March 16, 2010 u vol. 107 u no. 11 u 4791–5262

Cover image: Pictured are two mouse pancreatic islets of Langerhans. A typical wild-type islet (right panel) consists of a core of insulin-producing beta cells (in green) with peripheral glu- cagon producing alpha cells (in red). The islet from a type 1 diabetic mouse model (left) shows near-complete loss of beta cell mass and an abundance of glucagon-producing alpha cells. The imbalance between the two cell types contributes to the glucose abnormalities characteristic of type 1 diabetes. May-Yun Wang et al. suggest that leptin administration may have advantages over insulin monotherapy as a therapy for type 1 diabetes. See the Feature Article by Wang et al. on pages 4813–4819. Image courtesy of Gregory Clark and Philipp Scherer (Touchstone Diabetes Center, University of Texas Southwestern Medical Center). From the Cover

4813 Leptin treatment for diabetes 4857 Racial bias in friendships 5124 Targeting myeloma bone disease 5190 Nicotine accumulation and the brain 5238 Inherited cognitive abilities

E38 Revision of the mtDNA tree and corresponding Contents haplogroup nomenclature Mannis van Oven E40 Reply to van Oven: Suggestions and caveats for naming THIS WEEK IN PNAS mtDNA haplogroup Qing-Peng Kong, Hans-Jürgen Bandelt, Mian Zhao, Ya-Ping 4791 In This Issue Zhang, and Yong-Gang Yao

COMMENTARIES LETTERS (ONLINE ONLY) 4793 Leveraging leptin for type I diabetes? Daniel Kraus, Mark A. Herman, and Barbara B. Kahn E33 New evidence for a Mesoamerican homeland for Proto- See companion article on page 4813 Uto-Aztecan Jane H. Hill 4795 A strong role for nature in face recognition Elinor McKone and Romina Palermo E34 Lack of linguistic support for Proto-Uto-Aztecan at 8900 BP See companion article on page 5238 Cecil H. Brown

E35 Reply to Hill and Brown: Maize and Uto-Aztecan cultural history PERSPECTIVE William L. Merrill, Robert J. Hard, Jonathan B. Mabry, Gayle J. Fritz, Karen R. Adams, John R. Roney, 4797 New perspectives on anthropoid origins and A. C. MacWilliams Blythe A. Williams, Richard F. Kay, and E. Christopher Kirk E37 Reply to Rocke and Barker: The question is not whether birds are affected by thiamine deficiency or botulism, it is about the order of events Lennart Balk, Per-Åke Hägerroth, Gun Åkerman, Marsha INAUGURAL ARTICLE Hanson, Ulla Tjärnlund, Tomas Hansson, Gunnar Thor Hallgrimsson, Yngve Zebühr, Dag Broman, Torsten Mörner, 4805 Four generations of transition-state analogues for and Henrik Sundberg human purine nucleoside phosphorylase Meng-Chiao Ho, Wuxian Shi, Agnes Rinaldo-Matthis, Peter C. Tyler, Gary B. Evans, Keith Clinch, Steven C. Almo, Free online through the PNAS open access option. and Vern L. Schramm

PNAS u March 16, 2010 u vol. 107 u no. 11 u iii–viii Downloaded by guest on September 24, 2021 FEATURE ARTICLE SOCIAL SCIENCES

4813 Leptin therapy in insulin-deficient type I diabetes ANTHROPOLOGY May-yun Wang, Lijun Chen, Gregory O. Clark, Young 4851 The imprint of China’s first emperor on the distant realm Lee, Robert D. Stevens, Olga R. Ilkayeva, Brett R. Wenner, of eastern Shandong James R. Bain, Maureen J. Charron, Christopher B. Gary M. Feinman, Linda M. Nicholas, and Fang Hui Newgard, and Roger H. Unger See Commentary on page 4793 ECONOMIC SCIENCES 4857 Identifying the roles of race-based choice and chance in high school friendship network formation PHYSICAL SCIENCES Sergio Currarini, Matthew O. Jackson, and Paolo Pin

