Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats
polymers Article Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats Liliana Mititelu-Tartau 1,†, Maria Bogdan 2,* , Daniela Angelica Pricop 3,*, Beatrice Rozalina Buca 1,†, Loredana Hilitanu 1,†, Ana-Maria Pauna 1,†, Lorena Anda Dijmarescu 4,† and Eliza Gratiela Popa 5 1 Department of Pharmacology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; liliana.tartau@umfiasi.ro (L.M.-T.);beatrice-rozalina.buca@umfiasi.ro (B.R.B.); ln.rusu@yahoo.com (L.H.); ana-maria-raluca-d-pauna@umfiasi.ro (A.-M.P.) 2 Department of Pharmacology, Faculty of Pharmacy, University of Medicine and Pharmacy, 200349 Craiova, Romania 3 Department of Physics, Faculty of Physics, “Al. I. Cuza” University, 700506 Iasi, Romania 4 Department of Obstetrics-Gynecology, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania; lorenadijmarescu@yahoo.com 5 Department of Pharmaceutical Technology, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; eliza.popa@umfiasi.ro * Correspondence: bogdanfmaria81@yahoo.com (M.B.); daniela.a.pricop@gmail.com (D.A.P.) † These authors contributed equally to the study. Citation: Mititelu-Tartau, L.; Bogdan, Abstract: The present study reports on the in vivo biocompatibility investigation and evaluation of M.; Pricop, D.A.; Buca, B.R.; Hilitanu, the effects of liposomes containing dexketoprofen in somatic sensitivity in rats. Method: The lipo- L.; Pauna, A.-M.; Dijmarescu, L.A.; somes were prepared by entrapping dexketoprofen in vesicular systems stabilized with chitosan. The Popa, E.G. Biocompatibility and in vivo biocompatibility was evaluated after oral administration in white Wistar rats: Group I (DW): Pharmacological Effects of Innovative distilled water 0.3 mL/100 g body weight; Group II (DEX): dexketoprofen 10 mg/kg body weight Systems for Prolonged Drug Release (kbw); Group III (nano-DEX): liposomes containing dexketoprofen 10 mg/kbw.
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