Challenges in Organic Chemistry ISACS19 #ISACS
Total Page:16
File Type:pdf, Size:1020Kb

Load more
Recommended publications
-
C9-14 Aliphatic [2-25% Aromatic] Hydrocarbon Solvents Category SIAP
CoCAM 2, 17-19 April 2012 BIAC/ICCA SIDS INITIAL ASSESSMENT PROFILE Chemical C -C Aliphatic [2-25% aromatic] Hydrocarbon Solvents Category Category 9 14 Substance Name CAS Number Stoddard solvent 8052-41-3 Chemical Names Kerosine, petroleum, hydrodesulfurized 64742-81-0 and CAS Naphtha, petroleum, hydrodesulfurized heavy 64742-82-1 Registry Solvent naphtha, petroleum, medium aliphatic 64742-88-7 Numbers Note: Substances in this category are also commonly known as mineral spirits, white spirits, or Stoddard solvent. CAS Number Chemical Description † 8052-41-3 Includes C8 to C14 branched, linear, and cyclic paraffins and aromatics (6 to 18%), <50ppmV benzene † 64742-81-0 Includes C9 to C14 branched, linear, and cyclic paraffins and aromatics (10 to Structural 25%), <100 ppmV benzene Formula † and CAS 64742-82-1 Includes C8 to C13 branched, linear, and cyclic paraffins and aromatics (15 to 25%), <100 ppmV benzene Registry † Numbers 64742-88-7 Includes C8 to C13 branched, linear, and cyclic paraffins and aromatics (14 to 20%), <50 ppmV benzene Individual category member substances are comprised of aliphatic hydrocarbon molecules whose carbon numbers range between C9 and C14; approximately 80% of the aliphatic constituents for a given substance fall within the C9-C14 carbon range and <100 ppmV benzene. In some instances, the carbon range of a test substance is more precisely defined in the test protocol. In these instances, the specific carbon range (e.g. C8-C10, C9-C10, etc.) will be specified in the SIAP. * It should be noted that other substances defined by the same CAS RNs may have boiling ranges outside the range of 143-254° C and that these substances are not covered by the category. -
BULLETIN for the HISTORY of CHEMISTRY Division of the History of Chemistry of the American Chemical Society
BULLETIN FOR THE HISTORY OF CHEMISTRY Division of the History of Chemistry of the American Chemical Society VOLUME 29, Number 1 2004 BULLETIN FOR THE HISTORY OF CHEMISTRY VOLUME 29, CONTENTS NUMBER 1 THE 2003 EDELSTEIN AWARD ADDRESS* MAKING CHEMISTRY POPULAR David Knight, University of Durham, England 1 THE DISCOVERY OF LECITHIN, THE FIRST PHOSPHOLIPID Theodore L. Sourkes, McGill University 9 GABRIEL LIPPMANN AND THE CAPILLARY ELECTROMETER John T. Stock, University of Connecticut 16 KHEMYE: CHEMICAL LITERATURE IN YIDDISH Stephen M. Cohen 21 AN EARLY HISTORY OF CHEMISTRY AT TEXAS TECH UNIVERSITY, 1925-1970* Henry J. Shine, Texas Tech University 30 NOYES LABORATORY, AN ACS NATIONAL CHEMICAL LANDMARK: 100 YEARS OF CHEMISTRY AT THE UNIVERSITY OF ILLINOIS Sharon Bertsch McGrayne 45 BOOK REVIEWS 52 The Cover…….See page 24. Bull. Hist. Chem., VOLUME 29, Number 1 (2004) 1 THE 2003 EDELSTEIN AWARD ADDRESS* MAKING CHEMISTRY POPULAR David Knight, University of Durham, England “Chemistry is wonderful,” wrote evenings, and a bright dawn Linus Pauling (1), “I feel sorry for gleamed over a chemically-based people who don’t know anything society. Intellectually, the science about chemistry. They are miss- did not demand the mathematics re- ing an important source of happi- quired for serious pursuit of the sub- ness.” That is not how the science lime science of astronomy. Chem- has universally been seen in our ists like Joseph Priestley thought it time. We would not expect to see the ideal Baconian science in which lecture-rooms crowded out, chem- everyone might join, for its theoreti- ists as stars to be invited to fash- cal structure was still unformed. -
Southwest Retort
