DOCSLIB.ORG

National Horizon Scanning Centre

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
National Horizon Scanning Centre National Horizon Scanning Centre Larotaxel for advanced pancreatic cancer: recurrent and/or metastatic - second line April 2008 This technology summary is based on information available at the time of research and a limited literature search. It is not intended to be a definitive statement on the safety, efficacy or effectiveness of the health technology covered and should not be used for commercial purposes. The National Horizon Scanning Centre Research Programme is part of the National Institute for Health Research April 2008 National Horizon Scanning Centre News on emerging technologies in healthcare Larotaxel for advanced pancreatic cancer: recurrent and/or metastatic - second line Target group • Pancreatic cancer: advanced, recurrent and/or metastatic – second line. Technology description Larotaxel is a third-generation taxane, which binds to tubulin, halting mitosis and causing cell death. Larotaxel has a lower affinity for P-glycoprotein than docetaxel, which may overcome tumour resistance to taxanes. Larotaxel is administered at 90 mg/m2 by intravenous infusion (iv) every 3 weeks. Larotaxel is in phase III clinical trials for bladder cancer, phase II trials for HER2- positive advanced breast cancer (in combination with trastuzumab) and phase I/II trial for advanced breast cancer (in combination with capecitabine). Innovation and/or advantages Larotaxel may improve survival in this patient group, which has a very poor prognosis. Developer Sanofi-Aventis. Availability, launch or marketing dates, and licensing plans: In phase III clinical trials. NHS or Government priority area: This topic relates to the NHS Cancer Plan (2000). Relevant guidance • NICE technology appraisal. Gemcitabine for the treatment of pancreatic cancer. 20011. • Proposed NICE technology appraisal – out for consultation. Capecitabine for advanced pancreatic cancer. • Pancreatic Section of the British Society of Gastroenterology, Pancreatic Society of Great Britain and Ireland, Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, Royal College of Pathologists, Special Interest Group for Gastro- Intestinal Radiology. Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas. 20052. Clinical need and burden of disease Pancreatic cancer is the eighth most common cancer in the UK and the sixth most common cause of death from cancer3. There were 6,655 patients diagnosed with pancreatic cancer in 2004 in England and Wales4, and 6,462 registered deaths from pancreatic cancer in 20055. The one-year and five-year survival rates for people diagnosed in 2001 were 12-13% and 2% respectively6. An estimated 80% of patients have locally advanced or metastatic disease at diagnosis. The proportion who receive first-line chemotherapy is unknown. Existing comparators and treatments • Gemcitabine iv 2 April 2008 National Horizon Scanning Centre News on emerging technologies in healthcare • 5-fluorouracil iv • Capecitabine - unlicensed Efficacy and safety Trial code NCT004172097 PAPRIKA: Larotaxel vs 5-FU; phase III. Sponsor Sanofi-Aventis Status Ongoing Location USA, Europe, UK. Design Randomised, open label. Participants in trial n=400; adults; advanced pancreatic cancer, non-operable in a curative intent, locally recurrent or metastatic; previously treated with gemcitabine hydrochloride. Randomised to larotaxel 90 mg/m2 iv every 3 weeks vs 5-FU iv every 3 weeks. Primary outcome Overall survival (OS) Secondary outcomes Progression free survival (PFS); overall response rate (ORR); clinical benefit based on measurement of tumour related symptoms; safety and efficacy. Expected reporting date Study started in December 2006. Estimated cost and cost impact The cost of larotaxel has not been determined. Potential or intended impact – speculative Patients Reduced morbidity ; Reduced mortality or increased Improved quality of life for patients survival and/or carers Quicker, earlier or more accurate Other: None identified diagnosis or identification of disease Services ; Increased use – therapy Service reorganisation required Staff or training required administration, management of adverse effects Decreased use Other: Non identified Costs Increased unit cost compared to Increased costs: more patients Increased costs: capital alternative coming for treatment investment needed ; New costs: drug and Savings: Other: administration costs References 1 National Institute for Health and Clinical Excellence (NICE). Pancreatic Cancer – Gemcitabine. Technology appraisal 25. May 2001 2 Pancreatic Section of the British Society of Gastroenterology, Pancreatic Society of Great Britain and Ireland, Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, Royal College of Pathologists, Special Interest Group for Gastro-Intestinal Radiology. Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas. Gut 2005;54:1-16 3 April 2008 National Horizon Scanning Centre News on emerging technologies in healthcare 3 Ward S, Morris E, Bansback N et al. A rapid and systematic review of the clinical effectiveness and cost- effectiveness of gemcitabine for the treatment of pancreatic cancer. Health Technology Assessment 2001;Vol. 5:No. 24. Available at: http://www.ncchta.org/execsumm/summ524.shtml (accessed 8.2.08). 4 Cancer Research UK, Cancer incidence stats. (accessed 8.2.08). http://info.cancerresearchuk.org/cancerstats/incidence/site/?a=5441 5 Cancer Research UK, Cancer mortality stats. (accessed 8.2.08). http://info.cancerresearchuk.org/cancerstats/mortality/siteandUKcountry/?a=5441 6 Cancer Research UK, Cancer survival stats. (accessed 8.2.08). http://info.cancerresearchuk.org/cancerstats/survival/siteandsex/?a=5441 7 Clinical trials. Larotaxel compared to continuous administration of 5-FU in advanced pancreatic cancer patients previously treated with a gemcitabine-containing regimen (PAPRIKA). Available at: http://clinicaltrials.gov/ct2/show/NCT00417209?term=NCT00417209&rank=1 (Accessed 25/4/08). The National Institute for Health Research National Horizon Scanning Centre Research Programme is funded by the Department of Health. The views expressed in this publication are those of the author and not necessarily those of the NHS, the NIHR or the Department of Health The National Horizon Scanning Centre, Department of Public Health and Epidemiology University of Birmingham, Edgbaston, Birmingham, B15 2TT, England Tel: +44 (0)121 414 7831 Fax +44 (0)121 414 2269 www.pcpoh.bham.ac.uk/publichealth/horizon 4 .
Load more

Recommended publications
  • Tanibirumab (CUI C3490677) Add to Cart
    5/17/2018 NCI Metathesaurus Contains Exact Match Begins With Name Code Property Relationship Source ALL Advanced Search NCIm Version: 201706 Version 2.8 (using LexEVS 6.5) Home | NCIt Hierarchy | Sources | Help Suggest changes to this concept Tanibirumab (CUI C3490677) Add to Cart Table of Contents Terms & Properties Synonym Details Relationships By Source Terms & Properties Concept Unique Identifier (CUI): C3490677 NCI Thesaurus Code: C102877 (see NCI Thesaurus info) Semantic Type: Immunologic Factor Semantic Type: Amino Acid, Peptide, or Protein Semantic Type: Pharmacologic Substance NCIt Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed in many tumors and is correlated to tumor progression. PDQ Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor
    [Show full text]
  • Supportive Oncology
    Utku_v1_A4_book_01_2011 14/12/2011 15:10 Page 228 Supportive Oncology The End of Cytotoxics? Nalân Utku Private Lecturer, Institute for Medical Immunology, Charité University Hospital Berlin Abstract Cytotoxic drugs were the first form of cancer chemotherapy to be established, but they can have quite severe side effects. Cytotoxics attack all rapidly dividing cells, including healthy cells and cancer cells. They can therefore cause side effects such as loss of hair, damage to the skin and mucosa, and damage to bone marrow, affecting the immune system. For this reason, the focus of some cancer research has moved from cytotoxics to targeted therapeutics, including monoclonal antibodies. Monoclonal antibodies can be very effective in patients who express the appropriate target; however, not all patients do, and some develop resistance. Monoclonal antibodies, like other biologicals, are also very costly. All is not lost for cytotoxics. Because they have been around for so long, there is an abundance of data on their modes of action. Based on these data, researchers have developed newer cytotoxics that are more effective and have fewer side effects, and approaches that deliver cytotoxics more safely or target them to tumours. Keywords Antigens, cancer, cytotoxics, drug delivery, monoclonal antibodies, targeting Disclosure: Nalân Utku is Managing Director of CellAct Pharma GmbH, a biotech company focused on the development of innovative therapeutics. Received: 5 May 2011 Accepted: 6 September 2011 Citation: European Oncology & Haematology, 2011;7(4):228–33 DOI: 10.17925/EOH.2011.07.04.228 Correspondence: Nalân Utku, Institut für Medizinische Immunologie, Charité Universitätsmedizin Berlin, Campus Virchow-Clinikum, Augustenburger Platz 1, 13353 Berlin, Germany.
