Preventing & Treating CANCER in PETS ••••••••••••••••••••••••••••
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Tumors of the Bone Marrow
Tumors of the Bone Marrow 803-808-7387 www.gracepets.com These notes are provided to help you understand the diagnosis or possible diagnosis of cancer in your pet. For general information on cancer in pets ask for our handout “What is Cancer”. Your veterinarian may suggest certain tests to help confirm or eliminate diagnosis, and to help assess treatment options and likely outcomes. Because individual situations and responses vary, and because cancers often behave unpredictably, science can only give us a guide. However, information and understanding for tumors in animals is improving all the time. We understand that this can be a very worrying time. We apologize for the need to use some technical language. If you have any questions please do not hesitate to ask us. What is the bone marrow? The bone marrow is the soft tissue inside the bones. Before birth, the marrow contains the primary (stem) cells from which all red and white blood cells will be formed. After birth some types of blood cells, particularly lymphocytes, are made in other parts of the body but the marrow remains the main site for production of circulating blood elements including platelets (which are vital to stop bleeding and make the blood clot), red cells (which carry oxygen) and most white cells (which fight infections and clear up debris). What type of tumors are found in the bone marrow? Tumors of the blood cells made in the marrow are rare. There is a continuum from dysplasias (abnormal growths) to cancers (myeloproliferative disease). Malignant tumors of the blood vessels within the marrow (hemangiosarcomas) are relatively common in dogs although the clinical disease usually shows elsewhere first. -
A Deadly Virus Makes a Comeback
AnimalNEWS 19.1 A DEADLY VIRUS MAKES A COMEBACK Fur Seals Help Researchers Understand Ocean Life Cancer Research: Looking Back, Moving Forward 2019 Dog & Cat Studies For more than 70 years, Morris Animal YOUR Foundation has been a global leader in funding studies to advance animal American German Shepherd health. With the help of generous GIFTS IN donors like you, we are improving the health and well-being of dogs, cats, Dog Charitable Foundation ACTION horses and wildlife worldwide. PARTNERS IN RESEARCH AND EDUCATION IN THIS ISSUE 2 Your Gifts in Action In 2007, the American German Shepherd Dog Over the years, they have 3 Partners in Research Charitable Foundation Inc. (AGSDCF) made its first gift to support canine health studies at Morris funded research projects in hip 4 Fur Seals Help Researchers dysplasia, genetics of bloat, Animal Foundation. Since then, the organization has canine epilepsy, musculoskeletal 6 It’s More Fun with Goldens continued its investment in research, particularly in conditions and, more recently, 7 Feline Panleukopenia health concerns for the German shepherd. hemangiosarcoma, an almost universally fatal 8 Cancer Research Heart Drug’s Variability cancer in dogs. But this year, they decided to 10 Dog & Cat Health Studies Between 6 and 17 percent of cats with cardiac diseases develop potentially life- invest in veterinary students, While they continue to actively 11 Our New CSO and CDO threatening blood clots. The anticlotting drug clopidogrel, also known as Plavix, is often prescribed to prevent clots from forming. However, veterinarians have been too, and made a gift of fund research, the organization perplexed why some cats respond to treatment and others do not. -
Issue 53 • Fall/Winter 2015 Check out Our Fresh Newsletter Design!
AKC Canine Health Foundation Issue 53 • Fall/Winter 2015 THIS ISSUE AT A GLANCE Dr. Douglas Thamm Receives Asa Mays, DVM Award ............3 CHF Welcomes New CSO .........5 CHF & VetVine Team Up for Webinar Series ..........................6 Distinguished Research Partners to be Honored ........................... 7 2015 National Parent Club Canine Health Conference Recap ..........................................8 Labrador Retriever Club, Inc., to Receive President’s Award ....10 Cold Weather Canine Care ...10 Your Impact: Spontaneous Cancer in Dogs ........................13 Check out our fresh newsletter design! © Copyright 2015 AKC Canine Health Foundation. All rights reserved. Dear Canine Health Supporter: This year, we celebrate the 20th anniversary of the AKC Canine Health Foundation (CHF), a milestone that would not be possible without your commitment to the health of all dogs. Thanks to you, the dogs we love benefit from advances in veterinary medicine, receiving better treatment options and more accurate diagnoses for both common and complex health issues. From laying the groundwork that mapped the canine genome, to awarding grants that eventually led to genetic tests for conditions like Exercise-Induced Collapse and Von Willebrand’s Disease; from working collaboratively with researchers to bring about better understanding and more effective treatments for diseases like cancer, epilepsy and bloat, to being on the forefront of new, promising breakthroughs like stem cell research/regenerative medicine, anti-viral therapy and personalized medicine, your support of CHF has made these breakthroughs possible. As we look toward the future, your gift to CHF is as important as ever. By donating and continuing your commitment to canine health, you help build on the important scientific advances in veterinary medicine and biomedical science, impacting future generations of dogs. -