APPLIED PHYSICAL SCIENCES 4862 Interaction of natural survival instincts and internalized social norms exploring the Titanic and Lusitania fl fl 4820 Discovering the ight autostabilizer of fruit ies by disasters inducing aerial stumbles Bruno S. Frey, David A. Savage, and Benno Torgler Leif Ristroph, Attila J. Bergou, Gunnar Ristroph, Katherine Coumes, Gordon J. Berman, John Guckenheimer, Z. Jane Wang, and Itai Cohen PSYCHOLOGICAL AND COGNITIVE SCIENCES 4866 The dimensionality of discourse CHEMISTRY Isidoros Doxas, Simon Dennis, and William L. Oliver

4825 Stimulated coherent anti-Stokes Raman spectroscopy 5232 Optimal reward harvesting in complex perceptual (CARS) resonances originate from double-slit environments interference of two-photon Stokes pathways Vidhya Navalpakkam, Christof Koch, Antonio Rangel, Saar Rahav and Shaul Mukamel and Pietro Perona 4830 An atomistic picture of the regeneration process in dye sensitized solar cells 5248 Theta-activity in anterior cingulate cortex predicts task Florian Schiffmann, Joost VandeVondele, Jürg Hutter, rules and their adjustments following errors Atsushi Urakawa, Ronny Wirz, and Alfons Baiker Thilo Womelsdorf, Kevin Johnston, Martin Vinck, and Stefan Everling 4878 Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124 Douglas S. Auld, Scott Lovell, Natasha Thorne, Wendy A. Lea, David J. Maloney, Min Shen, Ganesha Rai, Kevin P. BIOLOGICAL SCIENCES Battaile, Craig J. Thomas, Anton Simeonov, Robert P. Hanzlik, and James Inglese APPLIED BIOLOGICAL SCIENCES 4955 An unlocking/relocking barrier in conformational 4820 Discovering the flight autostabilizer of fruit flies by fluctuations of villin headpiece subdomain inducing aerial stumbles Andreas Reiner, Peter Henklein, and Thomas Kiefhaber Leif Ristroph, Attila J. Bergou, Gunnar Ristroph, Katherine Coumes, Gordon J. Berman, John Guckenheimer, Z. Jane Wang, and Itai Cohen ENGINEERING 4834 Magnetically driven three-dimensional manipulation 4872 Geometric cues for directing the differentiation of and inductive heating of magnetic-dispersion mesenchymal stem cells containing metal alloys Kristopher A. Kilian, Branimir Bugarija, Bruce T. Lahn, Joshua D. Calabro, Xu Huang, Brian G. Lewis, and Milan Mrksich and Ainissa G. Ramirez

BIOCHEMISTRY ENVIRONMENTAL SCIENCES 4805 Four generations of transition-state analogues for 5036 Tropical cloud forest climate variability and the demise human purine nucleoside phosphorylase of the Monteverde golden toad Meng-Chiao Ho, Wuxian Shi, Agnes Rinaldo-Matthis, Peter Kevin J. Anchukaitis and Michael N. Evans C. Tyler, Gary B. Evans, Keith Clinch, Steven C. Almo, and Vern L. Schramm

MATHEMATICS 4878 Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124 4840 Kadison–Singer algebras, II: General case Douglas S. Auld, Scott Lovell, Natasha Thorne, Wendy A. Liming Ge and Wei Yuan Lea, David J. Maloney, Min Shen, Ganesha Rai, Kevin P. 4845 Analytic index for a family of Dirac–Ramond operators Battaile, Craig J. Thomas, Anton Simeonov, Robert P. Orlando Alvarez and Paul Windey Hanzlik, and James Inglese