    [Show full text]
  • Analytics for Improved Cancer Screening and Treatment John
    Analytics for Improved Cancer Screening and Treatment by John Silberholz B.S. Mathematics and B.S. Computer Science, University of Maryland (2010) Submitted to the Sloan School of Management in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Operations Research at the MASSACHUSETTS INSTITUTE OF TECHNOLOGY September 2015 ○c Massachusetts Institute of Technology 2015. All rights reserved. Author................................................................ Sloan School of Management August 10, 2015 Certified by. Dimitris Bertsimas Boeing Leaders for Global Operations Professor Co-Director, Operations Research Center Thesis Supervisor Accepted by . Patrick Jaillet Dugald C. Jackson Professor Department of Electrical Engineering and Computer Science Co-Director, Operations Research Center 2 Analytics for Improved Cancer Screening and Treatment by John Silberholz Submitted to the Sloan School of Management on August 10, 2015, in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Operations Research Abstract Cancer is a leading cause of death both in the United States and worldwide. In this thesis we use machine learning and optimization to identify effective treatments for advanced cancers and to identify effective screening strategies for detecting early-stage disease. In Part I, we propose a methodology for designing combination drug therapies for advanced cancer, evaluating our approach using advanced gastric cancer. First, we build a database of 414 clinical trials testing chemotherapy regimens for this cancer, extracting information about patient demographics, study characteristics, chemother- apy regimens tested, and outcomes. We use this database to build statistical models to predict trial efficacy and toxicity outcomes. We propose models that use machine learning and optimization to suggest regimens to be tested in Phase II and III clinical trials, evaluating our suggestions with both simulated outcomes and the outcomes of clinical trials testing similar regimens.
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]
  • A Abacavir Abacavirum Abakaviiri Abagovomab Abagovomabum
    A abacavir abacavirum abakaviiri abagovomab abagovomabum abagovomabi abamectin abamectinum abamektiini abametapir abametapirum abametapiiri abanoquil abanoquilum abanokiili abaperidone abaperidonum abaperidoni abarelix abarelixum abareliksi abatacept abataceptum abatasepti abciximab abciximabum absiksimabi abecarnil abecarnilum abekarniili abediterol abediterolum abediteroli abetimus abetimusum abetimuusi abexinostat abexinostatum abeksinostaatti abicipar pegol abiciparum pegolum abisipaaripegoli abiraterone abirateronum abirateroni abitesartan abitesartanum abitesartaani ablukast ablukastum ablukasti abrilumab abrilumabum abrilumabi abrineurin abrineurinum abrineuriini abunidazol abunidazolum abunidatsoli acadesine acadesinum akadesiini acamprosate acamprosatum akamprosaatti acarbose acarbosum akarboosi acebrochol acebrocholum asebrokoli aceburic acid acidum aceburicum asebuurihappo acebutolol acebutololum asebutololi acecainide acecainidum asekainidi acecarbromal acecarbromalum asekarbromaali aceclidine aceclidinum aseklidiini