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Mouse Chromosome 10

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Mouse Chromosome 10 Mammalian Genome 4, S 154--S 163 (1993). "~enome 9Springer-Verlag New York Inc. 1993 Mouse Chromosome 10 Benjamin A. Taylor, 1'* Wayne N. Frankel, 1 Margit Burmeister, 2 Elizabeth Bryda 3 IThe Jackson Laboratory, Bar Harbor, Maine 046.09, USA 2University of Michigan, Ann Arbor, Michigan 48109, USA 3Wadsworth Center for Laboratories and Research, Albany, New York 12201, USA Received: 2 June 1993 Introduction Table 2 shows the apparent gene order and recom- bination frequencies as estimated in seven different The 1993 Mouse Chromosome (Chr) I0 report includes multilocus crosses. In all seven, either Myb or Mpmv- the addition of new genes and other DNA variants, 12 and either Ifg or Mdrn-1 have been scored. Myb and their positions in the linkage and/or cytogenetic maps, Mpmv-12 are known to be closely linked (Frankel et deletions, recombinant inbred (RI) strain distribution al. 1990) as are Mdm-1 andlfg (Taylor et al. 1992). The patterns (SDPs), data pertaining to imprinting, and in- MIT intercross involving Mus castaneus has not been formation about human-mouse linkage homology. typed for these markers but has been typed for mark- New this year is a table showing the apparent gene ers known to be quite close to these markers. Thus, order and recombination frequencies as determined in DlOMit4 is known to be close to Mpmv-12 (and hence, multilocus crosses. Myb), and DlOMit14 is known to be close to Mdm-1 Table 1 lists known Chr 10 loci alphabetically by (Dietrich et al. 1992a; Taylor et al. 1992). These seven gene symbols. Additional columns are used to denote crosses include three interspecific crosses involving (a) loci added to the list since the last report, (b) loci Mus spretus and four intersubspecific crosses, two in- designated as reference loci, (c) the approximate map volving Mus castaneus and one each involving Mus position in centimorgans from the centromere (if musculus and Mus molossinus, and the pooled results known), (d) localization to specific chromosomal of two small backcrosses involving conventional bands, (e) classification of the loci (DNA, biochemi- strains C57BL/6J and A/J. The (Myb/Mpmv-12)- cal, visible, etc.), (f) the method(s) used in mapping, (Mdm-I/Ifg) two-point distance may be slightly under- (g) the gene symbol of the human homolog (if known), estimated in three of the crosses owing to undetected (h) the location of the human homolog, and (i) selected double crossovers between widely spaced markers. references pertaining to the mapping of the mouse Six of the cumulative distance estimates are quite con- gene. Formerly used locus symbols are also listed al- sistent with a mean of 56.1 (range: 48-64 cM). The phabetically within the table. Pasteur Mus spretus backcross (Cross B) gave a sub- stantially shorter map distance (40.7 cM). This is one of the smaller of the seven crosses in gametes analyzed Chr 10 maps (N --- 29-69). Thus, there is good evidence that the genetic distance between Myb and Mdm-1/Ifg is ap- Figure 1 shows the updated versions of the "consen- proximately 56 cM. There are few common markers sus map", the "proviral/RI map" and the "SSLP outside this interval, so there is greater uncertainty (simple sequence repeat length polymorphism) map". about map distances in the centrometric and telomeric Only a few significant changes have been made to the regions. consensus map. These are indicated in the legend of Several adjustments have been made in the RI/ Fig. 1. Since there are few common loci between the proviral map to accommodate new information. The proviral/RI and consensus maps, it is not yet possible orientation of Hsd, Gad-lps, DlONds2, and Xrnv-31 to accurately place most RI markers on the consensus has been reversed on the basis of RI strain typing of map. Mdm-1 and other data (Taylor et al. 1992; B.A. Taylor, unpublished data), although the revised order is not firmly established. Likewise, the position of pg rela- *Chair of Committee for Mouse Chromosome 10 tive to DlOMit14 has been reversed. This is based on B.A. Taylor et al.: Mouse Chr 10 S155 Table 1. Locus list for mouse Chr 10. New Symbol Naln~ A M CL Method H. symbol H. location References Acp-2 See Apk Act-2 actin related gene-2 8 