The editor of The Journal of Pharmacology and Experimental Therapeutics wishes to express appreciation to the following colleagues who acted as Guest Editors for Specific Fields in 1980:

Edmund G. Anderson Dora B. Goldstein Lewis Seiden Lewis Aronow Garrett J. Gross Parkhurst Shore Uoyd Beck John Harvey Roger Smith John A. Bevan Donald J. Jenden Solomon Snyder David A. Blake Louis Lemberger Ewart Swinyard Theodore M. Brody Roberto Levi David J. Tniggle Edward J. Cafruny Louis Levy Norman Weiner Leonard Cook Kafait U. Malik Theodore C. West William C. de Groat Perry Molinoff David P. Westfall Bahjat A. Faraj John C. McGiff Thomas Westfall Lawrence J. Fischer D. E. McMillan Dixon M. Woodbury Shri N. Gin David E. Potter Richard J. Wurtman Leon GoJdberg Arthur Raines Ben Zimmerman

Additionally, sincere thanks are due to 497 of our colleagues not on the Editorial Advisory Board who reviewed articles for the Journal in 1980.

872 874 INDEX

and withdrawal (rats), 666 (rats), 834 Bylund, D. B.: Interactions of Catecholamines (see also specific effects of mazindol and homo- cerebral cortex, enhancement neuroleptic metabolites with name) logs (rats), 745 of y-aminobutynic acid inhi- dopaminergic, alpha adre- content in brain, actions of xy- effects of naltrexone dose and bition by sodium valproate in nergic and muscarinic cholin- lamine on (rats), 834 history of naltrexone expo- (rats),445 ergic receptors, 81 effects on spinal sympathetic sure on food- and codeine- cholinergic nerves in arteries of reflexes (frogs), 170 maintained responding (cats, rabbits), 544 Ca, inhibition of isoproterenol exogenous, intracortical spread (monkeys), 105 depletion and restoration of responses in skeletal muscle (kittens, cats), 841 effects of naltrexone on narcotic synaptic plasticity by exoge- (mice), 271 hyperpolarization in superior discrimination (pigeons, nous catecholamines (kit- Cabbat, F. S., see Heikkila, R. E., cervical ganglia, comparison monkeys), 652 tens, cats), 841 745 of receptors mediating (rab- effects of thiamine deficiency differences between mazindol Caffeine, effect on cardiac san- bits),440 (rats), 537 and homologs on biochemical colemmal 5’-nucleotidase Catravas, J. D. and Gills, C. N.: intravenous self-administration and behavioral responses (rats), 489 Metabolism of [3H]ben.zoyl- of drugs during food depni- (rats), 745 Calcium phenylalanyl-alanyl-proline vation and satiation (rats), disposition of morphine in -induced contraction of aortic by pulmonary angiotensin 241 (rats), 181 strips, effects of calmodulin converting enzyme in vivo: pentobarbital-reinforced, role effects ofp-chloroamphetamine antagonists on (rabbits), 494 Effects of bradykinin SQ of pentobarbital drinking on locomotor activity and influx in aorta and mesenteric 14225 or acute hypoxia, 263 (monkeys), 114 serotonin leveLs (rats), 738 arteries, inhibition by flunar- Catravas, J. D., Lazo, J. S. and three-choice drug discrimina- effects of phencyclidine on izine of (rats), 510 Gillis, C. N.: Biochemical tion (rats), 254 turnover rate of acetylcholine Calcium antagonists, comparison markers of bleomycin toxic- Belinsky, S. A., see Reinke, L. A., in (rats), 733 on coronary blood flow in ity: Clearance of [‘4C]-5-hy- 863 measurement of imipramine myocardial ischemia (dogs), droxytryptamine and [3H}- Benzolamide, effect on sodium en- and desmethylimipramine in 20 norepinephnine by rabbit try to cerebrospinal fluid (rats), 461 Calmodulin, antagonists, effects lung in vivo, 524 (rats),51 potassium-induced release of on calcium-induced contrac- Catravas, J. D. and Waters, I. W.: [3H]Benzoyl-phenylalanyl-alanyl- dopamine and norepineph- tion of aortic strips (rabbits), Acute cocaine intoxication in proline, metabolism by pul- rine from, effects of catechol- 494 the conscious dog: Studies on monary angiotensin convert- amine uptake inhibitors Canrenone, effect on Na-K- the mechanism of lethality, ing enzyme in vivo, effects of (rats), 727 adenosine triphosphatase, in- 350 bradykinin, SQ 14225 or striatum, effects of amphet- teraction with ouabain Ceftizoxime, renal excretion and acute hypoxia (rabbits, dogs), amine on dopamine synthesis (guinea pigs), 784 distribution (rats), 209 263 in (rats), 686 Captopril, effect on nonenzymatic Cells, fat, perfused, growth hor- Berkowitz, A. L., see Patrick, R. whole1 monoamines, effects of methionine enkephalin mac- mone stimulation of lipolysis L., 686 reserpine (rats), 357 tivation in ileum (guinea and cyclic AMP in (rats), 15 Biotransformation, of methylmer- Branch, R. A., see James, R., 127 pigs), 750 Cerebrospinal fluid, sodium entry curic chloride, influence of Breese, G. R., see Lundberg, D. Caputy, A. J., Kim, Y. I. and to, effect of carbonic anhy- chelating agents (rats), 500 B., 215 Sanders, D. B.: The neuro- chase inhibitors and other Bircher, J., see Zysset, T., 198 Brink, C., Duncan, P. G. and muscular blocking effects of drugs (rats), 51 Bittar, E. E., see Helmer, P., 248 Douglas, J. S.: The response therapeutic concentrations of Chelating agents, influence on dis- Blake, D. A., see Spielberg, S. P., and sensitivity to histamine various antibiotics on normal tribution and biotransforma- 386 of respiratory tissues from rat skeletal muscle: A quan- tion of methylmercuric chlo- Blass, J. P., see Barclay, L. L., 537 normal and ovalbumin-sensi- titative comparison, 369 ride (rats), 500 Bleomycin, effect on pulmonary tized guinea pigs: Effects of Carbamazepine to carbamaze- Cheney, D. L., see Murray, T. F., amine uptake (rabbits), 524 cyclooxygenase and lipoxy- pine-10,11-epoxide pathway, 733 Blood flow genase inhibition, 592 induction effect of phenobar- Cheng, H. C., Gleason, E. M., Na- coronary, in myocardial isch- Brody, T. M., see Kim, D.-H., 559 bital on (monkeys), 555 than, B. A., Lachmann, P. J. emia, comparison of calcium Brody, T. M., see Temma, K., 708 Carbendilhin, inactivation of to- and Woodward, J. K.: Effects antagonists (dogs), 20 Brody, T. M., see Yamamoto, S., bramycin, gentamicin, netil- of clonidine on gastric acid renal, effects of lergotrile 701 micin and amikacin (man), secretion in the rat, 121 (dogs), 660 Bromobenzene, effect on drug 345 Cheng, K.