Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_001424585Cyc: Chryseobacterium sp. Leaf180 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

H + H + H +

F0F1 ATP F0F1 ATP RS12035 RS08675 RS10040 RS04135 RS14805 YidC FeoB RS02005 RS11380 SecA RseP RS13590 RS13175 RS03610 FtsY MscL Rny RS06115 XrtF RS06525 RS11235 SecY RS06950 RS12650 RS01960 RS02020 RS11560 RS07385 RS05370 RS08610 RS08020 CcoN synthase synthase

H + H + H +

RS14085 Carboxylate Degradation Aminoacyl-tRNA Charging tRNA charging α ditrans,octacis- a peptidoglycan with ditrans,octacis- a peptidoglycan L-alanyl-γ-D- UDP-N-acetyl- a [protein]-L- UDP-N-acetyl- -D-muramoyl- D-alanyl-D-alanine H O phosphoenol an L-asparaginyl- an L-cysteinyl- pyruvate decarboxylation to acetyl CoA I undecaprenyldiphospho- (L-alanyl-γ-D-glutamyl- dimer (meso- glutamyl-L-lysyl- α 2 ser sec γ undecaprenyldiphospho- -D-muramoyl- pyruvate Asn Cys a tRNA methionine Secondary Metabolite Biosynthesis mevalonate degradation acetate L-alanyl- -D-glutamyl-L-lysine GTP dGDP [tRNA ] [tRNA ] RS11120 phe a tRNA Phe TCA cycle TCA cycle I (prokaryotic) N-acetyl-(N-acetyl-β-D- L-lysyl-D-alanyl-D- N-acetyl-(N- diaminopimelate D-alanyl-D-alanine L-alanyl-γ-D- peptide- pyruvate conversion a [pyruvate dehydrogenase glucosaminyl)muramoyl- alanine) pentapeptide acetylglucosaminyl) containing) glutamyl-meso-2,6- methionine dehydrogenase to acetyl-CoA bifunctional UDP-N- fluoroacetate and 6 (R)-mevalonate L-alanyl-γ-D-glutamyl-L- muramoyl-L-alanyl-γ- diaminopimeloyl- (S)-S-oxide preQ biosynthesis acetyl-CoA E2 protein] N -lipoyl-L-lysine D-alanyl-D-alanine ribosome aminoacyl- aminoacyl- serine- fluorothreonine biosynthesis 0 complex E1 acetylmuramoyl-tripeptide:D- β reductase Gln phenylalanine- pyruvate acetate lysyl-D-alanyl-D-alanine D-isoglutaminyl-N-( - D-alanyl-D-alanine gln a tRNA component hydroxymethylglutaryl-CoA alanyl-D-alanine ligase/ D-alanyl-D-alanine carboxypeptidase/ biogenesis pyruvate tRNA tRNA -tRNA -tRNA ligase acetate- D-asparaginyl)-L-lysyl- MsrA: msrA RS00220 ser a tRNA ser tRNA asp asp a tRNA Ala ala oxaloacetate subunit beta: reductase, degradative: alanine racemase: carboxypeptidase/ D-alanyl-D-alanine- GTPase kinase: pyk hydrolase: hydrolase: ligase: elongator subunit beta: fluoride -CoA D-alanyl-D-alanine peptide- his a tRNA His thr a tRNA Thr met initiator tRNA Met met lys a tRNA Lys ile a tRNA Ile trp a tRNA Trp gly a tRNA Gly cys a tRNA Cys leu a tRNA Leu glu a tRNA glu tyr a tRNA Tyr pro a tRNA Pro asn tRNA Asn arg a tRNA Arg GTP ASG01_RS13930 ASG01_RS13625 ASG01_RS05130 monofunctional D-alanyl-D-alanine- endopeptidase: dacB D-alanyl-D-alanine Der: der arfB arfB serS tRNA Met ASG01_RS14395 citrate synthase: ligase: acs methionine glutamine-- val Val SAM-dependent biosynthetic endopeptidase: dacB D-alanyl-D-alanine carboxypeptidase/ [+ 5 isozymes] aminoacyl-tRNA aminoacyl-tRNA a tRNA GTP ASG01_RS06925 pyruvate acetyl-CoA UDP-N-acetylmuramoyl- serine- aspartate- alanine- tRNA ligase/ phenylalanine- chlorinase/ malate dehydrogenase dihydrolipoyl HMG-CoA peptidoglycan monofunctional carboxypeptidase/ D-alanyl-D-alanine- pyruvate hydrolase: hydrolase: (S)-S-oxide cyclohydrolase dehydrogenase tripeptide--D-alanyl- D-alanyl-D-alanine an L-seryl- histidine-- threonine- methionine- methionine- lysine- isoleucine-- tryptophan- -tRNA glycine-- cysteine-- -tRNA leucine-- glutamate-- tyrosine-- proline-- -tRNA YqeY domain asparagine- arginine-- -tRNA ligase fluorinase: 7,8- (quinone): mqo dehydrogenase: transglycosylase: biosynthetic D-alanyl-D-alanine- endopeptidase: dacB dGTP ASG01_RS06370 ASG01_RS06370 reductase RS04795 I FolE: folE (acetyl- D- alanine ligase: carboxypeptidase/ H + [tRNA sec ] tRNA ligase: -tRNA -tRNA -tRNA -tRNA tRNA ligase: -tRNA ligase: tRNA ligase: tRNA ligase: ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: ligase: fusion protein: valine--tRNA ligase: -tRNA tRNA ligase: subunit ASG01_RS01270 dihydroneopterin malate dehydrogenase: lpdA mtgA peptidoglycan endopeptidase: dacB GDP phosphate MsrA: msrA transferring) hydroxymethylglutaryl-CoA ASG01_RS10090 D-alanyl-D-alanine- D-alanyl-D-alanine a protein-L- ASG01_RS01125 ligase: thrS ligase: metG ligase: metG ligase: lysS ASG01_RS03900 ligase: trpS serS ASG01_RS06005 ASG01_RS07105 aspS ASG01_RS08615 ASG01_RS08820 ASG01_RS09550 ASG01_RS09975 alaS ASG01_RS12130 ASG01_RS13225 ligase: asnS ASG01_RS13735 alpha: pheS 3'-triphosphate ASG01_RS11680 dihydrolipoyl transglycosylase: endopeptidase: dacB carboxypeptidase/ 5'-deoxy-5'-fluoroadenosine E1 component lyase: ASG01_RS05635 methionine- 6-carboxytetrahydropterin dehydrogenase: Fatty Acid and di-trans,octa-cis mtgA γ Asn Cys (S)-malate citrate subunit α a peptidoglycan with L-alanyl- -D- D-alanyl-D-alanine- asn tRNA cys a tRNA (S)-S-oxide an L-methionyl- synthase: a [pyruvate dehydrogenaselpdA pyruvate a [pyruvate dehydrogenase Lipid Degradation UDP-N-acetyl- -D-muramoyl-L-alanyl- γ -undecaprenyl an L-histidyl- an L-threonyl- an L-methionyl- an L-lysyl- an L-isoleucyl- an L-tryptophanyl- an L-seryl- Gly an L-cysteinyl- an L-aspartyl- an L-leucyl- an L-glutamyl- an L-tyrosyl- an L-prolyl- an L-alanyl- an L-glutaminyl- an L-valyl- an L-asparaginyl- an L-arginyl- an L-phenylalanyl- purine-nucleoside (L-alanyl- -D-glutamyl- glutamyl-L- D-ala endopeptidase: dacB [elongator a glycyl-[tRNA ] 6 alpha: 6pdhA acetoacetate acetyl-CoA γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine a peptidoglycan RS15530 [tRNA His ] [tRNA Thr ] [initiator tRNA Met ] [tRNA Lys ] [tRNA Ile ] [tRNA Trp ] [tRNA ser ] [tRNA Cys ] [tRNA asp ] [tRNA Leu ] [tRNA Glu ] [tRNA Tyr ] [tRNA Pro ] [tRNA Ala ] [tRNA Gln ] [tRNA Val ] [tRNA Asn ] [tRNA Arg ] [tRNA Phe ] phosphorylase: ASG01_RS14040 E2 protein] N - dehydrogenase E2 protein] N -S- L-lysyl-D-alanyl-D- diphosphate a peptidoglycan di-trans,octa-cis lysyl-D-alanine tRNA Met ] oleate β-oxidation with D,D cross- D-ala 6-carboxy-5,6,7,8- dihydrolipoyl-L-lysine complex acetyldihydrolipoyl-L-lysine deoD alanine) pentapeptide dimer (E. faeciums) -undecaprenyl links (meso- UDP-N- tetrahydropterin fumarate hydratase: dihydrolipoamide D-gluconate 5-fluoro-5-deoxy-D- aconitate hydratase: diphosphate diaminopimelate D-ala acetylmuramoyl- ASG01_RS05930 acetyltransferase: degradation oleate ribose 1-phosphate 7-carboxy-7- ASG01_RS04030 containing) L-alanyl-γ-D- Tetrapyrrole Biosynthesis class II fumarate ASG01_RS02255 RS11650 Storage Compound deazaguanine D-gluconate long-chain fatty glutamyl-meso-2,6- synthase QueE: hydratase: fumC Nucleoside and Nucleotide Biosynthesis Biosynthesis fumarate cis-aconitate gluconokinase: acid--CoA ligase: diaminopimeloyl- tetrapyrrole biosynthesis ASG01_RS04235 D-alanine 5-fluoro-5-deoxy-D- aconitate hydratase: ASG01_RS15350 ASG01_RS09715 cyanophycin metabolism I (from glutamate) 7-carboxy-7- succinate D-gluconate superpathway of pyrimidine Polyprenyl Biosynthesis ribulose 1-phosphate ASG01_RS04030 acetyl-CoA 6-phosphate long-chain fatty RS15020 superpathway of guanosine superpathway of pyrimidine deoxyribonucleoside salvage inosine-5'-phosphate biosynthesis I 5-aminoimidazole ribonucleotide biosynthesis I pyrimidine ribonucleosides salvage I deazaguanine dehydrogenase/ acid--CoA ligase: a mature peptidoglycan trans,octacis a protein-L- ribonucleotides de novo biosynthesis N-acetyl-muramoyl-(L- ditrans,octacis- a [bis(guanylyl hydrogen a reduced phosphoenol a 1-acyl-2- a [protein]- nucleotides de novo biosynthesis I asp glu fumarate reductase ASG01_RS11595 a 5,10- a uridine 34 (meso-diaminopimelate γ a lipid II -decaprenyl methionine- di-trans,poly-cis gly alanyl- -D-glutamyl-L- undecaprenyldiphospho- molybdopterin) cys peroxide thioredoxin dADP pyruvate arachidonoyl- L-tyrosine PRPP 2'-deoxycytidine AIR PRPP cytidine glutamate-- iron-sulfur subunit: methylenetetrahydrofolate in tRNA containing) lysyl-D-alanyl-D-alanine) N-acetyl-(N- cofactor sn-glycerol polysaccharide phosphate (R)-S-oxide gln hydrogencarbonate 5-(carboxyamino)imidazole tRNA ligase: -undecaprenyl ASG01_RS08450 oleoyl-CoA CTP biosynthesis peptide- IMP cyanophycin fluoroacetaldehyde acetylglucosaminyl) chaperone]- 3-phosphate nucleoside ribonucleotide synthase: uridine nucleoside ASG01_RS08820 phosphate biosynthesis preQ Secondary Metabolite Degradation D-alanyl-D-alanine thioredoxin- tyrosine methionine amidophosphoribosyltransferase: synthetase: 0 succinate D-threo-isocitrate endolytic muramoyl-L-alanyl- L-cysteine an L-glutamyl-[tRNA Glu ] (2E,6E)-farnesyl tRNA uridine-5- D-alanyl-D-alanine carboxypeptidase/ (R)-S-oxide deaminase: ASG01_RS11570 ASG01_RS01810 kinase: udk deaminase: cphA IPP NADP-dependent γ-D-isoglutaminyl- dependent autokinase: glutamine- IMP diphosphate carboxymethylaminomethyl(34) transglycosylase carboxypeptidase/ D-alanyl-D-alanine- pyruvate reductase ASG01_RS04300 dCMP N5-CAIR β ASG01_RS04300 ADP-forming isocitrate superpathway of β-D- N-(β-D-asparaginyl) thiol ASG01_RS13105 hydrolyzing dehydrogenase: 5-phospho- - gly arg cyanophycin synthesis enzyme MnmG: mnmG MltG: mltG D-alanyl-D-alanine- cysteine endopeptidase: dacB kinase: pyk MsrB: msrB cytidine CMP cytidine glutamyl-tRNA succinate--CoA ligase dehydrogenase: glucuronosides degradation (2E,9Z)- -L-lysyl-D-alanine peroxidase: carbamoyl- guaB (d)CMP kinase: D-ribosylamine primer-L-aspartate tRNA uridine-5- endopeptidase: dacB desulfurase: polysaccharide deaminase: cdd 5-(carboxyamino)imidazole deaminase: cdd reductase: hemA di-trans,poly-cis- subunit beta: sucC ASG01_RS14550 C1 Compound Utilization octadecenoyl-CoA D-alanyl-D-alanine bcp trans,octacis- peptide- phosphate ASG01_RS02050 β carboxymethylaminomethyl(34) a mature peptidoglycan a mature peptidoglycan ASG01_RS10165 biosynthesis ribonucleotide mutase: purE cyanophycin decaprenylcistransferase: 4-fluorothreonine fluoroacetate succinate--CoA ligase a -D-glucuronoside and Assimilation D-alanyl-D-alanine carboxypeptidase/ a CDP-1-acyl- decaprenylphospho- methionine synthase: XMP phosphoribosylamine- (S)-4-amino-5-oxopentanoate synthesis GTPase MnmE: mnmE with (L-alanyl-γ-D- strand (non- monofunctional tyrosine 2'-deoxyuridine dCDP uridine synthetase: uppS subunit alpha: sucD carboxypeptidase/ [+ 2 isozymes] D-alanyl-D-alanine- pyruvate 2-arachidonoyl- β-D-ribofuranose (R)-S-oxide carB carA CAIR -glycine ligase: purD glutamyl-meso-2,6- reducing terminus) biosynthetic an oxidized H O dATP autokinase: formaldehyde D-alanyl-D-alanine- endopeptidase: dacB 2 reductase nucleoside- uridine cphA glutamate-1- di-trans,octa-cis succinyl-CoA 2-oxoglutarate diaminopimeloyl-D- thioredoxin glycerol ASG01_RS10650 5-phosphate glutamine- (S)-3-hydroxy-(9Z) 34 endopeptidase: dacB peptidoglycan a [bis(guanylyl a [protein]- MsrB: msrB thymidine kinase: diphosphate kinase: semialdehyde 2,1- oxidation II a 5-carboxymethylaminomethyluridine carbamoyl hydrolyzing GMP phosphoribosylaminoimidazolesuccinocarboxamide GAR kinase: udk -undecaprenyl -octadecenoyl-CoA a 7,8-dihydrofolate alanine) tetrapeptide transglycosylase: ala molybdopterin) L-tyrosine a [protein]-L- asp ASG01_RS05125 ASG01_RS02525 asp aminomutase: hemL D-glucopyranuronate (glutathione-dependent) in tRNA a N- phosphate synthase: guaA synthase: ASG01_RS01815 cyanophycin diphosphate mtgA cofactor phosphate methionine deoxynucleoside thymidine UMP formaldehyde N-acetyl-muramoyl-(L- D-ala acetylglucosamine- GMP synthase: dCTP phosphoribosylglycinamide