SOUTHWEST RETORT SIXTY-NINTH YEAR OCTOBER 2016 Published for the advancement of Chemists, Chemical Engineers and Chemistry in this area published by The Dallas-Fort Worth Section, with the cooperation of five other local sections of the American Chemical Society in the Southwest Region. Vol. 69(2) OCTOBER 2016 Editorial and Business Offices: Contact the Editor for subscription and advertisement information. Editor: Connie Hendrickson: [email protected] Copy Editor: Mike Vance, [email protected] Business Manager: Danny Dunn: [email protected] The Southwest Retort is published monthly, September through May, by the Dallas-Ft. Worth Section of the American Chemical Society, Inc., for the ACS Sections of the Southwest Region. October 2016 Southwest RETORT 1 TABLE OF CONTENTS Employment Clearing House………….......3 Fifty Years Ago……………………….….....6 ARTICLES and COLUMNS Schulz Award Winner Gale Hunt………….7 And Another Thing……………………….11 Around the Area………………………….14 Letter from the Editor….…..……….........17 SPECIAL EVENTS National Chemistry Week…………………9 NEWS SHORTS Former pesticide ingredient found in dolphins, birds and fish……………………8 Coffee-infused foam removes lead from contaminated water………………………10 Snake venom composition could be related to hormones and diet……………………..13 Detecting blood alcohol content with an electronic skin patch………………...……16 INDEX OF ADVERTISERS Huffman Laboratories……………....……..4 Contact the DFW Section Vance Editing…..…………….…….……….4 General: [email protected] UT Arlington………………………………..4 Education: [email protected] ANA-LAB……………………...….…...……5 Elections: [email protected] Facebook: DFWACS Twitter: acsdfw October 2016 Southwest RETORT 2 EMPLOYMENT CLEARING HOUSE Job applicants should send name, email, and phone, along with type of position and geographical area desired; employers may contact job applicants directly. -
Personal View – the Evolution of Neurochemistry
Neuroforum 2019; 25(4): 259–264 Review Article Ferdinand Hucho* Personal View – The Evolution of Neurochemistry Two questions – one answer https://doi.org/10.1515/nf-2019-0023 century up to our times. Reductionism was hoped to solve two of the most fundamental riddles which were central to Abstract: This esssay is a personal account of the evolution human thinking since antiquity: The world, believed to be of Neurochemistry in the past century. It describes in par- composed of ‚mind and matter‘, poses the question: What allel the authors way from chemistry to biochemistry and is life? The neurochemist goes one step further and asks: finally to Neurochemistry and the progress of a most ex- what is mind (conciousness, cognition, free will)? The citing chapter of the Life Sciences. It covers the successful physiologist Emil du Bois-Reymond (1818–1896) included time period of reductionist research (by no means compre- these questions in his ‚seven riddles‘ (Finkelstein 2013) hensively), which lay the ground for the recent and future and summarized his answer in 1880 in his famous “igno- systems approach. This development promises answers to ramus et ignorabimus” (“we don‘t know and we never will fundamental questions of our existence as human beings. know”). Never say ‘never’, because this could be the end Keywords: Chemistry; Biochemistry; Life Science; Neuro- of human curiosity and research, preventing discoveries chemistry including new methods of investigation. In the 20th century the question What is life was most vividly posed by physicists like the Nobel laureates Zusammenfassung: Dieser Essay ist ein persönlicher Erwin Schrödinger (Schrödinger 1944; Fischer ed., 1987) Bericht über die Entwicklung der Neurochemie im ver- and Max Delbrück (Delbrück 1986). -
Hans Renata – Strategic Redox Relay Enables a Scalable Synthesis Of
Strategic Redox Relay Enables A Scalable Synthesis of Ouabagenin, A Bioactive Cardenolide A thesis presented by Hans Renata to The Scripps Research Institute Graduate Program in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the subject of Chemistry for The Scripps Research Institute La Jolla, California February 2013 UMI Number: 3569793 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. UMI 3569793 Published by ProQuest LLC (2013). Copyright in the Dissertation held by the Author. Microform Edition © ProQuest LLC. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code ProQuest LLC. 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, MI 48106 - 1346 © 2013 by Hans Renata All rights reserved ! ii! ACKNOWLEDGEMENTS To Phil, thank you for taking me under your wing, the past five years have been a wonderful learning experience. You truly are a fantastic teacher, both in and out of the fumehood and your unbridled enthusiasm, fearlessness and passion for chemistry are second to none. In the words of Kurt Cobain, I am “forever indebted to your priceless advice.” To the members of the Baran lab, in the words of Kurt Cobain, “Our little (?) group has always been and always will until the end.” See what I did there? Oh well, whatever, nevermind. -