Canine Breed Predisposition to Cancer
Canine Breed Predisposition to Cancer 1Amalia Saladrigas, 1Adrienne Thom, 2Amanda Koehne, DVM 1Stanford University (Class of 2016), 2Cancer Biology Program, Stanford School of Medicine Introduction Osteosarcoma: large breeds Lymphoma: Golden Retriever Particularly now that pets are living longer, cancer has become a leading 1 cause of death in dogs. Cancer can affect all breeds of dogs, but there are General Information: General Information: some breeds that appear to be at higher risk to certain types of cancer. • Most common primary bone tumor in dogs • Most common tumor of the hematopoietic system in dogs Given the similarities between many human and canine cancers, the domestic • The mean age is 7 years7 • Classification of canine lymphomas follows a similar classification 2 13 dog has been used as a model of spontaneous neoplasia. • It occurs in large and giant breed dogs: Doberman, German Shepherd, Golden scheme to that used for humans Retriever, Great Dane, Irish Setter, Rottweiler and Saint Bernard8 • Golden Retrievers are predisposed • Higher incidence in middle-aged dogs (6-7 years)14 Histiocytic Sarcoma: Bernese Clinical Manifestation: Mountain Dog • Occurs in the metaphysis of long bones, similar to disease in humans Clinical Manifestation: • Most common in proximal humerus, distal femur, and proximal tibia • Clinical signs are highly variable and reflect the organs involved General Information: • Metastasis usually to lungs and other bones • Lymphadenopathy, anorexia, and lethargy are common • Mean age of onset is 6.5 years -
Cat Health Check 2020 No Price
Feline Health Check Program At Napanee Veterinary Hospital, we are always looking for better tools to help pet owners take care of their pets’ health. This is why we are proud to present our Health Check Program. This program offers health screening that will help us provide the best possible care for your pets. 1. FIV/FeLV Snap Test: -FIV, or Feline Immunodeficiency Virus, is a virus that cats can catch when they go outdoors, especially if they tend to fight with other cats. This virus is similar to the HIV virus in humans. As with humans with HIV, cats with FIV may not show symptoms for many years. There is no cure for FIV, but once we know a cat is infected, we can manage their healthcare accordingly. -FeLV, or Feline Leukemia Virus, is a virus that can cause cancer in cats, as well as immune system deficiencies. Cats can get FeLV, through direct or indirect contact with other cats (for example sharing bowls or grooming). Kittens can also get it from their mom. As with FIV, infected cats may not show symptoms for many years. There is no cure for FeLV, but once we know a cat is infected, we can manage their healthcare accordingly. 2. Early Detection Blood Screening: This test will measure your cat’s blood glucose, as well as specific blood enzymes that give us information on the health and function of the liver and kidneys. Animals that are 7 years or older will also have their thyroid tested and blood cells checked. The goal of this test is to detect subtle anomalies that may not be severe enough to make the animal sick, but allows us to detect early disease and treat them early. -
Analysis of Inherited and Somatic Variants to Decipher Canine Complex Traits
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1454 Analysis of inherited and somatic variants to decipher canine complex traits KATE MEGQUIER ACTA UNIVERSITATIS UPSALIENSIS ISSN 1651-6206 ISBN 978-91-513-0310-9 UPPSALA urn:nbn:se:uu:diva-347165 2018 Dissertation presented at Uppsala University to be publicly examined in B:22, BMC, Husargatan 3, Uppsala, Monday, 21 May 2018 at 13:15 for the degree of Doctor of Philosophy (Faculty of Medicine). The examination will be conducted in English. Faculty examiner: David Sargan (University of Cambridge). Abstract Megquier, K. 2018. Analysis of inherited and somatic variants to decipher canine complex traits. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1454. 67 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0310-9. This thesis presents several investigations of the dog as a model for complex diseases, focusing on cancers and the effect of genetic risk factors on clinical presentation. In Papers I and II, we performed genome-wide association studies (GWAS) to identify germline risk factors predisposing US golden retrievers to hemangiosarcoma (HSA) and B- cell lymphoma (BLSA). Paper I identified two loci predisposing to both HSA and BLSA, approximately 4 megabases (Mb) apart on chromosome 5. Carrying the risk haplotype at these loci was associated with separate changes in gene expression, both relating to T-cell activation and proliferation. Paper II followed up on the HSA GWAS by performing a meta-analysis with additional cases and controls. This confirmed three previously reported GWAS loci for HSA and revealed three new loci, the most significant on chromosome 18. -
