DOCSLIB.ORG

May 23, 1972, NIH Record, Vol. XXIV, No. 11

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
May 23, 1972, NIH Record, Vol. XXIV, No. 11 the U. S. DEPARTMENT OF >May 23 , 197Record2 NATIONAL INSTITUTES OF HEALTH HEALTH, EDUCATION, AND WELFARE Vol. XXIV, No. 11 Research Teams Establish New Approach NIEHS Role Is Evaluated Medical Award Presented To the Study of Genetic Blood Diseases At Congressional Hearing To Dr. Makio Murayama Three teams of scientists participating in the Special Virus Cancer Program of the National Cancer Institute, have successfully reversed For Sickle Cell Studies the normal flow of genetic activity among fundamental cell chemicals to The Rev. Dr. Martin Luther permit reconstruction of a portion King, Jr. Medical Achievement of the gene for red blood cell Award will be presented to Dr. Two Framingham Study protein. Makio Murayama, the National In- Their findings establish a new stitute of Arthritis and Metabolic Directors Receive First approach to the study of genetic Diseases' noted sickle cell anemia diseases of the blood such as researcher. Eleanor Dana Award thalassemia. The award, which highlights Dr. One team, made up of NIH sci- Murayama's research in elucidat- Drs. William B. Kannel and entists reported their results in a ing the molecular concept of sick- Thomas R. Dawber, Director and recent issue of the Proceedings of ling, will be given to the researcher former Director, respectively, of the National Academy of Sciences. at a May 31st banquet. Noted NHLI's Framingham Heart Disease The researchers are Drs. Jeffrey guests who are expected at the Epidemiology Study, are co-recipi- Ross and Edward Scolnick of NCI's banquet include Aretha Franklin, ents of the American Health Foun- Viral Leukemia and Lymphoma Bill Cosby, Ossie Davis, and Count Branch, and Drs. Haim Aviv and Basie. Philip Leder, National Institute of Dr. Murayama will be honored Child Health and Human Develop- with other award recipients at the ment. Rep. Fountain (foreground). Dr. Rail award banquet to be held in the The other two groups, from the (I), Rep. William Alexander (D-Ark.), and Dr. D. C. Goldberg (r), professional Philadelphia Civic Center, Conven- Massachusetts Institute of Tech- staff member of the Subcommittee, tion Hall. The banquet is spon- nology and the Institute of Cancer view tissue cultures being studied by sored by the Philadelphia Chapter Research and College of Physicians the NIEHS Mutagenesis Branch. of the Southern Christian Leader- and Surgeons, Columbia Univer- ship Conference. sity, reported their findings in the The Intergovernmental Relations Co-chairmen are Pennsylvania journal, Nature New Biology. Their Subcommittee of the House Com- Governor Milton J. Shapp and Mu- Dr. Kannel Dr. Dawber research is supported in part by mittee on Government Operations hammad Ali. Philadelphia Mayor NIH. held a hearing on April 24 in Frank L. Rizzo and Rev. Ralph dation's first Eleanor Dana Award In their initial experiments with Raleigh, N.C., on the role of the David Abernathy are acting as for 1971 for ". significant con- rabbit cells, the scientists purified National Institute of Environmental honorary chairmen. tributions in the field of preventive a messenger RNA which directs Health Sciences with respect to Through the efforts of Dr. Mura- medicine." environmental problems which may production of globin, the protein (Continued on Page 5) The citation and $5,000 prize part of the hemoglobin or red endanger the Nation's health. were presented in April during an blood cells. Rep. L. H. Fountain (D-N.C), award luncheon that also opened Later, they applied the method conducted the hearing to learn how the AHF's Health Maintenance to experiments with human mes- the Institute relates to other gov- Institute. senger RNA. ernmental agencies in the same (See RESEARCH TEAMS, Page 4) field and to discuss scientific