conferenceseries.com 834th Conference 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA Scientific Tracks & Abstracts
Sleep medicine & Integrative Medicine 2016
Page 23 G Dave Singh et al., J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Effects of biomimetic oral appliance therapy in adults with obstructive sleep apnea 1G Dave Singh and 2 Felix Liao 1BioModeling Solutions, Inc., Beaverton, USA 2 Whole Health Dental Center, Falls Church, USA
iomimetic oral appliance therapy (BOAT) differs from conventional mandibular advancement devices (MADs) that are currently Bdeployed for the management of mild and moderate cases of obstructive sleep apnea (OSA). For example, BOAT attempts to avoid unwanted tooth movements, temporo-mandibular joint issues and undesired facial profile changes that may be associated with long-term MAD use. In addition, in contrast to continuous positive airway pressure (CPAP), BOAT aims to remodel the upper airway through midfacial redevelopment followed by mandibular correction, which may resolve OSA in adults, and possibly avoid long-term CPAP therapy. In this investigation, we test the hypothesis that excessive daytime sleepiness in adults with mild to moderate OSA can be addressed without primary mandibular advancement or CPAP using BOAT. In this pilot study, we included 13 consecutive adults aged >21yrs. that had been diagnosed with mild to moderate OSA, following an overnight sleep study that had been interpreted by a board certified sleep physician. Prior to treatment each subject that participated in this pilot study completed an Epworth Sleepiness Scale (ESS) questionnaire. Each subject was then treated by a general dentist (FL) with advanced training in dental sleep medicine. At each monthly follow-up visit, examination for progress and adjustments of the devices was performed to optimize their efficacy. Post-treatment, each subject completed a follow-up ESS questionnaire. The mean ESS scores of the study sample was calculated prior to and after BOAT. The findings were subjected to statistical analysis, using paired t-tests. There were 7 females and 6 males that participated in this preliminary study. The mean age of the sample was 50yrs. ± 12. Prior to treatment the mean ESS score of the study subjects was 8.2 ± 6. A further follow ESS questionnaire was done at a mean of 29.3 mos. ± 21.5 after BOAT. At this time, the mean ESS score decreased significantly (p < 0.05) to a value of 4.2 ± 3.6 after BOAT, which represents a fall in the mean ESS score by 51.4% for the study sample. We conclude that BOAT may be a useful method of managing adults with OSA who are seeking an alternative to long-term CPAP and MAD use. Although ESS is a discriminating test of daytime sleepiness, further data on the specificity and sensitivity of these initial findings will be obtained using overnight sleep studies in a larger sample size in long-term future studies.
Biography Dave Singh was born, educated and trained in England, UK. He holds three doctorates (from the universities of Newcastle, Bristol and Dundee, UK). He is a member of the World Association of Sleep Medicine and World Federation of Orthodontists. He has about 200 publications in the medical, dental and orthodontic literature. Previously, he was Visiting Professor at University of Michigan and University of Hawaii, USA. In addition, at the Center of Craniofacial Disorders, UPR, he led a NIH-NIDCR funded program of research. Currently, he is the CEO of BioModeling Solutions, Inc, and holds several US and international patents.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 25 Mohammad A Alqahtani et al, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Sleep quality and daytime sleepiness in medical students of King Khalid University, Saudi Arabia Mohammad A Alqahtani, Abdulkareem F Alqahtani, Mushabab A. Alshahrani and Hasan Al-Amri King Khalid University, Saudi Arabia
Background: Sleep deprivation and symptoms related to sleep disorders are often ignored by medical fraternity; particularly the medical students.Poor sleep quality and sleep problems can have important implications on the academic and work quality of medical students. Objectives: 1. Describe the sleep quality of medical students in King Khalid University. 2. Measure the daytime sleepiness in medical students. 3. Determine the relation between sleep quality and various sleep characteristics. Methods: A cross-sectional study was done on 318 medical students selected by convenience sampling during August -September 2015. A self-administered questionnaire to obtain information regarding socio-demographic variables, indicators of sleep quality and daytime sleepiness was developed using Pittsburg Sleep Quality Index, and the Epworth sleepiness scale. Data was analyzed by using statistical software SPSS version 17.0. Descriptive statistics was reported as means and frequencies. To determine correlation between sleep characteristics and sleep quality, Karl Pearson product-moment correlation coefficient was calculated. Results were considered statistically significant at p ≤ 0.05. Results: A total of 318 students formed our study group (206 males and 112 females).The mean age was 22 years. The mean PQSI score was 6.79 indicating poor sleep quality. Mean bedtime was almost an hour past midnight (12:47am), average sleep latency was approximately 24 minutes and average sleep time was 6 hours. Sleep quality was reported as very good by 109(34.3%) students and ≥85% sleep efficiency was observed in 67.3%.Sleep onset latency more than 30 minutes was reported by16% students. Average daytime sleepiness score was high (8.2), and extreme daytime sleepiness was reported by 159 (50%) students. Correlation between daytime sleepiness, hours of sleep and sleep efficiency with quality of sleep was found significant at the 0.01 level.