Essays in Neurochemistry and Neuropharmacology Chemical
Volume 89, number 2 FEBS LETTERS May 1978 Essays in Neurochemistry and Neuropharmacology Volume 2 Edited by M. B. H. Youdim, W. Lovenberg, D. F. Sharman and J. R. Lagnado John Wiley and Sons; Chichester, New York, Brisbane, Toronto, 1977 xiv + 174 pages, £8.75 An essay on essays prefaces this book, praising the The Biochemical Society's 'Essays in Biochemistry' literary essay and advocating a comparable form of which antedate the present series by I 1 years are also scientific writing as a leavening or antidote to the despite their name broad, didactically-oriented reviews stereotype of papers proceeding by Methods-Results- in which many authors use figures and tables as a Discussion. The terse wisdom and precise word-choise means of avoiding cumbersome passages of text; a of Bacon, or the charm of Lamb, would indeed be necessary distinction from the literary essay and much welcome in the neurosciences, but this book's to be encouraged. So also are author and subject contents exemplify a different and quite worthy indexes which are lacking in the present book. It also stereotype, the review. Are literary essays ever multi- has no running titles or author's names at the head of author, as are half of the present contributions? Two its pages; and as the list of abbrevations and the of the most effective essays here are indeed single- literature references come at the beginning and end of authored: the first few pages of K. G. Walton's each individual essay, lack of this guidance to where account of cyclic necleotides and postynaptic events the beginning and end are located is to be regretted. -
The Grand Challenges in the Chemical Sciences
The Israel Academy of Sciences and Humanities Celebrating the 70 th birthday of the State of Israel conference on THE GRAND CHALLENGES IN THE CHEMICAL SCIENCES Jerusalem, June 3-7 2018 Biographies and Abstracts The Israel Academy of Sciences and Humanities Celebrating the 70 th birthday of the State of Israel conference on THE GRAND CHALLENGES IN THE CHEMICAL SCIENCES Participants: Jacob Klein Dan Shechtman Dorit Aharonov Roger Kornberg Yaron Silberberg Takuzo Aida Ferenc Krausz Gabor A. Somorjai Yitzhak Apeloig Leeor Kronik Amiel Sternberg Frances Arnold Richard A. Lerner Sir Fraser Stoddart Ruth Arnon Raphael D. Levine Albert Stolow Avinoam Ben-Shaul Rudolph A. Marcus Zehev Tadmor Paul Brumer Todd Martínez Reshef Tenne Wah Chiu Raphael Mechoulam Mark H. Thiemens Nili Cohen David Milstein Naftali Tishby Nir Davidson Shaul Mukamel Knut Wolf Urban Ronnie Ellenblum Edvardas Narevicius Arieh Warshel Greg Engel Nathan Nelson Ira A. Weinstock Makoto Fujita Hagai Netzer Paul Weiss Oleg Gang Abraham Nitzan Shimon Weiss Leticia González Geraldine L. Richmond George M. Whitesides Hardy Gross William Schopf Itamar Willner David Harel Helmut Schwarz Xiaoliang Sunney Xie Jim Heath Mordechai (Moti) Segev Omar M. Yaghi Joshua Jortner Michael Sela Ada Yonath Biographies and Abstracts (Arranged in alphabetic order) The Grand Challenges in the Chemical Sciences Dorit Aharonov The Hebrew University of Jerusalem Quantum Physics through the Computational Lens While the jury is still out as to when and where the impressive experimental progress on quantum gates and qubits will indeed lead one day to a full scale quantum computing machine, a new and not-less exciting development had been taking place over the past decade. -
Peptide Chemistry up to Its Present State