undecaprenyl- γ chaperone]-S- kinase: SAICAR 5-aminolevulinate alanyl- -D-glutamyl- D-ala -N-acetylmuramyl- ASG01_RS01160 formyltransferase: purN diphosphate 2-oxoglutarate di-trans,octa-cis sulfanyl-L-cysteine aspartate ASG01_RS14335 cyanophycin 3-oxo-(9Z)- L-lysyl-D-alanine) a peptidoglycan (tetrapeptide) phosphatase: dehydrogenase -undecaprenyl carbamoyltransferase thymidine kinase: adenylosuccinate synthetase: porphobilinogen S-(hydroxymethyl) octadecenoyl-CoA dimer (E. faecium pyrophosphoryl- GMP FGAR ASG01_RS11225 E1 component: aldehydo-D-glucuronate diphosphate catalytic subunit: dUMP ASG01_RS05125 lyase: ASG01_RS14365 pyrimidine deoxyribonucleotides de novo biosynthesis I cphA synthase: hemB di-trans,octa-cis glutathione , tetrapeptide) undecaprenol ASG01_RS01215 acetyl-CoA C- ASG01_RS02935 phosphoribosylformylglycinamidine -undecaprenyl glucuronate glutathione- deoxynucleoside UDP CTP porphobilinogen acyltransferase: guanylate thymidylate AICAR synthase: ASG01_RS14375 arg [cyanophycin]- phosphate isomerase: dependent a [ribosomal an O 4 - an N-terminal- kinase: superpathway of ribonucleotide- ASG01_RS01420 quinoxaline-2- a [protein]- a peptidoglycan Nα,Nε-diacetyl-lysyl- an N-modified a nucleoside a (1->4)- a supercoiled N-carbamoyl- kinase: gmk synthase: L-aspartate uxaC formaldehyde a sulfurated protein S12] methylthymine α L-methionyl-L- a cytidine 34 lys ASG01_RS14335 adenosine nucleotides bifunctional diphosphate reductase: hydroxymethylbilane acetyl-CoA C- aryl-carrier protein carboxyl adenylate L-cysteine dimer (E. faeciums) D-alanyl-D-alanine aminoacyl-[tRNA] triphosphate RNA -D-glucan ATP roseoflavin duplex DNA L-aspartate ASG01_RS04940 FGAM dehydrogenase: [sulfur carrier] L-aspartate 89 in DNA alanyl-[protein] in tRNA Ile2 DNA de novo biosynthesis I phosphoribosylaminoimidazolecarboxamide ASG01_RS13185 CDP synthase: hemC D-fructuronate acyltransferase: 5'-phosphate thymidylate cyanophycin Respiration ASG01_RS03135 helicase GDP formyltransferase/IMP cyclohydrolase: purH ASG01_RS13190 ASG01_RS02120 D-alanyl-D-alanine alpha- dihydroorotase: synthase: ribonucleotide- phosphoribosylformylglycinamidine synthetase: preuroporphyrinogen methylated-DNA-- D-alanyl-D-alanine DNA-directed RecQ: IMP dUDP S-formylglutathione 30S ribosomal acyl carrier protein: carboxypeptidase/ aminoacyl- amylase: type I methionyl tRNA ASG01_RS08005 ASG01_RS12255 asp FAICAR diphosphate reductase: cyclo-ligase: ASG01_RS03205 cphA (7Z)-hexadecenoyl-CoA [protein]-cysteine S- carboxypeptidase/ bifunctional recQ 2-oxoglutarate decarboxylation to succinyl-CoA protein S12 ASG01_RS08355 D-alanyl-D-alanine- tRNA RNA polymerase amyA aminopeptidase: lysidine(34) nucleoside-diphosphate ASG01_RS13185 uroporphyrinogen- methyltransferase: D-alanyl-D-alanine- subunit omega: riboflavin kinase/ (S)-dihydroorotate AIR methylthiotransferase acyl carrier protein: endopeptidase: dacB hydrolase: alpha-amylase: map synthetase ATP- nucleoside- ribonucleotide- bifunctional kinase: ASG01_RS02525 ASG01_RS13190 III synthase: a [2-oxoglutarate D-mannonate ASG01_RS13685 endopeptidase: dacB ASG01_RS04345 FAD synthetase: cyanophycin RimO: rimO ASG01_RS03845 arfB ASG01_RS07760 TilS: tilS dependent diphosphate diphosphate adenylosuccinate phosphoribosylaminoimidazolecarboxamide ASG01_RS05820 dehydrogenase D-alanyl-D-alanine D-alanyl-D-alanine ASG01_RS01600 quinone-dependent dUTP dCDP mannonate methylated-DNA-- [+ 2 isozymes] DNA kinase: reductase: synthase: formyltransferase/IMP cyclohydrolase: purH uroporphyrinogen- E2 protein] N 6 carboxypeptidase/ aminoacyl-tRNA an N-terminal L- xanthine and cyanophycinase: 2-oxoglutarate dehydratase: formate (2E,7Z)- [protein]-cysteine S- carboxypeptidase/ helicase dihydroorotate ASG01_RS10240 nucleoside triphosphate nucleoside-diphosphate a [ribosomal a quinoxaline-2- D-alanyl-D-alanine- hydrolase: a (1->4)- met alanyl-[protein] a lysidine 34 ASG01_RS02525 ASG01_RS13185 xanthosine salvage ASG01_RS00235 III synthase: -lipoyl-L-lysine dehydrogenase an unsulfurated D-alanyl-D-alanine- roseoflavin dehydrogenase: pyrophosphohydrolase: kinase: ASG01_RS02525 uxuA hexadecenoyl-CoA 5'-deoxyadenosine protein S12]-3- methyltransferase: ASG01_RS06370 α maltohexaose Ile2 RecG: recG ASG01_RS13190 IMP ASG01_RS06090 2-oxoglutarate met AMP carboxyl-[aryl- endopeptidase: dacB endopeptidase: dacB -D-glucan in tRNA ASG01_RS06020 mazG cyanophycinase: E1 component: [sulfur carrier] ASG01_RS11840 RNA adenine a single dCTP dehydrogenase 2-dehydro-3- methylsulfanyl- carrier protein] dTMP adenylo-succinate ASG01_RS01145 ASG01_RS01215 89 dinucleotide stranded DNA orotate PRPP dUMP xanthosine uroporphyrinogen-III deoxy-D-gluconate L-aspartate GTP E1 component: a peptidoglycan α ε an uncharged N-β-aspartyl-L-arginine 2-dehydro-3- a [protein]-S- N ,N -diacetyl- an N-modified dGDP adenylosuccinate thymidylate synthase: purine-nucleoside ASG01_RS01215 (S)-3-hydroxy-(7Z) a thymine in DNA tetramer with a D-ala D-ala tRNA deoxygluconokinase: methyl-L-cysteine lysyl-D-alanine amino acid orotate lyase: ASG01_RS04940 phosphorylase: [+ 2 isozymes]a [2-oxoglutarate a [2-oxoglutarate -hexadecenoyl-CoA D,D cross-link phosphoribosyltransferase: dTDP ASG01_RS14365 ASG01_RS00075 (Enterococcus nucleoside- thymidylate synthase: deoD isoaspartyl dehydrogenase dehydrogenase ASG01_RS13505 superpathway of pyrimidine purine deoxyribonucleosides salvage xanthine diphosphate nucleoside- peptidase/L- E2 protein] N 6 E2 protein] N 6 -S- faecium) nucleobases salvage ASG01_RS12255 KDGP kinase: AMP diphosphate kinase: asparaginase: -dihydrolipoyl- succinyldihydrolipoyl- 3-oxo-(7Z)- orotidine 5'- ASG01_RS02525 dTMP 6 γ ASG01_RS02525 uracil ASG01_RS01140 L-lysine L-lysine hexadecenoyl-CoA a 5,10- a 2-thiouridine 34 a [protein]- an O - ditrans,octacis- a [protein]- L-alanyl- -D- a [LuxE]-S- an N-terminal- an organic phosphate uracil 2'-deoxyguanosine 2'-deoxyadenosine bifunctional methylguanine FAD 2-oxoglutarate isochorismate glutamyl-meso-2,6- (long-chain fatty L-methionyl-L- dTTP adenylate kinase: acetyl-CoA C- methylenetetrahydrofolate in tRNA hypoxanthine L-cysteine undecaprenyldiphospho- L-threonine ATP dGDP hydroperoxide dGTP phosphoribosyltransferase: upp deoxynucleoside deoxynucleoside 4-hydroxy-2- PRPP in DNA N-acetyl-(N- diaminopimeloyl- acyl)-L-cysteine seryl-[protein] biotin thiol orotidine-5'- ASG01_RS10250 acyltransferase: ribonucleotide- UMP kinase: kinase: XMP arg asp oxoglutarate D-alanine peroxidase: phosphate dTDP 2-oxoglutarate ASG01_RS01420 acetylglucosaminyl) ASG01_RS14335 ASG01_RS14335 tRNA uridine-5- methylated-DNA-- γ FAD:protein FMN 2-succinyl-5- diphosphate tpx decarboxylase: CMP UMP kinase: dehydrogenase aldolase/2- muramoyl-L-alanyl- -D- acyl-CoA type I methionyl nucleoside-diphosphate dGMP dAMP acetyl-CoA C- carboxymethylaminomethyl(34) [protein]-cysteine S- transferase: enolpyruvyl- biotin--[acetyl-CoA- reductase: ASG01_RS13505 phosphorylation ADP ASG01_RS02040 E1 component: dehydro-3-deoxy- hypoxanthine isoglutaminyl-L-lysyl- LD- reductase: aminopeptidase: thioredoxin- guanine and guanosine salvage kinase: ASG01_RS02525 acyltransferase: synthesis enzyme MnmG: mnmG methyltransferase: ASG01_RS00835 6-hydroxy-3- carboxylase] ligase: ASG01_RS13185 ASG01_RS01215 phosphogluconate phosphoribosyltransferase: hpt (glycyl) -D-alanyl-D-alanine carboxypeptidase: ASG01_RS02440 map dependent CMP UDP ASG01_RS02120 5 cyclohexene-1- ASG01_RS13190 UMP guanine and guanosine salvage II ribonucleotide- dTTP aldolase: tRNA uridine-5- ASG01_RS13685 FAD:protein FMN ASG01_RS05185 ASG01_RS06120 thiol (d)CMP kinase: nucleoside-diphosphate 2-oxoglutarate carboxymethylaminomethyl(34) transferase: carboxylic-acid UMP kinase: diphosphate ASG01_RS00080 methylated-DNA-- GDP peroxidase: guanosine ASG01_RS02050 kinase: ASG01_RS02525 dehydrogenase (5Z)-tetradecenoyl-CoA synthesis GTPase MnmE: mnmE monofunctional ASG01_RS02880 synthase: menD a [LuxE]- a long-chain an N-terminal ASG01_RS02040 reductase: [protein]-cysteine S- L-alanyl-γ-D- met bcp purine-nucleoside CDP complex biosynthetic L-cysteine fatty aldehyde L-seryl-[protein] biotinyl-5'- guanosine ASG01_RS13185 UTP D-glyceraldehyde IMP methyltransferase: glutamyl-meso- adenylate an alcohol UDP phosphorylase: nucleoside- dGDP dADP dihydrolipoyllysine- pyruvate peptidoglycan 2-succinyl-5-enolpyruvoyl- D-ala ASG01_RS13190 3-phosphate a 5-aminomethyl-2- ASG01_RS11840 a [protein]-FMN- diaminopimelate deoD CTP synthase: residue a 7,8-dihydrofolate transglycosylase: nucleoside- diphosphate 34 6-hydroxy-3-cyclohexene- guanine ASG01_RS13760 nucleoside- nucleoside- succinyltransferase: (2E,5Z)- thiouridine in tRNA mtgA AMP L-threonine diphosphate kinase: dADP 1-carboxylate diphosphate diphosphate odhB tetradecenoyl-CoA a [protein]-S- kinase: ASG01_RS02525 CTP a guanine in DNA guanine kinase: kinase: methyl-L-cysteine a peptidoglycan di-trans,octa-cis ASG01_RS02525 gln hypoxanthine CTP nucleoside- ASG01_RS02525 ASG01_RS02525 dimer (S. aureus) -undecaprenyl phosphoribosyltransferase: hpt diphosphate UTP hypoxanthine diphosphate kinase: phosphoribosyltransferase: hpt dGTP dATP 2-oxoisovalerate decarboxylation to isobutanoyl-CoA ASG01_RS02525 (3E,5Z)-tetradeca- (S)-3-hydroxy-(5Z) CTP synthase: GMP an [apo BCAA 3,5-dienoyl-CoA -tetradecenoyl-CoA UDP-N-acetyl-α-D-muramoyl- a [DNA]-3'- a 5'-phospho- 3-aci- lipid II (meso UDP-N-acetylmuramoyl- a 2,3,4-saturated a [DNA]-3'- a 5'-phospho- a peptide with ASG01_RS13760 di-trans,octa-cis- + O-phospho- Nucleoside and Nucleotide Degradation L-alanyl-γ-D-glutamyl-L- NAD diaminopimelate L-alanyl-γ-D- aci-nitroethane 1,2-diacyl-sn cys an N-terminal a protein GMP dATP peptidoglycan biosynthesis I Cell Structure Biosynthesis dehydrogenase undecaprenyl phosphate hydroxyl [DNA] nitropropanoate hydroxyl [DNA] L-homoserine dADP lipid IV biosynthesis (E. coli) 6 A E2 protein] N lysyl-D-alanyl-D-alanine containing) glutamyl-meso-2,6- -glycerol 3- L-methionine CTP (meso-diaminopimelate containing) alpha-ketoacid ribonucleotide- ATP- -lipoyl-L-lysine inosine 5'- diaminopimeloyl- phosphate CTP UDP-N-acetyl- a (3R)-3- dehydrogenase guanosine pyrimidine deoxyribonucleotides (3E,5Z)- 3-oxo-(5Z)- DNA nitronate nitronate ATP-dependent diphosphate dependent dihydrolipoyl phosphate phospho-N- D-alanine type I methionyl α-D-glucosamine hydroxytetradecanoyl- UDP-N-acetyl- subunit alpha/beta: nucleotides dephosphorylation tetradecadienoate tetradecenoyl-CoA ligase monooxygenase: peptidoglycan monooxygenase: DNA ligase: cystathionine reductase: Clp protease dehydrogenase: degradation acetylmuramoyl- gamma-synthase: aminopeptidase: Aromatic Compound UDP-N-acetylglucosamine [acp] α-D-glucosamine ASG01_RS09935 degradation III nucleoside triphosphate acetyl-CoA C- D: ligD ASG01_RS15450 synthetase: ASG01_RS15450 ASG01_RS01735 ASG01_RS13185 ATP-binding Biosynthesis lpdA pentapeptide- ASG01_RS12355 LD- ASG01_RS11950 map Metabolic Regulator 1-carboxyvinyltransferase: pyrophosphohydrolase: acyltransferase: [+ 2 isozymes] nitronate nitronate ASG01_RS13190 subunit acyl-ACP--UDP-N- lipid IV biosynthesis (P. putida) dihydrolipoyl IMP transferase: carboxypeptidase: ClpX: clpX Biosynthesis murA A GMP mazG ASG01_RS01420 monofunctional chorismate biosynthesis I dehydrogenase: IMP ASG01_RS04750 monooxygenase: monooxygenase: ADP α acetylglucosamine O- 5'/3'- dCTP dCMP biosynthetic ASG01_RS05185 [DNA] a peptide UDP-N-acetyl- - an [apo BCAA dehydrogenase: acetyl-CoA C- ASG01_RS09480 ASG01_RS09480 a CDP-2,3,4- ppGpp metabolism acyltransferase: lpxA a (3R)-3- lpdA an [apo BCAA dehydrogenase nucleotidase [DNA] NMN peptidoglycan L-cystathionine met a peptide D-erythrose D-glucosamine- hydroxydecanoyl- UDP-N-acetyl- dehydrogenase guaB acyltransferase: saturated- E2 protein] N 6 -S-[2- SurE: surE undecaprenyl-diphospho-N- UMP AMP transglycosylase: UDP-N-acetyl-α-D- Fatty Acid and Lipid Biosynthesis 4-phosphate enolpyruvate α E2 protein] N 6 XMP nucleoside triphosphate ASG01_RS02120 [unspecified diacylglycerol bifunctional 3-deoxy-7- UDP-3-O-[(3R)-3- [acp] -D-glucosamine guanosine acetylmuramoyl-L-alanyl-γ-D- muramoyl-L-alanyl- pppGpp UDP-N- -dihydrolipoyl- methylpropanoyl]dihydrolipoyl- pyrophosphohydrolase: 3-oxopropanoate nitrite degradation mtgA D-ala acetaldehyde nitrite phosphoheptulonate hydroxymyristoyl]-N- L-lysine (3Z)-dodec- glutamyl-L-lysyl- D-alanyl-D-alanine γ-D-glutamyl-meso- acetylmuramate α acyl-ACP--UDP-N- L-lysine 5'/3'- mazG products] palmitate biosynthesis synthase/chorismate acetyl- -D-glucosamine dUTP dUMP 3-enoyl-CoA 2,6-diaminopimelate fatty acid elongation -- saturated dehydrogenase: acetylglucosamine O- nucleotidase purine-nucleoside lipid II (meso di-trans,octa-cis (type II fatty acid synthase) bifunctional (p)ppGpp mutase type II: bifunctional murB acyltransferase: lpxA SurE: surE phosphorylase: diaminopimelate -undecaprenyl synthetase/guanosine- ASG01_RS02535 UDP-3-O-[3- 3-deoxy- ala UDP-N-acetyl- deoD containing) diphosphate an acetoacetyl-[acp] an acetoacetyl-[acp] 3',5'-bis(diphosphate) 3'- hydroxymyristoyl] N- 2-oxo acid 5-hydroxy-CTP 5-hydroxy-CMP D-arabino- α-D-muramate acetylglucosamine UDP-3-O-[(3R)-3- ATP biosynthesis xanthosine (2E)-dodec- pyrophosphohydrolase: heptulosonate hydroxydecanoyl]- dehydrogenase guanine deacetylase/3- 2-enoyl-CoA UDP-N-acetyl-α-D- a peptidoglycan a mature DNA with adenine:7,8- (2S)- (R)-methylmalonyl- an N-terminal- a [lipoyl-carrier 3-oxoacyl- ASG01_RS02950 7-phosphate UDP-N- glu N-acetyl-α-D- subunit E2: di-trans,octa-cis- a lipid II a peptidoglycan (R)-lactate hydroxyacyl-ACP muramoyl-L-alanyl-γ-D- dimer (S. aureus) peptidoglycan dihydro-8- methylsuccinyl- L-methionyl-L- protein]-N 6 -[(R) [acyl-carrier- ASG01_RS01265 purine-nucleoside undecaprenyl phosphate dGTP (n) acetyl-CoA CoA AMP 3-dehydroquinate acetylmuramate-- dehydratase: glucosamine ADP glutamyl-L-lysyl-D-alanine (meso-DAP oxoguanine mismatch CoA methylmalonyl- valyl-[protein] -dihydrolipoyl]- D-2-hydroxyacid protein] glutamate phosphorylase: synthase: aroB L-alanine ligase: ASG01_RS10570 containing) CoA mutase: L-lysine dihydrolipoyl dehydrogenase: reductase: GTP ppGpp racemase: F0F1 ATP synthase: deoD (S)-3- monofunctional D-alanyl-D-alanine 5'/3'- a 3-oxoacyl-[acp] ASG01_RS04725 UDP-3-O-(3- ASG01_RS01360 dehydrogenase: ASG01_RS02455 fabG ASG01_RS10885 atpB ASG01_RS01310 hydroxydodecanoyl-CoA phospho-N- biosynthetic carboxypeptidase/ A/G-specific 3-oxoadipyl- type I methionyl nucleotidase 3-dehydroquinate hydroxymyristoyl) UDP-3-O-(3- xanthine xanthine methylmalonyl- lpdA D-2-hydroxyacid [+ 2 isozymes] UDP-N-acetyl- Macromolecule Modification ASG01_RS01315 atpH acetylmuramoyl- peptidoglycan dNTP D-alanyl-D-alanine- endolytic adenine CoA aminopeptidase: SurE: surE nucleoside- bifunctional (p)ppGpp -α-D-glucosamine hydroxydecanoyl) ASG01_RS01330 atpG pentapeptide- CoA map dehydrogenase: beta- 3-dehydroquinate α-D-muramoyl- D-glt xanthine:NAD+ xanthine:NAD+ purine ribonucleosides degradation transglycosylase: triphosphohydrolase: dgt endopeptidase: dacB transglycosylase glycosylase: thiolase: dihydrolipoyl a (3R)-3- diphosphate synthetase/guanosine- UDP-3-O-(3- -α-D-glucosamine transferase: mutase: scpA ASG01_RS03350 adenosine ketoacyl- dehydratase: L-alanine tRNA-uridine 2-thiolation F0F1 ATP synthase: oxidoreductase: oxidoreductase: mtgA D-alanyl-D-alanine MltG: mltG mutY pcaF dehydrogenase: hydroxybutanoyl-[acp] kinase: 3',5'-bis(diphosphate) 3'- hydroxymyristoyl) UDP-3-O-(3- ASG01_RS04750 a [lipoyl-carrier pyruvate ACP ASG01_RS06615 and selenation (bacteria) ASG01_RS01605 ASG01_RS02735 ASG01_RS02735 3-oxododecanoyl-CoA carboxypeptidase/ succinyl-CoA an N-terminal lpdA ASG01_RS02525 glucosamine N- hydroxymyristoyl) 6 3-hydroxyacyl- synthase 3-ketoacyl-ACP pyrophosphohydrolase: UDP-N- ASG01_RS01610 di-trans,octa-cis a mature GlcNAc-1,6- met protein]-N -[(R 3-dehydroshikimate acyltransferase: glucosamine N- adenosine a peptidoglycan triphosphate D-alanyl-D-alanine- an apurinic site 4-methyl-3- L-valyl-[protein] ACP dehydratase: II: fabF reductase: ASG01_RS02950 acetylmuramoyl- ATP urate urate acetyl-CoA C- undecaprenyl-diphospho-N UMP -undecaprenyl 2'-deoxyguanosine peptidoglycan anhMurNAc- )-lipoyl]-L-lysine cys endopeptidase: dacB (n) adenine within DNA oxoadipyl-CoA ASG01_RS03860 ASG01_RS10395 L-alanine-- ASG01_RS10540 acyltransferase: acyltransferase: -acetylmuramoyl-L-alanyl-γ- γ beta- diphosphate (meso-DAP L-Ala- -D-Glu- D-glutamate UDP-3-O-(3- ASG01_RS10540 ASG01_RS01420 D-glutamyl-L-lysyl- D-alanine bifunctional ketoacyl- [+ 2 isozymes] cysteine a peptidoglycan containing) DAP-D-Ala GDP ligase: murD hydroxymyristoyl) UDP-3-O-(3- UDP-3-O-[3- ACP desulfurase: acetyl-CoA C- with D,D cross- D-ala a (3R)-3- glucosamine N- hydroxymyristoyl) hydroxymyristoyl] N- a 2,3,4-saturatedsynthase bifunctional shikimate ASG01_RS02730 acyltransferase: link (S. aureus) hydroxyacyl-[acyl- UDP-N-acetyl- acyltransferase: glucosamine N- acetylglucosamine fatty acyl-[acp]II: fabF UDP-3-O-[3- meso- [+ 2 isozymes] xanthosine adenosine inosine guanosine ASG01_RS02120 carrier protein] α-D-muramoyl-L- lpxD acyltransferase: deacetylase/3- hydroxymyristoyl] N- diaminopimelate an [L-cysteine alanyl-D-glutamate UDP-2-N,3-O-bis[(3R)- lpxD decanoyl-CoA an N 6 -L- a methylated (1S,2R)-1- sn-glycero-3- N 4 -(β-N-acetyl- an N-terminal- hydroxyacyl-ACP acetylglucosamine desulfurase]-S- a [protein]- a DNA methyl starch 3-hydroxytetradecanoyl]- UDP-2-N-[(3R)-3- a sulfurated threonylcarbamoyladenine 37 2-oxoglutarate nucleobase C-(indol-3- phospho-N- D-glucosaminyl) a RNA-DNA hybrid acetyl-CoA succinyl-CoA L-methionyl- acetyl-CoA dehydratase: deacetylase/3- sulfanyl-L-cysteine ser L-cysteine phosphotriester IMP shikimate 3- UDP-N- α-D-glucosamine hydroxydodecanoyl]- purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside [sulfur carrier] in tRNA within DNA yl)glycerol (arachidonoyl) -L-asparagine glycyl-[protein] acetyl-CoA ASG01_RS10570 hydroxyacyl-ACP phosphorylase: phosphorylase: phosphorylase: phosphorylase: phosphate acetylmuramoyl- UDP-2,3- 3-O-[(3R)-3- 3-phosphate ethanolamine carboxylase 5'/3'- dehydratase: deoD ribonuclease HII: alpha- 3-phosphoshikimate 1- L-alanyl-D- diacylglucosamine hydroxydecanoyl]- deoD deoD deoD alpha-ketoglutarate- methylated-DNA-- 3-oxoadipyl-CoA type I methionyl biotin carboxyl a (2E)-but-2-enoyl-[acp] ASG01_RS10570 a [TusA sulfur- tRNA (N(6)-L- N(4)-(beta-N- amylase: amyA nucleotidase glutamate--2, 6- α-D-glucosamine (2E)-dec-2-enoyl-CoA dependent tryptophan [protein]-cysteine S- ASG01_RS13750 thiolase: pcaF carrier carboxyvinyltransferase: diphosphatase: α threonylcarbamoyladenosine(37) glycerophosphodiester acetylglucosaminyl) aminopeptidase: SurE: surE diaminopimelate carrier protein]-S- -D-ribose- dioxygenase AlkB: synthase: trpB methyltransferase: ribonuclease alpha-amylase: 3-hydroxyacyl- ASG01_RS08990 ASG01_RS14035 UDP-2,3- peptidoglycan maturation (meso-diaminopimelate containing) -C(2))- methylthiotransferase phosphodiesterase: -L-asparaginase: map protein: accB ACP dehydratase: 5-enolpyruvoyl- ligase: sulfanyl-L-cysteine 1-phosphate ASG01_RS07595 ASG01_RS03535 ASG01_RS13685 HI: rnhA ASG01_RS07760 UDP-2,3- diacylglucosamine MtaB: mtaB ASG01_RS10415 ASG01_RS11130 [+ 3 isozymes] inosine ASG01_RS03860 shikimate 3- ASG01_RS04755 D-ala lipid II (meso UTP and CTP dephosphorylation I methylated-DNA-- a trans-2- diacylglucosamine diphosphatase: [+ 2 isozymes] 3-oxoadipyl-CoA malonyl-CoA a 2,3,4-saturated phosphate diaminopimelate containing) (S)-3- D-glyceraldehyde [protein]-cysteine S- an N-terminal enoyl-[acyl- diphosphatase: ASG01_RS14035 6 a nucleoside 5'- met glucose maltose a butanoyl-[acp] fatty acyl-[acp] chorismate UDP-N-acetyl- D-alanine--D- monofunctional a [TusD sulfur- UTP hydroxydecanoyl-CoA a 2-methylsulfanyl-N -L- 3-phosphate trp methyltransferase: sn-glycerol N-acetyl-β- DNA glycyl-[protein] carrier protein] ASG01_RS06995 UDP-2,3- D-ribose 5- 37 5'-deoxyadenosine an unsulfurated a nucleobase anandamide monophosphate synthase: α-D-muramoyl- alanine ligase: biosynthetic carrier protein]-S- threonylcarbamoyladenine met formaldehyde succinate ASG01_RS11840 3-phosphate asp glucosaminylamine ASG01_RS10915 diacylglucosamine CTP synthase: phosphate in tRNA [sulfur carrier] within DNA beta-ketoacyl- aroC L-alanyl-γ-D- lipid X peptidoglycan sulfanyl-L-cysteine ACP synthase glutamyl-meso-2,6- diphosphatase: transglycosylase: ASG01_RS13760 chorismate D-alanyl-D-alanine ASG01_RS06995 a [protein]-S- II: fabF diaminopimelate lipid-A- mtgA UDP [DNA] CDP-diacylglycerol Amine and CTP 3-oxodecanoyl-CoA methyl-L-cysteine beta-ketoacyl- biotin-carboxyl carrier disaccharide a nascent peptidoglycan biosynthesis I Polyamine lipid X (P. putida) a [TusE sulfur ACP synthase protein assembly bifunctional UDP- synthase: lpxB with (L-alanyl-γ-D-glutamyl- acetyl-CoA C- Biosynthesis 34 carrier protein]-S II: fabF a [biotin carboxyl- N-acetylmuramoyl- lipid A disaccharide lipid-A- meso-2,6-diaminopimeloyl-D- a uridine in tRNA acyltransferase: N 6 -(3-methylbut- an N-terminal- DHAP -sulfanylcysteine + a hypoxanthine a ribonucleoside a negatively putrescine (E. coli) disaccharide alanyl-D-alanine) pentapeptide UMP ASG01_RS01420 cob(II)alamin 2-methylbutanoate O-succinyl-L- menadione NADH H L-methionyl-L- carbonic acid an unfolded carrier protein]-L-lysine tripeptide:D-alanyl- CDP a sulfurated [sulfur carrier] 2-en-1-yl)- ATP in DNA diphosphate supercoiled DNA GMP biosynthesis I 37 homoserine protein a 3-oxohexanoyl-[acp] biotin--[acetyl-CoA- D-alanine ligase/ tetraacyldisaccharide synthase: lpxB tRNA 2- 5'/3'- acetyl-CoA C- adenosine in tRNA threonyl-[protein] ribonucleotide- DNA gyrase/ sn-glycerol carboxylase] ligase: alanine racemase: 4'-kinase: lpxK lipid A D-alanyl-D-alanine D-alanyl-D-alanine thiouridine(34) nucleotidase acyltransferase: diphosphate topoisomerase chaperonin 3-oxoacyl- disaccharide acetate- NADH-quinone DNA-deoxyinosine carbonic GMP reductase: 3-phosphate ASG01_RS06120 arg ASG01_RS05130 carboxypeptidase/ carboxypeptidase/ synthase SurE: surE ASG01_RS02120 tRNA (N6-isopentenyl O-succinylhomoserine type I methionyl reductase: IV subunit A: GroEL: groL [acyl-carrier- lipid IV (E. coli) (P. putida) cob(I)yrinic acid -CoA oxidoreductase: glycosylase: anhydrase: ASG01_RS05105 a [biotin carboxyl- arginine A D-alanyl-D-alanine- D-alanyl-D-alanine- a mature peptidoglycan with CMP ASG01_RS13185 ASG01_RS00950 UDP-N- MnmA: mnmA uridine purine deoxyribonucleosides degradation I adenosine(37)-C2)- a,c-diamide ligase: acs sulfhydrylase: ASG01_RS10740 ASG01_RS14940 aminopeptidase: ASG01_RS06385 protein] carrier protein]-N decarboxylase: tetraacyldisaccharide endopeptidase: dacB endopeptidase: dacB (L-alanyl-γ-D-glutamyl-meso- octanoyl-CoA ASG01_RS13190 acetylmuramoyl- 5'/3'- methylthiotransferase adenosyltransferase: ASG01_RS07065 map a 2'- type I DNA a protein reductase: 6 ASG01_RS10750 -biotinyl-L-lysine ASG01_RS11855 tripeptide--D-alanyl- 4'-kinase: lpxK D-alanyl-D-alanine D-alanyl-D-alanine 2,6-diaminopimeloyl-D-alanyl- a 2-thiouridine 34 MiaB: miaB topoisomerase: IMP fabG a 1-acyl-sn agmatine nucleotidase ASG01_RS11865 (2S)-2- cystathionine nuoF nuoH nuoK deoxyribonucleoside D- alanine ligase: lipid IV carboxypeptidase/ carboxypeptidase/ D-alanine) pentapeptide in tRNA an apurinic site topA A SurE: surE methylbutanoyl- diphosphate gamma-synthase: an N-terminal L- 5'-diphosphate CO H O [+ 2 isozymes] -glycerol 3- 2'-deoxyinosine 2'-deoxyadenosine 2'-deoxyguanosine within DNA 2 2 ASG01_RS10090 (P. putida) D-alanyl-D-alanine- D-alanyl-D-alanine- 6 AMP hypoxanthine phosphate agmatinase: tRNA uridine-5- cytidine N -(3-methylbut-2-en- adenosylcobalamin CoA ASG01_RS11950 met threonyl-[protein] a relaxed DNA a (3R)-3- endopeptidase: dacB endopeptidase: dacB 5'-deoxyadenosine an unsulfurated + 1-acyl-sn-glycerol- a [biotin carboxyl- speB carboxymethylaminomethyl(34) (2E)-oct-2-enoyl-CoA 1-yl)-2-(methylsulfanyl) met triphosphate NAD menadiol hydroxyhexanoyl-[acp] UDP-N-acetyl- 37 [sulfur carrier] 3-phosphate carrier-protein dimer]- synthesis enzyme MnmG: mnmG adenosine in tRNA 6 α a nascent peptidoglycan a nascent peptidoglycan purine-nucleoside purine-nucleoside purine-nucleoside N -biotinyl-L-lysine putrescine -D-muramoyl- succinate 3-hydroxyacyl- acyltransferase: γ γ tRNA uridine-5- phosphorylase: phosphorylase: phosphorylase: L-homocysteine acetyl-CoA L-alanyl- -D- with (L-alanyl- -D-glutamyl- with D,D cross-links (meso- ACP dehydratase: ASG01_RS07175 acetyl-CoA carboxymethylaminomethyl(34) deoD deoD deoD carboxylase glutamyl-meso-2,6- di-trans,octa-cis meso-2,6-diaminopimeloyl- diaminopimelate containing) ASG01_RS03860 [+ 2 isozymes] carboxylase, synthesis GTPase MnmE: mnmE (S)-3- biotin diaminopimeloyl- -undecaprenyl D-alanine) tetrapeptide a 1,2-diacyl- carboxyltransferase a 5-carboxymethylaminomethyl- 2-deoxy-α-D- hydroxyoctanoyl-CoA an N-terminal- bifunctional D-alanyl-D-alanine phosphate a [2-oxoglutarate- guanosine 2251 a dipetide with an N- D-sedoheptulose a (1->4)- sn-glycerol carboxylase 34 a sulfurated 3-methylbutanoate H O an adenosine 37 γ subunit beta: accD L,D-transpeptidase: LD-carboxypeptidase: L,D-transpeptidase: 2-thiouridine in tRNA ribose 1-phosphate DL-allothreonine diphosphate 2 DMAPP L-methionyl-L- -L-glutamyl- gly α IPP UDP-3-O-[3- 3-phosphate subunit: accC a mature peptidoglycan SAM dehydrogenase in 23S rRNA terminal L-aspartate 1-phosphate -D-glucan [sulfur carrier] 6 in tRNA alpha- hydroxymyristoyl] N- phospho-N- ASG01_RS10145 ASG01_RS05185 ASG01_RS10145 with D,D cross-links (meso- E2 protein] N - cysteinyl-[protein] D-alanine 23S rRNA isopentenyl- a [carboxyl-carrier amylase: acetylglucosamine 6 acetylmuramoyl- a mature peptidoglycan octanoyl-L-lysine (guanosine(2251) protein dimer]-N - a nascent peptidoglycan a nascent peptidoglycan with a nascent peptidoglycan diaminopimelate containing) acetate- class II fructose- diphosphate deacetylase/3- pentapeptide- with (L-alanyl-γ-D-glutamyl- 3-oxooctanoyl-CoA RdgB/HAM1 family tRNA (adenosine(37)-N6) -2'-O)- dipeptidase amyA carboxybiotinyl-L-lysine with L,D cross links (meso- (L-alanyl-γ-D-glutamyl-meso- with (L-alanyl-γ-D-glutamyl- a 5-aminomethyl-2- -CoA serine type I methionyl glutathione bisphosphate Delta- hydroxyacyl-ACP a CDP- transferase: meso-2,6-diaminopimeloyl- lipoyl non-canonical -dimethylallyltransferase methyltransferase PepE: pepE alpha-amylase: diaminopimelate containing) 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- thiouridine 34 in tRNA Amino Acid Degradation acetyl-CoA C- ligase: acs hydroxymethyltransferase: aminopeptidase: synthase: aldolase: fbaA isomerase: idi dehydratase: diacylglycerol ASG01_RS04750 D-alanine) tetrapeptide synthase: purine NTP MiaA: miaA RlmB: rlmB ASG01_RS07760 glycine) tetrapeptide acyltransferase: ASG01_RS13135 map ASG01_RS01170 2-O- DMAPP ASG01_RS10570 lipA pyrophosphatase: a (1->4)- L-leucine degradation I ASG01_RS01420 methylguanosine 2251 α-D-glucan undecaprenyldiphospho- L-histidine degradation I L-serine degradation 3-methylbutanoyl- rdgB N 6 -(3-methylbut- a proteinogenic D-erythrose phosphatidylserine and acetyl-CoA C- a [2-oxoglutarate diphosphate an N-terminal L- in 23S rRNA asp DHAP a (2E)-hex-2-enoyl-[acp] fatty acid biosynthesis N-acetylmuramoyl-L- a mature peptidoglycan a mature peptidoglycan with a 5-methylaminomethyl- 5'-deoxyadenosine an unsulfurated AMP CoA acetaldehyde [+ 2 isozymes] 2-en-1-yl)- norophthalmate amino acid RS00575 phosphatidylethanolamine γ acyltransferase: met dehydrogenase gly met cysteinyl-[protein] initiation (type II) alanyl-γ-D-glutamyl-meso with L,D cross-links (meso- (L-alanyl- -D-glutamyl-meso- a mature peptidoglycan 34 [sulfur carrier] 37 2-thiouridine in tRNA leu E2 protein] N 6 adenosine biosynthesis I diaminopimelate containing) 2,6-diaminopimelate) tripeptide with (L-alanyl-γ-D-glutamyl- his ser ASG01_RS02120 -2,6-diaminopimeloyl- branched-chain -lipoyl-L-lysine in tRNA acetyl-CoA meso-2,6-diaminopimeloyl- histidine L-serine + a CDP-diacylglycerol D-alanyl-D-alanine amino acid hexanoyl-CoA phosphate H acetyl-CoA glycine) tetrapeptide ammonia- ammonia-lyase: undecaprenyldiphospho- aminotransferase: carboxylase, muramoylpentapeptide beta-N- a 5-methylaminomethyl- lyase: hutH ASG01_RS11250 RS00570 a hexanoyl-[acp] 2-(S-geranyl) ASG01_RS02490 urocanate 2-aminoprop- RS02980 carboxyltransferase a 3-sn-phosphatidyl- acetylglucosaminyltransferase: 4-methyl-2- 2-enoate 34 GDP-α-D- trans,octacis 10 an N-formyl-L- subunit beta: accD L-serine murG thiouridine in tRNA oxopentanoate an L-methionyl- an N - a 2-oxo α-Kdo a double-stranded D-sedoheptulose a [protein]- beta-ketoacyl- urocanate mannose -decaprenyl methionylaminoacyl- glu a (6S)-5- L-ornithine a peptide with a CTP D-glucopyranose malonyl-CoA lipid II (meso Met formyltetrahydrofolate carboxylate oligonucleotide 1,7-bisphosphate a protein L-histidine ACP synthase hydratase: (2E)-hexenoyl-CoA [initiator tRNA ] leader sequence diaminopimelate phosphate tRNA formyltetrahydrofolate bifunctional glucose 1- ATP- II: fabF ACP S- ASG01_RS14480 oligoribonuclease/ dehydrogenase: containing) a 5-methylaminomethyl- 3-deoxy-manno- class II fructose- dependent zinc RS02990 beta-ketoacyl- malonyltransferase: 3-methylbutanoyl- 4-imidazolone- 2-iminopropanoate polyprenol ornithine- PAP phosphatase ASG01_RS12260 RS15295 an L-1- 2-(Se-phospho) methionyl-tRNA peptide bifunctional octulosonate bisphosphate metalloprotease RS02855 ArsB ACP synthase fabD CoA 5-propanoate monophosphomannose -oxo-acid NrnA: a [protein]- phosphatidylethanolamine 34 formyltransferase: deformylase: folylpolyglutamate cytidylyltransferase: glucose 1- FtsH: hflB selenouridine in tRNA (S)-3- synthase: aldolase: fbaA II: fabF Carbohydrate Biosynthesis imidazolonepropionase: ASG01_RS13380 ASG01_RS10840 synthase/ transaminase: kdsB ASG01_RS08695 dehydrogenase: N-phospho- hydroxyhexanoyl-CoA ASG01_RS06100 a peptide a malonyl-[acp] Amino Acid Biosynthesis ASG01_RS08390 dihydrofolate rocD a nucleoside 5'- ASG01_RS12835 L-histidine a 3-oxooctanoyl-[acp] gluconeogenesis I monophosphate D-glucono- D-erythrose ketoacyl-ACP O-antigen building blocks biosynthesis (E. coli) 3-methylcrotonyl- pyruvate trans,octacis- an N-formyl- synthase: DHAP PRPP biosynthesis a 5-methylaminomethyl- N-formimino- a tetrahydrofolate formate a L-methionylaminoacyl- a leader sequence a peptide CMP-Kdo 1,5-lactone 4-phosphate RS10685 RS12290 L-histidine biosynthesis 34 decaprenylphospho- L-methionyl- ASG01_RS05310 a proteinogenic L-glutamate-5- RS10410 3-oxoacyl- synthase III: ammonia assimilation cycle III 2-selenouridine CoA L-glutamate GDP tRNA L-lysine biosynthesis I L-tryptophan biosynthesis UDP-α-D- α-D- β [initiator tRNA met ] amino acid semialdehyde RS08670 [acyl-carrier- ASG01_RS03175 (S)-malate D-glucopyranose D-ribose 5- in tRNA methylcrotonoyl- -D-mannose galactose glucopyranose formimidoylglutamase: 3-oxohexanoyl-CoA protein] PRPP 6-phosphate phosphate CoA carboxylase: glycine cleavage [+ 2 isozymes] ammonium UDP- 1-phosphate glucose-6- ribose-phosphate ASG01_RS03725 a (6S)-5- reductase: gln glucose-1-phosphate ASG01_RS11100 acetyl-CoA C- asp chorismate malate galactopyranose phosphate pyrophosphokinase: formyltetrahydrofolate fabG an acetoacetyl-[acp] ATP thymidylyltransferase formimidoylglutamase: a [glycine- acyltransferase: aspartate kinase: 2-oxoglutarate glu dehydrogenase: mutase: glf isomerase: ASG01_RS05800 3-methylglutaconyl- phosphoribosyltransferase: UDP-Galf RfbA: rfbA lipoprotein posttranslational modification hutG cleavage complex ASG01_RS01420 RS10430 RS04885 [+ 2 isozymes] ASG01_RS11680 dTDP-α-D-glucose pgi PRPP CoA 6 RS02150 ASG01_RS01920 ASG01_RS12145 NADP-specific glutamine H protein] N -[(R glycine cleavage system 2503 N-acetyl-D-glucosaminyl-N- 34 a thiocarboxylated decaprenyl- 38- D-ribose 5- RS08605 F6P acetyl-CoA C- adenine a uridine a [DNA]-3'- a mismatched a (1->4)-α-D-glucan a uridine D-glucopyranose α-amylose a (3R)-3- glutamate synthetase III: glu )-lipoyl]-L-lysine aminomethyltransferase acetylmuramoyl-L-alanyl-D-glutamyl- [SAMP] C- pyrophosphoryl-(N a protein phosphate 1-(5-phospho- L-aspartyl-4-phosphate a [prolipoprotein]- acyltransferase: in 23S rRNA in tRNA hydroxyl DNA base pair 40 in tRNA hydroxyoctanoyl-[acp] β dehydrogenase: gdhA ASG01_RS05880 oxaloacetate glycine cleavage system GcvT: gcvT 6-carboxy-L-lysyl-D-alanine terminal glycine -acetylglucosamine) DNA 1,4-alpha-glucan RluA family glucose 1- 1,4-alpha-glucan- ribose 5- -D-ribosyl)-ATP glutamine-- L-cysteine ASG01_RS02120 zinc-dependent anthranilate PRPP aminomethyltransferase [+ 2 isozymes] -N-acetylmuramyl- mismatch branching pseudouridine dehydrogenase: branching protein: phosphate 3-hydroxyacyl- bifunctional aspartate- dTDP-4-dehydro- fructose-6- prolipoprotein 23S rRNA exodeoxyribonuclease metalloprotease: pyruvate α HMG-CoA GcvT: gcvT tRNA 2- (pentapeptide) repair protein protein GlgB: glgB synthase: ASG01_RS12835 ASG01_RS12270 isomerase ACP dehydratase: phosphoribosyl- semialdehyde phosphoenolpyruvate 6-deoxy- -D- phosphate diacylglyceryl butanoyl-CoA (adenine(2503)-C(2) LD-carboxypeptidase: III: xth ASG01_RS08435 RS08600 RS13580 ammoniumGMP synthase: gln glucopyranose transaminase [+ 4 isozymes] thiouridine(34) MutS: mutS 1,4-alpha-glucan- ASG01_RS10905 glucose 1- 1,4-alpha-glucan B: rpiB RS14005 ASG01_RS03860 AMP dehydrogenase: anthranilate carboxykinase transferase: lgt hydroxymethylglutaryl- a [glycine- )-methyltransferase ASG01_RS05185 exodeoxyribonuclease D-ribulose RS09985 ASG01_RS01160 dTDP-4- (isomerizing) a [glycine-cleavage synthase DNA mismatch branching protein: [+ 2 isozymes] dehydrogenase: branching a peptide bifunctional cyclohydrolase/ ASG01_RS06260 phosphoribosyltransferase: trpD (ATP): pckA prolipoprotein CoA lyase: cleavage complex RlmN: rlmN III: xth a pseudouridine 38- 5-phosphate [+ 6 isozymes] 6 MnmA: mnmA repair protein MutS: ASG01_RS12270 ASG01_RS12260 protein GlgB: glgB dehydrorhamnose : glmS ASG01_RS05635 6 complex H protein] N - α UDP-3-O-[3- phosphoribosyl- L-aspartate 4- diacylglyceryl H protein] N - N-acetyl-D-glucosaminyl-N- a (1,6)- -D-glucosyl- 40 in tRNA D-glucono- 3,5-epimerase: rfbC D-glucosamine aminomethyldihydrolipoyl- ASG01_RS11640 α amylopectin hydroxymyristoyl] N- ATP diphosphatase semialdehyde transferase: dihydrolipoyl- 2503 (1,4)- -glucan N-(5-phosphoribosyl)-anthranilate phosphoenolpyruvate dTDP-4-dehydro- acetoacetate L-lysine crotonyl-CoA a 2-methyladenine acetylmuramoyl-L-alanyl-D- D-ala a [SAMP] C- a 2-thiouridine 34 a [DNA]-3'- a 2'- a properly matched 1,5-lactone acetylglucosamine HisIE: 6-phosphate ASG01_RS05100 L-lysine 5'-deoxyadenosine 4-hydroxy- β-L-rhamnose in 23S rRNA met glutamyl-6-carboxy-L-lysine terminal glycine in tRNA mono-trans,octa- a peptidoglycan hydroxyl deoxyribonucleoside DNA base pair YajC RS12385 deacetylase/3- ASG01_RS01885 phosphoribosylanthranilate glu phosphoglucosamine a [prolipoprotein]- 5'-monophosphate RS06575 tetrahydrodipicolinate phosphopyruvate dTDP-4- cis-decaprenyl dimer RS05365 hydroxyacyl-ACP β mutase: glmM S-1,2-diacyl-sn- L-methionine degradation 1-(5-phospho- - synthase: isomerase: ASG01_RS03525 hydratase: eno diphosphate (mycobacteria) dehydratase: dehydrorhamnose glyceryl-L-cysteine I (to L-homocysteine) aminomethyl- D-ribosyl)-AMP ASG01_RS12810 1-(2-carboxyphenylamino)-1- α-D-glucosamine (S)-3- ASG01_RS10570 reductase: rfbD transferring (2S,4S)-4- deoxy-D-ribulose 5-phosphate 2-phospho-D-glycerate β 1-phosphate L-glutamate bifunctional dTDP- -L- lipoprotein L-threonine hydroxybutanoyl-CoA 34 an sn-glycero-3- a [protein] N- 527 α 2+ 2+ hydroxy-2,3,4,5- met glycine an N-terminal lysine within a [protein]-S- a uridine α a guanine GDP- -D- (S)-1-pyrroline- phosphoenol Cd CadA Cd phosphoribosyl- indole-3-glycerol rhamnose signal peptidase: degradation II degradation II an L-phenylalanyl- an octanoyl-[acp] cys O-succinyl-L- phospho-N-(acyl) terminal-formyl- a (1->4)- -D-glucan + + a (2E)-oct-2-enoyl-[acp] 2,3-bisphosphoglycerate- methionine dehydrogenase: Phe gcv protein H sulfanyl-L-cysteine in tRNA in 16S rRNA mannose 5-carboxylate a protein pyruvate RS06580 Na RS02185 Na AMP tetrahydrodipicolinate arginyl-[protein] [tRNA ] homoserine 1,4-alpha-glucan GDP-mannose RS00050 phosphate alanine racemization independent ASG01_RS03920 adenosyltransferase: gcvP ethanolamine L-methionine 16S rRNA L-glutamate cyclohydrolase/ 4-hydroxy- α glu branching 4,6-dehydratase: pyruvate synthase TrpC: trpC phosphoglycerate N-acetyl- -D- ASG01_RS03950 thr (guanine(527)-N(7) gamma- endopeptidase phosphoribosyl- tetrahydrodipicolinate an (S-diacyl-sn- [+ 2 isozymes] tRNA 2- protein GlgB: glgB ASG01_RS04605 kinase: pyk Cd 2+ CadA Cd 2+ (1S,2R)-1-C-(indol-3- mutase: glucosamine a lipoprotein SAM threonine acetoacetyl-CoA leucyl/phenylalanyl- lipoyl(octanoyl) cystathionine glycerophosphodiester peptide )-methyltransferase semialdehyde La: lon ATP diphosphatase reductase: dapB ala glyceryl)-L-cysteinyl- thiouridine(34) ASG01_RS02360 1-phosphate signal peptide dehydrogenase: tRNA--protein transferase 1,4-alpha-glucan- 7 RsmG: rsmG GDP-mannose dehydrogenase: potassium- yl)glycerol 3-phosphate synthase gamma-synthase: phosphodiesterase: deformylase: an N - + + HisIE: 4-hydroxy- bifunctional UDP- [apolipoprotein] acetyl-CoA C- LipB: lipB pruA pyruvate K transporting K ASG01_RS03135 transferase: ASG01_RS11950 ASG01_RS10415 ASG01_RS10840 branching protein: 527 4,6-dehydratase: an octanoyl-[acp] tetrahydrodipicolinate N-acetylmuramoyl- asp L-2-amino-3- acyltransferase: MnmA: mnmA methylguanine a peptide RS12120 ATPase ASG01_RS01885 tryptophan synthase: 3-phospho-D-glycerate apolipoprotein N- ASG01_RS04965 ASG01_RS12270 ASG01_RS13040 RS13370 β reductase: dapB tripeptide:D-alanyl- oxobutanoate ASG01_RS01420 a [glycine-cleavage in 16S rRNA glu 1-(5-phospho- -D-ribosyl)- trpB ASG01_RS03535 UDP-N-acetyl- acyltransferase: lnt GDP-4-dehydro- RS09900 beta-ketoacyl- D-alanine ligase/ phosphoglycerate aspartate complex H protein] an N- an N-terminal L- a GlgE-glycogen α 5-[(5-phosphoribosylamino) (S)-2,3,4,5- α-D-glucosamine an N-acyl-(S-diacyl- glycine C- acetyl-CoA C- L-phenylalanyl-L- acyl-carrier protein a [protein]- a 2-thiouridine 34 succinate sn-glycerol formate -D-rhamnose ACP synthase ser kinase: a peptide SAH ammonia- 6 L-cystathionine methylideneamino]imidazole- tetrahydrodipicolinate indole alanine racemase: sn-glyceryl)-L- acetyltransferase: kbl acyltransferase: a tRNA Phe N -octanoyl-L-lysine L-cysteine in tRNA 3-phosphate acylethanolamine methionyl-[protein] RS02285 II: fabF ASG01_RS05155 lyase: aspA arginyl-[protein] 4-carboxamide 2,3,4,5- ASG01_RS05130 cysteinyl-[lipoprotein] ASG01_RS02120 beta-ketoacyl- D-ala adenosylhomocysteinase: RS00055 1-(5-phosphoribosyl)-5- tetrahydropyridine- tryptophan synthase: 13-DPG fumarate gly RS04020 ACP synthase [(5- phosphoribosylamino) ASG01_RS10120 acetyl-CoA 2,6-dicarboxylate N- trpB ASG01_RS03535 RNase III mRNA an N 3 -methyladenine 46 II: fabF glycogen biosynthesis I (from ADP-D-Glucose) an N-terminal an L-phenylalanyl- a proteinogenic a (1->4)-α-D-glucan a guanine a [protein]-L- histidinol D-glucopyranose RS11065 methylideneamino]imidazole-4- succinyltransferase: type I leukotriene-C4 isobutanoate processing in DNA a tripeptide β phenylacetyl-CoA L-homocysteine L-alanine L-lysyl-[protein] [tRNA Phe ] amino acid in tRNA -isoaspartate carboxamide isomerase: hisA ASG01_RS01935 glyceraldehyde- queuosine substrate 1,4-alpha-glucan tRNA protein-L- 2-phenylacetyl- histidinol xylose a 3-oxodecanoyl-[acp] D-glucopyranose 6-phosphate degradation IV RS09905 phosphoribulosylformimino- trp biosynthesis I (de novo) branching (guanosine(46)-N7) isoaspartate(D- CoA dehydrogenase: isomerase: N-succinyl-2-amino- 3-phosphate L-arginine degradation III DNA-3- AICAR-phosphate 6-ketopimelate triose-phosphate dehydrogenase: L-asparagine leucyl/phenylalanyl- acetate--CoA peptidase protein GlgB: glgB -methyltransferase aspartate) O- epoxidase: hisD xylA RS04620 3-oxoacyl- phospho- preQ (arginine decarboxylase/ ala gamma- ribonuclease methyladenine RS13745 L-alanine 0 tRNA--protein ligase: acs T: pepT 1,4-alpha-glucan- TrmB: trmB methyltransferase: paaJ paaC [acyl-carrier- N-succinyldiaminopimelate isomerase: gap sugar mutase: degradation I an N 7 - keto-D-fructose biosynthesis III agmatinase pathway) alanine transferase: glutamyltransferase: ggt III: rnc glycosylase I: branching protein: ASG01_RS14450 paaB paaA his RS14320 protein] imidazole aminotransferase: ASG01_RS11480 D-glyceraldehyde ASG01_RS01560 methylguanine 46 a protein L-β- 2-(1,2-epoxy-1,2- DHAP L-glutamine dehydrogenase: ASG01_RS04965 ASG01_RS10025 ASG01_RS12270 reductase: glycerol ASG01_RS01985 3-phosphate α-D-glucopyranose degradation I arg asn in tRNA isoaspartate dihydrophenyl) preQ ASG01_RS11505 RNase III a proteinogenic LptC fabG phosphate L-homoserine cys 1 arginine an α-(γ-L-glutamyl) isobutanoyl-CoA diphosphate a dipeptide starch α N-succinyl-L,L-2,6- 1-phosphate pyruvate asparaginase: Alcohol Degradation leukotriene-D4 AMP an mRNA fragment -methyl ester acetyl-CoA synthase: biosynthesis cysteine decarboxylase: L-phenylalanyl- -L-amino acid processing an apurinic site amino acid [+ 2 isozymes] diaminopimelate tRNA Phe 3-methyladenine RS06985 desulfurase: glucose-1-phosphate gln ASG01_RS12630 L-lysyl-[protein] a tRNA product mRNA within DNA RS04875 hisF hisH guanosine(34) ASG01_RS11855 a (3R)-3- ASG01_RS02730 class II fructose- adenylyltransferase: GMP synthase: agmatine asp glycerophosphodiester RS14385 asp transglycosylase hydroxydecanoyl-[acp] D-erythro-1- [+ 2 isozymes] bisphosphate ASG01_RS01205 ASG01_RS01160 degradation AICAR aspartate kinase: aldolase: fbaA Tgt: tgt [+ 6 isozymes] 3-hydroxyacyl- (imidazol-4- ala a (1->4)-α-D-glucan ADP-α-D-glucose agmatinase: a nascent peptidoglycan 3-benzyl-3,6 -bis(cysteinyl) 2-deoxy-D-ribose a peptidoglycan 37 a double aldehydo-D- RS12770 a 7-aminomethyl-7- glu a proteinogenic methanethiol O-succinyl-L- guanine [DNA] pyridoxamine yl)-glycerol L,L-diaminopimelate ASG01_RS12145 speB a glycerophosphodiester (meso-DAP containing) glutathione - 6-(hydroxymethyl) dimer (generic) an adenine in DNA Phe ACP dehydratase: deazaguanosine 34 5-phosphate in tRNA stranded DNA 5'-phosphate galacturonate 3-phosphate L-aspartyl- glycogen/starch glycerophosphodiester amino acid homoserine -diketopiperazine Dam family site- tRNA DNA gyrase/ DNA RS06270 ASG01_RS03860 in tRNA glucuronate RS09655 diaminopimelate 4-phosphate β synthase: UDP-α-D-galactofuranose putrescine phosphodiesterase: polymerase pyridoxamine bifunctional -D-fructose 1,6- tRNA preQ1(34) S- endolytic endolytic specific DNA- (guanosine(37)-N1) topoisomerase isomerase: bifunctional epimerase: L-glutamate ASG01_RS12705 biosynthesis ASG01_RS10415 cystathionine deoxyribose- IV: dinB 5'-phosphate RS08040 histidinol- aspartate- bisphosphate transglycosylase transglycosylase (adenine-N6)- -methyltransferase IV subunit A: uxaC UDP-3-O-[3- ASG01_RS03025 biosynthesis III adenosylmethionine sn-glycerol gamma- putative C-S lyase: phosphate oxidase: pdxH phosphatase/ a (1->4)-α-D-glucan gamma-synthase: methyltransferase: 1 TrmD: trmD ASG01_RS00950 [+ 3 isozymes] semialdehyde class 1 fructose- α ribosyltransferase- 3-phosphate MltG: mltG MltG: mltG an N - a 2'- D-tagaturonate RS10645 hydroxymyristoyl] N- imidazoleglycerol- UDP- -D-glucose Carbohydrate Degradation glutamyltransferase: ggt ASG01_RS11950 ASG01_RS14885 aldolase: ASG01_RS14640 meso-diaminopimelate dehydrogenase: bisphosphatase: fbp isomerase QueA: queA methylguanine 37 [+ 2 isozymes] deoxyribonucleoside PLP acetylglucosamine phosphate 2-oxoglutarate 1,4-alpha-glucan UDP-glucose 4- deoC an N 6 -methyladenine a negatively ASG01_RS06260 34 a mature peptidoglycan a nascent peptidoglycan GlcNAc-1,6- in tRNA Phe 5'-monophosphate RS09830 deacetylase/3- dehydratase NADP-specific branching epimerase GalE: galE an epoxyqueuosine a lipid II in DNA supercoiled DNA RS11915 F6P UDP-α-D-galactose D-galactose degradation I (Leloir pathway) with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) an α-(γ-L-glutamyl) succinate 3-benzyl-3,6 -dithio- anhydro-MurNAc- hydroxyacyl-ACP HisB: hisB diaminopimelate L-aspartate 4- glutamate protein GlgB: glgB in tRNA (1,4)-β-D-xylan L-cysteinylglycine met pyruvate D-glyceraldehyde RS03165 meso-2,6-diaminopimeloyl- with GlcNAc terminus -L-amino acid 6-(hydroxymethyl) pentapeptide dehydratase: 3-(imidazol-4- decarboxylase: lysA semialdehyde dehydrogenase: glucose-6- 1,4-alpha-glucan- UDP-galactopyranose tRNA degradation DHAP acetaldehyde 3-phosphate β-D-galactopyranose D-alanine) tetrapeptide -diketopiperazine ASG01_RS10570 yl)-2-oxopropyl homoserine gdhA phosphate branching protein: mutase: glf epoxyqueuosine(34) RS10925 β phosphate lys dehydrogenase: glu isomerase: pgi ASG01_RS12270 reductase QueG: queG galactose a (1->4)- -D-xylan a (2E)-dec-2-enoyl-[acp] UDP-Galf endo-1,4-beta- histidinol- ASG01_RS07060 D-glucopyranose a queuosine 34 mutarotase: UDP-N-acetyl- decaprenyl-diphospho-N- a 2'- 37 a supercoiled cytidine RS03245 xylanase: a [release factor]- a guanine a reduced phosphate 6-phosphate a glycogen in tRNA ASG01_RS00180 α-D-glucosamine acetylmuramoyl-pentapeptide hypoglycin A glutathione deoxyribonucleoside glycerophosphoserine a tRNA precursor a uracil in DNA his a DNA segment [DNA] L-glutamine in tRNA duplex DNA H O cytochrome- c-type L-arginine L-homoserine β ASG01_RS00210 5'-triphosphate peptide chain tRNA UvrD-helicase uridine 2 transaminase: α a (1->4)- -D-xylan cytochrome degradation I -D-galactopyranose release factor (guanosine(37)-N1) domain-containing L-histidine N(alpha) recombinase kinase: udk c oxidase, an oxidized hisC oligosaccharide undecaprenyldiphospho- uracil-DNA (arginase pathway) glycerophosphodiester N(5)-glutamine -methyltransferase protein: -methyltransferase: RecA: recA O cbb3-type c-type RS14570 L-histidinol muramoylpentapeptide beta-N- DNA polymerase IV: glycosylase: 2 a decanoyl-[acyl- glycine biosynthesis I galactokinase: gamma- phosphodiesterase: ribonuclease Z: methyltransferase: TrmD: trmD ASG01_RS04910 egtD a DNA segment CMP cytochrome phosphate tRNA processing acetylglucosaminyltransferase: ASG01_RS15500 ASG01_RS11635 an N 1 - carrier protein] arg galK glutamyltransferase: ggt ASG01_RS10415 ASG01_RS09595 prmC in reverse murG [+ 7 isozymes] methylguanine 37 [+ 3 isozymes] hercynine bifunctional β-D-xylopyranose a [release factor]-N 5 a single beta-ketoacyl- superpathway of L- a polycistronic α-D-galactose in tRNA orientation histidinol- ser UDP-α-D-glucose uracil -methyl-L-glutamine stranded DNA ACP synthase asparagine biosynthesis tRNA precursor 1-phosphate decaprenyl-pyrophosphoryl- sn-glycerol a single-stranded an apyrimidinic phosphatase/ serine UDP hypoglycin B L-cysteinylglycine ser II: fabF L-ornithine (N-acetylglucosamine)-N- [DNA] 3-phosphate mature tRNA oligoribonucleotide site in DNA imidazoleglycerol- hydroxymethyltransferase: beta-ketoacyl- asp acetylmuramyl-(pentapeptide) phosphate ASG01_RS13135 ACP synthase ornithine- gly dehydratase II: fabF -oxo-acid glycogen degradation II HisB: hisB a tRNA precursor a tRNA precursor a [glycine-cleavage a 2'- α an unstable uridine transaminase: asparagine asparagine + a [protein]- - starch with a 5' with a 5' a sulfurated [sulfur carrier] SAM complex H protein] H hydrogencarbonate deoxyribonucleoside glycerophosphoglycerol γ-L-glutamyl-(S)- gly fumarate asp chorismate RecA filament- DNA with lesion a 3-oxododecanoyl-[acp] rocD synthase synthase [DNA] L-glutamate histidinol extension and extension and a a glycogen N 6 -octanoyl-L-lysine 5'-triphosphate 2-aminobutanoate bifunctional 3-deoxy-7- protein-glutamate O- alpha- DNA complex excinuclease uridine L-glutamate-5- (glutamine- (glutamine- a long 3' trailer short 3' extension amylase: DNA repair 3-oxoacyl- phosphoheptulonate methyltransferase ABC subunit kinase: udk histidinol semialdehyde hydrolyzing) hydrolyzing) alpha-glucan carbonic glycerophosphodiester L-aspartate amyA protein RecO: [acyl-carrier- ribonuclease DNA polymerase IV: glutathione synthase/chorismate CheR: UvrC: uvrC dehydrogenase: : asnB : asnB family lipoyl anhydrase: phosphodiesterase: oxidase: ASG01_RS12830 UMP protein] L-glutamate P protein ASG01_RS15500 synthase: mutase type II: a [protein]-L-ASG01_RS02610 alpha-amylase: a stabilized [+ 3 isozymes] hisD phosphorylase: synthase: lipA ASG01_RS06385 ASG01_RS10415 nadB DNA without gamma- asparagine asparagine component: [+ 10 isozymes] ASG01_RS01170 ASG01_RS02535 5 ASG01_RS07760 RecA filament- reductase: glgP glutamate-O a large- lesion fabG histidinal semialdehyde synthase synthase a tRNA rnpA prephenate -methyl-ester DNA complex (glutamine- (glutamine- precursor with a tRNA precursor α branched glucan dehydrogenase: an -limit dextrin a [glycine-cleavage CO H O glycerol sn-glycerol 2-iminosuccinate succinate [+ 2 isozymes] with a short 6 2 2 histidinol pruA hydrolyzing) hydrolyzing) a 5' extension 5'-deoxyadenosine met complex H protein] N an unsulfurated [DNA] 3-phosphate ophthalmate 3' extension UDP-glucose-- 4-alpha- [sulfur carrier] a (3R)-3- dehydrogenase: : asnB : asnB UDP-glucose -[(R)-lipoyl]-L-lysine ribonuclease hexose-1-phosphate glucanotransferase: hydroxydodecanoyl-[acp] hisD glu 4-epimerase P protein uridylyltransferase: ASG01_RS07115 GalE: galE 3-hydroxyacyl- β-D-fructofuranose his asn asn component: ASG01_RS00230 a debranched a [pyruvate dehydrogenase E2 D-glyceraldehyde D-sedoheptulose lipid IV (E. coli) CMP-Kdo sn-glycero-3- a single- a holo [PedN acyl- 1,6-anhydro-N- UDP ACP dehydratase: α-D-glucopyranose 6 A ile val rnpA UDP-α-D-galactose α-limit dextrin a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine 3-phosphate 7-phosphate phosphoethanolamine stranded RNA 1-phosphate acetyl-β-muramate ribonucleotide- ASG01_RS03860 1-phosphate carrier protein] anhydro-N- branched-chain branched-chain diphosphate bifunctional ACP S- acetylmuramic Cofactor, Carrier, and Vitamin Biosynthesis an uncharged transketolase: 3-deoxy-D-manno- glycerophosphodiester polyribonucleotide class II fructose- amino acid amino acid reductase: UDP-3-O-[3- phospho- malonyltransferase: acid kinase: tRNA octulosonic acid phosphodiesterase: nucleotidyltransferase: bisphosphate aminotransferase: aminotransferase: ASG01_RS13185 sugar mutase: α ASG01_RS14985 fabD ASG01_RS10075 hydroxymyristoyl] N- -D- lipoyl synthase: lipA transferase: ASG01_RS09130 a malonyl[PedN N-acetyl-D- ASG01_RS02490 ASG01_RS02490 ASG01_RS13190 [2Fe-2S] iron-sulfur ASG01_RS01560 L-arabinose D-glucopyranose [+ 2 isozymes] ASG01_RS10415 aldolase: fbaA (3S)-3-methyl-2- 3-methyl-2- acetylglucosamine bis(guanylyl molybdopterin) cofactor sulfurylation cytidylyl molybdenum glutathione thiamine diphosphate glucopyranose ASG01_RS08640 acyl-carrier muramate 6- cluster biosynthesis flavin biosynthesis I (bacteria and plants) superpathway of coenzyme A biosynthesis I (bacteria) pyridoxal 5'-phosphate biosynthesis I degradation I oxopentanoate oxobutanoate dUDP deacetylase/3- cofactor sulfurylation biosynthesis biosynthesis D-glucopyranose 1-phosphate protein] phosphate D-ribose 5- D-xylulose a single- hydroxyacyl-ACP D-erythrose 6-phosphate glucokinase: a [pyruvate dehydrogenase α sn-glycerol a nucleoside DHAP D-glyceraldehyde 3-methyl-2- a 5,10- II (Bacillus) 6 37 L-arabinopyranose CMP -Kdo-(2->6)- ethanolamine L-cysteine desulfurase cys cytidylyl molybdenum N -L-threonylcarbamoyladenosine phospho- 5'-deoxyadenosine 6 phosphate 5-phosphate stranded RNA dehydratase: oxobutanoate methylenetetrahydrofolate 4-phosphate L-arabinose ASG01_RS11270 met E2 protein] N -lipoyl-L-lysine an unsulfurated [sulfur carrier] lipid IV (E. coli) 3-phosphate diphosphate GTP cofactor (trioxo) cys glu HMP-PP -modified tRNA biosynthesis A ASG01_RS10570 isomerase: sugar mutase: cysteine D-erythrose- cysteine ASG01_RS01560 a (2E)-dodec- 3-methyl-2-oxobutanoate araA desulfurase: GTP 4-phosphate desulfurase: an [MCD cofactor hydroxymethyltransferase: D-xylose L-ribulose 34 4-(2'- 2-enoyl-[acp] ASG01_RS02730 cyclohydrolase dehydrogenase: ASG01_RS02730 thiamine ATP thr RNase R degradation a DNA containing a ribonucleoside a 3,5,7,9,11,13,15- a cytidine dCDP panB chaperone]-MCD degradation I a 5-L-glutamyl- glycyl-glycine glutathione a single a holo [PedD acyl- carboxyphenyl)- roseoflavin [+ 2 isozymes] II: ribA gap phosphate an amino acid substrate RNA an apurinic/ hepta-oxo- in tRNA 2,5-diamino-6- [+ 2 isozymes] cysteine ribulokinase: [peptide] triphosphate stranded DNA carrier protein] bifunctional ribonucleotide- asp 4-phospho- an [L-cysteine γ-L-glutamyl- D-glucopyranose apyrimidinic site hexadecanoyl-[PKS-acp] tRNA (cytidine(34) 4-oxobutyryl-CoA an S-sulfanyl-[L- (5-phospho-D- desulfurase: thiamine- D-xylose ASG01_RS00165 aldo/keto ACP S- 1,4-dihydroxy- riboflavin kinase/ diphosphate 2-dehydropantoate D-erythronate desulfurase]-S- bis(guanylyl L-cysteine threonylcarbamoyl- 6-phosphate -2'-O)- 2-naphthoyl- reductase: cysteine desulfurase] ribosylamino) aspartate 1- superpathway of tetrahydrofolate biosynthesis ASG01_RS02730 phosphate xylose L-ribulose 5- reductase: malonyltransferase: FAD synthetase: erythronate- sulfanyl-L-cysteine molybdopterin) glutathione AMP synthase: gamma- ribonuclease DNA primase: methyltransferase: CoA synthase: ASG01_RS13185 pyrimidin- decarboxylase: [+ 2 isozymes] kinase: thiL isomerase: phosphate gamma- endonuclease III: ASG01_RS07985 fabD ASG01_RS01600 a dodecanoyl-[acp] 4-phosphate cysteine cofactor synthase: ASG01_RS00970 glutamyltransferase: ggt R: rnr ASG01_RS11495 9-hydroxy-3,5,7,11,13,15- a malonyl- a 2'-O- ASG01_RS02965 ASG01_RS01510 ASG01_RS13190 4(3H)-one ASG01_RS13325 a [cytidylyl molybdenum thiamine xylA glutamyltransferase: ggt ASG01_RS05345 roseoflavin desulfurase: L-ribulose-5- 34 1,4-dihydroxy-2- GTP dehydrogenase: formate ASG01_RS01170 threonylcarbamoyl- D-xylulose hexaoxohexadecanoyl- [PedD acyl- methylcytidine CDP bifunctional ASG01_RS02730 cofactor chaperone]- diphosphate phosphate 4- naphthoyl-CoA 5'-phosphate an S-sulfanyl-[cysteine β ASG01_RS02455 dehydrogenase AMP synthase: γ-L-glutamyl- [PKS-acp] carrier protein] in tRNA beta-ketoacyl- diaminohydroxyphosphoribosylaminopyrimidine -alanine (R)-pantoate cytidylyl molybdenum glutathione epimerase: an α-(5-L- L-cysteinylglycine a diribonucleotide a nucleoside 5'- ssDNA/pppN(pN) desulfurase]-[disordered- [+ 2 isozymes] accessory ASG01_RS11930 glycylglycine a 3'-terminal a 5'-phospho- ACP synthase deaminase/5-amino-6-(5-phosphoribosylamino) GTP (3R)-3-hydroxy-2-oxo- cofactor (sulfo-dioxo) ASG01_RS00170 glutamyl)- monophosphate hybrid a [bis(guanylyl sulfurtransferase a peptide unsaturated sugar [DNA] n -1 II: fabF form scaffold uracil reductase RibD: ribD cyclohydrolase 4 phosphooxybutanoate D-xylulose amino acid laurate protein] complex 5-amino-6-(5- pantoate--beta- molybdopterin) FdhD: fdhD (L-threonylcarbamoyl) D-xylulose beta-ketoacyl- I FolE: folE 3-phosphoserine/ cofactor [bis-MGD cofactor demethylmenaquinol- 5-phosphate phospho-D- alanine ligase: 7,8- phosphohydroxythreonine adenylate 5-phosphate ACP synthase long-chain fatty chaperone]-S- chaperone]- 8 biosynthesis I ribosylamino)uracil ASG01_RS12710 dihydroneopterin transaminase: serC lipoate biosynthesis tRNA (adenosine(37)-N6)- UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N 7,8-dihydrofolate an (S)-2- a cytidine 1402 a uracil 1498 a [protein]-L- II: fabF acid--CoA ligase: sulfanyl-L-cysteine bis-MGD thiamine diphosphate D-glucopyranose maltopentaose NADPH H + coenzyme A a diphthine-[translation a uridine in tRNA pyrazinamide bifunctional 3'-triphosphate all-trans- -acetylmuramoyl-L-alanyl-γ- ω a [cysteine desulfurase]- D-ribulose 4-phosphooxy- and incorporation I biosynthesis I (E. coli) threonylcarbamoyltransferase monoglutamate halocarboxylate in 16S rRNA elongation factor 2] in 16S rRNA proline ( = 180) ASG01_RS11595 diaminohydroxyphosphoribosylaminopyrimidine 1,4-dihydroxy- octaprenyl Detoxification D-glutamyl-L-lysyl- D-alanine 16S rRNA 16S rRNA peptidylprolyl tRNA bifunctional S-sulfanyl-[disordered- 5-phosphate (R)-pantothenate L-threonine complex dimerization a 3-oxotetradecanoyl- long-chain fatty deaminase/5-amino-6-(5-phosphoribosylamino) formate 2-naphthoate diphosphate (cytidine(1402)-2'-O) diphthine-- (uracil(1498)-N(3))- isomerase: dihydrouridine nicotinamidase/ form scaffold 3,4- D-glyceraldehyde an octanoyl-[acp] HMP-PP subunit type 1 TsaB: tsaB undecaprenyldiphospho- 4-alpha- dihydrofolate HAD family [acp] acid--CoA ligase: uracil reductase RibD: ribD 4-hydroxythreonine- pyruvate dehydrogenase reactive oxygen species degradation CoA pyrophosphatase: -methyltransferase: ammonia ligase: methyltransferase: ASG01_RS10995 synthase pyrazinamidase: protein] complex dihydroxy-2- type III 7,8- 3-phosphate [+ 2 isozymes] phenylmercury acetate degradation muramoylpentapeptide beta-N- glucanotransferase: reductase: hydrolase: ASG01_RS09715 5-amino-6-(5- 4-phosphate accessory lipoyl(octanoyl) 