knowl- Dr. Dawber, associate professor edge and capabilities needed to of Medicine at Boston University combat environmental hazards. Medical Center, was Director of the Framingham Heart Study from Dr. Marston to Be Inducted "During the past year, the Sub- 1950 to 1966. In Honorary Hopkins Society committee has intensively studied Dr. Kannel joined the study as On May 26 NIH Director the potential dangers from chemi- deputy director in 1957, and has Dr. Robert Q. Marston will cal additives and drug residues in been Director of the study since be inducted into The Johns our food supply," Congressman 1966. Hopkins Society of Scholars Fountain disclosed. in ceremonies to be held at Dr. Robert Q. Marston, Director Gives Long-Term Look the university in Baltimore. of NIH, welcomed the group. The Framingham Study is a long- The Society was established In discussing his Institute's role, term prospective look into consti- 4 years ago to honor dis- Dr. David P. Rail, NIEHS Di- tutional and environmental factors tinguished, former postdoc- rector, said, "Our primary task is involved in the development and toral fellows of the univer- performing the basic biomedical progression of heart disease in a sity. research needed in the environ- general population sample (more Those elected to member- mental health field. When Dr. Frank J. Rauscher, Jr. took than 5,000 residents) of a typical ship must have "gained "We seek to provide the informa- the oath of office as Director of the American city, Framingham, Mass. marked distinction in their National Cancer Institute in a White tion necessary to insure that the House ceremony May 5, President By identifying major risk factors fields of scholarly or profes- environment is as free as possible Nixon told him he "must put in an in coronary heart disease, hyper- sional interest." from dangerous concentrations of 18- to 20-hour day" in search of a (SeeDANA AWARDEES, Page 6) (See NIEES ROLE, Page 7) cancer cure. Page 2 May 23, 1972 THE NIH RECORD Dr. Esfep Tells Scope of DRS Activities, Wtecord Extols Employees Skills in Research Aid Published biweekly at Bethesda, Md., by the Publications and Reports Branch, Office of Information, for the information of employees of the National Institutes of Health, Department of Health, Education, and Welfare, and circulated by request to interested writers and to investi- gators in the field of biomedical and related research. The content is reprintable without permission. Pictures are available on request. The NIH Record reserves the right to make corrections, changes or dele- tions in submitted copy in conformity with the policies of the paper and the Department of Health, Education, and Welfare. NIH Record Office Bldg. 31, Rm. 2B-03. Phone 49-62125 Editor Frances W. Davis Assistant Editor Fay Leviero Staff Writer Ed Driscoll Staff Correspondents ADA, Robert Manning; BHME/OD, Florence Foelak; CC, Ann Bain- bridge; DAHM, Laura Mae Kress; DBS, Faye Peterson; DCRT, Joan Chase; DDH, Carolyn Niblett; DMI, Marian R. Fox; DN, Evelyn Laz- zari; DPHPE, Eleanor Wesolowski; DRG, Sue Meadows; DRR, Jerry Gordon; DRS, Robert Knickerbocker; FIC, Lois P. Meng; NCI, Eliza- At the end of a seminar. Dr. Estep meets with co-workers and chats informally beth Shollenberger; NEI, Bonnie Friedman; NHLI, Bill Sanders; NIAID, about goals and ". effective communications among all employees . ." Krin Larson; NIAMD, Katie Broberg; NICHD, Lloyd Blevins; NIDR, A series of "get acquainted" seminars were held by Dr. Roger Estep, Sue Hannon; NIEHS, Elizabeth Y. James; NIGMS, Wanda Warddell; Director, Division of Research Services, with DRS employees. NINDS, Anne Tisiker; NLM, Roger Gilkeson. Four seminars were held in Wilson Hall, and the fifth was held at the NIH Animal Center in Poolesville. __^ The five DRS Branches were Eligible Employees May Apply were underway to refine the DRS Dick Gregory Visits NIH; represented in