Compounds with Antiviral, Anti-Inflammatory and Anticancer
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Lack of Influence of Substrate on Ligand Interaction with the Human Multidrug
Downloaded from molpharm.aspetjournals.org at ASPET Journals on September 23, 2021 page 1 nd Interaction with the Human Multidrug Multidrug Human the with nd Interaction This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. -
Microclimatic Influences on Grape Quality
AusdemInstitutfürWeinanalytikundGetränkeforschung derHochschuleGeisenheimUniversity Prof.Dr.HelmutDietrich unddem InstitutfürPŇanzenbauundPŇanzenzüchtungII derJustusͲLiebigͲUniversitätGießen ProfessurfürBiometrieundPopulationsgenetik Prof.Dr.MatthiasFrisch Microclimaticinfluencesongrapequality Dissertation zurErlangungdesGradeseinesDoktors derAgrarwissenschaften imFachbereich Agrarwissenschaften,OekotrophologieundUmweltmanagement JustusͲLiebigͲUniversitätGießen Vorgelegtvon MatthiasFriedelausAlzenau Gießen,31.03.2017 Selbständigkeitserklärung Icherkläre:IchhabedievorgelegteDissertationselbständigundohneunerlaubte fremde Hilfe und nur mit den Hilfen angefertigt, die ich in der Dissertation angegebenhabe.AlleTextstellen,diewörtlichodersinngemäßausveröffentlichten Schriften entnommen sind, und alle Angaben, die auf mündlichen Auskünften beruhen,sindalssolchekenntlichgemacht.Beidenvonmirdurchgeführtenundin der Dissertation erwähnten Untersuchungen habe ich die Grundsätze guter wissenschaftlicher Praxis, wie sie in der „Satzung der JustusͲLiebigͲUniversität Gießen zur Sicherung guter wissenschaftlicher Praxis“ niedergelegt sind, eingehalten. Declarationofauthorship Ideclare: thisdissertationsubmittedisaworkof myown,writtenwithoutany illegitimate help by any third party and only with materials indicated in the dissertation. I have indicated in the text where I have used text from already publishedsources,eitherwordforwordorinsubstance,andwhereIhavemade statements based on oral information given to me. At any time during the investigationscarriedoutbymeanddescribedinthedissertation,Ifollowedthe -
TECHNISCHE UNIVERSITÄT MÜNCHEN Large Scale
TECHNISCHE UNIVERSITÄT MÜNCHEN Lehrstuhl für Genomorientierte Bioinformatik Large Scale Knowledge Extraction from Biomedical Literature Based on Semantic Role Labeling Thorsten Barnickel Vollständiger Abdruck der von der Fakultät Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt der Technischen Universität München zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften genehmigten Dissertation. Vorsitzende: Univ.‐Prof. Dr. I. Antes Prüfer der Dissertation: 1. Univ.‐Prof. Dr. H.‐W. Mewes 2. Univ.‐Prof. Dr. R. Zimmer (Ludwig‐Maximilians‐Universität München) Die Dissertation wurde am 30. Juli bei der Technischen Universität München eingereicht und durch die Fakultät Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt am 25. November 2009 angenommen. ACKNOWLEDGEMENTS First and foremost, I would like to express my deep gratitude to my promoter Dr. Volker Stümpflen. Without his continuing, stimulating encouragement and his excellent background in Enterprise technologies still being predominantly used in the IT-industry rather than in academic research, I would not have been able to finish my doctorate in the presented form. Facing the tremendous amount of data that was generated by gathering the positional information of millions of biomedical terms, I was close to cutting the project down to a notably smaller version compared to the text mining system presented in this thesis. Volkers knowledge on database servers and performance tuning significantly contributed to the development of a database schema finally being able to cope with the immense amount of data. I would also like to cordially thank Prof. Dr. Hans-Werner Mewes, head of the Institute for Bioinformatics and Systems Biology (IBIS), for giving me the opportunity to do my doctorate at his institute and for his friendly support and encouragement all along my time at IBIS. -
The Cyanogenic Polymorphism in Trifolium Repens L
Heredity66 (1991) 105—115 Received 16 May 1990 Genetical Society of Great Britain The cyanogenic polymorphism in Trifolium repens L. (white clover) M. A. HUGHES Department of Biochemistry and Genetics, The Medical School, The University, Newcastle upon Tyne NE2 4HH Thecyanogenic polymorphism in white clover is controlled by alleles of two independently segregating loci. Biochemical studies have shown that non-functional alleles of the Ac locus, which controls the level of cyanoglucoside produced in leaf tissue, result in the loss of several steps in the biosynthetic pathway. Alleles of the Li locus control the synthesis of the hydrolytic enzyme, linamarase, which is responsible for HCN release following tissue damage. Studies on the selective forces and the distribution of the cyanogenic morphs of white clover are discussed in relation to the quantitative variation in cyanogenesis revealed by biochemical studies. Molecular studies reveal considerable restriction fragment length polymorphism for linamarase homologous genes. Keywords:cyanogenesis,polymorphism, Trifolium repen, white clover. genetics to plant taxomony. This review discusses the Introduction extensive and diverse ecological genetic studies in rela- Theterm cyanogenesis describes the release of hydro- tion to the more recent biochemical and molecular cyanic acid (HCN), which occurs when the tissues of studies of cyanogenesis in white clover. some plant species are damaged. The first report of cyanogenesis in Trifolium repens (white clover) was by Mirande (1912) and this was shortly followed by a Biochemistry paper which demonstrated that the species was poly- Theproduction of HCN by higher plants depends morphic for the character, with both cyanogenic and upon the co-occurrence of a cyanogenic glycoside and acyanogenic plants occurring in the same population catabolic enzymes. -
Frontespizio Tesi Per Commissari
To my sister II II Table of Contents TABLE OF CONTENTS ABSTRACT I INTRODUCTION Introduction 3 Aim 4 Selected matrices 5 General conclusions 6 CHAPTER I AGRICULTURAL RESIDUES AS A SOURCE OF BIOACTIVE NATURAL PRODUCTS 1.1. Introduction 9 1.2. Agricultural residues 10 1.3. Valorisation processes 10 1.4. Recovery of bioactive natural products 12 1.5. Bioactive compounds from vegetable and fruit by-products 13 1.6. Remarks on the use of by-products and future prospects 16 1.7. Food waste valorisation: winery waste and by-products 18 CHAPTER II TECHNIQUES FOR ANALYSIS OF BIOACTIVE COMPOUNDS 2.1. Extraction 23 2.1.1. PLE 25 2.1.2. SFE 27 2.1.3. UAE 28 2.2. Analytical techniques 28 EXPERIMENTAL PART Table of Contents CHAPTER III SECTION A CHEMICAL PROFILE AND CELLULAR ANTIOXIDANT ACTIVITY OF ARTICHOKE BY-PRODUCTS 3A 1. Introduction 35 3A 2. Results and discussion 36 3A 2.1. Phenolic profile of artichoke by-products by UHPLC-DAD- 36 HRMS n 3A 2.2. Quantitative profile of artichoke by-products 41 3A 2.3. Inulin content of artichoke by-products 46 3A 2.4. Cellular antioxidant activity (CAA) of artichoke by- 46 products 3A 3. Conclusions 50 3A 4. Materials and methods 50 3A 4.1. Materials 50 3A 4.2. Artichoke by-product samples 51 3A 4.3. Phenolic compounds extraction 52 3A 4.4. UHPLC-DAD-HRMS n analysis 52 3A 4.5. Quantitative analysis by UHPLC-UV 53 3A 4.6. Determination of inulin 55 3A 4.7. Cell cultures, treatments and viability assay 56 3A 4.8. -
Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites
nutrients Review Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites Matej Sova 1,* and Luciano Saso 2 1 Faculty of Pharmacy, University of Ljubljana, Aškerˇceva7, 1000 Ljubljana, Slovenia 2 Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy; [email protected] * Correspondence: matej.sova@ffa.uni-lj.si; Tel.: +386-1-476-9556 Received: 24 June 2020; Accepted: 22 July 2020; Published: 23 July 2020 Abstract: Hydroxycinnamic acids (HCAs) are important natural phenolic compounds present in high concentrations in fruits, vegetables, cereals, coffee, tea and wine. Many health beneficial effects have been acknowledged in food products rich in HCAs; however, food processing, dietary intake, bioaccessibility and pharmacokinetics have a high impact on HCAs to reach the target tissue in order to exert their biological activities. In particular, metabolism is of high importance since HCAs’ metabolites could either lose the activity or be even more potent compared to the parent compounds. In this review, natural sources and pharmacokinetic properties of HCAs and their esters are presented and discussed. The main focus is on their metabolism along with biological activities and health benefits. Special emphasis is given on specific effects of HCAs’ metabolites in comparison with their parent compounds. Keywords: diet; natural compounds; phenolic acids; hydroxycinnamic acids; metabolites; pharmacokinetic properties; biological activities; health effects 1. Introduction Our diet rich in plant food contains several health-beneficial ingredients. Among such ingredients, polyphenols represent one of the most important natural compounds. Phenolic compounds are members of probably the largest group of plant secondary metabolites and have the main function to protect the plants against ultraviolet radiation or invasion by pathogens [1,2]. -
Taxifolin: a Wonder Molecule in Making Multiple Drug Targets
Short Communication Annals of Pharmacology and Pharmaceutics Published: 22 Aug, 2017 Taxifolin: A Wonder Molecule in Making Multiple Drug Targets Utkarsh Raj, Imlimaong Aier and Pritish Kumar Varadwaj* Department of Bioinformatics and Applied Sciences, Indian Institute of Information Technology, Allahabad, India Keywords Taxifolin; Anti-cancerous; Anti-ebola; Anti-oxidant; Anti-inflammatory Short Communication Taxifolin (often referred to as dihydroquercetin) is a flavanonol which is a part of the phytonutrient family (a set of chemical materials that occur evidently in flora and have more than one fitness benefits however aren't taken into consideration vital to human fitness). Taxifolin has been observed in a variety of cone bearing gymnosperms, like, Pinus roxburghii [1], Cedrus deodara [1], Larix sibirica (the Russian or Siberian larch) and inside the Chinese yew, Taxus chinensis var. mairei [2]. Its presence has also been reported in silymarin extract from the milk thistle seeds and cherry wood aged vinegar [3]. The 2D structure of Taxifolin has been depicted in Figure1. Over the past 50 years, almost six hundred studies (mostly conducted in Russia) have investigated the efficacy and protection of taxifolin. The important roles of the compound Taxifolin has been elucidated in Figure 2. The main highlights of this compound are its antioxidant efficiency and vascular-defensive movement. Taxifolin has also been shown to provide benefits to cardiovascular health, the pores and skin, cognitive feature, contamination, allergic reactions and immunodeficiency, in addition to the fitness of diabetics. Amongst others, research has examined that taxifolin is a brilliant antioxidant, far more effective than dietary carotenoids and it lowers blood viscosity and improves capillary microcirculation. -
Compendium of Botanicals Reported to Contain Naturally Occuring Substances of Possible Concern for Human Health When Used in Food and Food Supplements
View metadata,Downloaded citation and from similar orbit.dtu.dk papers on:at core.ac.uk Dec 20, 2017 brought to you by CORE provided by Online Research Database In Technology Compendium of botanicals reported to contain naturally occuring substances of possible concern for human health when used in food and food supplements EFSA authors; Pilegaard, Kirsten Link to article, DOI: 10.2903/j.efsa.2012.2663 Publication date: 2012 Document Version Publisher's PDF, also known as Version of record Link back to DTU Orbit Citation (APA): EFSA authors (2012). Compendium of botanicals reported to contain naturally occuring substances of possible concern for human health when used in food and food supplements. Parma, Italy: Europen Food Safety Authority. (The EFSA Journal; No. 2663, Vol. 10(5)). DOI: 10.2903/j.efsa.2012.2663 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. EFSA Journal 2012;10(5):2663 SCIENTIFIC REPORT OF EFSA Compendium of botanicals reported to contain naturally occuring substances of possible concern for human health when used in food and food supplements1 European Food Safety Authority2, 3 European Food Safety Authority (EFSA), Parma, Italy ABSTRACT In April 2009, EFSA published on its website a Compendium of botanicals reported to contain toxic, addictive, psychotropic or other substances of concern. -
Journal of the Hellenic Veterinary Medical Society
Journal of the Hellenic Veterinary Medical Society Vol. 71, 2020 Isobolographic analysis of analgesic interactions of silymarin with ketamine in mice NASER A.S. Department of physiology, biochemistry and pharmacology, Faculty of Veterinary Medicine, University of Mosul, Mosul, Iraq ALBADRANY Y. Department of physiology, biochemistry and pharmacology, Faculty of Veterinary Medicine, University of Mosul, Mosul, Iraq SHAABAN K.A. [email protected] https://doi.org/10.12681/jhvms.23653 Copyright © 2020 A.S. NASER, Y. ALBADRANY, K.A. SHAABAN To cite this article: NASER, A.S., ALBADRANY, Y., & SHAABAN, K.A. (2020). Isobolographic analysis of analgesic interactions of silymarin with ketamine in mice. Journal of the Hellenic Veterinary Medical Society, 71(2), 2171-2178. doi:https://doi.org/10.12681/jhvms.23653 http://epublishing.ekt.gr | e-Publisher: EKT | Downloaded at 23/09/2021 18:43:31 | J HELLENIC VET MED SOC 2020, 71(2): 2171-2178 Research article ΠΕΚΕ 2020, 71(2): 2171-2178 Ερευνητικό άρθρο Isobolographic analysis of analgesic interactions of silymarin with ketamine in mice A.S. Naser1*, Y. Albadrany2, K.A. Shaaban2 1Department of physiology, biochemistry and pharmacology, Faculty of Veterinary Medicine, University of Mosul, Mosul, Iraq 2Department of physiology, biochemistry and pharmacology, Faculty of Veterinary Medicine, University of Mosul, Mosul, Iraq ABSTRACT: The present study was undertaken to explore the analgesic effect of silymarin and ketamine alone or in combination in mice. Analgesia was measured by using a hot plate and the writhing test. The up-and-down method was used to determine the median effective analgesic dosages (ED50s) of silymarin and ketamine administered intraper- itoneally (ip) either alone or together. -
Performance of a Protein Extracted from Potatoes for Fining of White Musts
Food Chemistry 190 (2016) 237–243 Contents lists available at ScienceDirect Food Chemistry journal homepage: www.elsevier.com/locate/foodchem Performance of a protein extracted from potatoes for fining of white musts ⇑ Angelita Gambuti a, Alessandra Rinaldi a,b, , Raffaele Romano c, Nadia Manzo c, Luigi Moio a a Dipartimento Agraria, Università degli Studi di Napoli Federico II, Sezione di Scienze della Vigna e del Vino, Viale Italia, 83100 Avellino, Italy b Biolaffort, 126 Quai de la Sauys, 33100 Bordeaux, France c Dipartimento Agraria, Università degli Studi di Napoli Federico II, via Università 100, 80055 Portici (NA), Italy article info abstract Article history: In this study, the potentiality of Patatin (P), a protein extracted from potato, as