D L 52 Adn adipsln D,B S 104 Ahi- I Abelson hdpea'inte,gration site 14 D S, L 52, 88 Amh anti-Mullerian hormone 41.5 D, B L AMIt 19p13.3 54 A# acid phosphatase-kidney(ex Acp-2) 32 B L 121,122 Ass-ps2 ar~ceinate synthetasepseudogene-2 D S 79 at atrichosis 66-72 V L 49 av Ame* waltzer 42 V L 80, 95 Bcr breakpoint cluster rcgim hornolog 34.5 D L BCR 22qi1 52 Bpb See S100b Braf Braf transforminggene 20.5 D, B 52 Bsg b.sigin 39 D,B 101 Cat dominant cataract 72 V 46, 63, 76 Cdl8 See Itgb2 Cdc2a cell division cycle 2 homolog~Chr 10 33.5 D, B S, L CDC2 10q21.1 52 Cis See Cs Cnx43 See Gja-1 Col6a-I proconagen type VI, alpha 1 35.5 D, B S, L, P COL6A1 21q22.3 52, 65, 89, 90 Col6a-2 procollagen type VI, alpha 2 35.5 D,B S,L,P COL6A2 21q22.3 52,65 * CollOa-1 procoUagen type X, alpha 1 20.5 D, B L COL10A1 6r 3 Cs citrate synthase (ex Cis, Cts) B S CS 12pll-qter 27 Cts See C.s DONds22 See D10Nds3 * DlOBirl DNA segraent, Chr 10, Birkenmei~r-1 (5z) 9 * DlOBir2 DNA segrmmt,Chr I0, Birkenmeier-2 (2) 9 * DlOBir3 DNA segment, l~ar 10, Birkenmeier-3 0) 9 * DlOByul DNA ~gmeet, Chr 10, (i .5) 123 Brigham Yeamg University-1 DlOCosl DNA segment, Chr 10, Cmtanfini-1 29 D,B L 52 DIOHI2553E DNA segment, Chr 10, human D12S53E, 69 D S,L D12S53E 12pter-q21 56 ex D12S53Eh (Pmell 7; ?= silver) D l OLedl DNA segment, Cbr 10, I.~ler-1, 56-58 7,48 ex D10l_e,d3 D l OLed3 See D10Ledl * D1OLerl DNA segment, Chr 10, Le Roy-1 3 D L 60 * DlOLer2 DNA segment, Chr 10, Le Roy-2 78 D L 60 * DIOMc2 DNA segment, Chr 10, MeClelland-2 (55) D R 116 DlOMitl DNA segment, Chr 10, MIT-1 (5) D L 30 DlOMit2 DNA segment, Chr 10, M1T-2 (I0) D L,R 30 DlOMit3 DNA segment, Chr 10, MIT-3 (15) D L 30 DlOMit4 DNA segment, Chr 10, MIT-4 (14) D L 30 D lOMit5 DNA segment, Chr 10, M1T-5 (22) D L 30 DlOMit7 DNA segment, Oar 10, Mrr-7 (43) D L 30 DlOMit8 DNA segment, Oar 10, MIT-8 (45) D L 30 D l OMit9 DNA segment, Oar 10, MIT-9 (51) D L 30 DlOMitlO DNA segment, Chr 10, MIT-10 (53) D L,R 30 DlOMitll DNA segment, Chr 10, MIT-I I (53) D L,R 30 DlOMit12 DNA segment, Chr I0, MIT-12 (54) D L 30 DlOMit13 DNA segment, oar I0, MIT-13 (64) D L 30 DlOMit14 DNA segment, oar I0, MlT-14 (72) D L,R 30 DlOMitl5 Sen D1 0Mit20 * DlOMitl6 DNA segment, oar 10, MIT-16 (11) D L 31 * DlOMit17 DNA segment, Oar 10, MIT-17 (11) D L 31 * DlOMit19 DNA segment, Oar 10, MIT-19 (23) D L 31 * DlOMit20 DNA segment, Chr 10, M1T-20 (26) D L 31 (= D10Mitl 5, Sqr3) * DlOMit21 DNA segment, oar 10, M1T-21 (43) D L 31 * DlOMit22 DNA segment, oar 10, MIT-22 (43) D L 31 * DlOMit23 DNA segment, Chr 10, MIT-23 (43) D L 31 * DlOMit24 DNA segment, Chr 10, Mrr-24 (72) D L 31 * DlOMit25 DNA segment, Chr 10, MIT-25 (77) D L 31 * DlOMit28 DNA segment, Chr 10, MIT-2g (3) D L 31 * DlOMit29 DNA segment, oar 10, MIT-29 (23) D L 31 * DlOMit30 DNA segment, oar 10, M1T-30 (23) D L 31 * DlOMit31 DNA segment, oar 10, MIT-31 O3) D L 31 * DlOMit32 DNA segment, Oar 10, MIT-32 O6) D L 31 * DlOMit33 DNA segment, Chr 10, MIT-33 (64) D L 31 * DlOMit34 See D10Mit33 * DlOMit35 DNA segment. Chr 10, MIT-35 (77) D L 31 * D10Mit36 DNA segment, Chr 10, M1T-36 D L 31 * D10Mit38 DNA segment, Chr 10, M1T-38 (22) D L 31 * DlOMit40 DNA segment, Chr 10, MIT-40 (22) D L 31 * DlOMit41 DNA segment, Chr 10, MIT-41 (53) D L 31 * D10Mit42 DNA segment, oar 10, MIT-42 (44) D L 31 * DlOMit43 DNA segment, Cht 10, Mrr-43 (53) D L 31 Continued on next page S156 B.A. Taylor et al.: Mouse Chr 10 Table 1. Continued. New S~rmbol Name AM CL T Method H. symbol H. location References * DlOMit44 DNA segment, Chr 10, MIT-44 (17) D L 31 * DlOMit45 DNA segment, Chr 10, M/T-45 (17) D L 31 * DlOMit46 DNA segment, Chr 10, MIT-46 (67) D L 31 * DlOMit47 DNA segment, Chr 10, M1T-47 (67) D L 31 * DlOMit48 DNA segment, Chr 10, MIT-48 (24) D L 31 DlONdsl DNA segmunt, Chr 10, O) D L,R 26,30 Nuffield Deparunent of Surgery-1 DlONds2 DNA segment, Chr 10, (59) D L,R 26,30 Nuffield Department of Surgery-2 DtONdr3 DNA segnsmt, Chr 10, (22) D L 26,30 Nuftield Deparmaent of Sursery-3 (ex DONds22) DlOPasl DNA ~Fnent, Chr 10, Pasteur Institute-1 37.5 D L 15 DlOPas2 DNA segment, Chr 10, Pasteur Institute-2 32.5 D L 15 * D10Pas3 DNA ~'.sment, Chr 10, Pasteur Institute-3 32.5 D L 97 DI2S53Eh See DlOH12S53E dl downless 29.5 V, D L, S 28, 41 87, 98, 107,122 Dradl dystrophin-llke 0.5 D, B L DMDL 6:124 15 ay dystrophia museularis.
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