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Herpes: a Patient's Guide
Herpes: A Patient’s Guide Herpes: A Patient’s Guide Introduction Herpes is a very common infection that is passed through HSV-1 and HSV-2: what’s in a name? ....................................................................3 skin-to-skin contact. Canadian studies have estimated that up to 89% of Canadians have been exposed to herpes simplex Herpes symptoms .........................................................................................................4 type 1 (HSV-1), which usually shows up as cold sores on the Herpes transmission: how do you get herpes? ................................................6 mouth. In a British Columbia study, about 15% of people tested positive for herpes simplex type 2 (HSV-2), which Herpes testing: when is it useful? ..........................................................................8 is the type of herpes most commonly thought of as genital herpes. Recently, HSV-1 has been showing up more and Herpes treatment: managing your symptoms ...................................................10 more on the genitals. Some people can have both types of What does herpes mean to you: receiving a new diagnosis ......................12 herpes. Most people have such minor symptoms that they don’t even know they have herpes. What does herpes mean to you: accepting your diagnosis ........................14 While herpes is very common, it also carries a lot of stigma. What does herpes mean to you: dating with herpes ....................................16 This stigma can lead to anxiety, fear and misinformation -
Intracellular Lipid Droplet Accumulation Occurs Early Following Viral Infection and Is Required for an Efficient Interferon Response
ARTICLE https://doi.org/10.1038/s41467-021-24632-5 OPEN Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response E. A. Monson 1, K. M. Crosse1, M. Duan2, W. Chen 2,R.D.O’Shea 1, L. M. Wakim3, J. M. Carr 4, ✉ D. R. Whelan2 & K. J. Helbig 1 1234567890():,; Lipid droplets (LDs) are increasingly recognized as critical organelles in signalling events, transient protein sequestration and inter-organelle interactions. However, the role LDs play in antiviral innate immune pathways remains unknown. Here we demonstrate that induction of LDs occurs as early as 2 h post-viral infection, is transient and returns to basal levels by 72 h. This phenomenon occurs following viral infections, both in vitro and in vivo. Virally driven in vitro LD induction is type-I interferon (IFN) independent, and dependent on Epidermal Growth Factor Receptor (EGFR) engagement, offering an alternate mechanism of LD induction in comparison to our traditional understanding of their biogenesis. Additionally, LD induction corresponds with enhanced cellular type-I and -III IFN production in infected cells, with enhanced LD accumulation decreasing viral replication of both Herpes Simplex virus 1 (HSV-1) and Zika virus (ZIKV). Here, we demonstrate, that LDs play vital roles in facilitating the magnitude of the early antiviral immune response specifically through the enhanced modulation of IFN following viral infection, and control of viral replication. By identifying LDs as a critical signalling organelle, this data represents a paradigm shift in our understanding of the molecular mechanisms which coordinate an effective antiviral response. -
Multiple Sclerosis
What Really Causes Multiple Sclerosis HAROLD D. FOSTER i AUTHOR’S NOTE This book is written and published to provide information on multiple sclerosis. It is sold with the understanding that the publisher and author are not engaged in rendering legal, medical, or other professional services. In addition, this book is not to be used in the diagnosis of any medical condition. If “expert” assistance is desired or required, the services of a competent professional, especially one who is an expert in nutrition, should be sought. Every effort has been made to make this book as complete and accurate as possible. However, there may be mistakes both typographical and in content. Therefore, this text should be used as a general guide and not as the ultimate source of information. Factual matters can be checked by reading the cited literature. This book seeks to stimulate, educate, and entertain. The publisher and the author shall have neither liability nor responsibility to any entity or person with respect to any loss or damage caused, or alleged to be caused, directly or indirectly by the concepts or information contained in this book. Anyone not wishing to be bound by the above may return this volume for a refund of its purchase price. ACKNOWLEDGEMENTS The unusual cover of this book was designed, as were the other covers in this series, by Ken Josephson. It is based on the painting “Shattered Nerves” by Keith Loreth. My thanks go to both Ken and Keith for their creativity and generosity. I would also like to thank Dr. Abram Hoffer and Dr. -
