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Pharmacy Research Reports PHARMACEUTICAL SERVICES PROGRAMME MINISTRY OF HEALTH MALAYSIA VOLUME 1 2018 PHARMACY RESEARCH REPORTS PHARMACY RESEARCH REPORTS VOLUME 1 2018 The Pharmacy Research Reports is published by the Pharmaceutical Services Programme, Ministry of Health Malaysia (MOH). This is an International Standard Serial Number (ISSN) registered publication with the National Bibliography Centre, National Library of Malaysia. This document contains compilation of research articles of pharmacy related researches conducted in the MOH by the MOH pharmacists and other professionals. All researches included in this report were registered with the National Medical Research Register (NMRR) and ethics approvals had been obtained from the Medical Research and Ethics Committee (MREC) if required. The opinions expressed in all articles, including the Editorials, are the authors’ own and do not necessarily reflect the view of the Pharmaceutical Services Programme, Ministry of Health Malaysia. December 2018 © Ministry of Health Malaysia Editorial Address: Editor in Chief Pharmacy Research Reports Pharmacy Policy and Strategic Planning Division Pharmaceutical Services Programme Ministry of Health Malaysia Lot 36, Jalan Universiti, 46200 Petaling Jaya, Selangor, Malaysia Tel. : (603) 7841 3200 Fax : (603) 7968 2222 Website : https://www.pharmacy.gov.my PHARMACY RESEARCH REPORTS VOLUME 1 2018 EDITORIAL BOARD Advisors Dr Hasenah Ali & MOH Pharmacy Research and Development (R&D) Committee Editor in Chief Dr. Abdul Haniff Mohd Yahaya Reviews Editor Dr. Azuana Ramli Mary Chok Chiew Fong Ho See Wan Chan Lai Yue Nurhafiza Md Hamzah Secretariat Dr. Azuana Ramli Chan Pui Lim 3 Ho See Wan Safura Sa’ad Noor Atiqah Mat Yusoff 3 PHARMACY RESEARCH REPORTS | VOLUME 1 | 2018 MEMBERS OF THE MOH PHARMACY RESEARCH AND DEVELOPMENT (R&D) COMMITTEE 2017-2018 Chairperson Dr. Hasenah binti Ali Director of Pharmacy Policy and Strategic Planning Division Secretary Dr. Azuana binti Ramli Deputy Director, Pharmacy Policy and Strategic Planning Division Committee Members Mazlan bin Ismail Norazlin binti Abd. Kadir Pharmacy Enforcement Division Pharmacy Practice and Development Division Ida Syazrina binti Ibrahim Bibi Faridha binti Mohd Salleh National Pharmaceutical Regulatory Agency Pharmacy Policy and Strategic Planning Division Dzafarullah bin Daud Zahrina binti Abdul Kadir Pharmacy Board Malaysia Johor State Health Department Norazila binti Abd. Ghani Nazmi Liana binti Azmi Hospital Sultanah Bahiyah, Kedah Hospital Raja Perempuan Zainab II, Kelantan Saidatul Raihan binti Ibrahim Basariah binti Naina Hospital Melaka Hospital Tuanku Ja’afar, Negeri Sembilan Dr. Jannatul Ain binti Jamal Rohaizan binti Mohd Hanafiah Hospital Tengku Ampuan Afzan, Pahang Pulau Pinang State Health Department Dr. Abdul Haniff bin Mohd Yahaya Hazlin Syafinar binti Hussein Hospital Teluk Intan, Perak Perlis State Health Department Norharlina binti Sulaiman Aishah binti Hamzah Klang District Health Office, Selangor Hospital Hulu Terengganu, Terengganu Jerry Liew Ee Siung Ridhwan bin Abdullah Hospital Queen Elizabeth, Sabah Hospital Sentosa, Sarawak Soo Bee Kuan Yuzlina binti Mohd Yahaya Labuan State Health Department Hospital Rehabilitasi Cheras, Kuala Lumpur Dr. Norkasihan binti Ibrahim Azmi Nor Mohd Farez bin Ahmat Hospital Kuala Lumpur National Cancer Institute Secretariat Chan Pui Lim Mary Chok Chiew Fong Pharmacy Policy and Strategic Planning Division Pharmacy Policy and Strategic Planning Division 4 Ho See Wan Chan Lai Yue Pharmacy Policy and Strategic Planning Division Pharmacy Policy and Strategic Planning Division Safura binti Sa’ad Noor Atiqah binti Mat Yusoff Pharmacy Policy and Strategic Planning Division Pharmacy Policy and Strategic Planning Division Mohd Faiz bin Abdul Manan Pharmacy Policy and Strategic Planning Division 4 PHARMACY RESEARCH REPORTS | VOLUME 1 | 2018 FOREWORD Senior Director of Pharmaceutical Services It is with great pleasure that I introduce you to the first Pharmacy Research Reports published by the Pharmaceutical Services Programme. This report, the Pharmacy Research Reports Volume 1 2018, marks a milestone in our effort to document research findings conducted by the pharmacists in the Ministry of Health. This sharing of information is hoped to enable pharmacists in the country to utilise available research findings in their practices and to encourage more pharmacists to embark in pharmacy research. I would like to take this opportunity to thank all the researchers who have agreed to share their research findings through this inaugural report for the benefit of the pharmacy services. It demonstrates their hard work and dedication in striving for improvements. Despite their challenging and busy schedule they are willing to take the time to document