iv u www.pnas.org Downloaded by guest on September 24, 2021 4884 Full-length extracellular region of the var2CSA variant 4961 Large-scale conformational sampling of proteins using of PfEMP1 is required for specific, high-affinity binding temperature-accelerated molecular dynamics to CSA Cameron F. Abrams and Eric Vanden-Eijnden Anand Srivastava, Stéphane Gangnard, Adam Round, 4967 4.0-Å resolution cryo-EM structure of the mammalian Sébastien Dechavanne, Alexandre Juillerat, Bertrand Raynal, chaperonin TRiC/CCT reveals its unique subunit Grazyna Faure, Bruno Baron, Stéphanie Ramboarina, arrangement Saurabh Kumar Singh, Hassan Belrhali, Patrick England, Anita Lewit-Bentley, Artur Scherf, Graham A. Bentley, Yao Cong, Matthew L. Baker, Joanita Jakana, David Woolford, Erik J. Miller, Stefanie Reissmann, Ramya N. and Benoît Gamain Kumar, Alyssa M. Redding-Johanson, Tanveer S. Batth, 4890 Circadian control of XPA and excision repair of Aindrila Mukhopadhyay, Steven J. Ludtke, Judith cisplatin-DNA damage by cryptochrome and HERC2 Frydman, and Wah Chiu ubiquitin ligase 4973 A ratchet mechanism for amplification in low-frequency Tae-Hong Kang, Laura A. Lindsey-Boltz, Joyce T. mammalian hearing Reardon, and Aziz Sancar Tobias Reichenbach and A. J. Hudspeth 4896 Pore architecture of the ORAI1 store-operated 4979 Random cell movement promotes synchronization of the calcium channel segmentation clock Yubin Zhou, Sweta Ramachandran, Masatsugu Oh-hora, Anjana Rao, and Patrick G. Hogan Koichiro Uriu, Yoshihiro Morishita, and Yoh Iwasa 4902 The antiapoptotic DeltaNp73 is degraded in a 4985 Minute negative superhelicity is sufficient to induce the c-Jun–dependent manner upon genotoxic stress B-Z transition in the presence of low tension through the antizyme-mediated pathway Mina Lee, Sook Ho Kim, and Seok-Cheol Hong Iqbal Dulloo, Ganesan Gopalan, Gerry Melino, 4991 Strong intranucleoid interactions organize the and Kanaga Sabapathy Escherichia coli chromosome into a nucleoid filament 4908 Picomole-scale characterization of protein stability and Paul A. Wiggins, Keith C. Cheveralls, Joshua S. Martin, function by quantitative cysteine reactivity Robert Lintner, and Jané Kondev Daniel G. Isom, Eyal Vardy, Terrence G. Oas, 4996 Ca 1.2 β-subunit coordinates CaMKII-triggered and Homme W. Hellinga V cardiomyocyte death and afterdepolarizations 4914 Engineering cis-telomerase RNAs that add telomeric Olha M. Koval, Xiaoquan Guan, Yuejin Wu, Mei-ling Joiner, repeats to themselves Zhan Gao, Biyi Chen, Isabella M. Grumbach, Elizabeth D. Feng Qiao, Karen J. Goodrich, and Thomas R. Cech Luczak, Roger J. Colbran, Long-Sheng Song, Thomas J. Hund, Peter J. Mohler, and Mark E. Anderson 4919 Identification and characterization of the furfural and 5-(hydroxymethyl)furfural degradation pathways of 5001 Atomically detailed simulation of the recovery stroke in Cupriavidus basilensis HMF14 myosin by Milestoning Frank Koopman, Nick Wierckx, Johannes H. de Winde, Ron Elber and Anthony West and Harald J. Ruijssenaars 4925 The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo CELL BIOLOGY Minmin Liu, Viswanath Bandaru, Jeffrey P. Bond, Pawel 5006 Initiation of DNA replication after fertilization is Jaruga, Xiaobei Zhao, Plamen P. Christov, Cynthia J. Burrows, regulated by p90Rsk at pre-RC/pre-IC transition in Carmelo J. Rizzo, Miral Dizdaroglu, and Susan S. Wallace starfish eggs 4931 Allosteric modulation of Ras positions Q61 for a direct Kazunori Tachibana, Masashi Mori, Takashi Matsuhira, role in catalysis Tomotake Karino, Takuro Inagaki, Ai Nagayama, Atsuya Greg Buhrman, Genevieve Holzapfel, Susan Fetics, Nishiyama, Masatoshi Hara, and Takeo Kishimoto and Carla Mattos 5012 Dose-dependent induction of distinct phenotypic 4937 Origins of catalysis by computationally designed responses to Notch pathway activation in mammary retroaldolase enzymes epithelial cells Jonathan K. Lassila, David Baker, and Daniel Herschlag Marco Mazzone, Laura M. Selfors, John Albeck, Michael Overholtzer, Sanja Sale, Danielle L. Carroll, Darshan 4943 A zinc-binding site by negative selection induces Pandya, Yiling Lu, Gordon B. Mills, Jon C. Aster, Spyros metallodrug susceptibility in an essential chaperonin Artavanis-Tsakonas, and Joan S. Brugge Shujian Cun and Hongzhe Sun 5018 Drosophila Parkin requires PINK1 for mitochondrial 4949 Abundant ribonucleotide incorporation into DNA by translocation and ubiquitinates Mitofusin yeast replicative polymerases Elena Ziviani, Ran N. Tao, and Alexander J. Whitworth Stephanie A. Nick McElhinny, Brian E. Watts, Dinesh Kumar, Danielle L. Watt, Else-Britt Lundström, Peter M. J. Burgers, Erik Johansson, Andrei Chabes, and Thomas A. Kunkel DEVELOPMENTAL BIOLOGY 5024 Developmental hyperbilirubinemia and CNS toxicity in BIOPHYSICS AND COMPUTATIONAL BIOLOGY mice humanized with the UDP glucuronosyltransferase 4955 An unlocking/relocking barrier in conformational 1 (UGT1) locus fluctuations of villin headpiece subdomain Ryoichi Fujiwara, Nghia Nguyen, Shujuan Chen, Andreas Reiner, Peter Henklein, and Thomas Kiefhaber and Robert H. Tukey

