DOCSLIB.ORG

Anti-Tumor Pharmacology

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Anti-Tumor Pharmacology 1078 Section 3: Anti-tumor pharmacology Doi: 10.1038/aps.2017.66 Wen-na SHI1, Shu-xiang CUI2, Zhi-yu SONG1, Shu-qing WANG1, Shi-yue SUN1, Xin-feng S3.1 YU1, Yu-hang ZHANG1, Zu-hua GAO3,*, Xian-jun QU1,* Synergistic effect of Astragalus flavonoids on breast cancer chemotherapeutic agent 1Department of Pharmacology, School of Basic Medical Sciences, Capital Medical cyclophosphamide based on the regulation of immune function University, Beijing, China; 2Beijing Key Laboratory of Environmental Toxicology, Jing WANG, Xiao LI, Yan-shuang QI, Jia-hui NIE, Xue-mei QIN* Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan Medical University, Beijing, China; 3Department of Pathology, McGill University, 030006, China Montreal, Quebec, Canada *To whom correspondence should be addressed. *To whom correspondence should be addressed. E-mail: [email protected] E-mail: [email protected] The present study aimed to observe the synergistic effect of Astragalus flavonoids The resistance mechanisms that limit the efficacy of retinoid therapy in cancer are (TFA) on breast cancer chemotherapeutic agent cyclophosphamide (CTX) and its poorly understood. Sphingosine kinase 2 (SphK2) is a highly conserved enzyme that effect on immunologic function. 4T1 breast cancer bearing mice were established is mainly located in the nucleus and endoplasmic reticulum. Unlike well-studied and then randomly into control group, model group, CTX group (80 mg/kg), sphingosine kinase 1 (SphK1) located in the cytosol, little has yet understood the CTX (80 mg/kg) combined with TFA (6 mg/kg) group and TFA group (6 mg/ functions of SphK2. Here we show that SphK2 over-expression contributes to the kg). After 3 weeks of different treatments, tumor inhibition rates were measured; resistance of all-trans retinoic acid (ATRA) therapy in colon cancer through rapid subpopulation of the splenic lymphocytes and marrow derived suppressor cells degradation of cytoplasmic retinoid X receptor α (RXRα) by lysine 48 (K48)- and (MDSCs) in circulating blood were detected by flow cytometry. Compared with lysine 63 (K63)-based polyubiquitination. Human colonic adenocarcinoma HCT- model group, both CTX and CTX-TFA can significantly inhibit tumor growth with 116 cells transfected with SphK2 (HCT-116Sphk2 cells) demonstrate resistance to inhibition rate of 55.61% (P<0.05) and 70.91% (P<0.01), respectively. However, ATRA therapy as determined by in vitro and in vivo assays. Sphk2 over-expression compared to CTX group, CTX-TFA group showed a higher inhibition rate increases the ATRA-induced nuclear RXRα export to cytoplasm and then rapidly (P<0.05). CTX-TFA group showed an increased percentage of splenic CD3+, CD4+ degrades RXRα through the poly-ubiquitination pathway. We further show that T and CD8+ T lymphocytes (P<0.05, P<0.01) and decreased percentage of MDSCs Sphk2 activates the ubiquitin-proteasome system through the signal mechanisms (CD11b+Ly6Chi) (P<0.05, P<0.01), whereas the percentage of CD19+ cells remained of (1) K48-linked proteosomal degradation and (2) K63-linked ubiquitin-dependent unchanged. TFA could enhance the anti-tumor effect of CTX and the synergistic autophagic degradation. These results provide new insights into the biological effect probably result from improving tumor immune-suppression via increasing functions of Sphk2 and the molecular mechanisms that underlie the Sphk2- the percentage of CD3+, CD4+ T and CD8+ T lymphocytes and down-regulating the mediated resistance to retinoid therapy. percentage of MDSCs. Keywords: sphingosine kinase 2 (SphK2); retinoid therapy resistance; cytoplasmic Keywords: Astragalus flavonoids; breast cancer; cyclophosphamide; immune RXRα; polyubiquitination; rapid degradation; lysine 48 (K48); lysine 63 (K63) function Acknowledgements: This work was supported by grants from National Natural Acknowledgements: This work was supported by grants from Science and Science Foundation of China (No 81373436, 81373435 and 91229113) and the Beijing Technology Innovation Team of Shanxi Province (No 201605D131045-18) and Science Foundation (No 7142017). We thank the Research Institute of the McGill Key laboratory of Effective Substances Research and Utilization in TCM of Shanxi University Health Centre for their financial support. province (No 