their research for the benefit of pharmacy services and the population as a whole. With this, I would like to express my gratitude for all the efforts put in by the Editor in Chief, the reviewers and the editorial committee members to make the first publication of the Pharmacy Research Reports a success. Thank you. 5 Dr. Ramli Bin Zainal, RPh. 1045 Senior Director of Pharmaceutical Services Ministry of Health Malaysia 5 PHARMACY RESEARCH REPORTS | VOLUME 1 | 2018 EDITORIAL From Research to Practice Abdul Haniff Mohd Yahaya Research is an essential part of pharmaceutical services and healthcare delivery. It is encouraging to note that the culture of conducting research is getting stronger among fellow pharmacists in the Ministry of Health Malaysia (MOH). Research is fundamental to generate evidences that support policy decision-making and improve health services. As part of the efforts to enhance research and knowledge sharing, as stipulated in the Pharmacy Programme Strategic Plan 2017-2020, we are honoured to present to all our readers the Pharmacy Research Reports Volume 1 2018. This report encompasses research findings in various areas such as quality use of medicines, impact of pharmacy services, policy research, clinical research, pharmacoepidemiology and drug safety. We believe that the documentation of research evidence is an important step to enable translation of research findings into policy and practice. This platform is also intended to introduce researchers from different fields and to gather researchers with similar interests to initiate bigger and more impactful research projects, avoiding duplicative efforts at different facilities. It is hoped that the research findings published are able to help policy decisions making and subsequently drive new policies for the continuous strengthening of the health system. 6 6 PHARMACY RESEARCH REPORTS | VOLUME 1 | 2018 CONTENTS page i. Foreword by the Senior Director of Pharmaceutical Services 5 ii. EDITORIAL 6 1. Availability of Essential Medicines in the Remote Public Health Facilities in Malaysia 8 Izzati Mohd Farok, Bibi Faridha Mohd Salleh, Lau Ling Wei, Ramli Zainal 2. Adverse Drug Reactions of Clozapine and Their Management in a Tertiary Care Hospital in 15 Kelantan Nazmi Liana Azmi, Fazlina Mohamed, Nurul Khairiyah Wanik, Chua Siew May, Nur ‘Izzati Ahmad Zawawi 3. A Prospective Study on Antibiotic De-escalation Practice in the Medical Wards of Penang 24 General Hospital Wong Kar Loon, Wong Mei Ling, Chong Zan Kai, Siva Malar Ganasen, Wan Sakinah Wan Hasbullah, Chee Sze Hui, Chow Ting Soo, Leong Kar Nim, Wong Peng Shyan, Ch’ng Wei Choong 4. The Impact of Epilepsy Review Service on Seizure Control in Primary Care 32 Wong Su Li, Cheang Ching Ye, Norharlina Sulaiman, Hanum Maisarah Abdul Rahman, Ng Kar Mun 5. Evaluation of Utilisation and Concordance to Guideline-recommended Statin Therapy at 42 Medical Outpatient Clinic, Hospital Kuala Krai Low Joo Zheng, Ahmad Salihin Abdullah, Nurul Azerah Idris, Siti Noriah Muhd Yuna, M. Irfan Ab Aziz 6. Retrospective Review of Postnatal Growth Rate of Premature Infants Receiving Early 52 Parenteral Nutrition in a Malaysian Tertiary Hospital Neonatal Intensive Care Unit Loo Jing Hean, Limata @ Monalita Binti Othman 7. Knowledge and Attitude on Safe Handling of Cytotoxic Agents among Healthcare Staff in 61 Tengku Ampuan Rahimah Hospital (HTAR), Klang Lee Jian Lynn, Tai Chu Hong, Lim Soon Seng, Keng Zhi Hong, Nur Syuhada Zainudin, Yeo Wei Yan, Lee Sheah Lin, Khairul Azrul Abdul Rahman 8. Scheduled Substances as a Cause Leading to Dangerous Drug Abuse 67 Zamrul Hisyam Noor, Ahmad Aizat Zaini, Mohd Hanif Mustafa 9. Study of Traditional and Complementary Medicine (TCM) Usage among Cancer Patients 78 Receiving Chemotherapy in Hospital Melaka 7 Wong Kuo Zang, Mastria Mohamed, Loh Wan Ting, Suhadah Ahad 10. Comparing the Glycaemic and Weight Control Effects of Basal-bolus and Premixed Insulin 87 Regimen among Patients with Type 2 Diabetes Mellitus in Johor Chong Men Yee 11. Patients’ Beliefs about Generic Medicines in the Outpatient Setting, Sibu Hospital 93 Chuo Sing Hong, Carmen Wong Jia Jia, Ling Mei Siew, Sia Khang Lin, Tiong Chang Hwa 12. Assessment of Public Knowledge and Perception towards Childhood Vaccination in Perlis, 104 Malaysia Wan Nor Amalina Zainun, Nuwairoh Nasir, Nur Iffah Iwani Ghazali, Tan Keh Ying 7 PHARMACY RESEARCH REPORTS | VOLUME 1 | 2018 Availability of Essential Medicines in the Remote Public Health Facilities in Malaysia Izzati Mohd Farok1, Bibi Faridha Mohd Salleh1, Lau Ling Wei1, Ramli Zainal2 1 Pharmacy Policy and Strategic Planning Division, Ministry of Health Malaysia 2 Pharmaceutical Services Programme, Ministry of Health Malaysia Abstract Introduction: Approximately one-third of the world population
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