Appendix In this Appendix biographical sketches are compiled of many scientists who have made notable contributions to the development of peptide chemistry up to its present state. We have tried to consider names mainly connected with important events during the earlier periods of peptide history, but could not include all authors mentioned in the text of this book. This is particularly true for the more recent decades when the number of peptide chemists and biologists increased to such an extent that their enumeration would have gone beyond the scope of this Appendix. 250 Appendix Plate 8. Emil Abderhalden (1877-1950), Photo Plate 9. S. Akabori Leopoldina, Halle J Plate 10. Ernst Bayer Plate 11. Karel Blaha (1926-1988) Appendix 251 Plate 12. Max Brenner Plate 13. Hans Brockmann (1903-1988) Plate 14. Victor Bruckner (1900- 1980) Plate 15. Pehr V. Edman (1916- 1977) 252 Appendix Plate 16. Lyman C. Craig (1906-1974) Plate 17. Vittorio Erspamer Plate 18. Joseph S. Fruton, Biochemist and Historian Appendix 253 Plate 19. Rolf Geiger (1923-1988) Plate 20. Wolfgang Konig Plate 21. Dorothy Hodgkins Plate. 22. Franz Hofmeister (1850-1922), (Fischer, biograph. Lexikon) 254 Appendix Plate 23. The picture shows the late Professor 1.E. Jorpes (r.j and Professor V. Mutt during their favorite pastime in the archipelago on the Baltic near Stockholm Plate 24. Ephraim Katchalski (Katzir) Plate 25. Abraham Patchornik Appendix 255 Plate 26. P.G. Katsoyannis Plate 27. George W. Kenner (1922-1978) Plate 28. Edger Lederer (1908- 1988) Plate 29. Hennann Leuchs (1879-1945) 256 Appendix Plate 30. Choh Hao Li (1913-1987) Plate 31. -
Analysis of the Trends in Biochemical Research Using Latent Dirichlet Allocation (LDA)
Article Analysis of the Trends in Biochemical Research Using Latent Dirichlet Allocation (LDA) Hee Jay Kang 1, Changhee Kim 1,* and Kyungtae Kang 2,* 1 College of Business Administration, Incheon National University, 119, Academy-ro, Yeonsu-gu, Incheon 22012, Korea; [email protected] 2 Department of Applied Chemistry, Kyung Hee University, 1732, Deogyeong-daero, Giheung-gu, Yongin-si, Gyeonggi-do 130-701, Korea * Correspondence: [email protected] (C.K.); [email protected] (K.K.); Tel.: +82-2-880-8594(C.K.) Received: 15 April 2019; Accepted: 13 June 2019; Published: 18 June 2019 Abstract: Biochemistry has been broadly defined as “chemistry of molecules included or related to living systems”, but is becoming increasingly hard to be distinguished from other related fields. Targets of its studies evolve rapidly; some newly emerge, disappear, combine, or resurface themselves with a fresh viewpoint. Methodologies for biochemistry have been extremely diversified, thanks particularly to those adopted from molecular biology, synthetic chemistry, and biophysics. Therefore, this paper adopts topic modeling, a text mining technique, to identify the research topics in the field of biochemistry over the past twenty years and quantitatively analyze the changes in its trends. The results of the topic modeling analysis obtained through this study will provide a helpful tool for researchers, journal editors, publishers, and funding agencies to understand the connections among the diverse sub-fields in biochemical research and even see how the research topics branch out and integrate with other fields. Keywords: biochemistry; topic modeling; research trend; LDA 1. Introduction Biochemistry is the study of the structure, composition, and chemical reactions of substances in living systems and includes the sciences of molecular biology, immunochemistry, and neurochemistry, as well as bioinorganic, bioorganic, and biophysical chemistry [1]. -
Identification of a Thioesterase Bottleneck in the Pikromycin Pathway Through Full-Module Processing of Unnatural Pentaketides
Article pubs.acs.org/JACS Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides † ‡ † § † ‡ ⊥ ∥ Douglas A. Hansen, , Aaron A. Koch, , and David H. Sherman*, , , , † ‡ § ⊥ Life Sciences Institute, Department of Medicinal Chemistry, Cancer Biology Graduate Program, Department of Chemistry, and ∥ Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States *S Supporting Information ABSTRACT: Polyketide biosynthetic pathways have been engineered to generate natural product analogs for over two decades. However, manipulation of modular type I polyketide synthases (PKSs) to make unnatural metabolites commonly results in attenuated yields or entirely inactive pathways, and the mechanistic basis for compromised production is rarely elucidated since rate-limiting or inactive domain(s) remain unidentified. Accordingly, we synthesized and assayed a series of modified pikromycin (Pik) pentaketides that mimic early pathway engineering to probe the substrate tolerance of the PikAIII-TE module in vitro. Truncated pentaketides were processed with varying efficiencies to corresponding macrolactones, while pentaketides with epimerized chiral centers were poorly processed by PikAIII-TE and failed to generate 12-membered ring products. Isolation and identification of extended but prematurely offloaded shunt products suggested that the Pik thioesterase (TE) domain has limited substrate flexibility and functions as a gatekeeper in the processing of -
