nutrients Review Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications Alessandro Colletti 1, Luciano Sangiorgio 2, Alma Martelli 3,4,5 , Lara Testai 3,4,5 , Arrigo F. G. Cicero 6,7 and Giancarlo Cravotto 1,8,* 1 Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy;
[email protected] 2 Department of Pediatric Urology, SS. Antonio and Biagio and Cesare Arrigo Hospital, 15121 Alessandria, Italy;
[email protected] 3 Department of Pharmacy, University of Pisa, Via Bonanno 6, 56120 Pisa, Italy;
[email protected] (A.M.);
[email protected] (L.T.) 4 Interdepartmental Research Centre “Nutraceuticals and Food for Health (NUTRAFOOD)”, University of Pisa, 56120 Pisa, Italy 5 Interdepartmental Research Centre of Ageing, Biology and Pathology, University of Pisa, 56120 Pisa, Italy 6 Medical and Surgical Sciences Department, University of Bologna, 40138 Bologna, Italy;
[email protected] 7 IRCCS AOU S. Orsola-Malpighi, 40138 Bologna, Italy 8 World-Class Research Center “Digital Biodesign and Personalized Healthcare”, Sechenov First Moscow State Medical University, 119048 Moscow, Russia * Correspondence:
[email protected] Abstract: Cranberry is a fruit originally from New England and currently growing throughout the east and northeast parts of the USA and Canada. The supplementation of cranberry extracts as nutraceuticals showed to contribute to the prevention of urinary tract infections, and most likely Citation: Colletti, A.; Sangiorgio, L.; it may help to prevent cardiovascular and gastroenteric diseases, as highlighted by several clinical Martelli, A.; Testai, L.; Cicero, A.F.G.; trials. However, aiming to validate the efficacy and safety of clinical applications as long-term Cravotto, G.