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Advances, Retreats and Challenges in Adhesions Research

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Advances, Retreats and Challenges in Adhesions Research ЭЛЕКТРОННЫЙ НАУЧНЫЙ ЖУРНАЛ «INNOVA» 2016 №1 (2) Innova-journal.ru 1 HUMANITARIAN SCIENCES ГУМАНИТАРНЫЕ НАУКИ ЭЛЕКТРОННЫЙ НАУЧНЫЙ ЖУРНАЛ «INNOVA» 2016 №1 (2) Innova-journal.ru Founder: Kursk State Medical University. Publisher: MedTestInfo LLC. Chair of Editoral Board: Victor Lazarenko – Doctor of Medical Sciences, Honoured Doctor of Russian Federation. Vice-Editor: Pavel Tkachenko – Doctor of Medical Sciences. Editor-in-Chief: Viacheslav Lipatov – Doctor of Medical Sciences. Technical Secretary: M. David Naimzada. Editorial Board: Daria Alontceva — Doctor of Physical and Mathematical Sciences, Ust-Kamenogorsk, Kazakhstan. Marina Nikolaevna Belogubova — Doctor of Sociological Sciences, Moscow, Russia. Konstantin Enkoyan — Doctor of Medical and Biological Sciences, Erevan, Armenia. Irina Frishman — Doctor of Pedagogical Sciences, Moscow, Russia. Karl-Iosef Gundermann — Doctor of Sciences, Shetcin, Poland. Vladimir Ivanov — Doctor of Biological Sciences, Kursk, Rossia. Sisakian Khmaiak — Doctor of Medical Sciences Erevan, Armenia. Anatolii Lyzikov – Doctor of Medical Sciences , Gomel, Belorus. Viorel Naku — Doctor of Science, Kishinev, Moldova. Leonid Prokopenko — Doctor of Medical Sciences, Kursk, Russia. David Wiseman — Philosophy Doctor, Dallas, USA. Liu Hung-Wen — Philosophy Doctor, Harbin, China. Editorial team: Elena Budko - Doctor of Pharmacy, Kursk, Russia. Tatiana Vasilenko - Doctor of Psychology, Kursk, Russia. Vasiliy Gavrilyuk - Doctor of Medical Sciences, Kursk, Russia. Vitaliy Zotov - Doctor of Social Sciences, Kursk, Russia. Alexander Konichenko - Doctor of Technical Sciences, Kursk, Russia. Elena Kravtsova - Doctor of Historical Sciences, Kursk, Russia. Alexey Loktionov - Doctor of Medical Sciences, Kursk, Russia. Galina Mal - Doctor of Medical Sciences, Kursk, Russia. Povetkin Sergey - Doctor of Medical Sciences, Kursk, Russia. Irina Privalova- Doctor of Biological Sciences, Kursk, Russia. Maria Solodilova - Doctor of Biological Sciences, Kursk, Russia. Irina Shamara - Candidate of Philological Sciences, Kursk, Russia. Maksim Shatalov - Candidate of Economic Sciences, Voronezh, Russia. Sergey Schavelyov - Doctor of Philosophy, Doctor of Historical Sciences. Kursk, Russia. Official site: http://innova-journal.ru/ Mass-media registration: ElФС77-66290 ISSN: 2500-2937 RISC: 1543-05/2015K DOI: dx.doi.org/10.21626/innova/ Electronic scientific journal Innova accepts for publication results of original researches , scientific surveys, lectures and general-theoretical articles and also other types of scientific papers (by agreement with the Ed- itorial Board). Publication are free of charge for all authors. 3 HUMANITARIAN SCIENCES ГУМАНИТАРНЫЕ НАУКИ ЭЛЕКТРОННЫЙ НАУЧНЫЙ ЖУРНАЛ «INNOVA» 2016 №1 (2) Innova-journal.ru Contents Advances, Retreats and Challenges in Adhesions Research (D. Wiseman) ............................................................................. 7 The experience of using a single-layer intra-abdominal collagen plate in patients with ventral hernias (V.A. Gorskiy, A.S.Sivkov, B.E.Titkov, G.V.Hachatryan, S.O. Schadskiy) ............................................................................................................. 30 Biologically nanostructured coatings based on amorphous carbon and atomically silver (V.F. Kulikovskij, S.V. Shkodkin, O.V. Miroshnichenko, A.V. Ljubushkin, V.V. Fentisov) ...................................................................................... 36 To the question of material’s choice for creation of vascular implants (Literature Review) (V.A.Lipatov, S.V. Lazarenko, D.A. Severinov, E.A. Matveeva) ............................................................................................................ ................44 Polymer implants for reconstructive surge ry (V.A. Zhukovskiy) ............................................................................................... 51 Modern aspects in the treatment of infectious diseases of the anterior segment of the eye (Literature review) (V.I. Baranov, M.V. Medvedeva, V.A. Lipatov, A.A. Novikova, D.M. Yarmamedov) .................................................................. 60 The modern trends of using local applicational blood reestablishing instruments of surgery of abdominal organs (literature review) (V.A. Lipatov, K.A. Sotnikov, M.P. Ershov, A.A. Ushanov, N.V. Abrosimova, Y.E. Konstantinova) ..... 64 Experimental study of hemostatic effect Mezogelya as the combined effect of the drug in abdominal surgery (D.S. Soldatova, A.I. Bezhin, A.N. Majstrenko) ......................................................................................................................................... 