Baseline Chronic Comorbidity and Mortality in Laboratory-Confirmed
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EFFECTIVE NEBRASKA DEPARTMENT of 01/01/2017 HEALTH and HUMAN SERVICES 173 NAC 1 I TITLE 173 COMMUNICABLE DISEASES CHAPTER 1
EFFECTIVE NEBRASKA DEPARTMENT OF 01/01/2017 HEALTH AND HUMAN SERVICES 173 NAC 1 TITLE 173 COMMUNICABLE DISEASES CHAPTER 1 REPORTING AND CONTROL OF COMMUNICABLE DISEASES TABLE OF CONTENTS SECTION SUBJECT PAGE 1-001 SCOPE AND AUTHORITY 1 1-002 DEFINITIONS 1 1-003 WHO MUST REPORT 2 1-003.01 Healthcare Providers (Physicians and Hospitals) 2 1-003.01A Reporting by PA’s and APRN’s 2 1-003.01B Reporting by Laboratories in lieu of Physicians 3 1-003.01C Reporting by Healthcare Facilities in lieu of Physicians for 3 Healthcare Associated Infections (HAIs) 1-003.02 Laboratories 3 1-003.02A Electronic Ordering of Laboratory Tests 3 1-004 REPORTABLE DISEASES, POISONINGS, AND ORGANISMS: 3 LISTS AND FREQUENCY OF REPORTS 1-004.01 Immediate Reports 4 1-004.01A List of Diseases, Poisonings, and Organisms 4 1-004.01B Clusters, Outbreaks, or Unusual Events, Including Possible 5 Bioterroristic Attacks 1-004.02 Reports Within Seven Days – List of Reportable Diseases, 5 Poisonings, and Organisms 1-004.03 Reporting of Antimicrobial Susceptibility 8 1-004.04 New or Emerging Diseases and Other Syndromes and Exposures – 8 Reporting and Submissions 1-004.04A Criteria 8 1-004.04B Surveillance Mechanism 8 1-004.05 Sexually Transmitted Diseases 9 1-004.06 Healthcare Associated Infections 9 1-005 METHODS OF REPORTING 9 1-005.01 Health Care Providers 9 1-005.01A Immediate Reports of Diseases, Poisonings, and Organisms 9 1-005.01B Immediate Reports of Clusters, Outbreaks, or Unusual Events, 9 Including Possible Bioterroristic Attacks i EFFECTIVE NEBRASKA DEPARTMENT OF -
The Repurposing Drugs in Oncology Database
ReDO_DB: the repurposing drugs in oncology database Pan Pantziarka1,2, Ciska Verbaanderd1,3, Vidula Sukhatme4, Rica Capistrano I1, Sergio Crispino1, Bishal Gyawali1,5, Ilse Rooman1,6, An MT Van Nuffel1, Lydie Meheus1, Vikas P Sukhatme4,7 and Gauthier Bouche1 1The Anticancer Fund, Brussels, 1853 Strombeek-Bever, Belgium 2The George Pantziarka TP53 Trust, London, UK 3Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium 4GlobalCures Inc., Newton, MA 02459 USA 5Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115 USA 6Oncology Research Centre, Vrije Universiteit Brussel, Brussels, Belgium 7Emory University School of Medicine, Atlanta, GA 30322 USA Correspondence to: Pan Pantziarka. Email: [email protected] Abstract Repurposing is a drug development strategy that seeks to use existing medications for new indications. In oncology, there is an increased level of activity looking at the use of non-cancer drugs as possible cancer treatments. The Repurposing Drugs in Oncology (ReDO) project has used a literature-based approach to identify licensed non-cancer drugs with published evidence of anticancer activity. Data from 268 drugs have been included in a database (ReDO_DB) developed by the ReDO project. Summary results are outlined and an assessment Research of clinical trial activity also described. The database has been made available as an online open-access resource (http://www.redo-project. org/db/). Keywords: drug repurposing, repositioning, ReDO project, cancer drugs, online database Published: 06/12/2018 Received: 27/09/2018 ecancer 2018, 12:886 https://doi.org/10.3332/ecancer.2018.886 Copyright: © the authors; licensee ecancermedicalscience. -
C Lif I I I I C Lif I I I I California Immunization Requirements
