DOCSLIB.ORG

Safety Data Sheet: Chlorobenzene

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Safety Data Sheet: Chlorobenzene safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU Chlorobenzene ≥99,5 %, for synthesis article number: KK01 date of compilation: 2016-08-18 Version: 1.0 en SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifier Identification of the substance Chlorobenzene Article number KK01 Registration number (REACH) This information is not available. Index No 602-033-00-1 EC number 203-628-5 CAS number 108-90-7 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses: laboratory chemical 1.3 Details of the supplier of the safety data sheet Carl Roth GmbH + Co KG Schoemperlenstr. 3-5 D-76185 Karlsruhe Germany Telephone: +49 (0) 721 - 56 06 0 Telefax: +49 (0) 721 - 56 06 149 e-mail: [email protected] Website: www.carlroth.de Competent person responsible for the safety data : Department Health, Safety and Environment sheet e-mail (competent person) : [email protected] 1.4 Emergency telephone number Emergency information service Poison Centre Munich: +49/(0)89 19240 SECTION 2: Hazards identification 2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 (CLP) Classification acc. to GHS Section Hazard class Hazard class and cat- Hazard egory state- ment 2.6 flammable liquid (Flam. Liq. 3) H226 3.1I acute toxicity (inhal.) (Acute Tox. 4) H332 3.2 skin corrosion/irritation (Skin Irrit. 2) H315 4.1C hazardous to the aquatic environment - chronic hazard (Aquatic Chronic 2) H411 United Kingdom (en) Page 1 / 15 safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU Chlorobenzene ≥99,5 %, for synthesis article number: KK01 Remarks For full text of Hazard- and EU Hazard-statements: see SECTION 16. 2.2 Label elements Labelling according to Regulation (EC) No 1272/2008 (CLP) Signal word Warning Pictograms Hazard statements H226 Flammable liquid and vapour. H315 Causes skin irritation. H332 Harmful if inhaled. H411 Toxic to aquatic life with long lasting effects. Precautionary statements Precautionary statements - prevention P210 Keep away from heat. No smoking. P280 Wear protective gloves/eye protection. Precautionary statements - response P303+P361+P353 IF ON SKIN (or hair): take off immediately all contaminated clothing. Rinse skin with water/shower. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor if you feel unwell. P332+P313 If skin irritation occurs: Get medical advice/attention. Labelling of packages where the contents do not exceed 125 ml Signal word: Warning Symbol(s) 2.3 Other hazards There is no additional information. United Kingdom (en) Page 2 / 15 safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU Chlorobenzene ≥99,5 %, for synthesis article number: KK01 SECTION 3: Composition/information on ingredients 3.1 Substances Name of substance Chlorobenzene Index No 602-033-00-1 EC number 203-628-5 CAS number 108-90-7 Molecular formula C6H5Cl g Molar mass 112,6 /mol SECTION 4: First aid measures 4.1 Description of first aid measures General notes Take off contaminated clothing. Following inhalation Provide fresh air. In all cases of doubt, or when symptoms persist, seek medical advice. Following skin contact Rinse skin with water/shower. In case of skin irritation, consult a physician. Following eye contact Rinse cautiously with water for several minutes. In all cases of doubt, or when symptoms persist, seek medical advice. Following ingestion Observe aspiration hazard if vomiting occurs. 4.2 Most important symptoms and effects, both acute and delayed Irritation, Localised redness, oedema, pruritis and/or pain, Malaise, Gastrointestinal complaints, Vomiting, Narcotic effects, Headaches and dizziness may occur, proceeding to fainting or uncon- sciousness 4.3 Indication of any immediate medical attention and special treatment needed none United Kingdom (en) Page 3 / 15 safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU Chlorobenzene ≥99,5 %, for synthesis article number: KK01 SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Co-ordinate fire-fighting measures to the fire surroundings water spray, foam, dry extinguishing powder, carbon dioxide (CO2) Unsuitable extinguishing media water jet 5.2 Special hazards arising from the substance or mixture Combustible. Vapours are heavier than air, spread along floors and form explosive mixtures with air. Vapours can form explosive mixtures with air. Hazardous combustion products In case of fire may be liberated: carbon monoxide (CO), carbon dioxide (CO2), hydrogen chloride (HCl), phosgene 5.3 Advice for firefighters Do not allow firefighting water to enter drains or water courses. Fight fire with normal precautions from a reasonable distance. Wear self-contained breathing apparatus. Special protective equipment for firefighters Protective clothing against liquid and gaseous chemicals, including liquid aerosols and solid particles. SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures For non-emergency personnel Wearing of suitable protective equipment (including personal protective equipment referred to under Section 8 of the safety data sheet) to prevent any contamination of skin, eyes and personal clothing. Avoid contact with skin, eyes and clothes. Do not breathe vapour/spray. Avoidance of ignition sources. 6.2 Environmental precautions Keep away from drains, surface and ground water. Retain contaminated washing water and dispose of it. Explosive properties. 6.3 Methods and material for containment and cleaning up Advices on how to contain a spill Covering of drains. Advices on how to clean up a spill Absorb with liquid-binding material (e.g. sand, diatomaceous earth, acid- or universal binding agents). Other information relating to spills and releases Place in appropriate containers for disposal. Ventilate affected area. Reference to other sections Hazardous combustion products: see section 5. Personal protective equipment: see section 8. Incompatible materials: see section 10. Disposal considerations: see section 13. United Kingdom (en) Page 4 / 15 safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU Chlorobenzene ≥99,5 %, for synthesis article number: KK01 SECTION 7: Handling and storage 7.1 Precautions for safe handling Provision of sufficient ventilation. • Measures to prevent fire as well as aerosol and dust generation Keep away from sources of ignition - No smoking. Take precautionary measures against static discharge. Advice on general occupational hygiene Wash hands before breaks and after work. Keep away from food, drink and animal feedingstuffs. When using do not smoke. 7.2 Conditions for safe storage, including any incompatibilities Keep container tightly closed. Incompatible substances or mixtures Observe hints for combined storage. Consideration of other advice Ground/bond container and receiving equipment. • Ventilation requirements Use local and general ventilation. • Specific designs for storage rooms or vessels Recommended storage temperature: 15 - 25 °C. 7.3 Specific end use(s) No information available. SECTION 8: Exposure controls/personal protection 8.1 Control parameters National limit values Occupational exposure limit values (Workplace Exposure Limits) Cou Name of agent CAS No Nota- Identifi- TWA TWA STEL STEL Source ntry tion er [pp [mg/m [pp [mg/m m] ³] m] ³] EU chlorobenzene 108-90-7 IOELV 5 23 15 70 2006/15/EC GB chlorobenzene 108-90-7 WEL 1 4,7 3 14 EH40/2005 Notation STEL Short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15- minute period unless otherwise specified TWA Time-weighted average (long-term exposure limit): measured or calculated in relation to a reference period of 8 hours time-weighted average Relevant DNELs/DMELs/PNECs and other threshold levels United Kingdom (en) Page 5 / 15 safety data sheet according to Regulation (EC) No. 1907/2006 (REACH), amended by 2015/830/EU Chlorobenzene ≥99,5 %, for synthesis article number: KK01 • human health values Endpoint Threshold Protection goal, Used in Exposure time level route of exposure DNEL 23 mg/m³ human, inhalatory worker (industry) chronic - systemic effects DNEL 70 mg/m³ human, inhalatory worker (industry) acute - systemic effects DNEL 5 mg/kg bw/day human, dermal worker (industry) chronic - systemic effects DNEL 15 mg/kg human, dermal worker (industry) acute - systemic effects bw/day • environmental values Endpoint Threshold level Environmental compartment Exposure time PNEC 0,032 mg/l freshwater short-term (single instance) PNEC 0,003 mg/l marine water short-term (single instance) PNEC 1,4 mg/l sewage treatment plant (STP) short-term (single instance) PNEC 0,922 mg/kg freshwater sediment short-term (single instance) PNEC 0,092 mg/kg marine sediment short-term (single instance) PNEC 0,166 mg/kg soil short-term (single instance) 8.2 Exposure controls Individual protection measures (personal protective equipment) Eye/face protection Use safety goggle with side protection. Skin protection • hand protection Wear suitable gloves. Chemical protection gloves are suitable, which are tested according to EN 374. For special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of
Load more

Recommended publications
  • (12) United States Patent (10) Patent No.: US 8,455,647 B2 Delong Et Al
    USOO8455647B2 (12) United States Patent (10) Patent No.: US 8,455,647 B2 deLong et al. (45) Date of Patent: *Jun. 4, 2013 (54) 6-AMINOISOQUINOLINE COMPOUNDS 7,671,205 B2 3/2010 deLong et al. 8,034,943 B2 10/2011 delong et al. 2004/0091946 A1 5/2004 Oakley et al. (75) Inventors: Mitchell A. deLong, Chapel Hill, NC 2005/OO32125 A1 2/2005 Oakley et al. (US); Jill Marie Sturdivant, Chapel 2005/0176712 A1 8/2005 Wakabayashi et al. Hill, NC (US); Geoffrey Richard 2005/0282805 A1 12/2005 Hangeland et al. Heintzelman, Durham, NC (US); Susan 2006/027O670 A1 11/2006 Chew et al. M. Royalty, Cary, NC (US) 2007/011 1983 A1 5/2007 Fong 2007/O123561 A1 5/2007 Lee et al. 2007/01294.04 A1 6/2007 Hagihara et al. (73) Assignee: Aerie Pharmaceuticals, Inc., Research 2007/O135499 A1 6/2007 deLong et al. Triangle Park, NC (US) 2007/0142429 A1 6/2007 deLong et al. 2007/O149473 A1 6/2007 Chatterton et al. (*) Notice: Subject to any disclaimer, the term of this 2007/014.9548 A1 6/2007 Hellberg et al. patent is extended or adjusted under 35 2007/0167444 A1 7/2007 Kuramochi et al. 2007/0173530 A1 7/2007 deLong et al. U.S.C. 154(b) by 0 days. 2007/0238741 A1 10/2007 Nagarathnam et al. 2008, 0021026 A1 1/2008 Kahraman et al. This patent is Subject to a terminal dis 2008, 0021217 A1 1/2008 Borchardt et al. claimer. 2008, OO58384 A1 3/2008 Lee et al.
    [Show full text]
  • Chlorobenzene
    CHLOROBENZENE What is CHLOROBENZENE? Chlorobenzene is a man-made colorless liquid that burns quickly. It has a pleasant smell like the smell of almonds. Some of it will dissolve in water. It also turns into a vapor and goes into the air. Chlorobenzene is not found in nature. Where can chlorobenzene be found and how is it used? Over the past 40 years in the United States, less cholorobenzene is being manufactured. In the past, cholorobenzene was used to make phenol and DDT. Today, it is still used to produce pesticides and chemicals used to prevent or kill unwanted pests. Chlorobenzene may be also be used to grease car parts. Chlorobenzene sent into the air is slowly broken down by other chemicals and sunlight. It can be removed from the air by rain. In water, chlorobenzene will quickly turn into a vapor, or be broken down by bacteria. When it enters soil, most of it is broken down quickly by bacteria and the rest will turn into a vapor or leach into groundwater. How can people be exposed to chlorobenzene? You could be exposed to chlorobenzene through: Breathing the chemical. People who work in places where chlorobenzene is processed or handled are at greatest risk. If you live near a waste site, you could be exposed to vapors in the air. Eating or drinking food or water that has been in contact with chlorobenzene. If you live near a waste site, you could be exposed from water contaminated by chlorobenzene. Touching soil contaminated with chlorobenzene. This happens to people who live near a waste site or a factory.
    [Show full text]
  • Reactions of Aromatic Compounds Just Like an Alkene, Benzene Has Clouds of  Electrons Above and Below Its Sigma Bond Framework
    Reactions of Aromatic Compounds Just like an alkene, benzene has clouds of electrons above and below its sigma bond framework. Although the electrons are in a stable aromatic system, they are still available for reaction with strong electrophiles. This generates a carbocation which is resonance stabilized (but not aromatic). This cation is called a sigma complex because the electrophile is joined to the benzene ring through a new sigma bond. The sigma complex (also called an arenium ion) is not aromatic since it contains an sp3 carbon (which disrupts the required loop of p orbitals). Ch17 Reactions of Aromatic Compounds (landscape).docx Page1 The loss of aromaticity required to form the sigma complex explains the highly endothermic nature of the first step. (That is why we require strong electrophiles for reaction). The sigma complex wishes to regain its aromaticity, and it may do so by either a reversal of the first step (i.e. regenerate the starting material) or by loss of the proton on the sp3 carbon (leading to a substitution product). When a reaction proceeds this way, it is electrophilic aromatic substitution. There are a wide variety of electrophiles that can be introduced into a benzene ring in this way, and so electrophilic aromatic substitution is a very important method for the synthesis of substituted aromatic compounds. Ch17 Reactions of Aromatic Compounds (landscape).docx Page2 Bromination of Benzene Bromination follows the same general mechanism for the electrophilic aromatic substitution (EAS). Bromine itself is not electrophilic enough to react with benzene. But the addition of a strong Lewis acid (electron pair acceptor), such as FeBr3, catalyses the reaction, and leads to the substitution product.
    [Show full text]
  • Ligand-Based Pharmacophore Studies in the Dopaminergic System Amar P
    University of Wollongong Research Online University of Wollongong Thesis Collection University of Wollongong Thesis Collections 2011 Ligand-based pharmacophore studies in the dopaminergic system Amar P. Inamdar University of Wollongong Recommended Citation Inamdar, Amar P., Ligand-based pharmacophore studies in the dopaminergic system, Doctor of Philosophy thesis, School of Chemistry, University of Wollongong, 2011. http://ro.uow.edu.au/theses/3535 Research Online is the open access institutional repository for the University of Wollongong. For further information contact Manager Repository Services: [email protected]. LIGAND-BASED PHARMACOPHORE STUDIES IN THE DOPAMINERGIC SYSTEM A thesis submitted in partial fulfilment of the requirements for the award of the degree DOCTOR OF PHILOSOPHY From UNIVERSITY OF WOLLONGONG By AMAR P. INAMDAR, B.PHARM., M.PHARM. SCHOOL OF CHEMISTRY November 2011 THESIS CERTIFICATION I, Amar P. Inamdar, declare that this thesis, submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy, in the School of Chemistry, University of Wollongong, is wholly my own work unless otherwise referenced or acknowledged. The document has not been submitted for qualifications at any other academic institution. Amar P. Inamdar November 2011 i ACKNOWLEDGEMENTS I am truly grateful to my supervisor, Prof. John B. Bremner, whose support, encouragement and guidance has helped me immensely in the completion of this project. Most importantly, I am thankful for his patience over all these years and believing in me in spite of various difficult periods in this journey. I know he has sacrificed a significant amount of his personal time to make this happen. I also owe my deepest gratitude to Associate Prof.
    [Show full text]
  • Toxicological Profile for Chlorobenzene
    TOXICOLOGICAL PROFILE FOR CHLOROBENZENE Agency for Toxic Substances and Disease Registry U.S. Public Health Service December 1990 ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. 1 1. PUBLIC HEALTH STATEMENT This Statement was prepared to give you information about chlorobenzene and to emphasize the human health effects that may result from exposure to it. The Environmental Protection Agency (EPA) has identified 1,177 sites on its National Priorities List (NPL). Chlorobenzene has been found at 97 of these sites. However, we do not know how many of the 1,177 NPL sites have been evaluated for chlorobenzene. As EPA evaluates more sites, the number of sites at which chlorobenzene is found may change. The information is important for you because chlorobenzene may cause harmful health effects and because these sites are potential or actual sources of human exposure to chlorobenzene. When a chemical is released from a large area, such as an industrial plant, or from a container, such as a drum or bottle, it enters the environment as a chemical emission. This emission, which is also called a release, does not always lead to exposure. You can be exposed to a chemical only when you come into contact with the chemical. You may be exposed to it in the environment by breathing, eating, or drinking substances containing the chemical or from skin contact with it. If you are exposed to a hazardous substance such as chlorobenzene, several factors will determine whether harmful health effects will occur and what the type and severity of those health effects will be.
