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The Functional Parasitic Worm Secretome: Mapping the Place of Onchocerca Volvulus Excretory Secretory Products
pathogens Review The Functional Parasitic Worm Secretome: Mapping the Place of Onchocerca volvulus Excretory Secretory Products Luc Vanhamme 1,*, Jacob Souopgui 1 , Stephen Ghogomu 2 and Ferdinand Ngale Njume 1,2 1 Department of Molecular Biology, Institute of Biology and Molecular Medicine, IBMM, Université Libre de Bruxelles, Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium; [email protected] (J.S.); [email protected] (F.N.N.) 2 Molecular and Cell Biology Laboratory, Biotechnology Unit, University of Buea, Buea P.O Box 63, Cameroon; [email protected] * Correspondence: [email protected] Received: 28 October 2020; Accepted: 18 November 2020; Published: 23 November 2020 Abstract: Nematodes constitute a very successful phylum, especially in terms of parasitism. Inside their mammalian hosts, parasitic nematodes mainly dwell in the digestive tract (geohelminths) or in the vascular system (filariae). One of their main characteristics is their long sojourn inside the body where they are accessible to the immune system. Several strategies are used by parasites in order to counteract the immune attacks. One of them is the expression of molecules interfering with the function of the immune system. Excretory-secretory products (ESPs) pertain to this category. This is, however, not their only biological function, as they seem also involved in other mechanisms such as pathogenicity or parasitic cycle (molting, for example). Wewill mainly focus on filariae ESPs with an emphasis on data available regarding Onchocerca volvulus, but we will also refer to a few relevant/illustrative examples related to other worm categories when necessary (geohelminth nematodes, trematodes or cestodes). -
MIM3 Draft Press Release Final Docx
FOR IMMEDIATE RELEASE CONTACT: Tahli Kouperstein, (240) 662-2221 [email protected] EXPECT THE UNEXPECTED IN AN ALL-NEW SEASON OF ANIMAL PLANET’S MONSTERS INSIDE ME -- On October 5, Season Three Shares the Gruesome and Deadly Stories Of Parasites Living Within Us -- (Silver Spring, Md.) – Just because a parasite is not a bear, tiger or some other large predator, that doesn’t mean it can’t be as deadly…if not more so. MONSTERS INSIDE ME returns on Friday, October 5, at 8 PM (ET/PT), retelling the real-life, harrowing dramas of people infected by deadly parasites as doctors and scientists try to unravel each case before it’s too late. MONSTERS INSIDE ME reveals what happens to unsuspecting victims when the smallest creatures turn out to be the biggest monsters. Parasites are organisms that live on or in another species, which then serve as hosts from which the parasite gains nutrients. Failing to recognize or incorrectly diagnosing a parasite can wreak havoc and sometimes cause death. This season, MONSTERS INSIDE ME features stories about people who are harboring tapeworms, flesh-eating diseases, the bubonic plague, rabies, rat-bite fever, a brain-eating amoeba and more. The series also chronicles accounts of victims who suffer from objects that mistakenly are left in them during surgery. • When Kiera, from Springfield, Ohio, experiences severe headaches, she is rushed to the emergency room. Initially, doctors perform a spinal tap and suspect meningitis. After an MRI is performed, doctors realize she might have a teratoma, a tumor that is composed of cells from other organs, which can grow hair, teeth and even eyes. -
A Study of Learning Gains and Attitudes in Biology Using an Emerging Disease Model in Teaching Ecology
A Study of Learning Gains and Attitudes in Biology Using an Emerging Disease Model in Teaching Ecology Susan Chabot CATALySES, Summer 2017 Science Teacher/Department Chair Lemon Bay High School Englewood, Florida [email protected] Abstract Lemon Bay High School (LBHS) is a mid-sized suburban public high school on the southwest coast of Florida in Charlotte County. Although we have a robust honors and advance placement (AP) science program, the number of general students taking additional science classes is small. We have recognized this trend and account dwindling general science enrollment to the shift in biology instruction that followed the state induction of the biology end-of-course exam (EOC). All students must pass biology and take (not pass) the biology EOC to receive a high school diploma. Instruction in preparation for changing biology standards and focus over the last 15 years has drastically altered the delivery of biology content. Although currently more emphasis is placed on project-based/thematic learning units, teachers of biology have been forced to rely on direct instruction methods in order to complete the necessary material for this state-mandated test. The shift has been away from depth of understanding and scientific thinking skills to quick-coverage of material in the hopes students will recall some vocabulary and concepts during the biology end-of-course exam. With stagnant test scores in general biology classes and waning appreciation for the sciences, the belief is that student attitudes and science content understanding will improve through the integration of thematic, project-based learning units that incorporate emerging pathogens, disease, and biology content standards. -
Download Resource Catalog EEG.Pdf
Make the switch to DISPOSABLE EEG ELECTRODES TODAY, because you can’t afford not to! FDA Cleared MR Conditional*/CT Electrodes Artifact Free CT Invisa-Electrodes™ Standard EEG Electrodes Connect with us online to learn more at rhythmlink.com/njc [email protected] 866.633.3754 *patent pending 2 | EEG: PUBLICATIONS 12-month access to all ASET online courses from the time of first logIn. ONLINE COURSES ASET-CEUs awarded for successful completion. EEG courses were developed by recognized subject matter experts (SME) who are outstanding in the field of electroencephalography. University professors were also recruited in the development of these courses. With the ASET EEG national competencies serving as the foundation, SMEs and university professors collaborated on the outline of module topics, and course faculty collaborated on the design, development, and presentation of course offerings. All courses have been peer reviewed for content, content clarity, instructions, and time for completion. EEG 200 - FUNDAMENTALS OF NEUROANATOMY EEG 201 - TESTING PROCEDURES & TERMINOLOGY This course is an introduction to the structures and functions of This course introduces learners to the field of Neurodiagnostic the nervous system. Course content includes basic terms related to Technology by providing descriptions of Neurodiagnostic testing anatomical position, direction, body region, and body plane. The procedures and describing the profession’s Scope of Practice. The bony structures of the skull are presented as well as specific structures Scope of Practice specifies the role of ND technologists as members and functions of the nervous system, such as the brain, brainstem, of the health care team and outlines core responsibilities. -
Lecture 5: Emerging Parasitic Helminths Part 2: Tissue Nematodes
Readings-Nematodes • Ch. 11 (pp. 290, 291-93, 295 [box 11.1], 304 [box 11.2]) • Lecture 5: Emerging Parasitic Ch.14 (p. 375, 367 [table 14.1]) Helminths part 2: Tissue Nematodes Matt Tucker, M.S., MSPH [email protected] HSC4933 Emerging Infectious Diseases HSC4933. Emerging Infectious Diseases 2 Monsters Inside Me Learning Objectives • Toxocariasis, larva migrans (Toxocara canis, dog hookworm): • Understand how visceral larval migrans, cutaneous larval migrans, and ocular larval migrans can occur Background: • Know basic attributes of tissue nematodes and be able to distinguish http://animal.discovery.com/invertebrates/monsters-inside- these nematodes from each other and also from other types of me/toxocariasis-toxocara-roundworm/ nematodes • Understand life cycles of tissue nematodes, noting similarities and Videos: http://animal.discovery.com/videos/monsters-inside- significant difference me-toxocariasis.html • Know infective stages, various hosts involved in a particular cycle • Be familiar with diagnostic criteria, epidemiology, pathogenicity, http://animal.discovery.com/videos/monsters-inside-me- &treatment toxocara-parasite.html • Identify locations in world where certain parasites exist • Note drugs (always available) that are used to treat parasites • Describe factors of tissue nematodes that can make them emerging infectious diseases • Be familiar with Dracunculiasis and status of eradication HSC4933. Emerging Infectious Diseases 3 HSC4933. Emerging Infectious Diseases 4 Lecture 5: On the Menu Problems with other hookworms • Cutaneous larva migrans or Visceral Tissue Nematodes larva migrans • Hookworms of other animals • Cutaneous Larva Migrans frequently fail to penetrate the human dermis (and beyond). • Visceral Larva Migrans – Ancylostoma braziliense (most common- in Gulf Coast and tropics), • Gnathostoma spp. Ancylostoma caninum, Ancylostoma “creeping eruption” ceylanicum, • Trichinella spiralis • They migrate through the epidermis leaving typical tracks • Dracunculus medinensis • Eosinophilic enteritis-emerging problem in Australia HSC4933. -
