MILLIPLEX® map IMMUNOLOGY FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

HUMAN (mature) (LTA) IL-4 IL-5 IL-6 IL-10 IL-13 / CCL3 MIP-1α / CCL4 MIP-1β Perforin TNFα IL-12 (p70) IL-12 IL-13 / CTLA8 IL-17A IL-21 IL-23 / CXCL11 I-TAC / CCL3 MIP-1α / CCL4 MIP-1β / CCL20 MIP-3α TNFα / IL-25 IL-17E IL-17F IL-21 IL-22 IL-23 IL-27 / IFNλ2 IL-28A IL-31 / NF-HEV IL-33 / CCL20 MIP-3α TNFα TNFβ/Lymphotoxin-α EMDMillipore.com/milliplex | 7 EMDMillipore.com/milliplex (Cat. No. HCD8MAG-15K) (Cat. No. (Cat. No. HCD8MAG15K17PMX) (Cat. No. HCD8MAG15KPX17BK) (Bulk Cat. No. (Cat No. HSTCMAG384-PX21) (Cat No. HSTCMAG384PX21BK) (Bulk Cat. No. HT17MG-14K-PX25) (Cat. No. HT17MAG14PMX25BK) (Bulk Cat. No.

TNFRSF9 Serum/Plasma only samples only Tissue Culture format assay Competitive Available for custom premix Available sample a different Analyte requires dilution from others in panel

sCD137/4-1BB/ / TNFRSF6 sFAS sFasL GM-CSF Granzyme A Granzyme B IFNγ IL-2 / CX3CL1 Fractalkine GM-CSF IFNγ IL-1β IL-2 IL-4 IL-5 IL-6 IL-7 / CXCL8 IL-8 IL-10 GM-CSF IFNγ IL-1β IL-2 IL-4 IL-5 IL-6 IL-9 IL-10 (p70) IL-12 IL-13 IL-15 / CTLA8 IL-17A 21 21 17 17 25 25 Human CD8+ T Cell 384-well Human High High Human 384-well Sensitivity T Cell HSTC384-28K) (Cat.No. Human Th17 HTH17MAG-14K) (Cat. No.

● ★ ^ ◦ ♦ ♦ ♦ ♦ ♦ NEW IL-12 (p70) IL-12 IL-13 / CTLA8 IL-17A IL-21 IL-23 / CXCL11 I-TAC / CCL3 MIP-1α / CCL4 MIP-1β / CCL20 MIP-3α TNFα M-CSF MIG / CXCL9 / CCL20 MIP-3α / CCL19 MIP-3β ▲ / CXCL7 NAP-2 / IFNλ3 IL-28B IL-32α IL-34 IL-35 / IL-1F8 IL-36β / IL-1F7 IL-37 / IL-1F10 IL-38 / CCL18 / PARC MIP-4 MPIF / CCL23 YKL40/CHI3L1 ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ These analytes cannot be plexed withThese analytes cannot be plexed other analytes in this panel in serum/ plasma a protease inhibitor during Requires sample collection sample extraction Requires No standard/QC; autoantibody levels as MFIs reported are (Cat. No. HSTCMAG-28SK) (Cat. No. (Cat. No. HCYP4MAG-64K) (Cat. No. HSTCMAG28SPMX13) (Cat. No. HSTCMAG28PMX13BK) (Bulk Cat. No. (Cat. No. HCY4MG-64K-PX21) (Cat. No. HCP4MG64KPX21BK) (Cat. No. HSTCMAG28SPMX21) (Cat. No. HSTCMAG28PMX21BK) (Bulk Cat. No.

/ CX3CL1 Fractalkine GM-CSF IFNγ IL-1β IL-2 IL-4 IL-5 IL-6 IL-7 ♦ / CXCL8 IL-8 IL-10 IL-18 APRIL / TNFSF13 / Blys BAFF BRAK / CXCL14 CCL28 CXCL16 / CCL16 HCC-4 HMGB1 ● IFNβ / α-Taxilin IL-14 IL-19 IL-24 / CCL14 ▲ HCC-1 IL-11 / IFNλ1 IL-29 / CXCL11 I-TAC / GCP-2 LIX / CXCL6 / XCL1 Lymphotactin ▲  ◗ ■ ** 21 13 13 21 21 21 Human IL-18 Singleplex Human IL-18 HIL18MAG-66K) (Cat. No. Human High Sensitivity T Cell Human Cytokine/Chemokine IV Panel Human Cytokine/ChemokineHuman III Panel HCYP3MAG-63K) (Cat.No. map kits ♦ ® ▲ ▲ ♦ ♦ ♦ ▲ ♦ ♦ ♦ ♦ ♦ ♦ (mature) (LTA) IL-28A/IFNλ2 IL-33/NF-HEV LIF MCP-2/CCL8 MCP-4/CCL13 MIP-1δ/MIP-5/CCL15 SCF SDF-1/CXCL12 TARC/CCL17 TPO TRAIL/TNFSF10 TSLP IL-9 IL-10 (p40) IL-12 (p70) IL-12 IL-13 IL-15 / CTLA8 ♦ IL-17A ♦ / CXCL10 IP-10 ♦ / CCL2 MCP-1 / CCL7 MCP-3 MDC / CCL22 ♦ / CCL3 MIP-1α ♦ / CCL4 MIP-1β PDGF-AA BB / PDGF-AB RANTES / CCL5 ♦ TGFα TNFα TNFβ / Lymphotoxin-α VEGF-A

♦ ♦ Analytes which cannot be plexed together: and total – Active and total – Free listed in Cat. No. Available Premix panel only Premix ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦

♦ ▼ Legend key for MILLIPLEX key Legend † Bulk indicates Space Saver Packaging Bulk indicates Space Saver (Cat. No. HCYP2MAG-62K) (Cat. No. (Cat. No. HCYTOMAG-60K) (Cat.No. (Bulk Cat. No. HCP2MAG62KPX23BK) (Bulk Cat. No. (Cat. No. HCP2MAG-62K-PX23) (Cat. No. (Cat. No. HCYTMAG-60K-PX29) (Cat. No. HCYTMAG60PMX29BK) (Bulk Cat. No.