PNAS u March 16, 2010 u vol. 107 u no. 11 u v Downloaded by guest on September 24, 2021 ECOLOGY IMMUNOLOGY 5030 Macroecological signals of species interactions in the 5088 Seromic profiling of ovarian and pancreatic cancer Danish avifauna Sacha Gnjatic, Erika Ritter, Markus W. Büchler, Nathalia A. Nicholas J. Gotelli, Gary R. Graves, and Carsten Rahbek Giese, Benedikt Brors, Claudia Frei, Anne Murray, Niels Halama, Inka Zörnig, Yao-Tseng Chen, Christopher ENVIRONMENTAL SCIENCES Andrews, Gerd Ritter, Lloyd J. Old, Kunle Odunsi, and Dirk Jäger 5036 Tropical cloud forest climate variability and the demise of the Monteverde golden toad 5094 Evidence for a functional sidedness to the αβTCR Kevin J. Anchukaitis and Michael N. Evans Michael S. Kuhns, Andrew T. Girvin, Lawrence O. Klein, Rebecca Chen, Kirk D. C. Jensen, Evan W. Newell, Johannes B. Huppa, Björn F. Lillemeier, Morgan EVOLUTION Huse, Yueh-hsiu Chien, K. Christopher Garcia, 5041 Population genetics of ecological communities with DNA and Mark M. Davis barcodes: An example from New Guinea Lepidoptera Kathleen J. Craft, Steffen U. Pauls, Karolyn Darrow, Scott E. 5100 Interaction of C-type lectin-like receptors NKp65 Miller, Paul D. N. Hebert, Lauren E. Helgen, Vojtech and KACL facilitates dedicated immune recognition Novotny, and George D. Weiblen of human keratinocytes Jessica Spreu, Sabrina Kuttruff, Veronika Stejfova, 5047 A single mutation in the first transmembrane domain of Kevin M. Dennehy, Birgit Schittek, and Alexander Steinle yeast COX2 enables its allotopic expression Lubica Supekova, Frantisek Supek, John E. Greer, and Peter G. Schultz MEDICAL SCIENCES 5053 Complete mitochondrial genome of a Pleistocene 4813 Leptin therapy in insulin-deficient type I diabetes jawbone unveils the origin of polar bear May-yun Wang, Lijun Chen, Gregory O. Clark, Young Charlotte Lindqvist, Stephan C. Schuster, Yazhou Sun, Lee, Robert D. Stevens, Olga R. Ilkayeva, Brett R. Wenner, Sandra L. Talbot, Ji Qi, Aakrosh Ratan, Lynn P. Tomsho, James R. Bain, Maureen J. Charron, Christopher B. Lindsay Kasson, Eve Zeyl, Jon Aars, Webb Miller, Ólafur Newgard, and Roger H. Unger Ingólfsson, Lutz Bachmann, and Øystein Wiig See Commentary on page 4793 5058 Polygenic and directional regulatory evolution across 5106 Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T pathways in Saccharomyces lineage leukemogenesis and modulate responses to James H. Bullard, Yulia Mostovoy, Sandrine Dudoit, targeted agents and Rachel B. Brem Monique Dail, Qing Li, Andrew McDaniel, Jason Wong, Keiko Akagi, Ben Huang, Hio Chung Kang, Scott C. GENETICS Kogan, Kevan Shokat, Linda Wolff, Benjamin S. Braun, and Kevin Shannon 5064 Evolution of species-specific promoter-associated