must fining agent was Received 4 March 2015 investigated on musts obtained from two South Italy grape cultivars (Falanghina and Greco). Besides P, Received in revised form 14 May 2015 fining agents as bentonite (B) and potassium caseinate (C) were assayed at different concentrations. Accepted 15 May 2015 The rate of sedimentation, the decline of turbidity during time, the absorbance at 420 nm, the GRP (grape Available online 16 May 2015 reaction products) and hydroxycinnamic acids (HCA) concentrations were determined. The comparative trials showed that P is a suitable fining agent to prevent browning and decrease haze Keywords: during must settling because its effect on grape phenolics, brown pigments and turbidity is comparable Must fining and/or better than that detected for C. Its use as single fining agent or in combination with B depends on Potato proteins Browning must characteristics. Fining agents Ó 2015 Published by Elsevier Ltd. -
Giới Thiệu Luận Án
Nghiên cứu thành phần hoá học của một số loài cây thuộc họ Betulaceae và họ Zingiberaceae Trương Thị Tố Chinh Trường Đại học Khoa học Tự nhiên Khoa Hóa học Chuyên ngành: Hóa Hữu cơ; Mã số: 62 44 27 01 Người hướng dẫn: 1. GS. TSKH. Phan Tống Sơn 2. PGS TS Phan Minh Giang Năm bảo vệ: 2011 Abstract. Đối tượng nghiên cứu của luận án là 4 loài cây thuộc họ Cáng lò và họ Gừng, là những cây thuộc loại hiếm hoặc mới chỉ được phát hiện gần đây và chưa được nghiên cứu về thành phần hoá học: Tống quán sủi (Alnus nepalensis D. Don), Cáng lò (Betula alnoides Buch. -Ham. ex D. Don), Gừng môi tím đốm (Zingiber peninsulare I. Theilade), Riềng maclurei (Alpinia maclurei Merr.). Kết quả nghiên cứu mới về một số loài thuộc họ Cáng lò và họ Gừng của Việt Nam như sau: Đã xây dựng được qui trình thích hợp để điều chế các phần chiết từ các mẫu của các loài cây được nghiên cứu và các điều kiện phân tách sắc ký để phân lập các hợp chất tinh khiết từ các phần chiết. Lần đầu tiên đã nghiên cứu về thành phần hoá học của cây Tống quán sủi (Alnus nepalensis D. Don) và phân lập được 21 hợp chất; cây Cáng lò (Betula alnoides Buch. -Ham. ex D. Don) và đã phân lập được 16 hợp chất cùng hai hỗn hợp, mỗi hỗn hợp gồm 2 hợp chất; cây Gừng môi tím đốm (Zingiber peninsulare I. -
Rapid Detection Method to Quantify Linamarin Content in Cassava Dinara S
essing oc & pr B o io i t B e Gunasekera et al, J Bioprocess Biotech 2018, 8:6 f c h o n l Journal of Bioprocessing & DOI: 10.4172/2155-9821.1000342 i a q n u r e u s o J Biotechniques ISSN: 2155-9821 Research Article Open Access Rapid Detection Method to Quantify Linamarin Content in Cassava Dinara S. Gunasekera*, Binu P. Senanayake, Ranga K. Dissanayake, M.A.M. Azrin, Dhanushi T. Welideniya, Anjana Delpe Acharige, K.A.U. Samanthi, W.M.U.K. Wanninayake, Madhavi de Silva, Achini Eliyapura, Veranja Karunaratne and G.A.J Amaratunga. Sri Lanka Institute of Nanotechnology, Homagama, Sri Lanka *Corresponding author: Dinara S Gunasekera, Senior Research Scientist, Sri Lanka Institute of Nanotechnology, Homagama, Sri Lanka, Tel: +94775448584; E-mail: [email protected] Received date: November 21, 2018; Accepted date: December 12, 2018; Published date: December 20, 2018 Copyright: © 2018 Gunasekera DS et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract There are a number of natural remedies against cancer. Cassava (Manihot esculenta Crantz) has been proven to be a natural remedy against cancer due to the cyanogenic compounds it contains such as linamarin. A rapid and simple liquid chromatography-mass spectroscopy (LC-MS) method was developed to identify and quantify linamarin in Cassava. The method was developed using various Cassava (Manihot esculenta Crantz) extracts. Developed application is not limited to Cassava, but can be extended to other types of linamarin containing plant materials as well.