65 Watching Television in Australia: a Story of Innocence and Experience
Watching Television in Australia: A Story of Innocence and Experience Susan Bye School of Communication, Arts and Critical Enquiry La Trobe University Abstract The excitement and naiveté of early viewers have become central to narratives of the Australian viewing past. These stories are of simpler times when the pleasure of watching television was unmediated by modern self-consciousness and cynicism. This popular way of ‘remembering’ television seems both natural and inevitable, but its role as a discursive strategy is highlighted by the alacrity with which TV columnists sought to bestow a sense of experience on fledgling Sydney viewers. In this paper, I focus on the way that the regular TV column worked to stitch readers into the daily business of television. Moreover, from the beginning of regular broadcasting, TV columnists challenged the idea that watching television was an identity- subsuming process and invited their readers to assume an active connection with television and its culture. Keywords: Audiences, Australian Television, Everyday Life, TV Columns Introduction The construction of television viewing history as progressive or developmental is not peculiar to the Australian context but, in the Australian situation, the popular association of early television with the fifties has allowed it and its audience to be collapsed into the ‘fifties story’. Imagined simultaneously as a time of innocence and a period of narrow-mindedness, the dominant narrative of Australia in the fifties involves a perception of a simple and insular people readily committing to family life in the suburbs (White 1983). This monochromatic understanding of suburban life in fifties Australia has effortlessly intersected with a similarly tidy conception of the relationship of early TV viewers to the new technology of television. -
11111 11111 Lat
11111 11111 Lat ESOLUTION TEST CHART DOCUMENT RESUME ED 054 622 ER 009 205 AUTHOR Powell, R. J. TITLE Television Viewing by Young Secondary Students: A Study of the Television Viewing Behavior ofChildren at Form Two Level. INSTITUTION Australian Broadca ting Control Board, Melbourne. PUB DATE 71 NOTE 37p. EDRS PRICE MF-$0.65 HC-$3.29 DESCRIPTORS *Adolescents; Audiences; Commercial Television; Individual Characteristics; Intelligence; Parent Influence; Peer Acceptance; *Personality; Recreational Activities; Television; *Television Research; Television Surveys; 4Te1evisionViewing; Viewing Time ABSTRACT Television viewing habits of 12 to 14 year oldsin Australia were studied, and an attempt was made tocorrelate amount of viewing time and choice of programs withthese childrenls intelligence and personality. Average viewingtime per night was three hours and 40 minutes. A large variation wasfound in the time at which children ceased viewing. The study found nosignificant difference in amount of viewing done by high and lowintelligence groups, although children of highintelligence spent more time watching the non-commercial channel and documentary programs.Those children who watched little television fellin two groups. The first group had IQs of 110-120 andhad parents who restricted their viewing and had high educational expectations fortheir children. The second group had tQs above 120 andlittle parental restriction. High intensity viewers were generally less acceptable totheir peer group than were low intensity viewers. On the whole,however, it was found that no significant correlations existbetween viewing choices or amounts and personality scales. (JK) TELEVISION VIEW Y YOUNG SECONDARY STUDENTS A Study of the Television Viewing Behaviour of Children at Form Two Level by R. -
Beispiel-Buch2.Pdf
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Statue of Liberty and Oppression Finland Watches Closely As Estonia’S Statue Crisis Unfolds