201605D111004). S3.4 S3.2 Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid Anti-Warburg effect elicited by cAMP-PGC1α pathway drives differentiation of myricetin and its derivative in APCMin/+ mice glioblastoma cells into astrocytes Ye LI1, Shi-yue SUN1, Zhi-yu SONG1, Shu-qing WANG1, Zu-hua GAO2, Xian-jun QU1, Shu- Wen-bo ZHU1, Fan XING1, Jia-luo MAI1, Jia-yu GU1, Xin-cheng LIU1, Wan-jun LU1, Guang- xiang CUI3,* mei YAN1,* 1Department of Pharmacology, Capital Medical University School of Basic Medical 1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Sciences, Beijing, China; 2Department of Toxicology and Sanitary Chemistry, School Gangzhou 510080, China of Public Health, Capital Medical University, Beijing, China; 3Department of Pathology, *To whom correspondence should be addressed. McGill University, Montreal, Quebec, Canada E-mail: [email protected] *To whom correspondence should be addressed. Glioblastoma (GBM) is among the most aggressive of human cancers. Although E-mail: [email protected] differentiation therapy has been proposed as a potential approach to treat GBM, Myricetin is a natural dietary flavonoid compound. We evaluated the efficacy the mechanisms of induced differentiation remain poorly defined. Here, we of myricetin and its derivative against intestinal tumorigenesis in adenomatous established an induced differentiation model of GBM using cAMP activators, polyposis coli multiple intestinal neoplasia (APCMin/+) mice. Myricetin was given which specifically directed GBM into astroglia. Next, transcriptomic and proteomic orally once a day for 12 consecutive weeks. APCMin/+ mice fed with myricetin analyses uncovered oxidative phosphorylation and mitochondrial biogenesis were developed fewer and smaller polyps without any adverse effects. Histopathological involved in induced differentiation of GBM. Further investigation showed dbcAMP analysis showed a decreased number of dysplastic cells and degree of dysplasia reversed the Warburg effect evidenced by increase in oxygen consumption and in each polyp. Immunohistochemical and Western blot analysis revealed reduction of lactate production. Stimulated mitochondrial biogenesis downstream that myricetin selectively inhibits cell proliferation and induces apoptosis in of CREB/PGC1α pathway triggered metabolic shift and differentiation. Blocking adenomatous polyps. The effects of myricetin were associated with a modulation mitochondrial biogenesis by mdivi1 or silencing PGC1α abrogated differentiation, the GSK-3β and Wnt/β-catenin pathways. ELISA analysis showed a reduced reversely overexpression of PGC1α elicited differentiation. In GBM xenograft concentration of pro-inflammatory cytokines IL-1β, IL-6, TNF-α, and PGE2 in the models and patient-derived GBM samples, cAMP activators also induced tumor adenomatous polyps and blood, which were elevated in APCMin/+ mice. The effect of growth inhibition and differentiation. This study shows mitochondrial biogenesis myricetin treatment was most prominent in the adenomatous polyps originating in and metabolic switch to oxidative phosphorylation drive the differentiation process the colon. Further study showed that myricetin down-regulates the phosphorylated of tumor cells. p38 MAPK/Akt/mTOR signaling pathways, which may be the mechanisms for Keywords: differentiation therapy; metabolic reprogramming; Warburg effect; PGC- the inhibition of adenomatous polyps by myricetin. Taken together, our data 1 alpha; mitochondrial biogenesis show that myricetin inhibits intestinal tumorigenesis through a collection of Acknowledgements: This work was supported by grants from the the National biological activities. Given these results, we suggest that myricetin could be used Natural Science Foundation of China (No 81673447), the Natural Science preventatively to reduce the risk of developing colon cancers. Foundation of Guangdong Province, China (No 2014A030313156) and the specific Keywords: myricetin; APCMin/+ mouse model; intestinal adenomatous polyps; project of science and technology of Guangzhou (No 201607010396). Wnt/β-catenin pathway; chronic inflammation; p38 MAPK/Akt/mTOR signaling pathways S3.3 Acknowledgements: This work was supported by grants from the National Natural Over-expression of SphK2 contributes to ATRA resistance in colon cancer through Science Foundation of China (No 81373435). rapid degradation of cytoplasmic RXRα