DOCSLIB.ORG

(12) Patent Application Publication (10) Pub. No.: US 2016/0081959 A1 Bartos Et Al

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(12) Patent Application Publication (10) Pub. No.: US 2016/0081959 A1 Bartos Et Al US 20160O81959A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2016/0081959 A1 BartOS et al. (43) Pub. Date: Mar. 24, 2016 (54) METHOD OF USING ARGINNE SILICATE Publication Classification NOSITOL COMPLEX FOR WOUND HEALING OR REPAIR (51) Int. Cl. A63L/98 (2006.01) (71) Applicant: Glanbia plc, Carlsbad, CA (US) A63L/047 (2006.01) A6II 45/06 (2006.01) (72) Inventors: Jeremy David Bartos, San Marcos, CA A619/00 (2006.01) (US); Mayuresh Dilip Bedekar, (52) U.S. Cl. Carlsbad, CA (US) CPC ............. A6 IK3I/198 (2013.01); A61 K9/0053 (2013.01); A61 K9/0014 (2013.01); A61 K (73) Assignee: GLANBLA PLC, Carlsbad, CA (US) 9/0019 (2013.01); A61K3I/047 (2013.01); A61K 45/06 (2013.01) (21) Appl. No.: 14/850,685 (57) ABSTRACT A method for treating a wound or injury in an individual is (22) Filed: Sep. 10, 2015 provided, comprising the steps of administering to the indi vidual afflicted with the wound or injury a composition Related U.S. Application Data including an effective amount of arginine silicate inositol (60) Provisional application No. 62/054,789, filed on Sep. (ASI), optionally in combination with another component, 24, 2014. and a nutraceutically or pharmaceutically acceptable carrier. Patent Application Publication Mar. 24, 2016 Sheet 2 of 2 US 2016/0081959 A1 Mean Plasma Arginine Levels (Human Study) 409/o 359/6 309/o 259/o 200/o 150/6 109/ 59/o Time (hrs) FIG. 2 US 2016/008 1959 A1 Mar. 24, 2016 METHOD OF USING ARGINNE SILICATE SUMMARY NOSITOL COMPLEX FOR WOUND 0009. A nutritional composition is provided comprising HEALING OR REPAIR an effective amount of arginine silicate inositol (ASI), option 0001. This application claims the benefit of earlier filed ally in combination with another component, and a nutraceu U.S. Provisional application No. 62/054,789, filedon Sep. 24, tically acceptable carrier. 2014, which is hereby incorporated by reference herein. 0010. Other optional components can include compounds selected from vasodilators, NO-precursors, or eNOS activa TECHNICAL FIELD tors. Further optional components can include compounds selected from proline, hydroxyproline, IGF-1 activators, or 0002. A method of using arginine silicate inositol (ASI) polyamine precursors. complex is provided, optionally in combination with one or 0011. A method for treating a wound in an individual is more nutritional components, flavoring compounds, dietary provided, comprising the steps of administering to the indi Supplements, or other edible components. In an embodiment, vidual in need of Such treatment a composition including an a nutritional composition includes ASI. In another embodi effective amount of arginine silicate inositol (ASI), optionally ment, ASI is used in a method of treating wounds, i.e. wound in combination with another component, and a nutraceuti healing or repair. cally or pharmaceutically acceptable carrier. The present method can include oral/nutritional, intravenous, or topical BACKGROUND treatment. 