Biography Abdulkareem F Alqahtani Results of this study provide an insight into the sleep pattern and sleep problems among medical students in King Khalid University, Saudi Arabia. Results reflected poor sleep quality scores coupled with good subjective sleep scores and high daytime sleepiness which indicates an existing sleep gap. The study highlights a pressing need for sensitizing medical students to proper sleep hygiene.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 26 Andrew McKinnon, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Objective sleep disturbance in Mild Cognitive Impairment is associated with alterations in the brain’s Default Mode Network Andrew McKinnon Macquarie University, Australia
his study aimed to identify Default Mode Network (DMN) functional connectivity deficits in patients with Mild Cognitive TImpairment (MCI) and sleep disturbance, relative to those with MCI and no sleep disturbance. It is a follow-up study to our prior research, which demonstrated connectivity deficits in those with self-reported sleep disturbances. The current study utilises objective sleep measurement via actigraphy to investigate. A total of 47 older adults aged 55 years and over were recruited, comprising 15 cognitively intact controls and 32 health-seeking patients.Participants underwent resting-state fMRI along with comprehensive neuropsychological, medical, psychiatric and actigraphic assessments. MCIs demonstrated significantly reduced functional connectivity relative to controls across several temporal and parietal brain regions. Relative to those without sleep disturbance, sleep-disturbed MCI participants also demonstrated significantly diminished DMN connectivity between a number of temporal and parietal regions, however the affected areas and connections differed from those revealed by the control analysis. All of these connections remained significant after controlling for antidepressant usage except one, which became borderline non-significant. Sleep disturbance in MCI is associated with DMN functional connectivity deficits in brain regions underpinning salient memory and sleep systems. These results build on our previous research and indicate that both subjective and objective sleep disturbances are associated with reductions in functional connectivty across key DMN nodes.
Biography Andrew is a graduate student undertaking the final year of a combined PhD/Master of Clinical Neuropsychology degree at Macquarie University, Sydney, Australia. He has published 4 papers in peer-reviewed journals, including 2 from his PhD.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 27 Yaron Haviv, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Adherence to oral appliance therapy in severe sleep apnea Yaron Haviv Department of Oral Medicine, Hebrew University, Hadassah School of Dental Medicine, Jerusalem, Israel
Study Objectives: Oral appliances (OA) are recommended for patients with severe obstructive sleep apnea who fail to comply with continuous positive airway pressure therapy. This study aimed to quantify adherence to OA therapy and evaluate demographics and reasons associated with non-adherence. Methods: The medical records of 52 patients with severe apnea-hypopnea index (AHI) ≥ 40, who were treated with OA after rejecting continuous positive airway pressure treatment, were studied for OA adherence. Patients were divided into two groups - users (UG) and non-users (NUG) and were followed from five months to six years (average 44.63±17.17 months) after OA delivery. Results: The mean usage time of the OA in the NUG was 10.07±8.96 months. Adherence rate was 57.7% (30/52 patients). The main factors associated with non-adherence were concerns with OA effects on teeth (22%) and its insufficient efficacy (22%). Other factors were discomfort (15%) or no need for treatment because of improved wellbeing following weight loss (15%). The overall number of interfering factors was significantly higher in the NUG (p=0.041). Nine out of 52 (17.3%) patients switched back to CPAP even though they had initially rejected using it. Conclusions: Non-adherence to OA is significantly associated with concern of its effects on teeth, the lack of efficacy and discomfort. Clinicians should closely monitor adherence patterns and assess potential interfering factors as part of the routine diagnostic work up.
Biography Yaron Haviv is working at department of Oral Medicine, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel. The Department of Oral Medicine provides clinical services in all areas of oral medicine. The Department of Oral Medicine houses a number of sub-specialty clinics, all of which provide various services to dental patients. The clinics provide dental care for patients (including handicapped patients) and emergency cases. The sub-specialty clinics, some of which are covered by Israeli health funds, provide services in oral mucosal disease, chronic orofacial pain, sensory changes in the face, salivary gland dysfunction and more.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 29 Mohammad Akram Randhawa et al., J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Thymoquinone, an active component of Nigella sativa seed, possesses antibacterial activity against anaerobic human pathogens Mohammad Akram Randhawa1, Awwad Khalaf Alenazy2, Majed Gorayan Alrowaili3 and Jamid Basha4 Department of Pharmacology1 Community Mediicne2 Surgery3 and Microbiology4 College of Medicine, Northern Border University, Arar, Saudi Arabia.
igella sativa (N. sativa) seed, known as ‘Black Seed’ has been used for many ailments in Traditional Systems of Medicine. N. sativa Ncontains many active compounds, like thymoquinone, thymohydroquinone, dithymoquinone, thymol, carvacrol, nigellimine, nigellicine, nigellidine and alpha-hederin. Thymoquinone, the most abundant active principle of N. sativa is known to kill many types of microorganisms. However, its activity against anaerobic bacteria is not well known. These bacteria reside normally in oral cavity and intestines. They become pathogenic and can cause infection in persons who have immune deficiency due to diabetes, HIV infection, anticancer chemotherapy, immune suppressants, or broad-spectrum antibacterial drugs. They can cause severe infections, including diarrhea, aspiration pneumonia and brain abscess. Only a few antibacterial drugs are effective against them, like metronidazole, which has many side effects. In the present study thymoquinone was investigated in vitro for its activity against some anaerobic human pathogens (Clostridium difficile, Clostridium perfringen, Bacteroides fragilis,and Bacteroides thetaiotaomicron) and compared with metronidazole. MICs of thymoquinone and metronidazole were determined against these anaerobes when grown in sheep blood agar and were found to be between 10-80mg/L for thymoquinone and 0.19 to 6.25mg/L for metronidazole. Results of present study support the use of black seed in treatment of diarrhea in folk medicine. Further investigations are needed for determination of synergistic effect of thymoquinone in combination with metronidazole and the activity of derivatives of thymoquinone against anaerobic infections.
Biography Mohammad Akram Randhawa graduated from King Edward Medical College, Lahore, in 1973 and completed his Masters from University of Punjab in 1977. Then after, he was deputed for postgraduate training in Clinical Pharmacology at St Bartholomew’s Hospital, London, UK. On his return to Pakistan obtained PhD degree from Quaid- i-Azam University, Islamabad. Currently, he is Professor and Head of the Department of Pharmacology, College of Medicine, Northern Border University, Arar. He has published 45 research papers in reputed scientific journals and has reviewed numerous research projects and manuscripts, mostly related to membrane transport of drugs and N. sativa (Black seed).
