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April 15, 2014 u vol. 111 u no. 15 u 5445–5754 Cover image: Pictured is a section of an ovarian follicle from a woman with polycystic ovarian syndrome (PCOS). Brown immunohistochemical staining reveals the presence of the DENND1A protein in the theca cells of the follicle, where excess androgens are produced in PCOS ovaries. Jan M. McAllister et al. identified increased expression of DENND1A variant proteins in the cytoplasm and nucleus of PCOS theca and granulosa cells. Overexpression of the DENND1A variant 2 (DENND1A.V2) protein in normal theca cells caused a PCOS phenotype of in- creased androgen production, whereas knock-down of DENND1A.V2 in PCOS theca cells decreased androgen synthesis. The authors suggest that the PCOS candidate gene DENND1A might serve as a key regulator of androgen production in the disorder. See the article by McAllisteretal.onpagesE1519–E1527. Image courtesy of Jan M. McAllister. From the Cover E1519 Protein expression in polycystic ovarian syndrome E1510 Oil spill impacts on developing fish hearts 5604 Chemical diversity in Amazonian canopy trees 5610 Thermal limits of ectotherms 5634 Geothermal refuges for life during glacial cycles E1453 Reply to Corbeil et al.: Dedifferentiation Contents and multipotency Tetsuro Kusaba and Benjamin D. Humphreys — THIS WEEK IN PNAS SCIENCE AND CULTURE How science intersects with culture 5445 In This Issue 5447 Supersized viruses Stephen Ornes LETTERS (ONLINE ONLY) COMMENTARIES E1447 Mangrove reemergence in the northernmost range 5448 Vivid watercolor paintbox for eukaryotic algae limit of eastern Florida Katrina T. Forest Chandra P. Giri and Jordan Long See companion article on page 3871 of issue 10 in volume 111 E1449 Reply to Giri and Long: Freeze-mediated expansion 5450 Biologically grounded predictions of species resistance of mangroves does not depend on whether expansion and resilience to climate change is emergence or reemergence Joseph Bernardo Kyle C. Cavanaugh, James R. Kellner, Alexander J. Forde, See companion article on page 5610 Daniel S. Gruner, John D. Parker, Wilfrid Rodriguez, and Ilka C. Feller 5452 Diverse cryptic refuges for life during glaciation Stephen B. Pointing, Barbara Bollard-Breen, E1450 Strong evidence for protein epistasis, weak evidence and Lennard N. Gillman against it See companion article on page 5634 David D. Pollock and Richard A. Goldstein E1451 CD133 might be a pan marker of epithelial cells with dedifferentiation capacity PNAS PLUS Denis Corbeil, Christine A. Fargeas, and József Jászai 5454 Significance Statements Brief statements written by the authors about the significance of Free online through the PNAS open access option. their papers. PNAS u April 15, 2014 u vol. 111 u no. 15 u iii–vii Downloaded by guest on October 1, 2021 5598 Fine-scale ecological and economic assessment of PHYSICAL SCIENCES climate change on olive in the Mediterranean Basin reveals winners and losers CHEMISTRY Luigi Ponti, Andrew Paul Gutierrez, Paolo Michele Ruti, and Alessandro Dell’Aquila 5456 Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes Peyton Shieh, M. Sloan Siegrist, Andrew J. Cullen, PSYCHOLOGICAL AND COGNITIVE SCIENCES and Carolyn R. Bertozzi 5503 Oxytocin promotes group-serving dishonesty 5532 Understanding the mechanism of proteasome 20S core Shaul Shalvi and Carsten K. W. De Dreu particle gating Michael P. Latham, Ashok Sekhar, and Lewis E. Kay BIOLOGICAL SCIENCES COMPUTER SCIENCES E1454 Compound facial expressions of emotion APPLIED BIOLOGICAL SCIENCES Shichuan Du, Yong Tao, and Aleix M. Martinez 5508 Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Mark Juhas, George C. Engelmayr, Jr., Andrew N. 5462 Methanogenic burst in the end-Permian carbon cycle Fontanella, Gregory M. Palmer, and Nenad Bursac Daniel H. Rothman, Gregory P. Fournier, Katherine L. French, Eric J. Alm, Edward A. Boyle, Changqun Cao, and Roger E. Summons BIOCHEMISTRY 5456 Imaging bacterial peptidoglycan with near-infrared 5468 SQUID–SIMS is a useful approach to uncover primary fluorogenic azide probes signals in the Archean sulfur cycle Peyton Shieh, M. Sloan Siegrist, Andrew J. Cullen, Woodward W. Fischer, David A. Fike, Jena E. Johnson, and Carolyn R. Bertozzi Timothy D. Raub, Yunbin Guan, Joseph L. Kirschvink, and John M. Eiler 5514 The docking protein FRS2α is a critical regulator of VEGF receptors signaling 5474 The origin of methanethiol in midocean ridge Pei-Yu Chen, Lingfeng Qin, Zhen W. Zhuang, George hydrothermal fluids Tellides, Irit Lax, Joseph Schlessinger, and Michael Simons Eoghan P. Reeves, Jill M. McDermott, and Jeffrey S. Seewald 5520 Dynamic regulation of FGF23 by Fam20C 5480 Radiocarbon evidence for alternating northern and