Serenx™ References Medicinal Ingredients (Per Vegetarian Capsule) 8:1 Proprietary Herbal Extract Blend 1

[8] [14] This in TCM. [11-13] genus of the [15] Salvia is considered very cold in mai men dong ) [16] , or Japanese sweet flag, has a or Japanese sweet flag, , ) (AG) may play a role in supporting is an ancient Chinese herb associated ) is known as ) is a member of the ) [18] genus have been used medicinally across is used as a general tonic to strengthen the ) is considered a valuable herb in TCM; it has been is considered a valuable herb in ) Salvia Acorus gramineus is a mushroom that has been used in TCM to “quiet TCM to is a mushroom that has been used in ) Acorus gramineus Animal studies suggest that the asarone essential oil in [17] Asparagus cochinchinensis Salvia miltiorrhiza [10] Panax ginseng Panax Ophiopogon japonicus has been used specifically for support of cerebrovascular health, has been used specifically for support of cerebrovascular health, Platycodon grandiflorum Angelica sinensis Poria wolfiporia Poria [9] family. Members of the family. Combination of Traditional Chinese Medicine ingredients Traditional Combination of Platycodon root ( maintenance of healthy capillary with increased tolerance to foreign irritants, and promotion of an inner sense of calm.* permeability, Grass-Leaf Sweetflag rhizome ( Contemporary Asia for supporting health and balance in the body. long history of use in research on herbs suggest that neuronal health and memory. effect.* neuroprotective AG has a specific, Don Quai root ( robust energyused for centuries to support female health and promote levels.* Chinese asparagus root ( and promote normal gastrointestinal (GI) nourish yin, It is used to moisten dryness, TCM. transit time.* Ophiopogon root ( promote patterns, is used to address healthy sleep often combined with others, herb, and promote support normal heart rhythm, a sense of calm and tolerance to stress, healthy energy levels.* Asian Ginseng root ( normal response the body’s It is used traditionally to support body and restore vitality. support neurological health and maintain robust energy and alertness, to stress, Ginseng stimulates the pituitary and promote healthy sleep patterns. to secrete balance, which stimulates adrenal activity.* adrenocorticotropic hormone (ACTH), Chinese salvia root ( Lamiaceae The root of a variety of cultures for their relaxing effect on the central nervous system. Salvia miltiorrhiza and liver and kidney health.* menstruation issues, healthy sleep patterns, Poria fungus ( and support healthy sleep patterns.* the heart and calm the spirit” • PATENTED •

[5]

™ [4] It has [1] , also called ,

[7] Scrophularia Biota seed

EXCLUSIVE [6] Scrophularia root ( is an extensively studied adaptogen used for and ) ) ™ Available in 120 capsules Available is used in TCM for sustaining a healthy appetite, supporting supporting TCM for sustaining a healthy appetite, is used in )

Rehmannia is among a select list of herbs that have been [2] Scrophularia is present to complement the positive effects of Rehmannia glutinosa Schisandra chinensis [3]

are two closely related herbs with similar supportive uses. Rehmannia related herbs with similar supportive uses. are two closely )

[5] Zizyphus spinosa SerenX oriental arborvitae seed, is combined in TCM with jujube and schisandra fruit to support TCM with jujube is combined in oriental arborvitae seed, and healthy sleep patterns.* normal heart rhythm, a sense of tranquility, Jujube ( and promoting a sense of inner calm. healthy energy levels, stimulating effect on the central nervous system, enhances learning and memory, and is enhances learning and memory, stimulating effect on the central nervous system, and gastroprotective. cardioprotective, hepatoprotective, considered neuroprotective, Human studies suggest it plays an effective role in supporting physical and mental stamina.* increasing energy and supporting the body’s natural resistance to stress. By definition, By definition, natural resistance to stress. increasing energy and supporting the body’s an adaptogen can decrease sensitivity to stressors while promoting stress resistance In vitro and animal studies suggest that schisandra has a and systemic equilibrium. Traditional Medicine, rehmannia and scrophularia are similar in their “cold” nature and “cold” rehmannia and scrophularia are similar in their Medicine, Traditional supplementation of adrenal chi.* including provide a number of similar benefits, Schisandra fruit ( officially for the support of blood glucose levels alreadyapproved in China within the normal range. director of the Institute for PhD, According to Subhuti Dharmananda, rehmannia. been used specifically to support adrenal function, hormone balance, and a healthy hormone balance, been used specifically to support adrenal function, invigorate herbalists utilize it to nourish yin, Chinese journey through menopause. and help the body adapt to and endure physical and restore vital force, the kidney, environmental stress. is a prized herb in TCM and an extensively studied plant in modern pharmacognosy. TCM and an extensively studied plant in modern pharmacognosy. is a prized herb in Research studies suggest that in the this valuable herb supports several vital systems and nervous systems. endocrine, immune, the cardiovascular, including body, circumstantial stressors that individuals may experience later in life.* Rehmannia root ( ningpoensis cultures to support health and well-being. The synergistic blend of herbs in SerenX The synergistic blend of cultures to support health and well-being. This blend has been Chinese Medicine (TCM). Traditional has a long history of use in face of everydayused for supporting peace of mind and serenity in the stressors and Discussion Herbs have and are used currently across a wide range of been used traditionally

