Skin Eruptions Specific to Pregnancy: an Overview
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Update on Challenging Disorders of Pigmentation in Skin of Color Heather Woolery-Lloyd, M.D
Update on Challenging Disorders of Pigmentation in Skin of Color Heather Woolery-Lloyd, M.D. Director of Ethnic Skin Care Voluntary Assistant Professor Miller/University of Miami School of Medicine Department of Dermatology and Cutaneous Surgery What Determines Skin Color? What Determines Skin Color? No significant difference in the number of melanocytes between the races 2000 epidermal melanocytes/mm2 on head and forearm 1000 epidermal melanocytes/mm2 on the rest of the body differences present at birth Jimbow K, Quevedo WC, Prota G, Fitzpatrick TB (1999) Biology of melanocytes. In I. M. Freedberg, A.Z. Eisen, K. Wolff,K.F. Austen, L.A. Goldsmith, S. I. Katz, T. B. Fitzpatrick (Eds.), Dermatology in General Medicine 5th ed., pp192-220, New York, NY: McGraw Hill Melanosomes in Black and White Skin Black White Szabo G, Gerald AB, Pathak MA, Fitzpatrick TB. Nature1969;222:1081-1082 Jimbow K, Quevedo WC, Prota G, Fitzpatrick TB (1999) Biology of melanocytes. In I. M. Freedberg, A.Z. Eisen, K. Wolff, K.F. Austen, L.A. Goldsmith, S. I. Katz, T. B. Fitzpatrick (Eds.), Dermatology in General Medicine 5th ed., pp192- 220, New York, NY: McGraw Hill Role of Melanin-Advantages Melanin absorbs and scatters energy from UV and visible light to protect epidermal cells from UV damage Disadvantages Inflammation or injury to the skin is almost immediately accompanied by alteration in pigmentation Hyperpigmentation Hypopigmentation Dyschromias Post-Inflammatory hyperpigmentation Acne Melasma Lichen Planus Pigmentosus Progressive Macular Hypomelanosis -
Obstetrics and Gynecology Pretest® Self-Assessment and Review 10412 Wylen Fm.£.Qxd 6/18/03 10:55 AM Page Ii
10412_Wylen_fm.£.qxd 6/18/03 10:55 AM Page i PRE ® TEST Obstetrics and Gynecology PreTest® Self-Assessment and Review 10412_Wylen_fm.£.qxd 6/18/03 10:55 AM Page ii Notice Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The authors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the possibility of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the prod- uct information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs. 10412_Wylen_fm.£.qxd 6/18/03 10:55 AM Page iii PRE ® TEST Obstetrics and Gynecology PreTest® Self-Assessment and Review Tenth Edition Michele Wylen, M.D. -
3628-3641-Pruritus in Selected Dermatoses
Eur opean Rev iew for Med ical and Pharmacol ogical Sci ences 2016; 20: 3628-3641 Pruritus in selected dermatoses K. OLEK-HRAB 1, M. HRAB 2, J. SZYFTER-HARRIS 1, Z. ADAMSKI 1 1Department of Dermatology, University of Medical Sciences, Poznan, Poland 2Department of Urology, University of Medical Sciences, Poznan, Poland Abstract. – Pruritus is a natural defence mech - logical self-defence mechanism similar to other anism of the body and creates the scratch reflex skin sensations, such as touch, pain, vibration, as a defensive reaction to potentially dangerous cold or heat, enabling the protection of the skin environmental factors. Together with pain, pruritus from external factors. Pruritus is a frequent is a type of superficial sensory experience. Pruri - symptom associated with dermatoses and various tus is a symptom often experienced both in 1 healthy subjects and in those who have symptoms systemic diseases . Acute pruritus often develops of a disease. In dermatology, pruritus is a frequent simultaneously with urticarial symptoms or as an symptom associated with a number of dermatoses acute undesirable reaction to drugs. The treat - and is sometimes an auxiliary factor in the diag - ment of this form of pruritus is much easier. nostic process. Apart from histamine, the most The chronic pruritus that often develops in pa - popular pruritus mediators include tryptase, en - tients with cholestasis, kidney diseases or skin dothelins, substance P, bradykinin, prostaglandins diseases (e.g. atopic dermatitis) is often more dif - and acetylcholine. The group of atopic diseases is 2,3 characterized by the presence of very persistent ficult to treat . Persistent rubbing, scratching or pruritus. -
Melasma (1 of 8)
