases • Be familiar with Dracunculiasis and status of eradication HSC4933. Emerging Infectious Diseases 3 HSC4933. Emerging Infectious Diseases 4 Lecture 5: On the Menu Problems with other hookworms • Cutaneous larva migrans or Visceral Tissue Nematodes larva migrans • Hookworms of other animals • Cutaneous Larva Migrans frequently fail to penetrate the human dermis (and beyond). • Visceral Larva Migrans – Ancylostoma braziliense (most common- in Gulf Coast and tropics), • Gnathostoma spp. Ancylostoma caninum, Ancylostoma “creeping eruption” ceylanicum, • Trichinella spiralis • They migrate through the epidermis leaving typical tracks • Dracunculus medinensis • Eosinophilic enteritis-emerging problem in Australia HSC4933.
  • Studies Show That Fecal Dx Antigen Tests Allow for Earlier Detection of More Intestinal Parasites

    Studies Show That Fecal Dx Antigen Tests Allow for Earlier Detection of More Intestinal Parasites

    Research update Studies show that Fecal Dx antigen tests allow for earlier detection of more intestinal parasites Antigen detection is commonly used today to diagnose Results heartworm and Giardia infections, and now it is available for In the 1,156 field fecal samples for the roundworm and hookworm additional parasites. IDEXX Reference Laboratories, as a leader study and the 1,000 field fecal samples for the whipworm study, in pet healthcare innovation, has developed immunoassays for egg-positive roundworm, hookworm, and whipworm results were the detection of hookworm, roundworm, and whipworm antigens noted in 23, 13, and 27 samples, respectively. In contrast, 26, 19, in feces of dogs and cats. These antigens are secreted from the and 35 samples were antigen positive for roundworm, hookworm, adult worm and are not present in their eggs, which allows for and whipworm. The T. canis ELISA detected T. cati coproantigen in detection of prepatent stages as well as the ability to overcome the feline samples. Fecal antigens detected more infections than did challenges of intermittent egg laying. Earlier detection during the fecal flotation. prepatent period will also reduce the frequency of environmental contamination with potentially infectious eggs. Roundworm Hookworm Whipworm Two recent papers describing the performance of the Fecal Dx™ antigen tests, enzyme-linked immunosorbent assays (ELISAs) Fecal flotation 23 13 27 developed by IDEXX for coproantigen detection of Trichuris vulpis, positive Ancylostoma caninum and Toxocara canis in dogs and Toxocara cati in cats, are summarized below. Fecal Dx antigen 26 19 35 • Enzyme-linked immunosorbent assay for coproantigen detection test positive of Trichuris vulpis in dogs1 • Enzyme-linked immunosorbent assays for coproantigen Table 1.
  • Pathophysiology and Gastrointestinal Impacts of Parasitic Helminths in Human Being

    Pathophysiology and Gastrointestinal Impacts of Parasitic Helminths in Human Being

    Research and Reviews on Healthcare: Open Access Journal DOI: 10.32474/RRHOAJ.2020.06.000226 ISSN: 2637-6679 Research Article Pathophysiology and Gastrointestinal Impacts of Parasitic Helminths in Human Being Firew Admasu Hailu1*, Geremew Tafesse1 and Tsion Admasu Hailu2 1Dilla University, College of Natural and Computational Sciences, Department of Biology, Dilla, Ethiopia 2Addis Ababa Medical and Business College, Addis Ababa, Ethiopia *Corresponding author: Firew Admasu Hailu, Dilla University, College of Natural and Computational Sciences, Department of Biology, Dilla, Ethiopia Received: November 05, 2020 Published: November 20, 2020 Abstract Introduction: This study mainly focus on the major pathologic manifestations of human gastrointestinal impacts of parasitic worms. Background: Helminthes and protozoan are human parasites that can infect gastrointestinal tract of humans beings and reside in intestinal wall. Protozoans are one celled microscopic, able to multiply in humans, contributes to their survival, permits serious infections, use one of the four main modes of transmission (direct, fecal-oral, vector-borne, and predator-prey) and also helminthes are necked multicellular organisms, referred as intestinal worms even though not all helminthes reside in intestines. However, in their adult form, helminthes cannot multiply in humans and able to survive in mammalian host for many years due to their ability to manipulate immune response. Objectives: The objectives of this study is to assess the main pathophysiology and gastrointestinal impacts of parasitic worms in human being. Methods: Both primary and secondary data were collected using direct observation, books and articles, and also analyzed quantitativelyResults and and conclusion: qualitatively Parasites following are standard organisms scientific living temporarily methods. in or on other organisms called host like human and other animals.
  • Public Health Significance of Intestinal Parasitic Infections*