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 30 Gina Lizeth Castellanos Caro, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Validation of the scale “sleep apnea for quality of life index for assessing quality of life of sleep apnea hypopnea syndrome in Colombia Gina Lizeth Castellanos Caro Valle del Lili Clinic Foundation, Colombia
Introduction: The objective of this study is to realize the first phase of validation of idiomatic and cultural adaptation of the Colombian version Sleep Apnea Quality of Life Index (SAQLI) questioner of quality of life related to health, designed specifically for sleep apnea/ hypoapnea syndrome (SAHS). Materials and Methods: A protocol research was conducted in two phases of the investigation. The first is corresponding to this article in which a pilot test was performed in 30 patients with clinical suspicion or diagnosis of SAHS in two Colombian hospitals; the questionnaire was administrated to all the patients using the Spain version. An evaluation of the scale form was also provided and subjected to evaluation by an interdisciplinary committee of experts who carry out changes accordingly; finally the Colombian version was generated and subjected to a final survey. Results: The research was conducted on 43 patients, 24 for the pilot test, 13 during the final survey, and 6 patients participated in both stages. During the pilot test multiple comprehension difficulties were identified, also including several differences and omissions in translation. The committee of experts and researchers determined which linguistic changes were appropriate for adaptation, maintaining equivalence to the original English version. During the final surveys no consistent difficulties were found. A total of 32 items were modified and adapted culturally. Conclusions: The adaptation resulted in an easily understandable questionnaire within the Colombian cultural environment. The Colombian version of the SAQLI scale was generated and this study supports the steps of the validation of this questionnaire which will assess the appropriated reliability and validity for use in studies of quality of life in patients with conditions like depression and cognitive dysfunction. In conclusion, it is necessary to have appropriate tools to evaluate the quality of life for these kinds of patients.
Biography Gina Lizeth aim of the present study was to perform the first phase of validation of idiomatic and cultural adaptation of the Colombian version of the Sleep Apnea Quality of Life Index (SAQLI), a health related quality of life questionnaire specifically designed for apnea-hypopnea syndrome of the dream.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 31 Alexandru Corlateanu et al., J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
What predicts excessive daytime somnolence in sleep apnea? Alexandru Corlateanu and Victoria Sircu Department of Respiratory Medicine, State University of Medicine and Pharmacy “Nicolae Testemitanu”, Chisinau, Republic of Moldova
Objectives: The Epworth Sleepiness Scale is a simple, self-administered questionnaire which provides a measurement of the subject’s general level of daytime sleepiness. The aim of this study was to investigate the factors that can predict daytime sleepiness in patients with sleep apnea. Methods: 50 consecutive patients with suspected obstructive sleep apnea were enrolled into the study. Age, gender, anthropometric and polygraphic data were thoroughly analysed. In all subjects daily sleepiness was assessed by Epworth Sleepiness Scale. Results: The mean age of the subjects was 54.7±12.8 years, 82% males. The mean BMI was 31.9±6 kg/m2. Pearson correlation coefficient analysis demonstrates a significant positive correlation between the Epworth Sleepiness Scale and the desaturation index (r=0.31, p<0.01) and arterial hypertension (r=0.32, p<0.01). The forward stepwise regression analysis shows that the apnea hypopnea index and desaturation index are important predictors of daytime sleepiness in patients with obstructive sleep apnea which explains 40% of the Epworth Sleepiness Scale score. Conclusion: The Epworth Sleepiness Scale is a useful instrument for clinical assessment of obstructive sleep apnea. The apnea hypopnea index and desaturation index in patients with obstructive sleep apnea are independent risk factors for daytime sleepiness.
Biography Alexandru Corlateanu has completed his PhD at the age of 30 years from State Medical and Pharmaceutical University «Nicolae Testemitanu», Republic of Moldova, Chisinau. He is the Vice-Dean Faculty Medicine Nr.1 and associate professor at the Department of Respiratory Medicine/Allergology, State Medical and Pharmaceutical University «Nicolae Testemitanu», Republic of Moldova, Chisinau. He has published more than 35 papers in reputed journals and has been serving as an editorial board member of repute.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 32 Colin M Shapiro, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Biological Sleep Markers of Depression Colin M Shapiro Department of Psychiatry and Ophthalmology Director, International Sleep Clinic, Parry Sound Youth dale Child and Adolescent Sleep Centre, Toronto
epression is one of the most debilitating, widespread, costly and stigmatized illnesses of our time. Despite the importance of Ddepression, there is to date no commercially available technological support to diagnose depression and guide treatment. We have developed for the first time a system that automatically and objectively diagnoses depression by using macro and micro sleep architecture. Using these biological markers, we have achieved a detection rate of 92% for controls and 83% for depressed adults, while for children; we reached a detection rate of 100% for controls and 75% for depressed children. We anticipate that our innovative use of biological markers of depression will bring an important advance to the field and offer the much needed technological support to the diagnosis of depression. For the first time psychiatrists will have in their toolbox an easy-to-use, computerized diagnostic technique that will complement the current method of enquiry, improve diagnostic specificity and guide treatment. Currently we are investigating the possibility of using our method for predicting the road to suicide and to guide pharmacological treatment. We believe our work constitutes an important step toward the possibility of real standardization of diagnosis and in addition providing an important link in the chain leading to the elimination of stigma in psychiatry.
Biography Colin Shapiro has been involved in sleep research for over thirty years. He trained in medicine in South Africa subsequently doing his PhD in sleep physiology at the University of Edinburgh. Dr. Shapiro founded the British Sleep Society and the International Neuropsychiatry Association. Dr. Shapiro has over 300 publications in this field and a over a dozen books including a book on Forensic aspects of sleep and several books for the lay public including “Fighting Fatigue and Sleepiness”, and very recently “Insomnia in a nutshell” He also co-authored “Working the Shift” and children’s book “Who needs to sleep anyway”.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 33 Yan Ma et al., J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Comparison of wristband-based and ECG-based sleep analyses Yan Ma1, Yulin Wei2 and Chung-Kang Peng1 1Center for Dynamical Biomarkers, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA 2China-Japan Friendship Hospital, Beijing, 100029, China
owadays, the concept of sleep health management is well accepted, and consumer sleep technologies are commonly utilized Nin mobile devices including high-end wristbands and smartwatches. However, most wearable devices on the market are entertainment-oriented, and cannot generate reliable sleep assessments; their accuracy of sleep evaluation has not been studied systematically. The objective of this study is to compare the result of sleep analysis obtained by a wristband with the result from a well- accepted ECG-based sleep analysis, known as Cardiopulmonary Coupling (CPC). Huawei Metis Wristband, which implemented an algorithm based on heart rate variability developed by Nanjing Fengsheng Yongkang Software Technology Co., Ltd. (NFYST), was used. In the study, 200 subjects (98 males, 49%) were recruited, from three Chinese cities (Dongguan, Suzhou and Nanjing), with an age range of 18~45years (median age 26yr). All subjects made records for the test night, including time for bed, time to fall asleep and wake-up time in the morning. The subjects reported total sleep time (TST) ranged from 230 to 511 minutes (median TST = 410min). The data from wristband and ECG recordings were extracted and analyzed by the NFYST algorithm and CPC analysis, respectively. To investigate the accuracy of the classification obtained by wristband, six measures were calculated, and the median of six measures are stable sleep detection (83.07%); unstable sleep detection (73.14%); REM sleep detection (80.05%); stable sleep duration (87.46%); unstable sleep duration (90.02%); REM sleep duration (82.29%). The results show that the classifications obtained by wristband and CPC analysis are consistent.
Biography Chung-Kang Peng is the director of Center for Dynamical Biomarkers (DBIOM) at Beth Israel Deaconess Medical Center, a major teaching hospital of Harvard Medical School. Prof. Peng focuses on fundamental theory and novel computational algorithms for characterizing physiological states in terms of their dynamical properties. These Dynamical Biomarkers may provide more sensitive and accurate assessments of physiological states than conventional biomarkers. He has published many papers in reputed journals and has over 33 thousand citations.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 34 Zara Khan et al., J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Necrotising Fasciitis - A complication of poor glycaemic control in type 2 diabetes Zara Khan and Sujan Kumar Sen Leeds University, School of Medicine, Hull & East Yorkshire NHS Foundation Trust, UK
Introduction: This case presents the development of a rare inflammatory infection, with reported mortality rates of up to 80%. It describes the patients clinical presentation, investigations and management as well as exploring the various factors that led to this preventable condition. Case description: A 33 year old female, with a background of poorly controlled diabetes, obesity, hypercholesterolaemia and depression, presented to her general practitioner with a two week history of unresolving unilateral vulval swelling. She was referred to the gynaecology team via accident & emergency and blood tests on admission revealed elevated inflammatory markers (CRP 370, WCC 27.7, Neutrophils 23.58) along with a HbA1c of 114. Clinically, she had a raised temperature and was tachycardic; coupled with the blood results, she was deemed as being septic. She was commenced on intravenous antibiotics and had emergency debridement of the left labia, pubic region and perineum. Discussion: This case reinforces diabetes as a major risk factor for developing necrotising fasciitis and therefore highlights the importance of early diagnosis and thus low threshold for referral in such patients. The patient in this case has a 10 year history of poorly controlled diabetes which is attributed to non-compliance with medication, depressive mental state and work related stress. All of the aforementioned factors contribute to the holistic nature of a patients disease and the impact it has on their health and well being. This case teaches an important lesson of understanding the underlying factors that build up to a devastating end point.