Cancer in Dogs
Cancer in Dogs Canine Cancer Facts FACT: Cancer is the leading cause of non-accidental death in dogs. FACT: Lymphoma is the leading cancer diagnosed in dogs. FACT: Nearly 50% of pets over the age of 10 will develop some type of cancer. FACT: The increasing incidence of cancer in dogs is due to longer life spans. What is cancer? Cancer is a single word that encompasses many different types of diseases. Each of these diseases is attributed to the purposeless and uncontrolled growth of cells on or within the body. They are either localized to one part of the body as a visible mass (tumor) or spread throughout (metastasis). Cancer can develop in or from any tissue in the body. Cancer is common in the dog or cat and the rate increases with age. Dogs get cancer at roughly the same rate as humans, while cats get fewer cancers. In one survey, cancer accounted for almost half the deaths of those pets over 10 years of age. There are many different types of cancer, each type named according to the tissue (or part of the body) that it originated. Some cancers have the ability to metastasize (spread) to other parts of the body. Other terms for cancer are malignancy and neoplasia. What causes canine cancer? No one seems to know for sure what causes cancer in our furry friends. Some theories include pesticides, preservatives and fillers used in dog foods; second hand smoke; vaccinations; chronic ehrlichiosis etc. Unfortunately, these are only theories, and have yet to be proven. Since the cause of cancer is not known, prevention is difficult. -
Mammary Gland Tumors in Cats
Mammary Gland Tumors in Cats (Breast Tumors in Cats) Basics OVERVIEW • Cancerous (malignant) and benign tumors of the breast (mammary glands) in cats • “Mammary” refers to a breast or mammary gland • The mammary glands produce milk to feed newborn kittens; they are located in two rows that extend from the chest to the inguinal area; the nipples indicate the location of the mammary glands • Most cancerous (malignant) breast tumors in cats are carcinomas; benign breast tumors in cats include adenomas, fibroadenomas, and papillomas • Spread to the lungs (known as “pulmonary metastasis”) is seen in up to 80% of cats with breast cancer; spread to the regional lymph nodes is seen in up to 50% of cats GENETICS • The high number of Siamese with breast tumors suggests a genetic component; however, specific genes have not been identified to date SIGNALMENT/DESCRIPTION OF PET Species • Cats; breast (mammary gland) tumors are the third most common type of tumor seen in cats Breed Predilections • Domestic shorthair and longhair cats are affected most commonly, but this likely reflects the popularity of these breeds, rather than a true increased likelihood of developing breast tumors as compared to other cat breeds • Siamese have twice the risk of developing breast tumors than other cat breeds Mean Age and Range • Mean—10–12 years of age • Range—9 months–23 years of age (although most cats are greater than 5 years of age) • Siamese tend to develop breast tumors at a younger age and the incidence begins to plateau around 9 years of age Predominant Sex -
Stem Cell Growth Factor Receptor in Canine Vs. Feline Osteosarcomas
ONCOLOGY LETTERS 12: 2485-2492, 2016 Stem cell growth factor receptor in canine vs. feline osteosarcomas BIRGITT WOLFESBERGER1, ANDREA FUCHS-BAUMGARTINGER2, JURAJ HLAVATY2, FLORIAN R. MEYER2, MARTIN HOFER3, RALF STEINBORN3, CHRISTIANE GEBHARD2 and INGRID WALTER2 Departments of 1Companion Animals and Horses and 2Pathobiology; 3Genomics Core Facility, VetCore, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria Received April 22, 2015; Accepted July 22, 2016 DOI: 10.3892/ol.2016.5006 Abstract. Osteosarcoma is considered the most common the cats that succumbed to disease earlier was 4 years without bone cancer in cats and dogs, with cats having a much better any adjuvant treatment (3). In cats, metastasis due to osteo- prognosis than dogs, since the great majority of dogs with sarcoma appears to be rare, with an incidence of 5-10% (2-4). osteosarcoma develop distant metastases. In search of a factor By contrast, the median survival times following the amputa- possibly contributing to this disparity, the stem cell growth tion of appendicular osteosarcomas in dogs were 3-5 months, factor receptor KIT was targeted, and the messenger (m)RNA which are relatively low, since dogs rapidly develop metastasis, and protein expression levels of KIT were compared in canine mainly to the lungs, but also to other bones (5-7). By adding vs. feline osteosarcomas, as well as in normal bone. The mRNA adjuvant chemotherapeutics such as carboplatin, cisplatin or expression of KIT was quantified by reverse transcription‑ doxorubicin subsequent to surgery, the median survival time quantitative polymerase chain reaction, and was observed to of dogs was significantly prolonged to ~1 year (8-11). -
FELINE LEUKEMIA VIRUS Pfennig Lane Animal Hospital 512-989-2222