1,4-dihydroxy- 6 arsenate ASG01_RS08925 cysteine ASG01_RS12340 rsmI 3 ASG01_RS12620 [+ 6 isozymes] DusB: dusB pncA 3-oxoacyl- butanone-4- pantothenate dihydroneopterin an N -L- acetylglucosaminyltransferase: ASG01_RS07115 ASG01_RS10935 ASG01_RS12925 a 2'-O- a diphthamide- an N - phospho-D- dehydrogenase sulfurtransferase transferase 2-naphthoate 37 detoxification a [protein]-L- a 5,6-dihydrouridine pyrazine-2- desulfurase: threonylcarbamoyladenine 1402 1498 [acyl-carrier- lauroyl-CoA phosphate kinase: 3'-phosphate PdxA: pdxA FdhD: fdhD LipB: lipB thiamine octaprenyltransferase: superoxide II (glutaredoxin) mercuriphenyl murG methylcytidine [translation methyluracil proline (ω = 0) in tRNA carboxylate ASG01_RS02730 ribitylamino)uracil chorismate a [lipoyl-carrier protein] protein] synthase: ASG01_RS04315 phosphate in tRNA acetate in 16S rRNA elongation factor 2] in 16S rRNA 3-amino-1- N 6 -octanoyl-L-lysine menA superoxide dismutase: maltose maltotetraose 5,6,7,8- a (2R)-2- reductase: [+ 2 isozymes] adenosylcobalamin arsenate ditrans,octacis-undecaprenyldiphospho- UDP + 3',5'-ADP 4'-phosphopantetheine an S-sulfanyl-[cysteine ribB (R)-4'- aminodeoxychorismate/ hydroxyacetone 1-deoxy-D-xylulose sulfo-bis(guanylyl thiamine- NADP a halide anion fabG stearate biosynthesis salvage from cobalamin lipoyl ASG01_RS06185 arsenate reductase: N-acetyl-(N-acetylglucosaminyl)muramoyl- tetrahydrofolate hydroxy fatty acid desulfurase]-S- 1-deoxy-L- phosphopantothenate anthranilate synthase 1-phosphate 5-phosphate molybdopterin) phosphate II (bacteria and plants) D-erythro-7,8- synthase: lipA demethylmenaquinol-8 superoxide dismutase: ASG01_RS14340 L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine [+ 2 isozymes] sulfanyl-[disordered- glycero-tetrulose ARP bifunctional component II: cofactor kinase: thiL a (3R)-3- cob(I)alamin dihydroneopterin a [lipoyl-carrier N-end rule pathway I (prokaryotic) ASG01_RS06630 arsenate reductase: 4-phosphate phosphopantothenoylcysteine ASG01_RS03510 pyridoxine 5'- thiamine 2+ form scaffold 6 acetate benzene Hg hydroxytetradecanoyl- protein]-N -[(R)- ASG01_RS03370 α undecaprenyl-diphospho-N-acetylmuramoyl-L- 1402 a palmitoyl-[acp] protein] complex decarboxylase/ dihydroneopterin aminodeoxychorismate phosphate diphosphate leucyl/phenylalanyl- hydrogen peroxide UDP-N-acetyl- -D-glucosamine D-glucopyranose maltohexaose D-xylulose D-erythrose an (R)-2- an (R)-2- a cytidine a D-hexose [acp] dihydrolipoyl]-L-lysine arsenite alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine a holo [BryU acyl- acetoacetyl-CoA citrate CAIR beta-ketoacyl- 6,7-dimethyl-8- phosphopantothenate-- aldolase: folB synthase component synthase: tRNA--protein mercuric reductase: 5-phosphate 4-phosphate halocarboxylate halocarboxylate in 16S rRNA 3-hydroxyacyl- NAD de novo biosynthesis 16S rRNA carrier protein] 3-hydroxybutyryl- 5-(carboxyamino) ACP synthase ribityllumazine cob(II)alamin cysteine ligase CoaBC: coaBC 6-(hydroxymethyl) I: ASG01_RS04535 ASG01_RS11610 bacillithiol biosynthesis transferase: ASG01_RS04035 undecaprenyldiphospho- aconitate glucokinase: ACP dehydratase: II: fabF synthase: I (from aspartate) a [protein] catalase: (cytosine(1402)-N(4) ACP S- CoA imidazole (R)-4'- -7,8-dihydropterin 4-amino-4- an N-terminal ASG01_RS04965 muramoylpentapeptide beta-N- 4-alpha- transketolase: HAD family HAD family malonyltransferase: hydratase: ASG01_RS11270 ASG01_RS03860 a [cysteine cob(I)yrinic acid N-terminal L- ASG01_RS03960 0 )-methyltransferase dehydrogenase: ribonucleotide beta-ketoacyl- ASG01_RS05710 phosphopantothenoyl- arginyl-[protein] arginine dependent Hg acetylglucosaminyltransferase: glucanotransferase: hydrolase: hydrolase: ASG01_RS04030 desulfurase]-(S- a,c-diamide 2-amino-4-hydroxy-6- deoxychorismate pyridoxine 5'-phosphate (S)-malate UDP-N-acetyl- leucyl-L-arginine [+ 2 isozymes] ASG01_RS14985 RsmH: rsmH fabD ASG01_RS14420 mutase: purE bifunctional ACP synthase L-cysteine asp arsenite acid resistance ASG01_RS07115 4 D-hexose 6- hydroxymethyldihydropteridine α-D-glucosamine H O hydroxyl radical murG [+ 2 isozymes] ASG01_RS12925 ASG01_RS12925 an N - a malonyl- (S)-3- D-threo-isocitrate sulfanyl) -[disordered- 6,7-dimethyl-8-(1- adenosyltransferase: 2 1402 UDP-3-O-[3- II: fabF 2 bifunctional diphosphokinase: folK L-aspartate methylcytidine [BryU acyl- hydroxybutanoyl- phosphate AIR a 3-oxooctadecanoyl- form scaffold D-ribityl)lumazine ASG01_RS11865 pyridoxamine hydroxymyristoyl] N- phosphopantothenoylcysteine (7,8-dihydropterin- oxidase: nadB N-acetyl- leucyl/phenylalanyl- O arg in 16S rRNA carrier protein] CoA [acp] protein] complex cob(II)alamin- 5'-phosphate 2 ditrans,octacis-undecaprenyldiphospho-N- acetylglucosamine decarboxylase/ tRNA--protein UDP maltopentaose maltose D-glyceraldehyde an (S)-2- a (2R)-2- riboflavin synthase: [corrinoid 6-yl)methyl 4-aminobenzoate oxidase: pdxH 2-iminosuccinate alpha-D- arginine acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- F6P a halide anion a halide anion deacetylase/3- 3-oxoacyl- phosphopantothenate-- transferase: 3-phosphate hydroxycarboxylate hydroxy fatty acid ASG01_RS08715 adenosyltranferase] diphosphate glucosaminyl a [protein] decarboxylase: alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine hydroxyacyl-ACP [acyl-carrier- cysteine ligase CoaBC: coaBC quinolinate ASG01_RS04965 PLP L-malate an N-terminal N-terminal L- ASG01_RS11855 dehydratase: protein] a [cysteine desulfurase]- riboflavin dihydropteroate synthase synthase L-lysyl-[protein] agmatine 4'-phosphopantetheine leucyl-L-lysine an (S-diacyl-sn- ASG01_RS10570 reductase: [scaffold protein- synthase: folP NadA: nadA an (S)-2- N-acetyl-9-O- 1618 BshA: bshA an L-1- D-glucopyranose a maltodextrin F6P adenine a holo [BryP acyl- a 2'- D-glycerate homogentisate fabG (2Fe-2S)] complex bifunctional cob(I)alamin- glyceryl)-L-cysteinyl- halocarboxylate acetylneuraminate ser a (2E)-tetradec- pantetheine- quinolinate phosphatidylethanolamine in 23S rRNA carrier protein] deoxyribonucleoside [+ 2 isozymes] riboflavin kinase/ [corrinoid 7,8- (S)-malyl N- [apolipoprotein] 23S rRNA deoxynucleoside D-glycerate homogentisate 2-enoyl-[acp] a (3R)-3- FAD synthetase: adenosyltranferase] phosphate α (adenine(1618)-N(6) ACP S- L-serine dihydropteroate carboxylating acetyl- -D- Pentose Phosphate Pathways 4-alpha- fructose-6- HAD family sialate O- kinase: dehydrogenase: 1,2-dioxygenase: hydroxyoctadecanoyl- ASG01_RS01600 cob(I)yrinic acid adenylyltransferase: )-methyltransferase malonyltransferase: ammonia-lyase: bifunctional nicotinate- glucosaminide apolipoprotein N- glucanotransferase: phosphate hydrolase: acetylesterase: ASG01_RS14335 ASG01_RS14460 ASG01_RS12390 [acp] a [co-chaperone]- a,c-diamide coaD RlmF: rlmF fabD a 2'- ASG01_RS11250 FMN folylpolyglutamate nucleotide bacillithiol Inorganic Nutrient Metabolism acyltransferase: lnt ASG01_RS07115 aldolase: fsa ASG01_RS12925 ASG01_RS00200 an N 6 - a malonyl- 4-maleyl- 3-hydroxyacyl- [scaffold protein- adenosyltransferase: 3'-dephospho- pentose phosphate deoxyribonucleoside hydroxypyruvate synthase/ diphosphorylase: biosynthesis folate transformations III (E. coli) methyladenine 1618 [BryP acyl- acetoacetate pyruvate ACP dehydratase: (2Fe-2S)] complex ASG01_RS11865 CoA pathway (oxidative branch) I 5'-monophosphate a myristoyl-[acp] bifunctional dihydrofolate nadC deacetylase thiosulfate oxidation III (multienzyme complex) an N-acyl-(S-diacyl- in 23S rRNA carrier protein] ASG01_RS03860 adenosylcob(III) dephospho- molybdopterin biosynthesis urea cycle a 2-acyl-1-lyso- a maltodextrin maltose D-glyceraldehyde an (S)-2- riboflavin kinase/ synthase: BshB1: bshB1 a tetrahydrofolate D-glucopyranose sn-glyceryl)-L- dihydroxyacetone a halide anion acetate N-acetylneuraminate alamin-[corrinoid CoA kinase: Glycolysis phosphatidylethanolamine 3-phosphate hydroxycarboxylate beta-ketoacyl- bifunctional FAD synthetase: ASG01_RS05310 NaMN (S)-malyl α-D- 6-phosphate cysteinyl-[lipoprotein] a [chaperone-ATP]- adenosyltranferase] ASG01_RS08405 glucose-6- a [SoxY protein]-L-cysteine ACP synthase UDP-3-O-[3- ASG01_RS01600 glucosaminide arg [co-chaperone]- cob(I)yrinic acid 7,8-dihydrofolate cys GTP nicotinate-nucleotide phosphate II: fabF hydroxymyristoyl] N- dihydrofolate reductase: methionine glycolysis III (from glucose) [scaffold protein- FAD a,c-diamide coenzyme A monoglutamate ATP adenylyltransferase: bacillithiol dehydrogenase: a [histone]-N 6 - a plant soluble DNA combined with a long-chain N-acetyl-4-O- acetylglucosamine synthase: metH ammonium + D-glucopyranose + (R)-mevalonate an insertion sequence (2S)- beta-ketoacyl- adenosyltransferase: cysteine ASG01_RS06955 biosynthesis ASG01_RS10935 zwf NAD heteroglycan exogenous DNA to form NADPH H (S)-5-hydroxyisourate D-glycerate L-dopa deacetylase/3- (2Fe-2S)] complex GTP 3',8- 6-phospho acetyl-L-lysine fatty acyl-CoA acetylneuraminate diphosphate element IS30 ethylmalonyl-CoA ACP synthase ASG01_RS11865 desulfurase: cysteine- D-glucopyranose a recombinational junction hydroxyacyl-ACP cyclase nicotinate adenine D-glucono- a [SoxY protein]-S- glutamine- Holliday junction transposase: D-glycerate methylmalonyl- II: fabF ASG01_RS02730 adding diphosphomevalonate hydroxyisourate 4,5-DOPA dehydratase: MoaA: moaA dinucleotide 1,5-lactone glucokinase: sulfosulfanyl-L-cysteine hydrolyzing 4-alpha- resolvase RuvX: ruvX ASG01_RS07455 dehydrogenase: CoA adenosylcobalamin enzyme serine NAD-dependent acyl-CoA sialate O- decarboxylase: hydrolase: uraH dioxygenase a 3-oxohexadecanoyl- a 7,8-dihydrofolate [+ 2 isozymes] (8S)-3',8-cyclo-7,8- NAD(+) 6-phosphogluconolactonase: ASG01_RS11270 carbamoyl- glucanotransferase: [+ 4 isozymes] ASG01_RS14460 epimerase: mce ASG01_RS10570 heme b biosynthesis II NAD salvage pathway I (PNC VI cycle) an [L-cysteine a carboxy-adenylated a 5-methyltetrahydrofolate deacylase: crossover junction reductase: acetylesterase: ASG01_RS11590 extradiol: ygiD [acp] a [chaperone- dihydroguanosine synthase: BshC: bshC a 7,8-dihydrofolate hydroxymethyltransferase: pgl cytochrome c: L-arginino- phosphate ASG01_RS07115 an insertion (S)-2-oxo-4- (2R)- an [2Fe-2S] (oxygen-independent) dihydrofolate desulfurase]-S- [small subunit of glycine cleavage system D-glucopyranose L-ornithine ASG01_RS05280 endodeoxyribonuclease ASG01_RS02440 ASG01_RS00200 hydroxypyruvate a (2E)-octadec- ADP]-[disordered- 5'-triphosphate nadE ASG01_RS13135 ASG01_RS05735 succinate synthase: IPP sequence IS30 with hydroxy-4-carboxy- ethylmalonyl-CoA 4,5-seco-dopa + D-gluconate resolution of recombinationalRuvC: ruvC 3-oxoacyl- 2-enoyl-[acp] cluster protein form scaffold NAD reductase: sulfanyl-L-cysteine molybdopterin synthase] cyclic pyranopterin bacillithiol aminomethyltransferase 6-phosphate integrated transposon 5-ureidoimidazoline bifunctional 5,10- 6-phosphate carB carA a plant soluble junction formation [acyl-carrier- uroporphyrinogen-III ASG01_RS10935 monophosphate NAD + GcvT: gcvT a (6S)-5-formyltetrahydrofolate glucose-6- 2''-O-acetyl- maltose a long-chain protein] complex methylenetetrahydrofolate a [SoxY protein]-S- a [SoxY protein]-S a [histone]-L-lysine nicotinamide heteroglycan acetate N-acetylneuraminate protein] uroporphyrinogen synthase [+ 2 isozymes] NADP-dependent phosphate carbamoyl ADP-ribose of two intact strands a tetrahydrofolate thymidylate synthase: dehydrogenase/5,10-5-formyltetrahydrofolate disulfanyl-L-cysteine -sulfanyl-L-cysteine fatty aldehyde reductase: decarboxylase: hemE MoaC: moaC phosphogluconate isomerase: pgi phosphate ASG01_RS04940 methenyltetrahydrofolatecyclo-ligase: fabG coproporphyrinogen III NAD(+) a thiocarboxylated thymidylate synthase: methylenetetrahydrofolate dehydrogenase: gndA cyclic pyranopterin dipyrromethane cyclohydrolase: ASG01_RS06685 6 a stearoyl-[acp] an [Fe-S cluster [small subunit of D-ribulose F6P a [protein]-N - D-threo-7,8- 4-fumaryl- (1R,6R)-6-hydroxy-2- D-arabinofuranose a uracil 1939 (R)-methylmalonyl- [+ 2 isozymes] synthase: nadE phosphate cofactor biosynthesis ASG01_RS12255 reductase [NAD(P)H]: metF ASG01_RS04240 NAD + D-glucopyranose maltotetraose maltotriose a glucan MeOH a (3R)-3- biosynthesis oxygen-independent molybdopterin synthase] 5-phosphate L-citrulline acetyl-L-lysine dihydroneopterin acetoacetate succinylcyclohexa-2,4- 5-phosphate in 23S rRNA CoA lys nicotinate adenine dinucleotide NMN a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate 6-phosphofructokinase: sulfur 23S rRNA hydroxyhexadecanoyl- chaperone]-ATP coproporphyrinogen an apo-[hydroxymethylbilane a [SoxY protein]-S-(2- diene-1-carboxylate 3-deoxy-8- methylmalonyl- catalase: S-adenosyl-L- pfkA reduction II (via polyphosphate metabolism o-succinylbenzoate (uracil(1939)-C(5)) L-lysine 6- [acp] III oxidase: hemN molybdopterin synthase]-L-cysteine bifunctional 5,10- sulfodisulfanyl)-L-cysteine 4-alpha- 4-alpha- phosphooctulonate CoA ASG01_RS03960 nicotinate-nucleotide methionine salvage II polysulfide) NAD-dependent synthase: transaminase: 3-hydroxyacyl- synthase: β-D-fructose 1,6- glucanotransferase: glucanotransferase: dihydroneopterin fumarylacetoacetase: synthase: kdsA -methyltransferase epimerase: mce [+ 2 isozymes] protoporphyrinogen IX methylenetetrahydrofolate deacylase: ASG01_RS12135 ASG01_RS01985 ACP dehydratase: adenylyltransferase: ASG01_RS02770 bisphosphate S 0 long chain ASG01_RS07115 ASG01_RS07115 aldolase: folB fahA RlmD: rlmD stearate a [hydroxymethylbilane dehydrogenase/5,10- ASG01_RS05280 1939 (S)-methylmalonyl- ASG01_RS03860 ASG01_RS06955 SAH molybdenum NADH repair (prokaryotes) polyphosphate 2-succinylbenzoate KDO-8P a 5-methyluracil formaldehyde allysine menaquinol-11 biosynthesis synthase] ES intermediate folate polyglutamylation methenyltetrahydrofolate CoA cofactor biosynthesis 2 in 23S rRNA bifunctional long-chain fatty adenosylhomocysteinase: molybdopterin cyclohydrolase: class II fructose- all-trans- NaMN nicotinamide hydroxymethylbilane 2''-O-acetyl- maltose maltotriose a glucan D-glucopyranose 6-(hydroxymethyl) glycolaldehyde UDP-3-O-[3- acid--CoA ligase: ASG01_RS10120 ASG01_RS04240 NADH bisphosphate a polysulfide nicotinamide a [protein]-L-lysine acetoacetate fumarate ASG01_RS09715 undecaprenyl 1,4-dihydroxy- molybdopterin synthase: hemC a tetrahydrofolate polyphosphate exopolyphosphatase: ADP-ribose -7,8-dihydropterin hydroxymyristoyl] N- protoporphyrin IX L-homocysteine molybdate aldolase: fbaA diphosphate 2-naphthoate 10 kinase 1: ppk1 ASG01_RS11745 acetylglucosamine long-chain fatty bifunctional a [hydroxymethylbilane an N -formyltetrahydrofolate polysulfide acid--CoA ligase: nicotinate nicotinamidase/ synthase] ES intermediate bifunctional serine reductase deacetylase/3- ferrochelatase: methionine 3 3-methyl-2- a glucosylated 34 a long-linear 1518 2604 55 pyrazinamidase: pncA menaquinol-7 biosynthesis thioredoxin hydroxymethyltransferase: triose-phosphate NrfD: nrfD 5,10-methylene- UDP-α-D-glucose a 5-carboxymethylaminomethyluridine α-D-glucopyranose adenine / a uridine a uridine D-ribulose a ribonucleoside hydroxyacyl-ACP ASG01_RS11595 hemH phosphoribosyltransferase: folylpolyglutamate Leu α 1519 a cytosine in DNA ethanol synthase: metH molybdopterin hydroxymethylbilane isomerase: long chain oxobutanoate tetrahydromethanopterin glycogenin in tRNA -D-glucan adenine in 16S rRNA in 23S rRNA in tRNA 5-phosphate 5'-monophosphate pncB pathway synthase/ ASG01_RS13135 10 dehydratase: all-trans- synthase: hemC an N - (R)-NADHX ASG01_RS11480 a polysulfide tRNA (cytidine(34) 16S rRNA 23S rRNA tRNA DNA cytosine ribulose-phosphate catalase: stearoyl-CoA protoheme adenine dihydrofolate D-glyceraldehyde polyphosphate 5'/3'- ASG01_RS10570 DMKH2-11 nicotinate met 1,4-dihydroxy- molybdate formyltetrahydrofolate bifunctional DHAP -2'-O)- (adenine(1518)-N(6)/ heptaprenyl an oxidized dinucleotide a [hydroxymethylbilane a 5,10- 3-phosphate 3-methyl-2-oxobutanoate glycogen/starch 4-alpha- pseudouridine(2604) pseudouridine(55) methyltransferase: 3-epimerase: ASG01_RS03960 nucleotidase synthase: ADP-dependent methyltransferase: adenine(1519)-N(6))- a (2E)-hexadec- diphosphate 2-naphthoate thioredoxin synthase] ES intermediate bifunctional hydroxymethyltransferase: synthase: glucanotransferase: synthase RluF: rluF synthase TruB: truB ASG01_RS07305 ASG01_RS02520 [+ 2 isozymes] SurE: surE bifunctional 4 ASG01_RS05310 methylenetetrahydrofolate type I menaquinol-10 biosynthesis methionine molybdopterin folylpolyglutamate NAD(P)H-hydrate panB ASG01_RS12705 ASG01_RS02965 ASG01_RS07115 dimethyltransferase a pseudouridine 2604 a pseudouridine 55 a 5-methylcytosine D-xylulose 2-enoyl-[acp] demethylmenaquinone hydroxymethylbilane bifunctional glyceraldehyde- a 5-carboxymethylaminomethyl- acetaldehyde a ribonucleoside adenosyltransferase: synthase/ dehydratase/ 6 RsmA: rsmA1518 5-phosphate molybdotransferase 3-phosphate 34 Leu N -dimethyladenine in 23S rRNA in tRNA in DNA methyltransferase/2- all-trans- ASG01_RS03950 synthase: hemC folylpolyglutamate NAD(P)H-hydrate 2'-O-methyluridine in tRNA hydroxymethylpyrimidine thioredoxin- MoeA: a tetrahydrofolate dihydrofolate a glucosylated a short 1,4- /N 6 -dimethyladenine 1519 long-chain fatty methoxy-6-polyprenyl- decaprenyl 1,4-dihydroxy- tetrahydrofolate salvage from synthase/ dehydrogenase: UDP salvage disulfide ASG01_RS02805 a holo-[hydroxymethylbilane synthase: epimerase: 2-dehydropantoate THMPT glycogenin α-D-glucan in 16S rRNA acid activation 1,4-benzoquinol diphosphate 2-naphthoate 5,10-methenyltetrahydrofolate SAM demethylmenaquinol-7 dihydrofolate gap reductase: synthase] ASG01_RS05310 ASG01_RS03340 methylase UbiE: ubiE 4-amino-2-methyl-5- MoO - synthase: (S)-NADHX a palmitoyl-[acp] a long-chain a 5,10- trxB 2 an N 10 - pyrimidinemethanol bifunctional ASG01_RS05310 13-DPG fatty acid bifunctional methenyltetrahydrofolate molybdopterin 6 menaquinol-11 formyltetrahydrofolate bifunctional an N -L- 1915 3-(4- long-chain fatty bifunctional 5,10- demethylmenaquinone cofactor a generic O-phospho- a pseudouridine hydroxymethylpyrimidine a 5,10- 37 hydroxyphenyl) (R)-mevalonate oxaloacetate a folate ribulose methylglyoxal (S)-malate acid--CoA ligase: methylenetetrahydrofolate methyltransferase/2- ADP-dependent phosphoglycerate polynucleotide substrate threonylcarbamoyladenine in 23S rRNA DMKH2-10 kinase/ methylenetetrahydrofolate L-serine pyruvate ASG01_RS11595 dehydrogenase/5,10- methoxy-6-polyprenyl- a reduced menaquinol-9 biosynthesis menaquinol-6 biosynthesis NAD(P)H-hydrate kinase: in tRNA 23S rRNA dihydrofolate malate menaquinol-8 biosynthesis phosphomethylpyrimidine thiamine tRNA 3-phosphoserine/ mevalonate kinase: citrate synthase: ribulokinase: glyoxalase: methenyltetrahydrofolate 1,4-benzoquinol thioredoxin dehydratase/ ASG01_RS05155 (pseudouridine(1915)- 4-hydroxyphenylpyruvate reductase: dehydrogenase long-chain fatty bifunctional kinase: ASG01_RS09490 diphosphate threonylcarbamoyladenosine phosphohydroxythreonine ASG01_RS01435 ASG01_RS06925 ASG01_RS00165 ASG01_RS02165 palmitate cyclohydrolase: methylase UbiE: ubiE NAD(P)H-hydrate S1/P1 nuclease: N(3))-methyltransferase dioxygenase: hppD ASG01_RS10935 (quinone): mqo acid--CoA ligase: demethylmenaquinone HMP-P salvage III NADP demethylmenaquinol-9 demethylmenaquinol-6 3-phospho-D-glycerate dehydratase: ASG01_RS04365 transaminase: serC epimerase: ASG01_RS01690 6 3 RlmH: ASG01_RS02960 L(or D)-ribulose ASG01_RS09715 demethylmenaquinol-8 10 ASG01_RS04240 a cyclic N -L- an N - (R)-5- 1,2-dihydroxypropane- long-chain fatty a long-chain methyltransferase/2- an N - thiamine menaquinol-7 biosynthesis bifunctional bifunctional ASG01_RS03340 a 7,8-dihydrofolate (R)-lactate oxaloacetate bifunctional threonylcarbamoyladenosine 3-phosphooxypyruvate methylpseudouridine 1915 homogentisate phosphomevalonate 1,2,3-tricarboxylate 5-phosphate acid--CoA ligase: fatty acyl-CoA methoxy-6-polyprenyl- bifunctional formyltetrahydrofolate thiamine demethylmenaquinone demethylmenaquinone 2,3-bisphosphoglycerate- + 37 in tRNA ASG01_RS09715 demethylmenaquinone 1,4-benzoquinol hydroxymethylpyrimidine diphosphokinase: NAD methyltransferase/2- methyltransferase/2- NADH independent in 23S rRNA methyltransferase/2- phosphoribosylglycinamide a 5'-phosphomononucleotide a 5'-phosphooligonucleotide long-chain fatty methylase UbiE: ubiE kinase/ ASG01_RS11860 NAD kinase: methoxy-6-polyprenyl- methoxy-6-polyprenyl- phosphoglycerate methoxy-6-polyprenyl- formyltransferase: purN thiamine acid--CoA ligase: phosphomethylpyrimidine ASG01_RS05405 1,4-benzoquinol 1,4-benzoquinol mutase: 1,4-benzoquinol menaquinol-10 diphosphate ASG01_RS11595 kinase: ASG01_RS09490 a tetrahydrofolate NADP + methylase UbiE: ubiE methylase UbiE: ubiE NADPH repair (prokaryotes) ASG01_RS02360 methylase UbiE: ubiE 2,5-diamino-6-(5- D-sedoheptulose 2'-deoxycytidine menaquinol-9 menaquinol-6 2-amino-6-[1-hydroxyethyl]- a glucosylated glycogenin 3-phenyl-2- uroporphyrinogen-I an α-limit dextrin chloramphenicol D-ribofuranose 15-cis-phytoene palmitoyl-CoA menaquinol-8 HMP-PP 2-phospho-D-glycerate phospho-D-ribitylamino) 7-methyl-7,8-dihydropterin oxopropanoate 7-phosphate NADPH 1,4-alpha-glucan branching deoxynucleoside pyrimidin-4(3H)-one 2-amino-4-hydroxy-6- 4-alpha- phosphoheptose chloramphenicol phytoene bifunctional protein GlgB: glgB 4-hydroxyphenylpyruvate uroporphyrinogen kinase: ribokinase: phosphopyruvate hydroxymethyldihydropteridine glucanotransferase: isomerase: acetyltransferase: desaturase: diaminohydroxyphosphoribosylaminopyrimidine dioxygenase: hppD decarboxylase: hemE ASG01_RS14335 ASG01_RS13210 hydratase: eno diphosphokinase: folK 1,4-alpha-glucan-branching ASG01_RS07115 ASG01_RS14865 ASG01_RS15155 crtI deaminase/5-amino-6-(5-phosphoribosylamino) α dCMP [1-(2-amino-7-methyl-4-oxo- protein: ASG01_RS12270 (2-hydroxyphenyl) a -limit dextrin D-glycero-D-manno- chloramphenicol D-ribofuranose 9,15,9'-tri-cis uracil reductase RibD: ribD coproporphyrinogen I phosphoenolpyruvate 5-amino-6-(5-phospho- 7,8-dihydro-3H-pteridin- a glycogen acetate with short branches heptose 7-phosphate 3-acetate 5-phosphate -ζ-carotene (R)-NADPHX D-ribitylamino)uracil 6-yl)]ethyl diphosphate bifunctional pyruvate ADP-dependent kinase: pyk NAD(P)H-hydrate dehydratase/ pyruvate NAD(P)H-hydrate epimerase: ASG01_RS03340 (S)-NADPHX

bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/ NAD(P)H-hydrate epimerase: ASG01_RS03340

NADPH a reduced a reduced plastocyanin plastocyanin an oxidized an oxidized plastocyanin plastocyanin

cytochrome- RS07585 RS02760 FtsA RS02330 RS05180 RS12780 RS13940 RS01955 RS12645 RS01630 RS01485 SecG RS04225 RS12195 RS13350 CcoN c oxidase, RS13320 RS01240 RS03605 RS03825 RS08470 RS04405 RS13720 RS11990 RS07570 MgtE RS12775 RS02095 RS02220 RS09910 CrcB RS10965 cbb3-type

O 2 H O O 2 2 H O 2 This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.