by K48/K63-linked polyubiquitination Acta Pharmacologica Sinica (2017) Section 3: Anti-tumor pharmacology 1079 S3.5 Development Plan of Shandong Province, China (No 2014WS0486). The application of "Warburg effect" in chemosensitization–a case report Yong-ping LIU*, Ya-ping ZHANG, Xi-bao MAO, Qiu-feng QI, Ming ZHU, Yang LING S3.7 Department of Oncology Medicine, Changzhou Tumor Hospital Affiliated to Soochou Quantitative proteomics of transgenic prostate cancer mice reveals that PDGF-B University, Honghe Road No.68, Xinbei Area, Changzhou 213002, China regulatory network plays a key role in prostate cancer progression *To whom correspondence should be addressed. Dan WANG, Jia MI, Chun-hua YANG, Shu-ping ZHANG, Bin WANG,
Load more

Recommended publications
  • Environmental Impact Assessment Report
    Environmental Impact Assessment Report For Public Disclosure Authorized Changzhi Sustainable Urban Transport Project E2858 v3 Public Disclosure Authorized Public Disclosure Authorized Shanxi Academy of Environmental Sciences Sept, 2011 Public Disclosure Authorized I TABLE OF CONTENT 1. GENERAL ................................................................ ................................ 1.1 P ROJECT BACKGROUND ..............................................................................................1 1.2 B ASIS FOR ASSESSMENT ..............................................................................................2 1.3 P URPOSE OF ASSESSMENT AND GUIDELINES .................................................................4 1.4 P ROJECT CLASSIFICATION ...........................................................................................5 1.5 A SSESSMENT CLASS AND COVERAGE ..........................................................................6 1.6 I DENTIFICATION OF MAJOR ENVIRONMENTAL ISSUE AND ENVIRONMENTAL FACTORS ......8 1.7 A SSESSMENT FOCUS ...................................................................................................1 1.8 A PPLICABLE ASSESSMENT STANDARD ..........................................................................1 1.9 P OLLUTION CONTROL AND ENVIRONMENTAL PROTECTION TARGETS .............................5 2. ENVIRONMENTAL BASELINE ................................ ................................ 2.1 N ATURAL ENVIRONMENT ............................................................................................3
    [Show full text]
  • Shanxi University Prospectus
    Shanxi University Prospectus Application Information for International Students Contact Information Website: www.sxu.edu.cn; http://siee.sxu.edu.cn/ Degree Program: Tel: +86-351-7210633 or 7550956 Email: [email protected] Non-Degree Program: Tel: +86-351-7018987 Email: [email protected] Address: School of International Education and Exchange, Shanxi University; No.92, Wucheng Rd., 2019 Entry Taiyuan, Shanxi, 030006, P.R. China Welcome to Shanxi University Table of Contents Welcome to Shanxi University Destination China hanxi University is widely recognized for its research, development 1. Shanxi Province and innovation. Joining the University as a student provides you 2. The City of Taiyuan Swith a truly unique opportunity to enhance your Chinese language proficiency, and work with some of the most influential academics in your Introduction of Shanxi University chosen field. In the University you will develop your specialist skills, deepen your understanding of Chinese culture, and gain new perspectives 3. Our Faculty for your future career. Whether your plans are for employment or further 4. International Exchanges study in China, or anywhere in the world, you will find the highest quality 5. Campus Security research and learning opportunities here. 6. Life in Shanxi University 7. Flexible Admission Join us, explore a comprehensive range of programs; enjoy the first-class education as part of diversified global community. Study at Shanxi University Shanxi University sincerely and warmly welcomes you! 8. Application for International Students 9. Majors for International Students 10. Scholarships 11. Registration Period 12. Accommodation Condition 13. Medical Insurance 14. Visa Information hanxi province, with a history of more than 5000 years, is the cradle of the splendid Chinese civilizations, boasting its magnificent S mountains and rivers, abundant in natural resources, profound culture and diligent people.
