X-Ray Detectors for Medical, Industrial and Security Applications 2019

From Technologies to Markets

Marjorie Villien, PhD As a Technology & Market Analyst, Marjorie Villien, PhD is member of the Medical Technologies business unit at Yole Développement (Yole). She is a daily contributor to the development of these activities with a dedicated collection of market & technology reports as well as custom consulting projects. After spending two years at Harvard and prior Yole, Marjorie served as a research scientist at INSERM. Marjorie Villien graduated from Grenoble INP and holds a PhD in physics & medical imaging. Email: [email protected]

Jérôme Mouly

Jerôme Mouly serves as a Senior Technology & Market Analyst & Business Developer specialized in microtechnologies for inkjet & bioMEMS sensors. Since 2000, he has participated in more than 100 marketing and technological analyses for industrial groups, start-ups and institutes. Previously, Jerome was involved in a support action for value creation of smart miniaturized systems research projects at Yole Finance Innovation, part of Yole Développement. Jérôme holds a Master of Physics from the University of Lyon (France).

Email: [email protected]

 Executive Summary 13 o Major players and market shares at the system level

 Context 51  Supply chain, market shares and value chain 135 o Context o Mergers and acquisitions o Scope of the report o Supply chain analysis o Historical perspective and synergies with other markets o Who works with who? per OEM o Technology landscape o Detectors manufacturers market shares by technologies o Focus on the Chinese ecosystem  Market forecasts 73 o Focus on component divisions from system manufacturers o X-ray detectors market and forecasts 2018-2024 (value and units) at o Value chain analysis the system level by applications o X-ray detectors market and forecasts 2018-2024 (value and units) at  Technology trends 158 the detector level by applications o Technology landscape o X-ray detectors market and forecasts 2018-2024 (value and units) at o Technology evolutions the detector level by technologies o Technologies roadmap o Technologies penetration per segments o Manufacturing process o Cost analysis o Commercial products available and future product launch o New technology trends  Market trends by segments 86 o For each segment: Medical (subdivised in mammography, surgery and  Conclusions 192 interventional, CT, dental),Veterinary, Industrial and Security o Market drivers o Technical requirements o Detectors market per technology 2018-2024 (value and units)

200+ slides of market and technology analysis

Acteon, Adani systems, Agfa, AIV-BEX, Ajat, AMS, Analogic, Anke, Asahi, Astrophysics, AUO, Autoclear, BASF, BOE, Caeleste, Canon, Careray, Carestream, cefla, China electronics panda crystal technology, Chunghwa picture tubes, Comet Group, CSOT, Cuattro, CyXplus, Dabi Atlante, Dectris, Detection Technology, Direct Conversion, Dpix, Drtech, Dürr, Ecoray, EIA, Excelitas, Fiscan, Fujifilm, GE, GE healthcare, Gendex, Gilardoni, Gongbu HiTek, Hamamatsu, Heska, Hitachi, Hologic, Idetec, Idexx laboratories, iM3, ImageWorks, Imec, Innolux, Innomed, InterMedical, Iray, Isdi, Isorg, Italray, Joled, Kapri Corp, KavoKerr, Konica Minolta, L3 security and detection systems, Led dental, Leidos, LG, Lixi, Mars bioimaging, Medical Econet, Mediso, Minfound, MinX-ray, Mistras, Morita, MultiX, Myvet Imaging, Neusoft, Nikon, Nordson Dage, North Star Imaging, NT3, Nuctech, ON Semiconductor, OSI systems, PaloDex, Panasonic, Philips, Planmeca, Prexion, Rapiscan, Rayence, Rgenoray, Rigaku, Ritter, Safeway system, Samsung, Scanna, Sedecal, Sharp, Shimadzu, Siemens healthineers, SinoVision, Sirona, Smiths Detection, Sony, Soredex, Sound, Stephanix, Teledyne Dalsa, Thales, TNO, Todd Research, Toshiba, Towerjazz, Trixell, Unicomp, Uniqscan, United Imaging, Vanderlande, Varex, Vatech, Vetel diagnostics, VGI, Vidisco, Vieworks, Vision Systems, VJ Technologies, Westminster Inetrnational, Xfab, X-scan imaging, Zeiss, Ziehm, 3DX-ray

And many more !

Information gathered through direct discussions with players all along the supply chain

• Provide an overview of X-ray imaging markets and technological landscapes at the system and detector levels, as well as an understanding of established and upcoming players, their technologies and their advantages/drawbacks, and how these will evolve in coming years.

• Provide market data and forecasts, along with market share at the system and detector levels by applications, including medical, veterinary, industrial and security, and technologies, including aSi, aSe, CCD, CMOS, photodiodes and IGZO, in dollar value and in unit volumes.

• Identify where the opportunities lie for the different players along the supply chain, from materials suppliers and foundries, to detectors manufacturers and system developers.

• Discuss the different technologies used today, such as aSi, aSe, CCD, CMOS, photodiodes, but also the alternatives coming to the market in the next few years, including IGZO and single photon counting and possible new technologies being tested in R&D, such as perovskites, organic materials and curved sensors.

 Stationary X-Ray systems  Radiography  Mobile X-Ray systems  Mammography  Equine equipment  Fluoroscopy  Etc.  Dental X-ray  CT scan  Etc.

We are Medical following the Veterinary medical imaging market for years and we are now also following the veterinary, Industrial Non industrial and Destructive Security security Testing (NDT) markets

 Automotive,  Airport check  Oil and gas  Cargo security systems  Energy  Aerospace  Pharmaceutical industry  Etc.  Food industry  Recycling and waste sorting  Etc.

