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Curriculum Vitae CURRICULUM VITAE Dr. Lyndon M. West Assistant Professor, Florida Atlantic University Department of Chemistry & Biochemistry Boca Raton, FL 33431 Phone: (561) 297-0939 Fax: (561) 297-2759 E-mail: [email protected] Webpage: http://westnatprodgroup.wordpress.com/dr-lyndon-west/ Nationality: New Zealand Date of Birth: 5 February 1975 a. Employment 2009- Assistant Professor, Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton Florida. 2006-2008 Assistant Professor, Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens. 2004-2005 Research Assistant Professor, Florida Atlantic University, Florida. 2003-2004: Senior Scientist, Sequoia Sciences, San Diego, California. 2001-2003: Postdoctoral Research Chemist, Scripps Institution of Oceanography (Dr. D. John Faulkner). 1997-98: Teaching Assistant (Physical Science), School of Chemical and Physical Sciences, Victoria University, Wellington. b. Education 1997-2001: Ph.D. in Organic Chemistry, Victoria University of Wellington, New Zealand. (Supervisor Dr P. T. Northcote) Thesis Title: Isolation of Biologically Active Secondary Metabolites from New Zealand Marine Sponges. 1996 Dec: B.Sc. Hons. in Chemistry, Victoria University Wellington, New Zealand. (Supervisor Dr P. T. Northcote) Project Report: Analysis of Pateamine in the New Zealand Marine Sponge Mycale sp. 1993-1995: B.Sc. in Chemistry, Victoria University of Wellington, New Zealand. c. Postdoctoral Experience 2001-2003: Postdoctoral Research Chemist at SCRIPPS Institution of Oceanography (Dr. D. John Faulkner) d. Courses Taught at FAU and a Brief Course Description CHM 2211: Organic Chemistry II, Fall 2010, Spring, Fall 2011, Spring 2012 (Instructor) A more advanced study of different types of organic (carbon-based) compounds, their nomenclature, structure, identification, chemical behavior and reaction mechanisms. This course builds directly on material from Organic I Chemistry. CHM 4139L: Bioanalytical Instrumentation Laboratory Spring, 2011, Spring 2012 (Co- Instructor) Introduction to instrumental analysis. The objective of this course is to get a basic understanding of quantitative instrumental analysis that involves electromagnetic radiation, spectroscopy, mass spectrometry, electrochemistry, and chromatography. CHM 2210: Organic Chemistry I, Spring 2010 (Instructor) This course introduces students with a description of different types of organic (carbon-based) compounds, their nomenclature, structure, identification, chemical behavior, reactivity and reaction mechanisms. CHM 6157: Instrumentation, Fall 2009 (Co-Instructor) By the end of this course, students should be able to understand the operation and theory of most of the instrumental methods currently used in our department’s research projects and how to apply such methods to solve complex chemical and biochemical problems. CHM 6730, Synthesis and Characterization, Spring 2009 (Co-Instructor) Methods used by chemists to structurally characterize small organic molecules will be discussed. Emphasis will be placed on modern MS and NMR methods (1H- and 13C-NMR, DEPT, COSY, NOESY, HMBC, HMQC). The material will be presented using a standard lecture format as well as problem solving sessions in small groups. e. Scholarly Activities- Summary of Research Areas, Publications, Abstracts, Presentations at Scientific Meetings, Other Scholarly/Professional Contributions Summary of Research Area My research at FAU focuses on the isolation and structural elucidation of biologically active natural products from marine organisms, in addition to the development of new methodology for natural products chemistry to accelerate the discovery of drug leads. Journal Publications • Duckworth, A. R.; West, L. M.; Vansach, T.; Stubler, A.; Hardt, M. Effects of water temperature and pH on growth and metabolite biosynthesis of coral reef sponges Mar. Ecol. Prog. Ser. 2012, 462, 67-77. • Meginley, R. J.; Gupta P.; Schulz T. C.; McLean, A. B.; Robins, A. J.; West L. M. Briareolate Esters from the Gorgonian Briareum asbestinum.” Marine Drugs 2012, 10, 1662-1670. • Gupta P.; Sharma, U. West, L. M. Bicyclic C21 Terpenoids from the Marine Sponge Clathria compressa. J. Nat. Prod. 2012, 75 (6), 1223-1227. • Gupta, P.; Sharma, U.; Schulz, T. C.; Sherrer, E. S.; McLean, A. B.; Robins, A. J.; West, L. M. Diterpenoid Containing a Reversible “Spring-Loaded” (E,Z)-Dieneone Michael Acceptor Organic Letters 2011, 13 (15), 3920-3923. • Zheng, B.; West, L. M. Estimating the Lipophilicity of Natural Products using a Polymeric Reversed Phase HPLC Method. J. Liq. Chromatogr. Related Technol. 2010, 33, 118-132. • Singh, A. J.; Xu, C.-X.; Xu, X.; West, L. M.; Wilmes, A.; Chan, A.; Hamel, E.; Miller, J. H.; Northcote, P. T.; Ghosh, A. K., Peloruside B, A Potent Antitumor Macrolide from the New Zealand Marine Sponge Mycale hentscheli: Isolation, Structure, Total Synthesis, and Bioactivity. J. Org. Chem, 2010, 75, (1), 2-10. • Araki, T.; Matsunaga S.; Nakao, Y.; Furihata, K.; West, L. M.; Faulkner, D. J.; Fusetani, N. Koshikamide B, a Cytotoxic Peptide Lactone from a Marine Sponge Theonella sp. J. Org. Chem. 2008, 73, 7889-7894. • West, L. M.; Faulkner D. J. Acanthosulfate, a Sulfated Hydroxyhydroquinone Sesterterpene form the Sponge Acanthodendrilla. J. Nat. Prod. 2008, 71, 269 -271. • West, L. M.; Faulkner D. J. Hexaprenoid hydroquinones from the Sponge Haliclona (aka Adocia) sp. J. Nat. Prod. 2006, 69, 1001-1004. • Page M. J.; West, L. M.; Northcote P. T.; Kelly-Shanks M. Spatial and Temporal Variability of Cytotoxic Metabolites in Populations of the New Zealand Sponge Mycale hentscheli (Poecilosclerida: Mycalidae) J. Chem Ecology, Chem. Ecology 2005, 31, 1161-1174. • Fenical W.; Jensen P. R.; Kauffman C.; Mayhead S. L.; Faulkner D. J.; Sincich, C.; Rama Rao M.; Kantorowski E. J.; West L. M.; Strangman W. K.; Shimizu Y.; Li B.; Thammana S.; Drainville K.; Davies-Coleman M. T.; Kramer R. A.; Fairchild C. R.; Rose W. C.; Wild R. C.; Vite C. D.; Peterson R. W. New Anticancer Drugs from Cultured and Collected Marine Organisms. Pharm. Biology 2003, 41, 6-14. • Meragelman K. M.; West, L. M.; Northcote P. T.; Pannell, L. K.; McKee T. C.; Boyd, M. R. Unusual Sulfamate Indoles and a Novel Indolo[3,2-a]carbazole from Ancorina sp. J. Org. Chem. 2002, 67, 6671-6677. • Hood K. A.; West L. M.; Rouwé, B.; Northcote P. T.; Berridge M. V.; Miller J. H. Peloruside A, a New Class of Anti-Mitotic Agent with Paclitaxel-Like Microtubule-Stabilizing Activity. Cancer Res. 2002, 62, 3356-3360. • Hood K. A.; Bäckström, B. T, West L. M.; Northcote, P. T.; Berridge, M. V.; Miller, J. H. The Novel Cytotoxic Sponge Metabolite Peloruside A, Structurally Similar to Bryostatin-1, has Unique Bioactivity Independent of Protein Kinase C. Anti-Cancer Drug Design 2001, 16, 155- 166. • Hood K. A.; West L. M.; Northcote P. T. Berridge M. V.; Miller J. H. Induction of Apoptosis by the Marine Sponge (Mycale) Metabolites, Mycalamide A and Pateamine. Apoptosis 2001, 6, 207-219. • West L.M.; Northcote P. T.; Hood K. A.; Miller J. H.; Page, M. J. Mycalamide D, a new Cytotoxic Amide from the New Zealand Marine Sponge Mycale Species. J. Nat. Prod. 2000, 63, 707-709. • West L. M.; Northcote, P. T.; Battershill C. N. Peloruside A: A Potent Cytotoxic Macrolide Isolated from the New Zealand Marine Sponge Mycale sp. J. Org. Chem. 2000, 65, 445-449. • West L. M.; Northcote, P. T.; Battershill C. N. Two New Clerodane diterpenes from the New Zealand Marine Sponge Raspailia sp. Aust. J. Chem. 1998, 51, 1097-1101. Presentations at Scientific Meetings 2012 August: NIH Program Project Grant ‘basic biology of human pluripotent stem cells” Scientific Retreat, Ritz-Carlton, Reynolds Plantation, GA. Presented a talk entitled: Discovery of marine natural products that impact human embryonic stem cell growth. 2012 July: 2012 International Congress on Natural Products Research, Global Change, Natural Products and Human Health. Cornoside A, a new monoterpenoid glucosude with an unusual skeleton from Cornus controvers. Yangqing He, Jiangnan Peng, Lyndon West and Mark Hamann. 2011 August: NIH Program Project Grant ‘basic biology of human pluripotent stem cells” Scientific Retreat, Ritz-Carlton, Reynolds Plantation, GA. Presented a talk entitled: Identification of marine natural products that impact human embryonic stem cell growth. 2011 April: Florida Atlantic University’s 2nd Annual Graduate Student Research Day, Boca Raton, Florida Climate change impacts on the secondary metabolite production in Caribbean coral reef sponges. Tifanie Vansach, Alan Duckworth, Marah Hardt, Amber Stubler, and Lyndon West Novel Compounds Isolated from the Marine Sponge Clathria sp. Rolando Rueda de Leon, Prasoon Gupta and Lyndon M. West. 2011 March: The Florida Atlantic University College of Science Research Day, Boca Raton, Florida. Climate change impacts on the secondary metabolite production in Caribbean coral reef sponges. Tifanie Vansach, Alan Duckworth, Marah Hardt, Amber Stubler, and Lyndon West 2010 December: The 2010 International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii. Climate change impacts on the secondary metabolite production in Caribbean coral reef sponges. Tifanie Vansach, Alan Duckworth, Marah Hardt, Amber Stubler, and Lyndon West. 2010 September: VIII World Sponge Conference 2010, Girona, Spain Climate change impacts on coral reef sponges. Duckworth, A. R.; West, L. M.; Vansach, T.; Stubler, A.; Hardt, M. 2010 August: NIH Program Project Grant ‘basic biology of human pluripotent stem cells” Scientific Retreat,
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