WHC (2007) 068 Parc Cathays Caerdydd CF10 3NQ Cathays Park Cardiff CF10 3NQ Issue Date: October 2007 Status: Information Title

WHC (2007) 068

WELSH HEALTH CIRCULAR

Parc Cathays Cathays Park Caerdydd CF10 3NQ Cardiff CF10 3NQ

Issue Date: October 2007 Status: Information

Title: National Institute for Health and Clinical Excellence (NICE) : 16th wave work programme

For Action by: Chief Executives of Local Action required : See Paragraph 2 Health Boards; Chief Executives of NHS Trusts

For Information to: Distribution list attached

Sender: Wendy Chatham, Director, Quality, Standards and Safety Improvement Directorate, Department for Health and Social Services, Welsh Assembly Government, Cathays Park, Cardiff, CF10 3NQ, 02920 825528

Welsh Assembly Government contacts : Dominic Worsey, Healthcare Standards, Quality, Standards and Safety Improvement Directorate, Health and Social Care Department, Welsh Assembly Government, Cathays Park, Cardiff, CF10 3NQ, Tel: 029 2082 3083 dominic.worsey@wales.gsi.gov.uk

Distribution List

Chief Executives Local Health Boards Medical Directors Local Health Boards Chief Executives NHS Trusts Medical Directors NHS Trusts Chief Executive NHS Confederation Director Welsh NHS Confederation Director Board of Community Health Councils in Wales Director Welsh Local Government Association Chief Executive Commission for Racial Equality Secretary British Dental Association in Wales Postgraduate Dean University of Wales College of Medicine Director information services University of Wales College of Medicine Secretary British Medical Association (Wales) Regional Head of Health UNISON Board Secretary Royal College of Nursing (Wales) Welsh Council Representative British Dietetic Association Wales Secretary British Orthoptic Society Regional Secretary The GMB Chair Community Pharmacy Wales Chair Royal College of General Practitioners General Secretary Wales TUC Assistant Director Chartered Society of Physiotherapists Officer for Wales Society of Radiographers IR Officer Society of Chiropodists and Podiatrists Regional Secretary Union of Construction Allied Trades and Technicians Board Secretary for Wales Royal College of Midwives Welsh Executive Royal Pharmaceutical Society of Great Britain Information Officer Wales Council for Voluntary Action Business manager Institute of Health Care Management Welsh Division Chief Executive Association of Optometrists Librarian British College of Optometrists Secretariat Statutory Committees Regional Directors NHS Wales Regional Offices Chief Executive Health Commission Wales (Specialist Services) Librarian National Public Health Service Chief Executive Welsh Language Board / Bwrdd yr Iaith Gymraeg Chief Executive Healthcare Inspectorate Wales Children’s Commissioner Children’s Commissioner for Wales Chief Executive Children in Wales Head of International Regulation Council for Healthcare Regulatory Excellence Commissioner for Wales Disability Rights Commission Wales Chief Executive Disability Wales Head of Welsh Affairs General Medical Council Wales Chief Executive Healthcare Commission Chief Executive Health and Personal Social Services Regulation and Improvement Authority Chairperson Interim Health Information & Quality Authority

Chief Executive Mental Health Act Commission Chief Executive National Leadership & Innovation Agency for Healthcare Chief Executive National Institute for Health & Clinical Excellence Chief Executive National Patient Safety Agency Director Welsh Health Estates Chief Executive Postgraduate Medical Education and Training Board Manager Welsh Risk Pool Regional Director Health & Safety Executive Ombudsman Public Services Ombudsman for Wales Director NHS Centre for Equality & Human Rights Chief Executive NHS Quality Improvement Scotland Auditor General for Wales Wales Audit Office Chief Executive Wales Centre for Health Chief Executive Care Standards Inspectorate for Wales Chief Inspector Social Services Inspectorate for Wales Chair Academy of Royal Colleges in Wales Chief Executive Royal College of Speech & Language Therapists Director of Wales Association of the British Pharmaceutical Industry Wales Chief Executive British Psychological Society Regional Manager MENCAP Cymru Policy Officer Wales College of Occupational Therapists Director MIND (National Association for Mental Health) Cymru Secretary to the Welsh Board Royal College of Midwives Secretariat Welsh Independent Hospitals Association Specialist Pharmacist, Quality Welsh Pharmaceutical Quality Assurance Assurance and Control Wales Patch Managers Business Service Centres across Wales

National Institute for Health and Clinical Excellence (NICE): 16th wave work programmes

Dear Colleague

Purpose 1. To draw your attention to the 16th wave work programmes, which have recently been referred to NICE.