ISSUE 1 • 9 – 15 MAY 2007 • €3 INTERNATIONAL NEWS FINLAND NEWS SPORT Mamma Mia! Afghan - Finland’s Lions CULTURE page 16 foreign nuclear need a forces debate killer Nokia unveils train together hots up instinct Barracuda page 12 page 7 page 5 BUSINESS page 10 LEHTIKUVA / HEIKKI SAUKKOMAA Statue of liberty and oppression Finland watches closely as Estonia’s statue crisis unfolds ESTONIA'S prime minister Andrus fence of Estonia, while appealing Ansip has appealed for calm dur- to both Russia and Estonia to calm ing the anniversary of the Soviet tensions. Red Army’s World War Two victo- Estonia has been shocked by ry over Nazi Germany. Victory Day the riots in which one person died, events are held in Estonia and Rus- more than 150 were injured, and sia on Tuesday and Wednesday. about 800 people were arrest- The controversial relocation of ed. A national debate has ensued a monument to the Red Army sol- about the strained relationship be- diers who died during World War tween the Estonian majority and Two sparked riots by Russian res- Russian minority of the country’s idents in Tallinn, Estonia’s capi- population. tal city, on 27 April. The disputed The political repercussions of bronze soldier – a symbol of libera- the crisis have also been felt across tion from Nazism for the Russians Europe, not least in Finland. Rus- and a symbol of Soviet oppression sia’s readiness to threaten Estonia for Estonians – now stands in the by orchestrating a siege of its em- military cemetery in Tallinn. bassy in Moscow, cutting oil sup- The Victory Day events are be- plies and restricting trade, has Andorra’s Anonymous perform their song Let’s save the World during the Eurovision Song Contest rehearsals in Helsinki. -
Drought Aid Subsidy
i . 's -T’ » V..w' Vr; f TAGE TWENTY-FOUr WEDNESDAY, SEPTEMBER 11, 1»57 Average Daily Net Preen Run lKan(I|(Bt?r lEnratng 9|?raUi Tha Weather TT- Far the Weak Ended raowaaaler V. •. W w l^ OaNUa , Sept. 1, 1857 ' ■ '■>1 company, where Miss Benson is tara of Marey managa tha hofna, a In MMH Po8t Two Showew Held employed, attended the party and Farniture Needed St. A ^es Guild haven for unwad mothers and their Fair, aolM toalglit, fag la*a 9a- About Town shower^ her with miscellaneous infanta, regardlesa of race, creed or 12,456 alght. Law 8046. Friday w m m . group and individual gifts. She un First , For Carol Btenson The Town Welfare' Depiart- To Close Drive color. hoamld; $4mnee of alkomewa Omw- Wwmrd Moriarty, chairman, of wrapped them while seated be Member of the Audit ment has requested a "helping SL Bridget'i, St. Jamea’ and the Bureau of Qrenlatlon en.'Hlgli M arid 8*0. ; tha Khifhta of Columbua Mthack neath a watering can decorated In hand" from Manchester resi Church of the Assumption all have Showing Iao|ua committao, announcM them Mias Carol L. Benson of 7S the wedding colors of peaoh and The annual membership drive by Manche»ter— A City of Villftge Charm Princeton St. was honored recently dents. The department needs a. St. Agnea Guild, for the benefit of committees which solicit member- ar* aUll openinCB for teams con- green. kitchch set, a living room set, Bhips. Members are Mrs. Williams, slatlnf of four plaj'ers. The league with two bridal showers. -
QUADERNI Dell’Italian Journal NE 2017 – VOLU M of Medicine
volume 5 ISSUE 7 2017 settembre SSUE 7 I E 5 – M QUADERNI dell’Italian Journal NE 2017 – VOLU ICI of Medicine A Journal of Hospital and Internal Medicine AN JOURNAL OF MED I Editor in Chief The official journal of the Federation of Associations Roberto Nardi of Hospital Doctors on Internal Medicine (FADOI) – ITAL I Non-commercial use only UADERN Q Le malattie infiammatorie immuno-mediate (IMID) di interesse internistico: fisiopatologia, aspetti clinici e prospettive di terapia Guest Editors: A. Fontanella, R. Nardi, M. Masina, G. Uomo PAGEPress - Scientific Publications Via A. Cavagna Sangiuliani, 5 - 27100 Pavia - Italy Phone +39 0382 464340 - Fax +39 0382 34872 www.pagepress.org Q www.italjmed.org SEGRETERIA NAZIONALE Via Felice Grossi Gondi, 49 - 00162 Roma Tel. +39.06.85355188 - Fax: +39.06.85345986 E-mail: [email protected] Società Scientifica FADOI - Organigramma PRESIDENTE NAZIONALE Andrea Fontanella, Napoli, Italy PRESIDENTE ELETTO COORDINATORE COMMISSIONE GIOVANI Dario Manfellotto, Roma, Italy Flavio Tangianu, Oristano, Italy PAST PRESIDENT MEMBRO FISM E RESPONSABILE PER L’INNOVAZIONE IN MEDICINA INTERNA Mauro Campanini, Novara, Italy Antonino Mazzone, Legnano (MI), Italy SEGRETARIO ITALIAN JOURNAL OF MEDICINE Micaela La Regina, La Spezia, Italy Editor in Chief Giorgio Vescovo, Padova, Italy SEGRETARIO VICARIO RESPONSABILE DEI QUADERNI DELL’IJM Andrea Montagnani, Grosseto, Italy E EDIZIONI ON LINE Roberto Nardi, Bologna, Italy STAFF DI SEGRETERIA Comunicazione Paola Gnerre, Savona, Italy DELEGATO FADOI ITALIAN STROKE ORGANIZATION -
A-Z Movies August