ClifCaliforn ia IiiImmunization Requirements for School & Child Care Entry Jennifer Sterling San Diego Immunization Partnership www.sdiz.org CtCounty of San Diego, HlthHealth and Human SiServices Agency Immunization Partnership Training Objectives At the end of this training, you will be able to: • List the immunization requirements for child care entry. • Identify acceptable forms of personal immunization records. • Correctly complete the California School Immunization Record (CSIR)/Blue Card. • Create a management system for conditional entrants and exemptions. Why Do We Need Immunizations? • Protect children and families • Prevent illnesses which can cause death and disability • Protect the health of others in the community • Good Public Health Practice Spread of Disease read of Disease –– a a cough, cough, sneezesneeze, or handshake away, or handshake away Vaccine Preventable Diseases in San Diego County Pertussis (Whooping Cough) >604 cases so far in 2010! The worst epidemic in 55 years. • Adults spreading sickness to babies. Nine babies under 3 months of age have died in California this year. • To preven t the sprea d o f Per tuss is, ge t the TDAP vacci ne! Chickenpox • 2009: 69 cases in 10 school districts • 2010: 10 cases in 2 school districts Measles • 2010: Three measles cases in Carlsbad, nine children quarantined • Measles outbreak in San Diego during January and February 2008‐first measles outbreak since 1991! ‐12 cases in 2008 ‐71 peopl e quarantine d Polio is still epidemic in 4 countries! Pertussis – Nearly 50% of the time, infants are infected by their parents Prevention of Disease – SimpleSimple!! Immunizations help prevent the spread of communicable diseases. Cover mouth (w/arm) when coughing or sneezing. -
European Conference on Rare Diseases
EUROPEAN CONFERENCE ON RARE DISEASES Luxembourg 21-22 June 2005 EUROPEAN CONFERENCE ON RARE DISEASES Copyright 2005 © Eurordis For more information: www.eurordis.org Webcast of the conference and abstracts: www.rare-luxembourg2005.org TABLE OF CONTENT_3 ------------------------------------------------- ACKNOWLEDGEMENTS AND CREDITS A specialised clinic for Rare Diseases : the RD TABLE OF CONTENTS Outpatient’s Clinic (RDOC) in Italy …………… 48 ------------------------------------------------- ------------------------------------------------- 4 / RARE, BUT EXISTING The organisers particularly wish to thank ACKNOWLEDGEMENTS AND CREDITS 4.1 No code, no name, no existence …………… 49 ------------------------------------------------- the following persons/organisations/companies 4.2 Why do we need to code rare diseases? … 50 PROGRAMME COMMITTEE for their role : ------------------------------------------------- Members of the Programme Committee ……… 6 5 / RESEARCH AND CARE Conference Programme …………………………… 7 …… HER ROYAL HIGHNESS THE GRAND DUCHESS OF LUXEMBOURG Key features of the conference …………………… 12 5.1 Research for Rare Diseases in the EU 54 • Participants ……………………………………… 12 5.2 Fighting the fragmentation of research …… 55 A multi-disciplinary approach ………………… 55 THE EUROPEAN COMMISSION Funding of the conference ……………………… 14 Transfer of academic research towards • ------------------------------------------------- industrial development ………………………… 60 THE GOVERNEMENT OF LUXEMBOURG Speakers ……………………………………………… 16 Strengthening cooperation between academia -
Diseases Transmitted Through the Food Supply
DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Diseases Transmitted through the Food Supply AGENCY: Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS). ACTION: Notice of annual update of list of infectious and communicable diseases that are transmitted through handling the food supply and the methods by which such diseases are transmitted. SUMMARY: Section 103 (d) of the Americans with Disabilities Act of 1990, Public Law 101–336, requires the Secretary to publish a list of infectious and communicable diseases that are transmitted through handling the food supply and to review and update the list annually. The Centers for Disease Control and Prevention (CDC) published a final list on August 16, 1991 (56 FR40897) and updates on September 8, 1992 (57 FR 40917); January 13, 1994 (59 FR 1949); August 15, 1996 (61 FR 42426); September 22, 1997 (62 FR 49518–9); September 15, 1998 (63 FR 49359); September 21, 1999 (64 FR 51127); September 27, 2000 (65 FR 58088); September 10, 2001 (66 FR 47030); September 27, 2002 (67 FR 61109); September 26, 2006 (71 FR 56152); November 17, 2008 (73 FR 67871); and November 29, 2009 (74 FR 61151). The final list has been reviewed in light of new information and has been revised as set forth below. DATES: Effective Date: January 31, 2014. FOR FURTHER INFORMATION CONTACT: Dr. Art Liang, Division of Foodborne Waterborne and Environment Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, NE., Mailstop G–24, Atlanta, Georgia 30333. -