mechanisms for protecting chromosome ends by 5112 From combinatorial peptide selection to drug prototype Drosophila Het-A telomeric transposons (I): Targeting the vascular endothelial growth factor Karen L. Traverse, Janet A. George, P. G. DeBaryshe, receptor pathway and Mary-Lou Pardue Ricardo J. Giordano, Marina Cardó-Vila, Ahmad Salameh, Cristiane D. Anobom, Benjamin D. Zeitlin, David H. Hawke, 5070 Functional analysis of human mismatch repair gene Ana P. Valente, Fábio C. L. Almeida, Jacques E. Nör, fi mutations identi es weak alleles and polymorphisms Richard L. Sidman, Renata Pasqualini, and Wadih Arap capable of polygenic interactions Sandra L. Martinez and Richard D. Kolodner 5118 From combinatorial peptide selection to drug prototype (II): Targeting the epidermal growth factor receptor 5076 Abnormal development of the cerebral cortex and pathway fi cerebellum in the setting of lamin B2 de ciency Marina Cardó-Vila, Ricardo J. Giordano, Richard L. Sidman, fi Catherine Cof nier, Sandy Y. Chang, Chika Nobumori, Lawrence F. Bronk, Zhen Fan, John Mendelsohn, Wadih Yiping Tu, Emily A. Farber, Julia I. Toth, Loren G. Fong, Arap, and Renata Pasqualini and Stephen G. Young 5124 Activin A promotes multiple myeloma-induced 5082 A genome-wide association study of alcohol osteolysis and is a promising target for myeloma bone dependence disease Laura J. Bierut, Arpana Agrawal, Kathleen K. Bucholz, Sonia Vallet, Siddhartha Mukherjee, Nileshwari Vaghela, Kimberly F. Doheny, Cathy Laurie, Elizabeth Pugh, Sherri Teru Hideshima, Mariateresa Fulciniti, Samantha Pozzi, Fisher, Louis Fox, William Howells, Sarah Bertelsen, Anthony Loredana Santo, Diana Cirstea, Kishan Patel, Aliyah R. L. Hinrichs, Laura Almasy, Naomi Breslau, Robert C. Sohani, Alex Guimaraes, Wanling Xie, Dharminder Culverhouse, Danielle M. Dick, Howard J. Edenberg, Tatiana Chauhan, Jesse A. Schoonmaker, Eyal Attar, Michael Foroud, Richard A. Grucza, Dorothy Hatsukami, Victor Churchill, Edie Weller, Nikhil Munshi, Jasbir S. Seehra, Hesselbrock, Eric O. Johnson, John Kramer, Robert F. Ralph Weissleder, Kenneth C. Anderson, David T. Krueger, Samuel Kuperman, Michael Lynskey, Karl Mann, Scadden, and Noopur Raje Rosalind J. Neuman, Markus M. Nöthen, John I. Nurnberger, Jr., Bernice Porjesz, Monika Ridinger, Nancy L. Saccone, Scott 5130 Sensitivity of MRI resonance frequency to the F. Saccone, Marc A. Schuckit, Jay A. Tischfield, Jen C. Wang, orientation of brain tissue microstructure Marcella Rietschel, Alison M. Goate, and John P. Rice, Jongho Lee, Karin Shmueli, Masaki Fukunaga, Peter as part of the Gene, Environment Association Studies van Gelderen, Hellmut Merkle, Afonso C. Silva, (GENEVA) Consortium and Jeff H. Duyn