Opening a New Chapter in the Martian Chronicles
California Institute of Technology Volume 2., No.• ~emlMr1"2 B•• ed on d.t. from the 1975 Viking ml ••lon , the Explore". Guide to MoIr • .... pon Arden Albee'. w a ll will be In for . ome updating once Ma ,. Ob.erve r be g in. It ••urv e v of the planet late ne xt vear. Albee ke ep. a replica of the .pacecraft In Caltech'. Office of Graduate Studle., w" .. e In addition to hi. role a. Ob.e rver project .clentl.t, he'. been dean . lnce1984. Opening a new chapter in the Martian Chronicles BV Heidi Aapaturlan Speaking this past August at a many Mars aficionados ever since the working in concert like an interplan "It's not cleat what sort of geologic NASA press conference called to herald Viking Lander's soil experimencs came etary one-man band, will monitor and dynamics might have produced this che upcoming launch of Mars Observer, up empty in 1975: has life ever map Mars with a sweep and precision dichotomy," says Albee, alchough he Cal tech Professor of Geology Arden evolved on Mars? Did the planet once that is expected to yield more informa suspects that the answer may start to Albee sounded ar rimes like a man who harbor a bacterial Atlantis that van tion abour the planer's composition, emerge once ic's determined whether had jusc been commissioned to write ished, along with its water, aeons ago? climate, geology, and evolutionary Mars, like Earth, has a magnetic field. the lyrics for the Marcian version of Although no one expects the Mars history than all previous miss ions co Currenc theory holds that a planet'S "America che Beauciful." "We know Observer, launched September 25 from Mars put together. -
Enantioselective, Convergent Synthesis of the Ineleganolide Core by a Tandem Annulation Cite This: Chem
Chemical Science View Article Online EDGE ARTICLE View Journal | View Issue Enantioselective, convergent synthesis of the ineleganolide core by a tandem annulation Cite this: Chem. Sci.,2017,8,507 cascade† Robert A. Craig, II, Jennifer L. Roizen, Russell C. Smith, Amanda C. Jones, Scott C. Virgil and Brian M. Stoltz* An enantioselective and diastereoselective approach toward the synthesis of the polycyclic norditerpenoid ineleganolide is disclosed. A palladium-catalyzed enantioselective allylic alkylation is employed to stereoselectively construct the requisite chiral tertiary ether and facilitate the synthesis of a 1,3-cis- cyclopentenediol building block. Careful substrate design enabled the convergent assembly of the ineleganolide [6,7,5,5]-tetracyclic scaffold by a diastereoselective cyclopropanation–Cope rearrangement cascade under unusually mild conditions. Computational evaluation of ground state energies of late-stage synthetic intermediates was used to guide synthetic development and aid in the Creative Commons Attribution 3.0 Unported Licence. investigation of the conformational rigidity of these highly constrained and compact polycyclic structures. This work represents the first successful synthesis of the core structure of any member of the furanobutenolide-derived polycyclic norcembranoid diterpene family of natural products. Advanced Received 28th July 2016 synthetic manipulations generated a series of natural product-like compounds that were shown to Accepted 15th August 2016 possess selective secretory antagonism of either interleukin-5 or interleukin-17. This bioactivity stands in DOI: 10.1039/c6sc03347d contrast to the known antileukemic activity of ineleganolide and suggests the norcembranoid natural www.rsc.org/chemicalscience product core may serve as a useful scaffold for the development of diverse therapeutics. This article is licensed under a Introduction this rigid polycyclic scaffold is decorated with a network of nine stereogenic centers, eight of which are contiguous.