0003 Treatment of wounds and other acute injuries is one of the primary responsibilities taken on by first responders BRIEF DESCRIPTION OF THE DRAWINGS (e.g., police, firemen, military, EMTs, and all manner of 0012 FIG. 1 depicts plasma concentration of arginine (ug/ emergency medical service (EMS) personnel) and medical ml) over time as single dose oral pharmacokinetic results staff (e.g., nurses, orderlies, military medics, triage or emer from testing in fasted male Sprague Dawley rates (equivalent gency room staff, physicians, and Surgeons). Methods of dose of 500 mg/kg. L-Arginine) for L-Arginine (free base), treatment for wounds are a critical need often requiring L-Arginine HCl, ResArgin, and Arginine silicate inositol immediate care. Many established methods of treatment are (ASI). known, included Standard first aid (field dressing and bandag 0013 FIG. 2 depicts percent change in concentration of ing), administration of drugs or medicines, and Surgical repair plasma L-arginine in human Subjects after a single dose of including Stitching, grafting and bone-setting. ASI, represented as mean value vs. time, relative to baseline. 0004 Apart from a human emergency scenario, wound treatment and/or wound healing are an important component DETAILED DESCRIPTION of medical treatment for recovery after injury. Additionally, 0014 Wounds are injuries that break the skin or other body certain chronic or degenerative conditions may require con tissues. They include cuts, scrapes, scratches, burns, electri stant vigilance with respect to treatment of wounds or lesions. cal wounds, bites, stings, incisions, amputations, and punc Indeed, a key component of wound healing and/or repair tured skin. They often happen because of an accident, but involves regenerative processes including reestablishing Surgery, Sutures, and Stitches also cause wounds. homeostasis in the affected tissues (Wong, et al., “Wound 0015. As used herein, “wound healing refers to a biologi Healing: A Paradigm for Regeneration.” Mayo Clin. Proc. cally-mediated process of repair or remodeling that may (2013) 88(9): 1022-1031). involve treatment of skin or other body tissues with a medici 0005. Currently, researchers are taking a more holistic nal or nutritional composition. Such treatments as applied to view of human health and nutrition. Thus, integration of good the human body may include, but are not limited to, treatment nutrition into the daily routine is one way of maintaining good of damage or insult to skin, tissue, and organs, wherein the immune balance, cardiac and muscular tone, and metabolic affected area may be, for example, cutaneous, Subcutaneous, efficiency. For example, a human clinical study on the effects visceral, circulatory, lymphatic, gastrointestinal, mucosal, of 17 g/day of arginine on wound healing was performed on skeletal, muscular, etc. 30 elderly patients who sustained an experimental Surgical 0016. In one example, human skin is a remarkably plastic injury. After two weeks Supplemented patients demonstrated organ that Sustains insult and injury throughout life. Its ability significantly greater hydroxyproline and protein accumula to expeditiously repair wounds is paramount to Survival and is tion at the wound site when compared to non-supplemented thought to be regulated by wound components such as differ controls. Lymphocyte response was also elevated in the entiated cells, stem cells, cytokine networks, extracellular Supplemented group, as was IGF-1 (Kirk, et al., Surgery matrix, and mechanical forces. These intrinsic regenerative (1993) 114(2): 155-160). pathways are integrated across different skin compartments 0006. In another example of the potential for wound heal and are being elucidated on the cellular and molecular levels. ing, arginine has been used to treat anal fissures (Gosselinket Recent advances in bioengineering and nanotechnology have al., Dis. Colon Rectum (2005) 48(4):832-7). allowed researchers to manipulate these microenvironments 0007. However, arginine suffers from drawbacks includ in increasingly precise spatial and temporal scales, recapitu