bioRxiv preprint doi: https://doi.org/10.1101/062034; this version posted July 8, 2016. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. Animals in the Zika virus life cycle: what to expect from megadiverse Latin American countries. Marina Galvão Bueno1*; Nádia Martinez1; Lívia Abdala1, Claudia Nunes Duarte dos Santos2; Marcia Chame1& 1. Fundação Oswaldo Cruz – Programa Institucional Biodiversidade e Saúde, Av. Brasil 4036, sala 214, Rio de Janeiro - RJ - 21.040-361, Brazil. 2. Laboratório de Virologia Molecular, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Rua Prof. Algacyr Munhoz Mader 3775, Curitiba – PR - 81350-010, Brazil. *Corresponding author Email:
[email protected] (MGB) &Second Corresponding author Email:
[email protected] (MC) bioRxiv preprint doi: https://doi.org/10.1101/062034; this version posted July 8, 2016. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. ABSTRACT Zika virus (ZIKV) was first isolated in 1947 in primates in Uganda, West Africa. The virus remained confined to the equatorial regions of Africa and Asia, cycling between infecting monkeys, arboreal mosquitoes, and occasional humans. The ZIKV Asiatic strain was probably introduced into Brazil in 2013. In the current critical human epidemic in the Americas, ZIKV is transmitted primarily by Aedes aegypti mosquitoes, especially where the human population density is combined with poor sanitation.