Anti-CLDN4 polyclonal antibody (CABT-B1777) This product is for research use only and is not intended for diagnostic use.
PRODUCT INFORMATION
Immunogen Claudin-4 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Claudin-4.
Isotype IgG
Source/Host Rabbit
Species Reactivity Human
Purification Antigen Affinity Purified
Conjugate Unconjugated
Applications WB, ICC
Epitope Near C-terminus
Molecular Weight ~58 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Format Liquid
Concentration Please refer to lot specific datasheet.
Size 100 μg
Buffer PBS (pH 7.2) with 0.02% sodium azide.
Preservative 0.02% Sodium Azide
Storage Stable for 1 year at 2-8°C from date of receipt.
BACKGROUND
Introduction Claudin 4, also known as Clostridium perfringens enterotoxin receptor, or CPE-R, or CPE- receptor or Williams-Beuren syndrome chromosomal region 8 protein, and encoded by the gene CLDN4/CPER/CPETR1/WBSCR8, plays a critical role in tight junction specific obliteration of intercellular space. Claudin 4 directly interacts with several important tight junction associated proteins including ZO-1,2,3 and EPHA2 proteins, and through these interactions, Claudin 4 regulates tight junction formation. Claudin 4 is localized to cell junctions and membranes at tight
45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]
Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved junctions. Claudin 4 is expressed in most tissues particularly in intestine, liver, and pancreas. Defects in Claudin 4 may be associated with Williams Beuren syndrome genetic deletion syndrome. Claudin 4 is also over expressed in many cancers and thus is a target of anti-cancer research using C. perfringens enterotoxin.
GENE INFORMATION
Entrez Gene ID 1364
UniProt ID O14493
45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]
Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved