School of Pharmacy & Life Sciences
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School of Pharmacy & Life Sciences Research Portfolios 2017/2018 www.rgu.ac.uk/pals-ResEARCH 21/05/18- 027 Staff Listed TRANSLATIONAL RESEARCH WELCOME Theme lead Prof. Susan Duthie Dr. Gemma Barron Prof. Donald Cairns The School of Pharmacy and Life under two main themes; Translational Dr. Stuart Cruickshank ” Dr. Alberto Di Salvo Sciences is the largest school in Robert Research and Clinical Practice Research. Key Dr. Christine Edwards Gordon University (RGU) comprising areas within these themes include Analytical, Dr. Carlos Fernandez over 50 academic staff. Biological and Pharmaceutical Sciences, Dr. Marie Goua Dr. Graeme Kay Dietetics and Pharmaceutical Care. External In 2013, the School moved to modern, Dr. Rachel M. Knott grant income in excess of £3M was secured Prof. Paul Kong Thoo Lin purpose-build accommodation equipped with for the 2016-17 session from a variety of Dr Andrew Lamb world-class laboratory and support facilities. Prof. Linda A. Lawton sources including Research Councils, Scottish The School currently delivers undergraduate Dr. Lindsey Masson Government, Pharma industry and medical Dr. Kerr H. Matthews courses in Biomedical Sciences, Dietetics, charities. Collaborative projects, including Dr. Barbara McKenzie Forensic and Analytical Science, Nutrition, Prof. Wolfram Meier-Augenstein consultancies, are underway with Universities and Pharmacy along with postgraduate MSc Dr. Simon Officer and Research Centres in the Middle East, Dr. Bruce Petrie courses in Clinical Pharmacy Practice and Europe and the United States. Dr. Iain Rowe Instrumental Analytical Sciences. The School Dr. Colin Thompson also has a thriving postgraduate research Thank you for enquiring about research in Dr. Kyari Yates programme. There are currently more than the School of Pharmacy and Life Sciences at PRACTICE RESEARCH 40 doctoral students undertaking research in RGU. This introduction and welcome can Theme lead Prof. Derek Stewart the School and research degrees are offered only provide a brief overview of some of the Dr. Scott Cunningham Prof. Lesley Diack leading to the awards of Master of Research, research that is undertaken in the School. Dr. Myra Mackensie Doctor of Philosophy and the Doctorate of Please contact me, or any of the staff listed Dr. Katie MacLure Professional Practice. in this guide, to discuss your Dr. Noelle O’Driscoll Dr. Alison Strath research interests. Dr. Antonella Tonna To complement this portfolio of taught ” Dr. Anita Weidmann courses and postgraduate teaching, staff in Prof Donald Cairns Dr. Trudi MacIntosh the School conduct high-impact research Head of School, PALS. Dr. Katie Gibson Smith Page 1 TransLATIONAL RESEARCH Optimum health & wellbeing • diet & health • natural products • vascular health; • clinical dietetics • public health policy) Drug discovery, novel antimicrobial technologies and nanomaterials • natural products • drug & novel matrices design Environmental monitoring • sensors • clean technology • bioactive natural products & algal biotechnology Prof. Susan J. Duthie Email Transitional REsearch THEME LEADER [email protected] Associate Head of School (PALS) Telephone ResearchGate https://www.researchgate.net/profile/Susan_Duthie +44 (0) 1224 262815 Orcid Link http://orcid.org/0000-0002-7990-4437 RGU Link http://www.rgu.ac.uk/dmstaff/duthie-susan Research Interests Professor Duthie leads translational research models and in human case-control and intervention • Mechanisms of action of dietary within PALS. Her expertise centers around how studies. Moreover, she has investigated how gene- nutrients on human health and diet affects human health and particularly how nutrient interactions influence risk of malignancy, disease nutrition influence cell function and genomic specifically how polymorphisms in key folate stability. She has determined mechanistically metabolising enzymes influence genomic stability • Impact of plant compounds how specific phytochemicals (including and incidence of colorectal cancer in humans and including phytophenols, flavonoids, antioxidant vitamins and folic acid) has demonstrated how intervention with folic acid flavonoids and anthocyanins influence DNA damage and DNA repair. decreases DNA damage in healthy volunteers. With on human health; cancer and regards to CVD, she has shown how folate status vascular disease Recently, Prof. Duthie’s work has centred on how B alters protein expression and DNA methylation status vitamins influence human health and disease. She • Effect of micronutrients on in human aorta smooth muscle cells and that long- has established how folate status influences genomic cancer risk; differential effects term B vitamin deficiency increases atherosclerosis