ing low bioavailability and an undesirable taste. Better treat lating key homeostatic cues that may drive regeneration. ments and/or products are needed for therapeutic and/or 0017. As used herein, “arginine' is intended to mean nutritional use that can replace arginine alone. One useful L-arginine (Arg), a naturally occurring amino acid, with or material is arginine silicate inositol (ASI) complex. without a salt counterion, available in purified form from 0008. Therefore, if certain nutritional products containing Glanbia Nutritionals, Inc. (Carlsbad, Calif.). ASI were able to promote wound healing, this would repre 0018. It has now unexpectedly been found that arginine sent a contribution to the medical and nutritional arts. silicate inositol (ASI) complex may be used to make an edible US 2016/008 1959 A1 Mar. 24, 2016 nutritional composition that is effective for treating wounds, increased bioavailability of the arginine coming from the ASI. i.e., useful for wound healing or repair. It is believed that In addition, arginine is known to have a very unpleasant taste ASI-containing compositions are useful for treating wounds which makes it relatively unpalatable, especially for patients including, but not limited to, cuts, scrapes, scratches, burns, coming off of Surgery who may be suffering from nausea or electrical wounds, bites, stings, incisions, amputations, anal who have other wound healing needs. The smaller dose of fissures, punctured skin, and the like. ASI compared to other forms of arginine may help make a 0019. In addition, the arginine and silica from ASI are product more palatable or may be easier to mask flavor-wise. highly bioavailable meaning that less is needed to provide a 0025 Silicate is also a component of ASI and may also similar effect seen from other arginine sources. Stated in contribute to wound healing on its own. As used herein, another way, ASI contains about 40% by weight arginine. The 'silicate” means any of a number of materials including, but combination of the components as conjugates (silicon at 8% not limited to silica, Silica-containing compounds, silicate and inositol at 25%) make it more easily absorbed. Adminis salts, esters, and the like. Useful cationic counterions for tration of less arginine is needed to provide overall improve silicate include, but are not limited to, sodium, potassium, ment in taste, independent of the use of sweeteners or other lithium, calcium, magnesium, and the like. Silica
Load more

Recommended publications
  • )&F1y3x PHARMACEUTICAL APPENDIX to THE
    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ACTODIGIN 36983-69-4 ABANOQUIL 90402-40-7 ADAFENOXATE 82168-26-1 ABCIXIMAB 143653-53-6 ADAMEXINE 54785-02-3 ABECARNIL 111841-85-1 ADAPALENE 106685-40-9 ABITESARTAN 137882-98-5 ADAPROLOL 101479-70-3 ABLUKAST 96566-25-5 ADATANSERIN 127266-56-2 ABUNIDAZOLE 91017-58-2 ADEFOVIR 106941-25-7 ACADESINE 2627-69-2 ADELMIDROL 1675-66-7 ACAMPROSATE 77337-76-9 ADEMETIONINE 17176-17-9 ACAPRAZINE 55485-20-6 ADENOSINE PHOSPHATE 61-19-8 ACARBOSE 56180-94-0 ADIBENDAN 100510-33-6 ACEBROCHOL 514-50-1 ADICILLIN 525-94-0 ACEBURIC ACID 26976-72-7 ADIMOLOL 78459-19-5 ACEBUTOLOL 37517-30-9 ADINAZOLAM 37115-32-5 ACECAINIDE 32795-44-1 ADIPHENINE 64-95-9 ACECARBROMAL 77-66-7 ADIPIODONE 606-17-7 ACECLIDINE 827-61-2 ADITEREN 56066-19-4 ACECLOFENAC 89796-99-6 ADITOPRIM 56066-63-8 ACEDAPSONE 77-46-3 ADOSOPINE 88124-26-9 ACEDIASULFONE SODIUM 127-60-6 ADOZELESIN 110314-48-2 ACEDOBEN 556-08-1 ADRAFINIL 63547-13-7 ACEFLURANOL 80595-73-9 ADRENALONE
    [Show full text]
  • Peptide Chemistry up to Its Present State
