DUSP12 () IP-WB Antibody show distinct substrate specificities for various MAP Pair , different tissue distribution and subcellular localization, and different modes of inducibility of their Catalog Number: H00011266-PW2 expression by extracellular stimuli. This product is the human ortholog of the Regulation Status: For research use only (RUO) YVH1 . It is localized predominantly in the nucleus, and is novel in that it Product Description: This IP-WB antibody pair set contains, and is regulated by a domain. comes with one antibody for immunoprecipitation and [provided by RefSeq] another to detect the precipitated protein in western blot.

Reactivity: Human

Applications: IP-WB (See our web site product page for detailed applications information)

Protocols: See our web site at http://www.abnova.com/support/protocols.asp or product page for detailed protocols

Supplied Product: Antibody pair set content: 1. Antibody pair for IP: rabbit polyclonal anti-DUSP12 (300 ul) 2. Antibody pair for WB: mouse purified polyclonal anti-DUSP12 (50 ug)

Storage Instruction: Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.

Entrez GeneID: 11266

Gene Symbol: DUSP12

Gene Alias: DUSP1, YVH1

Gene Summary: The protein encoded by this gene is a member of the dual specificity subfamily. These inactivate their target kinases by dephosphorylating both the phosphoserine/ and phosphotyrosine residues. They negatively regulate members of the -activated protein (MAP) superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases

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