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FORMULARI UBAT-UBATAN HOSPITAL KEMAMAN (Pindaan 1/2020)

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FORMULARI UBAT-UBATAN HOSPITAL KEMAMAN (Pindaan 1/2020) FORMULARI UBAT-UBATAN HOSPITAL KEMAMAN (Pindaan 1/2020) Generic Name Prescriber Indications Dosage Adverse Reaction Contraindications Interactions Precautions Category Abacavir Sulphate 600 mg and A* Antiretroviral combination therapy of HIV ADULTS & ADOLESCENT (> 12 years of Hypersensitivity, anorexia, headache, Hypersensitivity reaction to the active Co-trimoxazole, methadone, Close monitoring is required in patients Lamivudine 300 mg Tablet infection in adults and adolescents from age): Recommended dose is one tablet insomnia, cough, nasal symptoms, substance or to any excipients, severe ribavirin with mild and moderate hepatic 12 years of age with the following once daily. Not to be used in adults or nausea, vomiting, abdominal pain or hepatic impairment impairment. Discontinue treatment criteria: adolescents weigh less than 40kg. cramps, diarrhea, rash, alopecia, fever, immediately if hypersensitivity is i)Patients unsuitable or failed other CHILDREN : Not recommended lethargy, fatigue, malaise. suspected. Not recommended in patients HAART treatment ii)Patients who are at with creatinine clearance < 50ml/min high risk of renal impairment iii)Patients with osteoporosis or at high risk of bone loss Acetazolamide 250 mg Tablet B Reduction of intraocular pressure in open- 250mg 1-4 times a day, the dosage being Nausea, vomiting, diarrhoea, taste Hypokalaemia, hyponatraemia, Aspirin, cyclosporin, digitalis , Caution in patients with adrenal failure or angle glaucoma, secondary glaucoma titrated according to patient response disturbances, loss of appetite, hyperchloraemic acidosis, severe hepatic digoxin, lithium, phenytoin, Addisons disease; diabetis mellitus; and peri-operatively in angle-closure paraesthesia, flushing, headache, impairment, renal impairment, thiazide quinidine, topiramate hypokalemia, hyponatremia or other glaucoma dizziness, fatigue, irritability, depression, or sulphonamide hypersensitivity. Best electrolyte imbalance; respiratory or thirst, polyuria, reduced libido, metabolic avoided in the first trimester of hypochloraemic acidosis; hepatic or renal acidosis and electrolyte disturbances on pregnancy. Should not be used in chronic function impairment. Maintenance of long-term therapy noncongestive closed-angle glaucoma high fluid intake may be advisable, especially in patients with hypercalciuria or gout, to reduce the risk of renal calculi. Care should be taken if potassium supplementation is indicated. Caution in elderly, pregnancy and lactation, Stevens- Johnson syndrome, toxic epidermal necrosis, high-dose aspirin Acetylsalicylic Acid 100 mg, Glycine B Prevention of myocardial infarct, stroke, 1 tablet daily Nausea, vomiting, dyspepsia, GI Bleeding disorders. Hypersensitivity to Alcohol, dipyridamole, Dyspepsia, gastric mucosal lesions, 45 mg Tablet vascular occlusion and deep vein ulceration, haematemesis, malaena. salicylate metoclopramide, metoprolol, haemorrhagic disorders, gout, intolerant thrombosis. Transient ischaemic attacks Occasionally hepatotoxicity carbonic anhydrase inhibitors, to aspirin, renal or hepatic impairment, corticosteroids, coumarin asthma and G6PD deficiency anticoagulants, sulphonylureas, methotrexate, phenytoin, valproic acid, probenecid, sulphinpyrazone Acetylsalicylic Acid 300 mg Soluble C Initial treatment of cardiovascular 150mg to be taken daily. Use in children Gastric haemorrhage, hypersensitivity, Gastric and duodenal ulcers, Acetazolamide, Dipyridamol : Renal disorders, G6PD deficiency, Tablet disorders such as angina pectoris and under 16 years old is not recommended thrombocytopenia,GI disturbances; haemorrhagic diathesis, hypersensitivity salicylate toxicity (vomiting, pregnancy, patients with flu, chicken pox myocardial infection and for the prolonged bleeding time, rhinitis, to aspirin or other NSAIDs, children under tachycardia, hyperpnea, mental or haemorrhagic fever. History of peptic prevention of cardiovascular events in urticaria and epigastric discomfort; 12 years old.Hypersensitivity (attacks of confusion) or acetazolamide ulcer or those prone to dyspepsia and patients at risk. Other such uses include angioedema, salicylism, tinnitus; asthma, angioedema, urticaria or toxicity (fatigue, lethargy, those with gastric mucosal lesion; the treatment and prevention of bronchospasm rhinitis); pregnancy (third trimester); somnolence, confusion, asthma or allergic disorders; dehydrated cerebrovascular disorders such as stroke patients with haemophilia or hyperchloremic metabolic acidosis). patients; uncontrolled hypertension; haemorrhagic disorders; gout; severe Alendronate : GI distress. Antacids, impaired renal or hepatic function; renal or hepatic impairment; lactation