    Appendix In this Appendix biographical sketches are compiled of many scientists who have made notable contributions to the development of peptide chemistry up to its present state. We have tried to consider names mainly connected with important events during the earlier periods of peptide history, but could not include all authors mentioned in the text of this book. This is particularly true for the more recent decades when the number of peptide chemists and biologists increased to such an extent that their enumeration would have gone beyond the scope of this Appendix. 250 Appendix Plate 8. Emil Abderhalden (1877-1950), Photo Plate 9. S. Akabori Leopoldina, Halle J Plate 10. Ernst Bayer Plate 11. Karel Blaha (1926-1988) Appendix 251 Plate 12. Max Brenner Plate 13. Hans Brockmann (1903-1988) Plate 14. Victor Bruckner (1900- 1980) Plate 15. Pehr V. Edman (1916- 1977) 252 Appendix Plate 16. Lyman C. Craig (1906-1974) Plate 17. Vittorio Erspamer Plate 18. Joseph S. Fruton, Biochemist and Historian Appendix 253 Plate 19. Rolf Geiger (1923-1988) Plate 20. Wolfgang Konig Plate 21. Dorothy Hodgkins Plate. 22. Franz Hofmeister (1850-1922), (Fischer, biograph. Lexikon) 254 Appendix Plate 23. The picture shows the late Professor 1.E. Jorpes (r.j and Professor V. Mutt during their favorite pastime in the archipelago on the Baltic near Stockholm Plate 24. Ephraim Katchalski (Katzir) Plate 25. Abraham Patchornik Appendix 255 Plate 26. P.G. Katsoyannis Plate 27. George W. Kenner (1922-1978) Plate 28. Edger Lederer (1908- 1988) Plate 29. Hennann Leuchs (1879-1945) 256 Appendix Plate 30. Choh Hao Li (1913-1987) Plate 31.
    [Show full text]
  • Peptide Synthesis: Chemical Or Enzymatic
    Electronic Journal of Biotechnology ISSN: 0717-3458 Vol.10 No.2, Issue of April 15, 2007 © 2007 by Pontificia Universidad Católica de Valparaíso -- Chile Received June 6, 2006 / Accepted November 28, 2006 DOI: 10.2225/vol10-issue2-fulltext-13 REVIEW ARTICLE Peptide synthesis: chemical or enzymatic Fanny Guzmán Instituto de Biología Pontificia Universidad Católica de Valparaíso Avenida Brasil 2950 Valparaíso, Chile Fax: 56 32 212746 E-mail: [email protected] Sonia Barberis Facultad de Química, Bioquímica y Farmacia Universidad Nacional de San Luis Ejército de los Andes 950 (5700) San Luis, Argentina E-mail: [email protected] Andrés Illanes* Escuela de Ingeniería Bioquímica Pontificia Universidad Católica de Valparaíso Avenida Brasil 2147 Fax: 56 32 2273803 E-mail: [email protected] Financial support: This work was done within the framework of Project CYTED IV.22 Industrial Application of Proteolytic Enzymes from Higher Plants. Keywords: enzymatic synthesis, peptides, proteases, solid-phase synthesis. Abbreviations: CD: circular dichroism CLEC: cross linked enzyme crystals DDC: double dimer constructs ESI: electrospray ionization HOBT: hydroxybenzotriazole HPLC: high performance liquid hromatography KCS: kinetically controlled synthesis MALDI: matrix-assisted laser desorption ionization MAP: multiple antigen peptide system MS: mass spectrometry NMR: nuclear magnetic resonance SPS: solution phase synthesis SPPS: solid-phase peptide synthesis t-Boc: tert-butoxycarbonyl TCS: thermodynamically controlled synthesis TFA: trifluoroacetic acid Peptides are molecules of paramount importance in the medium, biocatalyst and substrate engineering, and fields of health care and nutrition. Several technologies recent advances and challenges in the field are analyzed. for their production are now available, among which Even though chemical synthesis is the most mature chemical and enzymatic synthesis are especially technology for peptide synthesis, lack of specificity and relevant.
