Anti-CLDN4 polyclonal antibody (CABT-B1777) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Immunogen Claudin-4 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Claudin-4.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Antigen Affinity Purified

Conjugate Unconjugated

Applications WB, ICC

Epitope Near C-terminus

Molecular Weight ~58 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Format Liquid

Concentration Please refer to lot specific datasheet.

Size 100 μg

Buffer PBS (pH 7.2) with 0.02% sodium azide.

Preservative 0.02% Sodium Azide

Storage Stable for 1 year at 2-8°C from date of receipt.

BACKGROUND

Introduction Claudin 4, also known as Clostridium perfringens enterotoxin receptor, or CPE-R, or CPE- receptor or Williams-Beuren syndrome chromosomal region 8 , and encoded by the CLDN4/CPER/CPETR1/WBSCR8, plays a critical role in tight junction specific obliteration of intercellular space. Claudin 4 directly interacts with several important tight junction associated including ZO-1,2,3 and EPHA2 proteins, and through these interactions, Claudin 4 regulates tight junction formation. Claudin 4 is localized to cell junctions and membranes at tight

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved junctions. Claudin 4 is expressed in most tissues particularly in intestine, liver, and pancreas. Defects in Claudin 4 may be associated with Williams Beuren syndrome genetic deletion syndrome. Claudin 4 is also over expressed in many cancers and thus is a target of anti-cancer research using C. perfringens enterotoxin.

GENE INFORMATION

Entrez Gene ID 1364

UniProt ID O14493

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved