(12) Patent Application Publication (10) Pub. No.: US 2002/0150616A1 VANDECRUYS (43) Pub
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The 2021 List of Pharmacological Classes of Doping Agents and Doping Methods
BGBl. III - Ausgegeben am 8. Jänner 2021 - Nr. 1 1 von 23 The 2021 list of pharmacological classes of doping agents and doping methods www.ris.bka.gv.at BGBl. III - Ausgegeben am 8. Jänner 2021 - Nr. 1 2 von 23 www.ris.bka.gv.at BGBl. III - Ausgegeben am 8. Jänner 2021 - Nr. 1 3 von 23 THE 2021 PROHIBITED LIST WORLD ANTI-DOPING CODE DATE OF ENTRY INTO FORCE 1 January 2021 Introduction The Prohibited List is a mandatory International Standard as part of the World Anti-Doping Program. The List is updated annually following an extensive consultation process facilitated by WADA. The effective date of the List is 1 January 2021. The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail. Below are some terms used in this List of Prohibited Substances and Prohibited Methods. Prohibited In-Competition Subject to a different period having been approved by WADA for a given sport, the In- Competition period shall in principle be the period commencing just before midnight (at 11:59 p.m.) on the day before a Competition in which the Athlete is scheduled to participate until the end of the Competition and the Sample collection process. Prohibited at all times This means that the substance or method is prohibited In- and Out-of-Competition as defined in the Code. Specified and non-Specified As per Article 4.2.2 of the World Anti-Doping Code, “for purposes of the application of Article 10, all Prohibited Substances shall be Specified Substances except as identified on the Prohibited List. -
The 2006 Prohibited List International Standard
The World Anti-Doping Code THE 2006 PROHIBITED LIST INTERNATIONAL STANDARD The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail. This List shall come into effect on 1 January 2006. THE 2006 PROHIBITED LIST WORLD ANTI-DOPING CODE Valid 1 January 2006 The use of any drug should be limited to medically justified indications SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) PROHIBITED SUBSTANCES S1. ANABOLIC AGENTS Anabolic agents are prohibited. 1. Anabolic Androgenic Steroids (AAS) a. Exogenous* AAS, including: 1-androstendiol (5α-androst-1-ene-3β,17β-diol ); 1-androstendione (5α- androst-1-ene-3,17-dione); bolandiol (19-norandrostenediol); bolasterone; boldenone; boldione (androsta-1,4-diene-3,17-dione); calusterone; clostebol; danazol (17α-ethynyl-17β-hydroxyandrost-4-eno[2,3-d]isoxazole); dehydrochlormethyltestosterone (4-chloro-17β-hydroxy-17α-methylandrosta- 1,4-dien-3-one); desoxymethyltestosterone (17α-methyl-5α-androst-2-en- 17β-ol); drostanolone; ethylestrenol (19-nor-17α-pregn-4-en-17-ol); fluoxymesterone; formebolone; furazabol (17β-hydroxy-17α-methyl-5α- androstano[2,3-c]-furazan); gestrinone; 4-hydroxytestosterone (4,17β-dihydroxyandrost-4-en-3-one); mestanolone; mesterolone; metenolone; methandienone (17β-hydroxy-17α- methylandrosta-1,4-dien-3-one); methandriol; methasterone (2α, 17α- dimethyl-5α-androstane-3-one-17β-ol); methyldienolone -
UFC PROHIBITED LIST Effective June 1, 2021 the UFC PROHIBITED LIST
UFC PROHIBITED LIST Effective June 1, 2021 THE UFC PROHIBITED LIST UFC PROHIBITED LIST Effective June 1, 2021 PART 1. Except as provided otherwise in PART 2 below, the UFC Prohibited List shall incorporate the most current Prohibited List published by WADA, as well as any WADA Technical Documents establishing decision limits or reporting levels, and, unless otherwise modified by the UFC Prohibited List or the UFC Anti-Doping Policy, Prohibited Substances, Prohibited Methods, Specified or Non-Specified Substances and Specified or Non-Specified Methods shall be as identified as such on the WADA Prohibited List or WADA Technical Documents. PART 2. Notwithstanding the WADA Prohibited List and any otherwise applicable WADA Technical Documents, the following modifications shall be in full force and effect: 1. Decision Concentration Levels. Adverse Analytical Findings reported at a concentration below the following Decision Concentration Levels shall be managed by USADA as Atypical Findings. • Cannabinoids: natural or synthetic delta-9-tetrahydrocannabinol (THC) or Cannabimimetics (e.g., “Spice,” JWH-018, JWH-073, HU-210): any level • Clomiphene: 0.1 ng/mL1 • Dehydrochloromethyltestosterone (DHCMT) long-term metabolite (M3): 0.1 ng/mL • Selective Androgen Receptor Modulators (SARMs): 0.1 ng/mL2 • GW-1516 (GW-501516) metabolites: 0.1 ng/mL • Epitrenbolone (Trenbolone metabolite): 0.2 ng/mL 2. SARMs/GW-1516: Adverse Analytical Findings reported at a concentration at or above the applicable Decision Concentration Level but under 1 ng/mL shall be managed by USADA as Specified Substances. 3. Higenamine: Higenamine shall be a Prohibited Substance under the UFC Anti-Doping Policy only In-Competition (and not Out-of- Competition). -