    [Show full text]
  • Jinshang Bank Co., Ltd.* 晉商銀行股份有限公司 *
    Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement. JINSHANG BANK CO., LTD.* 晉商銀行股份有限公司* (A joint stock company incorporated in the People’s Republic of China with limited liability) (Stock Code: 2558) PROPOSED APPOINTMENT OF EXECUTIVE DIRECTOR The board (the “Board”) of directors (the “Director(s)”) of Jinshang Bank Co., Ltd.* (the “Bank”) is pleased to announce that: On January 17, 2020, the Board considered and approved the proposed appointment of Mr. Wang Junbiao (“Mr. Wang”) as an executive Director of the Bank. Such appointment is subject to the approval by the shareholders of the Bank at a general meeting. The biographical details of Mr. Wang are as follows: Wang Junbiao, aged 49, has more than 25 years of banking experience and has been elected as the deputy at the Thirteenth National People’s Congress since January 2018. Since January 2020, he has been serving as the secretary to the party committee of the Bank. Mr. Wang served as the secretary to the party committee and chairman of the board of directors of Shanxi State-owned Capital Investment and Operation Co., Ltd. (山西省國有資本投資運營有限公司) from July 2017 to December 2019; vice chairman of the board of directors, deputy secretary to the party committee and general manager of Shanxi Financial Investment Holding Group Co., Ltd.
    [Show full text]
  • Shijing and Han Yuefu
    SONGS THAT TOUCH OUR SOUL A COMPARATIVE STUDY OF FOLK SONGS IN TWO CHINESE CLASSICS: SHIJING AND HAN YUEFU by Yumei Wang A thesis submitted in conformity with the requirements for the degree of Master of Art Graduate Department of the East Asian Studies University of Toronto © Yumei Wang 2012 SONGS THAT TOUCH OUR SOUL A COMPARATIVE STUDY OF FOLK SONGS IN TWO CHINESE CLASSICS: SHIJING AND HAN YUEFU Yumei Wang Master of Art Graduate Department of the East Asian Studies University of Toronto 2012 Abstract The subject of my thesis is the comparative study of classical Chinese folk songs. Based on Jeffrey Wainwright, George Lansing Raymond, and Liu Xie’s theories, this study was conducted from four perspectives: theme, content, prosody structure and aesthetic features. The purposes of my thesis are to trace the originality of 160 folk songs in Shijing and 47 folk songs in Han yuefu , to illuminate the origin of Chinese folk songs and to demonstrate the secularism reflected in Chinese folk songs. My research makes contribution to the following four areas: it explores the relation between folk songs in Shijing and Han yuefu and compares the similarities and differences between them ; it reveals the poetic kinship between Shijing and Han yuefu; it evaluates the significance of the common people’s compositions; and it displays the unique artistic value and cultural influence of Chinese early folk songs. ii Acknowledgments I would like to express my sincere gratitude to my supervisor Professor Graham Sanders for his supervision, inspirations, and encouragements during my two years M.A study in the Department of East Asian Studies at University of Toronto.
    [Show full text]
  • Exploring Spatial Influence of Remotely Sensed PM2.5
    International Journal of Environmental Research and Public Health Article Exploring Spatial Influence of Remotely Sensed PM2.5 Concentration Using a Developed Deep Convolutional Neural Network Model Junming Li 1, Meijun Jin 2,* and Honglin Li 3 1 School of Statistics, Shanxi University of Finance and Economics, Wucheng Road 696, Taiyuan 030006, China; [email protected] or [email protected] 2 College of Architecture and Civil Engineering, Taiyuan University of Technology, Yingze Street 79, Taiyuan 030024, China 3 Shanxi Centre of Remote Sensing, 136 Street Yingze, Taiyuan 030001, China; [email protected] * Correspondence: [email protected] Received: 2 January 2019; Accepted: 31 January 2019; Published: 4 February 2019 Abstract: Currently, more and more remotely sensed data are being accumulated, and the spatial analysis methods for remotely sensed data, especially big data, are desiderating innovation. A deep convolutional network (CNN) model is proposed in this paper for exploiting the spatial influence feature in remotely sensed data. The method was applied in investigating the magnitude of the spatial influence of four factors—population, gross domestic product (GDP), terrain, land-use and land-cover (LULC)—on remotely sensed PM2.5 concentration over China. Satisfactory results were produced by the method. It demonstrates that the deep CNN model can be well applied in the field of spatial analysing remotely sensed big data. And the accuracy of the deep CNN is much higher than of geographically weighted regression (GWR) based on comparation. The results showed that population spatial density, GDP spatial density, terrain, and LULC could together determine the spatial distribution of PM2.5 annual concentrations with an overall spatial influencing magnitude of 97.85%.