    [Show full text]
  • INVESTIGATION INTO the CELLULAR ACTIONS of CARNOSINE and C-PEPTIDE Emma H
    Marshall Digital Scholar Theses, Dissertations and Capstones 2014 INVESTIGATION INTO THE CELLULAR ACTIONS OF CARNOSINE AND C-PEPTIDE Emma H. Gardner [email protected] Follow this and additional works at: http://mds.marshall.edu/etd Part of the Analytical Chemistry Commons, and the Biochemistry Commons Recommended Citation Gardner, Emma H., "INVESTIGATION INTO THE CELLULAR ACTIONS OF CARNOSINE AND C-PEPTIDE" (2014). Theses, Dissertations and Capstones. Paper 868. This Thesis is brought to you for free and open access by Marshall Digital Scholar. It has been accepted for inclusion in Theses, Dissertations and Capstones by an authorized administrator of Marshall Digital Scholar. For more information, please contact [email protected]. INVESTIGATION INTO THE CELLULAR ACTIONS OF CARNOSINE AND C-PEPTIDE A thesis submitted to the Graduate College of Marshall University In partial fulfillment of the requirements for the degree of Master of Science in Chemistry by Emma H. Gardner Approval by Dr. Leslie Frost, Committee Chairperson Dr. Derrick Kolling Dr. Menashi Cohenford Marshall University May 2014 Table of Contents List of Tables iv List of Figures v IRB Letter vii Abstracts viii 1. Investigation into the Cellular Actions of Carnosine 1 Introduction 1 Experimental Methods 11 Preparation of Carnosine Affinity Beads 11 Tissue Lysis 12 Protein Isolation 13 SDS PAGE Analysis of Isolated Proteins 13 Preparation of Tryptic Digests of Protein Samples from SDS-PAGE Bands 13 Analysis of Tryptic Digests of Proteins by MALDI-TOF Mass Spectrometry 14 Analysis of Tryptic Peptide Amino Acid Sequences by LC/ESI/MS 15 Determining the Effect of Carnosine on AGE Structure Formation 15 Sodium Borohydride Reduction 16 UV-VIS Absorbance Profile of Hemin 16 Results and Discussion 16 Identification of Carnosine Binding Proteins Isolated from Bovine Kidney Tissue 16 Identification of Carnosine Binding Proteins Isolated from Mouse Kidney Tissue 24 Effect of Carnosine on the Formation of AGEs 28 Analysis of Carnosine-Hemin Interactions 33 Future Work 34 References 36 2.
    [Show full text]
  • Two Human Metabolites Rescue a C. Elegans Model of Alzheimer’S
    ARTICLE https://doi.org/10.1038/s42003-021-02218-7 OPEN Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response ✉ Priyanka Joshi 1,3 , Michele Perni 1, Ryan Limbocker1,4, Benedetta Mannini 1, Sam Casford1, Sean Chia1, ✉ Johnny Habchi1, Johnathan Labbadia2, Christopher M. Dobson 1 & Michele Vendruscolo 1 Age-related changes in cellular metabolism can affect brain homeostasis, creating conditions that are permissive to the onset and progression of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Although the roles of metabolites have been exten- 1234567890():,; sively studied with regard to cellular signaling pathways, their effects on protein aggregation remain relatively unexplored. By computationally analysing the Human Metabolome Data- base, we identified two endogenous metabolites, carnosine and kynurenic acid, that inhibit the aggregation of the amyloid beta peptide (Aβ) and rescue a C. elegans model of Alzhei- mer’s disease. We found that these metabolites act by triggering a cytosolic unfolded protein response through the transcription factor HSF-1 and downstream chaperones HSP40/J- proteins DNJ-12 and DNJ-19. These results help rationalise previous observations regarding the possible anti-ageing benefits of these metabolites by providing a mechanism for their action. Taken together, our findings provide a link between metabolite homeostasis and protein homeostasis, which could inspire preventative interventions against neurodegen- erative disorders. 1 Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, UK. 2 Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, London, UK. 3Present address: The California Institute for Quantitative Biosciences (QB3-Berkeley), University of California, Berkeley, CA, USA.
