Journal of Virology

JOURNAL OF VIROLOGY

VOLUME 50 0 JUNE 1984 * NUMBER 3 Edward M. Scolnick, Editor in Chief (1987) Merck Sharp & Dohme Research Laboratories West Point, Pa. David T. Denhardt, Editor (1987) Harold S. Ginsberg, Editor (1984) Michael B. A. Oldstone, Editor (1988) University of Western Ontario Columbia University Scripps Clinic & Research Foundation London, Ontario, Canada New York, N.Y. La Jolla, Calif. Bernard N. Fields, Editor (1988) Robert M. Krug, Editor (1987) Robert A. Weisberg, Editor (1988) Harvard Medical School Sloan-Kettering Institute National Institute of Child Health and Boston, Mass. New York, N.Y. Human Development Bethesda, Md. EDITORIAL BOARD David Baltimore (1984) Hidesaburo Hanafusa (1986) Bernard Moss (1986) Bart Sefton (1985) Amiya K. Banerjee (1985) William S. Hayward (1984) Fred Murphy (1986) Phillip A. Sharp (1985) Andrew Becker (1985) Martin Hirsch (1986) Nancy G. Nossal (1984) Thomas E. Shenk (1984) Tamar Ben-Porat (1984) John J. Holland (1984) Abner Notkins (1986) Charles J. Sherr (1984) Kenneth I. Berns (1985) Ian H. Holmes (1986) J. Thomas Parsons (1986) Saul J. Silverstein (1985) Michael Botchan (1986) Robert W. Honess (1986) Ulf G. Petterson (1986) Lee D. Simon (1984) David Botstein (1985) Nancy Hopkins (1986) Lennart Philipson (1984) Ann Skalka Dennis T. Brown (1984) Peter M. Howley (1984) Lewis I. Pizer (1984) (1985) Ahmad I. Bukhari (1984) Alice S. Huang (1984) Craig R. Pringle (1986) Patricia G. Spear (1984) Barrie J. Carter (1984) Tony Hunter (1986) Carol Prives (1986) Nat Sternberg (1986) Purnell Choppin (1986) Masayori Inouye (1985) Robert Purcell (1986) Mark F. Stinski (1986) John M. Coffin (1986) Robert Kamen (1985) Fred Rapp (1984) F. William Studier (1984) Geoffrey M. Cooper (1984) Thomas J. Kelly, Jr. (1985) Dan S. Ray (1986) Lawrence S. Sturman (1985) Richard Courtney (1986) George Khoury (1984) M. E. Reichmann (1985) Jesse Summers (1985) Walter Doerfler (1986) Elliott Kieff (1984) Gordon M. Ringold (1984) William Summers (1985) Peter Dougherty (1986) Jonathan A. King (1984) Harriet Robinson (1985) John M. Taylor (1984) Harrison Echols (1984) Daniel Kolakofsky (1986) William S. Robinson (1986) Howard M. Temin (1985) Elvera Ehrenfeld (1986) Robert Lamb (1985) Bernard Roizman (1985) George F. Vande Woude (1986) Robert N. Eisenman (1985) Robert A. Lazzarini (1984) Naomi Rosenberg (1986) Inder Verma (1986) Suzanne U. Emerson (1986) Myron Levine (1985) Roland R. Rueckert (1985) Edward K. Wagner (1986) S. Jane Flint (1984) Douglas R. Lowy (1986) Norman P. Salzman (1984) Eckard Wimmer (1985) Yasuhiro Furuichi (1985) Robert Martin (1984) Joseph Sambrook (1985) Owen Witte (1986) Costa Georgopolous (1986) Thomas Merigan (1986) Charles E. Samuel (1986) Charles Hamish Young (1986) Walter Gerhard (1986) George Miller (1984) Priscilla A. Schaffer (1984) Julius S. Youngner (1986) Larry M. Gold (1985) Lois K. Miller (1985) Sondra Schlesinger (1986) Peter Gruss (1985) Peter Model (1986) June R. Scott (1986)

Helen R. Whiteley, Chairman, Publications Board Walter G. Peter III, Director of Publications Linda M. Illig, Managing Editor, Journals Paula R. Ellison, Production Editor

The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 I St., NW, Washington, DC 20006, is devoted to the dissemination offundamental knowledge concerning viruses of bacteria, plants, and animals. Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry, biophysics, genetics, immunology, morphology, physiology, and pathogenesis and immunity. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Department. The Journal is issued monthly, four volumes per year. The nonmember subscription price is $249 per year; single copies are $21. The member subscription price is $37 (foreign, $49 [surface rate]) per year; single copies are $7.00. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 I St., NW, Washington, DC 20006 (phone: 202 833-9680). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because offailure to report an address change or for issues "missing from files" will not be allowed. Second-class postage paid at Washington, DC 20006, and at additional mailing offices. POSTMASTER: Send address changes to Journal of Virology, ASM, 1913 I St., NW, Washington, DC 20006. Made in the U.S.A. Copyright © 1984, American Society for Microbiology. a* MIfUXtA, E I J; IIIJ4 All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center, 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index

Adachi, Akio, 813 Facchini, Jole, 964 Kumel, Gunter, 805 Rozenblatt, Shmuel, 939 Adler-Storthz, Karen, 951 Faulkner, Peter, 739 Kurilla, Michael G., 773 Rueckert, Roland R., 957 Allen, Rae, 748 Fischer, Duncan K., 822 Anders, E. Margot, 960 Fukui, Yasuhisa, 854 Anderson, Dwight L., 766 Fukui, Yoshiko, 854 Laprevotte, Ivan, 884 Saito, Izumu, 854 Anderson-Sillman, Kathleen, 922 Furuta, Takahisa, 970 Larder, Brendan A., 838 Sakai, Koji, 813 Arbuthnott, Carolyn, 725 Legault-Demare, Jean, 671 Sangar, D. V., 878 Austin, M., 684 Levine, Myron, 805 Scalzo, Anthony A., 960 Galibert, Francis, 884 Schroder, Claus H., 805 Glorioso, Joseph, 805 Scott, Miller O., 895 Bartal, Sharon, 922 Grubb, Anders, 7% Shedd, Duane, 822 Baumann, Ernst, 943 Gruss, Claudia, 943 Mak, Tak W., 759 Sheridan, John F., 947 Bellini, William J., 939 Matsuyama, Mutsushi, 813 Sherr, Charles J., 884 Bernards, Rend, 847 Mayer, Bruce J., 904 Shimojo, Hiroto, 854 Billiau, A., 878 McClintock, P. R., 684 Shiroki, Kazuko, 854 Biron, Christine A., 698 Habu, Sonoku, 698 Miller, George, 822 Silver, Jonathan, 872 Bjornsti, Mary-Ann, 766 Hallberg, Torgny, 796 Morishima, T., 684 Smadja-Joffe, Florence, 717 Blenis, John, 966 Halpern, M. E., 733 Murphy, Frederick A., 779 Smiley, J. R., 733 Blomberg, Jonas, 7% Hampe, Annie, 884 Stacey, Alexander, 725 Burns, John W., Sr., 951 Hashimoto, Seiji, 854 Stocking, Carol, 717 Burroughs, J. N., 878 Henkel, Richard D., 951 Stow, Nigel D., 708 Holloway, Brian P., 773 Nakanishi, Shigetada, 813 Summers, Jesse, 832 Houweling, Ada, 847 Neckameyer, Wendi S., 914 Szczesiul, Mark, 805 Cabradilla, Cirilo D., 773 Hulen, Christian, 671 Nepveu, Alain, 678 Capobianchi, Maria R., 964 Humphries, Eric H., 748 Niwa, Ohtsura, 813 Chartrand, Pierre, 678 Norris, David, 895 Takemoto, Kenneth K., 954 Churcher, Mark J., 838 Notkins, A. L., 684 Tershak, Daniel R., 922 Clark, Stephen P., 759 Ichihashi, Yasuo, 929 Tsuruhara, Takashi, 929 Clarke, B. E., 878 Ishimoto, Akinori, 813 Coggins, Lesley, 725 Oie, Masayasu, 929 Collen, D., 878 Okumura, Ko, 698 Vaessen, Marie-Josee, 847 Cordingley, Mike G., 708 Johansson, P. J. Hugo, 796 Ostertag, Wolfram, 717, 725 van der Eb, Alex J., 847 Oxelius, Vivi-Anne, 796 Villarreal, Luis P., 779 Vonderfecht, Steven L., 947 Darby, Graham, 838 Kai, Kazushige, 970 de Leeuw, Mike G. W., 847 Kanda, Tadahito, 954 Dianzani, Ferdinando, 964 Kato, Hiroyuki, 854 Preston, Chris M., 708 Wallenburg, John C., 678 Dreesman, Gordon R., 951 Keene, Jack D., 773 Wang, Lu-Hai, 904, 914 Dubensky, Thomas W., 779 Keil, Gunther M., 784 Weigel, Ronald J., 822 Kennedy, Ronald C., 951 Reagan, Kevin J., 691 Welsh, Raymond M., 698 Khan, Arifa S., 864 Reilly, Bernard E., 766 White, David O., 960 Ebeling-Keil, Angelika, 784 Kimelman, David, 895 Ricciardi, Robert P., 895 Wimmer, Eckard, 957 Edelstein, Brian, 904 Kitamura, Naomi, 813 Richardson, Chris D., 939 Wunner, William H., 691 Enders, Lynn D., 947 Knippers, Rolf, 943 Robert, Marie F., 822 Englund, George, 939 Kollek, Regine, 717, 725 Rogler, Charles E., 832 Erikson, R. L., 966 Koprowski, Hilary, 691 Rohel, Dennis Z., 739 Yolken, Robert H., 947 Eydelloth, Ronald S., 947 Koszinowski, Ulrich H., 784 Rowlands, D. J., 878 Yoon, J. W., 684 AUTHOR INDEX VOLUME 50

Aaronson, Robert P., 118 Cordingley, Mike G., 708 Gregoire, Diane, 275 Klempnauer, Karl-Heinz, 280 Abidi, Tanveer F., 380 Couez, Dominique, 275 Griffith, Gary R., 77 Knippers, Rolf, 943 Adachi, Akio, 813 Crawford, Lionel V., 457 Grodzicker, Terri, 598 Kobayashi, Susumu, 649 Adler-Storthz, Karen, 951 Creager, Richard S., 118 Grubb, Anders, 7% Kollek, Regine, 717, 725 Allen, Rae, 748 Cuypers, Theo, 432 Grubman, Marvin J., 579 Koomey, J. Michael, 662 Anders, E. Margot, 960 Gruss, Claudia, 943 Kopchick, John, 271 Anderson, Carl W., 387 Darby, Graham, 838 Gupta, Phalguni, 267 Koprowski, Hilary, 691 Anderson, Dwight L., 766 Dasgupta, Asim, 515 Koszinowski, Ulrich H., 784 Anderson-Siliman, Kathleen, 922 Dauenhauer, Steven A., 13 Habu, Sonoku, 698 Krystal, Mark, 118 Arbuthnott, Carolyn, 725 Davatelis, Viveca, 445 Hadlow, William J., 38 Kuhn, Christa, 335 Arias, Carlos F., 657 Davison, John, 629 Hagen, Fred S., 86 Kumel, Gunter, 805 Arlinghaus, Ralph B., 478 Delange, A. M., 408 Hallberg, Torgny, 7% Kurilla, Michael G., 773 Astry, Calvin L., 287 de Leeuw, Mike G. W., 847 Halpern, M. E., 733 Kwolek, Christopher J., 654 Austin, M., 684 Deschamps, Jacqueline, 275 Hammond, Charlotte, 125 Avery, Roger J., 439 Desrosiers, Ronald C., 662 Hampe, Annie, 884 Dianzani, Ferdinando, 964 Hanafusa, Hidesaburo, 325 Labedan, Bernard, 213 Babiss, Lee E., 202 Doerfler, Walter, 497 Hanahan, Douglas, 606 LaFemina, Robert, 145 Bamford, Dennis H., 309 Dohner, Dennis E., 615 Hanecak, Ronnie, 507 Lafontaine, Dominique, 629 Bartal, Sharon, 922 Dorner, Andrew J., 507 Hardung, Michael, I Lanford, Robert E., 636 Batterson, William, 645 Dowbenko, Donald, 579 Hashimoto, Seiji, 854 Laprevotte, Ivan, 884 Baumann, Ernst, 943 Downey, James F., 30 Hata, Tissa, 363 Larder, Brendan A., 838 Baumann, Raymond P., 13 Dreesman, Gordon R., 951 Henkel, Richard D., 951 Larsen, Hal S., 56 Bayley, Stanley T., 30 Dubensky, Thomas W., 541, 779 Herman, Ronald C., 524 Larson, Ruby, 666 Bell, John R., 657 Duprey, Elizabeth, 507 Herr, Winship, 155 Legault-Demare, Jean, 213, 671 Bellini, William J., 939 Herz, Ruth, 445 Leppard, Keith N., 457 Bernards, Rene, 847 Ebeling-Keil, Angelika, 784 Heston, Lee, 174 Levine, Myron, 805 Berns, Anton, 432 Eberle, R., 316 Heuertz, Solange, 275 Levy, Julia G., 572 Bikel, Ilan, 623 Echle, Birgit, I Hilliard, J. K., 316 Lewis, James B., 387 Billiau, A., 878 Edelstein, Brian, 