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United States Patent (10) Patent No.: US 7,657,310 B2 Buras (45) Date of Patent: Feb

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United States Patent (10) Patent No.: US 7,657,310 B2 Buras (45) Date of Patent: Feb USOO765731 OB2 (12) United States Patent (10) Patent No.: US 7,657,310 B2 Buras (45) Date of Patent: Feb. 2, 2010 (54) TREATMENT OF REPRODUCTIVE 4,867,164 A 9, 1989 Zabara ENDOCRINE DISORDERS BY VAGUS NERVE 4.909,263 A 3/1990 Norris ......................... 6O7/39 STMULATION 4,920,979 A 5, 1990 Bullara 5,025,807 A 6, 1991 Zabara (75) Inventor: William R. Buras, Friendswood, TX 5,074,868 A 12/1991 Kuzmak (US) 5,154,172 A 10/1992 Terry, Jr. et al. 5,179,950 A 1/1993 Stanislaw (73) Assignee: Cyberonics, Inc., Houston, TX (US) 5, 186,170 A 2f1993 Varrichio et al. (*) Notice: Subject to any disclaimer, the term of this 5,188,104 A 2f1993 Wernicke et al. patent is extended or adjusted under 35 U.S.C. 154(b) by 17 days. (21) Appl. No.: 11/340,309 (Continued) (22) Filed FOREIGN PATENT DOCUMENTS 22) Filed: Jan. 26, 2006 9 EP 1145736 10, 2001 (65) Prior Publication Data US 2007/O173891 A1 Jul. 26, 2007 (51) Int. Cl (Continued) A61N L/00 (2006.01) OTHER PUBLICATIONS (52) U.S. Cl. .......................................................... 6O7/2 (58) Field of Classification Search ..................... o, PCT US2007.000342 search Report (Aug. 30, 2007). 607/3, 45, 116, 118, 39, 46 (Continued) See application file for complete search history. Primaryy Examiner—George9. Manuel (56) References Cited (74) Attorney, Agent, or Firm—Williams, Morgan & U.S. PATENT DOCUMENTS Amerson P.C.; Timothy L. Scott 3,796,221 A 3/1974 Hagfors (57) ABSTRACT 4,305.402 A 12/1981 Katims 4.338,945 A 7, 1982 Kosugi et al. 4.424,812 A 1, 1984 Lesnick I disclose a method of treating a reproductive endocrine dis 4,431,000 A 2f1984 Butler et al. order in a patient, including coupling at least one electrode to 4.459,989 A 7, 1984 Borkan at least one portion of a cranial nerve of the patient; and 4,503,863. A 3, 1985 Katims applying an electrical signal to said cranial nerve using said 4,541,432 A 9/1985 Molina-Negro et al. 4,573,481 A 3, 1986 Bullara electrode to treat said reproductive endocrine disorder. 4,590,946 A 5, 1986 Loeb Among the reproductive endocrine disorders which may be 4,592,339 A 6, 1986 Kuzmak et al. treated by the method are gonadal dysgenesis, hypogo 4,612,934. A 9, 1986 Borkan nadism, hypergonadism, delayed puberty, amenorrhea, infer 4,702.254 A 10, 1987 Zabara tility, premature menopause, and polycystic ovarian disease. 4,793,353 A 12/1988 Borkan 4,865,048 A 9, 1989 Eckerson 22 Claims, 11 Drawing Sheets 42 25 Nase NEURONS --- 00 IMPANTAB MCADWIC 155 (e.g., NEUROSTIMULATOR) CONTROLLER The mair trunk or a branch of the right and/or left vagus nerve COMMUNICATION INTERFACE US 7,657,310 B2 Page 2 U.S. PATENT DOCUMENTS 6,241,704 6, 2001 Peterson et al. 6,243,607 6, 2001 Mintchev et al. 5,194,426 3, 1993 DaVanzo et al. 6,269,270 T/2001 Boveja 5,199.430 4, 1993 Fang et al. 6,295.472 9, 2001 Rubinstein et al. 5,205.285 4, 1993 Baker, Jr. 6,304,775 10, 2001 Iasemidis et al. 5,215,086 6, 1993 Terry, Jr. et al. 6,321,124 11, 2001 Cigaina 5,215,089 6, 1993 Baker, Jr. 6,327,503 12, 2001 Familoni 5,222.494 6, 1993 Baker, Jr. 6,337,997 1, 2002 Rise 5,226,429 7, 1993 Kuzmak 6,339,725 1, 2002 Naritoku et al. 5,231,988 8, 1993 Wernicke et al. 6,341,236 1, 2002 Osorio et al. 5,235.980 8, 1993 Varrichio et al. 6,356,784 3, 2002 Lozano et al. 5,237,991 8, 1993 Baker, Jr. et al. 6,356,786 3, 2002 Rezai et al. 5,263.480 11, 1993 Wernicke et al. 6,356,787 3, 2002 Rezai et al. 5,269,303 12, 1993 Wernicke et al. 6,356,788 3, 2002 Boveja 5,299,569 4, 1994 Wernicke et al. 6,366,814 4, 2002 Boveja et al. 5,304.206 4, 1994 Baker, Jr. et al. 6,374,140 4, 2002 Rise 5,311,876 5, 1994 