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Sleep Disorders, Medicine & Integrative conferenceseries.com 834th Conference 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA Scientific Tracks & Abstracts Sleep medicine & Integrative Medicine 2016 Page 23 G Dave Singh et al., J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA Effects of biomimetic oral appliance therapy in adults with obstructive sleep apnea 1G Dave Singh and 2 Felix Liao 1BioModeling Solutions, Inc., Beaverton, USA 2 Whole Health Dental Center, Falls Church, USA iomimetic oral appliance therapy (BOAT) differs from conventional mandibular advancement devices (MADs) that are currently Bdeployed for the management of mild and moderate cases of obstructive sleep apnea (OSA). For example, BOAT attempts to avoid unwanted tooth movements, temporo-mandibular joint issues and undesired facial profile changes that may be associated with long-term MAD use. In addition, in contrast to continuous positive airway pressure (CPAP), BOAT aims to remodel the upper airway through midfacial redevelopment followed by mandibular correction, which may resolve OSA in adults, and possibly avoid long-term CPAP therapy. In this investigation, we test the hypothesis that excessive daytime sleepiness in adults with mild to moderate OSA can be addressed without primary mandibular advancement or CPAP using BOAT. In this pilot study, we included 13 consecutive adults aged >21yrs. that had been diagnosed with mild to moderate OSA, following an overnight sleep study that had been interpreted by a board certified sleep physician. Prior to treatment each subject that participated in this pilot study completed an Epworth Sleepiness Scale (ESS) questionnaire. Each subject was then treated by a general dentist (FL) with advanced training in dental sleep medicine. At each monthly follow-up visit, examination for progress and adjustments of the devices was performed to optimize their efficacy. Post-treatment, each subject completed a follow-up ESS questionnaire. The mean ESS scores of the study sample was calculated prior to and after BOAT. The findings were subjected to statistical analysis, using paired t-tests. There were 7 females and 6 males that participated in this preliminary study. The mean age of the sample was 50yrs. ± 12. Prior to treatment the mean ESS score of the study subjects was 8.2 ± 6. A further follow ESS questionnaire was done at a mean of 29.3 mos. ± 21.5 after BOAT. At this time, the mean ESS score decreased significantly (p < 0.05) to a value of 4.2 ± 3.6 after BOAT, which represents a fall in the mean ESS score by 51.4% for the study sample. We conclude that BOAT may be a useful method of managing adults with OSA who are seeking an alternative to long-term CPAP and MAD use. Although ESS is a discriminating test of daytime sleepiness, further data on the specificity and sensitivity of these initial findings will be obtained using overnight sleep studies in a larger sample size in long-term future studies. Biography Dave Singh was born, educated and trained in England, UK. He holds three doctorates (from the universities of Newcastle, Bristol and Dundee, UK). He is a member of the World Association of Sleep Medicine and World Federation of Orthodontists. He has about 200 publications in the medical, dental and orthodontic literature. Previously, he was Visiting Professor at University of Michigan and University of Hawaii, USA. In addition, at the Center of Craniofacial Disorders, UPR, he led a NIH-NIDCR funded program of research. Currently, he is the CEO of BioModeling Solutions, Inc, and holds several US and international patents. [email protected] Notes: J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016 Page 25 Mohammad A Alqahtani et al, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA Sleep quality and daytime sleepiness in medical students of King Khalid University, Saudi Arabia Mohammad A Alqahtani, Abdulkareem F Alqahtani, Mushabab A. Alshahrani and Hasan Al-Amri King Khalid University, Saudi Arabia Background: Sleep deprivation and symptoms related to sleep disorders are often ignored by medical fraternity; particularly the medical students.Poor sleep quality and sleep problems can have important implications on the academic and work quality of medical students. Objectives: 1. Describe the sleep quality of medical students in King Khalid University. 2. Measure the daytime sleepiness in medical students. 3. Determine the relation between sleep quality and various sleep characteristics. Methods: A cross-sectional study was done on 318 medical students selected by convenience sampling during August -September 2015. A self-administered questionnaire to obtain information regarding socio-demographic variables, indicators of sleep quality and daytime sleepiness was developed using Pittsburg Sleep Quality Index, and the Epworth sleepiness scale. Data was analyzed by using statistical software SPSS version 17.0. Descriptive statistics was reported as means and frequencies. To determine correlation between sleep characteristics and sleep quality, Karl Pearson product-moment correlation coefficient was calculated. Results were considered statistically significant at p ≤ 0.05. Results: A total of 318 students formed our study group (206 males and 112 females).The mean age was 22 years. The mean PQSI score was 6.79 indicating poor sleep quality. Mean bedtime was almost an hour past midnight (12:47am), average sleep latency was approximately 24 minutes and average sleep time was 6 hours. Sleep quality was reported as very good by 109(34.3%) students and ≥85% sleep efficiency was observed in 67.3%.Sleep onset latency more than 30 minutes was reported by16% students. Average daytime sleepiness score was high (8.2), and extreme daytime sleepiness was reported by 159 (50%) students. Correlation between daytime sleepiness, hours of sleep and sleep efficiency with quality of sleep was found significant at the 0.01 level. Biography Abdulkareem F Alqahtani Results of this study provide an insight into the sleep pattern and sleep problems among medical students in King Khalid University, Saudi Arabia. Results reflected poor sleep quality scores coupled with good subjective sleep scores and high daytime sleepiness which indicates an existing sleep gap. The study highlights a pressing need for sensitizing medical students to proper sleep hygiene. [email protected] Notes: J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016 Page 26 Andrew McKinnon, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA Objective sleep disturbance in Mild Cognitive Impairment is associated with alterations in the brain’s Default Mode Network Andrew McKinnon Macquarie University, Australia his study aimed to identify Default Mode Network (DMN) functional connectivity deficits in patients with Mild Cognitive TImpairment (MCI) and sleep disturbance, relative to those with MCI and no sleep disturbance. It is a follow-up study to our prior research, which demonstrated connectivity deficits in those with self-reported sleep disturbances. The current study utilises objective sleep measurement via actigraphy to investigate. A total of 47 older adults aged 55 years and over were recruited, comprising 15 cognitively intact controls and 32 health-seeking patients.Participants underwent resting-state fMRI along with comprehensive neuropsychological, medical, psychiatric and actigraphic assessments. MCIs demonstrated significantly reduced functional connectivity relative to controls across several temporal and parietal brain regions. Relative to those without sleep disturbance, sleep-disturbed MCI participants also demonstrated significantly diminished DMN connectivity between a number of temporal and parietal regions, however the affected areas and connections differed from those revealed by the control analysis. All of these connections remained significant after controlling for antidepressant usage except one, which became borderline non-significant. Sleep disturbance in MCI is associated with DMN functional connectivity deficits in brain regions underpinning salient memory and sleep systems. These results build on our previous research and indicate that both subjective and objective sleep disturbances are associated with reductions in functional connectivty across key DMN nodes. Biography Andrew is a graduate student undertaking the final year of a combined PhD/Master of Clinical Neuropsychology degree at Macquarie University, Sydney, Australia. He has published 4 papers in peer-reviewed journals, including 2 from his PhD. [email protected] Notes: J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016 Page 27 Yaron Haviv, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005
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