Biography I am a foundation trainee doctor working in the Hull and East Yorkshire NHS Foundation Trust, having graduated from the University of Leeds medical school, MBChB. I am currently working in an inner city general practice in Hull, which serves a population of 10, 000 patients. I am in the process for applying for general practice specialty training.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 35 conferenceseries.com 834th Conference 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA Scientific Tracks & Abstracts (Day 2)
Sleep medicine & Integrative Medicine 2016
Page 41 Kathy sexton-Radek, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
What we learn from examining global sleep health Kathy sexton-Radek Elmhurst College, USA
he utility of salvia collection of Melatonin in the measurement of Circadian Rhythms. This oral presentation will address the Tcurrent use of salvia collection of Melatonin. The sensitivities and specificities will be reported from a number of laboratories. The presentation will then describe the various research aims and projects using the salvia collection of Melatonin measure. Results from the author’s pilot study will be presented.
Biography Kathy sexton-Radek has received her doctorate of Philosophy degree from Illinois institute of technology in 1989 and interned at Rush Medical University 1988-1989 in sleep Medicine, Behavioural Medicine, Geriatric Medicine and Health Psychology rotations. Currently, she is working as professor in Elmhurst College, Psychology Department since 1988. She received her board certification in Behavioural Sleep Medicine. She completed two-years –Doctorate certificate program in Clinical Psychopharmacology which included a yearlong preceptor ship with psychiatry and pulmonary rotation.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 43 Alexandru Corlateanu et al., J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Risk factors for severity of obstructive sleep apnea Alexandru Corlateanu and Victoria Sircu Department of Respiratory Medicine, State University of Medicine and Pharmacy “Nicolae Testemitanu”, Chisinau, Republic of Moldova
Objectives: Patients with obstructive sleep apnoea syndrome are at increased risk for a broad range of cardiovascular (systemic hypertension, pulmonary arterial hypertension, coronary artery disease, cardiac arrhythmias, heart failure, stroke and motor vehicle crashes) and metabolic comorbidities (insulin resistance, diabetes, and metabolic syndrome). The aim of this study was to evaluate the relationship between comorbidities and severity of obstructive sleep apnoea syndrome. Methods: 50 consecutive patients with suspected obstructive sleep apnea were enrolled into the study. Age, gender, anthropometric, overnight cardio-respiratory monitoring data and comorbidities were analysed. Results: The mean age of the subjects was 54.7±12.8 years, 82% males and 18% females. The mean BMI was 31.9±6 kg/m2. Spearman correlation coefficient analysis demonstrates a significant positive correlation between the hypertension and the apnea hypopnea index (r=0.55, p<0.05), the desaturation index (r=0.6, p<0.05). Obesity and diabetes mellitus correlated weaker with these indexes. The forward stepwise regression analysis shows that the hypertension and diabetes mellitus are important predictors of severity of obstructive sleep apnea which explains 40% of the apnea hypopnea index. Conclusion: The hypertension and diabetes mellitus in patients with obstructive sleep apnea are independent risk factors for severity of obstructive sleep apnea.