Summary of Product Characteristics 1. Name Of
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE MEDICINAL PRODUCT Iloprost Pharmamentum 50 micrograms/0.5 ml concentrate for solution for infusion 2. QUALITATIVE AND QUANTITATIVE COMPOSITION 0.5 ml of aqueous solution contains 67 micrograms of Iloprost trometamol (equivalent to 50 micrograms of iloprost). For a full list of excipients, see section 6.1. 3. PHARMACEUTICAL FORM Concentrate for solution for infusion. Clear, colourless solution with no visible particles. 4. CLINICAL PARTICULARS 4.1 Therapeutic indications Treatment of advanced thromboangiitis obliterans (Buerger’s disease), with severe circulation disturbances, in cases where revasculariation is not indicated. 4.2 Posology and method of administration The treatment with Iloprost Pharmamentum should be performed under strict monitoring in hospitals or clinics that have suitable equipment. Before initiating the treatment in women, pregnancy must be ruled out. Iloprost Pharmamentum is administered after dilution, as described in section 6.6 “Special precautions for disposal”, as an intravenous infusion, for a period of 6 hours/day, through a peripheral vein or a central catheter into a vein. The dose will be adjusted according to the individual tolerability within a dosage range of 0.5 to 2.0 ng iloprost/kg of body weight/min. The solution for infusion should be prepared daily to ensure its sterility. The content of the ampoule and solvent must be completely mixed. Blood pressure and heart rate should be monitored at the beginning of the infusion and after each dose increase. During the first 2 to 3 days the dose tolerated by the patient will be determined. In order to do this, the treatment should start with an infusion rate that supplies a dose of 0.5 ng/kg/min, for 30 minutes. -
Microtubule Regulation in Cystic Fibrosis Pathophysiology
MICROTUBULE REGULATION IN CYSTIC FIBROSIS PATHOPHYSIOLOGY By: SHARON MARIE RYMUT Submitted in partial fulfillment of the requirements For the degree of Doctor of Philosophy Dissertation Advisor: Dr. Thomas J Kelley Department of Pharmacology CASE WESTERN RESERVE UNIVERSITY August 2015 CASE WESTERN RESERVE UNIVERSITY SCHOOL OF GRADUATE STUDIES We hereby approve the thesis/ dissertation of Sharon Marie Rymut candidate for the Doctor of Philosophy degree* Dissertation Advisor: Thomas J Kelley Committee Chair: Paul N MacDonald Committee Member: Ruth E Siegel Committee Member: Craig A Hodges Committee Member: Danny Manor Committee Member: Rebecca J Darrah Date of Defense: April 29, 2015 * We also certify that written approval has been obtained for any proprietary material contained therein. ii Dedication There are five chapters in this dissertation. To Mom, Dad, Joe, Marie and Susan, I dedicate one chapter to each of you. You can fight about which chapter you want later. iii Table of Contents Table of Contents................................................................................................................iv List of Tables .................................................................................................................... vii List of Figures .................................................................................................................. viii Acknowledgements ............................................................................................................. x List of Abbreviations ....................................................................................................... -
Federal Register/Vol. 82, No. 214/Tuesday