(12) United States Patent (10) Patent No.: US 9,636.405 B2 Tamarkin Et Al
USOO9636405B2 (12) United States Patent (10) Patent No.: US 9,636.405 B2 Tamarkin et al. (45) Date of Patent: May 2, 2017 (54) FOAMABLE VEHICLE AND (56) References Cited PHARMACEUTICAL COMPOSITIONS U.S. PATENT DOCUMENTS THEREOF M (71) Applicant: Foamix Pharmaceuticals Ltd., 1,159,250 A 1 1/1915 Moulton Rehovot (IL) 1,666,684 A 4, 1928 Carstens 1924,972 A 8, 1933 Beckert (72) Inventors: Dov Tamarkin, Maccabim (IL); Doron 2,085,733. A T. 1937 Bird Friedman, Karmei Yosef (IL); Meir 33 A 1683 Sk Eini, Ness Ziona (IL); Alex Besonov, 2,586.287- 4 A 2/1952 AppersonO Rehovot (IL) 2,617,754. A 1 1/1952 Neely 2,767,712 A 10, 1956 Waterman (73) Assignee: EMY PHARMACEUTICALs 2.968,628 A 1/1961 Reed ... Rehovot (IL) 3,004,894. A 10/1961 Johnson et al. (*) Notice: Subject to any disclaimer, the term of this 3,062,715. A 1 1/1962 Reese et al. tent is extended or adiusted under 35 3,067,784. A 12/1962 Gorman pa 3,092.255. A 6/1963 Hohman U.S.C. 154(b) by 37 days. 3,092,555 A 6/1963 Horn 3,141,821 A 7, 1964 Compeau (21) Appl. No.: 13/793,893 3,142,420 A 7/1964 Gawthrop (22) Filed: Mar. 11, 2013 3,144,386 A 8/1964 Brightenback O O 3,149,543 A 9/1964 Naab (65) Prior Publication Data 3,154,075 A 10, 1964 Weckesser US 2013/0189193 A1 Jul 25, 2013 3,178,352. -
2008 Prohibited List
The World Anti-Doping Code THE 2008 PROHIBITED LIST INTERNATIONAL STANDARD The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail. This List shall come into effect on 1 January 2008 The Prohibited List 2008 September 22, 2007 THE 2008 PROHIBITED LIST WORLD ANTI-DOPING CODE Valid 1 January 2008 The use of any drug should be limited to medically justified indications SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) PROHIBITED SUBSTANCES S1. ANABOLIC AGENTS Anabolic agents are prohibited. 1. Anabolic Androgenic Steroids (AAS) a. Exogenous* AAS, including: 1-androstendiol (5α-androst-1-ene-3β,17β-diol ); 1-androstendione (5α- androst-1-ene-3,17-dione); bolandiol (19-norandrostenediol); bolasterone; boldenone; boldione (androsta-1,4-diene-3,17-dione); calusterone; clostebol; danazol (17α-ethynyl-17β-hydroxyandrost-4-eno[2,3-d]isoxazole); dehydrochlormethyltestosterone (4-chloro-17β-hydroxy-17α-methylandrosta- 1,4-dien-3-one); desoxymethyltestosterone (17α-methyl-5α-androst-2-en- 17β-ol); drostanolone; ethylestrenol (19-nor-17α-pregn-4-en-17-ol); fluoxymesterone; formebolone; furazabol (17β-hydroxy-17α-methyl-5α- androstano[2,3-c]-furazan); gestrinone; 4-hydroxytestosterone (4,17β- dihydroxyandrost-4-en-3-one); mestanolone; mesterolone; metenolone; methandienone (17β-hydroxy-17α-methylandrosta-1,4-dien-3-one); methandriol; methasterone (2α, 17α-dimethyl-5α-androstane-3-one-17β-ol); -
Idiopathic Orthostatic Hypotension, Midodrine, and Anaesthesia
499 Idiopathic orthostatic hypotension, mido- P.J. Osborne MD, L.W. Lee MD drine, and anaesthesia A patient with idiopathic orthostatic hypotension receiving Idiopathic orthostatic hypotension (IOH), which was first chronic oral midodrine therapy required amwsthesia for coro- described in 1925, ~ manifests as postural hypotension, nary arter3., bypass grafting. A perioperative infusioo of phenyl- syncope, fixed heart rate, defective sweating, nocturia ephrine was substituted ,/'or midodrine, an alpha-2 agonist, and impotence. Urinary or faecal incontinence or consti- enabling hypotension resulting from low systemic vascular pation may also occur. Inappropriate cardiovascular resistance to be controlled easily. Anticipated adrenergic reflexes2 predispose to haemodynamic instability. Treat- receptor denert,ation hypersensitivi O, was noted. The only ment is symptomatic, and includes head-up body tilt at significant perioperative problem was one episode of ~Tncope night, elastic stockings, 9 o~-fludroconisone and mido- from orthostatic hypotension during the reambulation period. drine 3 (Gutron | - Chemie Linz AG, Linz, Austria), an oral oL-adrenergic agonist in use in Europe, but an Un patient atteint d'hypolension or/hostatique idiopathique investigational drug in North America. The anaesthetic recevant un traitement oral chronique tl la midodrine a requis management of patients with autonomic dysfunction has I'anesthe;sie pour pontage aortocoronarien. Une perfusion been described, 4-9 but this is the first report of a patient pEriop~ratoire de phEnyl~phrine fut substitude ti la midodrine, with IOH receiving chronic midodrine therapy undergo- un agoniste alpha 2, a permis ~ I'hypotension r~sultant d'une ing cardiac surgery. r~sistance vasculaire syst~mique basse d'e;tre contr~l(e facile- ment. -