    Public Health Significance of Intestinal Parasitic Infections*

    Articles in the Update series Les articles de la rubrique give a concise, authoritative, Le pointfournissent un bilan and up-to-date survey of concis et fiable de la situa- the present position in the tion actuelle dans les do- Update selectedfields, coveringmany maines consideres, couvrant different aspects of the de nombreux aspects des biomedical sciences and sciences biomedicales et de la , po n t , , public health. Most of santepublique. Laplupartde the articles are written by ces articles auront donc ete acknowledged experts on the redigeis par les specialistes subject. les plus autorises. Bulletin of the World Health Organization, 65 (5): 575-588 (1987) © World Health Organization 1987 Public health significance of intestinal parasitic infections* WHO EXPERT COMMITTEE' Intestinal parasitic infections are distributed virtually throughout the world, with high prevalence rates in many regions. Amoebiasis, ascariasis, hookworm infection and trichuriasis are among the ten most common infections in the world. Other parasitic infections such as abdominal angiostrongyliasis, intestinal capil- lariasis, and strongyloidiasis are of local or regional public health concern. The prevention and control of these infections are now more feasible than ever before owing to the discovery of safe and efficacious drugs, the improvement and sim- plification of some diagnostic procedures, and advances in parasite population biology. METHODS OF ASSESSMENT The amount of harm caused by intestinal parasitic infections to the health and welfare of individuals and communities depends on: (a) the parasite species; (b) the intensity and course of the infection; (c) the nature of the interactions between the parasite species and concurrent infections; (d) the nutritional and immunological status of the population; and (e) numerous socioeconomic factors.
  • Performance of Two Serodiagnostic Tests for Loiasis in A

    Performance of Two Serodiagnostic Tests for Loiasis in A

    Performance of two serodiagnostic tests for loiasis in a Non-Endemic area Federico Gobbi, Dora Buonfrate, Michel Boussinesq, Cédric Chesnais, Sébastien Pion, Ronaldo Silva, Lucia Moro, Paola Rodari, Francesca Tamarozzi, Marco Biamonte, et al. To cite this version: Federico Gobbi, Dora Buonfrate, Michel Boussinesq, Cédric Chesnais, Sébastien Pion, et al.. Perfor- mance of two serodiagnostic tests for loiasis in a Non-Endemic area. PLoS Neglected Tropical Dis- eases, Public Library of Science, 2020, 14 (5), pp.e0008187. 10.1371/journal.pntd.0008187. inserm- 02911633 HAL Id: inserm-02911633 https://www.hal.inserm.fr/inserm-02911633 Submitted on 4 Aug 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. PLOS NEGLECTED TROPICAL DISEASES RESEARCH ARTICLE Performance of two serodiagnostic tests for loiasis in a Non-Endemic area 1 1 2 2 Federico GobbiID *, Dora Buonfrate , Michel Boussinesq , Cedric B. Chesnais , 2 1 1 1 3 Sebastien D. Pion , Ronaldo Silva , Lucia Moro , Paola RodariID , Francesca Tamarozzi , Marco Biamonte4, Zeno Bisoffi1,5 1 IRCCS Sacro
  • Environmental Characteristics Around the Household and Their Association with Hookworm Infection in Rural Communities from Bahir Dar, Amhara Region, Ethiopia

    Environmental Characteristics Around the Household and Their Association with Hookworm Infection in Rural Communities from Bahir Dar, Amhara Region, Ethiopia