Introduction: Phylum Nematoda
INTRODUCTION: PHYLUM NEMATODA Outline: I. General morphology and physiology of nematodes. A. Movement by sinusoidal (“S” shaped) undulation requiring elevated pressure of fluid in body cavity or pseudocoelom. 1. Greater than external atmospheric pressure. 2. Keeps worm rigid until muscles (longitudinal) contract to bend it. a. muscles extend from hypodermal lateral cords. b. muscles form dorsal and ventral fields. c. muscles innervated from dorsal and ventral cords. 3. Nerve function essential to life: target of many anthelmintics. B. Feeding requires ingestion at anterior end and forcing nutrient into collapsed intestine. 1. Buccal cavity with or without teeth. 2. Esophagus of various configurations. a. rhabditiform b. strongyliform c. filariform d. stichosome esophagus or trichurid 3. Intestine 4. Anus or cloaca near posterior end. C. Excretion at mid ventral pore near anterior end. 1. Excretory glands 2. Excretory ducts running in lateral cords D. Reproduction - for almost all species of nematodes only sexual replication. 1. Males smaller than females. a. males have prominent to vestigial copulatory bursa - often characteristic of genus. b. male copulatory spicules are cuticular folds of the cloaca used to open the vulva of the female - also characteristic of genus. c. testis, seminal vesicle and vas deferens are one long continuous tube ending at the ejaculatory duct in the cloaca. 2. Females also have a tubular reproductive tract that is usually composed of two branches. a. Ovary, oviduct, uterus and vagina make up a continuous tube that opens to the outside at the vulva on the ventral surface near posterior or anterior ends or at midbody. b. Eggs in the uterus are released to the outside through the vulva. -
Disseminated Strongyloidiasis in an Immunocompromised Host: a Case Report
Asian Pac J Trop Biomed 2017; 7(6): 587–590 587 Contents lists available at ScienceDirect Asian Pacific Journal of Tropical Biomedicine journal homepage: www.elsevier.com/locate/apjtb Case report http://dx.doi.org/10.1016/j.apjtb.2017.05.004 Disseminated strongyloidiasis in an immunocompromised host: A case report Nurul Suhaiza Hassanudin1, Zubaidah Abdul Wahab1, Khalid Ibrahim2, Fadzilah Mohd Nor3,4* 1Microbiology Unit, Department of Pathology, Hospital Sg. Buloh, 47100, Sg. Buloh, Selangor, Malaysia 2Director Office, Hospital Sg. Buloh, 47100, Sg. Buloh, Selangor, Malaysia 3Microbiology Discipline, Faculty of Medicine, Universiti Teknologi MARA, Sg. Buloh Campus, Jalan Hospital, 47000, Sg. Buloh, Selangor, Malaysia 4Integrative Pharmacogenomics Institute (iPROMISE), Level 7, FF3, Universiti Teknologi MARA, Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia ARTICLE INFO ABSTRACT Article history: Infections caused by Strongyloides stercoralis (S. stercoralis) in human are generally Received 28 Oct 2016 asymptomatic, however in immunocompromised individual, hyperinfection may develop Accepted 12 Feb 2017 with dissemination of larvae to extra-intestinal organs. The diagnosis could be easily Available online 25 May 2017 missed due to asymptomatic presentation and insufficient exposure towards the infection itself, which may lead to low index of suspicion as a consequence. In this report, a case of a Malaysian male with underlying diabetes mellitus, hypertension, cerebrovascular ac- Keywords: cident, bullous pemphigus and syndrome of inappropriate antidiuretic hormone secretion Disseminated strongyloidiasis who initially complained of generalized body weakness and poor appetite without any Immunocompromised host history suggestive of sepsis is presented. However, he developed septicemic shock later, Hyperinfection and S. stercoralis larvae was incidentally found in the tracheal aspirate that was sent to Strongyloides stercoralis look for acid fast bacilli. -