Action 2. Chief Executives are asked to note the topics which are being referred and ensure that systems are in place to prepare for the guidance as and when issued by NICE.

Background 3. NICE appraises the clinical benefits and costs of health care interventions notified to it by Ministers at the Department of Health, following consultation with the Welsh Assembly Government. Topics are referred to NICE in batches known colloquially as a “wave”. Each “wave” could potentially be split into three areas under which the Institute will produce guidance:

• Technology appraisals - guidance on the use of new and existing medicines and treatments within the NHS in England and Wales. This guidance is subject to the three month funding Direction issued by the Minister for Health and Social Services on 23 October 2003.

• Clinical guidelines - guidance on the appropriate treatment and care of people with specific diseases and conditions within the NHS in England and Wales.

• Public Health Topics - the promotion of good health and the prevention of ill health for those working in the NHS, local authorities, and the wider public and Voluntary Sector. Please note: NICE public health guidance does not apply to Wales

16th wave work programme

4. The programme comprises:

• Six technology appraisals • Four clinical guidelines and one short clinical guideline • One public health topic

5. Details of the topics are given at Annex A

6. NICE will factor these new topics into its existing work programme and begin work on the guidance as soon as logistically possible. There will be several opportunities to comment on drafts of each individual piece of guidance produced by NICE, before the final guidance is issued. Information on the timescales involved in each of the topics will appear on NICE’s website: www.nice.org.uk

7. For further information please contact Dominic Worsey, Healthcare Standards Branch, Quality, Standards and Safety Improvement Directorate, Health and Social Care Department, Welsh Assembly Government, Cathays Park, Cardiff CF10 3NQ. Tel: 029 2082 3083. E-mail: [email protected]

Yours sincerely

Wendy Chatham Director of Quality, Standards and Safety Improvement Directorate Health and Social Care Department

Annex A 16th Wave Technology Appraisals

Single Technology Appraisals (STA)

Cetuximab for metastatic colorectal cancer To appraise the clinical and cost effectiveness of cetuximab for second and third line treatment of metastatic colorectal cancer following the failure of oxaliplatin-inducing chemotherapy

Cetuximab for metastatic and/or recurrent squamous cell carcinoma of the head and neck To appraise the clinical and cost effectiveness of cetuximab in combination with platinum- based chemotherapy for metastatic and/or recurrent squamous cell carcinoma of the head and neck.

Multiple Technology Appraisals (MTA)

IMRT (Intensity-Modulated Radiation Therapy) in specific cancers To appraise the clinical and cost effectiveness of IMRT (Intensity-Modulated Radiation Therapy) in specific cancers.

Topical negative pressure for wound management To appraise the clinical and cost effectiveness of topical negative pressure for wound management.

Multi-detector CT angiography for coronary artery disease To appraise the clinical and cost effectiveness of multi-detector computed tomography (CT) angiography for the diagnosis and management of coronary artery disease.

Scoping to determine if STA or MTA

Aliskiren for hypertension To appraise the clinical and cost effectiveness of aliskiren for the treatment of hypertension.

16th Wave Clinical Guidelines

Clinical Guidelines

Multiple pregnancy To prepare a clinical guideline on the management of multiple pregnancy.

Transient loss of consciousness (T-LOC) in adults To prepare a clinical guideline on the management of transient loss of consciousness (T- LOC) in adults.

Men with lower urinary tract symptoms To prepare a guideline on the assessment, investigation, management and onward referral of men with lower urinary tract symptoms (including male incontinence) within primary care.

Primary colorectal and anal cancer To prepare a clinical guideline on the diagnosis and management of patients with all stages of primary colorectal and anal cancer. This excludes any population screening and surveillance of high-risk groups, including patients with a family history and patients with inflammatory bowel disease.

Short Clinical Guideline

Critical illness - rehabilitation The rehabilitation of adults after a period of critical illness requiring a stay on ITU of over 5 days

16th Wave Public Health Guidance

Mental wellbeing of young people in secondary education To produce public health intervention guidance for the promotion of the mental wellbeing of young people in secondary education using whole school approaches and targeted activities.