NEW ZEALAND CONSUMER MEDICINE INFORMATION TMP Trimethoprim 300 mg tablets

Tell your doctor if you are What is in this leaflet Before you take TMP pregnant or plan to become pregnant or are breast-feeding. Please read this leaflet carefully Your doctor can discuss with you When you must not take the risks and benefits involved. before you start taking TMP. it If you have not told your doctor This leaflet answers some common Do not take TMP if you have an about any of the above, tell them questions about TMP. allergy to: before you start taking TMP. It does not contain all the available • any medicine containing information. It does not take the trimethoprim Taking other medicines place of talking to your doctor or • any of the ingredients listed pharmacist. at the end of this leaflet. Tell your doctor or pharmacist if you are taking any other medicines, including medicines All medicines have risks and Some of the symptoms of an that you buy without a benefits. Your doctor has weighed allergic reaction may include: prescription from your pharmacy, the risks of you taking TMP against shortness of breath; wheezing supermarket or health food shop. the benefits they expect it will have or difficulty breathing; swelling for you. of the face, lips, tongue or other parts of the body; rash, itching You should also tell any health professional who is prescribing a If you have any concerns about or hives on the skin. new medication for you that you are taking this medicine, ask your taking TMP. doctor or pharmacist. Do not take TMP if: • you have or have had Some medicines may interfere with Keep this leaflet with the severe blood disorders or TMP . These include: medicine. You may need to read it anaemia again. • you have severe kidney • pyrimethamine, a medicine problems used to prevent malaria What TMP is used • warfarin, a medicine used Do not take this medicine after to prevent blood clots for the expiry date printed on the • methotrexate, a medicine pack or if the packaging is torn or used to treat painful swollen shows signs of tampering. TMP is used to treat and prevent joints and some types of If it has expired or is damaged, infections of the urinary tract caused cancer return it to your pharmacist for by bacteria. • phenytoin, a medicine used disposal. to control epilepsy (fits or TMP contains the active ingredient seizures) If you are not sure whether you trimethoprim. It belongs to a group • digoxin, a medicine used to should start taking this medicine, of medicines known as antibiotics. It treat heart failure or to talk to your doctor. works by stopping the growth of the control a fast irregular heart bacteria that is causing your beat infection. Before you start to take • procainamide, a medicine it used to correct an irregular Your doctor may have prescribed heart beat or to slow an this medicine for another reason. Tell your doctor if you have overactive heart beat allergies to any other medicines, • amantadine, a medicine Ask your doctor if you have any foods, preservatives or dyes. used to treat Parkinson’s questions about why this disease medicine has been prescribed for Tell your doctor if you have or • rifampicin, an antibiotic you. have had any of the following • cyclosporin, a medicine medical conditions: used to help prevent organ This medicine is available only with • folate deficiency transplant rejection or to a doctor’s prescription. • kidney problems treat certain problems with • liver problems the immune system • blood disorders

Page 1 of 4 • certain blood pressure The elderly and people with kidney medications that can problems may need to take a While you are taking increase potassium levels smaller dose. in the blood TMP • zidovudine, zalcitabine and Some people may need to take lamivudine, medicines used folate supplements while taking Things you must do to treat HIV TMP. These people may include the • dapsone, a medicine used elderly, people with folate deficiency If you are about to be started on to treat inflamed skin and people taking certain any new medicines, tell your disorders medicines. doctor and pharmacist that you are taking TMP. • medicines that are used to increase the urine Your doctor may tell you to take Tell any other doctors, dentists production different doses to these. If so, follow and pharmacists who treat you • medicines that are their instructions. that you are taking this medicine. decreasing the blood cell production. How to take it If you are going to have surgery, tell the surgeon or anaesthetist These medicines may be affected Swallow the tablets whole with a that you are taking TMP. by TMP or may affect how well it full glass of water. It may affect other medicines used works. You may need different during surgery. amounts of your medicines, or you When to take it may need to take different Tell your doctor if you develop a medicines. Take your medicine at about the same time each day. skin rash or hives while taking Taking it at the same time each day TMP. Your doctor and pharmacist have will have the best effect. It will also more information on medicines to help you remember when to take it. If you become pregnant while be careful with or avoid while taking taking this medicine, tell your this medicine. TMP tablets are best taken before doctor immediately. bedtime. If you are about to have any How to take TMP It does not matter if you take this blood tests, tell your doctor that medicine with or without food. you are taking this medicine. Follow all directions given to you However, taking TMP with food will It may interfere with the results of by your doctor or pharmacist help reduce the chance of a some tests. carefully. stomach upset. They may differ from the information Keep all of your doctor’s contained in this leaflet. How long to take it appointments so that your progress can be checked. If you do not understand the Continue taking your medicine Your doctor may do some tests instructions on the label, ask for as long as your doctor tells from time to time to make sure the your doctor or pharmacist for you. medicine is working and to prevent help. It is important to keep taking your unwanted side effects. medicine even if you feel well. How much to take Things you must not do Check with your doctor if you are Your doctor will tell you how much unsure how long you should take Do not take TMP to treat any TMP you need to take each day. It TMP for. other complaints unless your is important that you take TMP as doctor tells you to. directed by your doctor. Do not take If you forget to take it more than the recommended dose. Do not give your medicine to If you forget to take a dose, skip anyone else, even if they have The usual daily dose of TMP to treat the dose you missed and take the same condition as you. urinary tract infections in adults and your next dose when you are children over 12 years is 300 mg meant to. Do not stop taking your medicine once daily. or lower the dosage without Do not take a double dose to checking with your doctor. The usual daily dose of TMP to make up for the dose that you If you stop taking it suddenly, your prevent urinary tract infections in missed. condition may worsen. adults and children over 12 years is If possible, your doctor will gradually 100 mg once daily. If you are not sure what to do, reduce the amount you take each ask your doctor or pharmacist. day before stopping the medicine For children under 12 years, the completely. dose of TMP will depend on the If you have trouble remembering to child’s age and weight. take your medicine, ask your pharmacist for some hints.