View PDF Version
Green Chemistry View Article Online PAPER View Journal | View Issue Synthesis of pharmaceutical drugs from cardanol derived from cashew nut shell liquid†‡ Cite this: Green Chem., 2019, 21, 1043 Yiping Shi, Paul C. J. Kamer § and David J. Cole-Hamilton * Cardanol from cashew nut shell liquid extracted from cashew nut shells was successfully converted into various useful pharmaceutical drugs, such as norfenefrine, rac-phenylephrine, etilefrine and fenoprofene. 3-Vinylphenol, the key intermediate for the synthesis of these drugs, was synthesised from cardanol by ethenolysis to 3-non-8-enylphenol followed by isomerising ethenolysis. The metathesis reaction worked very well using DCM, but the greener solvent, 2-methyl tetrahydrofuran, also gave very similar results. Hydroxyamination of 3-vinylphenol with an iron porphyrin catalyst afforded norfenefrine in over 70% yield. Methylation and ethylation of norfenefrine afforded rac-phenylephrine and etilefrine respectively. A sequence of C–O coupling, isomerising metathesis and selective methoxycarbonylation afforded feno- profene in good yield. A comparison of the routes described in this paper with some standard literature Creative Commons Attribution 3.0 Unported Licence. syntheses of 3-vinylphenol and of the drug molecules shows significant environmental advantages in terms of precursors, yields, number of steps, conditions and the use of catalysts. The Atom Economy of our processes is generally similar or significantly superior to those of the literature processes mainly Received 7th December 2018, because the side products produced during synthesis of 3-vinylphenol (1-octeme, 1,4-cyclohexadiene Accepted 15th January 2019 and propene) are easily separable and of commercial value, especially as they are bio-derived. -
Plasma Catecholamines During Activation of the Sympathetic Nervous System in a Patient with Shy-Drager Syndrome
Journal of J. Neurol. 224, 125-131 (1980) Neurology © by Springer-Verlag 1980 Plasma Cateeholamines During Activation of the Sympathetic Nervous System in a Patient with Shy-Drager Syndrome G. Gross ~*, M. Nagel-Hiemke I, and K.-H. Krause 2 Pharmakologisches Institut des Universitäts-Klinikums, Hufelandstr. 55, D-4300 Essen : Neurologische Universitätsklinik, Voßstr. 2, D-6900 Heidelberg, Federal Republic of Germany Summary. Plasma catecholamines and circulation parameters were studied in a patient with a Shy-Drager syndrome. Basal values of free noradrenaline and dopamine were within the normal range, whereas the adrenaline level was de- creased. The response of plasma catecholamines to different kinds of physical activity was pathological. The inability to maintain elevated catecholamine levels during prolonged activity corresponded to impaired circulatory regu- lation and may provide an additional tool for diagnosis and monitoring of the Shy-Drager syndrome. Key words: Shy-Drager syndrome - Idiopathic orthostatic hypotension - Plasma catecholamines - Circulatory regulation. Zusammenfassung. Bei einer Patientin mit Shy-Drager-Syndrom wurden Plasmakatecholamine und Kreislaufparameter untersucht. Die basalen Werte an freiem Noradrenalin und Dopamin waren im Normbereich, Adrenalin erniedrigt. Die Reaktion der Plasmakatecholamine auf verschiedene Arten körperlicher Belastung war deutlich pathologisch. Die Unfähigkeit, die Plasmakatecholamine vor allem während längerer Aktivität auf erhöhtem Niveau zu halten, entsprach der beeinträchtigten -
Glycoprotein Biosynthesis Carol Lambadarios, Cetra Hastings, J