aceclofenac aceclofenacum aseklofenaakki acedapsone acedapsonum asedapsoni acediasulfone sodium acediasulfonum natricum asediasulfoninatrium acefluranol acefluranolum asefluranoli acefurtiamine acefurtiaminum asefurtiamiini acefylline clofibrol acefyllinum clofibrolum asefylliiniklofibroli acefylline piperazine acefyllinum piperazinum asefylliinipiperatsiini aceglatone aceglatonum aseglatoni aceglutamide aceglutamidum aseglutamidi acemannan acemannanum asemannaani acemetacin acemetacinum asemetasiini aceneuramic
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 8,512,679 B2 Hyde Et Al
    US0085 12679B2 (12) United States Patent (10) Patent No.: US 8,512,679 B2 Hyde et al. (45) Date of Patent: Aug. 20, 2013 (54) GLASSY COMPOSITIONS 2004/0228802 A1* 1 1/2004 Chang et al. ................. 424,102 2004/0265354 A1 12/2004 Ameri et al. 2005, OO19411 A1 1/2005 Colombo et al. (75) Inventors: Roderick A. Hyde, Redmond, WA (US); 2005, 0080028 A1 4/2005 Catchpole Lowell L. Wood, Jr., Bellevue, WA (US) 2005/0085434 A1 4/2005 Catchpole 2005/O123565 A1 6/2005 Subramony et al. (73) Assignee: Elwha LLC, Bellevue, WA (US) 2005/O1973O8 A1 9, 2005 Dalton et al. 2005/0277107 A1 12/2005 Toner et al. (*) Notice: Subject to any disclaimer, the term of this 2006, OO74376 A1 4/2006 Kwon 2006/0O83690 A1* 4/2006 Chang .......................... 424,102 patent is extended or adjusted under 35 2006/0099567 A1 5, 2006 Muller-Cohn et al. U.S.C. 154(b) by 131 days. 2006, O1274.15 A1 6/2006 Mayeresse 2006/0177494 A1 8, 2006 Cormier et al. (21) Appl. No.: 12/932,781 2006/0229557 A1 10/2006 Fathallah et al. 2007/0078376 A1 4/2007 Smith 2007, 0083 186 A1 4/2007 Carter et al. (22) Filed: Mar. 4, 2011 2007, 011081.0 A1 5, 2007 Smith 2007. O184096 A1 8, 2007 Ameri et al. (65) Prior Publication Data 2007/0275467 A1 11/2007 Louvet et al. US 2012/O225O11 A1 Sep. 6, 2012 2007/0298052 A1 12/2007 Mayeresse 2008/0095854 A1 4/2008 Catchpole 2008. O112915 A1 5/2008 Foldvariet al.
    [Show full text]
  • United States Patent (10) Patent No.: US 9,605,003 B2 Castro Et Al
    USOO9605 003B2 (12) United States Patent (10) Patent No.: US 9,605,003 B2 Castro et al. (45) Date of Patent: Mar. 28, 2017 (54) HETEROCYCLIC COMPOUNDS AND USES 5,294,612 A 3, 1994 Bacon et al. THEREOF 5,310,731 A 5/1994 Olsson et al. 5,364,862 A 11/1994 Spada et al. 5,420,419 A 5, 1995 Wood (71) Applicant: Infinity Pharmaceuticals, Inc., 5,428,125 A 6/1995 Hefner, Jr. et al. Cambridge, MA (US) 5,442,039 A 8/1995 Hefner, Jr. et al. 5,504,103 A 4/1996 Bonjouklian et al. (72) Inventors: Alfredo C. Castro, Woburn, MA (US); 5,506,347 A 4/1996 Erion et al. Catherine A. Evans, Somerville, MA 3: A 1999. St. al (US); Andre Lescarbeau, Somerville, 5.593.997 A 1/1997 f MA (US); Tao Liu, Wellesley, MA 5,646,128. A 7/1997 Firestein et al. (US); Daniel A. Snyder, Somerville, 5,652,366 A 7/1997 Spada et al. MA (US); Martin R. Tremblay, 39 A s 3. E. et al Melrose, MA (US); Pingda) Ren, San 5,674,998. A 10/1997 Boyeragwat et al.et al. Diego, CA (US); Yi Liu, San Diego, 5,686,455. A 1 1/1997 Adams et al. CA (US); Liansheng Li, San Diego, 5,736,554. A 4/1998 Spada et al. CA (US); Katrina Chan, Fremont, CA 5,747,235 A 5/1998 Farid et al. (US) 5,756,711 A 5/1998 Zilch et al. 5,763,596 A 6/1998 Boyer et al.