each of the 85 mem- training program. Last year that In Person for College on Campus ber groups. The seminars featured program provided 17,000 hours of Speaks Out Against War Upward Mobility College on the color slides emphasizing the skills employee training, 11,000 of which and diversified services provided On May 4 some 500 NIH em- NIH campus, is accepting applica- were at colleges, universities, and tions for the 1972-73 school year. by DRS in support of NIH re- private firms. ployees gave up their lunch hour to UMC, a part of Federal City Col- search. A color motion picture tell- hear Dick Gregory call for an end ing about the NIH Animal Center He also announced plans for lege, is offering two types of de- smaller, more personalized sem- to the Vietnam war. grees, an, Associate of Arts de- was also shown. The thin comedian, who has not gree and a bachelor's degree. After the presentation, many em- inars which would emphasize su- eaten solid food for 54 weeks in The college has an open admis- ployees said they had not fully re- pervisory responsibilities, employee protest, said he would continue his sions policy for employees meet- alized or appreciated the variety of rights, and employee services pro- fast until the conflict was over. ing eligibility requirements. Ap- research support DRS gives to the vided by the personnel office. He spanned subjects ranging plications will be accepted—in per- scientific community on the campus. Good Management Explained from the 1968 Democratic national son only—in Room B2B15, Bldg. 31. Dr. Estep termed DRS employees In his comments on the seminars, convention in Chicago to racism, its most important resource. He Dr. Estep said, "Good management and good performance begin with * sprinkling his remarks with sharp Dr. Martin Cummings Honored said the meetings were called in humor. order for him to share his aspira- clear, reliable communications. Dr. Martin M. Cummings, Di- "In an organization as diversified In conclusion, Mr. Gregory advo- tions, and to seek help in achieving rector of the National Library of common goals. At the close of the ... as DRS, effective communica- cated an economic boycott which he Medicine, will be awarded an hon- tions among all employees are es- said could end the war in 30 days.
Load more

Recommended publications
  • United States Patent (19) 11 Patent Number: 4,871,835 Aviv Et Al
    United States Patent (19) 11 Patent Number: 4,871,835 Aviv et al. (45) Date of Patent: Oct. 3, 1989 54 ANALOGS OF HGH HAVING Lewis et al., Biochem. Biophys, Res. Comm., 92(2), 1980, ANTAGONISTIC ACTIVITY, AND USES pp. 511-516. THEREOF DeGeeter, CA, vol. 99, 1983, #157232u. Russell et al., JBC, 256, 1981, pp. 296-300. (75) Inventors: Haim Aviv; Marian Gorecki, both of Lewis et al., JBC, 253(8), 1978, pp. 2679-2687. Rehovot; Avigdor Levanon, Netania; Goeddel et al., Nature, 281, 1979, pp. 544-548. Amos Oppenheim, Jerusalem; Tikva Seebury et al., Nature, 276, 1978, pp. 795-798. Vogel, Rehovot; Pinhas E. Zeelon, Ross et al., Hormone Design, 1982, pp. 313-318. Hashiva; Menachen Zeevi, Ramat Arieh Gertler et al., Endocrinology, 116(4): 1636-1644 Gan, all of Israel (1985). Alejandro C. Paladini et al., CRC Critical Reviews in 73) Assignee: Bio-Technology General Corp., New Biochemistry, 15(1): 25-56. York, N.Y. Primary Examiner-J. R. Brown 21 Appl. No.: 691,230 Assistant Examiner-Garnette D. Draper Attorney, Agent, or Firm-John P. White 22 Filed: Jan. 14, 1985 57 ABSTRACT Related U.S. Application Data Analogs of hCGH having the activity of naturally occur ring hCH and a similar amino acid sequence varying 63 Continuation-in-part of Ser. No. 514,188, Jul. 15, 1983. from the sequence of natural hCGh by the addition of one or more amino acids, e.g. methione or methionine-leu 511 Int. Cl." .............................................. CO7K 13/00 cine, to the N-terminus of natural hCGH have been pro 52 U.S.