    RESEARCH ARTICLE Environmental characteristics around the household and their association with hookworm infection in rural communities from Bahir Dar, Amhara Region, Ethiopia Melaku Anegagrie1,2☯, SofõÂa Lanfri3,4☯, Aranzazu Amor Aramendia1,2, Carlos 3,5 2 2 4 MatõÂas ScavuzzoID , Zaida HerradorID , AgustõÂn BenitoID , Maria Victoria PeriagoID * 1 FundacioÂn Mundo Sano, Madrid, Spain, 2 National Centre for Tropical Medicine, Institute of Health Carlos III, Madrid, Spain, 3 Instituto de Altos Estudios Espaciales Mario Gulich, ComisioÂn Nacional de Actividades Espaciales, Universidad Nacional de CoÂrdoba, CoÂrdoba, Argentina, 4 FundacioÂn Mundo Sano, Buenos a1111111111 Aires, Argentina, 5 Consejo Nacional de Investigaciones CientõÂficas y TeÂcnicas (CONICET), Buenos Aires, a1111111111 Argentina a1111111111 ☯ These authors contributed equally to this work. a1111111111 * [email protected] a1111111111 Abstract OPEN ACCESS Soil-Transmitted Helminths (STH) are highly prevalent Neglected Tropical Disease in Ethio- pia, an estimated 26 million are infected. Geographic Information Systems and Remote Citation: Anegagrie M, Lanfri S, Aramendia AA, Scavuzzo CM, Herrador Z, Benito A, et al. (2021) Sensing (RS) technologies assist data mapping and analysis, and the prediction of the spa- Environmental characteristics around the tial distribution of infection in relation to environmental variables. The influence of socioeco- household and their association with hookworm nomic, environmental and soil characteristics on hookworm infection at the individual and infection in rural communities from Bahir Dar, household level is explored in order to identify spatial patterns of infection in rural villages Amhara Region, Ethiopia. PLoS Negl Trop Dis 15(6): e0009466. https://doi.org/10.1371/journal. from Zenzelema (Amhara region). Inhabitants greater than 5 years old were recruited in pntd.0009466 order to assess the presence of STH.
  • Ancylostoma Ceylanicum

    Ancylostoma Ceylanicum

    Wei et al. Parasites & Vectors (2016) 9:518 DOI 10.1186/s13071-016-1795-8 RESEARCH Open Access The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates Junfei Wei1, Ashish Damania1, Xin Gao2, Zhuyun Liu1, Rojelio Mejia1, Makedonka Mitreva2,3, Ulrich Strych1, Maria Elena Bottazzi1,4, Peter J. Hotez1,4 and Bin Zhan1* Abstract Background: The intestine of hookworms contains enzymes and proteins involved in the blood-feeding process of the parasite and is therefore a promising source of possible vaccine antigens. One such antigen, the hemoglobin-digesting intestinal aspartic protease known as Na-APR-1 from the human hookworm Necator americanus, is currently a lead candidate antigen in clinical trials, as is Na-GST-1 a heme-detoxifying glutathione S-transferase. Methods: In order to discover additional hookworm vaccine antigens, messenger RNA was obtained from the intestine of male hookworms, Ancylostoma ceylanicum, maintained in hamsters. RNA-seq was performed using Illumina high-throughput sequencing technology. The genes expressed in the hookworm intestine were compared with those expressed in the whole worm and those genes overexpressed in the parasite intestine transcriptome were further analyzed. Results: Among the lead transcripts identified were genes encoding for proteolytic enzymes including an A. ceylanicum APR-1, but the most common proteases were cysteine-, serine-, and metallo-proteases. Also in abundance were specific transporters of key breakdown metabolites, including amino acids, glucose, lipids, ions and water; detoxifying and heme-binding glutathione S-transferases; a family of cysteine-rich/antigen 5/pathogenesis-related 1 proteins (CAP) previously found in high abundance in parasitic nematodes; C-type lectins; and heat shock proteins.
  • Hookworm-Related Cutaneous Larva Migrans

    Hookworm-Related Cutaneous Larva Migrans

    326 Hookworm-Related Cutaneous Larva Migrans Patrick Hochedez , MD , and Eric Caumes , MD Département des Maladies Infectieuses et Tropicales, Hôpital Pitié-Salpêtrière, Paris, France DOI: 10.1111/j.1708-8305.2007.00148.x Downloaded from https://academic.oup.com/jtm/article/14/5/326/1808671 by guest on 27 September 2021 utaneous larva migrans (CLM) is the most fre- Risk factors for developing HrCLM have specifi - Cquent travel-associated skin disease of tropical cally been investigated in one outbreak in Canadian origin. 1,2 This dermatosis fi rst described as CLM by tourists: less frequent use of protective footwear Lee in 1874 was later attributed to the subcutane- while walking on the beach was signifi cantly associ- ous migration of Ancylostoma larvae by White and ated with a higher risk of developing the disease, Dove in 1929. 3,4 Since then, this skin disease has also with a risk ratio of 4. Moreover, affected patients been called creeping eruption, creeping verminous were somewhat younger than unaffected travelers dermatitis, sand worm eruption, or plumber ’ s itch, (36.9 vs 41.2 yr, p = 0.014). There was no correla- which adds to the confusion. It has been suggested tion between the reported amount of time spent on to name this disease hookworm-related cutaneous the beach and the risk of developing CLM. Consid- larva migrans (HrCLM).5 ering animals in the neighborhood, 90% of the Although frequent, this tropical dermatosis is travelers in that study reported seeing cats on the not suffi ciently well known by Western physicians, beach and around the hotel area, and only 1.5% and this can delay diagnosis and effective treatment.
  • Albendazole: a Review of Anthelmintic Efficacy and Safety in Humans

