DAP3 Antibody Cat. No.: 22-624

DAP3 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse, Rat

Recombinant fusion containing a sequence corresponding to amino acids 159-398 IMMUNOGEN: of human DAP3 (NP_387506.1).

TESTED APPLICATIONS: WB

APPLICATIONS: WB: ,1:500 - 1:2000

POSITIVE CONTROL: 1) MCF7

2) Jurkat

3) Mouse kidney

4) Mouse liver

PREDICTED MOLECULAR Observed: 46kDa WEIGHT:

Properties

PURIFICATION: Affinity purification

CLONALITY: Polyclonal

October 1, 2021 1 https://www.prosci-inc.com/dap3-antibody-22-624.html ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: DAP3

DAP3, death associated protein 3, DAP-3, DKFZp686G12159, MGC126058, MGC126059, ALTERNATE NAMES: MRP-S29, MRPS29, bMRP-10, death-associated protein 3, mitochondrial 28S ribosomal protein S29

GENE ID: 7818

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

Mammalian mitochondrial ribosomal are encoded by nuclear and help in protein synthesis within the . Mitochondrial (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical BACKGROUND: properties, which prevents easy recognition by . This encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor factor-alpha, , and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on 1q and 2q.

ANTIBODIES FOR RESEARCH USE ONLY.

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October 1, 2021 2 https://www.prosci-inc.com/dap3-antibody-22-624.html