Cat# Name Description D1 and D5 Receptors 1534 A 68930 hydrochloride Potent, selective D1-like agonist 0884 Dihydrexidine hydrochloride Selective D1-like agonist 0925 SCH 23390 hydrochloride Standard selective D1-like antagonist; also 5-HT2C and 5-HT1C agonist and Kir3 channel blocker 2299 SCH 39166 hydrobromide High affinity D1/D5 receptor antagonist 1447 SKF 81297 hydrobromide D1 agonist 2074 SKF 83959 hydrobromide D1-like partial agonist D2 Receptors 1003 L-741,626 High affinity D2 antagonist 1061 (-)-Quinpirole hydrochloride Selective D2-like agonist 5041 PAOPA Dopamine D2 receptor allosteric modulator 1810 Raclopride Potent, selective D2/D3 antagonist 3680 Ropinirole Selective D2-like agonist 2773 Sumanirole maleate D2-selective agonist D3 Receptors Dopamine 1847 Eticlopride hydrochloride Selective D2/D3 antagonist 1347 Nafadotride Highly potent, preferential D3 antagonist 1243 (+)-PD 128907 hydrochloride D3 agonist (D3 ≥ D2 > D4) 4174 Pramipexole dihydrochloride Selective D3 agonist 4207 SB 277011A dihydrochloride Selective D3 antagonist D4 Receptors 1002 L-745,870 trihydrochloride Highly selective D4 antagonist 2329 Ro 10-5824 dihydrochloride Selective D4 receptor partial agonist 1065 PD 168077 maleate High affinity, selective D4 agonist Dopamine Transporters 0421 GBR 12909 dihydrochloride Selective DA uptake inhibitor. Also σ ligand 1588 Indatraline hydrochloride Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake Non-selective Dopamine 2073 (R)-(-)-Apomorphine hydrochloride Dopamine agonist; non-subtype-selective 3788 L-DOPA Dopamine precursor 2460 Lazabemide hydrochloride Selective MAO-B inhibitor 4395 Moclobemide Reversible MAO-A inhibitor Monoamine Oxidase 4308 Rasagiline mesylate Selective, irreversible MAO-B inhibitor 0723 Tetrindole mesylate MAO-A inhibitor 4720 Entacapone Potent COMT inhibitor; blocks α-synuclein aggregation Catechol O-methyltransferase 0483 OR-486 Catechol O -methyltransferase inhibitor 4534 CZC 54252 hydrochloride Potent LRRK2 inhibitor; neuroprotective LRRK2 4629 GSK2578215A Potent, selective LRRK2 inhibitor; brain penetrant 4273 LRRK2-IN-1 Potent and selective LRRK2 inhibitor 1063 CGS 21680 hydrochloride A2A agonist 5147 Istradefylline Potent and selective adenosine A2A receptor antagonist Adenosine A2A Receptors 4334 PSB 0777 ammonium salt Potent adenosine A2A agonist 2463 SCH 442416 Very selective, high affinity A2A antagonist 2270 SCH 58261 Potent, highly selective A2A antagonist 0455 (S )-(-)-Carbidopa Aromatic L-amino acid decarboxylase inhibitor Decarboxylases 0584 L-(-)-α-Methyldopa Aromatic L-amino acid decarboxylase inhibitor GABAA Receptors 0131 (-)-Bicuculline methochloride Water-soluble GABAA antagonist 1088 CGP 54626 hydrochloride Potent, selective GABAB antagonist GABA Receptors 1248 CGP 55845 hydrochloride Potent, selective GABAB antagonist 0289 Muscimol Potent, GABAA,GABAA-ρ receptor agonist 0984 SCH 50911 Selective, competitive and orally active GABAB antagonist 1262 SR 95531 hydrobromide Selective, competitive GABAA receptor antagonist Cat# Name Description NMDA Receptors 0106 D-AP5 Potent, selective NMDA antagonist 0173 (RS) -CPP Potent NMDA antagonist 1409 CGP 39551 Potent, selective and competitive NMDA antagonist 0545 Ifenprodil hemitartrate Non-competitive NMDA antagonist. Also σ ligand 0924 (+)-MK 801 maleate Non-competitive NMDA antagonist; acts at ion channel site 1594 Ro 25-6981 maleate NR2B-selective NMDA antagonist AMPK Receptors 0254 (S)-AMPA Selective AMPA agonist 0713 Cyclothiazide AMPA selective desensitization inhibitor 2766 Naspm trihydrochloride Ca2+-permeable AMPA receptor antagonist 0373 NBQX Potent AMPA antagonist 5032 Talampanel Non-competitive AMPA/kainate antagonist mGlu Group I Receptors 0805 (S) -3,5-DHPG Selective group I mGlu agonist Glutamate Receptors 2921 MTEP hydrochloride Potent, selective mGlu5 antagonist mGlu Group II Receptors 4048 BINA Selective positive allosteric modulator of mGlu 2 1209 LY 341495 Highly potent, selective group II antagonist 2453 LY 379268 Highly selective group II mGlu agonist mGlu Group III Receptors 0103 L-AP4 Selective group III mGlu agonist 2963 MMPIP hydrochloride Potent, allosteric mGlu7-selective antagonist 4371 VU 0364439 Positive allosteric modulator at mGlu 4 Kainate Receptors 2728 ACET Potent antagonist of GluR5-containing kainate receptors 3620 Topiramate GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 0269 Domoic acid Potent, selective kainate agonist 2555 GYKI 53655 hydrochloride Kainate receptor antagonist; blocks GluK3 receptors 0903 SYM 2081 Highly selective kainate agonist 2079 UBP 302 Potent and selective kainate antagonist 5-HT1A Receptors 0529 8-Hydroxy-DPAT hydrobromide Selective 5-HT1A agonist 1253 (S)-WAY 100135 dihydrochloride Potent, selective 5-HT1A antagonist 4380 WAY 100635 maleate Potent, 5-HT1A silent antagonist. Also D4 agonist 5-HT1B Receptors 1477 GR 127935 hydrochloride Potent, selective 5-HT1B/1D antagonist 1242 SB 216641 hydrochloride Selective h5-HT1B antagonist 1221 SB 224289 hydrochloride Selective 5-HT1B antagonist 5-HT2A Receptors 0908 Ketanserin tartrate Selective 5-HT2A antagonist. Also antagonist at 5-HT 1D 4486 AT 1015 Long-acting 5-HT2A antagonist Serotonin Receptors 4470 EMD 281014 hydrochloride Selective 5-HT2A antagonist 4173 MDL 100907 Potent and selective 5-HT2A antagonist 2865 Risperidone 5-HT2A antagonist 2592 TCB-2 Potent, high affinity 5-HT2A agonist 5-HT2C Receptors 3041 CP 809101 hydrochloride Potent and selective 5-HT2C agonist 1007 N-Desmethylclozapine 5-HT2C antagonist 0941 MK 212 hydrochloride 5-HT2C agonist 1854 Ro 60-0175 fumarate Potent, selective 5-HT2C agonist 1050 RS 102221 hydrochloride Selective 5-HT2C antagonist 1801 WAY 161503 hydrochloride Potent, selective 5-HT2C agonist.