Methods in Infectious Disease Epidemiology
1 P A R T Methods in Infectious Disease Epidemiology 1 95337_CH01_001–018.indd 1 2/1/13 11:56 PM 95337_CH01_001–018.indd 2 2/1/13 11:56 PM CHAPTER 1 Early History of Infectious Disease: Epidemiology and Control of Infectious Diseases Kenrad E. Nelson and Carolyn Masters Williams INTRODUCTION wrong theories or knowledge has hindered advances in understanding, one can also cite examples of Epidemics of infectious diseases have been docu- great creativity when scientists have successfully mented throughout history. In ancient Greece and pursued their theories beyond the knowledge of Egypt, accounts describe epidemics of smallpox, the time. leprosy, tuberculosis, meningococcal infections, and diphtheria. 1 The morbidity and mortality of in- fectious diseases profoundly shaped politics, com- THE ERA OF PLAGUES merce, and culture. In epidemics, no one was spared. Smallpox likely disfigured and killed Ramses V in The sheer magnitude and mortality of early epidemics 1157 BCE, although his mummy has a significant are difficult to imagine. Medicine and religion both head wound as well. 2 At times, political upheavals strove to console the sick and dying. However, before exacerbated the spread of disease. The Spartan wars advances in the underlying science of health, medi- caused massive dislocation of Greeks into Athens, cine lacked effective tools, and religious explana tions triggering the epidemic of 430–427 BCE that killed for disease dominated. As early communities con- up to half of the population of ancient Athens. 3 solidated people more closely, severe epidemics of Thucydides’ vivid descriptions of this epidemic make plague, smallpox, and syphilis occurred. -
Wagenmann Named Player of the Weeksports
Wagenmann named TESTER: MIDEAST WILL DEFINE OBAMA’S TENURE Player of the Week SPORTS MONTANA missoulian.com TUESDAY, October 7, 2014 Copyright 2014 $1 FOX CLUB DEATH Inquest to decide if shooting charges are filed By KATHRYN HAAKE Jury to determine whether use of force was justified in fatal incident ON MISSOULIAN.COM of the Missoulian ■ More coverage: A coroner’s inquest will killed in a Missoula strip club’s County Attorney Jason Marks who admitted fatally shooting Read more about the determine if charges are filed in parking lot early on the morning said the outcome of the inquest Hymel in the chest outside the Fox Club shooting the shooting death of of Sept. 1. will determine whether Fox Club Cabaret. online with this story. Christopher Hymel, the 23- In a decision announced prosecutors pursue charges year-old Louisiana man who was Monday, Deputy Missoula against Michael Gordon, the man See SHOOTING, Page A8 POTOMAC Residents HONORING SERVICE lose their 3 veterans from WWII, Vietnam, Afghanistan awarded Purple Heart cellphone coverage Sprint buys tower but doesn’t offer service in Montana; some caught off-guard By KIM BRIGGEMAN of the Missoulian POTOMAC – This valley doesn’t have cellphone service any more. The tower that stands against the pines on the southern fringe was switched off last Thursday, Oct. 1, one of the victims of the long-planned Sprint takeover of Cellular One. Some knew it was coming. Gary and Becky Douglas Delp say they didn’t. They’ve used AT&T phones for the past several years at their business, Heritage Timber, and the roaming service worked so See CELLPHONE, Page A8 SOUTH SUDAN MICHAEL GALLACHER/Missoulian U.S. -
The Biology of Strongyloides Spp.* Mark E
The biology of Strongyloides spp.* Mark E. Viney1§ and James B. Lok2 1School of Biological Sciences, University of Bristol, Bristol, BS8 1TQ, UK 2Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6008, USA Table of Contents 1. Strongyloides is a genus of parasitic nematodes ............................................................................. 1 2. Strongyloides infection of humans ............................................................................................... 2 3. Strongyloides in the wild ...........................................................................................................2 4. Phylogeny, morphology and taxonomy ........................................................................................ 4 5. The life-cycle ..........................................................................................................................6 6. Sex determination and genetics of the life-cycle ............................................................................. 8 7. Controlling the life-cycle ........................................................................................................... 9 8. Maintaining the life-cycle ........................................................................................................ 10 9. The parasitic phase of the life-cycle ........................................................................................... 10 10. Life-cycle plasticity ............................................................................................................. -
Residents Day Virtual Meeting Henry Ford Health System
May 7, 2021 Residents Day Virtual Meeting Hosted by: Henry Ford Health System - Detroit Internal Medicine Residency Program Medical Student Day Virtual Meeting Sponsored by: & Residents Day & Medical Student Day Virtual Program May 7, 2021 MORNING SESSIONS 6:45 – 7:30 AM Resident Program Directors Meeting – Sandor Shoichet, MD, FACP Via Zoom 7:30 – 9:30 AM Oral Abstract Presentations Session One Abstracts 1-10 9:00 – 10:30 AM Oral Abstract Presentations Session Two Abstracts 11-20 10:30 AM – 12:00 PM Oral Abstract Presentations Session Three Abstracts 21-30 KEYNOTE SESSON COVID Perspectives: 1. “ID Perspective: Inpatient Work and Lessons from Infection Control Point of View” – Payal Patel, MD, MPH 12:00 – 1:00 PM 2. “PCCM Perspective: Adding Specific Lessons from ICU Care/Burden and Possible Response to Future Pandemics” – Jack Buckley, MD 3. “Pop Health/Insurance Perspective – Population Health/Social Net of Health/Urban Under-Represented Care During COVID” – Peter Watson, MD, MMM, FACP AFTERNOON SESSIONS RESIDENTS PROGRAM MEDICAL STUDENT PROGRAM Residents Doctor’s Dilemma™ 1:15 – 2:00 PM Nicole Marijanovich MD, FACP 1:00 – 1:30 pm COVID Overview – Andrew Jameson, MD, FACP Session 1 Residents Doctor’s Dilemma™ 2:00 – 2:45 PM 1:30 – 2:15 am COVID – A Medical Students Perspective Session 2 Residents Doctor’s Dilemma™ 4th Year Medical Student Panel: Post-Match Review 2:45 – 3:30 PM 2:15 – 3:00 pm Session 3 of Interviews Impacted by COVID Residents Doctor’s Dilemma™ Residency Program Director Panel: A Residency 3:30 – 4:15 PM 3:00 – 3:45 -
Parasites 1: Trematodes and Cestodes
Learning Objectives • Be familiar with general prevalence of nematodes and life stages • Know most important soil-borne transmitted nematodes • Know basic attributes of intestinal nematodes and be able to distinguish these nematodes from each other and also from other Lecture 4: Emerging Parasitic types of nematodes • Understand life cycles of nematodes, noting similarities and significant differences Helminths part 2: Intestinal • Know infective stages, various hosts involved in a particular cycle • Be familiar with diagnostic criteria, epidemiology, pathogenicity, Nematodes &treatment • Identify locations in world where certain parasites exist Presented by Matt Tucker, M.S, MSPH • Note common drugs that are used to treat parasites • Describe factors of intestinal nematodes that can make them emerging [email protected] infectious diseases HSC4933 Emerging Infectious Diseases HSC4933. Emerging Infectious Diseases 2 Readings-Nematodes Monsters Inside Me • Ch. 11 (pp. 288-289, 289-90, 295 • Just for fun: • Baylisascariasis (Baylisascaris procyonis, raccoon zoonosis): Background: http://animal.discovery.com/invertebrates/monsters-inside-me/baylisascaris- [box 11.1], 298-99, 299-301, 304 raccoon-roundworm/ Video: http://animal.discovery.com/videos/monsters-inside-me-the-baylisascaris- [box 11.2]) parasite.html Strongyloidiasis (Strongyloides stercoralis, the threadworm): Background: http://animal.discovery.com/invertebrates/monsters-inside-me/strongyloides- • Ch. 14 (p. 365, 367 [table 14.1]) stercoralis-threadworm/ Videos: http://animal.discovery.com/videos/monsters-inside-me-the-threadworm.html http://animal.discovery.com/videos/monsters-inside-me-strongyloides-threadworm.html Angiostrongyliasis (Angiostrongylus cantonensis, the rat lungworm): Background: http://animal.discovery.com/invertebrates/monsters-inside- me/angiostrongyliasis-rat-lungworm/ Video: http://animal.discovery.com/videos/monsters-inside-me-the-rat-lungworm.html HSC4933.