    [Show full text]
  • Download Report
    Magellan Rx Management Medical Pharmacy Trend Report 2013 FOURTH EDITION 2 TREND REPORT 2013 CONTENts 4 2013 Survey Methodology and Demographics Magellan Rx Management Medical Pharmacy Trend Report™ combines primary survey research data collection with Published by: secondary data analysis of medical injectable claims. Magellan Rx Management 6870 Shadowridge Dr., Suite 111 Orlando, FL 32812 6 Report Summary and Conclusions Tel: 866-664-2673 Fax: 866-994-2673 www.magellanhealth.com 7 Payor Survey Data Publishing Staff A survey conducted among health plan executives MEDIA DIRECtor provides a real-world view of current payor coverage Erika I. Ruiz-Colon strategies and tactics. MEDIA MANAGER Kayla Killian MEDICAL BENEFIT AND DRUG FORMULARY ©2014 Magellan Rx Management. Magellan Rx Management 2013 Medical Pharmacy Trend Report TM is published in conjunction with Krames ProVIDER REIMBURSEMENT staywell. all rights reserved. all trademarks are the property of their respective owners. Printed BENEFIT DESIGN in the U.S.A. the content — including text, graphics, images and information obtained from third parties, DISTRIBUTION CHANNEL MANAGEMENT licensors and other material (“content”) — is for informational purposes only. The content is UTILIZatION MANAGEMENT not intended to be a substitute for professional medical advice, diagnosis or treatment. OperatIONAL ImproVEMENTS 39 Health Plan Claims Data Contributors Magellan Rx Management’s analysis of medical injectable Robert Louie, R.Ph. claims allows for a practical interpretation of the drivers VICE PRESIDENT, CLINICAL MEDICAL PHARMACY Jeanine Boyle, J.D., M.P.H. related to trend and spend for these products. VICE PRESIDENT, HEALTH CARE REFORM StrateGY Erika I. Ruiz-Colon TREND DRIVERS DIRECtor, SALES AND StrateGIC OperatIONS Mary Talberg DIRECtor, IT FINANCIAL INFormatION MANAGEMENT MANAGEMENT OF SPEND DRIVERS Michele Marsico DIRECtor, ANALYTICS NatIONAL ProVIDER TRENDS Kayla Killian ProJECT MANAGER INSIGHTS FOR 2013 Jason Peterson, R.Ph.
    [Show full text]
  • 411 Development of Cross-Resistance in Urothelial Cancer Cell Lines with Acquired Resistance Against Gemcitabine and Cisplatin
    411 Development of cross-resistance in urothelial cancer cell lines with acquired resistance against gemcitabine and cisplatin. Is chemo- or radiation-therapy still working? Eur Urol Suppl 2014;13;e411 Print! Vallo S.1, Michaelis M.2, Bartsch G.1, Rödel F.3, Haferkamp A.1, Cinatl J.4 1University Hospital Frankfurt, Dept. of Urology, Frankfurt am Main, Germany, 2University of Kent, Dept. of Molecular Processing and School of Biosciences, Canterbury, United Kingdom, 3University Hospital Frankfurt, Dept. of Radiation Therapy and Oncology, Frankfurt am Main, Germany, 4University Hospital Frankfurt, Dept. of Virology, Frankfurt am Main, Germany INTRODUCTION & OBJECTIVES: Metastatic or advanced urothelial cancer is still associated with a poor prognosis. Combination- chemotherapy with gemcitabine and cisplatin is standard of care with a long-term survival of only 12-14 months. Here, we used 18 different chemotherapeutic substances with different modes of action as a treatment in 6 different parental urothelial cancer cell lines, 6 corresponding gemcitabine-resistant sublines and 6 cisplatin-resistant sublines to identify promising new second-line chemotherapy regimens. In addition, the influence of acquired chemoresistance on the cancer cell sensitivity to radiotherapy was investigated. MATERIAL & METHODS: The drug-resistant sub-lines were established by continuous exposure to increasing drug concentrations. Cell viability was investigated by MTT assay. Growth characteristics were determined by daily cell counting. Effects of radiation were detected by clonogenic survival assay. RESULTS: The most effective compounds were vinflunine, vinblastine, and topotecan that exerted in 11 of the 12 investigated cisplatin- or gemcitabine-resistant urothelial carcinoma cell lines similar effects like those detected in the respective parental cell lines.