    [Show full text]
  • Admission Plan for Students from Twinning Partners of Shanxi Province
    Admission Plan for Students from Twinning Partners of Shanxi Province School / Contact Major Reduction & Exemption Reduction/Exemption Conditions I Non-degree Programme Shanxi University accommodation fee / living (Ms. Han Haihong / Chinese http://siee.sxu.edu.cn/ allowance 0086-15034124670) Taiyuan University of Technology http://is.tyut.edu.cn/ tuition http://is.tyut.edu.cn/ (Mr. Wang Yi / 0086-13593169636) Shanxi University of Finance and Economics http://gjjyxy.sxufe.edu.cn/lxsc/zs Chinese (Mr.Wang Zefeng zy.htm /0086-15934152017) Shanxi Normal University HSK Level 3 (Chinese Need to meed admission tuition /accommodation fee (Ms. Guo Xibian/0086-15135711155) Proficiency Test) requirements .please refer to the 1 application information . http://wsc.sxnu.edu.cn/info/1017/ 1937.htm Practitioners of traditional Shanxi University of Chinese Acupuncture and Chinese medicine or acupuncture Medicine tuition massage and massage (Ms. Zhao Xueli/0086-15034018097) http://gjzx.sxtcm.edu.cn/ College scholarship is granted in Business College of Shanxi accordance with applicants' Chinese Language and University tuition /college scholarship performance. Culture Program (Ms. Zheng Nan /0086-15834106906) https://sites.google.com/view/bcs u/home Shanxi Institute of Mechanical tuition /accommodation Foreign students are required to Chinese &Electrical Engineering fee/scholarship (RMB800 yuan meet the course assessment for 2 (Ms. Li Jiong /0086-15536120009) per month ) the scholarship . http://english.sxjdxy.org/ II Undergraduate Programme Applicants are required to pass HSK Level 4 (over 200 points ) All majors excluding tuition/ accommodation fee/living Shanxi University and attend interview . Chinese Language allowance Please refer to the application information . Students applying for tuition reduction and exemption should Taiyuan University of Please refer to the have over 80 points of average tuition / living allowance (part) Technology application information academic scores in high school , and living allowance varies from A to D according to the 3 assessment .
    [Show full text]
  • Yanxi Pei Professor, Shanxi Unversity, China ORCID ID: 0000-0002-8428-3399
    Yanxi Pei Professor, Shanxi Unversity, China ORCID ID: 0000-0002-8428-3399 PERSONAL INFORMATION Date of Birth: Feb. 20, 1970 Gender: male Place of Birth: Shanxi, China Nationality: P. R. China ADDRESS School of Life Science, Shanxi University Wucheng Road 92#, Taiyuan, Shanxi, 030006, China COMMUNICATION Tel: 86-351-701-8161 (O), 86-139-3455-9401 (cell phone) Email address: [email protected]; EDUCATION PhD. 9/1999-7/2002 Institute of biotechnology, Zhejiang University,China Master. 9/1993-7/1996 College of horticulture, Shanxi Agricultural University, China Bachelor. 9/1989-7/1993 College of horticulture, Shanxi Agricultural University, China EXPERIENCE Professor: Shanxi University, 2007, 9- Present Visiting scholar, Cardiovascular & Metabolic Research Unit, lakehead university, Canada；2009.12-2010.6 Postdoctoral Research Fellow: Institute of Genetics and Development Biology, Chinese Academy of Sciences, China, 2004, 12-2008, 3 Associate Professor: Shanxi University, 2004, 9-2007, 9 Lecturer Position: Shanxi University, 1999, 9-2004, 9 ONGOING PROFESSIONAL ACTIVITIES Vice Dean, School of Life Science, Shanxi University, 2008, 10- Present GRANTS (as project manager)： 1 Mechnism of Ca2+ on gasotransmitter H2S to enhance the tolerance of heavy metal chromium（Cr6+） stress in Setaria italica，(National Natural Science Foundation of China (NSFC), 31671605), 2017.1-2020.12 2 The regulation and application of H2S in crucifer flowering (Research Project Supported by Shanxi Scholarship Council of China, 2016-008), 2016.6.15-2019.6.30 3 Project of Science and technology consulting in enterprise. Productivity Promotion Center of Taiyuan. 2015.8-2016.8 4 Development of new germplasm of controllable flower chrysanthemum and its supporting production technology (Scientific and technological project of Shanxi province, 20150311011-3), 2015.1-2017.12 5 The Influence of Protein Arginine Methylation on the Flowering Time Regulation by the Gasotransmitter H2S in Chinese Cabbage.