Soon after the X-ray’s 1895 invention there was a rapid X-ray systems arrived to the agreement that it could be used security business later on, in the for medical applications. 90’s and especially in airports to X-ray screen people and baggage. imaging However, it was only in the early arrived first 20’s that X-ray images became in the medical field seen as part of routine patient but then care. spread to the Security industrial and went for the security recently due Industrial to security threats X rays were use early on to probe Medical the structure of crystals and atoms, and is has been used rapidly for industrial quality controls.

Commercially available: • CCD, aSi, aSe, CMOS

Commercial maturity of the main Soon to be commercially available: technologies being used in X-ray • IGZO, single photon counting imaging detectors

R&D: • Organic materials, curved sensors, perovskites

The data is expressed as follows: o In volume (units) System o In market value ($M)

Equipment Market data and forecasts covered in this report The following sections ex: 3D CBCT x-ray, CT scanner, airport X-ray system present market data and forecast Detector Detector = sensor + scintillator (if needed) + ASIC with the following terminology ex: aSi flat panel detector, CMOS Intraoral detector, CT scanner detector

Degree integration of Degree Sensor Sensor = first level packaging

ex: CMOS sensor, photodiodes

Component ©2019 | X-Ray Detectors for Medical, Industrial and Security Applications | www.yole.fr | SAMPLE 9 X-RAY MARKET DATA AND FORECATS Market data and forecast – X-ray detector level – By applications

The growth of the X-ray market is more striking when looking at the detector level with a CAGR2018-2024 of 5.9%. • The impressive growth of the security and industrial X-ray detector market can be explained by changes in technology (switch toward CT-scan in the security segment) or by an increased attractivity of this method in industrial NDT. • The medical X-ray market is a mature market, but new technologies are coming that could change the landscape in the next few years.

2024

33% 5% 15% 9% 8% 3% 11% 17%

$2.8B

2018

37% 6% 15% 10% 8% 2% 9% 13%

$2.0B

Static Mammography Surgery and interventional CT-scan Dental Veterinary Industrial Security

2024 $18M $62M -1% 2018 -19% $2.8B $67M $66M $2B $829M $510M +9% +13% $245M $501M

CAGR2018-2024 $236M $1,118M +5.9% +64%* +0.5% $1,085M

Legend: CCD aSe CMOS Photodiodes array aSi IGZO*

* IGZO market segment will start only in 2020 ©2019 | X-Ray Detectors for Medical, Industrial and Security Applications | www.yole.fr | SAMPLE 12 X-RAY IMAGING ECOSYSTEM: 2016 – 2019 MAJOR ACQUISITIONS*

* Non exhaustive list of acquisitions

Legend: acquired Medical market Security market acquired Detector players 2019 acquired 2018 2017 2016 acquired acquired

acquired

acquired acquired As new challengers are coming to the market, especially from China/Asia, historical players are expanding their portfolio through M&A… ©2019 | X-Ray Detectors for Medical, Industrial and Security Applications | www.yole.fr | SAMPLE 13 X-RAY TECHNOLOGY, COMMERCIAL ROADMAP

CMOS flat panels Photon Counting • Lower dose • Spectral imaging • Higher speed and resolution • High image quality

aSe IGZO Performance • Direct conversion • Better cost efficiency • Lower noise aSi flat panels • Lower cost • Higher integration CCD – Image intensifier • Improved quality • Digitalization

Time

o Context o Historical perspective o Synergies with other markets o Technology landscape

o X-ray detectors market and forecasts 2018-2024 (value and units) o at the system level by applications o at the detector level by applications o at the detector level by technologies o Technologies penetration per segments o Cost analysis

o For each segment: Medical (subdivided in mammography, surgery and interventional, CT, dental), Veterinary, Industrial and Security o Market drivers and technical requirements o Detectors market per technology 2018-2024 (value and units) o Market shares at the system level

o Mergers and acquisitions o Supply chain and value chain analysis o Who works with who? per OEM o Detectors manufacturers market shares by technologies o Focus on the Chinese ecosystem o Focus on component divisions from system manufacturers

o Technology landscape and evolutions o Technologies roadmap o Manufacturing process o Commercial products available and future product launch o New technology trends

©2019 | X-Ray Detectors for Medical, Industrial and Security Applications | www.yole.fr | SAMPLE 20 X-RAY DETECTORS FOR MEDICAL, INDUSTRIAL AND SECURITY APPLICATIONS 2019 Market & Technology Report - May 2019 New technologies are finally arriving in the X-ray market and reshuffling the pack of players. THE X-RAY DETECTOR MARKET REACHED $2B IN 2018 DRIVEN WHAT’S NEW BY THE MEDICAL SEGMENT, ACCOUNTING FOR 75% OF THE MARKET, • The previous report about X-ray imaging also included other medical BUT THE INDUSTRIAL AND SECURITY MARKET ARE GAINING SHARES imaging technologies like PET, X-ray imaging’s first application was in the medical array detectors, which were worth $500M. Yole endoscopy, OCT, and ultrasound. area, with the first radiography being done in 1895 Développement is expecting Indium Gallium Zinc We have now decided to analyze by Wilhelm Röntgen. The discovery of X-rays Oxide (IGZO) flat panels to make a big entry into the each modality more deeply led to a revolution in medical imaging. Today market as soon as 2021 and to reach $236M in 2024. • We also enlarge the scope of the technology is gaining traction in the fields of IGZO is directly competing with aSi and CMOS, the report adding the veterinary, veterinary care, industrial non-destructive testing but CMOS is still the reference technology for industrial and security markets (NDT) and security. applications needing high resolution. However, • This report focuses on X-ray The X-ray market was worth $19B in 2018 at the the price erosion is slow with CMOS because the imaging at the system and detector system level. The medical market is by far the number of systems sold is still low in the X-ray level biggest, with $16B revenues in 2018. field and the size of the flat panels is large. The only REPORT KEY FEATURES At the detector level, the X-ray market was worth reason for price erosion is the competition with • Historical perspective and synergies $2.0B in 2018 and is expected to grow with a aSi. That explains why the price difference between with other markets Compound Annual Growth Rate from 2018-2024 CMOS and aSi is decreasing, especially for smaller • Market data and forecasts at the panels. (CAGR2018-2024) of 5.9% to reach $2.8B in 2024. system and detector level by Today, X-ray imaging is almost exclusively based This report summarizes market data and forecasts applications including medical, on solid-state sensors. Flat panel detectors using for the period 2018-2024, breaking the system veterinary, industrial and security amorphous silicon (aSi) and CMOS represent the market into segments and dividing the detector and technologies like aSi, aSe, CCD, biggest share of the market, being worth $1.3B in market by application and technology. It also covers CMOS, photodiodes and IGZO, 2018. They were followed by silicon photodiode market drivers and cost analyses. in dollar value and in unit volumes. The medical market is subdivided 2018 – 2024 X-ray detector market breakdown by market segment into static, mammography, surgery 2018 and interventional, CT and dental • Technology penetration and 37% 6% 15% 10% 8% 2% 9% 13% market trends by segment, including medical, covering static, mammography, surgery and $2.0B interventional, CT and dental, as well as veterinary, industrial and 2024 security • Supply chain analysis with market 33% 5% 15% 9% 8% 3% 11% 17% shares at the system level by segment and at the detector level by technology $2.8B • Technology landscape, evolution Static Mammography Surgery and interventional CT-scan Dental Veterinary Industrial Security and roadmaps (Yole Développement, May 2019)

