CURRICULUM VITAE

Dr. Lyndon M. West Assistant Professor, Florida Atlantic University Department of Chemistry & Biochemistry Boca Raton, FL 33431

Phone: (561) 297-0939 Fax: (561) 297-2759 E-mail: [email protected] Webpage: http://westnatprodgroup.wordpress.com/dr-lyndon-west/

Nationality: New Zealand Date of Birth: 5 February 1975

a. Employment

2009- Assistant Professor, Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton Florida.

2006-2008 Assistant Professor, Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens.

2004-2005 Research Assistant Professor, Florida Atlantic University, Florida.

2003-2004: Senior Scientist, Sequoia Sciences, San Diego, California.

2001-2003: Postdoctoral Research Chemist, Scripps Institution of Oceanography (Dr. D. John Faulkner).

1997-98: Teaching Assistant (Physical Science), School of Chemical and Physical Sciences, Victoria University, Wellington.

b. Education

1997-2001: Ph.D. in Organic Chemistry, Victoria University of Wellington, New Zealand. (Supervisor Dr P. T. Northcote)

Thesis Title: Isolation of Biologically Active Secondary Metabolites from New Zealand Marine .

1996 Dec: B.Sc. Hons. in Chemistry, Victoria University Wellington, New Zealand. (Supervisor Dr P. T. Northcote)

Project Report: Analysis of Pateamine in the New Zealand Marine sp.

1993-1995: B.Sc. in Chemistry, Victoria University of Wellington, New Zealand.

c. Postdoctoral Experience

2001-2003: Postdoctoral Research Chemist at SCRIPPS Institution of Oceanography (Dr. D. John Faulkner)

d. Courses Taught at FAU and a Brief Course Description

CHM 2211: Organic Chemistry II, Fall 2010, Spring, Fall 2011, Spring 2012 (Instructor)

A more advanced study of different types of organic (carbon-based) compounds, their nomenclature, structure, identification, chemical behavior and reaction mechanisms. This course builds directly on material from Organic I Chemistry.

CHM 4139L: Bioanalytical Instrumentation Laboratory Spring, 2011, Spring 2012 (Co- Instructor)

Introduction to instrumental analysis. The objective of this course is to get a basic understanding of quantitative instrumental analysis that involves electromagnetic radiation, spectroscopy, mass spectrometry, electrochemistry, and chromatography.

CHM 2210: Organic Chemistry I, Spring 2010 (Instructor)

This course introduces students with a description of different types of organic (carbon-based) compounds, their nomenclature, structure, identification, chemical behavior, reactivity and reaction mechanisms.

CHM 6157: Instrumentation, Fall 2009 (Co-Instructor)

By the end of this course, students should be able to understand the operation and theory of most of the instrumental methods currently used in our department’s research projects and how to apply such methods to solve complex chemical and biochemical problems.

CHM 6730, Synthesis and Characterization, Spring 2009 (Co-Instructor)

Methods used by chemists to structurally characterize small organic molecules will be discussed. Emphasis will be placed on modern MS and NMR methods (1H- and 13C-NMR, DEPT, COSY, NOESY, HMBC, HMQC). The material will be presented using a standard lecture format as well as problem solving sessions in small groups.

e. Scholarly Activities- Summary of Research Areas, Publications, Abstracts, Presentations at Scientific Meetings, Other Scholarly/Professional Contributions

Summary of Research Area

My research at FAU focuses on the isolation and structural elucidation of biologically active natural products from marine organisms, in addition to the development of new methodology for natural products chemistry to accelerate the discovery of drug leads.