    Albendazole: a Review of Anthelmintic Efficacy and Safety in Humans

    S113 Albendazole: a review of anthelmintic efficacy and safety in humans J.HORTON* Therapeutics (Tropical Medicine), SmithKline Beecham International, Brentford, Middlesex, United Kingdom TW8 9BD This comprehensive review briefly describes the history and pharmacology of albendazole as an anthelminthic drug and presents detailed summaries of the efficacy and safety of albendazole’s use as an anthelminthic in humans. Cure rates and % egg reduction rates are presented from studies published through March 1998 both for the recommended single dose of 400 mg for hookworm (separately for Necator americanus and Ancylostoma duodenale when possible), Ascaris lumbricoides, Trichuris trichiura, and Enterobius vermicularis and, in separate tables, for doses other than a single dose of 400 mg. Overall cure rates are also presented separately for studies involving only children 2–15 years. Similar tables are also provided for the recommended dose of 400 mg per day for 3 days in Strongyloides stercoralis, Taenia spp. and Hymenolepis nana infections and separately for other dose regimens. The remarkable safety record involving more than several hundred million patient exposures over a 20 year period is also documented, both with data on adverse experiences occurring in clinical trials and with those in the published literature and\or spontaneously reported to the company. The incidence of side effects reported in the published literature is very low, with only gastrointestinal side effects occurring with an overall frequency of just "1%. Albendazole’s unique broad-spectrum activity is exemplified in the overall cure rates calculated from studies employing the recommended doses for hookworm (78% in 68 studies: 92% for A. duodenale in 23 studies and 75% for N.
  • Heterogeneity in Transmission Parameters of Hookworm Infection Within the Baseline Data from the TUMIKIA Study in Kenya James E

    Heterogeneity in Transmission Parameters of Hookworm Infection Within the Baseline Data from the TUMIKIA Study in Kenya James E

    Truscott et al. Parasites Vectors (2019) 12:442 https://doi.org/10.1186/s13071-019-3686-2 Parasites & Vectors RESEARCH Open Access Heterogeneity in transmission parameters of hookworm infection within the baseline data from the TUMIKIA study in Kenya James E. Truscott1,2,3*, Alison K. Ower1,2, Marleen Werkman1,2,3, Katherine Halliday3,4, William E. Oswald3,4, Paul M. Gichuki5, Carlos Mcharo5, Simon Brooker6, Sammy M. Njenga5, Charles Mwandariwo5, Judd L. Walson1,3,7, Rachel Pullan4 and Roy Anderson1,2,3 Abstract Background: As many countries with endemic soil-transmitted helminth (STH) burdens achieve high coverage levels of mass drug administration (MDA) to treat school-aged and pre-school-aged children, understanding the detailed efects of MDA on the epidemiology of STH infections is desirable in formulating future policies for morbidity and/or transmission control. Prevalence and mean intensity of infection are characterized by heterogeneity across a region, leading to uncertainty in the impact of MDA strategies. In this paper, we analyze this heterogeneity in terms of factors that govern the transmission dynamics of the parasite in the host population. Results: Using data from the TUMIKIA study in Kenya (cluster STH prevalence range at baseline: 0–63%), we esti- mated these parameters and their variability across 120 population clusters in the study region, using a simple para- site transmission model and Gibbs-sampling Monte Carlo Markov chain techniques. We observed great heterogeneity in R0 values, with estimates ranging from 1.23 to 3.27, while k-values (which vary inversely with the degree of parasite aggregation within the human host population) range from 0.007 to 0.29 in a positive association with increasing prevalence.