REVIEW published: 25 February 2021 doi: 10.3389/fimmu.2021.642687 Reflections on the Use of an Invertebrate Chordate Model System for Studies of Gut Edited by: Antonio Figueras, Microbial Immune Interactions Consejo Superior de Investigaciones 1 2,3 3,4 1† Cient´ıficas (CSIC), Spain Assunta Liberti *, Ojas Natarajan , Celine Grace F. Atkinson , Paolo Sordino 2,3* Reviewed by: and Larry J. Dishaw Loriano Ballarin, 1 Biology and Evolution of Marine Organisms (BEOM), Stazione Zoologica Anton Dohrn, Naples, Italy, 2 Morsani College of University of Padua, Italy Medicine, Department of Pediatrics, University of South Florida, Tampa, FL, United States, 3 Division of Molecular Genetics, M. Carla Piazzon, Children’s Research Institute, St. Petersburg, FL, United States, 4 Department of Cell Biology, Microbiology, and Molecular Torre de la Sal Aquaculture Institute Biology, University of South Florida, Tampa, FL, United States (IATS), Spain *Correspondence: Assunta Liberti The functional ecology of the gastrointestinal tract impacts host physiology, and its
[email protected]; dysregulation is at the center of various diseases. The immune system, and specifically
[email protected] Larry J. Dishaw innate immunity, plays a fundamental role in modulating the interface of host and microbes
[email protected] in the gut. While humans remain a primary focus of research in this field, the use of diverse †Present address: model systems help inform us of the fundamental principles legislating homeostasis in the Paolo Sordino, fi Biology and Evolution of Marine gut. Invertebrates, which lack vertebrate-style adaptive immunity, can help de ne Organisms (BEOM), Stazione conserved features of innate immunity that shape the gut ecosystem.