Journal Publications

• Duckworth, A. R.; West, L. M.; Vansach, T.; Stubler, A.; Hardt, M. Effects of water temperature and pH on growth and metabolite biosynthesis of coral reef sponges Mar. Ecol. Prog. Ser. 2012, 462, 67-77. • Meginley, R. J.; Gupta P.; Schulz T. C.; McLean, A. B.; Robins, A. J.; West L. M. Briareolate Esters from the Gorgonian Briareum asbestinum.” Marine Drugs 2012, 10, 1662-1670. • Gupta P.; Sharma, U. West, L. M. Bicyclic C21 Terpenoids from the Marine Sponge Clathria compressa. J. Nat. Prod. 2012, 75 (6), 1223-1227. • Gupta, P.; Sharma, U.; Schulz, T. C.; Sherrer, E. S.; McLean, A. B.; Robins, A. J.; West, L. M. Diterpenoid Containing a Reversible “Spring-Loaded” (E,Z)-Dieneone Michael Acceptor Organic Letters 2011, 13 (15), 3920-3923. • Zheng, B.; West, L. M. Estimating the Lipophilicity of Natural Products using a Polymeric Reversed Phase HPLC Method. J. Liq. Chromatogr. Related Technol. 2010, 33, 118-132. • Singh, A. J.; Xu, C.-X.; Xu, X.; West, L. M.; Wilmes, A.; Chan, A.; Hamel, E.; Miller, J. H.; Northcote, P. T.; Ghosh, A. K., Peloruside B, A Potent Antitumor Macrolide from the New Zealand Marine Sponge Mycale hentscheli: Isolation, Structure, Total Synthesis, and Bioactivity. J. Org. Chem, 2010, 75, (1), 2-10. • Araki, T.; Matsunaga S.; Nakao, Y.; Furihata, K.; West, L. M.; Faulkner, D. J.; Fusetani, N. Koshikamide B, a Cytotoxic Peptide Lactone from a Marine Sponge Theonella sp. J. Org. Chem. 2008, 73, 7889-7894. • West, L. M.; Faulkner D. J. Acanthosulfate, a Sulfated Hydroxyhydroquinone Sesterterpene form the Sponge Acanthodendrilla. J. Nat. Prod. 2008, 71, 269 -271. • West, L. M.; Faulkner D. J. Hexaprenoid hydroquinones from the Sponge Haliclona (aka Adocia) sp. J. Nat. Prod. 2006, 69, 1001-1004. • Page M. J.; West, L. M.; Northcote P. T.; Kelly-Shanks M. Spatial and Temporal Variability of Cytotoxic Metabolites in Populations of the New Zealand Sponge Mycale hentscheli (: ) J. Chem Ecology, Chem. Ecology 2005, 31, 1161-1174. • Fenical W.; Jensen P. R.; Kauffman C.; Mayhead S. L.; Faulkner D. J.; Sincich, C.; Rama Rao M.; Kantorowski E. J.; West L. M.; Strangman W. K.; Shimizu Y.; Li B.; Thammana S.; Drainville K.; Davies-Coleman M. T.; Kramer R. A.; Fairchild C. R.; Rose W. C.; Wild R. C.; Vite C. D.; Peterson R. W. New Anticancer Drugs from Cultured and Collected Marine Organisms. Pharm. Biology 2003, 41, 6-14. • Meragelman K. M.; West, L. M.; Northcote P. T.; Pannell, L. K.; McKee T. C.; Boyd, M. R. Unusual Sulfamate Indoles and a Novel Indolo[3,2-a]carbazole from Ancorina sp. J. Org. Chem. 2002, 67, 6671-6677. • Hood K. A.; West L. M.; Rouwé, B.; Northcote P. T.; Berridge M. V.; Miller J. H. Peloruside A, a New Class of Anti-Mitotic Agent with Paclitaxel-Like Microtubule-Stabilizing Activity. Cancer Res. 2002, 62, 3356-3360. • Hood K. A.; Bäckström, B. T, West L. M.; Northcote, P. T.; Berridge, M. V.; Miller, J. H. The Novel Cytotoxic Sponge Metabolite Peloruside A, Structurally Similar to Bryostatin-1, has Unique Bioactivity Independent of Protein Kinase C. Anti-Cancer Drug Design 2001, 16, 155- 166. • Hood K. A.; West L. M.; Northcote P. T. Berridge M. V.; Miller J. H. Induction of Apoptosis by the Marine Sponge (Mycale) Metabolites, Mycalamide A and Pateamine. Apoptosis 2001, 6, 207-219. • West L.M.; Northcote P. T.; Hood K. A.; Miller J. H.; Page, M. J. Mycalamide D, a new Cytotoxic Amide from the New Zealand Marine Sponge Mycale Species. J. Nat. Prod. 2000, 63, 707-709. • West L. M.; Northcote, P. T.; Battershill C. N. Peloruside A: A Potent Cytotoxic Macrolide Isolated from the New Zealand Marine Sponge Mycale sp. J. Org. Chem. 2000, 65, 445-449. • West L. M.; Northcote, P. T.; Battershill C. N. Two New Clerodane diterpenes from the New Zealand Marine Sponge Raspailia sp. Aust. J. Chem. 1998, 51, 1097-1101.

Presentations at Scientific Meetings

2012 August: NIH Program Project Grant ‘basic biology of human pluripotent stem cells” Scientific Retreat, Ritz-Carlton, Reynolds Plantation, GA. Presented a talk entitled:

Discovery of marine natural products that impact human embryonic stem cell growth.

2012 July: 2012 International Congress on Natural Products Research, Global Change, Natural Products and Human Health.

Cornoside A, a new monoterpenoid glucosude with an unusual skeleton from Cornus controvers. Yangqing He, Jiangnan Peng, Lyndon West and Mark Hamann.

2011 August: NIH Program Project Grant ‘basic biology of human pluripotent stem cells” Scientific Retreat, Ritz-Carlton, Reynolds Plantation, GA. Presented a talk entitled:

Identification of marine natural products that impact human embryonic stem cell growth.

2011 April: Florida Atlantic University’s 2nd Annual Graduate Student Research Day, Boca Raton, Florida

Climate change impacts on the secondary metabolite production in Caribbean coral reef sponges. Tifanie Vansach, Alan Duckworth, Marah Hardt, Amber Stubler, and Lyndon West

Novel Compounds Isolated from the Marine Sponge Clathria sp. Rolando Rueda de Leon, Prasoon Gupta and Lyndon M. West.

2011 March: The Florida Atlantic University College of Science Research Day, Boca Raton, Florida.

Climate change impacts on the secondary metabolite production in Caribbean coral reef sponges. Tifanie Vansach, Alan Duckworth, Marah Hardt, Amber Stubler, and Lyndon West

2010 December: The 2010 International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii.

Climate change impacts on the secondary metabolite production in Caribbean coral reef sponges. Tifanie Vansach, Alan Duckworth, Marah Hardt, Amber Stubler, and Lyndon West.

2010 September: VIII World Sponge Conference 2010, Girona, Spain

Climate change impacts on coral reef sponges. Duckworth, A. R.; West, L. M.; Vansach, T.; Stubler, A.; Hardt, M.

2010 August: NIH Program Project Grant ‘basic biology of human pluripotent stem cells” Scientific Retreat, Ritz-Carlton, Reynolds Plantation, GA Presented a talk entitled:

Identification of marine natural products that impact human embryonic stem cell growth.

2010 July: 51st Annual Meeting of the American Society of Pharmacognosy, St Petersburg Beach, Florida.

Climate change impacts on the metabolite concentration and composition of the Caribbean coral reef sponge Ectyoplasia ferox. Tifanie Vansach, Alan Duckworth, Marah Hardt, Amber Stubler, and Lyndon West.

Cytotoxic Activity Of Polyhydroxylated Sterols Isolated From Dysidea Etheria Against Human Embryonic Stem Cells. Prasoon Gupta, Thomas C. Schulz, Eric S. Sherrer, Amanda B. McLean, Allan J. Robins, and Lyndon M. West

Optimization Of Extraction, Loading, And Elution Of Marine Invertebrate Crude Extracts Using Polymeric Resin. Rolando Rueda de Leon and Lyndon M. West.

2009 July: 50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, Hawaii.

Cytotoxic Diterpenes from Pseudopterogorgia elisabethae. Maia S. Mukherjee, Prasoon Gupta, Lyndon M. West.

2008 February: Gordon Research Conference on Marine Natural Products Ventura, California.

2008 February: Contribution on the role of University of Georgia to the progress of pharmacognosy for the 50th Anniversary of the ASP University of Georgia in the section on "Pharmacognosy in Action".

2007 October: Invited speaker at the 41st Annual Western Regional Meeting in San Diego. Solid-Phase Extraction-HPLC Method for the Production of a Marine Natural Products Library for High-Throughput Screening.

2007 July: NIH Molecular Libraries Screening Center Network (MLSCN) Steering Committee Meeting in Washington, DC. Presented a talk entitled "Generation of a Marine Natural Products Library for High-Throughput Screening”.

2007 July: NIH Molecular Libraries Screening Center Network (MLSCN) Steering Committee Meeting in Washington, DC. Presented a poster entitled "Marine Natural Products Chemistry: High-Throughput Identification of Biological Probes”.

f. Invited Seminars Given at Universities

2010 March Department of Biological Sciences, Florida Atlantic University. Integrative Biology Annual Ph.D. Retreat. Discovery of Bioactive Marine Natural Products.