904 Hinze, Ehleen, 572 Lin, Jung-Chung, 50 Bina, Minou, 471 Ellman, Matthew, 623 Hocko, Janet, 515 Lin, William, 363 Biron, Christine A., 698 Emerman, Michael, 42 Holloway, Brian P., 773 Livingston, David M., 623 Bishop, J. Michael, 125, 280 Emerson, Suzanne Urjil, 255 Hope, R. G., 547 Lodmell, Donald L., 359 Bjornsti, Mary-Ann, 766 Enders, Lynn D., 947 Horohov, David W., 56 L6pez, Susana, 657 Black, Lindsay W., 293 Englund, George, 939 Hors-Cayla, Marie-Claude, 275 Lubbert, Hermann, 497 Blenis, John, 966 Epstein, Alan L., 372 Houweling, Ada, 847 Block, W., 408 Erikson, R. L., 966 Huang, Alice S., 86 Maandag, Els Robanus, 432 Blomberg, Jonas, 796 Ernoult-Lange, M., 163 Huang, Chiao-Chain, 125 Macaulay, C., 408 Boelens, Wilbert, 432 Ertl, Hildegund C. J., 425 Huez, Georges, 275 Mak, Tak W., 759 Branton, Philip E., 30 Evelegh, Carole M., 30 Hulen, Christian, 671 Marsden, H. S., 547 Braun, Daniel K., 645 Eydelloth, Ronald S., 947 Humphries, Eric H., 748 Marshall, Ian D., 66, 73 Brody, Edward, 191 Hwang, Lih-Hwa Sherry, 417 Mathey-Prevot, Bernard, 325 Brown, Nicole V., 478 Facchini, Jole, 964 Matsuyama, Mutsushi, 813 Buckmaster, A., 547 Faras, Anthony J., 465 Ichihashi, Yasuo, 929 May, E., 163 Burghoff, Robert L., 662 Faulkner, Peter, 739 Ingman-Baker, Jane, 572 May, P., 163 Burns, John W., Sr., 951 Feng, Mei-Fu, 56 Irmiere, Alice, 145 Mayer, Bruce J., 904 Burny, Arsene, 275 Ferrer, J. F., 267 Ishida, Masatoshi, 649 McClintock, P. R., 684 Burroughs, J. N., 878 Fields, Alan, 145 Ishimoto, Akinori, 813 McFadden, G., 408 Butel, Janet S., 636 Figge, James, 623 Medveczky, Peter, 248 Finberg, Robert W., 425 Jackson, Richard J., 507 Mileham, Alan J., 619 Cabradilla, Cirilo D., 773 Fischer, Duncan K., 822 Jakab, George J., 287 Miller, George, 174, 822 Capobianchi, Maria R., 964 Flanagan, Thomas D., 380 Jamison, Richard M., 641 Miller, Patricia Black, 529 Carter, Jeanne K., 301 Fleckenstein, Bernhard, 662 Jenkins, Nancy A., 237 Milner, Andrew R., 66, 73 Cattaneo, Roberto, 335 Franssen, Henk, 183 Johansson, P. J. Hugo, 7% Mindich, Leonard, 309 Caughman, Gretchen B., 13 Fukui, Yasuhisa, 132, 854 Jubelt, Burk, 137 Minson, A. C., 547 Cave, David R., 86 Fukui, Yoshiko, 845 Mishra, Lalji, 615 Champness, Wendy Cooley, 555 Furuno, Akemi, 451 Kai, Kazushige, 970 Miyamura, Tatsuo, 451 Chartrand, Pierre, 678 Furuta, Takahisa, 970 Kanda, Tadahito, 100, 954 Moerman, Marja, 183 Chesebro, Bruce, 359 Kasamatsu, Harumi, 363 Moore, Douglas M., 579 Chinsky, Jeffrey, 271 Galibert, Francis, 884 Kashmiri, S. V. S., 267 Moore, Robert N., 56 Churcher, Mark J., 838 Ganem, Don, 563 Kato, Hiroyuki, 854 Moreau, P., 163 Clark, Stephen P., 759 Gardella, Thomas, 248 Keene, Jack D., 773 Morgan, Donald O., 579 Clarke, B. E., 878 Gelb, Lawrence D., 615 Keil, Gunther M., 784 Morishima, T., 684 Clewley, Jon P., 439 Gerhard, Brigitte, 529 Kennedy, Richard C., 38 Morrow, Casey D., 515 Coffin, John M., 397 Gibson, Wade, 145 Kennedy, Ronald C., 951 Motobayashi-Nakajima, Yumiko, Coggins, Lesley, 725 Gilbert, Walter, 155 Kerr, Ian M., 220, 229 352 Collen, D., 878 Gilboa, Eli, 417 Kettmann, Richard, 275 Mueller, T., 408 Collett, Marc S., 666 Ginsberg, H. S., 202 Khan, Arifa S., 864 Mulder, Carel, 248, 662 Concannon, Patrick, 654 Glorioso, Joseph, 805 Khiroya, Raman, 397 Mullbacher, Arno, 73 Consigli, Richard A., 77 Gluzman, Yakov, 606 Kimelman, David, 895 Murphy, Edwin C., Jr., 478 Cook, Frank, 439 Goldbach, Rob, 183 Kitamura, Naomi, 813 Murphy, Frederick A., 779 Copeland, Neal G., 237 Green, Todd L., 255 Kitasato, Hidero, 352 Murray, Noreen E., 619

i ii AUTHOR INDEX J. VIROL. Nakada, Susumu, 118 Rey-Bellet, Veronique, 587 Selten, Gerard, 432 Vaessen, Marie-Josee, 847 Nakanishi, Shigetada, 813 Rezelman, Geertje, 183 Semler, Bert L., 507 van Arkel, Gerard A., 533 Nash, Michael, 478 Ricciardi, Robert P., 895 Sen, Ganes C., 445 van Breemen, Richard, 145 Navab, Mohamad, 515 Rice, Andrew P., 220, 229 Shedd, Duane, 822 van der Avoort, Harrie G. A. M., Neckameyer, Wendi S., 914 Richardson, Chris D., 939 Sheridan, John F., 947 533 Nepveu, Alain, 678 Robert, Marie F., 822 Sherr, Charles J., 884 van der Eb, Alex J., 847 Nerome, Kuniaki, 649 Roberts, Peter C., 439 Shibata, Mitsuo, 649 van der Ende, Arie, 533 Ng, Shi-Chung, 471 Roberts, Thomas, 623 Shibuya, Masabumi, 325 Van Doren, Kevin, 606 Niwa, Ohtsura, 813 Roberts, Walden K., 220 Shimojo, Hiroto, 132, 854 van Wezenbeek, Peter, 432 Norris, David, 895 Robertson, Betty H., 579 Shiroki, Kazuko, 132, 854 Varmus, Harold E., 563 Norton, John D., 439 Robertson, Donald L., 632 Silver, Jonathan, 872 Venkatesan, Sundararajan, 92 Notkins, A. L., 684 Robinson, Patricia S., 343 Smadja-Joffe, Florence, 717 Villarreal, Luis P., 541, 779 Roggendorf, Michael, 335 Smart, John E., 387 Vonderfecht, Steven L., 947 O'Callaghan, Dennis J., 13 Rogler, Charles E., 832 Smiley, J. R., 733 Ohishi, Hideyuki, 352 Rohel, Dennis Z., 739 Smith, M. Carolyn, 50 Oie, Masayasu, 929 Roizman, Bernard, 645 Smith, R. E., 301 Wallenburg, John C., 678 Okumura, Ko, 698 Rouse, Barry T., 56 Snyder, Larry, 555 Walter, Gernot, 1, 636 Omer, Charles A., 465 Rowlands, D. J., 878 Soeiro, Ruy, 271 Wang, Lu-Hai, 904, 914 Ono, Masao, 352 Rozenblatt, Shmuel, 939 Spear, Patricia G., 258 Warren, R. A. J., 529 Openshaw, Harry, 263 Rozhon, Edward J., 137 Stacey, Alexander, 725 Washington, Lynette D., 60 Ostertag, Wolfram, 717, 725 Rueckert, Roland R., 957 Staczek, John, 13 Weigel, Ronald J., 822 Oxelius, Vivi-Anne, 796 Rutter, William J., 563 Stallcup, Michael R., 60 Weisbeek, Peter J., 533 Oya, Akira, 649 Standring, David N., 563 Wejman, John C., 237 Sairenji, Takeshi, 248 Stein, Robert B., 343 Wellinghoff, Wanda J., 615 Pagano, Joseph S., 50 Saito, Izumu, 132, 854 Stern, David F., 22 Welsh, Raymond M., 698 Palese, Peter, 118 Sakai, Koji, 813 Stillman, Bruce W., 598 White, David O., 960 Palfreyman, J. W., 547 Salser, Winston A., 654 Stocking, Carol, 717 White, Eileen, 598 Palma, Eduardo L., 86 Samarut, Jacques, 325 Stow, Nigel D., 708 Will, Hans, 335 Pawson, Tony, 572 Sangar, D. V., 878 Strauss, James H., 657 Wilson, Allison K., 137 Pestka, Sidney, 445 Satake, Masanobu, 92 Summers, Jesse, 832 Wimmer, Eckard, 507, 957 Pfaff, Eberhard, 335 Scalzo, Anthony A., 960 Szczesiul, Mark, 805 Wong, Jade L., 478 Preston, Chris M., 708 Schaller, Heinz, 335 Szpirer, Claude, 275 Wunner, William H., 691 Prewitt, R. Scott, 60 Scheidtmann, Karl H., 636 Szpirer, Josiane, 275 Purchio, A. F., 666 Scheidtmann, Karl Heinz, I Yamaguchi, Ryoji, 649 Schickedanz, Jorg, 636 Takemoto, Kenneth K., 100, 954 Yamanouchi, Kazuya, 489 Quint, Wim, 432 Schlossman, Robert, 623 Taylor, Benjamin A., 237 Yolken, Robert H., 947 Schmitt, Robert C., 387 Temin, Howard M., 42 Yoon, J. W., 684 Rabson, Michael, 174 Schroder, Claus H., 805 Tershak, Daniel R., 922 Yoshiike, Kunito, 451 Race, Richard E., 38 Schwartz, Robert S., 397 Thermes, Claude, 191 Yoshikawa, Yasuhiro, 489 Raskas, Heschel J., 106 Scolnick, Edward M., 343 Thomas, Christopher Y., 397 Yoshioka, Yasuyuki, 649 Reagan, Kevin J., 691 Scott, Miller O., 895 Tigges, Michael A., 106 Reilly, Bernard E., 766 Seal, Lawton A., 641 Tosi, Francois, 213 Resnick, Robert, 465 Sefton, Bartholomew M., 22 Tsuruhara, Takashi, 929 Zachary, Arthur, 293 Revel, Helen R., 619 Sekizawa, Tsuyoshi, 263 Turler, Hans, 587 Zezulak, Kathleen M., 258 SUBJECT INDEX VOLUME 50

2-5A immunity nonpermissive chicken embryo fibro- interferon mice, 73 blasts, 748 vaccinia virus, 220 mice permissive chicken embryo fibro- vaccinia virus immunity, 73 blasts, 748 interferon, 220 in utero infections, 66 replication, 748 Active transport pregnancy, 73 Avian sarcoma virus bacteriophage T5, 671 non-abortogenic PRCII strain Acyclovir in utero infections, 66 v-fps nucleotide sequence, 125 herpes simplex virus resistance loci, 838 mice, 66 recovered Adenovirus 2 Antibodies induction of tumors, 904 Ad2tslll monoclonal mapping of deletions, 904 defective viral DNA replication, 598 Epstein-Barr virus, 372 src deletion mutants, 904 degradation of cellular DNA, 598 Fujinami avian sarcoma virus, 572 reverse transcription in vitro independent mutations, 598 Antigens strong-stop plus DNA synthesis, 465 early region 1B cellular tumor p53 RNA primer coterminal proteins, 387 simian virus 40 large T, 457 strong-stop plus DNA synthesis, 465 early region 4 early strong-stop plus DNA synthesis mRNA splice junctions, 106 Epstein-Barr virus, 372 reverse transcription in vitro, 465 oncogenicity fusion protein RNA primer, 465 transforming region, 847 adenovirus 12 early region 1A-P-ga- Avian sarcoma virus UR2 transforming region lactosidase, 895 characterization, 914 oncogenicity, 847 hepatitis B surface molecular cloning, 914 Adenovirus 12 cultured murine cells, 563 transforming sequence, 914 early region 1A gene transcription, 563 bacteria, 895 presurface region, 563 early region lA-,3-galactosidase fu- hepatitis B virus Bacteriophage sion protein antigen, 895 simian virus 40 vector, 335 ,29 monospecific antiserum, 895 large T in vitro DNA-gp3 packaging, 766 El gene polyomavirus, 587 4W-14 soft-agar colony-forming rat cell lines, simian virus 40, 1, 457, 636 DNA synthesis, 529 854 mouse lymphocyte mutants, 529 transformed rat cell lines, 854 endogenous xenotropic murine leuke- polypeptide synthesis, 529 E4 gene mia virus, 237 4X174 soft-agar colony-forming rat cell lines, mutant T regions of incompatibility, 533 854 simian virus 40-transformed human single-stranded DNA, 533 transformed rat cell lines, 854 cell line simian virus 80, 943 G4 rat cell lines neutralization regions of incompatibility, 533 El gene, 854 simian rotavirus SAl1, 657 single-stranded DNA, 533 E4 gene, 854 nuclear X-T4 hybrid soft-agar colony-forming, 854 Epstein-Barr virus, 822 thymidine kinase, 619 transformed, 854 small T T4 thymidine kinase gene, 619 Adenovirus 5 simian virus 40, 623 PRD1 early region 1A T DNA protein complex, 309 adenovirus 12 early region 1A-,-ga- K virus, 954 T4 lactosidase fusion protein anti- mutant, 943 antipolarity, 191 gen, 895 Autographa californica early transcription units, 191 monospecific antiserum, 895 nuclear