vi u www.pnas.org Downloaded by guest on September 24, 2021 5136 LRP6 overexpression defines a class of breast cancer 5196 Distal axonopathy with structural persistence in subtype and is a target for therapy glaucomatous neurodegeneration Chia-Chen Liu, Julie Prior, David Piwnica-Worms, Samuel D. Crish, Rebecca M. Sappington, Denise M. Inman, and Guojun Bu Philip J. Horner, and David J. Calkins

5142 Allele-specific tumor spectrum in Pten knockin mice 5202 Axon guidance by growth-rate modulation Hui Wang, Matt Karikomi, Shan Naidu, Ravi Rajmohan, Duncan Mortimer, Zac Pujic, Timothy Vaughan, Enrico Caserta, Hui-Zi Chen, Maysoon Rawahneh, Julie Andrew W. Thompson, Julia Feldner, Irina Vetter, Moffitt, Julie A. Stephens, Soledad A. Fernandez, Michael and Geoffrey J. Goodhill Weinstein, Danxin Wang, Wolfgang Sadee, Krista La Perle, Paul Stromberg, Thomas J. Rosol, Charis Eng, Michael C. Ostrowski, and Gustavo Leone PHYSIOLOGY 5208 Loss of high-frequency glucose-induced Ca2+ oscillations 5148 Pain perception is altered by a nucleotide polymorphism in pancreatic islets correlates with impaired glucose in SCN9A tolerance in Trpm5−/− mice Frank Reimann, James J. Cox, Inna Belfer, Luda Diatchenko, Barbara Colsoul, Anica Schraenen, Katleen Lemaire, Roel Dmitri V. Zaykin, Duncan P. McHale, Joost P. H. Drenth, Quintens, Leentje Van Lommel, Andrei Segal, Grzegorz Feng Dai, Jerry Wheeler, Frances Sanders, Linda Wood, Owsianik, Karel Talavera, Thomas Voets, Robert F. Tian-Xia Wu, Jaro Karppinen, Lone Nikolajsen, Minna Margolskee, Zaza Kokrashvili, Patrick Gilon, Bernd Nilius, Männikkö, Mitchell B. Max, Carly Kiselycznyk, Minakshi Frans C. Schuit, and Rudi Vennekens Poddar, Rene H. M. te Morsche, Shad Smith, Dustin Gibson, Anthi Kelempisioti, William Maixner, Fiona M. Gribble, and C. Geoffrey Woods PLANT BIOLOGY 5214 A developmental framework for endodermal differentiation and polarity MICROBIOLOGY Julien Alassimone, Sadaf Naseer, and Niko Geldner 5154 Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium 5220 Polar localization and degradation of Arabidopsis fi tuberculosis boron transporters through distinct traf cking Blair R. G. Gordon, Yifei Li, Linru Wang, Anna Sintsova, pathways Harm van Bakel, Songhai Tian, William Wiley Navarre, Bin Junpei Takano, Mayuki Tanaka, Atsushi Toyoda, Kyoko Xia, and Jun Liu Miwa, Koji Kasai, Kentaro Fuji, Hitoshi Onouchi, Satoshi Naito, and Toru Fujiwara 5160 A link between the assembly of flagella and lipooligosaccharide of the Gram-negative bacterium 5226 Phosphoenolpyruvate carboxylase intrinsically located Campylobacter jejuni in the chloroplast of rice plays a crucial role in Thomas W. Cullen and M. Stephen Trent ammonium assimilation Chisato Masumoto, Shin-Ichi Miyazawa, Hiroshi Ohkawa, 5166 Susceptibility of xenotropic murine leukemia virus- Takuya Fukuda, Yojiro Taniguchi, Seiji Murayama, related virus (XMRV) to retroviral restriction factors Miyako Kusano, Kazuki Saito, Hiroshi Fukayama, Harriet C. T. Groom, Melvyn W. Yap, Rui Pedro Galão, and Mitsue Miyao Stuart J. D. Neil, and Kate N. Bishop