-C., Lambert, J. J., Hen- Blood pressure metabolism within liver lob- Carbocromene, effects on myocar- derson, E. G., Smiowitz, H. effects of lergotrile (dogs), 660 ule (rats), 127 dial oxygen consumption in and Epstein, P. M.: Postsyn- effects of prazosin (rats), 397 2-Bromo-D-lysergic acid, diethyl- isolated hearts (dogs), 306 aptic inhibition of neuromus- increase, effects of interaction amide bitartrate (BOL) dual Carbon tetrachloride, effect on cular transmission by trifluo- between angiotensin and actions on dorsal root poten- drug metabolism within liver perazine, 44 opioid peptides (rats), 619 tials evoked by stimulation of lobule (rats), 127 Chikharev, V. N., see Gilmour, R. Bohr, D. F., see Webb, R. C., 26 raphe nuclei (cats), 99 Carbonic anhydrase inhibitors, ef- G., Jr., 390 Bone, resorption, parathyroid Bross, D. S., see Spielberg, S. P., fect on sodium entry to cere- Chinn, C., see Larson, A. A., 99 hormone-stimulated, inhibi- 386 brospinal fluid (rats), 51 Chiriquitoxin, new tool for tion by ouabain (mice), 586 $-Bungarotoxin, cholinergic Carroll, M. E., France, C. P. and mapping ionic channels Borow, K. M., Spann, J. F. and blocking actions of (guinea Meisch, R. A.: Intravenous (frogs), 416 Coulson, R. L.: The direct pigs, rabbits, rats, mice), 505 self-administration of etoni- p-Chloroamphetamine, effects on myocardial energetic re- Bupropion, radioimmunoassay tazene, cocaine and phency- locomotor activity and sero- sponse to nitroglycerine in and pharmacokinetic profile clidine in rats during food tonin levels (rats), 738 the rabbit heart, 566 of (dogs, rabbits, man, rats, deprivation and satiation, 241 p-Chloromercuribenzyoate, iso- Bradykinin, effects on metabo- mice), 602 Casu, M. and Gale, K.: Differen- lated inotropic action in iso- lism of [3H}benzoyl-phenyla- Butcher, L. L., see Dudley, M. W., tial effects of y-aminobutyric lated heart, influence of lanyl-alanyl-proline by pul- 834 acid (GABA)-elevating membrane stabilizing agents monary angiotensin convert- Butz, R. F., Schroeder, D. H., agents on the neuroleptic-in- (guinea pigs), 768 ing enzyme in vivo (rabbits, Welch, R M., Mehta, N. B., duced activation of stniatal p-Chloro-N-methylanilane de- dogs), 263 Phillips, A. P. and Findlay, J. tyrosine-hydroxylase: Evi- methylase, activity in liver Brain W. A.: Radioimmunoassay dence that di-n-propylace- and fetal tissues (man, catecholamine content and up- and pharmacokinetic proffle tate augments GABAergic chicks), 572 take, action of xylamine of bupropion in the dog, 602 neurotransmission, 177 Chlorpromazine INDEX 875

comparison of in vitro potency of aprindine on (frogs), 390 cats), 26 fects of amphetamine (rats), at dopaminergic, alpha ad- Contraction, calcium-induced, of Dieu, D., see Godfraind, T., 510 686 renergic and muscarinic cho- aortic strips, effects of cal- Digitalis, toxicity, effect of can- Douglas, J. S., see Brink, C., 592 linergic receptor binding sites modulin antagonists (nab- renone (guinea pigs), 784 Doyle, A. S., see Vogh, B. P., 51 (sheep, rats), 81 bits),494 Digoxin, cardiac sensitivity, ef- Dubocovich, M. L., see Mas- pretreatment, effects on co- Cooper, T. B., see Jason, K. M., fects of quinidine (guinea singham, R., 467 caine lethality (dogs), 350 461 pigs, rats), 559 Duckles, S. P.: Evidence for a Cho, A. K., see Dudley, M. W., Copper, serum concentrations Dihydromorphine, transport functional cholinergic inner- 834 and seizures, influence of D- mechanisms in alimentary vation of cerebral arteries, Choline, high affinity uptake, in penicillamine (baboons), 138 epithelia (rats), 285 544 cerebral arteries (cats, nab- Coulson, R. L., see Borow, K. M., Dilation, coronary, effects of tn- Dudley, M. W., Butcher, L. L., bits), 544 566 mazosin (dogs), 333 Kammerer, R. C. and Cho, A. Chromatography Cyclic AMP 2,3-Dimercaptopropane- 1 -sulfo- K. The actions of xylamine gas-liquid, to measure levels of in perifused fat cells, growth nate, influence on distribu- on central noradrenergic neu- morphine in plasma and hormone stimulation of tion and biotransformation of rons, 834 brain (rats), 181 (rats), 15 methylmercuric chloride Dun, N. J. and Karczmar, A. G.: high-performance liquid, and levels, in isolated cardiac prep- (rats), 500 Evidence for a presynaptic radioimmunoassay, determi- arations, effects of glucagon Dimercaptosuccinic, influence on inhibitory action of 5-hy- nation of fluphenazine, re- (rats, guinea pigs), 798 distribution and biotransfor- droxytryptamine in a mam- lated phenothiazine drugs Cyclic AMP phosphodieterase, mation of methylmercuric malian sympathetic ganglion, and metabolites (rabbits, inhibitors, effect on cardiac chloride (rats), 500 714 man), 36 sarcolemmal 5’-nucleotidase Diphenhydramine, effect on ino- Duncan, P. G., see Brink, C., 592 Churchill, P., see Hatfield, M., 406 (rats), 489 tropic action of p-chloromer- Dustman, R. E., see Snyder, E. Ciguatoxin, actions in vas defer- Cyclazocine, discrimination (rats), cunibenzoate in isolated heart W.,299 ens (guinea pigs), 475 254 (guinea pigs), 708 Dyphylline, elimination in ure- Clearance Cyclooxygenase, inhibition, ef- Dipyridamole, effect on cardiac mia, pharmacokinetics of drug, effect of obesity (man), fects on response and sensi- sarcolemmal 5’-nucleotidase (man), 340 681 tivity to histamine of respi- (rats), 489 of [‘4C]-5-hydroxytryptamine ratory tissues (guinea pigs), Disposition, of morphine in brain Edema, paw, carrageenan-in- and [‘H]norepinephrine by 592 (rats), 181 duced influence of dietary lung after bleomycin (rab- Cytotoxicity, of anticonvulsants, Disobutamide, effects on electro- protein deficiency on sup- bits), 524 role of arene oxides in (man, physiologic properties of car- pressant activity of anti-in- renal, of ceftizoxime (rats), 209 mice), 386 diac Purkinje fibers and pap- flammatory agents in (rats), Clomethiazole, effect of ethanol illary muscle (dogs), 549 776 on first-pass elimination of Dangman, K. H. and Hoffman, B. Distribution Eells, J. T., Makar, A. B., Noker, (rabbits), 198 F.: In vivo and in vitro an- and renal excretion of ceftizox- P. E. and Tephly, T. R.: Clonidine tiarrhythmic and arrhyth- ime (rats), 209 Methanol poisoning and for- effects on gastric acid secretion mogenic effects of N-acetyl drug, effect of obesity (man), mate oxidation in nitrous ox- (rats), 121 procainamide, 851 681 ide-treated rats, 57 effect on growth hormone se- Deamino-8 D-arglrnne vasopres- of methylmercuric chloride, in- Electrolytes, in urine, central ef- cretion (rats), 152 sin, dose-dependent stimula- fluence of chelating agents fects of morphine, levor- Cocaine tion of renal prostaglandin (rats), 500 phanol, methadone and en- effect on potassium-induced synthesis by (rats), 87 Dita, effect on potassium-induced dorphins (rats), 579 release of dopamine and nor- Deen, K., see Summy-Long, J. Y., release of dopamine and nor- Electrophysiologic properties, of epinephrine from brain 619, 630 epinephrine from brain cardiac Purkinje fibers and (rats), 727 Deficiency, thiamine, impairment (rats), 727 papillary muscle, effects of intravenous self-administration of behavior and acetylcholine Divoll, M., see Abernethy, D. R., disobutamide (dogs), 549 during food deprivation and metabolism in (rats), 537 681 Electrophysiological effects, of N- satiation (rats), 241 Delaage, M. A., see Puizillout, J. Dohrmann, M. L., Harrell, F. E., acetyl procainamide in car- poisoning (dogs), 350 J., 791 Jr. and Strauss, H. C.: The diac tissues (dogs), 851 Codeine Dembiec, D. and Cohen, G.: effects of disobutamide on Elimination responding maintained by, ef- Potassium-induced release of electrophysiologic properties of dyphylline in uremia, phar- fects of naltrexone dose and [3H]catecholamine from of canine cardiac Purkinje