2020 International Mock Board Exam Coalition

Total Page:16

File Type:pdf, Size:1020Kb

2020 International Mock Board Exam Coalition 2020 International Mock Board Exam Coalition Canada Queen University 03/12/2020 Kingston, Ontario Midwest (MI) University of Michigan 04/17/2020 Ann Arbor, MI Northeast (NY) Tri-Institutional Training Program 04/17/2020 New York, NY Midwest (MN) Mayo Clinic and University of Minnesota 04/18/2020 St. Paul, MN Pacific Northwest Oregon National Primate Research Center 04/18/2020 Beaverton, OR West Coast (Southern City of Hope/Beckman Research Institute 04/18/2020 CA) Duarte, CA Asia Singapore 04/25/2020 West Coast (Northern UC Davis 05/02/2020 CA) Davis, CA Midwest (WI) Wisconsin National Primate Research Center, 05/03/2020 Madison, WI Mid-Atlantic (MD) Fort Detrick 05/07/2020 Fort Detrick, MD Southeast (NC) NCSU Veterinary School 05/16/2020 Raleigh, NC Midwest (CO) Colorado State University 06/05/2020 Fort Collins, CO Southeast (GA) Yerkes National Primate Research Center 06/19/2020 Atlanta, GA Europe Bologna, Italy 06/26/2020 Mock ECLAM Exam Written Section – 230 Questions Referenced Answers – 102 Pages This examination is meant to be used as a study tool when preparing for the ACLAM or ECLAM Certifying Examinations. The material presented in this mock examination follows the ACLAM role delineation document, but is not necessarily reflective of the ACLAM or ECLAM Certifying Examinations. 1 2020 Exam Contributors Asia Bryan Emmett Ogden, DVM, DACLAM – Coordinator Mynn Michele Dy Varela, DVM Rex Malabanan Manguiat, DVM Jassia Pang, DVM, DACLAM Yasmina Arditi Paramastri, DVM, DACLAM Sharon Choy Heng Yee, BSc BVMS Canada Andrew Winterborn DVM, DACLAM - Coordinator Chereen Collymore DVM, DACLAM David Hanwell MSc DVM DVSc DACLAM Lise Phaneuf DVM, DVSc, DACLAM Janet Sunohara-Neilson, MSc, DVM, DVSc (LAS) Patricia Turner MS, DVM, DVSc, DACLAM, DABT, DECAWBM (WSEL) Europe Michael Wilkinson, DVM, CertLAS, PhD, DiplECLAM - Coordinator Sandra Barbosa, DVM, MSc, DiplECLAM Sergio Berdun, DVM, PhD, DiplECLAM Nikola Cesarovic, DrMedVet, PhD ETH, DiplECLAM, DiplSVLAS Gianfranco Di Caro, DVM, PhD Mid-Atlantic (Maryland) Patty Chen, DVM, DACLAM – Coordinator LTC Joe Royal, DVM, DACLAM – Coordinator Midwest (Colorado) Alexa Personett, DVM - Coordinator Jessica Ayers, DVM, DACLAM Mollie Burton, DVM, MS Joel Helbling, DVM Elizabeth Houston, DVM, MS Lon Kendall, DVM, PhD, DACLAM James Owiny, DVM, DACLAM Midwest (Michigan) Portia Allen, DVM, MS, DACLAM – Coordinator Patrick Lester DVM, MS, DACLAM – Coordinator Michael Bradley, DVM, DACLAM Zachary Freeman DVM, PHD, DACLAM Nicole Herndon, DVM, DACLAM Tara Martin, DVM, MS Catherine Si, DVM, MS Ania Skorupski, DVM Midwest (Minnesota) Jodi Scholz, DVM, DACLAM – Coordinator Nathan Koewler, DVM DACLAM - Coordinator Midwest (Wisconsin) Andres F. Mejia, DVM, MS, DACLAM, DACVP – Coordinator Rebekah Franklin, DVM, DACLAM – Coordinator 2 Bettina Gentry, DVM, PhD, DACLAM – Coordinator Melissa Berg, DVM Jessica Cayton, DVM Katie Chamber, DVM Jennifer Coonen, DVM, DACLAM Ryan C. Curtis, DVM, MS Greg Daggett, DVM, MLAS Ryan Dashek, DVM Casey Fitz, DVM Sammy Gerb, DVM Kevin Gustafson, DVM Michelle Harke, DVM Gabi Hofmann, DVM Emily Knebel, VMD Naomi