PSYCHOLOGICAL AND COGNITIVE SCIENCES NEUROSCIENCE 5232 Optimal reward harvesting in complex perceptual 5172 In vivo vomeronasal stimulation reveals sensory environments encoding of conspecific and allospecific cues by the Vidhya Navalpakkam, Christof Koch, Antonio Rangel, mouse accessory olfactory bulb and Pietro Perona Y. Ben-Shaul, L. C. Katz, R. Mooney, and C. Dulac 5238 Human face recognition ability is specific and 5178 Reduced voltage sensitivity in a K+-channel voltage highly heritable sensor by electric field remodeling Jeremy B. Wilmer, Laura Germine, Christopher F. Vivian González-Pérez, Katherine Stack, Katica Boric, Chabris, Garga Chatterjee, Mark Williams, Eric Loken, and David Naranjo Ken Nakayama, and Bradley Duchaine See Commentary on page 4795 5184 Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host SUSTAINABILITY SCIENCE Johan Jäderstad, Linda M. Jäderstad, Jianxue Li, Satyan 5242 Ecosystem service bundles for analyzing tradeoffs in Chintawar, Carmen Salto, Massimo Pandolfo, Vaclav diverse landscapes Ourednik, Yang D. Teng, Richard L. Sidman, Ernest Arenas, C. Raudsepp-Hearne, G. D. Peterson, and E. M. Bennett Evan Y. Snyder, and Eric Herlenius 5190 Kinetics of brain nicotine accumulation in dependent and nondependent smokers assessed with PET and cigarettes SYSTEMS BIOLOGY containing 11C-nicotine 5248 Theta-activity in anterior cingulate cortex predicts task Jed E. Rose, Alexey G. Mukhin, Stephen J. Lokitz, Timothy G. rules and their adjustments following errors Turkington, Joseph Herskovic, Frederique M. Behm, Sudha Thilo Womelsdorf, Kevin Johnston, Martin Vinck, Garg, and Pradeep K. Garg and Stefan Everling

PNAS u March 16, 2010 u vol. 107 u no. 11 u vii Downloaded by guest on September 24, 2021 5254 Dynamic transcriptomes during neural differentiation of MICROBIOLOGY human embryonic stem cells revealed by short, long, 5260 Intramolecular amide bonds stabilize pili on the surface and paired-end sequencing of bacilli Jia Qian Wu, Lukas Habegger, Parinya Noisa, Anna Szekely, Jonathan M. Budzik, Catherine B. Poor, Kym F. Faull, Julian Caihong Qiu, Stephen Hutchison, Debasish Raha, Michael P. Whitelegge, Chuan He, and Olaf Schneewind Egholm, Haifan Lin, Sherman Weissman, Wei Cui, Mark Gerstein, and Michael Snyder

CORRECTIONS RETRACTION

PSYCHOLOGICAL AND COGNITIVE SCIENCES 5260 Eye movement evidence that readers maintain BIOCHEMISTRY and act on uncertainty about past linguistic input 5261 Triplex-forming oligonucleotide-orthophenanthroline Roger Levy, Klinton Bicknell, Tim Slattery, conjugates for efficient targeted genome modification and Keith Rayner Fabio Cannata, Erika Brunet, Loïc Perrouault, Victoria Roig, Slimane Ait-Si-Ali, Ulysse Asseline, Jean-Paul Concordet, BIOCHEMISTRY and Carine Giovannangeli 5260 Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility Jillian Orans, Michael D. L. Johnson, Kimberly A. Coggan, ix Author Index Justin R. Sperlazza, Ryan W. Heiniger, Matthew C. Wolfgang, and Matthew R. Redinbo xii Subscription Form

viii u www.pnas.org Downloaded by guest on September 24, 2021