Steroid effects on human endometrial glycoprotein biosynthesis Carol Lambadarios, Cetra Hastings, J. Abo-Darub and I. D. Cooke Department of Obstetrics and Gynaecology, University of Sheffield, Jessop Hospitalfor Women, Leavygreave Road, Sheffield 53 IRE, U.K. Summary. Human endometrium from the secretory phase of the menstrual cycle was incubated with 3H- and 14C-labelled glucosamine and [3H]leucine. Incorporation into secreted extracellular glycoprotein and accumulation of the label into the micro- somal fraction were measured. When oestradiol or progesterone were added to the medium, medroxyprogesterone acetate (MPA), ethynodiol diacetate and chlormadi- none acetate reduced incorporation of glucosamine and MPA reduced incorporation of leucine into glycoprotein. MPA reduced the amount of glucosamine in the micro- somal fraction and also had an effect on amino acid transport within the endometrial cells, as indicated by intracellular \g=m\-aminoisobutyricacid space measurements. These results and the ratios of 3H and 14C in the microsomal fraction and secreted protein suggest that MPA has a primary effect in decreasing amino sugar incorporation and a secondary effect in reducing amino acid incorporation into glycoprotein. Introduction The histology of human endometrial glandular cell secretion has been described by Noyes, Hertig & Rock (1950). During the secretory phase the Golgi complexes are greatly developed and the distended endoplasmic reticulum contains glycogen and glycoprotein (Wynn & Harris, 1967; Wynn & Woolley, 1967). Pincus, Rock & Garcia (1958) reported alterations in endometrial histology in response to synthetic progestagens. Flowers, Wilborn & Enger (1974) studied the ultrastructure of the endometrium after treatment with quingestanol acetate for 3 months and observed that many aspects of protein synthesis were affected and that, despite ovulation, subnuclear vacuolation did not occur. -
Studies of Cancer in Experimental Animals
ORAL CONTRACEPTIVES, COMBINED 201 3. Studies of Cancer in Experimental Animals In this section, only relevant studies on oestrogens and progestogens alone and in combination that were published subsequent to or not included in Volume 21 of the IARC Monographs (IARC, 1979) are reviewed in detail. Studies reviewed previously are summarized briefly. 3.1 Oestrogen–progestogen combinations 3.1.1 Studies reviewed previously Mouse The results of studies reviewed previously (Committee on Safety of Medicines, 1972; IARC, 1979) on the carcinogenicity of combinations of oestrogens and proges- togens in mice are as follows: Chlormadinone acetate in combination with mestranol tested by oral administration to mice caused an increased incidence of pituitary adenomas in animals of each sex. Oral administration of chlormadinone acetate in combination with ethinyloestradiol to mice resulted in an increased incidence of mammary tumours in intact and castrated males. After oral administration of ethynodiol diacetate and mestranol to mice, increased incidences of pituitary adenomas were observed in animals of each sex. The combination of ethynodiol diacetate plus ethinyloestradiol, tested by oral administration to mice, increased the incidences of pituitary adenomas in animals of each sex and of malignant tumours of connective tissues of the uterus. Lynoestrenol in combination with mestranol was tested in mice by oral administration. A slight, nonsignificant increase in the incidence of malignant mammary tumours was observed in females which was greater than that caused by lynoestrenol or mestranol alone. The combination of megestrol acetate plus ethinyloestradiol, tested by oral adminis- tration to mice, caused an increased incidence of malignant mammary tumours in animals of each sex. -
Large-Scale Phenotypic Drug Screen Identifies Neuroprotectants In
bioRxiv preprint doi: https://doi.org/10.1101/2020.03.26.010009; this version posted March 28, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa Liyun Zhang1, Conan Chen1,2, Jie Fu3, Brendan Lilley1, Cynthia Berlinicke1, Baranda Hansen1,4, Ding Ding5, Guohua Wang1,6, Tao Wang3,7,8, Daniel Shou3, Ying Ye3, Meera T. Saxena1, Kelsi R. Hall9, Abigail V. Sharrock9, Carlene Brandon10, Joong Sup Shim11, Justin Hanes3, Hongkai Ji5, Jun O. Liu12,13, Jiang Qian1, David F. Ackerley9, Baerbel Rohrer10, Donald J. Zack1, 3,14,15,16, and Jeff S. Mumm1,3,15,16 1Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA 2Current address: University of Colorado Anschutz Medical Campus 3The Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA 4Current address: St. Jude Children’s Research Hospital, Memphis, TN 5Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA 6Current address: School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China 7School of Chemistry, Xuzhou College of Industrial Technology, Xuzhou, China 8College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing, China 9School of Biological -
Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0