polyhedrosis virus gol site, 555 early region 1B early transcripts, 497 in vivo encapsidation of DNA, 293 gene product, 202 late transcripts, 497 plasmid transformation, 555 shutoff of host protein synthesis, 202 transcripts, 739 temporal heterogeneity, 191 Adenovirus 7 Avian infectious bronchitis virus thymidine kinase gene, 619 simian virus 40-adenovirus 7 hybrids genome UV irradiation, 293 simian virus 40 large T antigen, 636 coronavirus multiplication, 22 T5 Adenoviruses virion protein genes, 22 alteration of active transport, 671 early region 1 Avian leukemia virus direction of transcription, 629 integration of viral DNA, 606 E26 first-step transfer DNA, 629 eucaryotic cells, 606 gag genes, 280 Bovine leukemia virus helper-independent recombinant myb genes, 280 cattle, 267 early region 1, 606 neoplastic transformation, 280 genome eucaryotic cells, 606 Avian leukosis virus transcriptional control, 267 integration of viral DNA, 606 hyperlipidemia, 301 non-immunoglobulin plasma protein, Aleutian disease virus Avian paramyxovirus 267 low virulence genomic analysis, 649 provirus royal pastel mink, 38 immunological analysis, 649 tumors, 275 Alphavirus Japan, 649 tumors abortogenic wild ducks, 649 provirus, 275 in utero infections, 66 Avian retrovirus Bovine viral diarrhea virus mice, 66 endogenous proteins, 666

iii iv SUBJECT INDEX J. VIROL.

Calcium endogenous avian retrovirus, 748 herpes simplex virus, 263 entry blockers Chromatin Encephalomyocarditis virus gamma interferon, 964 simian virus 40 temperature-sensitive diabetogenic effect Capsids BC mutants resistant mice, 684 simian virus 40 temperature-sensitive capsids, 471 hybrid interferon BC mutants Coliphage antiviral activity, 445 chromatin, 471 T5 protein-inducing activity, 445 Cattle DNA ejection process, 213 interferon bovine leukemia virus, 267 free TonA protein, 213 hybrid, 445 Cells liposome-associated TonA protein, recombinant human leukocyte, 445 B 213 recombinant human leukocyte interfer- influenza virus, 960 TonA protein, 213 on COS-1 Coronavirus antiviral activity, 445 Epstein-Barr virus nuclear antigen, avian infectious bronchitis virus genome protein-inducing activity, 445 822 multiplication, 22 Epstein-Barr virus cultured murine virion protein genes, 22 9-(1,3-dihydroxy-2-propoxymethyl)- hepatitis B surface antigen, 563 multiplication guanine eucaryotic avian infectious bronchitis virus replication, 50 helper-independent recombinant genome, 22 early antigens adenoviruses, 606 virion protein genes, 22 chemically induced cells, 372 hamster virion protein genes immunobiochemical characterization, polyomavirus large T-antigen, 587 avian infectious bronchitis virus 372 hamster embryo genome, 22 monoclonal antibodies, 372 lymphotropic papovavirus, 100 multiplication, 22 heterogeneous DNA transformation, 100 Cowpea mosaic virus disruption of latency, 174 human neural bottom-component RNA nuclear antigen measles virus replication, 489 32,000-dalton protein, 183 complete gene, 822 papaverine, 489 proteolytic processing enzyme, 183 COS-1 cells, 822 human nonneural 32,000-dalton protein deleted gene, 822 measles virus replication, 489 bottom-component RNA, 183 replication papaverine, 489 proteolytic processing enzyme, 183 9-(1,3-dihydroxy-2-propoxymethyl)- mammalian proteolytic processing enzyme guanine, 50 herpesvirus DNA molecules, 248 bottom-component RNA, 183 Escherichia coli monkey 32,000-dalton protein, 183 Harvey murine sarcoma virus simian virus 40, 623 Cytotoxicity p21 ras protein, 343 mouse cell-mediated simian virus 40, 623 Sendai virus glycoproteins, 380 transformed, 954 Fc receptors mouse kidney herpes simplex virus type 1 cytoplasm, 77 human immunoglobulin class specific- monopinocytotic vesicles, 77 Defective-interfering particles ity, 796 polyomavirus, 77 herpesvirus human immunoglobulin subclass genomes, 13 796 natural killer 13 specificity, lymphocytic choriomeningitis virus, oncogenic transformation, Feline leukemia virus 698 persistent infection, 13 gag gene vesicular stomatitis virus nucleotide sequence, 884 NIH/3T3 mouse brains, 86 Kirsten murine sarcoma virus, 439 gag-pol junction pancreatic beta Dexamethasone nucleotide sequence, 884 mouse mammary tumor virus Fibroblasts Mengovirus, 684 632 mice, 684 env mRNA proviral copy, chicken embryo rat Diabetes mellitus endogenous avian retrovirus, 748 adenovirus 12, 854 Mengovirus nonpermissive, 748 soft-agar colony-forming, 854 mice, 684 permissive, 748 mice rat transformed, 854 Mengovirus, 684 simian virus 80 D,L-a-Difluoromethylornithine Fujinami sarcoma virus, 325 mutant T antigen, 943 145 partial transformants, 325 T human cytomegalovirus replication, revertants, 325 clones, 425 9-(1,3-Dihydroxy-2-propoxymethyl)- Foot-and-mouth disease virus influenza virus, 960 guanine polypeptides Epstein-Barr virus replication, 50 biochemical map, 579 Sendai virus, 425 DNA tumor viruses transformed mouse replication K virus, 954 ribosomal protein S6 multiple proteases, 878 Vero phosphorylation, 966 Friend ecotropic virus herpes simplex virus glycoproteins, Ducks leukemias 258 avian paramyxovirus, 649 mink cell focus-inducing virus, 872 Chickens mink cell focus-inducing virus endogenous avian retrovirus Echovirus 22 leukemias, 872 nonpermissive embryo fibroblasts, virion RNA Friend leukemia virus 748 secondary structure, 641 Fv-1 host cell restriction permissive embryo fibroblasts, 748 Encephalitis unintegrated viral DNA, 271 nonpermissive embryo fibroblasts herpes simplex virus unintegrated viral DNA endogenous avian retrovirus, 748 mice, 263 Fv-1 host cell restriction, 271 permissive embryo fibroblasts mice Friend mink cell focus-inducing virus VOL. 50, 1984 SUBJECT INDEX v