Lee, DVM, MS Brigitte Raabe, DVM, DACLAM Heather Simmons, DVM, DACVP Saverio “Buddy” Capuano, DVM, DACLAM Lauren Wierenga, DVM Sarah Young, DVM Northeast (NY) Kathleen Ma, DVM - Coordinator Rachel Brownlee, DVM, DACLAM Amanda Carlson, DVM Christopher Cheleuitte-Nieves, PhD, DVM, DACLAM Leslie Lynn Diaz, DVM, MPH, DACLAM Catalina Echeverri, DVM Rebecca Floyd, DVM Mandy Kain, DVM, MSc Sean Kelly, VMD Kvin Lertpiriyapong, PhD, DVM, DACLAM Christine Lieggi, DVM, DACLAM Sara J. Mangosing, DVM, MSc Heather R. Martin, DVM Gerardo Mendoza, DVM Sébastien Monette, DMV, MVSc, DACVP Alessandra Piersigilli, DVM, PhD, DECVP Pacific Northwest Nicholas Reyes, DVM, MS, DACLAM – Coordinator Jennifer Sargent, DVM, MS, DACLAM – Coordinator Jeffrey Stanton, DVM, MA, DACLAM - Coordinator Sarah Alaniz, DVM Alan Avalos, DVM Jourdan Brune, DVM Tom Chatkupt, DVM John DenHerder, DVM Daniel Eldridge, DVM Christopher Gow, DVM Tiffany Lavinder, DVM Becky Lovasz, DVM Rhonda MacAllister, DVM Leandra Mosca DVM 3 Yogi Rajawat, DVM, PhD Kristin Zabrecky, DVM Southeast (GA) Sherrie Jean, DVM, DACLAM – Coordinator Southeast (NC) Victoria K. Baxter, DVM, PhD, DACLAM - Coordinator Steven Shipley, DVM, DACLAM – Coordinator Nicole Bacarella, MLAS, VMD Calvin Carpenter, DVM DACLAM Sheba Churchill, DVM, DACLAM Michelle Creamer-Hente, DVM, MS, DACLAM Greg Dugan, DVM Jenny Estes, DVM, MS Jeffrey Everitt, DVM, DACLAM, DACVP, FIATP Richard Fish, DVM, PhD, DACLAM Ilana Galex, DVM, MLAS Nneka George, DVM, DACLAM Virginia Godfrey, DVM, PhD, DACVP Tracy Heenan, DVM, CPIA Brendan Johnson, DVM Angela King-Herbert, DVM, DACLAM David M. Kurtz, DVM, PhD, DACLAM Chelsea D. Landon, DVM, PhD Charles Tyler Long, DVM, DACLAM, DABT, CPIA Gwendolyn McCormick, DVM, MS, DACLAM Marnie Metzler, DVM, PhD, DACLAM Erin Mitchell, DVM Stephanie Montgomery, DVM, PhD, DACVP Derek Norford, DVM, MS, PhD Tolu Olagbaju, DVM Karen Oppelt, DVM Adriel Otero Segui, DVM Nicolette Petervary, VMD, DACAW Allison R. Rogala, DVM, DACLAM Felicitas Smith, DVM, DACLAM Donna Webb-Wright, DVM Julia W. Whitaker, DVM, MS, DACLAM Chandra Williams, DVM, DACLAM Nayoung Yi, DVM, PhD Richard Young, DVM, DACLAM West Coast (Northern California) Rhonda Oates, DVM, MPVM, DACLAM - Coordinator Stephen Felt, DVM, DACLAM – Coordinator Brian Zude, DVM– Coordinator Alexandra Blaney, DVM Kelsey Elizabeth Carroll, DVM Dave Chu, DVM, DACLAM Allyson Kingsley Davis, DVM Kristopher G. Galang, DVM Alexandria Hicks-Nelson, DVM, MS Zoe Hsi, DVM 4 Kelly Jenson, DVM, DACLAM Erin Katz, DVM Kristina Lau, DVM, MLAS Betty Ma, DVM, DACLAM Andrea D. Moffitt, DVM, MLAS Kaela Lee Navarro, DVM, MS Samantha C. Puglisi, DVM Jacob H. Theil, DVM, MPVM Amber Rae Williams, DVM Karen Nicole Woodward, DVM West Coast (Southern California) Trinka Adamson, MS, DVM, DACLAM – Coordinator James Finlay, DVM, PhD, DACLAM - Coordinator Yvonne Cornejo, DVM Leo Holguin, DVM Marissa Saenz, DVM Melanie Sailor, MLAS, DVM Rose Tu, DVM 5 1. Which statement best describes the sexual dimorphism observed in bullfrogs? a. Male has tympanum larger than the eye and develops keratin pads on their thumbs b. Male has tympanum the same diameter as the eye and develops keratin pads on their thumbs c. Female has tympanum the same diameter as the eye and develops