FELINE LEUKEMIA VIRUS Pfennig Lane Animal Hospital 512-989-2222 What is feline leukemia virus? Feline leukemia virus (FeLV), a retrovirus, so named because of the way it behaves within infected cells. All retroviruses, including feline immunodeficiency virus (FIV) and human immunodeficiency virus (HIV), produce an enzyme, reverse transcriptase, which permits them to insert copies of their own genetic material into that of the cells they have infected. Although related, FeLV and FIV differ in many ways, including their shape: FeLV is more circular while FIV is elongated. The two viruses are also quite different genetically, and their protein consituents are dissimlar in size and composition. Although many of the diseases caused by FeLV and FIV are similar, the specific ways in which they are caused differs. How common is the infection? FeLV-infected cats are found worldwide, but the prevalence of infection varies greatly depending on their age, health, environment, and lifestyle. In the United States, approximately 2 to 3% of all cats are infected with FeLV. Rates rise significantly—13% or more—in cats that are ill, very young, or otherwise at high risk of infection. How is FeLV spread? Cats persistently infected with FeLV serve as sources of infection. Virus is shed in very high quantities in saliva and nasal secretions, but also in urine, feces, and milk from infected cats. Cat- to-cat transfer of virus may occur from a bite wound, during mutual grooming, and (though rarely) through the shared use of litter boxes and feeding dishes. Transmission can also take place from an infected mother cat to her kittens, either before they are born or while they are nursing. -
Mast Cell Tumors Phyllis C Glawe DVM MS Diplomate ACVIM, Oncology
Canine Mast Cell Tumors Phyllis C Glawe DVM MS Diplomate ACVIM, Oncology What is a Mast Cell Tumor? Mast Cell Tumors (MCTs) are one of the most common malignant skin tumors in dogs. Mast cells are the cells that normally are associated with allergy responses, such as the swelling and redness that occur with insect stings. In dogs, mast cell tumors typically are located in the skin of the trunk and peripheral limbs. The masses are typically solitary, reddened in color, hairless and occur in middle age/older dogs. They can be itchy and occasionally can present with ulceration on the skin surface. These tumors are malignant due to their tendency to invade deeply into the surrounding tissue and occasionally spread to other organs, such as the lymph nodes, liver and spleen. One of the more interesting features of this cancer is its behavior: MCTs may grow and shrink rapidly due to inflammation caused by mast cells occasional release of histamine and other vasoactive chemicals. How is the Diagnosis Made? The clinical appearance of MCTs can vary, however the tumors are typically relatively straightforward to diagnose with a fine needle aspiration cytology. A biopsy of tissue can also be performed to obtain the diagnosis, if cytology is not definitive. Special stains can be applied to the tissue biopsy sample to identify the cancer cells if necessary. What is meant by “Grade of the Mast cell tumor” and why is it important? “Grade” of the mast cell tumor refers to characteristics of the cancer cells noted within the tissue biopsy specimen. -
Intestinal Tumors in Dogs and Cats Comprehensive Cancer Care Service Ryan Veterinary Hospital of the University of Pennsylvania
Information for Oncology Clients Intestinal Tumors in Dogs and Cats Comprehensive Cancer Care Service Ryan Veterinary Hospital of the University of Pennsylvania Intestinal cancer is fairly uncommon in dogs and cats. Most intestinal tumors are in the large intestine (colon and rectum); although, some particular tumors (lymphoma) occur more commonly in the small intestines. Cancers that can occur in the intestines include adenocarcinoma, leiomyosarcoma, lymphoma, mast cell tumor, gastrointestinal stromal tumor (GIST), carcinoid, and rarely plasma cell tumor or hemangiosarcoma. The most common intestinal cancer in cats is lymphoma. Malignant tumors have the potential to spread to many areas of the body, including lymph nodes, other abdominal organs such as the liver, and lungs. Benign tumors, such as polyps and adenomas, can also occur. Adenomatous polyps are found more commonly in the rectum of dogs and the small intestines in cats. These benign tumors can be solitary or multiple. Even though they are benign, they can cause mechanical problems including obstruction of the intestinal tract. The majority of animals with intestinal tumors are middle-aged to older. Some research has shown that male dogs and cats have a higher likelihood of developing intestinal tumors. Siamese cats have a higher risk for adenocarcinomas and lymphoma, and cats with feline immunodeficiency virus (FIV) or feline leukemia virus (FeLV) are predisposed to developing lymphoma. Certain dog breeds, such as Collies and German Shepherds, have been shown to have an increased risk for intestinal tumors, particularly adenocarcinoma. Clinical signs usually seen with intestinal tumors include weight loss, decreased appetite, vomiting, diarrhea, and blood within the vomit or feces.