Olsen et al. 6,381,495 4, 2002 Jenkins 5.330,507 T. 1994 Schwartz 6,418,344 T/2002 Rezai et al. 5.330,515 T. 1994 Rutecki et al. 6.425,852 T/2002 Epstein et al. 5,335,657 8, 1994 Terry, Jr. et al. 6,429,217 8, 2002 Puskas 5,423,872 6, 1995 Cigaina 6,438,423 8, 2002 Rezai et al. 5,501,702 3, 1996 Plicchi et al. 6,449,512 9, 2002 Boveja 5,514, 175 5, 1996 Kim et al. 6.463,328 10, 2002 John 5,540,730 T. 1996 Terry, Jr. et al. 6,466,822 10, 2002 Pless 5,540,734 T. 1996 Zabara 6,473,644 10, 2002 Terry, Jr. et al. 5,571,150 11, 1996 Wernicke et al. 6,477.418 11, 2002 Plicchi et al. 5,601,604 2, 1997 Vincent 6,477,423 11, 2002 Jenkins 5,611,350 3, 1997 John 6,484,132 11, 2002 Hively et al. 5,645,570 7, 1997 Corbucci 6,505,074 1, 2003 Boveja et al. 5,665,706 9, 1997 DaVanzo et al. 6,532,388 3, 2003 Hill et al. 5,690,681 11, 1997 Geddes et al. 6,535,764 3, 2003 Imran et al. 5,690,688 11, 1997 Noren et al. 6,542,776 4/2003 Gordon et al. 5,690,691 11, 1997 Chen et al. 6,549,804 4/2003 Osorio et al. 5,700.282 12/1997 Zabara 6,556,868 4, 2003 Naritoku et al. 5,702,428 12, 1997 Tippey et al. 6,560,486 5/2003 Osorio et al. 5,707.400 1, 1998 Terry, Jr. et al. 6,564,102 5/2003 Boveja 5,743,860 4, 1998 Hively et al. 6,571,125 5/2003 Thompson 6, 1998 Jakobsson 5,771,903 6,587,719 T/2003 Barrett et al. - - - - - - - - - - - - - - - - - - 6O7.2 5,792.212 8, 1998 Weijand 6,587,726 T/2003 Lurie et al. 5,836,994 11, 1998 Bourgeois 6,587,727 T/2003 Osorio et al. 5,861,014 1, 1999 Familoni 6,591, 137 T/2003 Fischell et al. 5,913,882 6, 1999 King 6,591, 138 T/2003 Fischell et al. 5,916,239 6, 1999 Geddes et al. 6,600,953 T/2003 Flesler et al. 5,919,216 7, 1999 Houben et al. 6,600,956 T/2003 Maschino et al. 5,928,272 7, 1999 Adkins et al. 6,606,518 8, 2003 Cigaina 5,935,099 8, 1999 Peterson et al. 6,606.523 8, 2003 Jenkins 5,978,702 11, 1999 Ward et al. 6,609,025 8, 2003 Barrett et al. 5,995,868 11, 1999 Dorfmeister et al. 6,609,030 8, 2003 Rezai et al. 5,995,872 11, 1999 Bourgeois 6,610,713 8, 2003 Tracey 6,009,877 1, 2000 Edwards 6,611,715 8, 2003 Boveja 6,024,539 2, 2000 Blomquist 6,612,983 9, 2003 Marchal 6,026,326 2, 2000 Bardy 6,615,081 9, 2003 Boveja 6,041,258 3, 2000 Cigaina et al. 6,615,084 9, 2003 Cigaina 6,044,846 4, 2000 Edwards 6,615,085 9, 2003 Boveja 6,083,249 T/2000 Familoni 6,622,038 9, 2003 Barrett et al. 6,091,992 T/2000 Bourgeois et al. 6,622,041 9, 2003 Terry, Jr. et al. 6,092,528 T/2000 Edwards 6,622,047 9, 2003 Barrett et al. 6,102.922 8, 2000 Jakobsson et al. 6,631,296 10, 2003 Parramon et al. 6,104,955 8, 2000 Bourgeois 6,635,014 10, 2003 Starkweather et al. 6,104,956 8, 2000 Naritoku et al. 6,647.296 11/2003 Fischell et al. 6,109,269 8, 2000 Rise et al. 6,650,943 11/2003 Whitehurst et al. 6,115,635 9, 2000 Bourgeois 6,656,125 12, 2003 Misczynski et al. 6,128,538 10, 2000 Fischell et al. 6,662,052 12, 2003 Sarwal et al. 6,129,685 10, 2000 Howard, III 6,671,555 12, 2003 Gielen et al. 6,161,044 12, 2000 Silverstone 6,671,556 12, 2003 Osorio et al. 6,167,311 12, 2000 Rezai 6,684, 104 1, 2004 Gordon et al. 6,178,349 1, 2001 Kieval 6,684, 105 1, 2004 Cohen et al. 6, 181965 1, 2001 Loeb et al. 6,694,191 2, 2004 Starkweather et al. 6,205.359 3, 2001 Boveja 6,721,603 4, 2004 Zabara et al. 6,216,039 4, 2001 Bourgeois 6,735,474 5, 2004 Loeb et al. 6,233,488 5, 2001 Hess 6,735,475 5, 2004 Whitehurst et al. 6,238,423 5, 2001 Bardy 6,754,536 6, 2004 Swoyer et al. 6,240,316 5, 2001 Richmond et al. 6,760,626 T/2004 Boveja US 7,657,310 B2 Page 3 6,768,969 B1 7/2004 Nikitin et al. 2005/0065574 A1 3/2005 Rezai .......................... 607,45 6,775,573 B2 8, 2004 Schuler et al. 2005, OO65575 A1 3, 2005 Dobak 6,788,970 B1 9, 2004 Park et al. 2005.00757O2 A1 4/2005 Shafer 6,788.975 B1 9, 2004 Whitehurst et al. 2005/01 19703 A1 6/2005 DiLorenzo 6,793,670 B2 9, 2004 Osorio et al.
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