keratin pads on their thumbs d. Female does not have tympanum and does not develop keratin pads on their thumbs Answer: a. Male has tympanum larger than the eye and develops keratin pads on their thumbs Reference: 1) Fox JG, Anderson LC, Otto G, Pritchett-Corning KR, Whary MT, eds. 2015. Laboratory Animal Medicine, 3rd edition. Academic Press: San Diego, CA. Chapter 18 – Biology and Disease of Amphibians, p. 943 Domain 1; Tertiary Species – Other Amphibians 2. Which of the following injectable anesthetics has no known active metabolites and 90% of it is excreted in the urine? a. Avertin b. Ketamine c. Pentobarbital d. Propofol e. Xylazine Answer: d. Propofol References: 1) Fish RE, Brown MJ, Danneman PJ, Karas AZ, eds. 2008. Anesthesia and Analgesia in Laboratory Animals, 2nd ed. Academic Press, San Diego, CA. Chapter 10 – Anesthesia and Analgesia for Laboratory Rodents, pp. 257-261 2) Fox JG, Anderson LC, Otto G, Pritchett-Corning KR, Whary MT, eds. 2015. Laboratory Animal Medicine, 3rd edition. Academic Press: San Diego, CA. Chapter 24 - Preanesthesia, Anesthesia, Analgesia and Euthanasia, pp. 1140-1141, 1143 Domain 2 3. The Bovine Corneal Opacity and Permeability Test has been validated and accepted by Federal agencies as an alternative for which of the following animal models for screening product toxicity? a. Rabbit Pyrogen Test b. Rabbit Draize Test c. Guinea Pig Maximization Test d. Mouse LD50 Botulinum Toxin Potency Bioassay Answer: b. Rabbit Draize Test 6 References: 1) Fox JG, Anderson LC, Otto G, Pritchett-Corning KR, Whary MT, eds. 2015. Laboratory Animal Medicine, 3rd edition. Academic Press: San Diego, CA. Chapter 39 – Animal Welfare, PP 1659-1660. 2) Suckow MA, Stevens KA, Wilson RP, eds. 2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. Academic Press/Elsevier: San Diego, CA. Section I – General, Chapter 1 – Ethical Considerations and Regulating Issues, p. 9 Domain 3; Primary Species – Rabbit (Oryctolagus cuniculus) 4. All of following statements apply to management and husbandry of Syrian hamsters EXCEPT? a. Placement of feed directly on the cage floor is preferred for both adult and young hamsters b. Exposure to cold stimulates hamsters to gather food and to hibernate at a temperature of approximately 5oC c. Breeding pairs/trios should include a male hamster that is younger than the female(s) d. Providing nesting material is recommended as hamsters of both sexes make nests Answer: c. Breeding pairs/trios include a male hamster that is younger than the female(s) References: 1) Fox JG, Anderson LC, Otto G, Pritchett-Corning KR, Whary MT, eds. 2015. Laboratory Animal Medicine, 3rd edition. Academic Press: San Diego, CA. Chapter 5 – Biology and Diseases of Hamsters, pp. 215-219 2) Suckow MA, Stevens KA, Wilson RP, eds. 2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. Academic Press/Elsevier: San Diego, CA. Section IV – Hamsters, Chapter 28 – Management, Husbandry, and Colony Health, pp. 767-770 Domain 4; Secondary Species – Syrian Hamster (Mesocricetus auratus) 5. According to the AVMA Guidelines for Euthanasia of Animals (2013 Edition), which of the following would be considered unacceptable in mice? a. Carbon monoxide
Recommended publications