IGZO AND PHOTON COUNTING TECHNOLOGIES ARE READY TO FINALLY REACH COMMERCIALIZATION, HELPED BY ECONOMIC AND TECHNICAL DRIVERS

Commercialization of IGZO flat panels for X-ray this new technology because it offers better image imaging begun last year with Rayence, iRay and quality at an affordable cost. However, ramp-up Varex presenting IGZO based products. Yole will depend on how rapidly the technology is Développement is expecting a rapid ramp-up of IGZO integrated into new products. integration in new products as the technology is Another very interesting development is single ready and the supply chain is almost ready too. photon counting for spectral imaging. With the Imaging system manufacturers are eager to use acquisition of MultiX by Detection Technology X-RAY DETECTORS FOR MEDICAL, INDUSTRIAL AND SECURITY APPLICATIONS 2019

and with Varex buying Direct Conversion AB, photon interest in single photon counting and spectral imaging counting is no longer just a promising technology. It is focused on discrimination of materials in security will soon be available in products from the biggest and industrial applications and use of targeted contrast detector manufacturers. System manufacturers’ agents in medical applications. We are also seeing a growing trend towards 2018 – 2024 X-ray detector market revenue by technology 3D imaging that translates into more computed tomography (CT) being sold into various medical, security and industrial applications. 2024 18M 62M X-ray line scan cameras are mainly used in industrial -19% -1% 2.8B 2018 and security applications. The next trend in this field

6M 2B is the use of time delay integration (TDI) cameras 66M 829M to enhance image quality. We are already seeing TDI 10M +9% +13% cameras in food sorting and non-destructive testing 24M 01M of microelectronics.

26M 1,118M Artificial intelligence (AI) will be the next megatrend CAR 2018-2024 +64%* +0.5% to follow in the field of imaging. This is especially true .9 1,08M in X-ray, as 3D and multi-spectral imaging requires processing of massive amounts of data. CCD aSe CMOS Photodiodes array aSi IGZO* This report describes the technology landscape * IO maret segment will start only in 2020 and evolution and lays out the roadmaps Yole Développement expects that progress might follow. (Yole Développement, May 2019)

NEW TECHNOLOGIES REACHING COMMERCIALIZATION ARE RESHUFFLING THE CARDS OF MANY PLAYERS IN THE SUPPLY CHAIN

The X-ray detector market is now like the electronics At the system level, the medical and dental segments market. It’s becoming difficult to develop all the are dominated by few major players, like Siemens, components internally. A company needs a supply Philips, GE and Canon. Smaller players with niche chain with partners that are expert in their domains: products are also gaining market share in areas like detector companies, software companies that have AI mammography, dental or surgery. Chinese players specialists, etc. such as United Imaging are also gaining market share, After a consolidation of the supply chain in the medical even in the high-end markets. The X-ray security business (Canon acquired Toshiba Medical), the security market is very consolidated, with a few key players business (Smiths Detection acquired Safran Morpho, accounting for around 60% of the overall market OSI Systems acquired Rapiscan) and the detector share in 2018. The key players include OSI Systems, manufacturers (Teledyne Dalsa acquired e2v, Varex Smiths Detection, L3 and Analogic Corporation, but acquired Perkin Elmer) in 2016-2017, we now see the also Chinese players such as Safeway System and detector makers expanding their product portfolio to Nuctech. The industrial segment is divided up into add photon counting (Varex, Detection Technology). a lot of applications with very different needs and specifications. This explains the large number of small X-ray imaging ecosystem: 2016 – 2019 major acquisitions* companies in this segment compared to the medical segment where the main products are in the hands of * on ehaustive list of acuisitions 4-5 main players. Legend: acquired Medical market In the flat panel market , big companies such as Teledyne Security market Dalsa, Varex and Trixell are still the main players. Detector players acquired 2019 However, Asian manufacturers such as Vieworks, acquired 2018 Rayence, iRay and CareRay are gaining market shares 2017 and are at the forefront of new technologies. The main applications of photodiode array detectors 2016 acquired acquired in X-ray imaging are line scan imaging, mainly for industrial applications but also and CT-scan, in medical, acquired industrial and security applications. The main players acquired are Hamamatsu, ams and Detection Technology. acquired As new challengers are coming to the market, especially from China/Asia, historical players are expanding their portfolio through MA… This report includes a complete supply chain analysis and describes market shares by segment at the system level, and by technology at the detector level. (Yole Développement, May 2019) MARKET & TECHNOLOGY REPORT

