JOURNAL OF VIROLOGY VOLUME 50 0 JUNE 1984 * NUMBER 3 Edward M. Scolnick, Editor in Chief (1987) Merck Sharp & Dohme Research Laboratories West Point, Pa. David T. Denhardt, Editor (1987) Harold S. Ginsberg, Editor (1984) Michael B. A. Oldstone, Editor (1988) University of Western Ontario Columbia University Scripps Clinic & Research Foundation London, Ontario, Canada New York, N.Y. La Jolla, Calif. Bernard N. Fields, Editor (1988) Robert M. Krug, Editor (1987) Robert A. Weisberg, Editor (1988) Harvard Medical School Sloan-Kettering Institute National Institute of Child Health and Boston, Mass. New York, N.Y. Human Development Bethesda, Md. EDITORIAL BOARD David Baltimore (1984) Hidesaburo Hanafusa (1986) Bernard Moss (1986) Bart Sefton (1985) Amiya K. Banerjee (1985) William S. Hayward (1984) Fred Murphy (1986) Phillip A. Sharp (1985) Andrew Becker (1985) Martin Hirsch (1986) Nancy G. Nossal (1984) Thomas E. Shenk (1984) Tamar Ben-Porat (1984) John J. Holland (1984) Abner Notkins (1986) Charles J. Sherr (1984) Kenneth I. Berns (1985) Ian H. Holmes (1986) J. Thomas Parsons (1986) Saul J. Silverstein (1985) Michael Botchan (1986) Robert W. Honess (1986) Ulf G. Petterson (1986) Lee D. Simon (1984) David Botstein (1985) Nancy Hopkins (1986) Lennart Philipson (1984) Ann Skalka Dennis T. Brown (1984) Peter M. Howley (1984) Lewis I. Pizer (1984) (1985) Ahmad I. Bukhari (1984) Alice S. Huang (1984) Craig R. Pringle (1986) Patricia G. Spear (1984) Barrie J. Carter (1984) Tony Hunter (1986) Carol Prives (1986) Nat Sternberg (1986) Purnell Choppin (1986) Masayori Inouye (1985) Robert Purcell (1986) Mark F. Stinski (1986) John M. Coffin (1986) Robert Kamen (1985) Fred Rapp (1984) F. William Studier (1984) Geoffrey M. Cooper (1984) Thomas J. Kelly, Jr. (1985) Dan S. Ray (1986) Lawrence S. Sturman (1985) Richard Courtney (1986) George Khoury (1984) M. E. Reichmann (1985) Jesse Summers (1985) Walter Doerfler (1986) Elliott Kieff (1984) Gordon M. Ringold (1984) William Summers (1985) Peter Dougherty (1986) Jonathan A. King (1984) Harriet Robinson (1985) John M. Taylor (1984) Harrison Echols (1984) Daniel Kolakofsky (1986) William S. Robinson (1986) Howard M. Temin (1985) Elvera Ehrenfeld (1986) Robert Lamb (1985) Bernard Roizman (1985) George F. Vande Woude (1986) Robert N. Eisenman (1985) Robert A. Lazzarini (1984) Naomi Rosenberg (1986) Inder Verma (1986) Suzanne U. Emerson (1986) Myron Levine (1985) Roland R. Rueckert (1985) Edward K. Wagner (1986) S. Jane Flint (1984) Douglas R. Lowy (1986) Norman P. Salzman (1984) Eckard Wimmer (1985) Yasuhiro Furuichi (1985) Robert Martin (1984) Joseph Sambrook (1985) Owen Witte (1986) Costa Georgopolous (1986) Thomas Merigan (1986) Charles E. Samuel (1986) Charles Hamish Young (1986) Walter Gerhard (1986) George Miller (1984) Priscilla A. Schaffer (1984) Julius S. Youngner (1986) Larry M. Gold (1985) Lois K. Miller (1985) Sondra Schlesinger (1986) Peter Gruss (1985) Peter Model (1986) June R. Scott (1986) Helen R. Whiteley, Chairman, Publications Board Walter G. Peter III, Director of Publications Linda M. Illig, Managing Editor, Journals Paula R. Ellison, Production Editor The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 I St., NW, Washington, DC 20006, is devoted to the dissemination offundamental knowledge concerning viruses of bacteria, plants, and animals. Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry, biophysics, genetics, immunology, morphology, physiology, and pathogenesis and immunity. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Department. The Journal is issued monthly, four volumes per year. The nonmember subscription price is $249 per year; single copies are $21. The member subscription price is $37 (foreign, $49 [surface rate]) per year; single copies are $7.00. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 I St., NW, Washington, DC 20006 (phone: 202 833-9680). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because offailure to report an address change or for issues "missing from files" will not be allowed. Second-class postage paid at Washington, DC 20006, and at additional mailing offices. POSTMASTER: Send address changes to Journal of Virology, ASM, 1913 I St., NW, Washington, DC 20006. Made in the U.S.A. Copyright © 1984, American Society for Microbiology. a* MIfUXtA, E I J; IIIJ4 All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the arti- cle may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center, 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index Adachi, Akio, 813 Facchini, Jole, 964 Kumel, Gunter, 805 Rozenblatt, Shmuel, 939 Adler-Storthz, Karen, 951 Faulkner, Peter, 739 Kurilla, Michael G., 773 Rueckert, Roland R., 957 Allen, Rae, 748 Fischer, Duncan K., 822 Anders, E. Margot, 960 Fukui, Yasuhisa, 854 Anderson, Dwight L., 766 Fukui, Yoshiko, 854 Laprevotte, Ivan, 884 Saito, Izumu, 854 Anderson-Sillman, Kathleen, 922 Furuta, Takahisa, 970 Larder, Brendan A., 838 Sakai, Koji, 813 Arbuthnott, Carolyn, 725 Legault-Demare, Jean, 671 Sangar, D. V., 878 Austin, M., 684 Levine, Myron, 805 Scalzo, Anthony A., 960 Galibert, Francis, 884 Schroder, Claus H., 805 Glorioso, Joseph, 805 Scott, Miller O., 895 Bartal, Sharon, 922 Grubb, Anders, 7% Shedd, Duane, 822 Baumann, Ernst, 943 Gruss, Claudia, 943 Mak, Tak W., 759 Sheridan, John F., 947 Bellini, William J., 939 Matsuyama, Mutsushi, 813 Sherr, Charles J., 884 Bernards, Rend, 847 Mayer, Bruce J., 904 Shimojo, Hiroto, 854 Billiau, A., 878 McClintock, P. R., 684 Shiroki, Kazuko, 854 Biron, Christine A., 698 Habu, Sonoku, 698 Miller, George, 822 Silver, Jonathan, 872 Bjornsti, Mary-Ann, 766 Hallberg, Torgny, 796 Morishima, T., 684 Smadja-Joffe, Florence, 717 Blenis, John, 966 Halpern, M. E., 733 Murphy, Frederick A., 779 Smiley, J. R., 733 Blomberg, Jonas, 7% Hampe, Annie, 884 Stacey, Alexander, 725 Burns, John W., Sr., 951 Hashimoto, Seiji, 854 Stocking, Carol, 717 Burroughs, J. N., 878 Henkel, Richard D., 951 Stow, Nigel D., 708 Holloway, Brian P., 773 Nakanishi, Shigetada, 813 Summers, Jesse, 832 Houweling, Ada, 847 Neckameyer, Wendi S., 914 Szczesiul, Mark, 805 Cabradilla, Cirilo D., 773 Hulen, Christian, 671 Nepveu, Alain, 678 Capobianchi, Maria R., 964 Humphries, Eric H., 748 Niwa, Ohtsura, 813 Chartrand, Pierre, 678 Norris, David, 895 Takemoto, Kenneth K., 954 Churcher, Mark J., 838 Notkins, A. L., 684 Tershak, Daniel R., 922 Clark, Stephen P., 759 Ichihashi, Yasuo, 929 Tsuruhara, Takashi, 929 Clarke, B. E., 878 Ishimoto, Akinori, 813 Coggins, Lesley, 725 Oie, Masayasu, 929 Collen, D., 878 Okumura, Ko, 698 Vaessen, Marie-Josee, 847 Cordingley, Mike G., 708 Johansson, P. J. Hugo, 796 Ostertag, Wolfram, 717, 725 van der Eb, Alex J., 847 Oxelius, Vivi-Anne, 796 Villarreal, Luis P., 779 Vonderfecht, Steven L., 947 Darby, Graham, 838 Kai, Kazushige, 970 de Leeuw, Mike G. W., 847 Kanda, Tadahito, 954 Dianzani, Ferdinando, 964 Kato, Hiroyuki, 854 Preston, Chris M., 708 Wallenburg, John C., 678 Dreesman, Gordon R., 951 Keene, Jack D., 773 Wang, Lu-Hai, 904, 914 Dubensky, Thomas W., 779 Keil, Gunther M., 784 Weigel, Ronald J., 822 Kennedy, Ronald C., 951 Reagan, Kevin J., 691 Welsh, Raymond M., 698 Khan, Arifa S., 864 Reilly, Bernard E., 766 White, David O., 960 Ebeling-Keil, Angelika, 784 Kimelman, David, 895 Ricciardi, Robert P., 895 Wimmer, Eckard, 957 Edelstein, Brian, 904 Kitamura, Naomi, 813 Richardson, Chris D., 939 Wunner, William H., 691 Enders, Lynn D., 947 Knippers, Rolf, 943 Robert, Marie F., 822 Englund, George, 939 Kollek, Regine, 717, 725 Rogler, Charles E., 832 Erikson, R. L., 966 Koprowski, Hilary, 691 Rohel, Dennis Z., 739 Yolken, Robert H., 947 Eydelloth, Ronald S., 947 Koszinowski, Ulrich H., 784 Rowlands, D. J., 878 Yoon, J. W., 684 AUTHOR INDEX VOLUME 50 Aaronson, Robert P., 118 Cordingley, Mike G., 708 Gregoire, Diane, 275 Klempnauer, Karl-Heinz, 280 Abidi, Tanveer F., 380 Couez, Dominique, 275 Griffith, Gary R., 77 Knippers, Rolf, 943 Adachi, Akio, 813 Crawford, Lionel V., 457 Grodzicker, Terri, 598 Kobayashi, Susumu, 649 Adler-Storthz, Karen, 951 Creager, Richard S., 118 Grubb, Anders, 7% Kollek, Regine, 717, 725 Allen, Rae, 748 Cuypers, Theo, 432 Grubman, Marvin J., 579 Koomey, J. Michael, 662 Anders, E. Margot, 960 Gruss, Claudia, 943 Kopchick, John, 271 Anderson, Carl W., 387 Darby, Graham, 838 Gupta, Phalguni, 267 Koprowski, Hilary, 691 Anderson, Dwight L., 766 Dasgupta, Asim, 515 Koszinowski, Ulrich H., 784 Anderson-Siliman, Kathleen, 922 Dauenhauer, Steven A., 13 Habu, Sonoku,