  • Diet-Induced Metabolic Syndrome in Rodent Models
    Diet-Induced Metabolic Syndrome in Rodent Models A discussion of how diets made from purified ingredients influence the phenotypes of the MS in commonly used rodent models. Angela M. Gajda, MS, Michael A. Pellizzon, Ph.D., Matthew R. Ricci, Ph.D. and Edward A. Ulman, Ph.D. quick look at a crowd of people shows was not stable and periods of starvation were that many of our fellow humans are car- common, it was advantageous to have genes that rying around too much excess weight. allowed for the efficient storage of excess calories The prevalence of obesity is at epidemic as fat, given the uncertainty of when the next Alevels in the developed world, and obesity may be meal would come. In our present society, the the root cause of or precursor to other diseases problem is that we still have those ‘thrifty genes’ such as insulin resistance, abnormal blood lipid but also have a variety of foods that are high in levels (hypertriglyceridemia and reduced high saturated fat, simple sugars, and salt. density lipoprotein cholesterol), and hyperten- Unfortunately for us, many of these foods are sion (high blood pressure). The term ‘metabolic inexpensive and highly accessible (not to men- syndrome’ (MS) is used to describe the simulta- tion very tasty), and we find them easy to con- neous occurrence of these diseases and people sume in excess, leading to disease and most like- with the MS are at increased risk for type 2 dia- ly early death. On the flip side of caloric intake betes, cardiovascular disease, cancer, and non- coin is the very interesting finding that long-term alcoholic fatty liver disease.
    [Show full text]
  • The Use of Non-Human Primates in Research in Primates Non-Human of Use The
    The use of non-human primates in research The use of non-human primates in research A working group report chaired by Sir David Weatherall FRS FMedSci Report sponsored by: Academy of Medical Sciences Medical Research Council The Royal Society Wellcome Trust 10 Carlton House Terrace 20 Park Crescent 6-9 Carlton House Terrace 215 Euston Road London, SW1Y 5AH London, W1B 1AL London, SW1Y 5AG London, NW1 2BE December 2006 December Tel: +44(0)20 7969 5288 Tel: +44(0)20 7636 5422 Tel: +44(0)20 7451 2590 Tel: +44(0)20 7611 8888 Fax: +44(0)20 7969 5298 Fax: +44(0)20 7436 6179 Fax: +44(0)20 7451 2692 Fax: +44(0)20 7611 8545 Email: E-mail: E-mail: E-mail: [email protected] [email protected] [email protected] [email protected] Web: www.acmedsci.ac.uk Web: www.mrc.ac.uk Web: www.royalsoc.ac.uk Web: www.wellcome.ac.uk December 2006 The use of non-human primates in research A working group report chaired by Sir David Weatheall FRS FMedSci December 2006 Sponsors’ statement The use of non-human primates continues to be one the most contentious areas of biological and medical research. The publication of this independent report into the scientific basis for the past, current and future role of non-human primates in research is both a necessary and timely contribution to the debate. We emphasise that members of the working group have worked independently of the four sponsoring organisations. Our organisations did not provide input into the report’s content, conclusions or recommendations.
    [Show full text]
  • Laboratory Animal Management: Rodents
    THE NATIONAL ACADEMIES PRESS This PDF is available at http://nap.edu/2119 SHARE Rodents (1996) DETAILS 180 pages | 6 x 9 | PAPERBACK ISBN 978-0-309-04936-8 | DOI 10.17226/2119 CONTRIBUTORS GET THIS BOOK Committee on Rodents, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council FIND RELATED TITLES SUGGESTED CITATION National Research Council 1996. Rodents. Washington, DC: The National Academies Press. https://doi.org/10.17226/2119. Visit the National Academies Press at NAP.edu and login or register to get: – Access to free PDF downloads of thousands of scientific reports – 10% off the price of print titles – Email or social media notifications of new titles related to your interests – Special offers and discounts Distribution, posting, or copying of this PDF is strictly prohibited without written permission of the National Academies Press. (Request Permission) Unless otherwise indicated, all materials in this PDF are copyrighted by the National Academy of Sciences. Copyright © National Academy of Sciences. All rights reserved. Rodents i Laboratory Animal Management Rodents Committee on Rodents Institute of Laboratory Animal Resources Commission on Life Sciences National Research Council NATIONAL ACADEMY PRESS Washington, D.C.1996 Copyright National Academy of Sciences. All rights reserved. Rodents ii National Academy Press 2101 Constitution Avenue, N.W. Washington, D.C. 20418 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.
    [Show full text]
  • Non-Human Primates in Biomedical Research
    Science Shop for Biology Non-human primates in biomedical research Frouke Pieters P-UB-2006-06 Non-human primates in biomedical research Reasons and alternatives for their use Frouke Pieters Science shop for Biology Netherlands Centre Alternatives to Animal Use, Utrecht University, The Netherlands April 2007 P-UB-2006-06 Colofon Report number P-UB-2006-06 ISBN 978-90-5209-158-7 Price € 5,- Publication date April 2007 Edition First Title Non-human primates in biomedical research Reasons and alternatives for their use Author Frouke Pieters Supervisor Prof. Dr. C. Hendriksen, Netherlands Centre Alternatives to animal use, Utrecht University, The Netherlands Project coordinator Ir. M. A. Vaal, Science Shop for Biology, Utrecht University Commissioned by Working party 'Primate Research in the Netherlands' under the auspices of the Dutch Association for Laboratory Animal Science, Amsterdam Reproduction Document Diensten Centrum Uithof Publisher Science shop for Biology, Utrecht University Padualaan 8, 3584 CH Utrecht, The Netherlands. .. 31 30 253 7363 www.bio.uu.nl/scienceshop Copyright This document (or parts thereof) may not be multiplied in any form. Parts of the document may be used for other publications, if a reference is included. Contents Preface 5 Summary 7 Samenvatting 8 1 Introduction 9 1.1 Motivation 9 1.2 Definition of the problem 10 1.3 Scope and definitions 10 1.4 Approach 11 1.5 Structure 12 2 Use of primates 13 2.1 Figures 13 2.2 Goals of primate studies 18 2.3 Regulations on animal experimentation 21 2.4 Ethics 22 2.5 Problems
    [Show full text]
  • Little Appetite for Obesity: Meta-Analysis of the Effects of Maternal Obesogenic Diets on Offspring Food Intake and Body Mass in Rodents
    International Journal of Obesity (2015) 39, 1669–1678 © 2015 Macmillan Publishers Limited All rights reserved 0307-0565/15 www.nature.com/ijo REVIEW Little appetite for obesity: meta-analysis of the effects of maternal obesogenic diets on offspring food intake and body mass in rodents M Lagisz1,2,3, H Blair4, P Kenyon4, T Uller5, D Raubenheimer6,7 and S Nakagawa1,2,3 BACKGROUND: There is increasing recognition that maternal effects contribute to variation in individual food intake and metabolism. For example, many experimental studies on model animals have reported the effect of a maternal obesogenic diet during pregnancy on the appetite of offspring. However, the consistency of effects and the causes of variation among studies remain poorly understood. METHODS: After a systematic search for relevant publications, we selected 53 studies on rats and mice for a meta-analysis. We extracted and analysed data on the differences in food intake and body weight between offspring of dams fed obesogenic diets and dams fed standard diets during gestation. We used meta-regression to study predictors of the strength and direction of the effect sizes. RESULTS: We found that experimental offspring tended to eat more than control offspring but this difference was small and not statistically significant (0.198, 95% highest posterior density (HPD) = − 0.118–0.627). However, offspring from dams on obesogenic diets were significantly heavier than offspring of control dams (0.591, 95% HPD = 0.052–1.056). Meta-regression analysis revealed no significant influences of tested predictor variables (for example, use of choice vs no-choice maternal diet, offspring sex) on differences in offspring appetite.
    [Show full text]
  • Environmental Enrichment for Nonhuman Primates Resource Guide [Electronic Resource] AWIC Resource Series No
    United States Department of Agriculture Environmental Enrichment Agricultural Research Service for Nonhuman Primates National Agricultural Library Resource Guide Animal Welfare Information Center 2006 (Updated October 2009) Photo courtesy Photos8.com AWIC Resource Series No. 32 United States Department of Environmental Agriculture Enrichment for Agricultural Research Service Nonhuman Primates National Agricultural Resource Guide Library AWIC Resource Series No. 32 Animal Welfare Information Center 2006 (Updated October 2009) Compiled by: Kristina M. Adams, M.S. Animal Welfare Information Center National Agricultural Library U.S. Department of Agriculture Beltsville, Maryland 20705 E-mail: [email protected] Web site: http://awic.nal.usda.gov Available online: http://www.nal.usda.gov/awic/pubs/Primates2009/primates.shtml National Agricultural Library Cataloging Record Adams, Kristina M. Environmental Enrichment for Nonhuman Primates Resource Guide [electronic resource] AWIC Resource Series No. 32, Updated 1. Environmental enrichment (Animal culture) -- Bibliography. 2. Primates -- Environmental Enrichment -- Bibliography. I. Animal Welfare Information Center (U.S.) II. Title. aHV4701 .A94 no. 32, Updated Disclaimers The U.S. Department of Agriculture (USDA) prohibits discrimination in all its programs and activities on the basis of race, color, national origin, age, disability, and where applicable, sex, marital status, familial status, parental status, religion, sexual orientation, genetic information, political beliefs, reprisal, or because all or a part of an individual’s income is derived from any public assistance program. (Not all prohibited bases apply to all programs.) Persons with disabilities who require alternative means for communication of program information (Braille, large print, audiotape, etc.) should contact USDA’s TARGET Center at (202) 720-2600 (voice and TDD).
    [Show full text]
  • The Genetic Basis of Diurnal Preference in Drosophila Melanogaster 1 Mirko Pegoraro1,4, Laura M.M. Flavell1, Pamela Menegazzi2
    bioRxiv preprint doi: https://doi.org/10.1101/380733; this version posted August 2, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 The genetic basis of diurnal preference in Drosophila melanogaster 2 Mirko Pegoraro1,4, Laura M.M. Flavell1, Pamela Menegazzi2, Perrine Colombi1, Pauline 3 Dao1, Charlotte Helfrich-Förster2 and Eran Tauber1,3 4 5 1. Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK 6 2. Neurobiology and Genetics, Biocenter, University of Würzburg, Germany 7 3. Department of Evolutionary and Environmental Biology, and Institute of Evolution, 8 University of Haifa, Haifa 3498838, Israel 9 4. School of Natural Science and Psychology, Liverpool John Moores University, L3 3AF, UK 10 11 12 Corresponding author: E. Tauber, Department of Evolutionary and Environmental Biology, 13 and Institute of Evolution, University of Haifa, Haifa 3498838, Israel; Tel:+97248288784 14 Email: [email protected] 15 16 17 Classification: Biological Sciences (Genetics) 18 19 20 Keywords: Artificial selection, circadian clock, diurnal preference, nocturnality, 21 Drosophila 22 23 24 bioRxiv preprint doi: https://doi.org/10.1101/380733; this version posted August 2, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license.