    [Show full text]
  • Ehealth DSI [Ehdsi V2.2.2-OR] Ehealth DSI – Master Value Set
    MTC eHealth DSI [eHDSI v2.2.2-OR] eHealth DSI – Master Value Set Catalogue Responsible : eHDSI Solution Provider PublishDate : Wed Nov 08 16:16:10 CET 2017 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 1 of 490 MTC Table of Contents epSOSActiveIngredient 4 epSOSAdministrativeGender 148 epSOSAdverseEventType 149 epSOSAllergenNoDrugs 150 epSOSBloodGroup 155 epSOSBloodPressure 156 epSOSCodeNoMedication 157 epSOSCodeProb 158 epSOSConfidentiality 159 epSOSCountry 160 epSOSDisplayLabel 167 epSOSDocumentCode 170 epSOSDoseForm 171 epSOSHealthcareProfessionalRoles 184 epSOSIllnessesandDisorders 186 epSOSLanguage 448 epSOSMedicalDevices 458 epSOSNullFavor 461 epSOSPackage 462 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 2 of 490 MTC epSOSPersonalRelationship 464 epSOSPregnancyInformation 466 epSOSProcedures 467 epSOSReactionAllergy 470 epSOSResolutionOutcome 472 epSOSRoleClass 473 epSOSRouteofAdministration 474 epSOSSections 477 epSOSSeverity 478 epSOSSocialHistory 479 epSOSStatusCode 480 epSOSSubstitutionCode 481 epSOSTelecomAddress 482 epSOSTimingEvent 483 epSOSUnits 484 epSOSUnknownInformation 487 epSOSVaccine 488 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 3 of 490 MTC epSOSActiveIngredient epSOSActiveIngredient Value Set ID 1.3.6.1.4.1.12559.11.10.1.3.1.42.24 TRANSLATIONS Code System ID Code System Version Concept Code Description (FSN) 2.16.840.1.113883.6.73 2017-01 A ALIMENTARY TRACT AND METABOLISM 2.16.840.1.113883.6.73 2017-01
    [Show full text]
  • Bulk Drug Substances Under Evaluation for Section 503A
    Updated July 1, 2020 Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act Includes three categories of bulk drug substances: • Category 1: Bulk Drug Substances Under Evaluation • Category 2: Bulk Drug Substances that Raise Significant Safety Concerns • Category 3: Bulk Drug Substances Nominated Without Adequate Support Updates to Section 503A Categories • Removal from category 3 o Artesunate – This bulk drug substance is a component of an FDA-approved drug product (NDA 213036) and compounded drug products containing this substance may be eligible for the exemptions under section 503A of the FD&C Act pursuant to section 503A(b)(1)(A)(i)(II). This change will be effective immediately and will not have a waiting period. For more information, please see the Interim Policy on Compounding Using Bulk Drug Substances Under Section 503A and the final rule on bulk drug substances that can be used for compounding under section 503A, which became effective on March 21, 2019. 1 Updated July 1, 2020 503A Category 1 – Bulk Drug Substances Under Evaluation • 7 Keto Dehydroepiandrosterone • Glycyrrhizin • Acetyl L Carnitine/Acetyl-L- carnitine • Kojic Acid Hydrochloride • L-Citrulline • Alanyl-L-Glutamine • Melatonin • Aloe Vera/ Aloe Vera 200:1 Freeze Dried • Methylcobalamin • Alpha Lipoic Acid • Methylsulfonylmethane (MSM) • Artemisia/Artemisinin • Nettle leaf (Urtica dioica subsp. dioica leaf) • Astragalus Extract 10:1 • Nicotinamide Adenine Dinucleotide (NAD) • Boswellia • Nicotinamide
    [Show full text]
  • Potentially Explosive Chemicals*