calcium. Alcohol, corticosteroids, elderly phenylbutazone and oxyphenbutazone may increase risk of GI ulceration. Aspirin increases phenytoin levels. May antagonize actions of uricosurics and spironolactone Acyclovir 200 mg Tablet A/KK i) Mucocutaneous Herpes Simplex i) ADULT: initially 400 mg 5 times daily Skin rashes; GI effects; fatigue Patients known to be hypersensitivity to Increased mean half-life & plasma Patients with pre-existing neurologic, infection in immunocompromised and for 7 - 14 days. CHILD less than 2 years: acyclovir concentration with probenecid renal, or hepatic impairment, dehydrated AIDS patients 200 mg 4 times daily, CHILD more than 2 patient, elderly and lactation ii) Primary and recurrent Varicella Zoster years: 400 mg 4 times daily infection in immunocompromised and ii), iii) and iv) ADULT: 200 - 400 mg 4 AIDS patients times daily. CHILD: less than 2 years, half iii) Severe Kaposi Varicella Eruption adult dose; more than 2 years, adult (Eczema herpeticum) dose iv) Severe primary HSV infections (eg. v) ADULT: 800 mg 5 times daily for 7 days Neonatal herpes, encephalitis, eczema vi) ADULT: 20 mg/kg (maximum: 800 mg) herpeticum, genital herpes, gingival four times daily for 5 days, CHILD 6 stomatitis, vaginal delivery with maternal years: 800 mg four times daily. CHILD vulva herpes) less than 2 years; 400mg 4 times daily, v) Severe and complicated varicella more than 2 years; 800mg 4 times daily infection (eg. Encephalitis, purpura fulminans) vi) Severe zoster infection in paediatrics (eg. Encephalitis, purpura fulminans, immunocompromised patients and facial, sacral and motor zoster) Acyclovir 800 mg Tablet A/KK i) Mucocutaneous Herpes Simplex i) ADULT: initially 400 mg 5 times daily for Skin rashes; GI effects; fatigue Patients known to be hypersensitivity to Increased mean half-life & plasma Patients with pre-existing neurologic, infection in immunocompromised and 7 - 14 days. CHILD less than 2 years: 200 acyclovir concentration with probenecid renal, or hepatic impairment, dehydrated AIDS patients ii) Primary and recurrent mg 4 times daily, CHILD more than 2 patient, elderly and lactation Varicella Zoster infection in years: 400 mg 4 times daily ii), iii) and iv) immunocompromised and AIDS patients ADULT: 200 - 400 mg 4 times daily. iii) Severe Kaposi Varicella Eruption CHILD: less than 2 years, half adult dose; (Eczema herpeticum) iv) Severe primary more than 2 years, adult dose v) ADULT: HSV infections (eg. Neonatal herpes, 800 mg 5 times daily for 7 days vi) encephalitis, eczema herpeticum, genital ADULT: 20 mg/kg (maximum: 800 mg) herpes, gingival stomatitis, vaginal four times daily for 5 days, CHILD 6 years: delivery with maternal vulva herpes) v) 800 mg four times daily. CHILD less than Severe and complicated varicella 2 years; 400mg 4 times daily, more than infection (eg. Encephalitis, purpura 2 years; 800mg 4 times daily fulminans) vi) Severe zoster infection in paediatrics (eg. Encephalitis, purpura fulminans, immunocompromised patients and facial, sacral and motor zoster) Agomelatine 25 mg Tablet A* Major depression The recommended dose is 25mg once Headache, dizziness, somnolence, History of previous hypersensitivity to CYP2C9 & CYP1A2 inhibitors (eg Use in people with dementia or impaired daily at bedtime, maybe increased to insomnia, migraine; anxiety; nausea, the active ingredient or any of the fluvoxamine, ciprofloxacin, liver function, renal impairment, mania 50mg once daily at bedtime. diarrhea, constipation, upper abdominal excipients. Hepatic impairment (i.e. propranolol, grepafloxacin, or hypomania. Increased risk of suicidal pain; hyperhidrosis; back pain; fatigue; cirrhosis or active liver disease). Taking enoxacin), oestrogenS tendencies, lactose intolerance. Perform increased ALAT &/or ASAT. potent CYP1A2 inhibitors (e.g. liver function tests periodically. May fluvoxamine, ciprofloxacin) impair ability to drive or operate machinery. Pregnancy & lactation, elderly, children. Albendazole 200 mg Tablet C+ i) Single or mixed infestations of i)Child 12-24months: 200mg as a single Gastrointestinal discomfort, dizziness, Patients with hypersensitivity to Concurrent use with Discontinue therapy if liver function test intestinal parasites dose headache, erythema multiforme, Stevens- albendazole or to the benzimidazole drug dexamethasone may result in an elevations are significant, retinal lesions, ii) Strongyloides infection ii) Adult & Child above 2 years: 400mg Johnson syndrome, agranulocytosis, class, pregnancy (avoid pregnancy for at increased risk of albendazole cerebral hypertensive episodes, as a single dose for 3 consecutive days; aplastic anemia, leukopenia, least one month following therapy) adverse effects. pregnancy, hepatic disease, retinal Child 12 - 24months: 200mg as a single pancytopenia, thrombocytopenia, lesions dose for
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