    [Show full text]
  • Accountability
    ACCOUNTABILITY animal experiments & freedom of information The assessment of projects under the Animals (Scientific Procedures) Act 1986 The licensing process The Animal Procedures Committee The application of Nolan principles ACCOUNTABILITY animal experiments & freedom of information - a parliamentary briefing CONTENTS 1. Introduction 1 2. Background 2 3. Secrecy vs Transparency 5 4. Put it to the test 9 5. The Animal Procedures Committee 13 6. Reform of the APC 16 7. Local Ethics Committees 21 8. Conclusions 25 Appendix: Profile of current members of the APC 261 Goldhawk Road, London W12 9PE. Tel. 0181 846 9777 Fax. 0181 846 9712 e-mail: [email protected] Web: http://www.cygnet.co.uk/navs ©NAVS 1997 ACCOUNTABILITY 1. Introduction There is undoubtedly considerable public disquiet that cruel, unnecessary or repetitive research continues on animals in British laboratories. Bland government assurances that our legislation is the ‘best in the world’ do not convince a public now familiar with video and photographic evidence of the reality of animal experimentation. The secrecy with which the law is administered only hardens the conviction that there is something to hide. Well documented evidence from the NAVS and others has shown that government guidelines and the ‘Code of Practice for the Housing and Care of Laboratory Animals’ are not diligently enforced and that the Home Office leans towards protection of vivisection industry interests rather than towards serving the public will. It has taken undercover investigations to expose serious abuses within the system. In March 1997 a Channel 4 investigation led to the threat of the revocation of the Certificate of Designation for Huntingdon Life Sciences and the prosecution of former staff members.
    [Show full text]
  • Platforms and Funds for Alternatives to Animal Experimentation
    Platforms and Funds for Alternatives to Animal Experimentation Live Kleveland A report from The Norwegian Reference Centre for Laboratory Animal Science & Alternatives, Norwegian School of Veterinary Science, Oslo, Norway 2005 ISBN 82-7725-120-3 This is a revised version of the report, after circulation to representatives of all ecopa platforms for approval. CONTENTS INTRODUCTION _____________________________________________________ 3 ACKNOWLEDGEMENTS ______________________________________________ 4 ECOPA AND EUROPEAN CONSENSUS-PLATFORMS FOR ALTERNATIVES TO ANIMAL EXPERIMENTATION _____________________________________ 5 Austria ______________________________________________________________ 5 Belgium _____________________________________________________________ 6 The Czech Republic ____________________________________________________ 6 Finland______________________________________________________________ 7 Germany_____________________________________________________________ 8 Italy_________________________________________________________________ 8 The Netherlands ______________________________________________________ 9 Spain_______________________________________________________________ 10 Sweden _____________________________________________________________ 11 Switzerland__________________________________________________________ 12 The UK _____________________________________________________________ 13 SUMMARY OF CONSENSUS-PLATFORMS FOR ALTERNATIVES TO ANIMAL EXPERIMENTATION ________________________________________________ 15 FUNDING OF
    [Show full text]
  • Animal Models of Obesity in Rodents. an Integrative Review1
    10 - REVIEW Animal models of obesity in rodents. An integrative review1 Melina Ribeiro FernandesI, Nayara Vieira de LimaI, Karoline Silva RezendeI, Isabela Caroline Marques SantosI, Iandara Schettert SilvaII, Rita de Cássia Avellaneda GuimarãesIII DOI: http://dx.doi.org/10.1590/S0102-865020160120000010 Trabalho apresentado no XV Congresso Internacional de Cirurgia Experimental-SOBRADPEC e II Fórum de Pós-Graduação em Ciências da Saúde da Região Centro-Oeste, Campo Grande-MS. 23 a 26 de novembro/2016. ABSTRACT PURPOSE: To perform an integrative review of the main animal disease models in rodents used for obesity. METHODS: Research was conducted in the CAPES Portal database using the following keywords “obesity animal models, diet and rodents”, published between the years 2010 to 2016. We found 108 articles, of which 19 were selected and analyzed in full for this study. RESULTS: Larger part of publications occurred in the last 6 years, the rats (n = 10) were used in the same proportion mice (n = 10). The choice of male animals (n = 18) and age greater than 21 days (n = 17) showed a major highlight. The greater than 5 week follow-up period (n = 18) was the most applied. A High Fat Diet was the most used in studies (n = 18). CONCLUSIONS: Male rodents continue to be considered the species most used in experimental studies to induce obesity, also was found variations of age to the beginning of the experiment. For the most part are follow-up time studies along with the use of High Fat Diet. Key words: Obesity. Animal Experimentation. Diet. Rodentia. 840 - Acta Cirúrgica Brasileira - Vol.