    Potentially Explosive Chemicals* Chemical Name CAS # Not 1,1’-Diazoaminonaphthalene Assigned 1,1-Dinitroethane 000600-40-8 1,2,4-Butanetriol trinitrate 006659-60-5 1,2-Diazidoethane 000629-13-0 1,3,5-trimethyl-2,4,6-trinitrobenzene 000602-96-0 1,3-Diazopropane 005239-06-5 Not 1,3-Dinitro-4,5-dinitrosobenzene Assigned Not 1,3-dinitro-5,5-dimethyl hydantoin Assigned Not 1,4-Dinitro-1,1,4,4-tetramethylolbutanetetranitrate Assigned Not 1,7-Octadiene-3,5-Diyne-1,8-Dimethoxy-9-Octadecynoic acid Assigned 1,8 –dihydroxy 2,4,5,7-tetranitroanthraquinone 000517-92-0 Not 1,9-Dinitroxy pentamethylene-2,4,6,8-tetramine Assigned 1-Bromo-3-nitrobenzene 000585-79-5 Not 2,2',4,4',6,6'-Hexanitro-3,3'-dihydroxyazobenzene Assigned 2,2-di-(4,4,-di-tert-butylperoxycyclohexyl)propane 001705-60-8 2,2-Dinitrostilbene 006275-02-1 2,3,4,6- tetranitrophenol 000641-16-7 Not 2,3,4,6-tetranitrophenyl methyl nitramine Assigned Not 2,3,4,6-tetranitrophenyl nitramine Assigned Not 2,3,5,6- tetranitroso nitrobenzene Assigned Not 2,3,5,6- tetranitroso-1,4-dinitrobenzene Assigned 2,4,6-Trinitro-1,3,5-triazo benzene 029306-57-8 Not 2,4,6-trinitro-1,3-diazabenzene Assigned Not 2,4,6-Trinitrophenyl trimethylol methyl nitramine trinitrate Assigned Not 2,4,6-Trinitroso-3-methyl nitraminoanisole Assigned 2,4-Dinitro-1,3,5-trimethyl-benzene 000608-50-4 2,4-Dinitrophenylhydrazine 000119-26-6 2,4-Dinitroresorcinol 000519-44-8 2,5-dimethyl-2,5-diydroperoxy hexane 2-Nitro-2-methylpropanol nitrate 024884-69-3 3,5-Dinitrosalicylic acid 000609-99-4 Not 3-Azido-1,2-propylene glycol dinitrate
    [Show full text]
  • Pharmaceutical Appendix to the Tariff Schedule 2
    Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9
    [Show full text]
  • Prediction of the Crystalline Densities of Aliphatic Nitrates by Quantum Chemistry Methods
    Central European Journal of Energetic Materials ISSN 1733-7178; e-ISSN 2353-1843 Copyright © 2019 Sieć Badawcza Łukasiewicz – Institute of Industrial Organic Chemistry, Poland Cent. Eur. J. Energ. Mater. 2019, 16(3): 412-432; DOI 10.22211/cejem/112306 Article is available in PDF-format, in colour, at: http://www.wydawnictwa.ipo.waw.pl/cejem/Vol-16-Number3-2019/CEJEM_00978.pdf Article is available under the Creative Commons Attribution-Noncommercial-NoDerivs 3.0 license CC BY-NC-ND 3.0. Research paper Prediction of the Crystalline Densities of Aliphatic Nitrates by Quantum Chemistry Methods Guixiang Wang,* Yimin Xu, Chuang Xue, Zhiyuan Ding, Yan Liu, Hui Liu, Xuedong Gong** Computation Institute for Molecules and Materials, Department of Chemistry, Nanjing University of Science and Technology, Nanjing 210094, China E-mails: * [email protected]; ** [email protected] Abstract: Crystal density is a basic and important parameter for predicting the detonation performance of explosives, and nitrate esters are a type of compound widely used in the military context. In this study, thirty-one aliphatic nitrates were investigated using the density functional theory method (B3LYP) in combination with six basis sets (3-21G, 6-31G, 6-31G*, 6-31G**, 6-311G* and 6-31+G**) and the semiempirical molecular orbital method (PM3). Based on the geometric optimizations at various theoretical levels, the molecular volumes and densities were calculated. Compared with the available experimental data, the densities calculated by various methods are all overestimated, and the errors of the PM3 and B3LYP/3-21G methods are larger than those of other methods. Considering the results and the computer resources required by the calculations, the B3LYP/6-31G* method is recommended for predicting the crystalline densities of organic nitrates using a fitting equation.
