Inhalation Injury in the Burned Patient
HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Ann Plast Manuscript Author Surg. Author Manuscript Author manuscript; available in PMC 2019 March 01. Published in final edited form as: Ann Plast Surg. 2018 March ; 80(3 Suppl 2): S98–S105. doi:10.1097/SAP.0000000000001377. Inhalation Injury in the Burned Patient Guillermo Foncerrada, M.D.1,2, Derek M. Culnan, M.D.3, Karel D. Capek, M.D.1,2, Sagrario González-Trejo, M.D.1,2, Janos Cambiaso-Daniel, M.D.1,2, Lee C. Woodson, M.D., Ph.D.2,4, David N. Herndon, M.D., F.A.C.S., M.C.C.M., F.R.C.S1,2, Celeste C. Finnerty, Ph.D.1,2, and Jong O. Lee, M.D.1,2 1Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA 2Shriners Hospitals for Children - Galveston, Galveston, Texas, USA 3JMS Burn and Reconstructive Center at Merit Health Central, Jackson, MS, USA 4Department of Anesthesiology, University of Texas Medical Branch Galveston, Texas, USA Abstract Inhalation injury causes a heterogeneous cascade of insults that increase morbidity and mortality among the burn population. Despite major advancements in burn care over the last several decades, there remains a significant burden of disease attributable to inhalation injury. For this reason effort has been devoted to find new therapeutic approaches to improve outcomes for patients who sustain inhalation injuries. The three major injury classes are: supraglottic, subglottic, and systemic. Treatment options between these three subtypes differ based on the pathophysiologic changes that each one elicits. Currently, no consensus exists for diagnosis or grading of the injury and there are large variations in treatment worldwide, ranging from observation and conservative management to advanced therapies with nebulization of different pharmacologic agents.
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