REPORT OBJECTIVES • Provide an overview of X-ray imaging markets and technological landscapes at the system and detector levels, as well as an understanding of established and upcoming players, their technologies and their advantages/drawbacks, and how these will evolve in coming years. • Provide market data and forecasts, along with market share at the system and detector levels by applications, including medical, veterinary, industrial and security, and technologies, including aSi, AUTHORS aSe, CCD, CMOS, photodiodes and IGZO, in dollar value and in unit volumes. As a Technology & Market Analyst, Medical • Identify where the opportunities lie for the different players along the supply chain, from materials Imaging & Biophotonics, Marjorie Villien, suppliers and foundries, to detectors manufacturers and system developers. PhD is member of the Life Sciences & • Discuss the different technologies used today, such as aSi, aSe, CCD, CMOS, photodiodes, but Healthcare division at Yole Développement. also the alternatives coming to the market in the next few years, including IGZO and single photon counting and possible new technologies being tested in R&D, such as perovskites, organic She is a daily contributor to the development materials and curved sensors. of medical technologies activities with a dedicated collection of market & technology COMPANIES CITED IN THE REPORT (non exhaustive list) reports as well as custom consulting projects. Acteon, Adani systems, Agfa, AIV-BEX, Ajat, AMS, Analogic, Anke, Asahi, Astrophysics, AUO, Autoclear, As an example, Marjorie was involved in a BASF, BOE, Caeleste, Canon, Careray, Carestream, cefla, China electronics panda crystal technology, project focused on videoscopy for endoscopy Chunghwa picture tubes, Comet Group, CSOT, Cuattro, CyXplus, Dabi Atlante, Dectris, Detection application, to understand the benefits of the Te chnolog y, Dire c t Conver sion , D pix , Dr te ch , Dürr, Ecor ay, E I A , E xce lit a s , Fisc an , Fujifilm , G E , G E he alt hc are , CCD/CMOS solution and identify business Gendex, Gilardoni, Gongbu HiTek, Hamamatsu, Heska, Hitachi, Hologic, Idetec, Idexx laboratories, iM3, opportunities. In parallel, she performed an ImageWorks, Imec, Innolux, Innomed, InterMedical, Iray, Isdi, Isorg, Italray, Joled, Kapri Corp, KavoKerr, analysis of the PET detectors technology to Konica Minolta, L3 security and detection systems, Led dental, Leidos, LG, Lixi, Mars bioimaging, Medical evaluate the impact of innovative Solid-State Econet, Mediso, Minfound, MinX-ray, Mistras, Morita, MultiX, Myvet Imaging, Neusoft, Nikon, Nordson technologies on the evolution of the nuclear Dage, North Star Imaging, NT3, Nuctech, ON Semiconductor, OSI systems, PaloDex, Panasonic, Philips, medicine industry. After spending two years Planmeca, Prexion, Rapiscan, Rayence, Rgenoray, Rigaku, Ritter, Safeway system, Samsung, Scanna, Sedecal, at Harvard, Marjorie served as a research Sharp, Shimadzu, Siemens healthineers, SinoVision, Sirona, Smiths Detection, Sony, Soredex, Sound, scientist at INSERM in the field of medical Stephanix, Teledyne Dalsa, Thales, TNO, Todd Research, Toshiba, Towerjazz, Trixell, Unicomp, Uniqscan, imaging for the treatment of Alzheimer’s United Imaging, Vanderlande, Varex, Vatech, Vetel diagnostics, VGI, Vidisco, Vieworks, Vision Systems, VJ disease, stroke and cancers. She has spoken Technologies, Westminster Inetrnational, Xfab, X-scan imaging, Zeiss, Ziehm, 3DX-ray and many more! in numerous international conferences and TABLE OF CONTENTS (complete content on i-Micronews.com) has authored or co-authored 11 papers and Executive summary 13 - Technical requirements 1 patent. Marjorie is daily exchanging with Context 51 - Detector market per technology 2018- clinicians, researchers and industrial partners 2024 (value and units) to understand technology issues and > Context - Major players and market share at the ensure the connection between R&D and > Scope of the report system level applications. Marjorie Villien graduated from > Historical perspective and synergies with - Supply chain, market share and value chain Grenoble INP and holds a PhD in physics & other markets > Mergers and acquisitions medical imaging. > Technology landscape > Supply chain analysis Market forecasts 73 > Which OEM works with who? > X-ray detector market and forecasts 2018- > Detectors manufacturers market shares by 2024 (value and units) at the system level technologies by application > Focus on the Chinese ecosystem > X-ray detector market and forecasts 2018- > Focus on system manufacturers’ 2024 (value and units) at the detector level component divisions by application > Value chain analysis > X-ray detectors market and forecasts Technology trends 158 Jérôme Mouly serves as a Senior 2018-2024 (value and units) at the detector Technology & Market Analyst & Business level by technology > Technology landscape Developer specialized in microtechnologies > Technology penetration by segments > Technology evolutions > Cost analysis > Technologies roadmap for inkjet & bioMEMS sensors at Yole Développement (Yole). Jérôme is supporting Market trends by segment 86 > Manufacturing process > Commercial products available and future the development of strategic projects, > For each segment: medical, subdivided into product launch following leading customers of the company, mammography, surgery and interventional, > New technology trends within the Life Sciences & Healthcare CT, dental; Veterinary; Industrial; and Conclusions 192 division. Since 2000, he is also engaged in Security more than 100 marketing and technological - Market drivers Yole Développement presentation 195 analyses for industrial groups, start-ups and institutes related to semiconductor & RELATED REPORTS medical technologies industry, in the field of B enef it from our B undle & Annual Subscription offers and access our analyses at the best available inkjet functional printing, wearable sensors price and with great advantages and connected medical devices. Jérôme • Machine Vision for Industry and is also regularly involved in international Automation 2018 conferences, giving presentations and delivering keynotes. Jérôme Mouly holds • Status of the CMOS Image Sensor Industry 2018 a Master of Physics from the University of Lyon (France). • Ultrasound Sensing Technologies for Medical, Industrial and Consumer Applications 2018