    [Show full text]
  • Kinetic Investigation of Nitroarylation of Pyrrole with 1-Chloro-4
    ienc Sc es al J c o i u m r e n a h l C Selvaraj et al., Chem Sci J 2015, 6:3 Chemical Sciences Journal DOI: 10.4172/2150-3494.1000104 ISSN: 2150-3494 Research Article Article OpenOpen Access Access Kinetic Investigation of Nitroarylation of Pyrrole with 1-Chloro-4- Nitrobenzene Using a New Multi-Site Phase-Transfer Catalyst under Ultrasonic Condition Selvaraj V1*, Harikumar K2, Sathiyaraj M3 and Rajendran V3 1PG Department of Chemistry, Sri Akilandeswari Women’s College, Wandiwash, Tamil Nadu, India 2Sri Chandrashekarendra Saraswathi Viswa Maha Vidyalaya University, Kanchipuram, Enathur, Tamil Nadu, India 3Department of Chemistry, Pachaiyappa’s College for Men, Kanchipuram, Tamil Nadu, India Abstract In the present research work, the solid-liquid reaction was successfully carried out in the new synthesized multi- site phase-transfer catalyst, namely i.e., 1,3,5-tribenzyl-1,3,5-triethyl-1,3,5-triazinane-1,3,5-triium trichloride(MPTC), and sonication (40 kHz, 300 W) to produce the desired product namely 1-(4-nitropheny) pyrrole from pyrrole and 4-nitrochlorobenzene. The selectivity of N-arylation product was obtained under sonication and MPTC. The combination of ultrasound and MPTC resulted in better efficacy as compared to the individual operations. The apparent reaction rate is greatly enhanced and observed to obey the pseudo-first order kinetics. The appk value increases with increasing kinetic parameters that is the amount of [MPTC], [substrate], ultrasonication, stirring speed, temperature, etc. Keywords: Sonochemistry; Pyrrole; Interfacial reaction; Kinetics; The effect of ultrasonic energies in organic syntheses (homogeneous MPTC; 1-Chloro-4-Nitrobenzene and heterogeneous reactions) has been boosted in recent years [21-27].
    [Show full text]
  • Chlorobenzenes (PDF)
    EPA-454/R-93-044 LOCATING AND ESTIMATING AIR EMISSIONS FROM SOURCES OF CHLOROBENZENES (REVISED) Office of Air Quality Planning and Standards U.S. Environmental Protection Agency Research Triangle Park, North Carolina 27711 March 1994 This report has been reviewed by the Office of Air Quality Planning and Standards, U.S. Environmental Protection Agency, and has been approved for publication. Any mention of trade names or commercial products is not intended to constitute endorsement or recommendation for use. ii CONTENTS Section Page DISCLAIMER ..................................................... ii LIST OF FIGURES .................................................. vi LIST OF TABLES .................................................. vii 1.0 PURPOSE OF DOCUMENT ..................................... 1-1 1.1 Reference for Section 1.0 ................................... 1-5 2.0 OVERVIEW OF DOCUMENT CONTENTS .......................... 2-1 2.1 References for Section 2.0 .................................. 2-5 3.0 BACKGROUND .............................................. 3-1 3.1 Nature of Pollutant ....................................... 3-1 3.1.1 Properties of Chlorobenzenes ........................... 3-5 3.1.2 Properties of Monochlorobenzene ........................ 3-6 3.1.3 Properties of Dichlorobenzenes .......................... 3-6 3.1.4 Properties of Trichlorobenzenes ......................... 3-7 3.1.5 Properties of Hexachlorobenzene ........................ 3-7 3.2 Overview of Production and Use .............................. 3-8 3.3
    [Show full text]