Biography Alexandru Corlateanu has completed his PhD at the age of 30 years from State Medical and Pharmaceutical University «Nicolae Testemitanu», Republic of Moldova, Chisinau. He is the Vice-Dean Faculty Medicine Nr.1 and associate professor at the Department of Respiratory Medicine/Allergology, State Medical and Pharmaceutical University Nicolae Testemitanu, Republic of Moldova, Chisinau. He has published more than 35 papers in reputed journals and has been serving as an editorial board member of repute.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 44 Masako Okawa, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Circadian rhythm sleep disorders: Characteristics and entrainment pathology in delayed sleep phase and non-24 sleep wake syndrome Masako Okawa Department of Psychiatry, Department of Somnology, Tokyo Medical University, Japan
he sleep–wake rhythm in humans is regulated by the circadian timing system, and disorders of this system are known as circadian Trhythm sleep disorders, which can have multiple etiologies but result in maladjustment of the biological clock with respect to the environment. This presentation will focus on a clinical review of delayed sleep phase syndrome and non-24-h sleep wake syndrome, which are representative syndromes in CRDS. These syndromes seem to be common and under-recognized in society, not only in the blind, but also typically emerging during adolescence. Both types of syndrome can appear alternatively or intermittently in an individual patient. Psychiatric problems are also common in both syndromes. DSPS and non-24 could share common circadian rhythm pathology in terms of clinical process and biological evidence. The biological basis is characterized by a longer sleep period, a prolonged interval from the body temperature nadir-to-sleep offset, a relatively advanced temperature rhythm, lower sleep propensity after total sleep deprivation, and higher sensitivity to light than in normal controls. There are multiple lines of evidence suggesting dysfunctions at the behavioral, physiological and genetic levels. Treatment procedures and prevention of the syndromes require further attention using behavioral, environmental, and psychiatric approaches, since an increasing number of patients in modern society suffer from these disorders.
Biography Masako Okawa completed her Postdoctoral Research Fellow in Sleep Laboratory Baylor College of Medicine, Houston, Texas, USA in 1975, MD in Gunma University School of Medicine, Maebashi in 1967. She worked as Senior Staff Associate in Department of Clinical Neurophysiology, Goteborg University, Sweden from 1979. She held the position as Director, Department of Psychophysiology National Institute of Mental Health, National Center for Neurology and Psychiatry, Ichikawa from 1991 & Japan Foundation for Neuroscience and Mental Health, Tokyo in 2013. She worked as Professor of Sleep Medicine, Shiga University of Medical Science, Otsu & Somnology, Tokyo Medical University, Tokyo in 2006 and 2013 respectively. In her career she was awarded with Baelz Prize for the research on “Biological Rhythms of Elderly Patients with Dementia and Paul Janssen Prize in 1989 and 2005 respectively.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 46 Norman S Miller, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Painful and Pathological Medications Norman S Miller Health Advocates PLLC, USA
espite the widespread prescribing of opioid medications for the treatment of chronic pain there is little or no evidence for its Defficacy. In fact, the studies show that long-term prescribing of opioid medications leads to significant morbidity and mortality. The Controlled Substance Laws define prescription opioid medication as dangerous and addicting medications. Despite the classification and scheduling of opioid medication, their prescribing continues to be widespread and adverse. Of central importance is there are few studies of the addicting properties that drive the high rates of prescribing and adverse consequences. It is a myth that most people treated with opioids never become addicted and addiction does not develop if you are prescribing for pain. Why are opioid medications prescribed in large quantities and high frequency when there is little or no proven efficacy for their therapeutic value? Why are opioids the most commonly prescribed medication in the United States for the past decades when the adverse consequences continue to grow? Why does the medical profession continue to prescribe opioid medications that result in increased pain and increased disability? This article summarizes the inherent addictive pharmacologic properties that are the impetus and basis for America’s current opioid epidemic.