2009 October Department of Chemistry & Biochemistry at Florida Atlantic University. Seminar Series: Identification of Marine Natural Products that Impact Human Embryonic Stem Cell Growth.

g. Research/Educational Grants Received

Effects of Water Temperature and pH on the Metabolite Biosynthesis of Coral Reef Algae. Florida Atlantic University Climate Change Initiative L. West (PI) 01/01/2012 - 12/31/2012 $ 3,300

The Discovery of New Anticancer Drugs from Marine Organisms American Cancer Society Seed money for Research L. West (Co-PI) 01/01/2011 - 12/31/2012 $ 20,000

Isolation of Biologically Active Compounds from Marine Invertebrates. Florida Institute of Oceanography L. West (Co-PI) 5/9/2010 $ 36,000

The Development of High-Throughput Screening Technologies for hESCs. National Institutes of Health - RFA-GM-08-003 L. West (Co-PI) 08/01/2008 - 7/31/2013 $ 368,750

Generation of “Drug-like” Marine Natural Product Library (Administrative supplement) National Institutes of Health - RFA-RM-06-003 L. West (PI) 9/1/2008 - 8/31/2009 $ 193,123

Generation of “Drug-like” Marine Natural Product Library National Institutes of Health - RFA-RM-06-003 L. West (PI) 9/1/2006 - 8/31/2011 $ 907,625

Identification of New Anti-Cancer Drugs from Marine Organisms Georgia Cancer Coalition L. West (PI) 11/1/2006 – 11/1/2008 $ 55,000

Biomedical Potential of Marine Natural Products University of Georgia Faculty Research Grant L. West (PI) 12/1/2006 – 12/1/2007 $ 6,200

Chemical Variation in Marine Cyanobacteria for Drug Discovery Florida Sea Grant L. West (Co-PI) 2006 – 2008 $ 75,000

A Novel Approach to the Identification of Biologically Active Marine Natural Products American Society of Pharmacognosy L. West (PI) 2005 – 2006 $ 5,000

Isolation of Biologically Active Compounds from Marine Invertebrates. Florida Institute of Oceanography L. West (PI) 2005 $ 23,000

h. Mentoring and Training - Graduate Students, Undergraduates, Pharm.D. Students, Postdoctoral Associates, Technicians, and Others

Master Students

Rian Meginley (Fall 2009 - present) Melody Rondeau (Fall 2009 – Summer 2012) Graduated summer 2012 Rolando Rueda de Leon (Fall 2009 – Summer 2012) Graduated summer 2012 Ph.D. Students

Andrew Hall (Fall 2009 - present) Yangqing He (Fall 2010 - present) Admitted to candidacy Theresa Meickle (Spring 2010 – Fall 2011) Graduated Fall 2011 Tifanie Vansach (Spring 2010 - present) Long Zhang (Fall 2009 - present)

Undergraduate Students:

Derek Mitchell (Summer 2009 and Fall 2009) Rishad Ahmed (Spring 2010) Allison Garnsey (Fall 2009 and Spring 2010) Ricardo Flefil (Fall 2009 and Spring 2010) Cherly Philippeaux (Spring 2010) Richard Lantz (Fall 2010) Yogesh Paghdar (Fall 2010) Scarlett Somarriba (Fall 2010) Deborah Stewart (Summer 2011) Andrew Sheffler (Spring 2012) Geeta Anjali Langham (Fall 2011) Jamie Ulmer (Summer 2010) Cibele Almada (Summer 2010) Mayelin Alfonso (Summer 2010) Allison Griffin (Fall 2011) Kedly Lejulus (Fall 2011)

Serve(d) on Graduate Student Thesis Committee for:

Maria Rodriguez (Fall 2010 - present) Timothy Logue (Fall 2011 - present) Mari Heghinian (Fall 2009 - present) Jing Ye (Fall 2009 – Fall 2011) Theresa Meickle (Spring 2009 – Fall 2009)

Postdoctoral fellows: Prasoon Gupta (December 2008 – January 2012) Upasana Sharma (December 2008 – July 2010)

i. Service Contributions-Department, College, University, Profession and Public Service

Department Department Chemistry and Biochemistry Curriculum Committee. Department Chemistry and Biochemistry NMR Facilities Operations Manager. Department Chemistry and Biochemistry Instrumentation Committee.

University

Florida Atlantic University Diving and Boating Safety Committee.

Editorships and Editorial Boards

Journal of Natural Products ASSAY and Drug Development Technologies Journal of Chromatography B Marine Drugs

k. Other Relevant Contributions

NIH Study Section: NIH Roadmap Special Emphasis Panel: ZRG1 BCNB-R 50R May 2008, Washington DC.

Special Awards Judge (American Society of Pharmacognosy): The Intel International Science and Engineering Fair 2008 Atlanta, GA.

NSF Grant Reviewer