molecularly cloned DNA DNA binding, 645 Immunoglobulins env gene, 813 genetic mapping, 645 human long terminal repeat, 813 identification, 645 class, 796 Friend virus encephalitis Fc receptors, 796 induction of paralysis mice, 263 herpes simplex virus type 1, 796 murine leukemia virus, 970 glycoprotein gB subclass, 796 rats, 970 immunogenicity, 805 Influenza A virus murine leukemia virus protective immunity, 805 hemagglutinin induction of paralysis, 970 glycoprotein gC influenza C virus hemagglutinin, 118 rats, 970 immunogenicity, 805 Influenza B virus rats protective immunity, 805 hemagglutinin induction of paralysis, 970 glycoproteins influenza C virus hemagglutinin, 118 murine leukemia virus, 970 proteolysis, 258 Influenza C virus Fujinami avian sarcoma virus Vero cells, 258 hemagglutinin fps-encoded proteins immediate early gene influenza A virus hemagglutinin, 118 transforming protein, 572 transcription, 708 influenza B virus hemagglutinin, 118 monoclonal antibodies mice Influenza virus transforming protein, 572 encephalitis, 263 alveolar macrophage phagocytosis transforming protein proteolysis immune complexes, 287 fps-encoded proteins, 572 glycoproteins, 258 A/USSR/90/77 monoclonal antibodies, 572 Vero cells, 258 neuraminidase gene, 654 Fujinami sarcoma virus thymidine kinase gene B cell mitogens partial transformants amino terminus, 733 T cell-independent, 960 rat fibroblasts, 325 catalytic activity, 733 immune complexes rat fibroblasts deletions, 733 alveolar macrophage phagocytosis, partial transformants, 325 intact viral genome, 733 287 revertants, 325 T-lymphocyte subsets, 56 macrophages revertants type 1 alveolar, 287 rat fibroblasts, 325 Fc receptors, 7% immune complexes, 287 human immunoglobulin class specific- phagocytosis, 287 ity, 796 phagocytosis Gel electrophoresis human immunoglobulin subclass alveolar macrophages, 287 herpesvirus specificity, 7% immune complexes, 287 circular DNA molecules, 248 immunoglobulins, 796 T cell-independent linear DNA molecules, 248 type 2 B cell mitogens, 960 Guanidine 92,000-dalton glycoprotein, 547 Interferon resistant poliovirus mutants Vero cells 2-SA modified 37-kilodalton proteins, 922 glycoproteins, 258 vaccinia virus, 220 proteolysis, 258 gamma Herpesvirus calcium entry blockers, 964 Hamsters circular DNA molecules induction, 964 embryo cells gel electrophoresis, 248 inhibition, 964 lymphotropic papovavirus, 100 mammalian cells, 248 hybrid transformation, 100 defective-interfering particles encephalomyocarditis virus, 445 polyomavirus large T-antigen, 587 genomes, 13 retrovirus, 445 Harvey murine sarcoma virus oncogenic transformation, 13 vesicular stomatitis virus, 445 E. coli persistent infection, 13 protein kinase p21 ras protein, 343 gel electrophoresis vaccinia virus, 229 photoaffinity labeling circular DNA molecules, 248 recombinant human leukocyte p21 ras protein, 343 linear DNA molecules, 248 encephalomyocarditis virus, 445 p21 ras protein linear DNA molecules retrovirus, 445 E. coli, 343 gel electrophoresis, 248 vesicular stomatitis virus, 445 photoaffinity labeling, 343 mammalian cells, 248 vaccinia virus Hemagglutinin mammalian cells 2-SA, 220 influenza A virus, 118 circular DNA molecules, 248 protein kinase, 229 influenza B virus, 118 linear DNA molecules, 248 Intracisternal A-particles influenza C virus, 118 Herpesvirus saimiri genes Hepatitis B virus nononcogenic variant long terminal repeat sequences, 352 antigens deletion of DNA sequences, 662 M. caroli, 352 simian virus 40 vector, 335 Human adenovirus 12 molecular cloning, 352 cultured murine cells early region 1B M. caroli, 352 surface antigen, 563 host range mutant, 132 simian virus 40 vector Human adenovirus 5 antigens, 335 early region 1A Japan surface antigen N-terminal sequences, 30 avian paramyxovirus, 649 cultured murine cells, 563 peptide maps, 30 gene transcription, 563 Human cytomegalovirus Kirsten murine sarcoma virus presurface region, 563 D,L-a-difluoromethylornithine revertant NIH/3T3 cells Herpes simplex virus replication, 145 phenotypic reversion, 439 acyclovir resistance loci, 838 replication viral oncogene, 439 antiidiotype modulation of infection D,L-a-difluoromethylornithine, 145 transformed nonproducer NIH/3T3 cells increased pathogenicity, 951 Hyperlipidemia phenotypic reversion, 439 capsid protein avian leukosis virus, 301 viral oncogene, 439 vi SUBJECT INDEX J. VIROL.

K virus human nonneural cells, 489 transformed cells mouse cells papaverine, 489 K virus, 954 transformed, 954 Mengovirus vesicular stomatitis virus nononcogenic murine papovavirus, 954 diabetes mellitus, 684 defective-interfering particles, 86 T antigen mice RNA, 86 transformed mouse cells, 954 pancreatic beta cells, 684 Mink cell focus-forming virus transformed mouse cells pancreatic beta cells AKR T antigen, 954 mice, 684 conserved single-copy xenotrope-like viral DNA, 954 Mice provirus, 432 viral DNA AKR/J recombinant long terminal repeat se- transformed mouse cells, 954 murine leukemia virus, 155 quences, 432 preleukemic thymuses, 155 recombinant alphavirus murine leukemia virus, 864 Leukemia abortogenic, 66 Mink cell focus-inducing virus Friend ecotropic virus, 872 immunity, 73 Friend ecotropic virus mink cell focus-inducing virus, 872 in utero infections, 66 leukemias, 872 myeloproliferative sarcoma virus, 717 non-abortogenic, 66 leukemias Liver brains Friend ecotropic virus, 872 woodchuck hepatitis virus vesicular stomatitis virus, 86 Moloney murine sarcoma virus integrated sequences, 832 CBA/J comparison with myeloproliferative sar- Lymphocytes second-backcross progeny, 359 coma virus mouse antigens street rabies virus, 359 heteroduplex analysis, 725 endogenous xenotropic murine leuke- cell cytoplasm nucleotide sequencing, 725 mia virus, 237 simian virus 40, 623 Monkeys T cell nucleus B-lymphotropic papovavirus herpes simplex virus, 56 simian virus 40, 623 origin of replication, 451 subsets, 56 cells cell cytoplasm Lymphocytic choriomeningitis virus transformed, 954 simian virus 40, 623 infected cells central nervous systems cell nucleus lysis, 698 poliovirus 2, 137 simian virus 40, 623 natural killer cells, 698 diabetes mellitus Monopinocytotic vesicles rejection mechanism, 698 Mengovirus, 684 mouse kidney cell cytoplasm natural killer cells encephalitis polyomavirus, 77 infected cells, 698 herpes simplex virus, 263 polyomavirus rejection mechanism, 698 encephalomyocarditis virus mouse kidney cell cytoplasm, 77 uninfected cells, 698 resistance to diabetogenic effect, 684 Mouse mammary tumor virus rejection mechanism endogenous xenotropic murine leuke- dexamethasone infected cells, 698 mia virus env mRNA proviral copy, 632 natural killer cells, 698 lymphocyte antigens, 237 env mRNA uninfected cells, 698 herpes simplex virus dexamethasone, 632 uninfected cells encephalitis, 263 proviral copy, 632 lysis, 698 HRS/J genes natural killer cells, 698 murine leukemia virus, 397 asymmetric transcription, 60 rejection mechanism, 698 thymic lymphomas, 397 Murine cytomegalovirus Lymphomas in utero infections mapping of viral RNA thymic abortogenic alphavirus, 66 synthesis at immediate early times, HRS/J mice, 397 non-abortogenic alphavirus, 66 784 murine leukemia virus, 397 kidney cells transcription cytoplasm, 77 temporal regulation, 784 monopinocytotic vesicles, 77 Murine leukemia virus Macrophages polyomavirus, 77 AKR/J mice alveolar lymphocyte antigens free recombinant DNA, 155 immune complexes, 287 endogenous xenotropic murine leuke- integrated recombinant DNA, 155 influenza virus, 287 mia virus, 237 preleukemic thymuses, 155 phagocytosis, 287 Mengovirus recombinant DNA, 155 Measles virus diabetes mellitus, 684 DNA segments cDNA clone pancreatic beta cells, 684 nucleotide sequence analysis, 864 phosphoprotein, 939 organ infection recombinant mink cell focus-forming human neural cells polyomavirus, 779 virus, 864 human nonneural cells, 489 pancreatic beta cells ecotropic papaverine, 489 Mengovirus, 684 HRS/J mice, 397 replication, 489 poliovirus 2 thymic lymphomas, 397 human nonneural cells genetic changes, 137 endogenous xenotropic papaverine, 489 polyomavirus mouse lymphocyte antigens, 237 replication, 489 eventual site of persistent infection, free recombinant DNA papaverine 541 AKR/J mouse preleukemic thymuses, human neural cells, 489 organ infection, 779 155 human nonneural cells, 489 primary site of replication, 541 Friend virus replication, 489 pregnancy induction of paralysis, 970 phosphoprotein alphavirus immunity, 73 rats, 970 cDNA clone, 939 SJL/J HRS/J mice replication second-backcross progeny, 359 thymic lymphomas, 397 human neural cells, 489 street rabies virus, 359 induction of paralysis VOL. 50, 1984 SUBJECT INDEX vii

Friend virus, 970 immune complexes, 287 Protein kinase rats, 970 influenza virus, 287 interferon integrated recombinant DNA immune complexes vaccinia virus, 229 AKR/J mouse preleukemic thymuses, alveolar macrophages, 287 vaccinia virus 155 influenza virus, 287 interferon, 229 polytropic influenza virus Proteolysis HRS/J mice, 397 alveolar macrophages, 287 herpes simplex virus glycoproteins thymic lymphomas, 397 immune complexes, 287 Vero cells, 258 rats macrophages Friend virus, 970 alveolar, 287 induction of paralysis, 970 immune complexes, 287 Rabies virus recombinant DNA influenza virus, 287 leader RNA AKR/J mouse preleukemic thymuses, Photoaffinity labeling host La protein interactions, 773 155 Harvey murine sarcoma virus nucleotide sequence, 773 free, 155 p21 ras protein, 343 saturable binding sites, 691 integrated, 155 Picornavirus Rats recombinant mink cell focus-forming vi- proteins adenovirus 12 rus, 864 systematic nomenclature, 957 soft-agar colony-forming cells, 854 replication, 316 Plasmids transformed cells, 854 thymic lymphomas transformation fibroblasts HRS/J mice, 397 bacteriophage T4 gol site, 555 Fujinami sarcoma virus, 325 viral polypeptides, 316 Poliovirus partial transformants, 325 Murine papovavirus ATP revertants, 325 nononcogenic RNA synthesis in vitro, 515 Friend virus K virus, 954 genome-linked protein paralysis, 970 Murine sarcoma virus RNA synthesis in vitro, 515 Fujinami sarcoma virus temperature-sensitive transformation guanidine-resistant mutants fibroblasts, 325 mutant modified 37-kilodalton proteins, 922 partial transformants, 325 S1 nuclease mapping of viral RNAs, in vitro translation of RNA revertants, 325 478 internal initiation sites, 507 murine leukemia virus Mus caroli reticulocyte lysate, 507 paralysis, 970 intracisternal A-particles, 352 reticulocyte lysate paralysis Myeloproliferative sarcoma virus in vitro translation of RNA, 507 Friend virus, 970 characterization, 717 RNA synthesis in vitro murine leukemia virus, 970 comparison with Moloney murine sar- ATP, 515 soft-agar colony-forming cells coma virus genome-linked protein, 515 adenovirus 12, 854 heteroduplex analysis, 725 tyrosine-phosphate linkage, 515 transformed cells nucleotide sequencing, 725 tyrosine-phosphate linkage adenovirus 12, 854 leukemia, 717 RNA synthesis in vitro, 515 Respiratory syncytial virus molecular cloning, 717 Poliovirus 2 matrix protein temperature-sensitive mutants genetic changes gene nucleotide sequence, 92 characterization, 717 mouse central nervous systems, 137 Reticulocyte lysate molecular cloning, 717 mice internal initiation sites central nervous systems, 137 poliovirus RNA, 507 Polyomavirus poliovirus RNA Neuraminidase DNA molecule internal initiation sites, 507 influenza virus A/USSR/9On7, 654 nonrandom integration, 678 Retrovirus Non-immunoglobulin plasma protein random integration, 678 gene expression bovine leukemia virus, 267 repetitive cellular sequences, 678 DNA transfection of cells, 417 Nuclear polyhedrosis virus DNA virus genomes infection of cells, 417 A. californica mouse organ infection, 779 genome early transcripts, 497 large T-antigen fluidity, 759 late transcripts, 497 61,000-dalton truncated, 587 hybrid interferon transcripts, 739 transformed hamster cells, 587 antiviral activity, 445 mice protein-inducing activity, 445 eventual site of persistent infection, interferon Papaverine 541 hybrid, 445 human neural cells organ infection, 779 recombinant human leukocyte, 445 measles virus replication, 489 primary site of replication, 541 recombinant human leukocyte interfer- human nonneural cells monopinocytotic vesicles on measles virus replication, 489 mouse kidney cell cytoplasm, 77 antiviral activity, 445 measles virus mouse kidney cell cytoplasm protein-inducing activity, 445 human neural cells, 489 monopinocytotic vesicles, 77 recovered vectors human nonneural cells, 489 RNA virus genomes exogenous DNA with promoters, 42 replication, 489 mouse organ infection, 779 high-frequency deletion, 42 Papovavirus transformed hamster cells RNA tumor viruses lymphotropic large T-antigen, 587 ribosomal protein S6 hamster embryo cell transformation, Poxviruses phosphorylation, 966 100 tumorigenic Rotavirus monkey B-lymphotropic Shope fibroma virus genome, 408 immune response origin of replication, 451 Protease local, 947 Phagocytosis foot-and-mouth disease virus systemic, 947 alveolar macrophages replication, 878 viral replication viii SUBJECT INDEX J. VIROL.

kinetics, 947 DNA-binding properties, 943 Vaccinia virus Royal pastel mink simian virus 40-transformed human cell 2-SA Aleutian disease virus line interferon, 220 low virulence, 38 mutant T antigen, 943 interferon T antigen 2-SA, 220 DNA-binding properties, 943 protein kinase, 229 Sendai virus mutant, 943 protein kinase glycoproteins S1 nuclease interferon, 229 cell-mediated cytotoxicity, 380 murine sarcoma virus temperature-sen- replication T-cell clones, 425 sitive transformation mutant 2-SA, 220 Shope fibroma virus mapping of viral RNAs, 478 interferon, 220 genome Street rabies virus structural elements complete physical map, 408 CBA/J mice disulfide-linked proteins, 929 Simian herpesvirus SA8 allelic resistance genes, 359 DNA-binding proteins, 929 replication, 316 genetic analysis, 359 Varicella-zoster virus viral polypeptides, 316 resistance, 359 physical maps of DNA Simian rotavirus SAl second-backcross progeny, 359 restriction enzymes, 615 neutralization antigen murine resistance restriction enzymes cDNA sequence, 657 allelic resistance genes, 359 physical maps of DNA, 615 primary structure, 657 CBA/J mice, 359 Vesicular stomatitis virus Simian virus 40 genetic analysis, 359 ATP P--y phosphate bond early gene transcription second-backcross progeny, 359 leader RNA, 255 late promoter region, 163 SJL/J mice, 359 mRNA, 255 large T antigen SJL/J mice defective-interfering particles cellular tumor antigen p53, 457 allelic resistance genes, 359 mouse brains, 86 cytoplasmic variants, 636 genetic analysis, 359 hybrid interferon distinct phosphorylation state, 1 resistance, 359 antiviral activity, 445 DNA-binding activity, 1 second-backcross progeny, 359 protein-inducing activity, 445 nuclear variants, 636 interferon oligomeric form, 457 hybrid, 445 phosphorylation, 636 Thymidine kinase recombinant human leukocyte, 445 simian virus 40-adenovirus 7 hybrids, bacteriophage X-T4 hybrid, 619 internal deletion mutant 636 bacteriophage T4, 619 aberrant glycoprotein mRNA, 524 late promoter region herpes simplex virus leader RNA early gene transcription, 163 amino terminus, 733 ATP f3-y phosphate bond, 255 small T antigen catalytic activity, 733 mice monkey cell cytoplasm, 623 deletions, 733 brains, 86 monkey cell nucleus, 623 intact viral genome, 733 defective-interfering particles, 86 mouse cell cytoplasm, 623 TonA protein RNA, 86 mouse cell nucleus, 623 coliphage T5 mRNA temperature-sensitive BC mutants DNA ejection process, 213 ATP 13-y phosphate bond, 255 accumulation of capsid-chromatin free recombinant human leukocyte interfer- complexes, 471 coliphage T5 DNA ejection process, on block in virion assembly, 471 213 antiviral activity, 445 capsids, 471 liposome-associated protein-inducing activity, 445 chromatin, 471 coliphage T5 DNA ejection process, RNA transformed human cell line simian vi- 213 mouse brains, 86 rus 80 Tumors mutant T antigen, 943 bovine leukemia virus, 275 vector recovered avian sarcoma virus, 904 hepatitis B antigens, 335 Woodchuck hepatitis virus viral structural proteins integrated sequences subcellular distribution, 363 UV irradiation chronically infected liver, 832 Simian virus 80 bacteriophage T4 cloning, 832 mutant T antigen in vivo encapsidation of DNA, 293 structural analysis, 832 1984 APPLICATION FOR FULL MEMBERSHIP IN THE AMERICAN SOCIETY FOR MICROBIOLOGY 1913 1 Street, NW * Washington, DC 20008 0 (202) 833-9680 COMPLETE ALL INFORMATION REQUESTED AND RETURN FORM WITH REMITTANCE IN U.S. FUNDS Eligibility ASM welcomes to full membership anyone who is interested in its objectives and has a minimum of a bachelors degree orequivalentin microbiology ora related field. 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