XYMOGEN CANADA SerenX™ References Medicinal Ingredients (per vegetarian capsule) 8:1 Proprietary Herbal Extract Blend 1. Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry Rehmannia Root (Rehmannia glutinosa), Schisandra Fruit (Schisandra chinensis), Jujube Fruit (Ziziphus and pharmacology. J Ethnopharmacol. 2008 May 8;117(2):199-214. Review. ), Oriental Arborvitae Seed ( ), Chinese Asparagus Root ( ), jujuba Biota orientalis Asparagus cochinchinensis [PMID: 18407446] Ophiopogon Root (Ophiopogon japonicus), Scrophularia Root (Scrophularia ningpoensis), Dong Quai Root (Angelica sinensis), Asian Ginseng Root (Panax ginseng), Chinese Salvia Root (Salvia miltiorrhiza), Poria 2. Huang CH. The Pharmacology of Chinese Herbs. 2nd ed. New York, NY: CRC Fungus (Poria cocos), Platycodon Root (Platycodon grandiflorum), Grass-Leaf Sweetflag Rhizome Acorus( Press; 1999:264-65. gramineus) �� 500 mg 3. Jia W, Gao W, Tang L. Antidiabetic herbal drugs officially approved in China. Non-Medicinal Ingredients Phytother Res. 2003 Dec;17(10):1127-34. Review. [PMID: 14669243] HPMC (capsule), microcrystalline cellulose, medium-chain triglyceride oil, magnesium stearate, silica. 4. Dharmananda S. Rehmannia. March 1999. http://www.itmonline.org/arts/ Recommended Dose rehmann.htm. Accessed March 25, 2013. Adults: Take two capsules daily or as directed by your healthcare practitioner. For prolonged use, 5. Panossian A, Wikman G. Effects of adaptogens on the central nervous system consult a healthcare practitioner. and the molecular mechanisms associated with their stress-protective activity. Do not use if you are pregnant or breastfeeding. Consult a healthcare practitioner prior to use if Review. Pharmaceuticals. 2010;3(1):188-224. doi:10.3390/ph3010188. you are taking prescription medications. Avoid taking with cilantro, garlic, radishes, seafood and 6. Chen J, Chen T. Suan Zoa Ren. Chinese Medical Herbology and alcohol. Pharmacology. City of Industry, CA: Art of Medicine Press; 2004:762. May cause occasional side effects such as indigestion, epigastric fullness and distention, mild 7. Cheng R. Semen Biotae.TCM Basics website. http://www.tcmbasics.com/ diarrhea, skin rashes and itching. If symptoms persist or worsen, or if new symptoms develop, materiamedica/semen_biotae.htm. Accessed March 28, 2013. discontinue use and consult a healthcare practitioner. 8. Krinsky DL, LaValle JB, Hawkins EB, et al. Natural Therapeutics Pocket Guide. Does Not Contain: Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, 2nd ed. Hudson, OH: Lexi-Comp; 2003:426-7. tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives. 9. Chen J, Chen, T. Tian Men Dong. Chinese Medical Herbology and Pharmacology. City of Industry, CA: Art of Medicine Press; 2004:946. 10. Chen J, Chen, T. Tian Men Dong. Chinese Medical Herbology and Pharmacology. City of Industry, CA: Art of Medicine Press; 2004:943-5. 11. Chen J, Chen, T. Ren Shen. Chinese Medical Herbology and Pharmacology. City of Industry, CA: Art of Medicine Press; 2004:835-40. 12. Natural Standard Database. Ginseng. http://www.naturalstandard.com/ databases/herbssupplements/ginseng.asp?#undefined. Accessed March 26, 2013. 13. Natural Medicines Comprehensive Database. Ginseng, Panax. MedlinePlus. http://www.nlm.nih.gov/medlineplus/druginfo/natural/1000.html. Updated December 11, 2012. Accessed March 26, 2013. 14. Imanshahidi M, Hosseinzadeh H. The pharmacological effects of Salvia species on the central nervous system. Phytother Res. 2006 Jun;20(6):427-37. Review. [PMID: 16619340] 15. Poria – Wolfiporia extensa. Ottawa, Ontario: Health Canada: 2012. http:// webprod.hc-sc.gc.ca/nhpid-bdipsn/monoReq.do?id=839&lang=eng. Accessed March 28, 2013. 16. Chen J, Chen T. Jie Geng. Chinese Medical Herbology and Pharmacology. City of Industry, CA: Art of Medicine Press; 2004:696-7. 17. Jesky R, Hailong C. Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional Chinese medicines. Phytother Res. 2011 Aug;25(8):1105-18. Review. [PMID: 21305632] 18. Cho J, Kim YH, Kong JY, et al. Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus. Life Sci. 2002 Jun 21;71(5):591-9. [PMID: 12052443]

Additional references available upon request

EXCLUSIVE • PATENTED