(Bulk Cat. No. HCYTMAG60PMX41BK) (Bulk Cat. No. HCYTMAG60PMX30BK) (Bulk Cat. No. HCYTMAG-60K-PX38) (Cat. No. HCYTMAG60PMX38BK) (Bulk Cat. No. HCYTMAG-60K-PX41) (Cat. No. HCYTMAG-60K-PX30) (Cat. No. MPIF-2 Exodus-2

BCA-1/CXCL13 CTACK/CCL27 ENA-78/CXCL5 Eotaxin-2/CCL24/ Eotaxin-3/CCL26 I-309/CCL1 IL-16 IL-20 IL-21 IL-23 6Ckine/CCL21/ sCD40L EGF Eotaxin / CCL11 ♦ / FGF-basic FGF-2 Flt3 Ligand / CX3CL1 Fractalkine G-CSF GM-CSF GRO IFNα2 IFNγ IL-1α IL-1β IL-1Ra IL-2 IL-3 IL-4 IL-5 IL-6 IL-7 ♦ / CXCL8 IL-8 23 23 41 30 38 38 41 29 29 30 Human Cytokine/Chemokine II Panel Immunology Human Cytokine/Chemokine I Panel HUMAN FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® map IMMUNOLOGY / IMMUNE RESPONSE / METABOLISM / ENDOCRINOLOGY

HUMAN (Cat. No.(Cat. HCMP1MAG-19K) PanelHuman Complement 1 No.(Cat. HSCRMAG-32K) Receptor Human SolubleCytokine (Bulk Cat. No.(Bulk Cat. TGFBMAG-64K-01BK) No.(Cat. TGFBMAG-64K-01) Singleplex Multi-Species TGFβ – No.(Cat. HTMP2MAG-54K) culture(Cell samples) Human TIMPPanel 2 No.(Cat. HTMP1MAG-54K) (Serum/Plasma samples) Human TIMPPanel 1 No.(Cat. HMMP2MAG-55K) Human MMPPanel 2 No.(Cat. HMMP1MAG-55K) Human MMPPanel 1 No.(Cat. HCMP2MAG-19K) PanelHuman Complement 2 8 |EMDMillipore.com/milliplex 14 14 TGFβ1 TIMP-2 TIMP-1 TIMP-1 MMP-7 MMP-2 MMP-1 MMP-12 MMP-3 C4 C3b /iC3b C3 C1q C5 C4b C2 Adipsin/Factor D sIL-4R sIL-2Rα sIL-1RII sIL-1RI sGP130 sEGFR/sHER1/ErbB1 sCD30

(Bulk Cat. No.(Bulk Cat. HSCRMAG32PMX14BK) No.(Cat. HSCRMAG32KPX14) TIMP-4 TIMP-3 TIMP-2 MMP-10 MMP-9 MMP-13 Factor P/Properdin Factor H Factor B Mannose-binding Factor I C9 C5a sVEGFR3 /sFlt-4 sVEGFR2 /sKDRsFlk-1 sVEGFR1 /sFlt-1 sTNF RII sTNF RI sRAGE sIL-6R Lectin (MBL) Isotyping Isotyping Human Immunoglobulin (Cat. No.(Cat. HAIAB-10K) (Cat. No.(Cat. SKINMAG-50K) only) (Skin extracts Human Skin No.(Cat. HSP3MAG-63K) Human SepsisPanel 3 No.(Cat. HSP2MAG-63K) Human SepsisPanel 2 No.(Cat. HSP1MAG-63K) Human SepsisPanel 1 Autoantibody** Human Autoimmune Immune Response No.(Cat. TGFBMAG-64K-03) Multi-Species TGFβ –3Plex Proteinase 3 PM/Sci 100 PL-12 (Alanyl-tRNA PCNA (Proliferating Myeloperoxidase Mi-2 Ku Jo-1 CENP-B (Centromere CENP-A (Centromere C1q β2-Glycoprotein NON-CONFIGURABLE KIT IgG2 IgG1 IgA Human Serum Fibronectin ^ Cortisol NGAL/Lipocalin-2 Neutrophil Elastase-2 Lactotransferrin (LTF) IL-8 /CXCL8 IL-1α HSP70 Granzyme B sICAM-1 sFasL sFAS /TNFRSF6 TGFβ2 TGFβ1 Synthetase) Antigen A) Cell Nuclear (MPO) Protein B) Protein A)

Albumin (HSA) (ELA2) (Cat. No.(Cat. HGAMMAG-301K) SB/La (Sjögren’s SSA/Ro60 SSA/Ro52 (Sjögren’s Sm Scl-70 RNP/Smith (RNP/ RNP Ribosomal P IgM IgG4 IgG3 Keratin-6 Keratin-1,10 Involucrin Thrombospondin-1 Resistin MMP-8 MIP-1β /CCL4 MIP-1α /CCL3 sVCAM-1 PAI-1 (total) MIF TGFβ3 antigen B/La) Syndrome-related kDa) antigen A/Ro60 Syndrome-related (Sjögren’s kDa) antigen A/Ro52 Syndrome-related Sm) (Ribonucleoprotein) (TSP-1) ▼ Human Adipocyte Human Adipocyte No.(Cat. HADK2MAG-61K) (Serum/Plasma samples) Human AdipokinePanel 2 No.(Cat. HADK1MAG-61K) (Serum/Plasma samples) Human AdipokinePanel 1 Endocrinology Metabolism/ No.(Cat. HGAMMAG-303E) Human IgE –Singleplex (Cat. No.(Cat. HMYOMAG-56K) Human Myokine No.(Cat. HMHEMAG-34K) Hormone Human Metabolic Human Diabetes No.(Cat. HADCYMAG-61K) culture(Cell samples) 5 5 NON-CONFIGURABLE KIT Insulin IL-8/CXCL8 IL-6 IL-1β HGF NGAL/Lipocalin-2 Adipsin/Factor D Adiponectin IgE IL-6 FSTL1 Fractalkine/CX3CL1 FGF-21 FABP3 (EPO) Erythropoietin BDNF Apelin Glucagon †◗ (total) GLP-1 (active) †◗ GLP-1 GIP (total) Ghrelin (active) C-Peptide †◗ (total) Amylin (active) †◗ Amylin Glucagon GLP-1 (active) C-Peptide Leptin IL-8/CXCL8 IL-6 IL-1β HGF Adiponectin HDIAB-34K-PMX5) (Cat.No. (Bulk Cat. No.(Bulk Cat. HDIAB34KPMX5BK) ◗ ◗ ◗ ◗ TNFα NGF MCP-1/CCL2 Leptin Resistin PAI-1 (total) Osteonectin/SPARC Osteocrin (OSTN)/ (OSM) Oncostatin-M Myostatin/GDF8 LIF Irisin IL-15 TNFα PYY (total) Pancreatic MCP-1/CCL2 Leptin Insulin IL-6 TNFα Resistin PAI-1 (total) NGF MCP-1/CCL2 Leptin Insulin ▼ Musclin Polypeptide (PP) MILLIPLEX® map METABOLISM / ENDOCRINOLOGY / CVD / BONE / CANCER FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

HUMAN NEW Osteocalcin (OC) Osteopontin (OPN) (OPG) Osteoprotegerin PTH Sclerostin (SOST) TNFα GITRL HVEM ICOS LAG-3 PD-1 PD-L1 TIM-3 TLR-2 IGF2BP2/IMP2 IGF2BP3/IMP3 Mucin-1 (MUC1) P16-INK4a p53 SOX2 Survivin/BIRC5 IL-8/CXCL8 Leptin MIF Osteopontin (OPN) Prolactin PSA (free)† PSA (total)† SCF TGFα TNFα TRAIL/TNFSF10 VEGF-A EMDMillipore.com/milliplex | 9 EMDMillipore.com/milliplex Serum/Plasma only samples only Tissue Culture format assay Competitive Available for custom premix Available sample a different Analyte requires dilution from others in panel ACTH DKK1 FGF-23 IL-1β IL-6 Insulin Leptin RANKL BTLA CD27 CD28 CD40 CD80/B7-1 CD86/B7-2 CTLA-4/CD152 GITR CCNB1/Cyclin B1 CCNB1/Cyclin CTAG1B/NY-ESO-1 ENO1 Galectin-1 (GAL1) Galectin-3 (GAL3) HER2/ErbB2 HIF-1α HSP60 (AFP) α-Fetoprotein CA125 CA15-3 CA19-9 CEA CYFRA21-1 sFAS/TNFRSF6 sFasL FGF-2/FGF-basic HCGβ HE4 HGF IL-6 Human Cancer Autoantibody** Bone Human Bone HBNMAG-51K) (Cat.No. Singleplex Human RANKL – HRNKLMAG-51K-01) (Cat. No. Cancer Human Immuno-Oncology Checkpoint Protein HCKPMAG-11K) (Cat. No. (Cat. No. HCABMAG-13K) HCABMAG-13K) (Cat. No. Human Circulating Cancer 1 Panel Biomarker HCCBP1MAG-58K) (Cat. No.

● ★ ^ ◦ (LEPR)/OB-R (PF4)/CXCL4 (SAP) (vWF) LRG1 MCAM/MUC18 ucMGP Apo CII Apo CIII Apo E Pentraxin-3 (PTX3) Pentraxin-3 Thrombomodulin (TF) Tissue Factor T (TnT) Troponin Leptin Receptor MR-ProADM Notch1 PLA2G7 PTGDS sST2/IL1RL1 Syndecan 4 (SYND4) Myoglobin NGAL/Lipocalin-2 sP-Selectin A Serum Amyloid sVCAM-1 Haptoglobin sL-Selectin 4 Platelet Factor P Serum Amyloid Willebrand Factor von These analytes cannot be plexed withThese analytes cannot be plexed other analytes in this panel in serum/ plasma a protease inhibitor during Requires sample collection sample extraction Requires No standard/QC; autoantibody levels as MFIs reported are (CHGA/CGA) (AGP) (MPO) Apo AI Apo AII Apo B sCD14 DPP4 Endostatin pGRN sCD31/sPECAM-1 dPAPP-A sE-Selectin (FST) Follistatin ADAM15 Cadherin 13 (CDH13) sCD163 Chromogranin-A HSP60 IGF1R LDLR α-1-Acid Glycoprotein Glycoprotein α-1-Acid α-2-Macroglobulin D Adipsin/Factor CRP A Fetuin Fibrinogen ADAMTS13 D-dimer GDF-15 sICAM-1 Myeloperoxidase ▲  ◗ ■ ** Human CVD Panel 6 Human CVD Panel HCVD6MAG-67K) (Cat. No. Human Apolipoprotein APOMAG-62K) (Cat. No. Human CVD Panel 4 Human CVD Panel HCVD4MAG-67K) (Cat. No. 5 Human CVD Panel HCVD5MAG-67K) (Cat. No. Human CVD Panel 3 Human CVD Panel (Acute Phase) HCVD3MAG-67K) (Cat. No. Human CVD Panel 2 CVDHuman Panel HCVD2MAG-67K) (Cat.No. map kits ◗ ® ^

■ NEW ★ Factor (PLGF) Factor LIX/CXCL6/GCP-2 NT proBNP Oncostatin-M (OSM) Placental Growth I (TnI) Troponin FSH GH LH TSH Testosterone T3 T4 IGF-2 IGFBP5 IGFBP6 IGFBP7 FGF-19 FGF-21 FGF-23 HGF IL-18 Jag1 Leptin Wnt-3a IL-10 ■

Analytes which cannot be plexed together: and total – Active and total – Free listed in Cat. No. Available Premix panel only Premix

♦ ▼ Legend key for MILLIPLEX key Legend † Bulk indicates Space Saver Packaging Bulk indicates Space Saver Protein (AgRP) BNP CK-MB CXCL16 Endocan-1 (ESM-1) FABP3 FABP4 LIGHT Cortisol Estradiol Progesterone CNTF ACTH Agouti-Related IGF-1 IGFBP1 IGFBP2 IGFBP3 IGFBP4 α-Fetoprotein (AFP) α-Fetoprotein ANGPTL3 ANGPTL4 ANGPTL6 FABP1 CTACK/CCL27 FGF-21 GDF-11 GDF-15 GnRH IL-6 Human CVD Panel 1 Human CVD Panel HCVD1MAG-67K) (Cat. No. Cardiovascular (Cat. No. MSHMAG-21K) (Cat. No. Multi-Species Hormone Multi-Species (Cat. No. HPTP1MAG-66K) (Cat. No. Human Pituitary 1 Panel Human IGF HIGFMAG-52K) (Cat. No. Human IGF Binding Protein Human IGF Binding HIGFBMAG-53K) (Cat. No. (Cat. No. HLPPMAG-57K) (Cat. No. Human Liver Protein Human Liver Human Aging Panel 1 Panel Aging Human HAGE1MAG-20K) (Cat.No. FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® map CANCER / NEUROSCIENCE / TOXICITY

HUMAN 10 |EMDMillipore.com/milliplex (Cat. No.(Cat. HCCBP3MAG-58K) Biomarker Panel 3 Human CirculatingCancer No.(Cat. HCCBP2MAG-58K) Biomarker Panel 2 Human CirculatingCancer (Cat. No.(Cat. HANG2MAG-12K) Human AngiogenesisPanel 2 No.(Cat. HAGP1MAG-12K) Factor Panel 1 Human Angiogenesis/Growth No.(Cat. HCMBMAG-22K) Biomarker Panel 1 Human Cancer/Metastasis No.(Cat. HCCB4MAG-58K) Biomarker Panel 4 Human CirculatingCancer sHGFR/sc-Met sHER3/sEGFR3/ sHER2/sEGFR2/ sEGFR/sHER1/sErbB1 sE-Selectin sc-Kit/sStem Cell sCD31/sPECAM-1 sAXL Angiostatin/Kringle G-CSF Follistatin (FST) FGF-2/FGF-basic FGF-1/FGF-acidic Endothelin-1 Endoglin EGF BMP-9 Angiopoietin-2 Osteonectin/SPARC Neuron-specific GDF-15 DKK1 Hepsin EpCAM CD44 AnhydraseCarbonic ALDH1A1 IGFBP3 Galectin-3 Fibroblast Activation Ferritin D Cathepsin Complement Factor Antithrombin III sErbB3 sErbB2 (SCFR) Factor Receptor Enolase (NSE) 9 (CA9) Protein (FAP) H (CFH) sVEGFR3/sFlt-4 sVEGFR2/sKDR/sFlk-1 sVEGFR1/sFlt-1 suPAR sTIE-2 Thrombospondin-2 Tenascin-C (TN-C) PDGF-AB/BB Osteopontin (OPN) sNeuropilin-1 (sNRP-1) sIL-6Rα VEGF-D VEGF-C VEGF-A Growth Placental Leptin IL-8/CXCL8 HGF HB-EGF YKL40/CHI3L1 TWEAK TRAP5 Periostin Osteoprotegerin Transglutaminase 2 NCAML1/L1CAM/ Midkine Mesothelin Kallikrein-6 Sex HormoneBinding Myeloperoxidase Melanoma Inhibitory DBinding Vitamin Matrix Extracellular (TSP-2) Factor (PLGF) (OPG) (TGM2) CD171 Globulin (SHBG) (MPO) (MIA) Activity Protein Protein 1(ECM1) (Cat. No.(Cat. HND3MAG-39K) PanelDisorders 3 Human Neurological No.(Cat. HNDG4MAG-36K) Disease Panel 1 Human Neurodegenerative No.(Cat. HNS2MAG-95K) Human NeurosciencePanel 2 No.(Cat. HNS1MAG-95K) samples) (CSF Human NeurosciencePanel 1 No.(Cat. HNABTMAG-68K) samples) (CSF Human Amyloid andTau Beta Neuroscience (CSF samples) (CSF Disease Panel 4 Human Neurodegenerative No.(Cat. HNDG3MAG-36K) Disease Panel 3 Human Neurodegenerative No.(Cat. HNDG2MAG-36K) Disease Panel 2 Human Neurodegenerative No.(Cat. HNDG1MAG-36K) Kallikrein-6 Fetuin A Contactin-1 Angiotensinogen GDNF Amyloid 1-42 beta Amyloid 1-40 beta Ferritin FABP3 ApoE4 Angiogenin (ANG) Neuron-specific Acidic Glial Fibrillary α-Synuclein Amyloid 1-42 beta Amyloid 1-40 beta sNCAM Myeloperoxidase sICAM-1 D Cathepsin BDNF CRP C4 α-1-Antitrypsin (A1AT) Apo E Apo CIII Apo AI α-2-Macroglobulin (AGT) Enolase (NSE) Protein (GFAP) (MPO) ◦ ◦ ◦ Soluble Superoxide Soluble Superoxide Soluble Superoxide Osteopontin (OPN) S100B sRAGE TREM2 PRNP (PrionProtein) Neurogranin (NRGN) Transglutaminase 2 PARK7/DJ1 PARK5/UCHL1 Tau (total) pTau (Thr181) sVCAM-1 RANTES/CCL5 PDGF-AB/BB PDGF-AA PAI-1 (total) Serum Amyloid P PEDF MIP-4/PARC/CCL18 Complement Factor Complement Factor Dismutase 2 (sSOD2) Dismutase 1(sSOD1) Dismutase (TGM2) (SAP) H (CFH) C3

(Cat. No.(Cat. HKI2MAG-99K) (Urine samples) PanelHuman Kidney Injury 2 No.(Cat. HKI1MAG-99K) (Urine samples) PanelHuman Kidney Injury 1 Toxicity No.(Cat. HNCSMAG-35K) Human CircadianStress No.(Cat. HNPMAG-35K) Human Neuropeptide (Cat. No.(Cat. HLINJMAG-75K) Human Liver Injury No.(Cat. HKI6MAG-99K) (Serum/Plasma samples) PanelHuman Kidney Injury 6 No.(Cat. HKI5MAG-99K) (Serum/Plasma samples) PanelHuman Kidney Injury 5 No.(Cat. HKI4MAG-99K) (Serum/Plasma samples) PanelHuman Kidney Injury 4 No.(Cat. HKI3MAG-99K) (Urine samples) PanelHuman Kidney Injury 3 IP-10/CXCL10 GSTα FABP1 Collagen IV Calbindin Cortisol Neurotensin β-Endorphin α-MSH GSTα ARG1 5'NT/CD73 Clusterin β-2-Microglobulin NGAL/Lipocalin-2 Collagen IV α-1-Microglobulin KIM-1 IP-10/CXCL10 FABP1 EGF RBP4 β-2-Microglobulin Cystatin C Clusterin Albumin α-1-Microglobulin TIMP-1 TFF-3 Renin Osteoactivin KIM-1 Melatonin P Substance Oxytocin SDH MDH1 RBP4 Cystatin C Uromodulin TIMP-1 Osteoactivin Renin PTH Osteopontin (OPN) Uromodulin Osteopontin (OPN) NGAL/Lipocalin-2 EGF ■

^ ■

^ MILLIPLEX® map IMMUNOLOGY / METABOLISM / ENDOCRINOLOGY FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

NHP / MOUSE (mature) (LTA) IL-17E/IL-25 IL-17F IL-21 IL-22 IL-23 IL-27 IL-28B/IFNλ3 IL-31 IL-33/NF-HEV MIP-3α/CCL20 TNFα TNFβ/Lymphotoxin-α IL-4 IL-5 IL-6 IL-10 IL-13 MIP-1β/CCL4 RANTES/CCL5 TNFα IL-17A/F IL-20 MDC/CCL22 MCP-5/CCL12 MIP-3α/CCL20 MIP-3β/CCL19 TARC/CCL17 TIMP-1 IL-10 (p70) IL-12 IL-13 IL17A/CTLA8 KC/GROα/CXCL1 LIX MCP-1/CCL2 MIP-2/CXCL2 TNFα EMDMillipore.com/milliplex | 11 EMDMillipore.com/milliplex (Cat. No. MECY2MAG-73K) (Cat.No. (Cat. No. MTH17MAG-47K) (Cat. No. MCD8MAG-48K) (Cat. No. (Cat. No. MT17MAG47K-PX25) (Cat. No. MT17MAG47PMX25BK) (Bulk Cat. No. MCD8MAG48K-PX15) (Cat. No. MCD8MAG48KPX15BK) (Bulk Cat. No. (Cat. No. MECY2MAG-73KPX) (Cat.No. MECY2MAG73KPXBK) (Bulk Cat. No. MHSTCMAG-70KPMX) (Cat. No. MHSTCMAG-70KPXBK) (Bulk Cat. No.

TNFRSF9 CCL21/6Ckine Serum/Plasma only samples only Tissue Culture format assay Competitive Available for custom premix Available sample a different Analyte requires dilution from others in panel

sCD40L GM-CSF IFNγ IL-1β IL-2 IL-4 IL-5 IL-6 IL-10 (p70) IL-12 IL-13 IL-15 IL-17A/CTLA8 sCD137/4-1BB/ sFas/TNFRSF6 sFasL GM-CSF Granzyme B IFNγ IL-2 Erythropoietin (EPO) Exodus-2/ Fractalkine/CX3CL1 IFNβ1 IFNγ IL-11 IL-16 GM-CSF IFNγ IL-1α IL-1β IL-2 IL-4 IL-5 IL-6 IL-7 15 15 25 25 15 15 18 18 Mouse Th17 Mouse CD8+ T Cell Mouse Cytokine/Mouse 2 Panel Chemokine Mouse High Sensitivity T Cell MHSTCMAG-70K) (Cat. No.

● ★ ^ ◦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ Polypeptide (PP) Polypeptide IL-13 IL-15 IL-17A/CTLA8 IP-10/CXCL10 KC/GROα/CXCL1 LIF LIX MCP-1/CCL2 M-CSF MIG/CXCL9 MIP-1α/CCL3 MIP-1β/CCL4 MIP-2/CXCL2 RANTES/CCL5 TNFα VEGF-A Insulin Leptin MCP-1/CCL2 Pancreatic (total)PYY Testosterone T3 T4 FSH GH LH TSH ◗ ◗ ◗ ♦ ♦ ◗ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ These analytes cannot be plexed withThese analytes cannot be plexed other analytes in this panel in serum/ plasma a protease inhibitor during Requires sample collection sample extraction Requires No standard/QC; autoantibody levels as MFIs reported are (Cat. No. MCYTOMAG-70K) (Cat. No. MCYTOMAG-70K-PMX) (Cat. No. MCYTMAG70PMX25BK) (Bulk Cat. No. MCYTMAG-70K-PX32) (Cat. No. MCYTMAG70PMX32BK) (Bulk Cat. No. Protein (AgRP)

GM-CSF IFNγ IL-1α IL-1β IL-2 IL-3 IL-4 IL-5 IL-6 IL-7 IL-9 IL-10 (p40) IL-12 (p70) IL-12 Eotaxin/CCL11 G-CSF GIP (total) (active) GLP-1 Glucagon IL-6 Cortisol Estradiol Progesterone (active) Amylin C-Peptide (active) Ghrelin ACTH Agouti-Related CNTF ▲  ◗ ■ ** 25 25 32 32 Immunology Mouse Cytokine/Chemokine 1 Panel Multi-Species Hormone ■ ^ Multi-Species MSHMAG-21K) (Cat. No. MOUSE (Cat. No. NHPMHMAG-45K) (Cat.No. PituitaryNon-Human Primate 1 Panel NHPPT1MG-46K) (Cat. No. Metabolism/ Endocrinology Primate Non-Human Metabolic Hormone map kits ▼ ® A) (mature) (LT TGFβ3 IL-17E/IL-25 IL-21 IL-22 IL-23 IL-28A/IFNλ2 IL-31 IL-33/NF-HEV IP-10/CXCL10 MIP-3α/CCL20 Perforin RANTES/CCL5 ▲ TNFβ/Lymphotoxin-α IL-12/23 (p40) IL-12/23 IL-13 IL-15 IL-17A/CTLA8 IL-18 MCP-1/CCL2 MIP-1α/CCL3 MIP-1β/CCL4 TGFα TNFα VEGF-A

Analytes which cannot be plexed together: and total – Active and total – Free listed in Cat. No. Available Premix panel only Premix β1

♦ ▼ Legend key for MILLIPLEX key Legend † Bulk indicates Space Saver Packaging Bulk indicates Space Saver (Cat. No. PRCYT2MAG40K) (Cat. No. (Cat. No. PRCYTOMAG-40K) (Cat.No. (Bulk Cat. No. PRCY2MG40PMX24BK) (Bulk Cat. No. PRCYTMAG40K-PX25) (Cat. No. PRCY2MG40PMX25BK) (Bulk Cat. No. (Cat. No. PRCYTMAG40K-PX24) (Cat. No. (Cat. No. PCYTMG-40K-PX23) (Cat.No. PRCYMAG40PMX23BK) (Bulk Cat. No.

TNFRSF9

TGF TGFβ2 TGFβ1 Eotaxin/CCL11 sFasL FGF-2/FGF-basic Fractalkine/CX3CL1 Granzyme A Granzyme B IL-1α IL-2 IL-4 IL-6 IL-16 IL-17A/CTLA8 sCD137/4-1BB/ sCD40L G-CSF GM-CSF IFNγ IL-1β IL-1Ra IL-2 IL-4 IL-5 IL-6 IL-8/CXCL8 IL-10 NON-CONFIGURABLE KIT 24 25 25 24 23 23 Multi-Species TGFβ – 3 Plex TGFβ Multi-Species TGFBMAG-64K-03) (Cat. No. (Cat. No. TGFBMAG-64K-01) (Cat. No. TGFBMAG-64K-01BK) (Bulk Cat. No. Multi-Species TGFβ – TGFβ Multi-Species Singleplex Non-Human Primate Cytokine/Chemokine 2 Panel Non-Human Primate Non-Human Cytokine/Chemokine 1 Panel PRIMATE Immunology FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® map IMMUNOLOGY / IMMUNE RESPONSE / METABOLISM / ENDOCRINOLOGY / CVD / BONE / CANCER

MOUSE 12 |EMDMillipore.com/milliplex (Cat. No.(Cat. MMMP1MAG-79K) (Serum/Plasma samples) Mouse MMPPanel 1 Receptor Mouse SolubleCytokine (Cat. No.(Cat. MGAMMAG-300E) Mouse IgE –Singleplex Isotyping Mouse Immunoglobulin Immune Response No.(Cat. TGFBMAG-64K-03) Multi-Species TGFβ –3Plex No.(Bulk Cat. TGFBMAG-64K-01BK) No.(Cat. TGFBMAG-64K-01) Singleplex Multi-Species TGFβ – No.(Cat. MMMP3MAG-79K) culture(Cell samples) Mouse MMPPanel 3 No.(Cat. MMMP2MAG-79K) (Serum/Plasma samples) Mouse MMPPanel 2 NON-CONFIGURABLE KIT IgE IgG2a IgG1 IgA TGFβ2 TGFβ1 TGFβ1 MMP-8 MMP-3 MMP-2 proMMP-9 MMP-3 MMP-2 sIL-6R sIL-4R sIL-2Rα sIL-1RII sIL-1RI sGP130 sCD30

(Cat. No.(Cat. MGAMMAG-300K) No.(Cat. MSCRMAG-42K) IgM IgG3 IgG2b TGFβ3 MMP-12 proMMP-9 MMP-12 MMP-8 sVEGFR3/sFlt-4 sVEGFR2/sKDR/sFlk-1 sVEGFR1/sFlt-1 sTNF RII sTNF RI sRAGE ▼ (Cat. No.(Cat. MADPNMAG-70K-01) (Serum/Plasma samples) Singleplex Mouse Adiponectin– No.(Cat. MADCYMAG-72K) culture(Cell samples) Mouse Adipocyte No.(Cat. MADKMAG-71K) (Serum/Plasma samples) Mouse Adipokine Endocrinology Metabolism/ (Cat. No.(Cat. MPTMAG-49K) Mouse Pituitary No.(Cat. MMYOMAG-74K) Mouse Myokine No.(Cat. MMHMAG-44K) Hormone Mouse Metabolic Adiponectin MCP-1/CCL2 Leptin IL-6 Adiponectin MCP-1/CCL2 Leptin Insulin IL-6 GH FSH BDNF ACTH IL-15 IL-6 Follistatin-like Fractalkine/CX3CL1 FGF-21 (EPO)★ Erythropoietin BDNF Insulin IL-6 Glucagon GLP-1 (active) GIP (total) Ghrelin (active) C-Peptide 2 Amylin (active) Protein 1(FSTL1) ◗ ◗ ◗ ◗ TNFα Resistin PAI-1 (total) TNFα Resistin PAI-1 (total) TSH Prolactin LH Osteonectin/SPARC Osteocrin (OSTN)/ (OSM) Oncostatin-M Myostatin/GDF8 LIF Irisin TNFα Resistin PYY (total) Pancreatic MCP-1/CCL2 Leptin Musclin Polypeptide (PP) Mouse AcutePhasePanel 2 No.(Cat. MCVD2MAG-77K) PanelMouse CVD 2 No.(Cat. MCVD1MAG-77K) PanelMouse CVD 1 Cardiovascular No.(Cat. MSHMAG-21K) (Cat. No.(Cat. MAGPMAG-24K) Factor Panel 1 Angiogenesis /Growth Mouse Cancer No.(Cat. MBNMAG-41K) Mouse Bone Bone No.(Cat. MAP2MAG-76K) Multi-Species Hormone■ ^ LIGHT Follistatin (FST) Endocan-1 (ESM-1) CXCL16 sCD40L ProMMP-9 sICAM-1 sE-Selectin sCD31/sPECAM-1 Progesterone Estradiol Cortisol IL-1β HGF G-CSF Follistatin (FST) FGF-2/FGF-basic sFasL Endothelin-1 Endoglin EGF ▲ sCD31/sPECAM-1 ▲ Betacellulin Angiopoietin-2 ▲ Amphiregulin sALK-1 Insulin IL-6 FGF-23 DKK1 ACTH α-2-Macroglobulin α-1-Acid Glycoprotein Adipsin/Factor D (AGP) Troponin T(TnT) Troponin I(TnI) PLGF-2 M(OSM) Oncostatin Thrombomodulin sP-Selectin PAI-1 (total) T4 T3 Testosterone VEGF-D VEGF-C VEGF-A TNFα SDF-1/CXCL12 Prolactin Growth Placental MIP-1α/CCL3 MCP-1/CCL2 Leptin KC/CXCL1 IL-17A/CTLA8 IL-6 TNFα Sclerostin (SOST) Osteoprotegerin Leptin Serum Amyloid P Haptoglobin CRP Factor (PLGF-2) (OPG) (SAP) MILLIPLEX® map NEUROSCIENCE / TOXICITY / IMMUNOLOGY / METABOLISM / ENDOCRINOLOGY / CVD FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

MOUSE / RAT ■ 1 (FSTL1) (MYL3) (vWF) LH Prolactin TSH Melatonin^ FABP3 Protein Follistatin-like Light Chain 3 Myosin TIMP-1 IL-6 / MCP-1 CCL2 (total) PAI-1 TIMP-1 TNFα VEGF sICAM-1 Willebrand Factor von Testosterone T3 T4 TSH EMDMillipore.com/milliplex | 13 EMDMillipore.com/milliplex (cTnI) (cTnT) Muscle (CKM) Growth Factor (CTGF) 1 / CXCL1 Serum/Plasma only samples only Tissue Culture format assay Competitive Available for custom premix Available sample a different Analyte requires dilution from others in panel ACTH BDNF FSH GH ACTH Corticosterone^ Cardiac Troponin I Cardiac Troponin T Cardiac Troponin Kinase Creatine Caveolin-1 Tissue Connective / CINC- / KC GROα Adiponectin sE-Selectin Cortisol Estradiol Progesterone T3^ T4^ Rat Pituitary RPTMAG-86K) (Cat.No. Hormone Rat Stress RSHMAG-69K) (Cat. No. ■ ^ Hormone Multi-Species Cardiovascular Rat Cardiac 1 Injury Panel RCI1MAG-87K) (Cat. No. Injury 1 Panel Rat Vascular (Serum/Plasma samples) RV1MAG-26K) (Cat. No. Injury 2 Panel Rat Vascular (Serum/Plasma samples) RV2MAG-26K) (Cat. No. (Cat. No. MSHMAG-21K) (Cat. No. Rat Thyroid RTHYMAG-30K) (Cat. No.

● ★ ^ ◦ ▼ Polypeptide (PP) Polypeptide Musclin Insulin Leptin MCP-1/CCL2 Pancreatic (total)PYY TNFα / CCL2 MCP-1 (total) PAI-1 TNFα MCP-1/CCL2 (total) PAI-1 TNFα IL-6 IL-15 Irisin LIF Osteocrin (OSTN)/ Osteonectin/SPARC TGFβ3 ◗ ◗ ◗ ◗ These analytes cannot be plexed withThese analytes cannot be plexed other analytes in this panel in serum/ plasma a protease inhibitor during Requires sample collection sample extraction Requires No standard/QC; autoantibody levels as MFIs reported are 1 (FSTL1) GIP (total) (active) GLP-1 Glucagon IL-6 (active) Amylin 2 C-Peptide (active) Ghrelin BDNF Erythropoietin (EPO) FGF-21 Fractalkine/CX3CL1 Protein Follistatin-like Myostatin/GDF8 IL-1β IL-6 Insulin Leptin Adiponectin IL-1β IL-6 Leptin TGFβ1 TGFβ1 TGFβ2 NON-CONFIGURABLE KIT ▲  ◗ ■ ** Rat Metabolic Hormone RMHMAG-84K) (Cat. No. Rat Myokine RMYOMAG-88K) (Cat. No. (Cat. No. RADPKMAG-80K) (Cat. No. Rat Adipocyte (Cell samples) culture RADPCMAG-82K) (Cat. No. – 3 Plex TGFβ Multi-Species TGFBMAG-64K-03) (Cat. No. Metabolism/ Endocrinology Rat Adipokine (Serum/Plasma samples) Multi-Species TGFβ – TGFβ Multi-Species Singleplex TGFBMAG-64K-01) (Cat.No. TGFBMAG-64K-01BK) (Bulk Cat. No. map kits ® ■ ^ IL-10 (p70) IL-12 IL-13 IL-17A/CTLA8 IL-18 IP-10/CXCL10 Leptin LIX MCP-1/CCL2 MIP-1α/CCL3 MIP-2/CXCL2 RANTES/CCL5 TNFα VEGF Renin TIMP-1 VEGF-A NGAL/Lipocalin-2 Osteopontin (OPN) Amyloid beta 1-42 Amyloid Oxytocin Substance P

Analytes which cannot be plexed together: and total – Active and total – Free listed in Cat. No. Available Premix panel only Premix

♦ ▼ Legend key for MILLIPLEX key Legend † Bulk indicates Space Saver Packaging Bulk indicates Space Saver (Cat. No. RECYTMAG-65K) (Cat. No. (Cat. No. RECYMAG65K27PMX) (Cat. No. RECYMAG65PMX27BK) (Bulk Cat. No.