    [Show full text]
  • High-Performance Cavity-Enhanced Quantum Memory with Warm Atomic Cell
    High-performance cavity-enhanced quantum memory with warm atomic cell Lixia Ma Shanxi University Xing Lei Shanxi University Jieli Yan Shanxi University Ruiyang Li Shanxi University Ting Chai Shanxi University Zhihui Yan Shanxi University https://orcid.org/0000-0002-7149-4939 Xiaojun Jia ( [email protected] ) Shanxi University https://orcid.org/0000-0001-5499-5427 Changde Xie Shanxi University Kunchi Peng Shanxi University Article Keywords: quantum information technology, optics, magnetometry Posted Date: June 21st, 2021 DOI: https://doi.org/10.21203/rs.3.rs-568098/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License 1 High-performance cavity-enhanced quantum memory with warm atomic cell Lixia Ma1,3, Xing Lei1,3, Jieli Yan1, Ruiyang Li1, Ting Chai1, Zhihui Yan1,2∗, Xiaojun Jia1,2†, Changde Xie1,2 & Kunchi Peng1,2 1State Key Laboratory of Quantum Optics Quantum Optics Devices, Institute of Opto-Electronics, Shanxi University, Taiyuan 030006, P. R. China 2Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, P. R. China 3These authors contributed equally: Lixia Ma, Xing Lei. ∗e-mail:[email protected] †e-mail:[email protected] High-performance quantum memory for quantized states of light is a prerequisite build- ing block of quantum information technology. Despite great progresses of optical quantum memories based on interactions of light and atoms, physical features of these memories still can not satisfy the requirement for applications in practical quantum information systems, since all of them suffer from trade off between memory efficiency and excess noise. Here, we report a high-performance cavity-enhanced electromagnetically-induced-transparency memory with warm atomic cell in which a scheme of optimizing the spatial and tempo- ral modes based on the time-reversal approach is applied.
    [Show full text]
  • Pastor Hsi's Legacy
    Pastor Hsi’s Legacy 97 Chapter 6 Pastor Hsi’s Legacy A Local Christian Community in South Shanxi Yi Liu One hundred years after the Boxer Movement of 1900, the churches in Linfen of Shanxi Province attracted the attention of the Christian world again.1 While 100 years ago, the local Christians were seen as agents of foreign missionaries and even imperialism, one reason of the current conflict is because of their connection with a counter-China association based in US – the China Aid. When the missionaries interpreted their work is to liberate the locals from superstitions and backwardness, this new association claims that they come to “aid” the people both materially and spiritually. However, whether liberation or aid, the outcome is the tragedy focusing on the local Christians. While the outsiders who also sacrificed or suffered, they also won their reputation in the global world; but for the local Christians, they suffer just as suffering. From the foundation of the People’s Republic of China to the Reform and Opening Up under Mr. Deng Xiaoping, Shanxi is a relatively neglected place, economically, politically and culturally. When the people are impressed by the corrupted coal mine owners, they nearly forget it used to be a historical and civilizational place for thousand years, since the Neolithic age to the Jin State during the Spring and Autumn as well as the Warring States periods, and to the founders of the great Tang Dynasty, as well as the bankers in Ming and Qing. From a religious perspective, Shanxi also has a lower performance, though it had a rich resource of Buddhism and Taoism, such as the Yungang cave sculp- tures, the Wutai Mountain, the temple of General Guan (Guan Gong) and Lü * This research is supported by the project of China’s National Foundation for Social Sciences: “Global Pentecostalism and Christianity in Contemporary China” (11CZJ009).