    [Show full text]
  • Microtubule-Binding Agents: a Dynamic Field of Cancer Therapeutics. Charles Dumontet, Mary Ann Jordan
    Microtubule-binding agents: a dynamic field of cancer therapeutics. Charles Dumontet, Mary Ann Jordan To cite this version: Charles Dumontet, Mary Ann Jordan. Microtubule-binding agents: a dynamic field of cancer thera- peutics.. dressNature Reviews Drug Discovery, 2010, 9 (10), pp.790-803. 10.1038/nrd3253. inserm- 00526519 HAL Id: inserm-00526519 https://www.hal.inserm.fr/inserm-00526519 Submitted on 4 Apr 2011 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Microtubule binding agents: a dynamic target for cancer therapeutics Charles Dumontet Inserm, U590, Lyon, F-69008, France ; Université Lyon 1, ISPB, Lyon, F-69003, France ; Mary Ann Jordan Dept. Mol., Cell., Devel. Biology/ Neuroscience Res. Inst. University of California Santa Barbara Santa Barbara, California, 93106-9610, U.S.A. Acknowledgements: This work was supported in part by the Association pour la Recherche contre le Cancer and the Ligue contre le Cancer Conflicts of interest: CD has received research funding from Pierre Fabre, Sanofi-Aventis and has worked as a consultant for Sanofi-Aventis and Bristol Myers Squibb MAJ has received research support from Bristol Myers Squibb, Eisai Pharmaceuticals, and Immunogen Correspondence should be addressed to: Charles Dumontet INSERM 590 Faculté Rockefeller 8 avenue Rockefeller 69008 Lyon France Tel 33 4 78 77 72 36 Fax 33 4 72 11 95 05 E-mail: [email protected] 2 Preface Microtubules are dynamic filamentous cytoskeletal proteins that are an important therapeutic target 4 in tumor cells.
    [Show full text]
  • WO 2010/091198 Al
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 12 August 2010 (12.08.2010) WO 2010/091198 Al (51) International Patent Classification: (74) Agents: KONSKI, Antoinette F. et al; FOLEY & A61K 31/045 (2006.01) A61P 35/00 (2006.01) LARDNER LLP, 975 Page Mill Road, Palo Alto, Califor A61K 47/10 (2006.01) nia 94304-1013 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US20 10/023228 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (22) International Filing Date: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, 4 February 2010 (04.02.2010) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (26) Publication Language: English ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (30) Priority Data: NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, 61/150,7 14 6 February 2009 (06.02.2009) US SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant (for all designated States except US): UNI¬ VERSITY OF SOUTHERN CALIFORNIA [US/US]; (84) Designated States (unless otherwise indicated, for every 3740 McClintock Avenue, EEB13 1, Los Angeles, Cali kind of regional protection available): ARIPO (BW, GH, fornia 90089-2561 (US).
    [Show full text]
  • Jevtana, INN-Cabazitaxel
    20 January 2011 EMA/CHMP/66633/2011 Committee for Medicinal Products for Human Use (CHMP) Assessment Report For Jevtana (cabazitaxel) Procedure No.: EMEA/H/C/002018 Assessment Report as adopted by the CHMP with all information of a commercially confidential nature deleted 7 Westferry Circus ● Canary Wharf ● London E14 4HB ● United Kingdom Telephone +44 (0)20 7418 8400 Facsimile +44 (0)20 7523 7455 E-mail [email protected] Website www.ema.europa.eu An agency of the European Union Table of contents 1. Background information on the procedure ............................................ 4 1.1. Submission of the dossier.................................................................................... 4 1.2. Steps taken for the assessment of the product ....................................................... 5 2. Scientific discussion ................................................................................ 6 2.1. Introduction ...................................................................................................... 6 2.2. Quality aspects .................................................................................................. 7 2.2.1. Introduction ................................................................................................... 7 2.2.2. Active Substance............................................................................................. 7 2.2.3. Finished Medicinal Product ................................................................................ 8 2.2.4. Discussion and Conclusion
    [Show full text]