70 Selection of fixing method for tension-free hernioplasty (K.A. Shemyatovsky, D.L. Titarov, A.V. Protasov, A.U. Kalinichenko) ................................................................................................................................................................................. 73 «Imaplant», «Implantat» or «Implantant»? Particular Questions of Surgical Terminology (V.A. Lipatov)....................79 Author Rules .......................................................................................................................................................................................... 83 5 HUMANITARIAN SCIENCES ГУМАНИТАРНЫЕ НАУКИ НАУЧНЫЙ ЭЛЕКТРОННЫЙ ЖУРНАЛ «INNOVA» №2 (3) SCIENTIFIC ELECTRONIC JOURNAL «INNOVA» №2 (3) innova-journal.ru Прорывы, провалы и вызовы в исследованиях спаек Advances, Retreats and Challenges in Adhesions Research David M. Wiseman1 — PhD, MRPharmS Summary The purpose of this paper is to review the progress being made to tackle adhesions, both in terms of advances and «retreats» and to list some of the challenges for the future. 1.1 Are adhesions still an extensive and costly problem? Дэвид М. Вайсман1 — PhD, MRPharmS Advances: Several pharmacoeconomic analyses highlight the cost and burden of adhesions. While certain adhesion barriers reduce adhesion formation, there is evidence that adhesion barriers may improve other surgical outcomes only in some reports. Retreats: The cost of in-patient procedures for adhesions in the USA outpaced that of Keywords other inpatient hospital services by 27% from 1997 to 2013. Adhesions, Adhesiolysis, Adhesion Related Challenges: There were over 350,000 in-patient procedures related to abdominopelvic Disorder, Complex Abdomino-Pelvic and adhesions in 2013 (USA) with aggregate direct costs between $6.2 and $12 billion, Pain Syndrome, CAPPS, ARD, chronic pelvic equivalent to 20%-40% of the entire budget of the US National Institutes of Health pain, bowel obstruction, therapeutic (NIH). These costs do not include outpatient care, work losses, family disruptions, ultrasound. pain management or adhesion-related infertility. While we have achieved some success, the adhesions «community» must emulate the success that groups advocating for other medical conditions have achieved by educating the public that adhesion related complications can happen to anyone undergoing surgery. We still Abbreviations lack reliable data that address whether adhesion barriers improve surgical outcomes. ARD Adhesion Related Disorder Much of the data on the cost and burden of adhesions comes from the USA and also ASBO Adhesive small bowel obstruction Europe. More data are needed to assess the extent of the problem around the world. ASRM American Society for 1.2 Is adhesion-related bowel obstruction still a problem? Reproductive Medicine Advances: Recently issued professional guidelines for the management of obstruction CAP Chronic Abdominal Pain may reflect an increased awareness about adhesions and willingness and ability to CAPPS Complex Abdomino-Pelvic and tackle them. Mortality associated with adhesion-related bowel obstruction has Pain Syndrome declined in the USA from a high of 2421 in 2000 to 1545 in 2013. There is some CPP Chronic Pelvic Pain evidence that adhesion barriers may influence SBO-related measures, but more data CRPS Complex Regional Pain Syndrome are required. FC «Full Conditioning» Method Retreats: Although adhesions research in general has declined, research related to FDA Food & Drug Administration adhesive bowel obstruction is scant. (United States) Challenges: Adhesion related bowel obstruction remains a significant and costly HA Hyaluronic Acid problem with 97,945 (all) and 76,805 (principal) discharges in the US in 2013. These IBS Irritable Bowel Syndrome accounted for 95% of the costs of all abdominopelvic adhesions discharges. We must IC-BPS Interstitial Cystitis-bladder Pain develop better prevention strategies for patients most at risk of obstruction and for Syndrome those who have already obstructed. IUD Intrauterine Device 1.3 Is adhesion-related infertility still a problem? SBO Small Bowel Obstruction Advances: We are beginning to understand the economic impact of treating adhesion- related infertility secondary to other procedures. Retreats: Because of advances in assisted reproductive technologies, little progress has been made in improving adhesion-dependent fertility outcomes after surgery. Challenges: Due to cost and ethical issues of assisted reproductive technologies, adnexal adhesiolysis may be making a resurgence in popularity. 1.4 Is adhesion-related pain still a problem? Advances: We are now clarifying the relationship between adhesions and pain. There is enough of an association between adhesions and pain to justify their prevention initially, but due to central sensitization, neural cross-talk and
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