    [Show full text]
  • Study on Atmospheric Environmental Problems and Countermeasures in Shanxi Province
    2019 3rd International Conference on Economics, Management Engineering and Education Technology (ICEMEET 2019) Study on Atmospheric Environmental Problems and Countermeasures in Shanxi Province Wang Yaqin 1,*, Ding Jiawen 2 1Faculty of Economics, Shanxi University of Finance and Economics, Taiyuan City, Shanxi Province, 030006 2School of Accounting, Shanxi University of Finance and Economics, Taiyuan City, Shanxi Province, 030006) *Email: [email protected] Keywords: atmospheric environment; problems; countermeasures; Shanxi Abstract: The Nineteenth National Congress emphasized the concept of "winning the battle of defending the blue sky". The outstanding atmospheric environmental problems in Shanxi Province seriously restrict the construction process of beautiful Shanxi Province and affect the construction of ecological civilization in China. In view of this, this paper studies and analyses the existing atmospheric environmental problems in Shanxi Province and the causes of the atmospheric environmental problems combs the impact of atmospheric environmental problems on nature, society, and human beings. We combines with the development of Shanxi Province itself, from strengthening propaganda, establishing and perfecting relevant environmental laws and regulations, strictly implementing the proposed measures and norms for the prevention and control of atmospheric pollution, developing circular economy, controlling gas emission sources and dust production sources, intensifying afforestation and other aspects to put forward countermeasures
    [Show full text]
  • 8Th IWACP Participants
    Hosted by Guangdong University of Technology, Beijing Normal University, Hainan Tropical Ocean University Organized by Co-organized by Paulista University, Dongguan University of Technology, Parthenope University, University of Sheffield, Deakin University in participation with 2 8th International Workshop | Advances in Cleaner Production Technical Report Responsible for the information: Biagio F. Giannetti (Conference Chair) http://www.advancesincleanerproduction.net COUPLING GREEN AND BLUE ECONOMIES: HOW ARE CLEANER PRODUCTION AND CITIES LEADING THE NEXT SUSTAINABLE DEVELOPMENT? Sanya, China November 13th to 15th - 2019 th 3 8 International Workshop | Advances in Cleaner Production The topic of the 8th International Workshop Advances in Cleaner Production (IWACP): Coupling green and Blue Economies: How are Cleaner Production and Cities Leading the Next Sustainable Development? was discussed by Brazilian and foreign researchers for three days in Sanya, China during the period of November 13th to 15th, 2019. The international conference was organized by the Postgraduate Program in Production Engineering (Master's and Doctoral Program) and Co-organized by Dongguan University of Technology, Parthenope University, University of Sheffield, Deakin University. The event counted with the partnership of the (University of Firenze, Italy), UNISON (Universidad de Sonora, México), the University of Manitoba (Canada), BNU (Beijing Normal University, China), the Journal of Cleaner Production, and the ACPN (Advances in Cleaner Production Network). The hosting institutions were the Guangdong University of Technology, Beijing Normal University, and Hainan Tropical Ocean University The partnership with the Journal of Cleaner Production (https://www.journals.elsevier.com/journal-of-cleaner-production/), that started during the 1st IWACP was maintained with the support of the Co-Editors in Chief: Prof.
    [Show full text]
  • United Nations Nations Uniesv "
    \j r-n. '•' -• ' a -"..,•- UNITED NATIONS NATIONS UNIESV " THE SECRETARY-GENERAL MESSAGE TO SHANXI UNIVERSITY ON THE OCCASION OF ITS 100TH ANNIVERSARY Shanvi. 8 Mav 2002 It gives me great pleasure to send my greetings to Shanxi University on the occasion of its centennial. Your distinguished institution has a diverse student body, a faculty with a broad range of expertise, productive ties with universities in many other countries, and a strong commitment to research and inquiry that includes an international perspective. Graduates of the University have gone on to become members of the diplomatic corps, and in this and other fields have helped to promote closer contacts and better understanding between China and the world at large. Education is a key element in development, social progress and human freedom. That is why, at the Millennium Summit at the United Nations in September 2000 - the largest-ever gathering of world leaders - it was decided that one of the "Millennium Development Goals" should be to ensure that every child receives primary education and to eliminate gender disparity in education at all levels. We must continue to do our utmost to ensure that in an era of globalization, knowledge, too, can be globalized and reach across nations. For 100 years, Shanxi University has contributed to this vital endeavour by enriching minds and preparing young people for the responsibilities they will take on as the next generation of leaders both in their own communities and in the international arena. It is my pleasure to congratulate you on this anniversary and milestone, and to thank you for your support of the United Nations.
    [Show full text]