stability, global protein expression (proteomics) and of diet and supplements on by perturbing vascular lipid metabolism in transgenic genome-wide DNA methylation in vitro, in rodent malignant transformation ApoE mice. • Impact of B vitamins and antioxidants on cognitive 1. Herceg, Z., Ghantous, A., et al. (2018) Roadmap for investigating epigenome deregulation and environmental origins of cancer. International Journal of Cancer, 142(5) 874-882 function and dementia in the 2. Duthie, S.J., Duthie, G.G., et al (2017). Effect of increasing fruit and vegetable intake by dietary intervention on nutritional elderly biomarkers and attitudes to dietary change: a randomised trial. European Journal of Nutrition, 1-18 3. Duthie, S.J., Beattie, J.H., et al (2015). Nutritional B vitamin deficiency alters the expression of key proteins associated with vascular smooth muscle cell proliferation and migration in the aorta of atherosclerotic apolipoprotein E null mice. Genes and Nutri- • Impact of natural products from tion, 10(1) 1-11 underused ethnic foods on 4. Elliott, R.M., de Roos, B., Duthie, S.J.,et al (2014). Transcriptome analysis of peripheral blood mononuclear cells in human subjects following a 36 h fast provides evidence of effects on genes regulating inflammation, apoptosis and energy metabolism. human health Genes and Nutrition, 9(6) 1-11 Page 3 Email Dr. Gemma Barron [email protected] BSc (Hons), PhD, MRSC, MRSB Biomedical Science Telephone ResearchGate https://www.researchgate.net/profile/Gemma_Barron +44 (0) 1224 263154 Orcid Link http://orcid.org/0000-0003-2217-0900 RGU Link http://www.rgu.ac.uk/dmstaff/barron-gemma Dr Barron’s qualifications include a PhD in vitro (skin, brain, bladder and oesophageal cancer Medicinal Biochemistry (2010) and First Class cell lines). Research Interests BSc Honours degree in Forensic Science Gemma joined Robert Gordon University • Angiogenesis at the cellular/ (2006) both from Robert Gordon University, (2013-present) as a Research Fellow in the Institute of molecular level Aberdeen. Health and Wellbeing Research. In September 2015, She moved to the University of Dundee (2010-2013) she joined the School of Pharmacy and Life Sciences • Cancer therapeutics: DNA to undertake post doctoral research on a FP7-SME as a Part-Time Lecturer and Part-Time Research damage and repair funded project investigating the early detection of Fellow within the Centre for Obesity Research and cancer using photonic crystals lasers (EDOCAL) in Education (CORE). • Cancer diagnostics: Biomarkers in disease 1. Barron, P.J., Burgess, K., Cooper, K., Stewart, A.D. (2018). The effect of pitched and vertical ladder ergometer climbing on • Effect of natural products in cardiorepiratory and psychophysical variables. Applied Ergonomics, 66, 172-176 cancer 2. Barron, G.A., Goua, M., Wahle, K.W.J., Bermano, G. (2017). Circulating levels of angiogenesis-related growth factors in breast cancer: A study to profile proteins responsible for tubule formation. Oncology Reports, 38(3) 1886-1894 3. Barron, P.J., Burgess, K., Cooper, K., Stewart, A.D. (2017). The physiological effect of a ‘climb assist’ device on vertical ladder climbing. Ergonomics, 60(7) 1008-1013 4. Kopsida, M., Barron, G.A., Bermano, G., Kong Thoo Lin, P., Goua, M. (2016). Novel bisnaphthalimidopropyl (BNIPs) deriva- tives as anticancer compounds targeting DNA in human breast cancer cells. Organic and Biomolecular Chemistry, 14(41) 9780- 9789 5. Barron, G.A., Goua, M., Kuraoka, I., Bermano, G., Iwai, S., Kong Thoo Lin, P. (2015). Bisnaphthalimidopropyl diaminodicy- clohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. Chemico-Bio- logical Interactions, 242, 307-31 Page 4 Prof. Donald Cairns Email BSc (Hons), PhD, FRPharmS, C.Sci, C.Chem, FRSC. [email protected] Head of School (PALS). Telephone ResearchGate https://www.researchgate.net/profile/Donald_Cairns +44 (0) 1224 262501 Orcid Link http://orcid.org/0000-0001-7086-7441 RGU Link http://www.rgu.ac.uk/dmstaff/cairns-donald Professor Cairns leads the strategic planning, year spent in hospital pharmacy, returned to coordination, development and supervision Strathclyde to undertake a PhD on the synthesis and Research Interests of academic work at the School of Pharmacy properties of benzylimidazolines. • The design, synthesis and and Life Sciences. He is a member of the evaluation of novel prodrugs for Following a year as a post-doctoral research fellow, GPhC, the Royal Pharmaceutical Society, the the treatment of nephropathic Dr Cairns moved to Leicester Polytechnic (now Association of Pharmaceutical Scientists and in cystinosis De Montfort University) where he held a five-year 2008 was made a Fellow of the Royal Society lectureship in pharmacy. In 1992 he was appointed of Chemistry. He has served as a