1 / CXCL1

IFNγ IL-1α IL-1β IL-2 IL-4 IL-5 IL-6 EGF Eotaxin / CCL11 / CX3CL1 Fractalkine G-CSF GM-CSF / CINC- / KC GROα Clusterin C Cystatin EGF β-2-Microglobulin IP-10/CXCL10 KIM-1 α-MSH β-Endorphin Neurotensin Amyloid beta 1-40 Amyloid 27 27 Immunology Rat Cytokine/Chemokine RAT Mouse Kidney Injury Panel 2 InjuryMouse Kidney Panel MKI2MAG-94K) (Cat. No. Toxicity 1 InjuryMouse Kidney Panel MKI1MAG-94K) (Cat. No. Mouse Neuropeptide RMNPMAG-83K) (Cat. No. (Cat. No. MABMAG-83K) MABMAG-83K) (Cat.No. Neuroscience Beta Mouse Amyloid FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® map BONE / NEUROSCIENCE / TOXICITY / IMMUNOLOGY / METABOLISM / ENDOCRINOLOGY

RAT / OTHER 14 |EMDMillipore.com/milliplex (Cat. No.(Cat. RBN1MAG-31K) (Serum/Plasma samples) Rat BonePanel 1 Bone No.(Cat. RV3MAG-26K) (Serum/Plasma samples) Rat Vascular Panel Injury 3 (Cat. No.(Cat. RLI1MAG-92K) Rat Liver Injury No.(Cat. RKTX2MAG-37K) (Urine samples) Rat Kidney Toxicity Panel 2 No.(Cat. RKTX1MAG-37K) (Urine samples) Rat Kidney Toxicity Panel 1 Toxicity No.(Cat. RMNPMAG-83K) Rat Neuropeptide Neuroscience GOT1 ARG1 5'NT/CD73 β-2-Microglobulin Albumin^ α-1-Acid Glycoprotein IP-10 /CXCL10 GSTα^ Clusterin Calbindin Neurotensin β-Endorphin α-MSH Insulin FGF-23 DKK1 ACTH α-2-Macroglobulin α-1-Acid Glycoprotein (AGP) (A2M) (AGP) SDH GSTα NGAL /Lipocalin-2 EGF Cystatin C VEGF-A TIMP-1 Osteopontin (OPN) KIM-1 P Substance Oxytocin Sclerostin (SOST) PTH Osteoprotegerin (OPG) Leptin Haptoglobin Fibrinogen ■ ^ ▲ Equine Cytokine/Chemokine Cytokine/Chemokine Canine Immunology OTHER SPECIES (Bulk Cat. No.(Bulk Cat. TGFBMAG-64K-01BK) No.(Cat. TGFBMAG-64K-01) Singleplex Multi-Species TGFβ – Porcine Cytokine/Chemokine Feline Cytokine/Chemokine 23 23 13 13 19 19 13 13 NON-CONFIGURABLE KIT IL-5 IL-4 IL-2 IL-1β IL-1α IFNγ GRO GM-CSF G-CSF Fractalkine/CX3CL1 FGF-2/FGF-basic Eotaxin/CCL11 IL-10 IL-8 /CXCL8 IL-7 IL-6 IL-2 IFNγ GM-CSF TGFβ1 IL-4 IL-2 IL-1Ra IL-1β IL-1α IFNγ GM-CSF IL-12 (p40) IL-8 /CXCL8 IL-6 IL-4 IL-2 IL-1β IFNγ GM-CSF Flt3 Ligand sFAS/TNFRSF6

(Cat. No.(Cat. EQCTMG93KPX23BK) No.(Cat. EQCYTMG-93KPX23) No.(Bulk Cat. CCYTMAG90KPX13BK) No.(Cat. CCYTMG-90K-PX13) (Bulk Cat. No.(Bulk Cat. PCYTMAG23PMX13BK) No.(Cat. PCYTMG-23K-13PX) No.(Bulk Cat. FCYTMAG20KPX19BK) No.(Cat. FCYTMAG-20K-PMX) (Cat. No.(Cat. EQCYTMAG-93K) (Cat. No.(Cat. PCYTMAG-23K) (Cat. No.(Cat. CCYTOMAG-90K) TNFα RANTES/CCL5 MCP-1/CCL2 IP-10/CXCL10 IL-18 IL-17A/CTLA8 IL-13 IL-12 (p70) IL-10 IL-8/CXCL8 IL-6 TNFα MCP-1 /CCL2 KC-like IP-10 /CXCL10 IL-18 IL-15 TNFα IL-18 IL-12 IL-10 IL-8/CXCL8 IL-6 TNFα SDF-1 /CXCL12 SCF RANTES /CCL5 PDGF-BB MCP-1 /CCL2 KC/GRO IL-18 IL-13 ▼ (Cat. No.(Cat. CKT2MAG-97K) (Urine samples) 2 Kidney ToxicityCanine Panel No.(Cat. CKT1MAG-97K) (Urine samples) Expanded Panel 1 Kidney ToxicityCanine Toxicity No.(Cat. MSHMAG-21K) Feline Hormone Metabolic No.(Cat. CPTMAG-96K) Pituitary Canine No.(Cat. CGTMAG-98K) GutHormone Canine Endocrinology Metabolism/ No.(Cat. TGFBMAG-64K-03) Multi-Species TGFβ –3Plex Multi-Species Hormone■ ^ No.(Cat. FMHMAG-29K) NON-CONFIGURABLE KIT β-2-Microglobulin Albumin KIM-1 IL-8 /CXCL8 Cystatin C Clusterin Progesterone Estradiol Cortisol FSH BDNF ACTH Glucagon GLP-1 (active) ◗ GIP (total) Ghrelin (active) Amylin ◗ (total) TGFβ2 TGFβ1 Glucagon GLP-1 (active) GIP (total) Ghrelin (active) Amylin (active) ◗ ◗ ◗ ◗ ◗ TFF-3 RBP4 Osteopontin (OPN) NGAL /Lipocalin-2 MCP-1 /CCL2 T4 T3 Testosterone TSH GH PYY (total) Pancreatic Leptin Insulin TGFβ3 PYY (total) Pancreatic Leptin Insulin Polypeptide (PP) Polypeptide (PP) ▼