    [Show full text]
  • Alvin Toffler
    A Bantam Book I published in association with William Morrow & Co., Inc. PRINTING HISTORY William Morrow edition published March 1980 5 printings September 1980 A Literary Guild Selection October 1979 A Selection of Preferred Choice Bookplan October 1979 and the Macmillan Book Club May 1980. Serialized in Industry Week, February 1980; East/West Network, February 1980; Across the Board, March 1980; Independent News Alliance, March 1980; Rotarian, April 1980; Mechanix Illustrated, May 1980; Reader's Digest, May 1980; Video Review, May 1980; Journal of Insurance, July 1980; Reader's Digest (Canada), August 1980; and Modern Office Procedures, September 1980. Bantam edition /April 1981 13 printings through May 1989 THE THIRD WAVE also appears in translation: French (Editions Deneol); German (Bertelsmann); Japanese (NHK Books); Spanish (Plaza y Janes and Editorial Diana); Danish (Chr. Erichsens Forlag); Dutch (Uilgenerij L.J. Veen); Hebrew (Am Oved); Portuguese (Distribuidora Record); Serbo-Croatian (Jugoslavia); Swedish) (Esselte Info AB); Turkish (Altin Kitaplar); Chinese (Dushu-Peking); U.K. (William Collins & Sons); India (Pan Books); Greece (Edition Cactus); Poland (Pantswowy Instytut Wydawniczy); Romania (Editura Politica); Portuguese (Livros do Brazil); Indonesia (P.T. Pantja Simpati); Korea (Korean Economic Daily). All rights reserved. Copyright © 1980 by Alvin Toffler. Cover art copyright © 1981 by Bantam Books. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the publisher. For information address: Bantam Books. ISBN 0-553-24698-4 Published simultaneously in the United States and Canada Bantam Books are published by Bantam Books, a division of Bantam Doubleday Dell Publishing Group, Inc.
    [Show full text]
  • Israeli Biotechnology Strategy Project Realizing Our Potential
    Israeli Biotechnology Strategy Project *** Realizing Our Potential Final Report Tel Aviv, March 2001 Submitted to The Chief Scientist, Ministry of Industry and Trade The Ministry of Finance The IBO by Amsterdam Athens Cambridge Frankfurt Hong Kong Istanbul Johannesburg London Los Angeles Madrid Manila Milan Moscow Munich New Delhi New York Paris S?o Paulo Seoul Singapore Stockholm Tel Aviv Tokyo Toronto Zurich Content A. INTRODUCTION..................................................................................................3 B. EXECUTIVE SUMMARY ....................................................................................4 C. GLOBAL TRENDS AND POTENTIAL FOR ISRAEL ..................................13 D. KEY ISSUES IDENTIFIED IN ISRAEL AND BENCHMARK OF FOREIGN CLUSTERS .......................................................................................23 E. AREAS OF RECOMMENDATIONS ................................................................40 F. CONCLUSION- LONG TERM OBJECTIVES FOR ISRAEL.......................58 G. GLOSSARY OF TERMS....................................................................................59 H. LIST OF INTERVIEWEES................................................................................60 I. BIBLIOGRAPHY..................................................................................................63 APPENDIX .................................................................................................................66 Page 2 /80– March 2001 © 2001 Monitor Company, Inc Introduction
    [Show full text]
  • Galactosidase Gene Arie Rosner, Marian Gorecki *, and Haim Aviv Departments of Virology and Organic Chemistry*, Weizmann Institute of Science, Rehovot, Israel, 76100
    Screening for Highly Active Plasmid Promoters via Fusion to /?-Galactosidase Gene Arie Rosner, Marian Gorecki *, and Haim Aviv Departments of Virology and Organic Chemistry*, Weizmann Institute of Science, Rehovot, Israel, 76100 Z. Naturforsch. 37 c, 441 —444 (1982); received January 13, 1982 Plasmid Promoter, /?-Galactosidase Gene, Escherichia coli A plasmid containing promoter-deleted inactive /?-galactosidase gene [1] was used to select promoters of the pEP121 plasmid [2]. Colonies of cells harboring reactivated /?-galactosidase gene were identified by their red color on McConkey plates. The quantitative amounts of /?-galactosidase produced in each clone were estimated by assaying enzyme activity and by measuring the specific /?-galactosidase protein following fractionation of total cells’ proteins on polyacrylamide gel. A wide range of enzyme activities was observed. The most active promoter isolated was shown to promote /?-galactosidase production more efficiently, compared with the original /?-galactosidase promoter, amounting to 20% of all cell proteins. Such highly active promoters may be utilized in the future, to promote expression of cloned genes in bacteria. Introduction gene and E. coli strain MC 1061, restriction minus, deleted in the lactoase operon [1] were received It was previously shown that bacterial promoters from Dr. M. J. Casadaban and given to us by Dr. M. can promote expression of foreign genes in bacteria Mevorach. [3, 4]. The amount of protein produced depends Preparation of plasmid: Extraction of plasmid mainly on the activity of the promoter itself. The DNA was performed according to Betlach et al. [5]. isolation and molecular manipulation of bacterial Transformation of cells with plasmid DNA was promoters became, therefore, of prime interest in carried out as described by Cohen et al.