Melasma (1 of 8) 1 Patient presents w/ symmetric hyperpigmented macules, which can be confl uent or punctate suggestive of melasma 2 DIAGNOSIS No ALTERNATIVE Does clinical presentation DIAGNOSIS confirm melasma? Yes A Non-pharmacological therapy • Patient education • Camoufl age make-up • Sunscreen B Pharmacological therapy Monotherapy • Hydroquinone or • Tretinoin TREATMENT Responding to No treatment? See next page Yes Continue treatment © MIMSas required Not all products are available or approved for above use in all countries. Specifi c prescribing information may be found in the latest MIMS. B94 © MIMS 2019 Melasma (2 of 8) Patient unresponsive to initial therapy MELASMA A Non-pharmacological therapy • Patient education • Camoufl age make-up • Sunscreen B Pharmacological therapy Dual Combination erapy • Hydroquinone plus • Tretinoin or • Azelaic acid Responding to Yes Continue treatment treatment? as required No A Non-pharmacological therapy • Patient education • Camoufl age make-up • Sunscreen • Laser therapy • Dermabrasion B Pharmacological therapy Triple Combination erapy • Hydroquinone plus • Tretinoin plus • Topical steroid Chemical peels 1 MELASMA • Acquired hyperpigmentary skin disorder characterized by irregular light to dark brown macules occurring in the sun-exposed areas of the face, neck & arms - Occurs most commonly w/ pregnancy (chloasma) & w/ the use of contraceptive pills - Other factors implicated in the etiopathogenesis are photosensitizing medications, genetic factors, mild ovarian or thyroid dysfunction, & certain cosmetics • Most commonly aff ects Fitzpatrick skin phototypes III & IV • More common in women than in men • Rare before puberty & common in women during their reproductive years • Solar & ©ultraviolet exposure is the mostMIMS important factor in its development Not all products are available or approved for above use in all countries. -
Association Between First Caesarean Delivery and Adverse Outcomes In
Hu et al. BMC Pregnancy and Childbirth (2018) 18:273 https://doi.org/10.1186/s12884-018-1895-x RESEARCHARTICLE Open Access Association between first caesarean delivery and adverse outcomes in subsequent pregnancy: a retrospective cohort study Hong-Tao Hu1†, Jing-Jing Xu1†, Jing Lin1, Cheng Li1, Yan-Ting Wu2, Jian-Zhong Sheng3, Xin-Mei Liu4,5* and He-Feng Huang2,4,5* Abstract Background: Few studies have explored the association between a previous caesarean section (CS) and adverse perinatal outcomes in a subsequent pregnancy, especially in women who underwent a non-indicated CS in their first delivery. We designed this study to compare the perinatal outcomes of a subsequent pregnancy in women who underwent spontaneous vaginal delivery (SVD) or CS in their first delivery. Methods: This retrospective cohort study included women who underwent singleton deliveries at the International Peace Maternity and Child Health Hospital from January 2013 to December 2016. Data on the perinatal outcomes of all the women were extracted from the medical records. Multivariate logistic regression was conducted to assessed the association between CS in the first delivery and adverse perinatal outcomes in the subsequent pregnancy. Results: CS delivery in the subsequent pregnancy was more likely for women who underwent CS in their first birth than for women with previous SVD (97.3% versus 13.2%). CS in the first birth was also associated with a significantly increased risk of adverse outcomes in the subsequent pregnancy, especially in women who underwent a non- indicated CS. Adverse perinatal outcomes included pregnancy-induced hypertension [adjusted odds ratio (OR), 95% confidence interval (CI): 2.20, 1.59–3.05], gestational diabetes mellitus (1.82, 1.57–2.11), gestational anaemia (1.27, 1. -
Frequency of Different Types of Facial Melanoses Referring to the Department of Dermatology and Venereology, Nepal Medical Colle
Amatya et al. BMC Dermatology (2020) 20:4 https://doi.org/10.1186/s12895-020-00100-3 RESEARCH ARTICLE Open Access Frequency of different types of facial melanoses referring to the Department of Dermatology and Venereology, Nepal Medical College and Teaching Hospital in 2019, and assessment of their effect on health-related quality of life Bibush Amatya* , Anil Kumar Jha and Shristi Shrestha Abstract Background: Abnormalities of facial pigmentation, or facial melanoses, are a common presenting complaint in Nepal and are the result of a diverse range of conditions. Objectives: The objective of this study was to determine the frequency, underlying cause and impact on quality of life of facial pigmentary disorders among patients visiting the Department of Dermatology and Venereology, Nepal Medical College and Teaching Hospital (NMCTH) over the course of one year. Methods: This was a cross-sectional study conducted at the Department of Dermatology and Venereology, NMCT H. We recruited patients with facial melanoses above 16 years of age who presented to the outpatient department. Clinical and demographic data were collected and all the enrolled participants completed the validated Nepali version of the Dermatology Life Quality Index (DLQI). Results: Between January 5, 2019 to January 4, 2020, a total of 485 patients were recruited in the study. The most common diagnoses were melasma (166 patients) and post acne hyperpigmentation (71 patients). Quality of life impairment was highest in patients having melasma with steroid induced rosacea-like dermatitis (DLQI = 13.54 ± 1.30), while it was lowest in participants with ephelides (2.45 ± 1.23). Conclusion: Facial melanoses are a common presenting complaint and lead to substantial impacts on quality of life. -
Skin Care, Hair Care and Cosmetic Treatments in Pregnancy and Breastfeeding
Skin Care, Hair Care and Cosmetic Treatments in Pregnancy and Breastfeeding Information in this leaflet is general in nature and should not take the place of advice from your health care provider. With every pregnancy there is a 3 to 5% risk of having a baby with a birth defect. Issues for pregnancy Many pregnant women have skin and hair concerns just as they did before pregnancy. Sometimes conditions such as acne actually worsen during pregnancy because of hormonal changes and often women notice darkening of their skin (melasma). However, due to concern about potentially hazardous exposures to their unborn babies, pregnant women are often uncertain about which products are safe for them to use. Generally cosmetic treatments are discretionary (not medically necessary) and if safety is uncertain, women should consider whether the product or treatment is really required. There are several considerations when evaluating whether a specific skin or hair product is unsafe in pregnancy. Firstly, the active ingredient in the product needs to be considered unsafe. Secondly, it also has to be able to reach the unborn baby in its mother’s womb by inhalation or absorption through the mother’s skin (topical application). Although there is often limited information about the actual safety of specific ingredients in skin products during pregnancy, if it is known that skin absorption is minimal then the exposure to the unborn baby is generally insignificant and the product or treatment is regarded as safe. Below is a summary of current advice. Cosmetics, Moisturisers and other Skin Care Products Cosmetics and over the counter skin products generally contain ingredients that are unlikely to be harmful in pregnancy as they are used by applying to the skin (rather than swallowing a tablet). -
Managing the Risk of Uterine Rupture During a Trial of Labor After Cesarean Section
Managing the Risk of Uterine Rupture During a Trial of Labor After Cesarean Section By NORCAL Mutual Insurance Company Introduction While a successful vaginal birth after cesarean section (VBAC) is associated with less morbidity and mortality than repeat cesarean section (C-section), an unsuccessful VBAC is associated with a small but significant risk of uterine rupture that can result in death or serious injury to both the mother and the infant.1 When a trial of labor after C-section (TOLAC) ends in uterine rupture, emergency C-section, and the delivery of an infant with brain injuries, there is a good chance that the child’s This article originally appeared in the parents will file a lawsuit, or at least September 2011 issue of Claims Rx. It consider it. It should be noted that has been edited by Drs. Mark Zakowski, a plaintiff’s attorney is supposed to Patricia Dailey and Stephen Jackson prove duty (responsibility of the to meet the educational needs of physicians involved), negligence anesthesiologists, and is reprinted, as (care provided was below the changed, with permission. ©Copyright standard of care) and causation 2011, NORCAL Mutual Insurance Co. (negligence led to the injury) All Rights Reserved. Reproduction as well as injury. However, the permissible with written permission plaintiffs probably won’t focus on and credit. whether the standard of care was met, and their attorney might not either. In these types of cases, the degree of the infant’s brain injuries tends to over- shadow other liability issues. This can carry through to trial because juries are generally biased toward severely brain-injured infants and the parents who must provide for them. -
Managing Complications in Pregnancy and Childbirth Fetal
IMPAC FEtal distress in labour WHO Home | Reproductive Health Home | HRP | What's new | Resources | Contact | Search Department of Reproductive Health and Research (RHR), World Health Organization z Abbreviations Managing Complications in Pregnancy and Childbirth z Index A guide for midwives and doctors z List of diagnoses z MCPC Home Section 2 - Symptoms Clinical principles Rapid initial assessment Fetal distress in labour Talking with women and their families Emotional and psychological support PROBLEMS Emergencies z Abnormal fetal heart rate (less than 100 or more than 180 beats per minute). General care principles Clinical use of blood, blood products and z Thick meconium-stained amniotic fluid. replacement fluids Antibiotic therapy Anaesthesia and analgesia GENERAL MANAGEMENT Operative care principles z Prop up the woman or place her on her left side. Normal Labour and childbirth Newborn care principles z Stop oxytocin if it is being administered. Provider and community linkages ABNORMAL FETAL HEART RATE Symptoms BOX S-7 Abnormal fetal heart rate Shock Vaginal bleeding in early pregnancy z A normal fetal heart rate may slow during a contraction but usually recovers to normal as Vaginal bleeding in later pregnancy and soon as the uterus relaxes. labour z A very slow fetal heart rate in the absence of contractions or persisting after contractions is Vaginal bleeding after childbirth suggestive of fetal distress. Headache, blurred vision, convulsions or loss of consciousness, elevated blood z A rapid fetal heart rate may be a response to maternal fever, drugs causing rapid maternal pressure heart rate (e.g. tocolytic drugs), hypertension or amnionitis. In the absence of a rapid maternal Unsatisfactory progress of Labour heart rate, a rapid fetal heart rate should be considered a sign of fetal distress. -
A New Insight on Atopic Skin Diathesis: Is It Correlated with the Severity of Melasma
A New Insight on Atopic Skin Diathesis: Is It Correlated with the Severity of Melasma Danar Wicaksono1*, Rima Mustafa2, Sri Awalia Febriana1, Kristiana Etnawati1 1 Dermatovenereology Department, Faculty of Medicine Universitas Gadjah Mada – Dr. Sardjito General Hospital, Yogyakarta-Indonesia 2 Clinical Epidemiology and Biostatistics Unit, Faculty of Medicine Universitas Gadjah Mada –Dr. Sardjito General Hospital, Yogyakarta-Indonesia Keywords: Melasma, atopic skin diathesis (ASD), MASI score, atopic dermatitis (AD) Abstract: Melasma is a macular lesion of light brown to dark on the sun-exposed area, especially on the face. Atopic Skin Diathesis (ASD) is a clinical term to describe skin atopics with previous, present or future atopic dermatitis (AD). Dennie-Morgan infraorbital folds are secondary creases in the skin below the lower eyelids with a sensitivity of 78% and a specificity of 76% to diagnose AD. Melasma skin is characterized by impaired stratum corneum integrity and a delayed barrier recovery rate. Barrier dysfunction will stimulate keratinocyte to secrete keratinocyte-derived factor, which plays role in skin pigmentation process in melasma. To analyze correlation between ASD and Melasma Area Severity Index (MASI) score in melasma patient. This study is an observational analytic study with cross sectional design. Measurement of ASD and MASI score were done in 60 subjects with melasma who went to dermatology outpatient clinic Dr. Sardjito General Hospital from July 2017 to Januari 2018. The correlation between ASD and MASI score was analyzed using Pearson correlation. The result of this study showed no significant correlation between ASD and MASI scores (r: 0.02, p: 0,85). Crude Relative Risk (RR) for Dennie-Morgan infraorbital folds and MASI score was 4 (1.01-15.87). -
Atopic Eruption of Pregnancy: a Recent, but Controversial Classification
Open Access Austin Journal of Dermatology A Austin Full Text Article Publishing Group Review Article Atopic Eruption of Pregnancy: A Recent, but Controversial Classification Resende C1*, Braga A2, Vieira AP1 and Brito C1 Abstract 1Department of Dermatology and Venereology, Hospital de Braga, Portugal Introduction: Atopic Eruption of Pregnancy (AEP) has recently been 2Department of Obstetrics and Gynecology, Centro introduced as a new disease complex in a recent reclassification and it is the Materno-Infantil do Norte, Portugal most common dermatosis of pregnancy. It encompasses Atopic Eczema (AE), *Corresponding author: Cristina Resende, Prurigo of Pregnancy (PP) and Pruritic Folliculitis in Pregnancy (PFP). Department of Dermatology and Venereology, Hospital Material and methods: The authors carried out a literature search in de Braga, Sete Fontes – São Victor, PT-4710-243 Medline using Pub med, investigating what is presently known about the Braga, Portugal. Tel: +351253 027 000; Fax: +351 253 classification, etiopathogenesis, diagnosis, management and prognosis of AEP. 027 999; Email: [email protected] Results: AE during pregnancy includes women who already have eczema, Received: May 12, 2014; Accepted: June 11, 2014; but experience an exacerbation of the disease during pregnancy and women Published: June 13, 2014 with their first manifestation of AE during pregnancy. The biases T cell immunity towards a type 2 T helper response is important for continuation of a normal pregnancy, but worsens the imbalance already present in most atopic patients. About 25% of patients improve and more than 50% experience deterioration during pregnancy. PP has been reported in all trimesters of pregnancy and has been associated with obstetric cholestasis in women with an atopic background. -
00005721-201907000-00003.Pdf
2.0 ANCC Contact Hours Angela Y. Stanley, DNP, APRN-BC, PHCNS-BC, NEA-BC, RNC-OB, C-EFM, Catherine O. Durham, DNP, FNP-BC, James J. Sterrett, PharmD, BCPS, CDE, and Jerrol B. Wallace, DNP, MSN, CRNA SAFETY OF Over-the-Counter MEDICATIONS IN PREGNANCY Abstract Approximately 90% of pregnant women use medications while they are pregnant including both over-the-counter (OTC) and prescription medications. Some medica- tions can pose a threat to the pregnant woman and fetus with 10% of all birth defects directly linked to medications taken during pregnancy. Many medications have docu- mented safety for use during pregnancy, but research is limited due to ethical concerns of exposing the fetus to potential risks. Much of the information gleaned about safety in pregnancy is collected from registries, case studies and reports, animal studies, and outcomes management of pregnant women. Common OTC categories of readily accessible medications include antipyretics, analgesics, nonsteroidal anti- infl ammatory drugs, nasal topicals, antihistamines, decongestants, expectorants, antacids, antidiar- rheal, and topical dermatological medications. We review the safety categories for medications related to pregnancy and provide an overview of OTC medications a pregnant woman may consider for management of common conditions. Key words: Pharmacology; Pregnancy; Safety; Self-medication. Shutterstock 196 volume 44 | number 4 July/August 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved. he increased prevalence of pregnant women identifi ed risks in animal-reproduction studies or completed taking medications, including over-the-counter animal studies show no harm. The assignment of Category (OTC) medications presents a challenge to C has two indications; (1) limited or no research has been nurses providing care to women of childbear- conducted about use in pregnancy, and (2) animal studies ing age.