Federal Register / Vol. 82, No. 214 / Tuesday, November 7, 2017 / Rules and Regulations 51567 range of age and educational levels and lead to prophylactic screening, SUPPLEMENTARY INFORMATION: have no prior experience with the test confirmatory procedures, or treatments I. Statutory Background or its manufacturer. These factors shall that may incur morbidity or mortality to be well defined in the inclusion and the patient; Section 510(k) of the Federal Food, exclusion criteria. (iii) Assessing the presence of genetic Drug, and Cosmetic Act (the FD&C Act) (ii) All sources of bias must be variants that impact the metabolism, (21 U.S.C. 360(k)) and the implementing predefined and accounted for in the exposure, response, risk of adverse regulations, 21 CFR part 807 subpart E, study results with regard to both events, dosing, or mechanisms of require persons who intend to market a responders and non-responders. prescription or over-the-counter device to submit and obtain FDA (iii) The testing must follow a format medications; or clearance of a premarket notification where users have limited time to (iv) Assessing the presence of (510(k)) containing information that complete the studies (such as an onsite deterministic autosomal dominant allows FDA to determine whether the survey format and a one-time visit with variants. new device is ‘‘substantially equivalent’’ a cap on the maximum amount of time within the meaning of section 513(i) of Dated: November 1, 2017. that a participant has to complete the the FD&C Act (21 U.S.C. 360c(i)) to a tests). Lauren Silvis, legally marketed device that does not (iv) Users must be randomly assigned Chief of Staff. -
LIST of OCCUPATIONAL DISEASES (Revised 2010)
LIST OF OCCUPATIONAL DISEASES (revised 2010) Identification and recognition of occupational diseases: Criteria for incorporating diseases in the ILO list of occupational diseases Occupational Safety and Health Series, No. 74 List of occupational diseases (revised 2010) Identification and recognition of occupational diseases: Criteria for incorporating diseases in the ILO list of occupational diseases INTERNATIONAL LABOUR OFFICE • GENEVA Copyright © International Labour Organization 2010 First published 2010 Publications of the International Labour Office enjoy copyright under Protocol 2 of the Universal Copyright Convention. Nevertheless, short excerpts from them may be reproduced without authorization, on condition that the source is indicated. For rights of reproduction or translation, application should be made to ILO Publications (Rights and Permissions), International Labour Office, CH-1211 Geneva 22, Switzerland, or by email: pubdroit@ ilo.org. The International Labour Office welcomes such applications. Libraries, institutions and other users registered with reproduction rights organizations may make copies in accordance with the licences issued to them for this purpose. Visit www.ifrro.org to find the reproduction rights organization in your country. ILO List of occupational diseases (revised 2010). Identification and recognition of occupational diseases: Criteria for incorporating diseases in the ILO list of occupational diseases Geneva, International Labour Office, 2010 (Occupational Safety and Health Series, No. 74) occupational disease / definition. 13.04.3 ISBN 978-92-2-123795-2 ISSN 0078-3129 Also available in French: Liste des maladies professionnelles (révisée en 2010): Identification et reconnaissance des maladies professionnelles: critères pour incorporer des maladies dans la liste des maladies professionnelles de l’OIT (ISBN 978-92-2-223795-1, ISSN 0250-412x), Geneva, 2010, and in Spanish: Lista de enfermedades profesionales (revisada en 2010). -
ICD-10 International Statistical Classification of Diseases and Related Health Problems
ICD-10 International Statistical Classification of Diseases and Related Health Problems 10th Revision Volume 2 Instruction manual 2010 Edition WHO Library Cataloguing-in-Publication Data International statistical classification of diseases and related health problems. - 10th revision, edition 2010. 3 v. Contents: v. 1. Tabular list – v. 2. Instruction manual – v. 3. Alphabetical index. 1.Diseases - classification. 2.Classification. 3.Manuals. I.World Health Organization. II.ICD-10. ISBN 978 92 4 154834 2 (NLM classification: WB 15) © World Health Organization 2011 All rights reserved. Publications of the World Health Organization are available on the WHO web site (www.who.int) or can be purchased from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press through the WHO web site (http://www.who.int/about/licensing/copyright_form). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. -
FAQ REGARDING DISEASE REPORTING in MONTANA | Rev
Disease Reporting in Montana: Frequently Asked Questions Title 50 Section 1-202 of the Montana Code Annotated (MCA) outlines the general powers and duties of the Montana Department of Public Health & Human Services (DPHHS). The three primary duties that serve as the foundation for disease reporting in Montana state that DPHHS shall: • Study conditions affecting the citizens of the state by making use of birth, death, and sickness records; • Make investigations, disseminate information, and make recommendations for control of diseases and improvement of public health to persons, groups, or the public; and • Adopt and enforce rules regarding the reporting and control of communicable diseases. In order to meet these obligations, DPHHS works closely with local health jurisdictions to collect and analyze disease reports. Although anyone may report a case of communicable disease, such reports are submitted primarily by health care providers and laboratories. The Administrative Rules of Montana (ARM), Title 37, Chapter 114, Communicable Disease Control, outline the rules for communicable disease control, including disease reporting. Communicable disease surveillance is defined as the ongoing collection, analysis, interpretation, and dissemination of disease data. Accurate and timely disease reporting is the foundation of an effective surveillance program, which is key to applying effective public health interventions to mitigate the impact of disease. What diseases are reportable? A list of reportable diseases is maintained in ARM 37.114.203. The list continues to evolve and is consistent with the Council of State and Territorial Epidemiologists (CSTE) list of Nationally Notifiable Diseases maintained by the Centers for Disease Control and Prevention (CDC). In addition to the named conditions on the list, any occurrence of a case/cases of communicable disease in the 20th edition of the Control of Communicable Diseases Manual with a frequency in excess of normal expectancy or any unusual incident of unexplained illness or death in a human or animal should be reported. -
House of Representatives
House of Representatives General Assembly File No. 45 February Session, 2004 House Bill No. 5201 House of Representatives, March 15, 2004 The Committee on Insurance and Real Estate reported through REP. OREFICE of the 37th Dist., Chairperson of the Committee on the part of the House, that the bill ought to pass. AN ACT CONCERNING NEWBORN SCREENING AND MEDICALLY NECESSARY NUTRITIONAL FORMULA FOR CYSTIC FIBROSIS. Be it enacted by the Senate and House of Representatives in General Assembly convened: 1 Section 1. Section 38a-492c of the general statutes is repealed and the 2 following is substituted in lieu thereof (Effective October 1, 2004): 3 (a) For purposes of this section: 4 (1) "Inherited metabolic disease" means a disease for which 5 newborn screening is required under section 19a-55, as amended by 6 this act. 7 (2) "Low protein modified food product" means a product 8 formulated to have less than one gram of protein per serving and 9 intended for the dietary treatment of an inherited metabolic disease 10 under the direction of a physician. 11 (3) "Amino acid modified preparation" means a product intended HB5201 / File No. 45 1 HB5201 File No. 45 12 for the dietary treatment of an inherited metabolic disease under the 13 direction of a physician. 14 (4) "Specialized formula" means a nutritional formula for children 15 up to age three that is exempt from the general requirements for 16 nutritional labeling under the statutory and regulatory guidelines of 17 the federal Food and Drug Administration and is intended for use 18 solely under medical supervision in the dietary management of 19 specific diseases.