    [Show full text]
  • UCAR Manual on the Responsible Care and Use of Laboratory Animals
    University Committee on Animal Resources Manual on the Responsible Care and Use of Laboratory Animals 1 Contents Preface 3 Chapter 1. Regulations and Requirements 4 IACUC 4 Animal Use Categories 6 Chapter 2. Biomethodology of Laboratory Animals 12 Table 1: Drug Dosage, anesthesia and analgesia 13 Euthanasia 21 Handling of Common Laboratory Animals 22 Rodent Identification 25 DLAM Mouse Tail Biopsy SOP 26 Fluid and Drug Administration 28 Blood Collection 32 Guidelines for Aseptic Recovery Surgery on USDA Regulated Species 35 Guidelines for Aseptic Recovery Surgery on Rodents and Birds 39 University Policy on Major Invasive Surgery (Ooctye Harvest) on Frogs 41 Chapter 3. Alternatives: Replacement, Refinement, Reduction 42 2 Preface The cornerstone of responsible care and use of laboratory animals in a research facility is an institutional commitment to a strong training and continuing education program. The dynamic nature of biomedical research requires that we keep abreast of changes in regulations and refinements in research techniques. The University of Rochester Manual On The Responsible Care And Use of Laboratory Animals guides researchers through existing regulations and instructs personnel about humane methods of animal maintenance and experimentation. The Manual is one part of a multifaceted training program available to research personnel and animal care technicians at the University of Rochester. Individual training in specific techniques of biomethodology is available for researchers contemplating a new animal model or developing an experimental technique. A periodic Newsletter and updated pages to the Manual will keep you informed of legislative trends, aware of animal care and use issues at the University of Rochester, and current with new techniques in laboratory animal research.
    [Show full text]
  • Evolutionary History of the Brown Rat: out of Southern East Asia And
    bioRxiv preprint doi: https://doi.org/10.1101/096800; this version posted December 26, 2016. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Evolutionary history of the brown rat: out of southern East Asia and selection Lin Zeng †,1,12, Chen Ming †,19,20, Yan Li 1,4, Ling-Yan Su 2,12, Yan-Hua Su 3, Newton O. Otecko 1,12,21, Ambroise Dalecky 8,9, Stephen Donnellan 13, Ken Aplin 14, Xiao-Hui Liu 5, Ying Song 5, Zhi-Bin Zhang 6, Ali Esmailizadeh 7, Saeed S. Sohrabi 7, Hojjat Asadollahpour Nanaei 7, He-Qun Liu 1,12, Ming-Shan Wang 1,12, Solimane Ag Atteynine 15,16, Gérard Rocamora 17, Fabrice Brescia 18, Serge Morand 10, David M. Irwin 1,11, Ming-sheng Peng 1,12,21, Yong-Gang Yao 2,12, Haipeng Li *,19, Dong-Dong Wu *,1,12,21, Ya-Ping Zhang *,1,4,12 1. State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China 3. College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China. 4. Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China 5. State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China 6.
    [Show full text]