C A T INGURUMEN KUTSADURA ETA TOXIKOLOGIA CONTAMINACION Y TOXICOLOGIA AMBIENTALES ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY GRADUONDOKO MASTERRA / MASTER DE POSTGRADO UPV/EHU

EMSc European Master of Science in Marine Environment and Resources MER SOTON, UPV/EHU, UBx1, AZTI, OFG - 2007-2008 JOINT EUROPEAN POSTGRADUATE STUDIES

INTERNATIONAL POSTGRADUATE COURSE

CELLULAR AND MOLECULAR BIOMARKERS (3 ECTS) June 2-6, 2008, UPV/EHU, Leioa.

Organized by: CTA and MER Masters (UPV/EHU) Department of Zoology and Cell Biology, Faculty of Science and Technology, Univ Basque Country,

Teaching Staff: Miren P. Cajaraville (UPV/EHU, Leioa, Basque Country) Course Coordinator Angela Köhler (AWIi-Bremerhaven, Germany) Amaia Orbea (UPV/EHU, Leioa, Basque Country) Maren Ortiz-Zarragoitia (UPV/EHU, Leioa, Basque Country) Manu Soto (UPV/EHU, Leioa, Basque Country)

Additional information: Prof. Miren P. Cajaraville ([email protected]) Department of Zoology and Cell Biology Faculty of Sciences and Technology University of the Basque Country, Leioa-Basque Country Telf: 34 946012697, Fax: 34 946013500 www:http://www.ehu.es/CTA www:http://www.ehu.es/MER

Supporting Institutions: • University of the Basque Country (Vicerrectorate of Graduate & Postgraduate Studies) • Basque Government, Education, Universities & Research Dept (teaching staff mobility programme) • Ministry of Education and Science (MEC, teaching staff mobility programme)

*Quality Award by Spanish Ministry of Education and Science (2005-2008)

Introduction

The International Postgraduate Course on Cellular and Molecular Biomarkers (3 ECTS) will take for one week in June 2-6, 2008.

The course is directed to postgraduate or PhD students aiming to become specialized in the field of environmental toxico(patho)logy, with a focus in cellular and molecular biomarkers of pollution. All lectures will be held in English.

Participants will receive a certificate with indication of lectures and practicals attended.

Students who request it will receive the same academic treatment than the official students enrolled in the CTA and MER Masters and will be given marks after examination. Thus, together with the attendance certificate, a supplementary certificate indicating the obtained marks (and ECTS) will be provided (complete certificate)

Registration

The course is limited to 20 participants. The registration fee is 250 € and includes attendance to all lectures and lab practicals and course documentation.

For registration, participants should fill in the registration form and send it to Prof. Miren P. Cajaraville before the 16th May 2008, together with a check payable to “CMB Course,BCTA (UPV/EHU)” or a copy of the bank document indicating that a bank transfer has been made to the bank: BILBAO BIZKAIA Branch: 0260, Unibertsitatea, Leioa E-48940 Leioa, Basque Country, Account Number: 2095 0260 80 9105923720 For international transfers: IBAN ES94 2095 0260 8091 0592 3720; SWIFT: BASKES2BXXX

Registrations after this date might be only exceptionally accepted. All participants will receive a receipt of payment and notification of acceptance in the course.

Accommodation

Accommodation may be booked at the student’s residence “Colegio Mayor Miguel de Unamuno”, which is located in Bilbao city center, very close to a metro station and is connected by bus to the campus of Leioa, where the course will take place. Rooms are offered at a price around 45€ per night including breakfast. Rooms have individual bathroom inside, television and room service. Optional dinner service is available (7 €). Lunches will take place at the campus (around 6 €). Participants wishing to get accommodation in the Residence Unamuno should fill in the application form available at www.ehu.es/Unamuno and send it (preferably by fax and giving the reference of “CMB course BCTA (UPV/EHU)08”) to the following address: Colegio Mayor Miguel de Unamuno Avda. Lehendakari Agirre, 140, 48015 Bilbao Tln: 94-6017499, Fax: 944764147 e-mail: [email protected] http://www.ehu.es/unamuno/general.html

• Other student’s residences available are “Residencia Universitaria Blas de Otero” in Bilbao and “Residencia de Estudiantes de Plentzia” in the small coastal town of Plentzia. You can get more information on these and other student’s residences in the web page of the university (www.ehu.es, student information, servicio de alojamiento).

PROGRAMME

Monday, 2nd June

9:30-11:10: LECTURE: Introduction to cellular and molecular biomarkers of pollution: examples and applications in monitoring programmes. Miren P Cajaraville. 11:30-13:10: LECTURE: Biomarkers for assessment of toxicant-caused DNA damage. Miren P Cajaraville.

14:30-18:30: LAB PRACTICAL: Genotoxicity assessment.

Tuesday, 3rd June

9:30-11:10: LECTURE: Biotransformation of organic xenobiotics. Amaia Orbea. 11:30-13:10: LECTURE: Toxicity of metallic pollutants in relation with cellular accumulation and storage processes. Manu Soto.

14:30-18:30: LAB PRACTICAL: Biomarkers of exposure to metals.

Wednesday, 4th June.

9:30-11:10: LECTURE: The MXR system and other ABC transport proteins in environmental health and toxicology. Angela Köhler. 11:30-13:10: LECTURE: Mechanisms of pollutant-induced peroxisome proliferation and rationale for use as exposure biomarker in environmental pollution assessment. Miren P. Cajaraville.

14:30-18:30: LAB PRACTICAL: Assessment of peroxisome proliferation.

Thursday, 5th June.

9:30-11:10: LECTURE: Generation of oxyradicals and oxidative stress in marine organisms. Amaia Orbea. 11:30-13:10: LECTURE: Lysosomal perturbations as indicators for toxically induced cell damage. Angela Köhler.

14:30-18:30: LAB PRACTICAL: Lysosomal biomarkers.

Friday, 6th June.

9:30-11:10: LECTURE: Biomarkers and bioassays for endocrine disrupting environmental pollutants. Maren Ortiz-Zarragoitia. 11:30-13:10: LECTURE: Challenges for use of biomarkers in environmental monitoring and risk assessment. Miren P. Cajaraville.

June 2-6, 2008, SCHOOL SCI & TECHNOL, UPV/EHU

Registration form: CMB Course 2008 (UPV/EHU)

Surname………………….…...... ……………………………………………………………

Name…………...... ………………………………………………………………………..

Title………………………..……...... ……………………………………………………………..

Postal address…………………...... ………………………………………………………..

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Postal code………………City/Town……………………..Country…………...... ……………………..

Telephone....…………………………...... ………………………………………………......

Fax…………………………………………….. e-mail……………………………………………

I need accommodation in the student’s residence: YES NO

SIGNATURE: PLACE AND DATE:

The completed and signed form should be submitted to Prof. Miren P. Cajaraville*, before May 16th 2008 together with a (a) bank check (250 €) for “CMB Course, BCTA (UPV/EHU)” or (b) copy of bank transfer to BBK Account Number: 2095 0260 80 9105923720 indicating “CMB Course, BCTA (UPV/EHU)”. For international transfers: IBAN ES94 2095 0260 8091 0592 3720; SWIFT: BASKES2BXXX

Prof. Miren P. Cajaraville Department of Zoology and Cell Biology Faculty of Science and Technology University of the Basque Country Leioa-Basque Country (Spain) Tln: 34 946012697; Fax: 34 944648500 e-mail: [email protected]