Page 2 of 4 Things to be careful of Ask your doctor or pharmacist to • feelings of deep sadness answer any questions you may and unworthiness Be careful driving or operating have. (depression) machinery until you know how • seeing or feeling things that TMP affects you. Tell your doctor or pharmacist if are not there This medicine may cause dizziness, you notice any of the following (hallucinations) tiredness or drowsiness in some and they worry you: • confusion, nervousness, people. If you have any of these feeling anxious • headache symptoms, do not drive, operate • agitation • nausea, vomiting, diarrhoea machinery or do anything else that • abnormal uncontrolled • constipation could be dangerous. Children movements including should be careful when riding • loss of appetite muscle twitching or spasms bicycles or climbing trees. • upset stomach • clumsiness and lack of cough • coordination, affecting • difficulty sleeping, balance and manner of In case of overdose nightmares walking, limb or eye • dizziness, sleepiness, movement and/or speech If you take too much drowsiness • shaking • weight loss (overdose) • pain and/or swelling in the • ringing, hissing, whistling, arms or legs Immediately telephone your buzzing or persisting noise • blurred vision, redness of doctor or the National Poisons in the ears the eye, eye pain, Information Centre (telephone • nosebleeds increased sensitivity to light 0800 POISON or 0800 764 766) or • increased sensitivity to the • stiff neck that may occur go to Accident and Emergency at sun with extreme sensitivity to your nearest hospital, if you think • joint or muscle pain bright light that you or anyone else may have • tingling or numbness of the • skin blisters that might taken too much TMP. Do this hands or feet come with bleeding in the even if there are no signs of • signs of low blood sugar lips, eyes, mouth, nose and discomfort or poisoning. You may levels like sweating, genitals need urgent medical attention. weakness, hunger, • blood in the urine dizziness, trembling, Symptoms of an overdose may headache, flushing or The above list includes serious side include nausea, vomiting, dizziness, paleness, numbness, effects that may require medical headaches, mental depression, having a fast and pounding attention. confusion, tiredness, being short of heart beat breath when exercising, looking • fainting If any of the following happen, pale, fever, chills, sore throat, tell your doctor immediately or mouth ulcers, bleeding or bruising Tell your doctor as soon as go to Accident and Emergency at more easily than normal, possible if you notice any of the your nearest hospital: nosebleeds. following: • swelling of the face, lips, • any skin reaction, redness, mouth, tongue or other Side effects itching, swelling, flaking, body parts peeling or blistering of the • shortness of breath, skin (e.g. skin rash, 'hives', wheezing or difficulty Tell your doctor or pharmacist as spots, or blisters) soon as possible if you do not breathing/swallowing • sore mouth, mouth ulcers • seizures, fits, convulsions feel well while you are taking and cold sores TMP. • yellowing of the skin and/or • tiredness This medicine helps most people eyes • being short of breath when with urinary infections, but it may exercising have unwanted side effects in a few The above list includes very serious • looking pale people. side effects. You may need urgent • signs of frequent infections medical attention or hospitalisation. such as fever, chills, sore If you are elderly you may have an throat or mouth ulcers increased chance of getting side Tell your doctor or pharmacist if effects. • bruising or bleeding more you notice anything that is easily than normal making you feel unwell. All medicines can have side • purple or red-brown spots effects. Sometimes they are visible through the skin Other side effects not listed above serious, most of the time they are • watery and severe may also occur in some people. Tell not. You may need medical diarrhoea which may also your doctor if you notice any other treatment if you get some of the be bloody effects. side effects.

Page 3 of 4 Some of these side effects (for Inactive ingredient(s): example, changes in your blood TMP also contains: sugar levels, blood pressureor white blood cells) can only be found when • lactose your doctor does tests from time to • magnesium stearate time to check your progress. • povidone • sodium starch glycollate Do not be alarmed by these lists • purified talc. of possible side effects. You may not experience any of them. This medicine does not contain gluten. After taking TMP If you want to know Storage more Keep your tablets in the bottle until it is time to take them. Should you have any questions If you take the tablets out of the regarding this product, please bottle they may not keep well. contact your pharmacist or doctor.

Keep your tablets in a cool dry Who supplies this place where the temperature stays below 25°C. medicine TMP is supplied in New Zealand by: Do not store TMP or any other medicine in the bathroom or near a Mylan New Zealand Ltd, sink. Do not leave it on a window sill PO Box 11183, or in the car. Ellerslie, Heat and dampness can destroy Auckland some medicines. NEW ZEALAND

Keep it where children cannot Telephone: (09) 579 2792 reach it. A locked cupboard at least one-and- a half metres above the ground is a Date of Information good place to store medicines. 09 July 2019 (Based on datasheet dated 09 July Disposal 2019) If your doctor tells you to stop taking this medicine or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.

Product description

What it looks like TMP 300 mg tablets are white, round tablets marked “TM/300” on one side and “G” on the other side.

Ingredients Active ingredient(s): TMP contains 300 mg of trimethoprim as the active ingredient.

Page 4 of 4