phosphorylation, GalNAc-T3 glycosylation, southern sources of ventilation of the deep Atlantic and furin proteolysis carbon pool during the last deglaciation Vincent S. Tagliabracci, James L. Engel, Sandra E. Luke C. Skinner, Claire Waelbroeck, Adam E. Scrivner, Wiley, Junyu Xiao, David J. Gonzalez, Hitesh and Stewart J. Fallon Nidumanda Appaiah, Antonius Koller, Victor Nizet, Kenneth E. White, and Jack E. Dixon ENGINEERING 5526 Chronology in lesion tolerance gives priority to 5700 Cellular mechanisms for integral feedback in visually genetic variability guided behavior Karel Naiman, Gaëlle Philippin, Robert P. Fuchs, Bettina Schnell, Peter T. Weir, Eatai Roth, Adrienne L. and Vincent Pagès Fairhall, and Michael H. Dickinson BIOPHYSICS AND COMPUTATIONAL BIOLOGY MATHEMATICS E1463 Molecular mechanism for differential recognition 5485 Higher-order dangers and precisely constructed taxa of membrane phosphatidylserine by the immune in models of randomness regulatory receptor Tim4 Steve Pincus and Burton H. Singer Gregory T. Tietjen, Zhiliang Gong, Chiu-Hao Chen, Ernesto Vargas, James E. Crooks, Kathleen D. Cao, PHYSICS Charles T. R. Heffern, J. Michael Henderson, Mati 5491 Observing (non)linear lattice dynamics in graphite by Meron, Binhua Lin, Benoît Roux, Mark L. Schlossman, ultrafast Kikuchi diffraction Theodore L. Steck, Ka Yee C. Lee, and Erin J. Adams Wenxi Liang, Giovanni M. Vanacore, and Ahmed H. Zewail E1473 From a structural average to the conformational ensemble of a DNA bulge Xuesong Shi, Kyle A. Beauchamp, Pehr B. Harbury, SOCIAL SCIENCES and Daniel Herschlag 5532 Understanding the mechanism of proteasome 20S core ECONOMIC SCIENCES particle gating Michael P. Latham, Ashok Sekhar, and Lewis E. Kay 5497 Preparedness of Americans for the Affordable Care Act Silvia Helena Barcellos, Amelie C. Wuppermann, 5538 A frameshifting stimulatory stem loop destabilizes the Katherine Grace Carman, Sebastian Bauhoff, Daniel L. hybrid state and impedes ribosomal translocation McFadden, Arie Kapteyn, Joachim K. Winter, Hee-Kyung Kim, Fei Liu, Jingyi Fei, Carlos Bustamante, and Dana Goldman Ruben L. Gonzalez, Jr., and Ignacio Tinoco, Jr. iv u www.pnas.org Downloaded by guest on October 1, 2021 5544 Deep classification of a large cryo-EM dataset defines ECOLOGY the conformational landscape of the 26S proteasome 5598 Fine-scale ecological and economic assessment of ł Pia Unverdorben, Florian Beck, Pawe Sledz, Andreas climate change on olive in the Mediterranean Schweitzer, Günter Pfeifer, Jürgen M. Plitzko, Basin reveals winners and losers Wolfgang Baumeister, and Friedrich Förster Luigi Ponti, Andrew Paul Gutierrez, Paolo Michele Ruti, ’ 5550 Crosstalk and the evolution of specificity in and Alessandro Dell Aquila two-component signaling 5604 Amazonian functional diversity from forest canopy Michael A. Rowland and Eric J. Deeds chemical assembly 5556 Solid-state electron transport via cytochrome c depends Gregory P. Asner, Roberta E. Martin, Raul Tupayachi, on electronic coupling to electrodes and across Christopher B. Anderson, Felipe Sinca, Loreli the protein Carranza-Jiménez, and Paola Martinez Nadav Amdursky, Doron Ferber, Carlo Augusto Bortolotti, 5610 Thermal-safety margins and the necessity of Dmitry A. Dolgikh, Rita V. Chertkova, Israel Pecht, thermoregulatory behavior across latitude Mordechai Sheves, and David Cahen and elevation 5562 Dimerization of mammalian kinesin-3 motors results Jennifer M. Sunday, Amanda E. Bates, Michael R. in superprocessive motion Kearney, Robert K. Colwell, Nicholas K. Dulvy, Virupakshi Soppina, Stephen R. Norris, Aslan S. Dizaji, John T. Longino, and Raymond B. Huey Matt Kortus, Sarah Veatch, Michelle Peckham, See Commentary on page 5450 and Kristen J. Verhey 5616 Trait-mediated assembly processes predict successional 5568 Force-dependent isomerization kinetics of a highly changes in community diversity of tropical forests conserved proline switch modulates the Jesse R. Lasky, María Uriarte, Vanessa K. Boukili, mechanosensing region of filamin and Robin L. Chazdon Ž Lorenz Rognoni, Tobias Möst, Gabriel oldák, 5622 Competition–dispersal tradeoff ecologically and Matthias Rief differentiates recently speciated marine bacterioplankton populations CELL BIOLOGY Yutaka Yawata, Otto X. Cordero, Filippo Menolascina, Jan-Hendrik Hehemann, Martin F. Polz, and Roman Stocker E1481 Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition 5628 Deoxygenation of the Baltic Sea during the last century Anan Yu, Yoko Shibata, Bijal Shah, Barbara Calamini, Jacob Carstensen, Jesper H. Andersen, Bo G. Gustafsson, Donald C. Lo, and Richard I. Morimoto and Daniel J. Conley 5574 Sumoylation differentially regulates Sp1 to control cell differentiation ENVIRONMENTAL