    [Show full text]
  • Accelerating Medical Solutions in Israel: Building a Global Life Science Industry
    Volume 6 May 2008 May Financial Innovations Lab Report Lab Innovations Financial Accelerating Medical Solutions in Israel: Building a Global Life Science Industry FINANCIAL INNOVATIONS LAB REPORT Volume 6 May 2008 May Financial Innovations Lab Report Lab Innovations Financial Accelerating Medical Solutions in Israel: Building a Global Life Science Industry FINANCIAL INNOVATIONS LAB REPORT Acknowledgments This "Financial Innovations Lab Report for Accelerating The Israel Presidential Conference "Facing Tomorrow" will Medical Solutions in Israel: Building a Global Life Science be dedicating a special session to the translation of medical Industry" was prepared by Glenn Yago, Ronit Purian-Lukatch innovation in Israel into business success, based on the and Ilan Vaknin. Liza Ireni-Saban drafted Appendix 1 on current report. We thank President Shimon Peres for his regulation and legislation concerning clinical and genetic vision and inspiration of the process whereby the Financial trials. We are grateful to all participants of the Financial Innovations Lab took place. Innovations Lab and workgroups for their contributions to the ideas summarized in this report. A list of participants may be found in Appendix 2. We give special thanks to the Sacta-Rashi Fund and the Yeshaya Horowitz Foundation for their interest and continuing support of this work. The Milken Institute is an independent economic think tank whose mission is to improve the lives and economic conditions of diverse populations in the US and around the world by helping business
    [Show full text]
  • Galactosidase Gene Arie Rosner, Marian Gorecki *, and Haim Aviv Departments of Virology and Organic Chemistry*, Weizmann Institute of Science, Rehovot, Israel, 76100
    Screening for Highly Active Plasmid Promoters via Fusion to /?-Galactosidase Gene Arie Rosner, Marian Gorecki *, and Haim Aviv Departments of Virology and Organic Chemistry*, Weizmann Institute of Science, Rehovot, Israel, 76100 Z. Naturforsch. 37 c, 441 —444 (1982); received January 13, 1982 Plasmid Promoter, /?-Galactosidase Gene, Escherichia coli A plasmid containing promoter-deleted inactive /?-galactosidase gene [1] was used to select promoters of the pEP121 plasmid [2]. Colonies of cells harboring reactivated /?-galactosidase gene were identified by their red color on McConkey plates. The quantitative amounts of /?-galactosidase produced in each clone were estimated by assaying enzyme activity and by measuring the specific /?-galactosidase protein following fractionation of total cells’ proteins on polyacrylamide gel. A wide range of enzyme activities was observed. The most active promoter isolated was shown to promote /?-galactosidase production more efficiently, compared with the original /?-galactosidase promoter, amounting to 20% of all cell proteins. Such highly active promoters may be utilized in the future, to promote expression of cloned genes in bacteria. Introduction gene and E. coli strain MC 1061, restriction minus, deleted in the lactoase operon [1] were received It was previously shown that bacterial promoters from Dr. M. J. Casadaban and given to us by Dr. M. can promote expression of foreign genes in bacteria Mevorach. [3, 4]. The amount of protein produced depends Preparation of plasmid: Extraction of plasmid mainly on the activity of the promoter itself. The DNA was performed according to Betlach et al. [5]. isolation and molecular manipulation of bacterial Transformation of cells with plasmid DNA was promoters became, therefore, of prime interest in carried out as described by Cohen et al.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,229,003 B1 Aviv Et Al
    USOO6229003B1 (12) United States Patent (10) Patent No.: US 6,229,003 B1 Aviv et al. (45) Date of Patent: May 8, 2001 (54) PRODUCTION OF BOVINE GROWTH OTHER PUBLICATIONS HORMONE BY MICROORGANISMS Seeburg et al., Nature 276:795–798 (1978). (75) Inventors: Haim Aviv, Rehovot; Eliyahu Keshet, Lingappa et al., Cell Biol. 74:2432-2436 (1977). Ramat; Marian Gorecki, Rehovot, Cohen et al., P.N.A.S. 70 (11):3240–3244 (1973); and. Chang et al., P.N.A.S. 71 (4): 1030-1034 (1974). Arie Rosner, Nes Ziona, all of (IL) Nilson et al. (1979), “Purificatio of Pre-prolactin mRNA (73) Assignee: Yeda Research and Development from Bovine Anterior Pituitary Glands”, J. Biol. Chem. Company Ltd., Rehovot (IL) 254:1516-1520. Keiichi Itakura and Arthur D. Riggs (1980), “Chemical (*) Notice: Subject to any disclaimer, the term of this DNA Synthesis and Recombinant DNA Studies”, Science patent is extended or adjusted under 35 209:1401-1405. U.S.C. 154(b) by 0 days. Hunt and Dayhoff (1976), Atlas of Protein Sequence and Structure, (National Biomed. Res. Fund.) Washington, D.C., Vol. 5, Supp. 2, p. 11. (21) Appl. No.: 08/457,405 Edge et al. (1981), “Total Synthesis Of A Human Leukocyte (22) Filed: Jun. 1, 1995 Interferon Gene”, Nature 292:756–762. Coutelle et al. (1978), “Use of Matrix-Immobilised Recom Related U.S. Application Data binant Plasmids To Purify Chain-Specific Rabbit Globin Complementary DNAs, Gene 3:113-122. (63) Continuation of application No. 08/317.248, filed on Oct. 3, 1994, now abandoned, which is a continuation of application Sassavage et al., Federation Proceedings, Abstracts, (1979), No.
    [Show full text]
  • Purification of Biologically Active Globin Messenger RNA By
    Proc. Nat. Acad. Sci. USA Vol. 69, No. 6, pp. 1408-1412, June 1972 Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose (p.ly (A)-richi inRNA/rabbit globin niRN A/ascites tumiior cell-free systelml) HAIM AVIV ANI) PHILIP LEI)ER Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014 Coinnmunicatel by E. IR. Stadtrnan, March 22, 1972 ABSTRACT A convenient technique for the partial MATERIALS AND METHODS purification of large quantities of functional, poly(adenylic acid)-rich mRNA is described. The method depends upon The sources of many of the reagents used in this study have annealing poly(adenylic acid)-rich mRNA to oligothymi- been indicated (10). For the synthesis of oligo(dT)-cellulose, dylic acid-cellulose columns and its elution with buffers Whatman cellulose powder CC 41 was obtained from Reeve of low ionic strength. Biologically active rabbit globin Angel; thymidine-5'-monophosphate, from Schwarz-Mann; mRNA has been purified by this procedure and assayed for its ability to direct the synthesis of rabbit globin in a and NN'-dicyclohexylearbodiimide, from Aldrich. [3H]- cell-free extract of ascites tumnor. Inasmuch as various Leucine (specific activity, 26 Ci/mmol); ['4C]leucine (specific mammalian mRNAs appear to be rich in poly(adenylic activity, 263 Ci/mol) and [14C]valine (specific activity, 219 acid) and can likely be translated in the ascites cell-free Ci/mol), from New England Nuclear; [14C]lysine (specific extract, this approach should prove generally useful as an i -itial step in the isolation of specific mRNAs.
    [Show full text]
  • President's Report 2018
    VISION COUNTING UP TO 50 President's Report 2018 Chairman’s Message 4 President’s Message 5 Senior Administration 6 BGU by the Numbers 8 Building BGU 14 Innovation for the Startup Nation 16 New & Noteworthy 20 From BGU to the World 40 President's Report Alumni Community 42 2018 Campus Life 46 Community Outreach 52 Recognizing Our Friends 57 Honorary Degrees 88 Board of Governors 93 Associates Organizations 96 BGU Nation Celebrate BGU’s role in the Israeli miracle Nurturing the Negev 12 Forging the Hi-Tech Nation 18 A Passion for Research 24 Harnessing the Desert 30 Defending the Nation 36 The Beer-Sheva Spirit 44 Cultivating Israeli Society 50 Produced by the Department of Publications and Media Relations Osnat Eitan, Director In coordination with the Department of Donor and Associates Affairs Jill Ben-Dor, Director Editor Elana Chipman Editorial Staff Ehud Zion Waldoks, Jacqueline Watson-Alloun, Angie Zamir Production Noa Fisherman Photos Dani Machlis Concept and Design www.Image2u.co.il 4 President's Report 2018 Ben-Gurion University of the Negev - BGU Nation 5 From the From the Chairman President Israel’s first Prime Minister, David Ben–Gurion, said:“Only Apartments Program, it is worth noting that there are 73 This year we are celebrating Israel’s 70th anniversary and Program has been studied and reproduced around through a united effort by the State … by a people ready “Open Apartments” in Beer-Sheva’s neighborhoods, where acknowledging our contributions to the State of Israel, the the world and our students are an inspiration to their for a great voluntary effort, by a youth bold in spirit and students live and actively engage with the local community Negev, and the world, even as we count up to our own neighbors, encouraging them and helping them strive for a inspired by creative heroism, by scientists liberated from the through various cultural and educational activities.
    [Show full text]
  • United States Patent 19 11 Patent Number: 5,716,637 Anselem Et Al
    US005716637A United States Patent 19 11 Patent Number: 5,716,637 Anselem et al. 45 Date of Patent: *Feb. 10, 1998 54 SOLID FAT NANOEMULSIONS AS WACCNE 56) References Cited DELVERY WEHICLES U.S. PATENT DOCUMENTS Inventors: Shimon Anselem, Rehovot, Israel; 4,880,635 11/1989 Janoff...................................... 424/450 George H. Lowell, Baltimore, Md.; 5,023,271 6/1991 Vigne ... 514/.458 Haim Aviv, Rehovot; Doron 5,171,737 12/1992 Weiner ........................................ 514/3 Friedman, Carmei Yosef, both of Israel 5,188,837 2/1993 Domb ..... 424/450 5,284.663 2/1994 Speaker ...... 424/489 73) Assignees: Pharmos Corporation, New York, 5,302.401 4/1994 Livesidge ... 424/489 N.Y.; The United States of America as 5,306,508 4/1994 Kossovsky . 424/493 represented by the Secretary of the 5,308,624 5/1994 Maircent ... 424/427 Army, Washington, D.C. 5,576,016 11/1996 Amselem ................................ 424/450 FOREIGN PATENT DOCUMENTS * Notice: The term of this patent shall not extend 0315079 5/1989 European Pat. Off.. beyond the expiration date of Pat. No. 0506 197 9/1992 European Pat. Off.. 5,576,016. WO91/07171 5/1991 WIPO. 21 Appl. No.: 553,350 OTHER PUBLICATIONS CRC Press, Inc., Liposome Technology, 2nd Edition, vol. 1, 22 PCT Filled: May 18, 1994 Chapter 28, p. 501, Liposome Preparation and Related Techniques, edited by Gregory Gregoiadis, Ph.D., "A 86 PCT No.: PCT/US94/05589 Large-Scale Method For the Preparation. Of Sterile And Nonpyrogenic Liposomal Formulations Of Defined Size S371 Date: Nov. 16, 1995 Distributions For Clinical Use'.