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Industrial Medical We work and defense systems across multiples industries to understand Energy the impact of management Automotive More-than- Moore technologies from device Mobile phone to system Transportation and makers consumer electronics From A to Z…

©2019About Yole| www.yole.fr Développement | About | Yolewww.yole.fr Développement | ©2019 28 REPORTS COLLECTION o Over the course of more than 20 years, Yole Développement has grown to become a group of companies. Together with System Plus Consulting and KnowMade, we now provide marketing, technology and strategy consulting, media and corporate finance services, reverse costing, structure, process and cost analysis services and well as intellectual property (IP) and patent analysis. Together, our group of companies is collaborating ever closer and therefore will offer, in 2019, a collection of over 125 reports, 10 new monitors and 120 teardowns. Combining respective expertise and methodologies from the three companies, they cover:

• MEMS & Sensors • Power electronics • RF devices & technologies • Compound semiconductors • Medical technologies • Solid state lighting • Semiconductor Manufacturing • Displays • Advanced packaging • Software • Memory • Imaging • Batteries and energy management • Photonics o If you are looking for: • An analysis of your product market and technology • A review of how your competitors are evolving • An understanding of your manufacturing and production costs • An understanding of your industry’s technology roadmap and related IPs • A clear view supply chain evolution Our reports and monitors are for you! www.i-Micronews.com o Our team of over 70 analysts, including PhD and MBA qualified industry veterans from Yole Développement, System Plus Consulting and KnowMade, collect information, identify trends, challenges, emerging markets, and competitive environments. They turn that information into results and give you a complete picture of your industry’s landscape. In the past 20 years, we have worked on more than 2,000 projects, interacting with technology professionals and high-level opinion makers from the main players of their industries and realized more than 5,000 interviews per year. WHAT TO EXPECT IN 2019? In 2019 we will extend our offering with a new ‘monitor’ product which provides more updates on your industry during the year. The Yole Group of Companies is also building on and expanding its investigations of the memory industry. Moreover, in parallel, the Yole Group reaffirms its commitment to a new collection of reports mixing software and hardware and is increasing its involvement in displays, radio-frequency (RF) technology, advanced substrates, batteries and compound semiconductors. Last but not least, System Plus Consulting is developing its teardowns service providing 120+ offers related to phones, smart home, wearables and connected devices. Discover our 2019 program right now, and ensure you get a true vision of the industry. Stay tuned!

18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

Market –Technology – Strategy – by Yole Développement Yole Développement (Yole) offers market reports including quantitative market forecasts, technology trends, company strategy evaluation and indepth application analyses. Yole will The markets targeted are : publish more than 55 reports in 2019, with our partner PISEO contributing to some of the lighting reports. • Mobile & Consumer

Reverse Costing® – Structure, Process and Cost Analysis – by • Automotive & Transportation System Plus Consulting The Reverse Costing® report developed by System Plus Consulting provides full • Medical teardowns, including detailed photos, precise measurements, material analyses, manufacturing process flows, supply chain evaluations, manufacturing cost analyses and • Industrial selling price estimations. The reports listed below are comparisons of several analyzed components from System Plus Consulting. More reports are however available, and over • 60 reports will be released in 2019.The complete list is available at www.systemplus.fr. Telecom & Infrastructure

Patent Reports – by KnowMade • Defense & Aerospace More than describing the status of the IP situation, these analyses provide a missing link between patented technologies and market, technological and business trends. They offer • Linked reports are dealing with the same topic to provide an understanding of the competitive landscape and technology developments from a patent perspective. They include key insights into key IP players, key patents and future • a more detailed analysis. technology trends. For 2019 KnowMade will release over 15 reports.

MEMS & SENSORS RF DEVICES AND TECHNOLOGIES o MARKET AND TECHNOLOGY REPORT o MARKET AND TECHNOLOGY REPORT • Status of the MEMS Industry 2019 - Update • RF GaN Market: Applications, Players, Technology, • Status of the Audio Industry 2019 - New and Substrates 2019 - Update • Uncooled Infrared Imagers and Detectors 2019 – Update • 5G’s Impact on RF Front-End Module and Connectivity • Consumer Biometrics:Technologies and Market Trends 2018 for Cell Phones 2019 – Update • MEMS Pressure Sensor Market and Technologies 2018 • 5G Impact on Wireless Infrastructure 2019 • Gas & Particle Sensors 2018 • Radar and Wireless for Automotive: Market and Technology Trends 2019 - Update o STRUCTURE, PROCESS & COST REPORT • Advanced RF Antenna Market & Technology 2019 - New • MEMS & Sensors Comparison 2019 • RF Standards and Technologies for Connected Objects 2018 • MEMS Pressure Sensor Comparison 2018 o STRUCTURE, PROCESS & COST REPORT • Particle Sensors Comparison 2019 • • Miniaturized Gas Sensors Comparison 2018 RF Front-End Module Comparison 2019 - Update o PATENT REPORT • Automotive Radar RF Chipset Comparison 2018 o • MEMS Foundry Business Portfolio 2019 - New PATENT REPORT • • Miniaturized Gas Sensors 2019 - New Antenna for 5G Wireless Communications 2019 - New • RF Front End Modules for Cellphones 2018 PHOTONIC AND OPTOELECTRONICS • RF Filter for 5G Wireless Communications: Materials and Technologies 2019 o MARKET AND TECHNOLOGY REPORT • RF GaN : Materials, Devices and Modules 2018 • Silicon Photonics and Photonic Integrated Circuits 2019 • LiDARs for Automotive and Industrial Applications 2019 - Update o PATENT REPORT • Silicon Photonics for Data Centers: Optical Transceiver 2019 - New • LiDAR for Automotive 2018

Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019 31 OUR 2019 REPORTS COLLECTION (2/5) 18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

IMAGING MICROFLUIDICS o MARKET AND TECHNOLOGY REPORT o MARKET AND TECHNOLOGY REPORT • Status of the CIS Industry 2019: Technology • Status of the Microfluidics Industry 2019 - Update and Foundry Business - Update • Next Generation Sequencing & DNA Synthesis - Technology, • Imaging for Automotive 2019 - Update Consumables Manufacturing and Market Trends 2019 - New • Neuromorphic Technologies for Sensing 2019 - Update • Organ-on-a-Chip Market & Technology Landscape 2019 - Update • Status of the CCM and WLO Industry 2019 – Update • Point-of-Need Testing Application of Microfluidic Technologies 2018 • 3D Imaging & Sensing 2018 • Liquid Biopsy: from Isolation to Downstream Applications 2018 • MachineVision for Industry and Automation 2018 • Chinese Microfluidics Industry 2018 • Sensors for Robotic Vehicles 2018 o PATENT REPORT o STRUCTURE, PROCESS & COST REPORT • Microfluidic Manufacturing Technologies 2019 – New • Compact Camera Modules Comparison 2019 • CMOS Image Sensors Comparison 2019 INKJET AND ACCURATE DISPENSING o PATENT REPORT o MARKET AND TECHNOLOGY REPORT • Facial & Gesture Recognition Technlogies in Mobile Devices 2019 - New • Inkjet Printheads - Dispensing Technologies • Apple iPhone X Proximity Sensor & Flood Illuminator 2018 & Market Landscape 2019 - Update • Emerging Printing Technologies MEDICAL IMAGING AND BIOPHOTONICS for Microsystem Manufacturing 2019 - New o MARKET AND TECHNOLOGY REPORT • Piezoelectric Materials from Bulk to Thin Film 2019 - New • X-Ray Detectors for Medical, Industrial • Inkjet Functional and Additive Manufacturing for Electronics 2018 and Security Applications 2019- New o STRUCTURE, PROCESS & COST REPORT • Microscopy Life Science Cameras: Market and Technology Analysis 2019 • Piezoelectric Materials from Bulk to Thin Film Comparison 2019 • Ultrasound technologies for Medical, Industrial and Consumer Applications 2018 o PATENT REPORT • Optical Coherence Tomography Medical Imaging 2018

Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019 32 OUR 2019 REPORTS COLLECTION (3/5) 18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

BIOTECHNOLOGIES MEMORY o MARKET AND TECHNOLOGY REPORT o MARKET AND TECHNOLOGY REPORT • CRISPR-Cas9 Technology: From Lab to Industries 2018 • Status of the Memory Industry 2019 - New o PATENT REPORT • MRAM Technology and Business 2019 - New • Personalized Medicine 2019 – New • Emerging Non Volatile Memory 2018 o STRUCTURE, PROCESS & COST REPORT BIOMEMS & MEDICAL MICROSYSTEMS • Memory Comparison 2019 o MARKET AND TECHNOLOGY REPORT o PATENT REPORT • Medical Wearables: Market & Technology Analysis 2019 - New • Magnetoresistive Random-Access Memory (MRAM) 2019 - New • Neurotechnologies and Brain Computer Interface 2018 • 3D Non-Volatile Memory 2018 • BioMEMS & Non-Invasive Sensors: Microsystems for Life Sciences & Healthcare 2018 ADVANCED PACKAGING o PATENT REPORT o MARKET AND TECHNOLOGY REPORT • 3D Cell Printing 2019 - New • Fan Out Packaging Technologies and Market Trends 2019 - Update • Circulating Tumor Cells Isolation 2019 - New • 3D TSV Integration and Monolithic Business Update 2019 - Update • Nanopore Sequencing 2019 - New • Advanced RF SiP for Cellphones 2019 - Update • Status of Advanced Packaging Industry 2019 - Update SOFTWARE AND COMPUTING • Status of Advanced Substrates 2019 - Update o MARKET AND TECHNOLOGY REPORT • Panel Level Packaging Trends 2019 - Update • Artificial Intelligence Computing For Automotive 2019 - New • System in Package (SiP) Technology and Market Trends 2019 - New • Hardware and Software for Artificial Intelligence (AI) • Trends in Automotive Packaging 2018 in Consumer Applications 2019 - Update • Thin-Film Integrated Passive Devices 2018 • From Image Processing to Deep Learning 2019 - Update o STRUCTURE, PROCESS & COST REPORT • xPU (Processing Units) for Cryptocurrency, Blockchain, HPC and Gaming 2019 – New • Advanced RF SiP for Cellphones Comparison 2019

Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019 33 OUR 2019 REPORTS COLLECTION (4/5) 18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

SEMICONDUCTOR MANUFACTURING SOLID STATE LIGHTING o MARKET AND TECHNOLOGY REPORT o MARKET AND TECHNOLOGY REPORT • Nano Imprint Lithography 2019 - New • Status of the Solid State Light Source Industry 2019 - New • Equipment and Materials for Fan Out Packaging 2019 - Update • Edge Emitting Lasers (EELS) 2019 - New • Equipment for More than Moore: Thin Film Deposition • Light Shaping Technologies 2019 - New & Etching 2019 - New • Automotive Advanced Front Lighting Systems 2019 - New • Wafer Starts for More Than Moore Applications 2018 • VCSELs - Technology, Industry and Market Trends 2019 - Update • Polymeric Materials at Wafer-Level • IR LEDs and Laser Diodes – Technology, Applications, for Advanced Packaging 2018 and Industry Trends 2018 • Bonding and Lithography Equipment Market • Automotive Lighting 2018: Technology, Industry and Market Trends for More than Moore Devices 2018 • UV LEDs - Technology, Manufacturing and Application Trends 2018 o STRUCTURE, PROCESS & COST REPORT • LiFi: Technology, Industry and Market Trends 2018 • Wafer Bonding Comparison 2018 o STRUCTURE, PROCESS & COST REPORT o PATENT REPORT • VCSEL Comparison 2019 • Hybrid Bonding for 3D Stack 2019 – New o PATENT REPORT • VCSELs 2018

