www.aging-us.com AGING 2021, Vol. 13, No. 8 Research Paper Overexpression of long non-coding RNA AP001505.9 inhibits human hyaline chondrocyte dedifferentiation Lin Chen1,2, Jinying Xu1, Shuang Lv1, Yan Zhao1,3, Dongjie Sun1, Yangyang Zheng1, Xianglan Li1,4, Lihong Zhang1, Guangfan Chi1, Yulin Li1 1The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China 2Department of Gastrointestinal and Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China 3Department of Operating Room, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China 4Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China Correspondence to: Yulin Li, Guangfan Chi; email:
[email protected],
[email protected] Keywords: long non-coding RNA AP001505.9, dedifferentiation, hyaline chondrocyte, autologous chondrocyte implantation, osteoarthritis Received: December 8, 2020 Accepted: February 18, 2021 Published: April 4, 2021 Copyright: © 2021 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Autologous chondrocyte implantation (ACI) is an effective method for treating chronic articular cartilage injury and degeneration; however, it requires large numbers of hyaline chondrocytes, and human hyaline chondrocytes often undergo dedifferentiation in vitro. Moreover, although long non-coding RNAs (lncRNAs) regulate gene expression in many pathological and physiological processes, their role in human hyaline chondrocyte dedifferentiation remains unclear. Here, we examined lncRNA and mRNA expression profiles in human hyaline chondrocyte dedifferentiation using microarray analysis.