    [Show full text]
  • High-Level Expression of Enzymatically Active Human Cu/Zn Superoxide Dismutase in Escherichia Coli (Bacterial Expression Vector/A PL/Ribosome Binding Site) JACOB R
    Proc. Natl. Acad. Sci. USA Vol. 83, pp. 7142-7146, October 1986 Biochemistry High-level expression of enzymatically active human Cu/Zn superoxide dismutase in Escherichia coli (bacterial expression vector/A PL/ribosome binding site) JACOB R. HARTMAN, TANIA GELLER, ZIVA YAVIN, DANIEL BARTFELD, Dov KANNER, HAIM Aviv, AND MARIAN GORECKI Bio-Technology General (Israel) Ltd., Kiryat Weizmann, Rehovot 76326 Israel Communicated by Richard Axel, May 13, 1986 ABSTRACT Expression of human Cu/Zn superoxide dis- interest has evolved in the therapeutic potential of SOD. A mutase (SOD) with activity comparable to the human eryth- wide range of clinical applications has been suggested. These rocyte enzyme was achieved in Escherichwa coli by using a include prevention of oncogenesis and tumor promotion, vector containing a thermoinducible X PL promoter and a reduction of the cytotoxic and cardiotoxic effects of ,8-lactamase-derived ribosomosal binding site. The recombi- anticancer drugs (5), anti-inflammatory action (6), and pro- nant human SOD was found in the cytosol ofdisrupted bacteria tection against reperfusion damage of ischemic tissues (7). In and represented >10% of the total bacterial protein. The addition, there is much interest in studying the effects ofSOD enzyme was purified to homogeneity by salt precipitation, gel on the aging process (8). filtration chromatography, and ion exchange chromatography. The exploration ofthe therapeutic potential ofhuman SOD The active enzyme was obtained in high yield only when 1 mol has been hindered by its limited availability. The enzyme is of copper and 1 mol of zinc were incorporated into each mol of a dimeric metalloprotein composed of identical noncovalent- subunit during bacterial growth or by reconstitution of the ly linked subunits, each of 16 kDa and containing one atom apoenzyme.
    [Show full text]
  • United States Patent [191 [11] Patent Number: 4,831,120 Aviv Et Al
    United States Patent [191 [11] Patent Number: 4,831,120 Aviv et al. [45] Date of Patent: May 16, 1989 [54] METHOD FOR RECOVERING A PURIFIED ANIMAL GROWTH HORMONE OR FOREIGN PATENT DOCUMENTS POLYPEPTIDE ANALOG THEREOF FROM 0061250 9/1982 European Pat. Off. A BACTERIAL CELL 0127305 12/1984 European Pat. Off. 2083824 3/1982 United Kingdom . [75] Inventors: Haim Aviv; Marian Gorecki, both of 8304418 12/ 1983 United Kingdom . Rehovot; Avigdor Levanon, Netania; 2138004 9/1984 United Kingdom . Amos Oppenheim, Jerusalem; Tikva Vogel, Rehovot; Elisha Zeelon, OTHER PUBLICATIONS Hashiva; Menachem Zeevi, Ramat Principles of Biochemistry, Lehninger 1982, p. 177. Gan, all of Israel Primary Examiner—Johnnie R. Brown [73] Assignee: Bio-Technology General Corp., New Assistant Examiner—Garnette D. Draper York, NY. Attorney, Agent, or Firm-John P. White [21] Appl. No.: 752,441 [57] ABSTRACT An improved vector upon introduction into a suitable [22] Filed: Jul. 3, 1985 bacterial host containing the thermolabile repressor C1 renders the host cell capable, upon increasing the tem Related U.S. Application Data perature of the host cell to a temperature at which the repressor is destroyed, of effecting expression of a de [63] Continuation of Ser. No. 514,188, Jul. 15, 1983, aban doned. sired gene inserted into the vector and production of polypeptide encoded by the gene. The vector is a dou [30] Foreign Application Priority Data ble-stranded DNA molecule which includes in 5' to 3’ order the following: a DNA sequence which contains Jul. 3, 1984 [EP] European Pat. Off. ...... .. 84107717.5 the promoter and operator PLOL from lambda bacterio [51] Int.
    [Show full text]