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Prevalence of Endocrine Disorders in Obese Patients: Systematic Review and Meta-Analysis

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Prevalence of Endocrine Disorders in Obese Patients: Systematic Review and Meta-Analysis 1 182 L T van Hulsteijn and others Prevalence of endocrine 182:1 11–21 Clinical Study disorders in obesity Prevalence of endocrine disorders in obese patients: systematic review and meta-analysis L T van Hulsteijn1, R Pasquali2, F Casanueva3, M Haluzik4, S Ledoux5, M P Monteiro6,7, J Salvador8,9, F Santini10, H Toplak11 and O M Dekkers12,13,14 1Department of Clinical Endocrinology and Metabolism, University Medical Centre Groningen, Groningen, The Netherlands, 2University Alma Mater Studiorum, Bologna, Italy, 3Department of Medicine, Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago (CHUS), CIBER de Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Santiago de Compostela, Spain, 4Diabetes Centre and Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine and Institute of Endocrinology, Prague, Czech Republic, 5Department of Physiology, Obesity Center, Louis Mourier Hospital (APHP), Colombes and Paris Diderot University, Paris, France, 6Endocrine, Cardiovascular & Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Oporto, Porto, Portugal, 7Honorary Clinical Senior Lecturer and Obesity Consultant, University College of London, London, UK, 8Department of Endocrinology and Nutrition, University Clinic of Navarra, Pamplona, Spain, 9CIBEROBN, Instituto Carlos III, Madrid, Spain, 10Obesity and Lipodystrophy Center, University Hospital of Pisa, Pisa, Italy, 11Division of Endocrinology Correspondence and Diabetology, Department of Medicine, Medical University of Graz, Graz, Austria, 12Department of Clinical should be addressed Epidemiology, 13Department of Clinical Endocrinology and Metabolism, Leiden University Medical Centre, Leiden, to L T van Hulsteijn The Netherlands, and 14Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark Email [email protected] Abstract Objective: The increasing prevalence of obesity is expected to promote the demand for endocrine testing. To facilitate evidence guided testing, we aimed to assess the prevalence of endocrine disorders in patients with obesity. The review was carried out as part of the Endocrine Work-up for the Obesity Guideline of the European Society of Endocrinology. Design: Systematic review and meta-analysis of the literature. European Journal of Endocrinology Methods: A search was performed in MEDLINE, EMBASE, Web of Science and COCHRANE Library for original articles assessing the prevalence of hypothyroidism, hypercortisolism, hypogonadism (males) or hyperandrogenism (females) in patients with obesity. Data were pooled in a random-effects logistic regression model and reported with 95% confidence intervals (95% CI). Results: Sixty-eight studies were included, concerning a total of 19.996 patients with obesity. The pooled prevalence of overt (newly diagnosed or already treated) and subclinical hypothyroidism was 14.0% (95% CI: 9.7–18.9) and 14.6% (95% CI: 9.2–20.9), respectively. Pooled prevalence of hypercortisolism was 0.9% (95% CI: 0.3–1.6). Pooled prevalence of hypogonadism when measuring total testosterone or free testosterone was 42.8% (95% CI: 37.6–48.0) and 32.7% (95% CI: 23.1–43.0), respectively. Heterogeneity was high for all analyses. Conclusions: The prevalence of endocrine disorders in patients with obesity is considerable, although the underlying mechanisms are complex. Given the cross-sectional design of the studies included, no formal distinction between endocrine causes and consequences of obesity could be made. European Journal of Endocrinology (2020) 182, 11–21 Introduction 10–30% of adults in European Union countries (http:// www.euro.who.int/en/health-topics/noncommunicable- The prevalence of obesity is rapidly increasing. According diseases/obesity/data-and-statistics). Although most to the World Health Organization, obesity now affects https://eje.bioscientifica.com © 2020 European Society of Endocrinology Published by Bioscientifica Ltd. https://doi.org/10.1530/EJE-19-0666 Printed in Great Britain Downloaded from Bioscientifica.com at 09/29/2021 11:11:14PM via free access -19-0666 Clinical Study L T van Hulsteijn and others Prevalence of endocrine 182:1 12 disorders in obesity cases of obesity are related to the interaction between hormone levels) if possible. Eligible articles should present unfavorable genes and a sedentary lifestyle and increased data on endocrine disorders based on biochemical tests. caloric intake, in a small proportion, secondary causes can We relied on the choice of endocrine tests as presented in be identified. These causes include endocrine conditions included articles and the definition of a positive test was such as hypothyroidism, hypercortisolism or hypo-(males) based on cut-off values provided in included articles. The or hyperandrogenism (females). The European Guidelines prevalence of an endocrine disorder was defined as the for Obesity Management in Adults therefore state that number of positively tested (or known treated) patients history taking should consider endocrine abnormalities divided by the total number of tested patients. and that laboratory examinations should include thyroid In order to avoid the inclusion of case reports or case function for every obese patient, and an endocrine series, which are more prone to selection and publication evaluation for Cushing’s syndrome in case of clinical bias, only studies reporting a population of ten or more suspicion (1). The AACE/ACE Guidelines for Medical Care patients with obesity were eligible. In case of multiple of Patients with Obesity state that biochemical testing for studies describing the same cohort, the study which hypothyroidism or hypercortisolism is indicated if related comprised the highest number of subjects was included. clinical findings or symptoms are present (2). Eligible studies were restricted to languages familiar to the The increasing prevalence of obesity is expected to authors (English, French, German, Dutch and Spanish). promote the demand for endocrine testing. However, Articles that were irretrievable online were requested obesity and above mentioned endocrine disorders by contacting the authors. We also tried to contact the share many clinical characteristics and therefore the authors for clarification when reported data were not precise merits of biochemical testing for endocrine sufficient for accurate data extraction. disorders in obese patients remain unclear. For evidence- guided testing, detailed knowledge of the prevalence Search strategy of endocrine conditions in obesity is a prerequisite. The objective of this study was to perform a systematic In May 2018, PubMed, EMBASE, Web of Science and review and meta-analysis on the prevalence of endocrine COCHRANE were searched to identify potentially relevant disorders (i.e. hypothyroidism, hypercortisolism or studies, published from 1980 onward (Supplementary hypo- or hypergonadism) in patients with obesity. The data 1, see section on supplementary materials given at review was carried out as part of the Endocrine Work-up the end of this article). References of key articles were for the Obesity Guideline of the European Society of assessed for additional relevant articles. European Journal of Endocrinology Endocrinology. Data extraction Methods All studies obtained from the search strategy were entered into reference manager software (EndNote X8, Clarivate Eligibility criteria Analytics, Philadelphia, PA) and were screened on title and abstract. Potentially relevant studies were retrieved Cross-sectional studies assessing the prevalence of for detailed assessment. For eligible studies, data were endocrine disorders in obese patients were eligible for independently extracted by two reviewers (L T v H and inclusion. Studies including patients with obesity (BMI >30 O D). Disagreements between reviewers were resolved by kg/m2) or an increased waist circumference (determined consensus. by region- and ethnic-specific cut-off point values, see under ‘Risk of bias assessment’) were eligible; also studies with stratified data for the groups mentioned above Risk of bias assessment were considered. The following endocrine conditions Risk of bias assessment was based on design elements were considered: hypothyroidism, hypercortisolism, that potentially bias an association between the exposed hypogonadism (males) and hyperandrogenism (females). population under study (patients with obesity) and the With regard to hypothyroidism, a distinction was made outcome (endocrine disorders) (3): between clinical (i.e. raised thyroid-stimulating hormone (TSH) and low free thyroid hormone levels) and subclinical 1. Selection of patients. Inclusion of consecutive exposed hypothyroidism (i.e. raised TSH, normal free thyroid patients, not selected for endocrine testing because of https://eje.bioscientifica.com Downloaded from Bioscientifica.com at 09/29/2021 11:11:14PM via free access Clinical Study L T van Hulsteijn and others Prevalence of endocrine 182:1 13 disorders in obesity a high pre-test probability for endocrine conditions in STATA (8). Given the expected clinical heterogeneity (e.g. only females with obesity and hirsutism tested a random-effects model was performed by default. for androgen excess) and exclusion of patients in Meta-analysis was performed using an exact likelihood whom biochemical testing could be unreliable (e.g. approach. For all analyses, indices of heterogeneity, I2 use
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