fi- macokinetics (man), 340 history of naltrexone expo- brain: Effects of pre-exposure bers and papillary muscle, first-pass, of clomethiazole, ef- sure on (monkeys), 105 to catecholamine uptake in- 549 fect of ethanol (rabbits), 198 transport mechanisms in ali- hibitors, 727 L-Dopa, striatal dopamine forma- f3-Endorphin mentary epithelia (rats), 285 Desmethylimipramine, effect on tion from (rats), 189 central effects on urine volume Cohen, G., see Dembiec, D., 727 potassium-induced release of Dopamine and electrolytes (rats), 579 Colburn, W. A., see Wurzburger, dopamine and norepineph- agonists and antagonists, influ- inhibition of central actions of R. J., 757 rime from brain (rats), 727 ence on locomotor activity angiotensin by (rats), 619 Colchine, -induced supersensitiv- Desmond, P., see James, R., 127 after opioid receptor agonists Enkephalin-analog, stimulation of ity in vas deferens, role of Dhalla, N. S., see Heyliger, C. E., (rats), 451 pulmonary J receptors by changes in adrenergic nerves 489 brain, effects of mazindol and (rats), 228 for development of (rats), 516 Diabetes, hereditary, dose-depen- homologs (rats), 745 Enkephalins Cole, A. E. and Shinnick-Gal- dent stimulation of renal formation in stniatum after L- Leu5 and Met5, inhibition of lagher, P.: Comparison of the prostaglandin synthesis by dopa (rats), 189 central actions of angiotensin receptors mediating the cat- deamino-8-D-arginine vase- in brain and small intestine, ef- by (rats), 619 echolamine hyperpolaniza- pressin (rats), 87 fects of reserpine (rats), 357 met, nonenzymatic inactivation tion and slow inhibitory post- Diazepam receptor, presynaptic, stimula- in ileum, effect of captopril synaptic potential in sympa- effect of obesity on distribution tion in cardiovascular actions and ascorbic acid on (guinea thetic ganglia, 440 and clearance (man), 681 of lergotrile (dogs), 660 pigs), 750 Colon, nicotine action on (rats), pretreatment, effects on co- release from brain induced by Enzymes, y-glutamyl cycle, in fe- 828 caine lethality (dogs), 350 potassium, effects of cate- tel liver (man), 697 Cone, E. J., see Shannon, H. E., Dibutyryl-cyclic AMP, relaxation cholamine uptake inhibitors Epilepsy 379 of vascular smooth muscle by (rats), 727 influence of D-penicillamine on Contractile force, in atria, effect (rats, baboons, dogs, pigs, synthesis in brain striatum, ef- seizure activity and trace INDEX 877

turn after L-dopa administra- Serotonin) 326 Keil, L. C., see Summy-Long, J. tion, 189 inhibition of acetylcholine Itakura, T. see Kasamatsu, T., 841 619, 630 Heikkila, R. E., Cabbat, F. S., release in sympathetic gan- Iwamoto, E. T.: Locomotor activ- Kelly, M., see Gross, S. H., 271 Manzino, L., Babington, R. glion by (rabbits), 714 ity and antinociception after Kidney G. and Houlihan, W. J.: Un- [‘4C]-5-Hydroxytryptamine, clear- putative mu, kappa and clearance of ceftizoxime (rats), expected differences between ance by lung after bleomycin sigma opioid receptor ago- 209 mazindol and its homologs on (rabbits), 524 nists in the rat: Influence of function, effects of prostaglan- biochemical and behavioral 6-Hydroxytryptamine, endoge- dopaminergic agonists and din Fk (dogs), 674 responses, 745 nous, intracortical spread antagonists, 451 prostaglandin synthesis, dose- Helmer, P., Rusy, B. and Bittar, (kittens, cats), 841 Iwasa, J., see Masutani, T., 812 dependent stimulation by E. E.: Sensitivity to halo- 5-Hydroxytryptophan, effect on deamino-8-D-arginine vase- thane of the sodium efflux in growth hormone secretion Jackson, M. J.: Transport mech- pressin (rat.s), 87 single barnacle muscle fibers, (rats), 152 anisms for narcotics and nan- vascular and tubular, effects of 248 Hypertension, tolerance to pra- cotic antagonists in alimen- vanadate (rats), 406 Henderson, E. G., see Cheng, K.- zocin in, involvement of tary epithelia, 285 Killam, E. K., see Alley, M. C., C., 44 renin-angiotensin system James, H., Desmond, P., K#{252}pfer, 138 Henningfield, J. E., see Meisch, R. (rats), 397 A., Schenker, S. and Branch, Killian, A. K., Schuster, C. R. and A., 114 Hypersensitivity reactions, in vi- H. A.: The differential locali- Wainer, B. H.: Effect of anti- Herling, S.: Effects of naltrexone tro, cardiac, thromboxane zation of various drug metab- morphine antibodies on an in dose and history of naltrex- and prostacyclin release dur- olizing systems within the rat vitro correlate of antagonist- one exposure on food- and ing (guinea pigs), 157 liver lobule as determined by precipitated opiate absti- cocaine-maintained respond- Hypoxia, acute, effects on metab- the hepatotoxins allyl alco- nence, 820 ing in rhesus monkeys, 105 olism of [3H]benzoyl-pheny- hol, carbon tetrachloride and Kim, D.-H., Akera, T. and Brody, Herling, S., see Valentino, R. J., lalanyl-alanyl-proline by pul- bromobenzene, 127 T. M.: Effects of quinidine on 652 monary angiotensin convert- Jason, K. M., Cooper, T. B. and the cardiac-glycoside sensi- Heyliger, C. E., Panagia, V. and ing enzyme in vivo (rabbits, Friedman, E.: Prenatal expo- tivity of guinea-pig and rat Dhalla, N. S.: Effect of cyclic dogs), 263 sure to imipramine alters heart, 559 AMP phosphodiesterase in- early behavioral develop- Kim, D.-H., see Yamamoto, S., hibitors on cardiac sarcolem- Ileum ment and beta adrenergic re- 701 ma! 5’-nucleotidase, 489 effect of captopril and ascorbic ceptors in rats, 461 Kim, Y. I., see Caputy, A. J., 369 Hidaka, H., see Kanamori, M., 494 acid on nonenzymatic methi- Jobe, P. C., see Stewart, J. J., 357 Kinetics Hingston, S. J., see La Morte, W. onine enkephalin inactiva- Jolly, S. R., Hardman, H. F. and of reaction top-chloro-N-meth- W., 638 tion in (guinea pigs), 750 Gross, G. J.: Comparison of ylaniine demethylase in liver Histamine isolated, effect of antimorphine two dihydropynidine calcium and fetal tissues (man, H- and H2-receptors in gall- antibodies on antagonist-pre- antagonists on coronary col- chicks), 572 bladder, pH-dependent activ- cipitated contracture in lateral blood flow in acute plasma, of phenylethanolamine ity (guinea pigs), 638 (guinea pigs), 820 myocardial ischemia, 20 and N-methyl phenyletha- in vitro release from basophils, Imipramine, prenatal exposure, Jonsson, G., see Kasamatsu, T., nolamine (dogs), 379 inhibition by zinc (man), 292 effect on early behavioral de- 841 Kliner, D. J., see Meisch, R. A., response and sensitivity of res- velopment and beta adrener- Jurevichus, J. A., see Gilmour, R. 114 piratory tissues to, effects of gic receptors (rats), 461 G., Jr., 390 Kondo, H., see Temma, K., 708 cyclooxygenase and lipoxy- Inotropic action Krieger, A. J., see Sapru, H. N., genase inhibition (guinea of p-chloromercuribenzoate in Kammerer, R. C., see Dudley, M. 228 pigs), 592 isolated heart, influence of W., 834 Krieger, N. S. and Tashjian, A. Hoffman, B. F., see Dangman, K. membrane stabilizing agent Kanamori, M., Naka, M., Asano, H., Jr.: Inhibition by ouabain H., 851 (guinea pigs), 708 