  • Agency for Toxic Substances and Disease Registry U.S. Public Health Service
    TOXICOLOGICAL PROFILE FOR CHLOROBENZENE Agency for Toxic Substances and Disease Registry U.S. Public Health Service December 1990 ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. iii FOREWORD The Superfund Amendments and Reauthorization Act (SARA) of 1986 (Public Law 99-499) extended and amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund). This public law directed the Agency for Toxic Substances and Disease Registry (ATSDR) to prepare toxicological profiles for hazardous substances which are most commonly found at facilities on the CERCLA National Priorities List and which pose the most significant potential threat to human health, as determined by ATSDR and the Environmental Protection Agency (EPA). The lists of the 250 most significant hazardous substances were published in the Federal Register on April 17, 1987, on October 20, 1988, on October 26, 1989, and on October 17, 1990. Section 104(i)(3) of CERCLA, as amended, directs the Administrator of ATSDR to prepare a toxicological profile for each substance on the list. Each profile must include the following content: (A) An examination, summary, and interpretation of available toxicological information and epidemiological evaluations on the hazardous substance in order to ascertain the levels of significant human exposure for the substance and the associated acute, subacute, and chronic health effects, (B) A determination of whether adequate information on the health effects of each substance is available or in the process of development to determine levels of exposure which present a significant risk to human health of acute, subacute, and chronic health effects, and (C) Where appropriate, an identification of toxicological testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans.
    [Show full text]
  • Safety Data Sheet Acc
    Page 1/10 Safety Data Sheet acc. to OSHA HCS Printing date 03/31/2019 Version Number 2 Reviewed on 03/31/2019 * 1 Identification · Product identifier · Trade name: Chlorobenzene-d5 Standard (1X1 mL) · Part number: STS-300-1 · Application of the substance / the mixture Reagents and Standards for Analytical Chemical Laboratory Use · Details of the supplier of the safety data sheet · Manufacturer/Supplier: Agilent Technologies, Inc. 5301 Stevens Creek Blvd. Santa Clara, CA 95051 USA · Information department: Telephone: 800-227-9770 e-mail: [email protected] · Emergency telephone number: CHEMTREC®: 1-800-424-9300 2 Hazard(s) identification · Classification of the substance or mixture GHS02 Flame Flam. Liq. 2 H225 Highly flammable liquid and vapor. GHS06 Skull and crossbones Acute Tox. 3 H331 Toxic if inhaled. GHS08 Health hazard STOT SE 1 H370 Causes damage to organs. · Label elements · GHS label elements The product is classified and labeled according to the Globally Harmonized System (GHS). · Hazard pictograms GHS02 GHS06 GHS08 · Signal word Danger · Hazard-determining components of labeling: methanol · Hazard statements Highly flammable liquid and vapor. Toxic if inhaled. Causes damage to organs. (Contd. on page 2) US 48.1.26 Page 2/10 Safety Data Sheet acc. to OSHA HCS Printing date 03/31/2019 Version Number 2 Reviewed on 03/31/2019 Trade name: Chlorobenzene-d5 Standard (1X1 mL) (Contd. of page 1) · Precautionary statements Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/equipment. Use only non-sparking tools. Take precautionary measures against static discharge.
    [Show full text]
  • Report on Carcinogens, Fourteenth Edition for Table of Contents, See Home Page
    Report on Carcinogens, Fourteenth Edition For Table of Contents, see home page: http://ntp.niehs.nih.gov/go/roc 1,4-Dichlorobenzene Property Information Molecular weight 147.0 CAS No. 106-46-7 Density 1.2475 g/mL at 20°C/4°C Melting point 52.7°C Reasonably anticipated to be a human carcinogen Boiling point 174°C at 760 mm Hg Log K 3.44 First listed in the Fifth Annual Report on Carcinogens (1989) ow Water solubility 0.076 g/L at 25°C Also known as p-dichlorobenzene Vapor pressure 1.7 mm Hg at 25°C Vapor density relative to air 5.08 Source: HSDB 2009. Cl Cl Use Carcinogenicity 1,4-Dichlorobenzene has been used primarily as a space deodorant in 1,4-Dichlorobenzene is reasonably anticipated to be a human car- products such as room deodorizers and toilet deodorant blocks and cinogen based on sufficient evidence of carcinogenicity from studies as a fumigant for moth control (accounting for about 35% to 55% of in experimental animals. the 1,4-dichloro benzene produced) (ATSDR 1998). In 2007, it was used primarily as an intermediate in the production of polyphenyl- Cancer Studies in Experimental Animals ene sulfide, a plastic used in the electrical and electronics industries Oral exposure to 1,4-dichlorobenzene caused tumors at several dif- (52%), in the production of 1,2,4-trichlorobenzene room deodorant ferent tissue sites in mice and rats. Administration of 1,4-dichloro- (22%), and for moth control (15%) (CMR 2004). Other uses of 1,4-di- benzene by stomach tube caused benign and malignant liver tumors chlorobenzene include use as a germicide or disinfectant; a soil fumi- (hepatocellular adenoma and carcinoma) in mice of both sexes and gant; an insecticide for fruit borers and ants; a chemical intermediate kidney cancer (tubular-cell adenocarcinoma) and mononuclear-cell in the production of various dyes, pharmaceuticals, and resin-bonded leukemia in male rats.
    [Show full text]
  • Provisional Peer-Reviewed Toxicity Values for Diphenyl Ether (Casrn 101-84-8)
    EPA/690/R-17/009 FINAL 09-26-2017 Provisional Peer-Reviewed Toxicity Values for Diphenyl Ether (CASRN 101-84-8) Superfund Health Risk Technical Support Center National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Cincinnati, OH 45268 AUTHORS, CONTRIBUTORS, AND REVIEWERS CHEMICAL MANAGER Jon B. Reid, PhD, DABT National Center for Environmental Assessment, Cincinnati, OH DRAFT DOCUMENT PREPARED BY SRC, Inc. 7502 Round Pond Road North Syracuse, NY 13212 PRIMARY INTERNAL REVIEWERS Elizabeth Owens, PhD National Center for Environmental Assessment, Cincinnati, OH Anuradha Mudipalli, MSc, PhD National Center for Environmental Assessment, Research Triangle Park, NC This document was externally peer reviewed under contract to: Eastern Research Group, Inc. 110 Hartwell Avenue Lexington, MA 02421-3136 Questions regarding the content of this PPRTV assessment should be directed to the EPA Office of Research and Development’s National Center for Environmental Assessment, Superfund Health Risk Technical Support Center (513-569-7300). ii Diphenyl Ether TABLE OF CONTENTS COMMONLY USED ABBREVIATIONS AND ACRONYMS .................................................. iv BACKGROUND .............................................................................................................................1 DISCLAIMERS ...............................................................................................................................1 QUESTIONS REGARDING PPRTVs ............................................................................................1
    [Show full text]
  • Synthesis of Novel Azetidines
    University of New Orleans ScholarWorks@UNO University of New Orleans Theses and Dissertations Dissertations and Theses Fall 12-20-2013 Synthesis of Novel Azetidines Amber Thaxton UNO, [email protected] Follow this and additional works at: https://scholarworks.uno.edu/td Part of the Medicinal and Pharmaceutical Chemistry Commons, and the Organic Chemistry Commons Recommended Citation Thaxton, Amber, "Synthesis of Novel Azetidines" (2013). University of New Orleans Theses and Dissertations. 1764. https://scholarworks.uno.edu/td/1764 This Dissertation is protected by copyright and/or related rights. It has been brought to you by ScholarWorks@UNO with permission from the rights-holder(s). You are free to use this Dissertation in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s) directly, unless additional rights are indicated by a Creative Commons license in the record and/ or on the work itself. This Dissertation has been accepted for inclusion in University of New Orleans Theses and Dissertations by an authorized administrator of ScholarWorks@UNO. For more information, please contact [email protected]. Synthesis of Novel Azetidines A Dissertation Submitted to the Graduate Faculty of the University of New Orleans in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry by Amber Nichole Thaxton B.S. Clemson University, 2004 M.S. University of New Orleans, 2013 December 2013 For my family: To my mom, Bee Thaxton, for everything she has done for me. I am extremely thankful for her constant support and reassurance.
    [Show full text]