DISPLAY o MARKET AND TECHNOLOGY REPORT • Next Generation 3D Display 2019 - New • Next Generation Human Machine Interaction (HMI)in Displays 2019 - New • Micro-and Mini-LED Displays 2019 - Update • Technologies And Markets for Next Generation Televisions • Displays & Optical Vision Systems for VR, AR & MR 2018 o PATENT REPORT • MicroLED Displays : Intellectual Property Landscape 2018

Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019 34 OUR 2019 REPORTS COLLECTION (5/5) 18 fields of excellence combined with six markets to provide a complete picture of your industry landscape

POWER ELECTRONICS BATTERY & ENERGY MANAGEMENT o MARKET AND TECHNOLOGY REPORT o MARKET AND TECHNOLOGY REPORT • Power SiC: Materials, Devices and Applications 2019 - Update • Status of the Rechargeable Li-ion Battery Industry 2019 - New • Power Electronics for EV/HEV and e-mobility: • Li-ion Battery Packs for Automotive and Stationary Storage Market, Innovations and Trends 2019 - Update Applications 2019 - Update • Status of the Power Electronics Industry 2019 - Update o PATENT REPORT • Discrete Power Packaging : Material Market • Battery Energy Density Increase: Materials and Technology Trends 2019 - New and Emerging Technologies 2019 - New • Status of the Power ICs Industry 2019 - Update • Solid-State Batteries 2019 - New • Status of the Passive Components for the Power Electronics • Status of the Battery Patents 2018 Industry 2019 - Update • Status of the Inverter Industry 2019 - Update COMPOUND SEMI. • Status of the Power Module Packaging Industry 2019 - Update o MARKET AND TECHNOLOGY REPORT • Wireless Charging Market Expectations • Emerging Compound Semiconductor and Technology Trends 2018 Market & Technology Trends 2019 - New • Power GaN 2018: Epitaxy, Devices, Applications • Status of the Compound Semiconductor Industry 2019 - New and Technology Trends • InP Materials, Devices and Applications 2019 - New o STRUCTURE, PROCESS & COST REPORT • GaAs Wafer and Epiwafer Market: RF, Photonics, • Automotive Power Module Packaging Comparison 2018 LED and PV Applications 2018 • GaN-on-Silicon Transistor Comparison 2019 o PATENT REPORT • SiC Transistor Comparison 2019 • GaN-on-Silicon Substrate: Materials, Devices o PATENT REPORT and Applications 2019 - Update • Power SiC : Materials, Devices and Modules 2019 - New • Power GaN : Materials, Devices and Modules 2019 – Update

Yole Développement, System Plus Consulting and KnowMade, all part of the Yole Group of Companies, are launching a collection of 10 monitors in 2019. The monitors aim to provide updated market, technology and patent data as well dedicated quarterly analyses of the evolution in your industry over the previous 12 months. Furthermore, you can benefit from direct access to the analyst for an on-demand Q&A and discussion session regarding trend analyses, forecasts and breaking news. Topics covered will be compact camera modules (CCMs), advanced packaging, compound semiconductors, microfluidics, batteries, RF and memory.

MARKET MONITOR byYole Développement o COMPOUND SEMI. – NEW This monitor will describe how the compound semiconductor industry is evolving. It A FULL PACKAGE: will offer a close look at GaAs, InP, SiC, GaN and other compounds of interest The monitors will provide the evolution of the market in units, wafer area and revenues. providing wafer volumes, revenues, application breakdowns and momentum. They will also offer insights into what is driving the business and a close look at what is Frequency: Quarterly, starting from Q3 2019 happening will also be covered in it. o CAMERA MODULE – NEW The following deliverables will be included in the monitors: This monitor will provide the evolution of the imaging industry, with a close look at • An Excel database with all historical and forecast data image sensor, camera module, lens and VCM. Volumes, revenues and momentum of companies like Sony, Samsung, Omnivision and OnSemi will thus be analysed. • A PDF slide deck with graphs and comments/analyses covering the expected Frequency: Quarterly, starting from Q3 2019 evolutions o MEMORY – UPDATE o ADVANCED PACKAGING – NEW For the memory industry you can have access to a quaterly monitor, as well as an This monitor will provide the evolution of the advanced packaging platforms. It will additional service, a monthly pricing. Both services can be bought seprately: cover Fan-Out Wafer Level Packaging (WLP), Fan-Out Panel Level Packaging (PLP), • DRAM Service: Including a quarterly monitor and monthly pricing. Wafer-Level Chip Scale Packaging (WLCSP), Flip Chip packaging platforms, and 2.5D and 3D Through Silicon Via (TSV) integration. Frequency: Quarterly, starting from Q3 • NAND Service: Including a quarterly monitor and monthly pricing. 2019

REVERSETECHNOLOGY MONITOR by System Plus Consulting o SMARTPHONES – NEW To stay updated on the latest components, packaging and silicon chip choices of the smartphone makers, System Plus Consulting has created its first Smartphone Reverse Technology monitor. This year, get access to the packaging and silicon content database of at least 20 different flagship smartphones – more than five per quarter. Starting at the beginning of 2019, the monitor will include an Excel database report for each phone and a quarterly comparison.