M. and Hidaka, H.: Effects of of parathyroid hormone- Holtzman, S. G., see White, J. M., ofisoproterenol in heart (mice), N (6-aminohexyl) - 5 - chloro- stimulated bone resorption, 254 314 1 - aphthalenesulfonamide 586 Horwitz, J., see Lucot, J. B., 738 of ouabain in heart (guinea and other calmodulin antag- Krishnaswamy, K., see Rollins, Houlihan, W. J., see Heikkila, R. pigs), 701 onists (calmodulin interact- D., 697 E., 745 Intestine ing agents) on calcium-in- Kuhn, C. M. and Schanberg, S. Huidobro, F., see Huidobro-Toro, formation of 1-thiocarbamoyl- duced contraction of rabbit M.: Maturation of central J. P., 579 2-imidazolidinone from niri- aortic strips, 494 nervous system control of Huidobro-Toro, J. P. and Hui- dazole in (mice), 363 Kao, C. Y., Yeoh, P. N., Goldfin- growth hormone secretion in dobro, F.: Central effects of small, monoamines, effects of ger, M. D., Fuhrman, F. A. rats, 152 morphine, levorphanol, (-)- reserpine (rats), 357 and Mosher, H. S.: Chiniqui- K#{252}pfer,A., see James, R., 127 methadone and the opioid- small, transit, effects of reser- toxin, a new tool for mapping Kuramatsu, I., see Miura, A., 505 like peptides /3-endorphin pine on (rats), 357 ionic channels, 416 and D-alanine2-methiOfline Inturnisi, C. E., see Ling, G. S. F., Kaplan, H. R., see Smith, R. D., Lachmann, P. J., see Cheng, H. enkephalinamide on urine 147 397 C., 121 volume outflow and electro- Ionic channels, mapping, by chi- Karasawa, T., see Masuda, Y., 805 Lambert, J. J., see Cheng, K.-C., lytes, 579 niquitoxin (frogs), 416 Karczmar, A. G., see Dun, N. J., 44 Hyaluronidase, effect on resist- Isoproterenol 714 La Monte, W. W., Hingston, S. J. ance and transport after cor- comparison with glucagon on Karras, P. J. and North, R. A.: and Wise, W. E.: pH-depen- onary flow reduction (dogs), cyclic AMP levels in isolated Acute and chronic effects of dent activity of H1- and H- 62 cardiac preparations (rats, opiates on single neurons of histamine receptors in Hydralozine, effect in arteries and guinea pigs), 798 the myenteric plexis, 70 guinea-pig gallbladder, 638 veins (man), 204 inotropic action in heart (mice), Kasamatsu, T., Itakura, T. and Langer, S. Z., see Massingham, R., 6-Hydroxydopamine, effects on 314 Jonsson, G.: Intracortical 467 disposition of norepinephrine relaxation of vascular smooth spread of exogenous cate- Larson, A. A., Chinn, C., Proudflt, in aorta (rabbits), 162 muscle by (rats, baboons, cholamines: Effective con- H. K. and Anderson, E. G.: 5-Hydroxyindoleacetic acid, ra- dogs, pigs, cats), 26 centration for modifying con- Dual actions of lysergic acid dioimmunoassay, use of iodi- responses in skeletal muscle, tical plasticity, 841 diethylamide tartrate (LSD), nated derivative (rabbits), Ca inhibition of (mice), 271 Kasuya, Y., see Saito, A., 516 2-bromo-D-lysergic acid di- 791 -stimulated phosphorylase a Kauffman, F. C., see Reinke, L. ethylamide bitartrate (BOL) 5-Hydroxytryptamine (see also formation in heart (mice), A., 863 and methysergide on dorsal 878 INDEX

root potentials evoked by trophenol in (rats), 863 Lichtenstein, L. M.: Modula- 537 stimulation of raphe nuclei, Locomotor activity tion of histamine release from arachidonic acid, relation to 99 after opioid receptor agonists, human basophils in vitro by histamine-induced contrac- Larsson, A., see Rollins, D., 697 influence of dopaminergic ag- physiological concentrations tion in airway muscle (guinea Lazo, J. S., see Catravas, C. D., onists and antagonists (rats), of zinc, 292 pigs), 592 524 451 Mason, G. A., see Osbahr, A. J. drug, in obesity (man), 681 Lee, C-S. C., Wang, L H., Ma- effects ofp-chloroamphetamine III, 645 drug, within liver lobule, effects jeske, B. L. and Marbury, T. (rats), 738 Massingham, R., Dubocovich, M. of hepatoxins (rats), 127 C.: Pharmacokinetics of dy- Lokhandwala, M. F., see Barrett, L, Shepperson N. B. and ethanol, after chronic ethanol phylline elimination by RJ.,660 Langer, S. Z.: In vivo selectiv- consumption, role of alcohol uremic patients, 340 Long, K. J., see Sengupta, K., 15 ity of prazosin but not of dehydrogenase (rats), 133 Lee, C.-Y., see Miura, A., 505 Lucot, J. B., Horwitz, J. and Sei- WB41O1 for postsynaptic al- of [3H]benzoyl-phenylalanyl- Leff, A. R. and Munoz, N. M.: dent, L. S.: The effects of p- p/ia-i adrenoceptors, 467 alanyl-proline by pulmonary Evidence for two subtypes of chloroamphetamine admin- Masuda, Y., Utsui, Y., Shiraishi, angiotensin converting en- alpha adrenergic receptors in istration on locomotor activ- Y., Karasawa, T., Yoshida, K. zyme in vivo, effects of brady- canine airway smooth mus- ity and serotonin in neonatal and Shimizu, M.: Evidence kinin, SQ 14225 or acute hy- cle, 530 and adult rats, 738 for a synergistic interaction poxia (rabbits, dogs), 263 Lergotrile, cardiovascular actions, Lundberg, D. B., Breese, G. R. between phenytoin and phe- of niridazole in intestine (mice), stimulation of presynaptic and Mueller, R. A.: Amino- nobarbital in experimental 363 dopamine receptors in (dogs), phylline may stimulate res- animals, 805 Metabolites 660 piration in rats by activation Masutani, T., Seyama, I., Nara- neuroleptic, interactions with Levi, R., see Allan, G., 157 of dopaminergic receptors, hashi, T. and Iwasa, J.: Struc- dopaminergic, alpha adre- Levin, J. A. and Wilson, S. E.: The 215 ture-activity relationship for nergic and muscaninic cholin- effects of 6-hydroxydopa- Lung grayanotoxin derivatives in ergic receptors (sheep, rats), mine on the disposition of angiotensin-converting enzyme,, frog skeletal muscle, 812 81 norepinephrine in the rabbit effects of bradykinin, SQ Mather, L. E., Gourlay, G. K., phenothiazine, determination aorta, 162 14225 or acute hypoxia on Parkin, K. S. and Roberts, J. by combined high-perform-

Levorphanol, central effects on metabolism of [3H]benzoyl- ..‘ G.: Pharmacodynamics of ance liquid chromatography urine volume and electrolytes phenylalanyl-alanyl-proline minaxolone, a new steroidal and radioimmunoassay (rab- (rats), 579 in vivo by (rabbits, dogs), 263 anesthetic, 481 bits, man), 36 Levy, R. H., see Patel, I. H., 555 effect of bleomycin on amine Matsuzaki, S., Gordon, E. and Lie- Methadone Lichtenstein, L. M., see Marone, uptake by (rabbits), 524 ber, C. S.: Increased alcohol interaction with theophylline, G., 292 sensory receptors, stimulation dehydrogenase independent effect upon respiration and Lieber, C. S., see Matsuzaki, S., by enkephalin-analog (rats), ethanol oxidation at high ventilation (dogs), 278 133 228 ethanol concentrations in iso- radioimmunoassay and phar- Lieber, C. S., see Vittek, J., 411 Luttinger, D., see Osbahar, A. J. lated rat hepatocytes: The ef- macokinetics (rats), 147 Ling, G., see Nozaki, M., 666 III, 645 fect of chronic ethanol feed- transport mechanisms in ali- TAng, G. S. F., Umans, J. G. and Lymphocytes, cytotoxicity in, an- ing, 133 mentary epithelia (rats), 285 Inturrisi, C. E.: Methadone: ticonvulsant role of arene ox- Mazindol (-)-Methadone, central effects on Radioimmunoassay and ides (man, mice), 386 and homologs, different effects urine volume and electrolytes pharmacokinetics in the rat, Lysergic acid diethylamide tar- on biochemical and behav- (rats), 579 147 trate (LSD), dual actions, ioral responses (rats), 745 Methanol, poisoning in nitrous IApe, S. and Moulds, R. F. W.: In on dorsal root potentials effect on potassium-induced oxide treatment (rats), 57 vitro differences between hu- evoked by stimulation of release of dopamine and nor- Methazolamide, effect on sodium man arteries and veins in raphe nuclei (cats), 99 epinephnine from brain entry to cerebrospinal fluid their responses to hydrala- (rats), 727 (rats), 51 zine, 204 Macho, P. and Vatner, S. F.: Ef- McEnlane, B., see Tam, Y. K., 764 Methylmercunic chloride, distri- Lipolysis, in perfused fat cells, fects and mechanism of ac- McNeill, J. H., see MacLeod, K. bution and biotransforma- growth hormone stimulation tion of tnimazosin on coro- M., 798 tion, influence of chelating of (rats), 15 nary and left ventricular dy- Mecillinam, inactivation of tobra- agents on (rats), 500 Lipoxygenase, inhibition, effects namics in conscious dogs, 333 mycin, gentamicin, netilmicin N-Methyl phenylethanolamine, on response and sensitivity to MacLeod, K. M., Rodgers, R L and amikacin (man), 345 physiologic effects and histamine of respiratory tin- and McNeil!, J. H.: Charac- Medzihradsky, F., see Valentino, plasma kinetics of (dogs), 379 sues (guinea pigs), 592 terization of glucagon-in- H. J., 652 Methylxanthines (see specific Liver duced changes in rate, con- Meht.a, N. B., see Butz, R. F., 602 drug) p-chloro-N-methylanilane de- tractiity and cyclic AMP Meiach, R. A., see Carroll, M. E., Methysergide, dual actions on methylase activity in (man, levels in isolated cardiac 241 dorsal root potentials evoked chicks), 572 preparations of the rat and Meisch, H. A., Kliner, D. J. and by stimulation of raphe nu- effect of ethanol on testoster- guinea pig, 798 Henningfield, J. E.: Pento- clei (cats), 99 one-5a-reductase in (rats), Maes, R. A. A., see Plomp, G. J. barbital drinking by rhesus Metoclopramide, dose-dependent 411 J., 181 monkeys: Establishment and pharmacokinetics of (rats), ethanol oxidation at high Majeske, B. L, see Lee, C.-S. C., maintenance of pentobarbi- 764 ethanol concentrations, role 340 tel-reinforced behavior, 114 Mezlocillin, inactivation of tobra- of alcohol dehydrogenase Makar, A. B., see Bells, J. T., 57 Melamed, E., see Hefti, F., 189 mycin, gentamicin, retilmicin (rats), 133 Malcolm, R. D. and Alkana, R L: Mellits, E. D., see Spielberg, S. P., and amikacin (man), 345 fetal, glutathione and y-gluta- Temperature dependence of 386 Miller, D. D., see Fuder, H, 1 myl cycle enzymes in (man), ethanol depression in mice, Membrane currents, in peripheral Miller, R. L, see Wurzburger, R. 697 770 nerve, effects ofgallamine tri- J., 757 influence of dietary protein de- Manzino, L, see Heikkila, R E., ethiodide (rats, frogs), 719 Minaxolone, new steroidal anes- ficiency on lysosome stabiliz- 745 Mephenytoin, cytotoxicity, role of thetic, pharmacodynamics of ing activity of anti-inflam- Marbury, T. C., see Lee, C.-S. C., arene oxides (man, mice), 386 (sheep), 481 matory agents in (rats), 776 340 Merz, H., see Valentino, R. J., 652 Miura, A., Muramatsu, I., Fuji- lobule, drug metabolism, effects Marcum, E. A., see Wurzburger, Metabolism wara, M., Hayashi, K. and of hepatoxins (rats), 127 R. J., 757 acetylcholine, in thiamine defi- Lee, C.-Y., Species and re- perfused, conjugation of p-ni- Marone, G., Findlay, S. R and ciency, impairment (rats), gional differences in cholin- 880 INDEX

Oxidation arene oxides (man, mice), 386 ical activity, 181 ing an iodinated derivative, formate, in nitrous oxide treat- Phencyclidine Poisoning 791 ment (rats), 57 and pentobarbital, effects on cocaine (dogs), 350 Purkinje fibers ethanol, at high ethanol con- fixed-interval performance methanol, in nitrous oxide cardiac, effects of disobutamide centrations in liver, role of (monkeys), 611 treatment (rats), 57 on electrophysiologic prop- alcohol dehydrogenase (rats), effect on turnover rate of ace- Potassium -induced release of do- erties of (dogs), 549 133 tylcholine in brain (rats), 733 pamine and norepinephrine isolated, effects ofN-acetyl pro- Oxygen, myocardial consumption, intravenous self-administration from brain, effects of cate- cainamide (dogs), 851 effects of carbocromene during flood deprivation and cholamine uptake inhibitors (dog), 306 satiation (rats), 241 (rats), 727 Quinidine, effects on cardiac gly- Phenobarbital Potassium channel, blockage by coside sensitivity (guinea Palatini, P., see Finotti, P., 784 cytotoxicity, role of arene ox- chiniquitoxin (frogs), 416 pigs, rats), 559 Panagia, V., see Heyliger, C. E., ides (man, mice), 386 Potential 489 effect on inotropic action of p- action, in skeletal muscle, effect Radioimmunoassay Pancuronium, pretreatment, ef- chloromercuribenzoate in of grayanotoxin (frogs), 8i2 and high-performance liquid fects on cocaine lethality isolated heart (guinea pigs), dorsal root, evoked by stimula- chromatography, determina- (dogs), 350 708 tion of raphe nuclei, dual ac- tion of fluphenazine, related Papaverine, effect on cardiac enhancement of spike fre- tions ofserotonin antagonists phenothiazine drugs and me- sarcolemmal 5’-nucleotidase quency adaption in neurons (cats), 99 tabolites (rabbits, man), 36 (rats), 489 by (sea hares), 222 membrane, of saphenous an- for tetracycline (rabbits, dogs), Parathyroid-hormone, -stimu- induction effect on carbamaze- tery, effect of reserpine (rab- 10 lated bone resorption, inhi- pine to carbamazepine-10,ii- bits), 430 of bupropion (dogs, rabbits, bition by ouabain (mice), 586 epoxide pathway (monkeys), slow inhibitory postsynaptic, in man, rats, mice), 602 Parkin, K. S., see Mather, L. E., 555 superior cervical ganglia, me- of halopenidol (rabbits, rats), 481 synergistic interaction with diation by catecholamine re- 757 Patel, I. H., Wedlund, P. and phenytoin (mice, rabbits), ceptors (rabbits), 440 of 5-hydroxyindoleacetic acid, Levy, R. H.: Induction effect 805 transmembrane, effects of N- use of iodinated derivative of phenobarbital on the car- Phenothiazines, determination by acetyl procainamide (dogs), (rabbits), 791 bamazepine to carbamaze- combined high-performance 851 of methadone (rats), 147 pine-10,11-epoxide pathway liquid chromatography and Prange, A. J., Jr., see Osbahr, A. to measure levels of morphine in rhesus monkeys, 555 radioimmunoassay (rabbits, J. III, 645 in plasma and brain (rats), Patil, P. N., see Fuder, H., 1 man), 36 Prazosin 181 Patrick, R. L., Berkowitz, A. L. Phenylethanolamine, physiologic alpha-i adrenoceptor selectiv- Rane, A., see Rollins, D., 697 and Regenstein, A. C.: Effects effects and plasma kinetics of ity of (cats, dogs), 467 Rappaport, S. C., see Vittek, J., of in vivo amphetamine ad- (dogs), 379 tolerance to, involvement