    [Show full text]
  • Compositions Comprising Nebivolol
    (19) TZZ ZZ__T (11) EP 2 808 015 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 03.12.2014 Bulletin 2014/49 A61K 31/34 (2006.01) A61K 31/502 (2006.01) A61K 31/353 (2006.01) A61P 9/00 (2006.01) (21) Application number: 14002458.9 (22) Date of filing: 16.11.2005 (84) Designated Contracting States: • O’Donnell, John AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Morgantown, WV 26505 (US) HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI • Bottini, Peter Bruce SK TR Morgantown, WV 26505 (US) • Mason, Preston (30) Priority: 31.05.2005 US 141235 Morgantown, WV 26504 (US) 10.11.2005 US 272562 • Shaw, Andrew Preston 15.11.2005 US 273992 Morgantown, WV 26504 (US) (62) Document number(s) of the earlier application(s) in (74) Representative: Samson & Partner accordance with Art. 76 EPC: Widenmayerstraße 5 09015249.7 / 2 174 658 80538 München (DE) 05848185.4 / 1 890 691 Remarks: (71) Applicant: MYLAN LABORATORIES, INC This application was filed on 16-07-2014 as a Morgantown, NV 26504 (US) divisional application to the application mentioned under INID code 62. (72) Inventors: • Davis, Eric Morgantown, WV 26508 (US) (54) Compositions comprising nebivolol (57) The active ingredients of the pharmaceutical composition described consist of nebivolol, one or more ACE inhibitors and one or more ARB. EP 2 808 015 A1 Printed by Jouve, 75001 PARIS (FR) EP 2 808 015 A1 Description [0001] This application is a continuation-in-part of application Ser.
    [Show full text]
  • Brain Peptides As Neurotransmitters (2)
    as normal faults in Fig. 3 are actually complex 26. R. B. Herrnann and J. A. Canas, Bull. Seismol. 30. See, for example, L. R. Sykes, Rev. Geophys. zones with multiple offsets. Some of the faults Soc. Am. 68, 1095 (1978); R. B. Herrmann, J. Space Phys. 16, 621 (1979). can be interpreted as high-angle reverse faults Geophys. Res. 84, 3543 (1979). 31. W. Stauder et al., Cent. Miss. Val. Earthquake (line S-6). 27. R. R. Heinrich, Bull. Seismol. Soc. Am. 31, 187 Bull. 19 (1979). 23. R. G. Stearns, U.S. Nucl. Regul. Comm. Rep. (1941). 32. We thank R. E. Anderson, W. H. Diment, and NUREGICR-0874 (1979). 28. T. G. Hildenbrand, personal communication. 0. W. Nuttli, who reviewed the manuscript and- 24. W. M. Caplan, Arkansas Div. Geol. Bull. 20 29. The research well near line S-10 encountered suggested improvements. Appreciation is ex- (1954). highly fractured and altered Paleozoic rocks. tended to the U.S. Nuclear Regulatory Commis- 25. T. C. Buschbach, U.S. Nucl. Regul. Comm. The mineralogy and geochemistry of the rocks sion for providing the funds for the research Rep. NUREGICR-0450 (1978). suggests a nearby igneous body. well. addition, analgesia that follows electrical stimulation of the brainstem of rats could be partially reversed by the opiate antag- onist naloxone, an indication that a mor- phine-like substance was being released Brain Peptides as Neurotransmitters (2). To identify the postulated morphine- like factor two approaches were taken. Solomon H. Snyder Hughes (3) showed that brain extracts can mimic morphine's effects on electri- cally induced contractions of smooth muscle in a fashion that is blocked by It is generally agreed that information represent only 10 percent or less of the naloxone.
    [Show full text]