PATENT MONITOR by KnowMade o Li-ion Batteries Anodes made of lithium metal, silicon, and lithium titanate (LTO); cathodes made of A FULL PACKAGE: Lithium Iron Phosphate (LFP), Nickel-Manganese-Cobalt (NMC), Lithium Nickel Starting at the beginning of the year, the KnowMade monitors include the following Cobalt Aluminium Oxide (NCA), Lithium Nickel Metal Dioxide (LiNiMO2), Lithium deliverables: Metal Phosphate (LiMPO4), and Lithium Metal Tetroxide (LiMO4); electrolytes including liquid, polymer/gel, and solid inorganics; ceramic and other separators; • An Excel file including the monthly IP database of: battery cells including thin film/microbattery, flexible, cylindrical and prismatic; and • New patent applications battery packs and systems. • Newly granted patents o Post Li-ion Batteries • Expired or abandoned patents Battery technologies including redox-flow batteries, sodium-ion, lithiumsulfur, lithium- • Transfer of IP rights through re-assignment and licensing air, and magnesium-ion, and their supply chains, including electrodes, electrolytes, • Patent litigation and opposition battery cells and battery packs/systems. • Quarterly report including a PDF slide deck with the key facts & figures of the o Solid-State Batteries quarter: IP trends over the three last months, with a close look to key IP players and Supply chain including electrodes, battery cells, battery packs/systems and key patented technologies. electrolytes, including polymer, inorganic and inorganic/polymer, inorganic materials, including argyrodites, LIthium Super Ionic CONductor, (LISICONs), Thio-LISICONs, o GaN for Power & RF Electronics sulfide glasses, oxide glasses, perovskites, anti-perovskites and garnets. Wafers and epiwafers, GaN-on-SiC, silicon, sapphire or diamond, semiconductor devices such as transistors, and diodes, devices and applications including converters, o RF Acoustic Wave Filters rectifiers, switches, amplifiers, filters, and Monolothic Microwave Integrated Circuits Including Surface Acoustic Wave (SAW), Temperature Compensated (TC)- SAW, Bulk (MMICs), packaging, modules and systems. Acoustic Wave- Free-standing Bulk Acoustic Resonator (BAWFBAR), BAW-Solidly- Mounted Resonator (BAW-SMR), and Packaging. o GaN for Optoelectronics & Photonics Wafers and epiwafers, GaN-on-sapphire, SiC or silicon; semiconductor devices such o RF Power Amplifiers as LEDs and lasers; and applications including lighting, display, visible communication, Including Low Noise Amplifiers, Doherty Amplifiers, Packaging, and Millimeter-Wave photonics, packaging, modules and systems. technology. o RF Front-End Modules o Microfluidics From components to chips and systems, including all applications.

To meet the growing demand for market, ONLINE ONSITE INPERSON technological and business information, i-Micronews Media integrates several tools i-Micronews e-newsletter i-Micronews.com Events Webcasts able to reach each individual contact within its FreeFullPDF.com network. Brand visibility, networking Targeted audience opportunities We will ensure your company benefits from involvement equals clear, Unique, cost-effective ways Today's technology makes it concise perception of your this to reach global audiences. easy for us to communicate company’s message. Online display advertising regularly, quickly, and Webcasts are a smart, campaigns are great strategies inexpensively – but when innovative way of for improving your understanding each other is communicating to a wider product/brand visibility. They critical, there is no substitute targeted audience. Webcasts are also an efficient way to for meeting in-person. Events create very useful, dynamic adapt with the demands of the are the best way to exchange reference material for times and to evolve an effective ideas with your customers, attendees and also for marketing plan and strategy. partners, prospects while absentees, thanks to the increasing your brand/product recording technology. visibility. #15,800+ monthly unique visitors #110 attendees on average #380 registrants per webcast on on i-Micronews.com #7+ key events planned for 2019 average to gain new leads for #10,900+ weekly readers on different topics your business of i-Micronews e-newsletter

Contact: Camille Veyrier ([email protected]), Marketing & Communication Director

o CONSULTING AND SPECIFIC ANALYSIS, REPORT BUSINESS o FINANCIAL SERVICES (in partnership with Woodside Capital • North America: Partners) • Steve LaFerriere, Senior Sales Director for Western US & Canada • Jean-Christophe Eloy, CEO & President Email: [email protected] – + 1 310 600-8267 Email: [email protected] - +33 4 72 83 01 80 • Ivan Donaldson, VP of Financial Market Development • Chris Youman, Senior Sales Director for Eastern US & Canada Email: [email protected] - +1 208 850 3914 Email: [email protected] – +1 919 607 9839 • Japan & Rest of Asia: o CUSTOM PROJECT SERVICES • Takashi Onozawa, General Manager, Asia Business Development • Jérome Azémar, Technical Project Development Director (India & ROA) Email: [email protected] - +33 6 27 68 69 33 Email: [email protected] - +81 34405-9204 • Miho Othake, Account Manager (Japan) o GENERAL Email: [email protected] - +81 3 4405 9204 • Camille Veyrier, Director, Marketing & Communication • Itsuyo Oshiba, Account Manager (Japan & Singapore) Email: [email protected] - +33 472 83 01 01 Email: [email protected] - +81-80-3577-3042 • Sandrine Leroy, Director, Public Relations • Korea: Peter Ok, Business Development Director Email: [email protected] - +33 4 72 83 01 89 / +33 6 33 11 61 55 Email: [email protected] - +82 10 4089 0233 • Email: [email protected] - +33 4 72 83 01 80 • Greater China: Mavis Wang, Director of Greater China Business Development Email: [email protected] - +886 979 336 809 • Europe: Lizzie Levenez, EMEA Business Development Manager Email: [email protected] - +49 15 123 544 182 Follow us on • RoW: Jean-Christophe Eloy, CEO & President, Yole Développement Email [email protected] - +33 4 72 83 01 80