of 411 ministration on dopamine Phenytoin renin-angiotensin system Receptors synthesis regulation in rat cytotoxicity, role of arene ox- (rats), 397 alpha adrenergic, blockade by brain striatal synaptosomes, ides (man, mice), 386 Price, J. D. E., see Tam, Y. K., tnimazosin (dogs), 333 686 synergistic interaction with 764 alpha adrenergic, interactions D-Peniclllamine, influence upon phenobarbital (mice, rab- Procainamide, effect on inotropic with neuroleptic metabolites seizure activity and trace bits), 805 action of p-ch!oromercuri- (sheep, rats), 81 metal status (baboons), 138 Phillips, A. P., see Butz, R. F., 602 benzoate in isolated heart alpha adrenergic, postsynaptic, Penicillins, semisynthetic (see Phosphorylase a, isoproterenol- (guinea pigs), 708 differentiation by yohimbine specific drug) stimulated formation in heart Propranolol (rats), 235 Pentobarbita! (mice), 326 effect on inotropic action of p- beta adrenergic, early develop- and phencyclidine, on fixed-in- Pickering, L. K. and Rutherford, chloromercunibenzoate in ment, effect of prenatal ex- terval performance (mon- I.: Effect of concentration isolated heart (guinea pigs), posure to imipramine (rats), keys), 61 and time upon inactivation of 708 461 drinking, role in pentobarbital- tobramycin, gentamycin, ne- pretreatment, effects on co- catecholamine, mediating cate- reinforced behavior (mon- tilmicin and amikacin by caine lethality (dogs), 350 cholamine hyperpolarization keys), 114 azlocilhin, carbenicillin, mecil- Prostacyclin, release from heart and slow inhibitory postsyn- effect on growth hormone so- linam, mezlocillin and piper- during hypersensitivity reac- aptic potential in superior cretion (rats), 152 acillin, 345 tions in vitro (guinea pigs), cervical ganglia (rabbits), 440 enhancement of spike fre- Pimozide, pretreatment, effects 157 dopamine, presynaptic, stimu- quency adaption in neurons on cocaine lethality (dogs), Prostaglandin, renal synthesis, lation in cardiovascular ac- by (sea hares), 222 350 dose-dependent stimulation tions of lergotrile (dogs), 660 Petschke, T., see Rilkind A. B., Piperacillin, inactivation of tobra- by deamino-8-o-arginine va- dopaminergic, aminophylline- 572 mycin, gentamicin, netilmicin sopressin (rats), 87 induced stimulation of respi- pH, dependent activity of H1- and and amikacin (man), 345 Prostaglandin F,,, effects on renal ration by activation of (rats), H2-histamine receptors in Plans-Bohne, F.: The influence of function (dogs), 674 215 gallbladder (guinea pigs), 638 chelating agents on the dis- Prostate, effect of ethanol on tes- dopaminergic, interactions with Pharmacodynamics, of minaxo- tnibution and biotransforma- tosterone-5a-reductase in neuroleptic metabolites lone (sheep), 481 tion of methylmercuric chlo- (rats), 411 (sheep, rats), 81 Pharmacokinetics (see also kinet- ride in rats, 500 Protamine, effect on resistance Hr and H2-histamine, pH-de- ics) Plasma and transport after coronary pendent activity in gallblad- dose-dependent, of metoclo- concentrations of anti-inflam- flow reduction (dogs), 62 der (guinea pigs), 638 pramide (rats), 764 matory agents, influence of Protein, deficiency, dietary, influ- muscaninic cholinergic, interac- of bupropion (dogs, rabbits, dietary protein deficiency ence on lysosome stabilizing tions with neuroleptic me- man, rats, mice), 602 (rats), 776 and paw edema suppressant tabolites (sheep, rats), 81 of carbamazepine, effects of kinetics, of phenylethanola- activity of anti-inflammatory nicotinic, in colon (rat), 828 phenobarbita! (monkeys), mine and N-methyl phenyl- agents (rats), 776 opiate, blockade, effect on an- 555 ethanolamine (dog), 379 Proudfit, H. K., see Larson, A. A., giotensin-induced drinking of dyphylline elimination in Plomp, G. J. J., Maes, R. A. A. 99 and vasopressin release uremia (man), 340 and van Rhee, J. M.: Dispo- Puizillout, J. J. and Delaage, M. (rats), 630 of methadone (rats), 147 sition of morphine in rat A.: Radioimmunoassay of 5- opioid, agonists, locomotor ac- Phenacemide, cytotoxicity, role of brain: Relationship to biolog- hydroxyindole acetic acid us- tivity and antinociception INDEX 881

after (rats), 451 enkephalin-analog, 228 in amphibian and mamma- nophylline-induced (rats), pulmonary J, stimulation by Sanders, D. B., see Caputy, A. J., han peripheral nerve, 719 215 enkephalin-analog (rats), 228 369 Smith, R. D., Tessman, D. K. and Stomach Regenstein, A. C., see Patrick, R. Schanberg, S. M., see Kuhn, C. Kaplan, H. R.: Acute toler- perfused, effects of clonidine on L., 686 M., 152 ance to prazosin in conscious gastric acid secretion in Reinke, L. A., Belinsky, S. A., Ev- Schauf, C. L., see Smith, K. J., 719 hypertensive rats: Involve- (rats), 121 ans, H. K., Kauffman, F. C. Schenker, S., see James, R., 127 ment ofthe renin-angiotensm steric aspects of alpha adreno- and Thurman, R. G.: Conju- Schlehuber, C., see Snyder, E. W., system, 397 receptors of (rabbit), 1 gation ofp-nitrophenol in the 299 Smooth muscle (see Muscle, Stone, H. L., see Gwirtz, P. A., 92 perfused rat liver: The effect Schlitt, S. C., see Olsen, G. D., 278 smooth) Strandhoy, J. W., see Zook, T. E., of substrate concentration Scholtholt, J., see Fiedler, V. B., Snyder, E. W., Dustman, R. E. 674 and carbohydrate reserves, 306 and Schlehuber, C.: Nalox- Strauss, H. C., see Dohrmann, M. 863 Schroeder, D. H., see Butz, R. F., one epileptogenesis in mon- L., 549 Renin-angiotensin system, in- 602 keys, 299 Stniatum volvement in tolerance to Schuster, C. R., see Killian, A. K., Sodium brain, effects of amphetamine prazosin (rats), 397 820 efflux in muscle fibers, effect of on dopamine synthesis in Reserpine Secretion halothane (barnacle), 248 (rats), 686 effects on monoamines and in- gastric acid, effects of clonidine entry to cerebrospinal fluid, ef- haloperidol levels, radioimmu- testinal transit (rats), 357 (rats), 121 fect ofcarbonic anhydrase in- noassay for (rabbits, rats), effect on sensitivity and mem- of growth hormone, maturation hibitors and other drugs on 757 brane potential of saphenous of central nervous system (rats), 51 site of dopamine formation artery (rabbits), 430 control of (rats), 152 Sodium channels after L-dopa (rats), 189 Respiration Seident, L. S., see Lucot, J. B., 738 blockage by chiriquitoxin tyrosine hydroxylase, effects of aminophylline-induced stimu- Seizures (frogs), 416 y-aminobutyric acid-elevat- lation by activation of dopa- and trace metal status, influ- grayanotoxin binding site ing agents on neuroleptic-in- minergic receptors (rats), 215 ence of D-penidillamine (ba- (frogs), 812 duced activation of(rats), 177 effect of theophylline and boons), 138 Sodium-potassium pump, sites in Summy-Long, J. Y., Keil, L. C., methadone interaction upon naloxone (monkeys), 299 smooth muscle (guinea pigs), Deen, K., Rosella, L. and (dogs), 278 Sengupta, K., Long, K. J. and Al- 692 Severs, W. B.: Endogenous Rifkind, A. B. and Petschke, len, D. 0.: Growth hormone Sodium pump, electrogenic, ef- opioid peptide inhibition of T.: p-Chloro-N-methylani- stimulation of lipolysis and fects of isoproterenol, dibu- the central actions of angio- line demethylase activity in cyclic AMP levels in perfused tyryl-cyclic AMP and theo- tensin, 619 liver and extrahepatic tissues fat cells, 15 phylline (rats, baboons, dogs, Summy-Long, J. Y., Keil, L. C., of the human fetus and in Sensitivity, of saphenous artery, pigs, cats), 26 Deen, K. and Severs, W. B.: chick embryo liver, 572 effect of reserpine (rabbits), Sodium valproate, enhancement Opiate regulation of angio- Roberts, J. G., see Mather, L. E., 430 of y-aminobutynic acid inhi- tensin-induced drinking and 481 Serotonin (see also 5-Hydroxy- bition (rats), 445 vasopressin release, 630 Robinson, R. L., see Abel, P. W., tryptamine) Southren, A. L., see Vittek, J., 411 Supersensitivity, colchicine-in- 430 antagonists, dual actions on Spann, J. F., see Borow, K. M., duced, in vas deferens, role of Rodgers, R. L., see MacLeod, K. dorsal root potentials evoked 566 changes in adrenergic nerves M., 798 by stimulation of raphe nu- Spector, S., see Wurzburger, R. J., for development of (rats), 516 Rollins, D., Larsson, A., Steen, B., clei (cats), 99 757 Krishnaswamy, K., Hagen- brain, effects of mazindol and Spielberg, S. P., Gordon, G. B., Tachibana, K., see Ohizumi, Y., feldt, L., Mold#{233}us, P. and homologs (rats), 745 Blake, D. A., Mellits, E. D. 475 Rane, A.: Glutathione and y- in brain and small intestine, ef- and Bross, D. S.: Anticonvul- Tam, Y. K., Axelson, J. E., Mc- glutamyl cycle enzymes in fects of reserpine (rats), 357 sent toxicity in vitro: Possible Erlane, B., Ongley, R. and human fetal liver, 697 levels, brain, effects of p-chlo- role of arene oxides, 386 Price, J. D. E.: Dose-depen- Romano, C.: Nicotine action on roamphetamine (rats), 738 Spike frequency adaption, in neu- dent pharmacokinetics of rat colon, 828 Serum, haloperidol levels, ra- rons, barbiturate enhance- metoclopramide in rat: An ef- Rosella, L., see Summy-Long, J. dioimmunoassay for (rabbits, ment of (sea hares), 222 fect of hemoperfusion?, 764 Y., 619 rats), 757 Spinal cord, sympathetic reflexes, Tashjian, A. H., Jr., see Knieger, Rosenshtraukh, L. V., see Gil- Severs, W. B., see Summy-Long, catecholamine effects on N. S., 586 mour, R. G., Jr., 390 J. Y., 619, 630 (frogs), 170 Temma, K., Akera, T., Brody, T. Ruffolo, R. R., Jr., Waddell, J. E. Seyama, I., see Masutani, T., 812 Spleen, isolated perfused, selec- M. and Kondo, H.: Positive and Yaden, E. L.: Postsyn- Shader, R. I., see Abernethy, D. tivities of prazocin and WB inotropic action of p-chlo- aptic alpha adrenergic recep- R., 681 4101 in (cats, dogs), 467 romercuribenzoate in iso- tor subtypes differentiated by Shannon, H. E., Cone, E. J. and SQ 14225, effects on metabolism lated guinea-pig heart: Influ- yohimbine in tissues from the Yousefnejad, D.: Physiologic of [3H]benzoyl-phenylalanyl- ence of membrane stabilizing rat. Existence of alpha-2 ad- effects and plasma kinetics of alanyl-proline by pulmonary agents, 708 renergic receptors in rat phenylethanolamine and its angiotensin converting en- Temperature aorta, 235 N-methyl homolog in the zyme in vivo (rabbits, dogs), body, comparison of effects of Rusy, B., see Helmer, P., 248 dog, 379 263 phenylethanolamine and N- Rutherford, I., see Pickering, L. Shepperson, N. B., see Mas- Steen, B., see Rollins, D., 697 methyl phenylethanolamine K., 345 singham, R., 467 Stewart, J. J. and Jobe, P. C.: on (dogs), 379 Shibata, S., see Ohizumi, Y., 475 Effects of reserpine on mono- dependence of ethanol depres- Saito, A., Kasuya, Y. and Goto, Shimizu, M., see Masuda, Y., 805 amines and intestinal transit sion on (mice), 770 K.: The role ofmorphological Shinnick-Gallagher, P., see Cole, in the rat, 357 Tephly, T. R., see Eells, J. T., 57 and functional changes in ad- A. E., 440 Stimulation Terakawa, M., Tsuchiya, T., Wa- renergic nerves for the devel- Shinnick-Gallagher, P., see Un- electrical, of raphe nuclei, dual tanabe, Y. and Noguchi, H.: opment ofcolchicine-induced desser, E. K., 170 actions of serotonin antago- Renal excretion and distri- supersensitivity in the rat vas Shiraishi, Y., see Masuda, Y., 805 mats on dorsal root potentials bution of ceftizoxime in rats, deferens, 516 Smiowitz, H., see Cheng, K.-C., evoked by (cats), 99 209 Saline, discrimination (rats), 254 44 of pulmonary J receptors by en- Tessman, D. K., see Smith, R. D., Sapru, H. N., Willette, R. N. and Smith, K. J. and Schauf, C. L: kephalin-analog (rats), 228 397 Knieger, A. J.: Stimulation of Effects of gallamine triethio- of respiration by activation of Testosterone-5a-reductase, in pulmonary J receptors by an dide on membrane currents dopaminergic receptors, ami- oral tissues, effect of ethanol 882 INDEX

(rats), 411 Transmission Vasopressin 652 Tetracycline, radioimmunoassay cholinergic, effects of/3-bungar- release, angiotensin-induced, Woodward, J. K., see Cheng, H. for (rabbits, dogs), 10 otoxin (guinea pigs, rabbits, opiate regulation of (rats), C., 121 Tetrodotoxin, comparison with rats, mice), 505 630 Woolverton, W. L. and Balster, R. chinquitoxin (frogs), 416 neuromuscular, in skeletal mus- release, effects of interaction L.: Effects of combinations of Theophylline cle, comparison of effects of between angiotensin and phencyclidine and pentobar- effect on cardiac sarcolemmal antibiotics on (rats), 369 opioid peptides (rats), 619 bital on fixed-interval per- 5’-nucleotidase (rats), 489 neuromuscular, postsynaptic Vatner, S. F., see Macho, P., 333 formance in rhesus monkeys, effect upon respiration and yen- inhibition by trifluoperazine Veins, effect of hydralazine, in vi- 611 tilation, interaction with (chicks, frogs), 44 tro comparison to arteries Wurtman, R. J., see Hefti, F., 189 methadone (dogs), 278 synaptic, in sympathetic gan- (man), 204 Wurzburger, R. J., Miller, R. L., relaxation of vascular smooth glia, effects of 5-hydroxytryp- Ventilation, effect of theophylline Marcum, E. A., Colburn, W. muscle by (rats, baboons, tamine (rabbits), 714 and methadone interaction A. and Spector, S.: A new dogs, pigs, cats), 26 Trifluoperazine, postsynaptic in- upon (dogs), 278 radioimmunoassay for halo- Thiamine, deficiency, impairment hibition of neuromuscular Ventricle, left, dynamics, effects peridol: Direct measurement of behavior and acetylcholine transmission by (chicks, of tnimazosin (dogs), 333 of serum and striatal concen- metabolism in (rats), 537 frogs), 44 Vittek, J., Gordon, G. G., South- trations, 757 1-Thiocarbamoyl-2-imidazolidi- Trimazosin, effects on coronary ren, A. L, Rappaport, S. C., none, formation from nirida- and left ventricular dynamics Munnangi, P. R. and Lieber, Xylamine, actions on central nor- zole in intestine (mice), 363 (dogs), 333 C. S.: Effect of ethanol intake adrenergic neurons (rats), Thioridazine, comparison of in vi- Tsuchiya, T., see Terakawa, M., on cellular regulation of tes- 834 tro potency at dopaminergic, 209 tosterone-5a-reductase in rat alpha adrenergic and mus- Tyrosine hydroxylase, striate!, ef- oral tissues, 411 carmnic cholinergic receptor fects of y-aminobutynic acid- Vogh, B. P. and Doyle, A. S.: The Yaden, E. L., see Ruffolo, R. R., binding sites (sheep, rats), 81 elevating agents on neurolep- effect of carbonic anhydrase Jr., 235 Thromboxane, release from heart tic-induced activation of inhibitors and other drugs on Yamamoto, S., Akera, T., Kim, during hypersensitivity reac- (rats), 177 sodium entry to cerebrospi- D.-H. and Brody, T. M.: Tis- tions in vitro (guinea pigs), nal fluid, 51 sue concentration of Na,K- 157 Umans, J. G., see Ling, G. S. F., adenosine tniphosphatase Thurman, R. G., see Reinke, L. Waddell, J. E., see Ruffolo, R. R., 147 and the positive inotropic ac- A., 863 Jr., 235 Undesser, E. K., Schinnick-Gal- tion of ouabain in guinea-pig Thyrotropin-releasing hormone, Wainer, B. H., see Killian, A. K., lagher, P. and Gallagher, J. heart, 701 antagonism of neurotensin- 820 P.: Catecholamine modula- Yeoh, P. N., see Kao, C. Y., 416 induced antinociception Walker, L. A. and Fr#{246}lich,J. C.: tion ofspinal sympathetic re- Yohimbine, differentiation of (mice), 645 Dose-dependent stimulation flexes, 170 postsynaptic alpha adrener- Tissues of renal prostaglandin syn- Uptake, pulmonary amine, effect gic receptors in tissues by concentration of Na,K-aden- thesis by deamino-8-D-argi- of bleomycin (rabbits), 524 (rats), 235 osine triphosphatase in heart nine vasopressin in rats with Uremia, pharmacokinetics of dy- Yoshida, K., see Masuda, Y., 805 (guinea pigs), 701 hereditary diabetes insipidus, phylline elimination in Yousefnejad, D., see Shannon, H. fetal, p-chloro-N-methylani- 87 (man), 340 E., 379 lane demethylase activity in Wang, L H., see Lee, C-S. C., 340 Urine, volume and electrolytes, Yue, T. L. and Varma, D. R.: In- (man, chicks), 572 Watanabe, Y., see Terakawa, M., central effects of morphine, fluence of protein deficiency oral, effect of ethanol on testos- 209 levorphanol, methadone and on lysosome stabilizing and terone-5a-reductase in (rats), Waters, I. W., see Catravas, J. D., endorphins (rats), 579 paw edema suppressant ac- 411 350 Urquilla, P. R., see Abel, P. W., tivity ofsteroidal and nonste- WB41O1, alpha-i adrenoceptor respiratory, response and son- 430 roidal anti-inflammatory sitivity to histamine, effects selectivity of (cats, dogs), 467 Utsui, Y., see Masuda, Y., 805 agents in rats, 776 of cyclooxygenase and lipoxy- Webb, R C. and Bohr, D. F.: Re- genase inhibition (guinea laxation of vascular smooth pigs), 592 Valentino, R. J., Herling, S., muscle by isoproterenol, di- Zacharov, S. I., see Gilmour, R. Tobramycin, inactivation by azlo- Woods, J. H., Medzihradsky, butyryl-cyclic AMP and G., Jr., 390 dim, carbenicillin, mecilli- F. and Merz, H.: Quaternary theophylline, 26 Zbicz, K. L. and Wilson, W. A.: nam, mezlocillin and pipera- naltrexone: Evidence for the Webster, L. T., Jr., see Tracy, J. Barbiturate enhancement of cillin (man), 345 central mediation of discrim- W., 363 spike frequency adaptation in Tolerance, to prazosin, involve- inative stimulus effects of Wedlund, P., see Patel, I. H., 555 Aplysia giant neurons, 222 ment of renin-angiotensin narcotic agonists and antag- Welch, R. M., see Butz, R. F., 602 Zinc system (rats), 397 onists, 652 Westfall, D. P., see Abel, P. W., inhibition of in vitro histamine Toxicity (see also cytotoxicity) Vanadate, renal vascular and tu- 430 release from basophils (man), bleomycin, biochemical mark- bular effects of (rats), 406 White, J. M. and Holtzman, S. G.: 292 ens of (rabbits), 524 van Rhee, J. M., see Plomp, G. J. Three-choice drug discrimi- serum concentrations and sei- digitalis, effect of canrenone J., 181 nation in the rat: Morphine, zures, influence of D-penicil- (guinea pigs), 784 Van Vunakis, H., see Goldstein, S. cyclazocine and saline, 254 lamine (baboons), 138 Trachea, alpha-i and alpha-2 ad- A., 36 Willette, R. N., see Sapru, H. N., Zipes, D. P., see Gilmour, R. G., renergic receptors in (dogs), Varma, D. R., see Yue, T. L, 776 228 Jr., 390 530 Vas deferens Wilson, S. E., see Levin, J. A., 162 Zook, T. E. and Strandhoy, J. W.: Tracy, J. W. and Webster, L. T., actions of ciguatoxin in (guinea Wilson, W. A., see Zbicz, K. L, Mechanisms of the natri- Jr.: The formation of 1-thio- pigs), 475 222 uretic and diuretic effects of carbamoyl-2-imidazolidinone role of changes in adrenergic Wise, W. E., see La Morte, W. W., prostaglandins F2,,, 674 from niridazole in mouse in- nerves for development of 638 Zysset, T. and Bircher, J.: Pref- testine, 363 colchicine-induced supersen- Withdrawal, of ethanol, sponta- erential reduction of first- Transmembrane currents, in sitivity (rats), 516 neous hind leg movements pass elimination by ethanol. atria, effect of aprindine on smooth muscle, Na-K-pump (rats), 666 Model experiments with do- (frogs), 390 site (guinea pigs), 692 Woods, J. H., see Valentino, R J., methiazole in the rabbit, 198 Tap into the broadest international coverage of the rnostr S I cal science /

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F. Drago, G. Gorgone, F. Spina, G. Panissidi, M. Kohlhardt, C. Seifert: Inhibition of Vmax of A. Dal Bello, F. Moro, U. Scapagnini : Opiate the Action Potential by Propafenone and Its Receptors in the Rabbit Iris 1 Voltage-, Time- and pH-Dependence in Mammalian Ventricular Myocardium 55 R. F. Bruns: Adenosine Receptor Activation by Adenine Nucleotides Requires Conversion of the M. A. Evans : Effects of Anticonvulsants and Nucleotides to Adenosine 5 Methotrexate on Calcium Disposition 63 V. Koga, H. Downes, S. M.Taylor: Direct and T. Kishimoto, N. Urakawa : The Inhibitory Effect Indirect Actions of Dopamine on Tracheal Smooth of Lithium on High-K Induced Contraction in Muscle 15 Guinea-Pig Taenia Coli 69 w, Kobinger, 1. Pichler: Relation Between C.J.Duncan, H. C. Greenaway, J. L. Smith: Central Sympathoinhibitory and Peripheral Pre- 2,4- Dinitrophenol, Lysosomal Breakdown and and Postsynaptic a-Adrenoceptors as Evaluated by Rapid Myofilament Degradation in Vertebrate Different Clonidine-Like Substances in Rats 21 Skeletal Muscle 77 s.J. Publicover, C.J. Duncan: Stimulation of the Frequency of MEPPs at the Frog Short Communications Neuromuscular Junction by Extracellular EGTA 29 J. M#{246}hring, J. Schoun, J. Kintz, R. McNeill: Decreased Vasopressin Content in Brain Stem of H. C. Moises, B. J. Hoffer, D. J. Woodward: Rats with Spontaneous Hypertension 83 GABA Facilitation by Noradrenaline Shows Supersensitivity in Cerebellum after N. Rohm, J. Wagner, H. J. SchUmann : The 6-Hydroxydopamine 37 Lack of a Pronounced Preference of Prenalterol for the Beta-i -Adrenoceptor Subtype 85 T. Ehara, M. Inazawa: Calcium-Dependent Slow Action Potentials in Potassium- Depolarized Guinea-Pig Ventricular Myocardium Enhanced by Barium Ions 47 Indexed in Current Contents

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