AUGUST 2021 A-Z MOVIES 1% Mickey Mantle compete against each Of SHARKBOY Sci-Fi/Fantasy (M lv) Based on a true story. An American John Cleese, Amy Irving. MOVIES PREMIERE 2017 other to break Babe Ruth’s single- AND LAVAGIRL August 7, 16 student spending a semester abroad Lured out to the Old West, Fievel the Drama (MA 15+ alsv) season home run record. MOVIES KIDS 2005 Family Sigourney Weaver, Charles S Dutton. in Perugia, Italy, garners international mouse joins forces with a famed dog After being put into an extended sleep attention after she is put on trial sheriff to thwart a sinister plot. August 22 August 6, 15, 25 Matt Nable, Ryan Corr. 100% WOLF Taylor Lautner, Taylor Dooley. state after her last fight with the aliens, for her part in the murder of British The heir to the throne of a notorious MOVIES FAMILY 2020 Family (PG) A boy’s imaginary superhero friends Ellen Ripley crash-lands onto a planet housemate, Meredith Kercher. AN AMISH MURDER outlaw motorcycle club must betray August 9, 18, 31 come to life and join him on a series which is inhabited by the former LIFETIME MOVIES 2013 his president to save his brother’s life. Jai Courtney, Samara Weaving. of adventures. inmates of a maximum-security prison. AMERIcaN DREAMZ Thriller/Suspense (M av) The heir to a family of werewolves MOVIES COMEDY 2006 Comedy (M ls) August 5, 10, 14, 20, 24, 29 12 STRONG experiences his first transformation ALIEN: RESURRECTION August 13, 19 Neve Campbell, Noam Jenkins. MOVIES ACTION 2018 on his 13th birthday, morphing into THE ADVENTURES OF TOM MOVIES GREATS 1997 Hugh Grant, Dennis Quaid. -
Rational Design of Live-Attenuated Vaccines Against Herpes Simplex Viruses
viruses Review Rational Design of Live-Attenuated Vaccines against Herpes Simplex Viruses Brent A. Stanfield 1, Konstantin G. Kousoulas 2,3,*, Agustin Fernandez 3 and Edward Gershburg 3,* 1 Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA; [email protected] 2 Division of Biotechnology and Molecular Medicine, Louisiana State University, Baton Rouge, LA 70803, USA 3 Rational Vaccines Inc., Woburn, MA 01801, USA; [email protected] * Correspondence: [email protected] (K.G.K.); [email protected] (E.G.) Abstract: Diseases caused by human herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) affect millions of people worldwide and range from fatal encephalitis in neonates and herpes keratitis to orofacial and genital herpes, among other manifestations. The viruses can be shed efficiently by asymptomatic carriers, causing increased rates of infection. Viral transmission occurs through direct contact of mucosal surfaces followed by initial replication of the incoming virus in skin tissues. Subsequently, the viruses infect sensory neurons in the trigeminal and lumbosacral dorsal root ganglia, where they are primarily maintained in a transcriptionally repressed state termed “latency”, which persists for the lifetime of the host. HSV DNA has also been detected in other sympathetic ganglia. Periodically, latent viruses can reactivate, causing ulcerative and often painful lesions primarily at the site of primary infection and proximal sites. In the United States, recurrent genital herpes alone accounts for more than a billion dollars in direct medical costs per year, while there are much higher costs associated with the socio-economic aspects of diseased patients, such as loss of productivity due to mental anguish. -
Global Media Journal - Australian Edition - Volume 3 Issue 2 2009
Global Media Journal - Australian Edition - Volume 3 Issue 2 2009 Reporting in the ‘New Media’ Environment: How Today’s Television Journalists are Recycling Work Practices of the Past. Barbara Alysen – University of Western Sydney Abstract The issue of whether the practice of journalism for new mobile platforms and round-the-clock delivery represents a sharp break with the past or an adaptation of existing practices to meet new circumstances, remains unresolved within the study of Australian journalism. Some analysts see the contemporary news environment as forcing a revolutionary change in professional practice. In television news, for example, this has seen newsrooms addressing the challenges of new competition and reduced budgets by using associated online sites to present first versions of stories, requiring reporters to do more of the production work and more of their work in a ‘live’ environment while also drawing on the public for more of the material from which to generate news. However, the idea that journalism is undergoing a revolutionary shift in practice may owe its appeal, in part, to the relative dearth of historical analysis of work practices within Australian journalism in general, and broadcast journalism in particular. While some practices may, in fact, represent something new occasioned by changes in news media delivery others are more evolutionary and, in some ways, the skills required of journalists working in the ‘new media’ environment echo those required in a very different media environment. Drawing on archival research into television news in Australia, the objective is to compare the nature of work required of television journalists in the current mobile platform and 24-hour delivery markets with those required during a period of change in Australian television journalism in the early 1970s.