Biography Norman S Miller, MD, JD, PLLC, is the Medical Director, Detoxification and Residential Programs, Bear River Health at Walloon Lake, and the President, Health Advocates PLLC. Dr. Norman Miller is a psychiatrist in East Lansing, Michigan and is affiliated with multiple hospitals in the area, including Covenant Medical Center and DMC Detroit Receiving Hospital. He received his medical degree from Howard University College of Medicine and has been in practice for 41 years. He is one of 6 doctors at Covenant Medical Center and one of 26 at DMC Detroit Receiving Hospital who specialize in Psychiatry.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 47 Colin M Shapiro, J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
The Sleep-Mood Interfact Colin M Shapiro Department of Psychiatry and Ophthalmology Director, International Sleep Clinic, Parry Sound Youth dale Child and Adolescent Sleep Centre, Toronto, Canada
epression and sleep disorders are closely linked. Depression results in poor quality of life and increases the risk of suicide. DUntreated sleep disorders lead to early-onset dementia and worsen outcome in medical illness. Further, untreated sleep disorders substantially increase the risk of developing new onset depression, promotes recurrence of remitted depression and gives rise to treatment-resistant depression. Notably, poor sleep is a risk factor for suicide, even in the absence of depression. Primary care physicians have a poor track record of detecting depression and screening for sleep disorders. This unmet medical need underscores the requirement for novel diagnostic technology employing biological markers to detect depression and sleep disorders. Such innovative techniques have recently been unveiled, and their benefits include: 1. The ability to simultaneously screen for depression and sleep disorders; 2. The convenience of in-home diagnostic testing; 3. Cloud-based computerized algorithms to ensure quick dissemination of test results; 4. The ability to test several individuals simultaneously thereby avoiding long wait-lists; and, 5. The low cost of testing with this technology is paramount given the dwindling healthcare resources. This technology represents a promising development to improve the detection of depression and sleep disorders across all age-groups.
Biography Dr. Colin Shapiro has been involved in sleep research for over thirty years. He trained in medicine in South Africa subsequently doing his PhD in sleep physiology at the University of Edinburgh. Dr. Shapiro founded the British Sleep Society and the International Neuropsychiatry Association. Dr. Shapiro has over 300 publications in this field and a over a dozen books including a book on Forensic aspects of sleep and several books for the lay public including “Fighting Fatigue and Sleepiness”, and very recently “Insomnia in a nutshell” He also co-authored “Working the Shift” and children’s book “Who needs to sleep anyway”.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
Page 48 Yap Jing Yi et al., J Sleep Disord Ther 2015, 5:6(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2167-0277.C1.005 2nd International Conference on Sleep Disorders, Medicine & Integrative Medicine November 28-30, 2016 Atlanta, USA
Sleep disturbance in palliative care patients Yap Jing Yi and J Y YAP Changi General Hospital, Singapore
Introduction: Sleep disturbance is highly prevalent among palliative patients, estimated to affect up to 75% of patients with advanced cancers. Sleep disturbance can have a huge impact on the quality of life of patients, as well as worsen other symptoms. Method: We examine 3 of our patients with sleep disturbance who have been selected for the case study. The 1st case is a 65-year-old gentleman with ESRF, the 2nd patient is a 40-year-old lady with advanced breast cancer and an underlying sleep disorder, and the 3rd is a 78-year-old gentleman with COPD and refractory breathlessness. Result: Sleep disturbance is largely attributable to a large number of factors such as environment, emotional, physiological and physical causes. However, there is a lack of standard assessment tool and treatment guideline for palliative patients with sleep disturbance. Conclusion: Despite the high incidence of sleep disturbance among palliative cancers, this is often poorly addressed. There is also a lack of referral to sleep specialists, hence resulting in a underdiagnosis of a concurrent underlying sleep disorder. If more sleep disturbances can be identified earlier in palliative patients, interventions can be initiated early, for example, in the clinic setting which can improve their symptoms greatly.
Biography Yap Jing Yi graduated from University of Leicester, UK in 2010, before completing her housemanship in UK. She is currently working in Singapore and has a keen interest in research and palliative medicine.
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J Sleep Disord Ther 2015 Sleep medicine & Integrative Medicine 2016 Volume 5, Issue 6(Suppl) ISSN: 2167-0277, JSDT an open access journal November 28-30, 2016
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